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chronic rhinosinusitis and asthma

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https://www.readbyqxmd.com/read/28804130/innate-lymphoid-cells-major-players-in-inflammatory-diseases
#1
REVIEW
Mikaël Ebbo, Adeline Crinier, Frédéric Vély, Eric Vivier
Recent years have seen a marked increase in our understanding of innate lymphoid cells (ILCs). ILCs can be classified into different groups based on their similarity to T cell subsets in terms of their expression of key transcription factors and cytokine production. Various immunological functions of ILCs have been described, and increasing numbers of studies have implicated these cells in inflammatory disorders. Here, we detail the roles of ILCs in inflammatory diseases; we cover type 2 inflammatory diseases (such as asthma, chronic rhinosinusitis and atopic dermatitis), as well as inflammatory bowel diseases, psoriasis and other systemic or organ-specific inflammatory and autoimmune diseases...
August 14, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28803775/pulmonary-function-in-patients-with-eosinophilic-chronic-rhinosinusitis
#2
Kensuke Uraguchi, Shin Kariya, Seiichiro Makihara, Mitsuhiro Okano, Takenori Haruna, Aiko Oka, Rumi Fujiwara, Yohei Noda, Kazunori Nishizaki
OBJECTIVE: There is a close relationship between upper and lower respiratory tract diseases. Chronic rhinosinusitis patients frequently have lung diseases including asthma and chronic obstructive pulmonary disease. Eosinophilic chronic rhinosinusitis is considered a refractory and intractable subtype of chronic rhinosinusitis. However, there has been no report on pulmonary function in patients with eosinophilic chronic rhinosinusitis. The purpose of this study is to examine the pulmonary function in eosinophilic chronic rhinosinusitis patients and non-eosinophilic chronic rhinosinusitis patients, and evaluate clinical factors associated with the pulmonary function of these patients...
August 10, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28783682/myosin-light-chains-9-and-12-are-functional-ligands-for-cd69-that-regulate-airway-inflammation
#3
Koji Hayashizaki, Motoko Y Kimura, Koji Tokoyoda, Hiroyuki Hosokawa, Kenta Shinoda, Kiyoshi Hirahara, Tomomi Ichikawa, Atsushi Onodera, Asami Hanazawa, Chiaki Iwamura, Jungo Kakuta, Kenzo Muramoto, Shinichiro Motohashi, Damon J Tumes, Tomohisa Iinuma, Heizaburo Yamamoto, Yuzuru Ikehara, Yoshitaka Okamoto, Toshinori Nakayama
Recent decades have witnessed a rapid worldwide increase in chronic inflammatory disorders such as asthma. CD4(+) T helper 2 cells play critical roles in the pathogenesis of allergic airway inflammation, and CD69 expression on activated CD4 T cells is required to induce allergic inflammation in tissues. However, how CD69 mechanistically controls allergic inflammation remains poorly defined. In lymphoid tissues, CD69 regulates cellular retention through inhibition of S1P1 expression and requires no specific ligands to function...
September 16, 2016: Science Immunology
https://www.readbyqxmd.com/read/28774699/pulmonary-and-sinus-fungal-diseases-in-non-immunocompromised-patients
#4
REVIEW
David W Denning, Arunaloke Chakrabarti
The human respiratory tract is exposed daily to airborne fungi, fungal enzymes, and secondary metabolites. The endemic fungi Histoplasma capsulatum, Coccidioides spp, Blastomyces dermatitidis, and Paracoccidioides brasiliensis, and occasionally Aspergillus fumigatus, are primary pulmonary pathogens of otherwise healthy people. Such infections resolve in most people, and only a few infections lead to disease. However, many fungi are directly allergenic by colonising the respiratory tract or indirectly through contact with cell wall constituents and proteases, causing or exacerbating allergic disease...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28743424/blood-eosinophil-to-basophil-ratio-in-patients-with-sinonasal-polyps-does-it-have-a-clinical-role
#5
Giuseppe Brescia, Umberto Barion, Claudia Zanotti, Francesco Cinetto, Luciano Giacomelli, Alessandro Martini, Gino Marioni
BACKGROUND: In a recent preliminary study, eosinophil and basophil counts were calculated in chronic rhinosinusitis with nasal polyps (CRSwNP) using conventional histologic and immunohistochemical methods. The tissue eosinophil-to-basophil ratio differed in the CRSwNP endotypes considered. OBJECTIVE: To compare the blood eosinophil-to-basophil ratio (bEBR) in a large series of patients with CRSwNP with that in a control group of consecutive rhinological patients with no evidence of nasal, paranasal, or systemic inflammatory disorders...
July 22, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28695715/patient-reported-signs-of-dampness-at-home-may-be-a-risk-factor-for-chronic-rhinosinusitis-a-cross-sectional-study
#6
Caroline Ahlroth Pind, María Gunnbjörnsdottír, Anders Bjerg, Bengt Järvholm, Bo Lundbäck, Andrei Malinovschi, Roelinde Middelveld, Johan Nilsson Sommar, Dan Norbäck, Christer Janson
BACKGROUND: An association between dampness at home and respiratory conditions has been convincingly demonstrated in children. Fewer studies have been performed in adults and data are lacking for chronic rhinosinusitis (CRS). With a prevalence of 10.9% in Europe, CRS imposes a significant burden on quality of life, as well as economy. OBJECTIVE: Our aim was to study CRS and other respiratory conditions in relation to dampness at home in a representative sample of adults...
July 11, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28693067/-chinese-expert-consensus-for-non-antiinfective-effects-and-clinical-use-of-macrolides
#7
J T Lin, Y M Zhang, X Zhou, C Z Wang, M Huang, C T Liu, C G Wu, H Y Wan, W C Yu, Y R Dai
Important/potential value of macrolides has been proved in the management of chronic respiratory diseases by increasing basic and clinical trials.Through three face-to-face discussions, 10 experts examined important data and drafted this consensus related to macrolides: (1) mechanism of non-antiinfective effects; (2) clinical use in chronic respiratory diseases; (3) cautions of long-term use.The mechanism out of non-antiinfective effects includes anti-inflammatory effect, modifying airway secretion, immune-regulation related to antibacterial effect, corticoid saving effect and anti-viral effect...
July 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28665518/increased-expression-of-tipe2-in-alternatively-activated-macrophages-is-associated-with-eosinophilic-inflammation-and-disease-severity-in-chronic-rhinosinusitis-with-nasal-polyps
#8
Yin Yao, Zhi-Chao Wang, Jin-Xin Liu, Jin Ma, Cai-Ling Chen, Yi-Ke Deng, Bo Liao, Nan Wang, Heng Wang, Qin Ning, Zheng Liu
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disorder characterized by exaggerated local immune responses. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is a novel protein with potential immune modulating function. The expression and function of TIPE2 in human airway diseases are unclear. METHODS: The expression of TIPE2 in sinonasal mucosal samples was assessed by means of quantitative reverse transcript-polymerse chain reaction, immunohistochemistry, and Western blotting...
June 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28648317/minimal-clinically-important-differences-mcids-of-the-thai-version-of-the-leicester-cough-questionnaire-for-subacute-and-chronic-cough
#9
Prapaporn Pornsuriyasak, Poungrat Thungtitigul, Theerasuk Kawamatawong, Surinder S Birring, Tipaporn Pongmesa
OBJECTIVES: To investigate the minimal clinically important differences (MCIDs) of the Thai version of the Leicester Cough Questionnaire (LCQ-T) in patients with subacute and chronic cough. METHODS: Patients with cough for 3 or more weeks were recruited from outpatient clinics. They self-completed the LCQ-T at an initial evaluation and repeated the LCQ-T with a Global Rating of Change scale at follow-up. For the anchor-based method, the MCID was defined as a change in the LCQ scores that corresponded to the smallest improvement in Global Rating of Change score (+2 to +3)...
May 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/28647751/chronic-rhinosinusitis-severity-is-associated-with-need-for-asthma-related-systemic-corticosteroids
#10
K M Phillips, L P Hoehle, R W Bergmark, A P Campbell, D S Caradonna, S T Gray, A R Sedaghat
BACKGROUND: Chronic rhinosinusitis (CRS) is highly prevalent in patients with asthma. However, no study has evaluated the effect of CRS severity on asthma-related oral corticosteroid use - a marker of poor asthma control and prognosis. We therefore sought to evaluate the association between CRS severity and asthma-related oral corticosteroid use. METHODOLOGY: Prospective cross-sectional study of 110 adult asthmatic CRS patients. CRS severity was measured using the 22-item Sinonasal Outcomes Test (SNOT-22) and Lund-Kennedy endoscopy score...
June 25, 2017: Rhinology
https://www.readbyqxmd.com/read/28572918/multi-morbidities-of-allergic-rhinitis-in-adults-european-academy-of-allergy-and-clinical-immunology-task-force-report
#11
REVIEW
C Cingi, P Gevaert, R Mösges, C Rondon, V Hox, M Rudenko, N B Muluk, G Scadding, F Manole, C Hupin, W J Fokkens, C Akdis, C Bachert, P Demoly, J Mullol, A Muraro, N Papadopoulos, R Pawankar, P Rombaux, E Toskala, L Kalogjera, E Prokopakis, P W Hellings, J Bousquet
This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28560517/a-contemporary-analysis-of-clinical-and-demographic-factors-of-chronic-rhinosinusitis-patients-and-their-association-with-disease-severity
#12
L P Hoehle, K M Phillips, D S Caradonna, S T Gray, A R Sedaghat
BACKGROUND: Chronic rhinosinusitis (CRS) is highly prevalent, significantly decreases quality of life and leads to tremendous health care costs every year. No recent study has characterised the prevalence of potentially CRS-modifying patient characteristics and simultaneously shown their impact on CRS severity. AIMS: We sought to determine the prevalence of potential clinical and demographic CRS-modifying characteristics and their associations with CRS symptom severity in a large contemporary cohort of CRS patients...
May 30, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28554933/an-investigation-on-the-use-of-snus-and-its-association-with-respiratory-and-sleep-related-symptoms-a-cross-sectional-population-study
#13
Arna Ýr Gudnadóttir, Inga Sif Ólafsdóttir, Roelinde Middelveld, Linda Ekerljung, Bertil Forsberg, Karl Franklin, Eva Lindberg, Christer Janson
INTRODUCTION: Studies of the health effects of moist oral tobacco, snus, have produced inconsistent results. The main objective of this study is to examine the health effects of snus use on asthma, respiratory symptoms and sleep-related problems, a field that has not been investigated before. METHODS AND MATERIAL: This cross-sectional study was based on a postal questionnaire completed by 26 697 (59.3%) participants aged 16 to 75 years and living in Sweden. The questionnaire included questions on tobacco use, asthma, respiratory symptoms and sleeping problems...
May 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28552275/delayed-type-of-allergic-skin-reaction-to-candida-albicans-in-eosinophilic-rhinosinusitis-cases
#14
Nozomu Wakayama, Shoji Matsune, Kimihiro Okubo
OBJECTIVE: Eosinophilic chronic rhinosinusitis (ECRS) is frequently complicated by asthma, and recognized as refractory and persistent rhinosinusitis. However, the detailed pathophysiology of ECRS has not been elucidated yet. In this study, we investigated the association between recurrent ECRS and intradermal testing to multi-antigens including Candida albicans. METHODS: The subjects were 49 cases of bilateral chronic rhinosinusitis including 24 ECRS cases. They underwent endoscopic sinus surgery and submitted to pathological examination...
May 25, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28532656/the-il-33-st2-axis-is-crucial-in-type-2-airway-responses-induced-by-the-staphylococcus-aureus-protease-spld
#15
Andrea R Teufelberger, Maria Nordengrün, Harald Braun, Tania Maes, Katrien De Grove, Gabriele Holtappels, Clara O'Brien, Sharen Provoost, Hamida Hammad, Amanda Gonçalves, Rudi Beyaert, Wim Declercq, Peter Vandenabeele, Dmitri V Krysko, Barbara M Bröker, Claus Bachert, Olga Krysko
BACKGROUND: Chronic airway inflammatory diseases such as chronic rhinosinusitis with nasal polyps and asthma showed increased nasal Staphylococcus aureus (S. aureus) colonization. Serine protease like protein D (SplD) and other closely related proteases secreted by S. aureus have recently been identified as inducers of allergic asthma in humans and mice but their mechanism of action is largely unknown. OBJECTIVE: We investigated the role of recombinant SplD in driving Th2-biased responses and IgE formation in a murine model of allergic asthma...
May 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28526278/biotherapeutics-in-chronic-rhinosinusitis-with-and-without-nasal-polyps
#16
Claus Bachert, Philippe Gevaert, Peter Hellings
In western countries, 85% of chronic rhinosinusitis with nasal polyp disease reveals a type 2 inflammatory pattern with expression of IL-4, -5, and -13 as well as increased concentrations of IgE, whereas chronic rhinosinusitis without nasal polyps merely expresses these biomarkers. The degree of type 2 inflammation furthermore is associated with disease severity, asthma comorbidity, and recurrence of disease after surgery. Therefore, these biomarkers also form the targets for innovative therapeutic approaches such as monoclonal antibodies directed against IgE, IL-5, and IL-4 receptor alpha, blocking the activity of IL-4 and -13...
May 16, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28521083/inflammatory-infiltrate-and-mucosal-remodeling-in-chronic-rhinosinusitis-with-and-without-polyps-structured-histopathologic-analysis
#17
Hannah N Kuhar, Bobby A Tajudeen, Mahboobeh Mahdavinia, Paolo Gattuso, Ritu Ghai, Pete S Batra
BACKGROUND: Chronic rhinosinusitis (CRS) is commonly classified into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Structured histopathologic reporting has the potential to identify salient histologic markers to differentiate subtypes and provide insights into pathophysiologic mechanisms in CRS. METHODS: A structured histopathology report of 13 variables was prospectively employed to analyze ethmoid sinus tissue removed during endoscopic sinus surgery for 99 patients, including 43 CRSsNP and 56 CRSwNP...
July 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28513250/combined-measurements-of-fractional-exhaled-nitric-oxide-and-nasal-nitric-oxide-levels-for-assessing-upper-airway-diseases-in-asthmatic-patients
#18
Takamitsu Asano, Masaya Takemura, Yoshihiro Kanemitsu, Makoto Yokota, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Hisatoshi Hijikata, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Atsushi Nakamura, Yumi Maki, Yoshihisa Nakamura, Motohiko Suzuki, Akio Niimi
BACKGROUND: Despite the close linkage between rhinitis, chronic rhinosinusitis (CRS) and asthma, relevant biomarkers of both upper and lower airway inflammation are rare. METHODS: Patients with asthma (without upper airway disease [UAD; n = 24], with rhinitis [n = 25], CRS [n = 24], and nasal polyps [n = 2]), isolated rhinitis (n = 13), isolated CRS (n = 13), and 10 healthy controls were prospectively recruited. Fractional exhaled nitric oxide (NO) levels at 50 mL/s (FeNO50), nasal NO levels, Lund-Macay-scores of sinus computed tomography and an asthma control questionnaire (ACQ) were evaluated...
May 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28497916/emerging-endotypes-of-chronic-rhinosinusitis-and-its-application-to-precision-medicine
#19
REVIEW
Dae Woo Kim, Seong H Cho
Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with various underlying pathophysiologic mechanisms which translate to endotypes, in contrast to clinical phenotypes or histological subtypes. Defining endotypes can help clinicians predict disease prognosis, select subjects suitable for a specific therapy, and assess risks for comorbid conditions, including asthma. Therefore, with recent advancement of biologicals in CRS clinical trials, endotyping can be a breakthrough in treating recalcitrant CRS...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28482010/study-toward-resolving-the-controversy-over-the-definition-of-allergic-fungal-rhinosinusitis
#20
Aleksandra Barac, Goran Stevanovic, Marina Pekmezovic, Zoran Rakocevic, Rajica Stosovic, Boban Erovic, Vesna Tomic Spiric
Dysbiosis of the microbiome on the airway mucosa leads to the development of chronic inflammatory and allergic disorders. The aim of this study was to consider the potential diagnostic criteria for allergic fungal rhinosinusitis (AFRS) and nonallergic fungal rhinosinusitis (FRS), and the role of fungal presence in an environment for the development of AFRS. In this study, 136 patients were divided into two groups: patients with positive specific immunoglobulin E (sIgE) and fungal finding (AFRS group), and patients with negative sIgE and positive fungal finding (FRS group)...
May 6, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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