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https://www.readbyqxmd.com/read/28651011/indications-of-airway-stenting-for-severe-central-airway-obstruction-due-to-advanced-cancer
#1
Hiroaki Nagano, Tomoo Kishaba, Yuichirou Nei, Shin Yamashiro, Hiroaki Takara
BACKGROUND: Management of severe central airway obstruction due to advanced cancer is a medical and technical challenge. The impact of airway stenting on the clinical outcome of such patients is unclear. METHOD: This single-center, retrospective study evaluated 21 patients who underwent airway stenting for advanced cancer. We examined predictors of the post-stenting mortality, including age, serum albumin, tracheal diameter, smoking, opioid use, respiratory failure, and performance status (PS)...
2017: PloS One
https://www.readbyqxmd.com/read/28650070/the-human-ventilatory-response-to-stress-rate-or-depth
#2
Michael J Tipton, Abbi Harper, Julian F R Paton, Joseph T Costello
Many stressors cause an increase in ventilation in humans. This is predominantly reported as an increase in minute ventilation (V̇E ). But, the same V̇E can be achieved by a wide variety of changes in the depth (tidal volume, VT ) and number of breaths (respiratory frequency, ƒR). This review investigates the impact of stressors including: cold, heat, hypoxia, pain and panic on the contributions of ƒR and VT to V̇E to see if they differ with different stressors. Where possible we also consider the potential mechanisms that underpin the responses identified, and propose mechanisms by which differences in ƒR and VT are mediated...
June 26, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28649803/first-detection-of-porcine-circovirus-type-3-on-commercial-pig-farms-in-poland
#3
T Stadejek, A Woźniak, D Miłek, K Biernacka
Porcine circovirus type 3 (PCV3) is a novel circovirus species recently discovered in USA and China in cases of porcine dermatitis and nephropathy syndrome, reproductive failure, respiratory disease and multisystemic inflammation. This study reports on the first identification of PCV3 in Europe, in serum from pigs from Polish farms. A total of 1,050 serum samples were collected between 2014 and 2017 from sows and 3-20 weeks old pigs from 14 commercial farms representing different regions of Poland, different size and health status...
June 26, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28649488/hemoptysis-in-a-previously-healthy-elderly-patient-with-an-unrecognized-tracheal-bronchus-a-case-report
#4
Moayad Ismail, Paunel Vukasinov, Hung-I Liao, Parvez Mir
A 83-year-old healthy female with no past medical history presented with persistent hemoptysis and respiratory failure. She was found to have a tracheal bronchus on bronchoscopy. Patient underwent pulmonary lavage and sterile irrigation. Patient was stable, but developed excessive hemoptysis which prompted a repeat, emergent, bronchoscopy was performed to advance the ET tube to isolate the left lung from the bleeding right lung. Despite the effort taken, the patient became pulseless from the hypoxia caused by blood spillover into the entire tracheobronchial field...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28648543/seasonal-influenza-vaccine-effectiveness-against-laboratory-confirmed-influenza-hospitalizations-latin-america-2013
#5
Nathalie El Omeiri, Eduardo Azziz-Baumgartner, Mark G Thompson, Wilfrido Clará, Mauricio Cerpa, Rakhee Palekar, Sara Mirza, Alba María Ropero-Álvarez
BACKGROUND: Despite widespread utilization of influenza vaccines, effectiveness (VE) has not been routinely measured in Latin America. METHODS: We used a case test-negative control design to estimate trivalent inactivated influenza VE against laboratory-confirmed influenza among hospitalized children aged 6months-5years and adults aged ≥60years which are age-groups targeted for vaccination. We sought persons with severe acute respiratory infections (SARI), hospitalized at 71 sentinel hospitals in Argentina, Brazil, Chile, Colombia, Costa Rica, El Salvador, Honduras, Panama, and Paraguay during January-December 2013...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28648227/the-management-privacy-and-medico-legal-issues-of-electronic-cpap-data-in-australia-and-new-zealand-electronic-cpap-data-management-in-australia-and-new-zealand
#6
John Swieca, Garun S Hamilton, Hailey Meaklim
STUDY OBJECTIVE: Continuous Positive Airway Pressure (CPAP) is considered to be the gold standard treatment for obstructive sleep apnoea (OSA). CPAP monitoring systems allow tracking of patient CPAP adherence and treatment efficacy, by measuring residual sleep-disordered breathing, hours of CPAP use, and mask leak etc. The American Thoracic Society (ATS) published a position paper in 2013 highlighting issues of interpreting CPAP data such as a lack of consistency between CPAP manufacturers data algorithms, legal implications of CPAP data and implications for CPAP adherence...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28647513/respiratory-syncytial-virus-bronchiolitis-weather-conditions-and-air-pollution-in-an-italian-urban-area-an-observational-study
#7
Raffaella Nenna, Melania Evangelisti, Antonella Frassanito, Carolina Scagnolari, Alessandra Pierangeli, Guido Antonelli, Ambra Nicolai, Serena Arima, Corrado Moretti, Paola Papoff, Maria Pia Villa, Fabio Midulla
BACKGROUND: In this study we sought to evaluate the association between viral bronchiolitis, weather conditions, and air pollution in an urban area in Italy. METHODS: We included infants hospitalized for acute bronchiolitis from 2004 to 2014. All infants underwent a nasal washing for virus detection. A regional agency network collected meteorological data (mean temperature, relative humidity and wind velocity) and the following air pollutants: sulfur dioxide, nitrogen oxide, carbon monoxide, ozone, benzene and suspended particulate matter measuring less than 10µm (PM10) and less than 2...
June 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/28647362/farnesoid-x-receptor-agonist-gw4064-ameliorates-lipopolysaccharide-induced-ileocolitis-through-tlr4-myd88-pathway-related-mitochondrial-dysfunction-in-mice
#8
Hsuan-Miao Liu, Jyh-Fe Liao, Tzung-Yan Lee
Inflammatory bowel disease (IBD) is a complex and relapsing inflammatory condition of the gastro intestinal tract characterized by diarrhea and abdominal pain. Farnesoid X receptor (FXR) plays an important role in enteroprotection and mucosal injury by regulating inflammatory responses and barrier function in the intestinal tract. Here we show the mechanisms of FXR agonist, GW4064, inhibits mucosal injury in ileum caused by lipopolysaccharides (LPS). Ileum injury was induced by intraperitoneal injection of LPS in Wild-type (WT) and FXR knockout (KO) mice...
June 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28646582/comprehensive-mathematical-model-of-oxidative-phosphorylation-valid-for-physiological-up-to-pathological-conditions
#9
Margit Heiske, Thierry Letellier, Edda Klipp
We developed a mathematical model of oxidative phosphorylation (OXPHOS) that allows for a precise description of mitochondrial function with respect to the respiratory flux and the ATP production. The model reproduced flux-force relationships under various experimental conditions (state 3 and 4, uncoupling, shortage of respiratory substrate) as well as time courses, exhibiting correct P/O ratios. The model was able to reproduce experimental threshold curves for perturbations of the respiratory chain complexes, the F1 F0 -ATP synthase, the ADP/ATP carrier, the phosphate/OH carrier, and the proton leak...
June 24, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28646113/aerosolization-of-mycotoxins-after-growth-of-toxinogenic-fungi-on-wallpaper
#10
Brankica Aleksic, Marjorie Draghi, Sebastien Ritoux, Sylviane Bailly, Marlène Lacroix, Isabelle P Oswald, Jean-Denis Bailly, Enric Robine
Many fungi can develop on building material in indoor environments if moisture is high enough. Among species that are frequently observed, some are known to be potent mycotoxin producers. This presence of toxinogenic fungi in indoor environments raises the question of the possible exposure of occupants to these toxic compounds by inhalation after aerosolization.This study investigated the mycotoxin production by Penicillium brevicompactum, Aspergillus versicolor and Stachybotrys chartarum during their growth on wallpaper and the possible subsequent aerosolization of produced mycotoxins from contaminated substrates...
June 23, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28644389/chronic-respiratory-infection-in-patients-with-chronic-obstructive-pulmonary-disease-what-is-the-role-of-antibiotics
#11
REVIEW
Marc Miravitlles, Antonio Anzueto
Chronic infections are associated with exacerbation in patients with chronic obstructive pulmonary disease (COPD). The major objective of the management of these patients is the prevention and effective treatment of exacerbations. Patients that have increased sputum production, associated with purulence and worsening shortness of breath, are the ones that will benefit from antibiotic therapy. It is important to give the appropriate antibiotic therapy to prevent treatment failure, relapse, and the emergence of resistant pathogens...
June 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28644175/guillain-barr%C3%A3-syndrome-after-elective-spinal-surgery
#12
Eric Yensen Chen, Corinne Stratton, Brian Mercer, Anna Hohler, Tony Y Tannoury, Chadi Tannoury
Guillain-Barré syndrome is a rare autoimmune condition characterized by ascending motor weakness of the extremities that can ascend to the diaphragm, causing substantial morbidity and mortality. This case report describes a 57-year-old man who exhibited characteristics of Guillain-Barré syndrome 9 days after undergoing lumbar fusion at L3-S1. The diagnosis was based on the patient's ascending motor weakness and areflexia and was confirmed with electromyography. The patient progressed to respiratory failure, requiring mechanical ventilation...
June 21, 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28643675/-stop-bang-a-useful-and-easy-tool-for-the-screening-of-obstructive-sleep-apnea
#13
Matías Baldini, María Nélida Chiapella, María Alejandra Fernández, Sergio Guardia
The STO-BANG questionnaire, S standing for snore, T tired, O observed apneas, P pressure (arterial hypertension), B BMI (body mass index > 35 kg/ m2), A age (> 50 years old), N neck circumference (> 40 cm), G gender (male); is a simple tool that enables the detection of patients with obstructive sleep apnea syndrome (OSA). If the patient adds 3 or more points, it is considered to have a high probability of having this disease. Our goal was to evaluate the capacity of the STOP-BANG questionnaire and to compare it with the ability of a sleep trained pulmonologist in determining the probability of OSA...
2017: Medicina
https://www.readbyqxmd.com/read/28643320/revised-protocol-of-extracorporeal-membrane-oxygenation-ecmo-therapy-in-severe-ards-recommendations-of-the-veno-venous-ecmo-expert-panel-appointed-in-february-2016-by-the-national-consultant-on-anesthesiology-and-intensive-care
#14
Romuald Lango, Zbigniew Szkulmowski, Dariusz Maciejewski, Andrzej Sosnowski, Krzysztof Kusza
Extracorporeal Membrane Oxygenation (ECMO) has become well established technique of the treatment of severe acute respiratory failure (Veno-Venous ECMO) or circulatory failure (Veno-Arterial ECMO) which enables effective blood oxygenation and carbon dioxide removal for several weeks. Veno-Venous ECMO (V-V ECMO ) is a lifesaving treatment of patients in whom severe ARDS makes artificial lung ventilation unlikely to provide satisfactory blood oxygenation for preventing further vital organs damage and progression to death...
2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28643188/impact-of-appropriateness-of-empiric-therapy-on-outcomes-in-community-onset-bacteremia-by-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-and-klebisella-pneumoniae-definitively-treated-with-carbapenems
#15
E-J Joo, D A Park, N R Lee, S-Y Moon, J-K Choi, J-H Ko, K R Peck
Despite a significant increase of bloodstream infection caused by extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae in the community-setting, information regarding clinical outcomes of inappropriate empiric therapy (IAT) in patients with those infections is limited. A multicenter-retrospective cohort study was conducted in four hospitals. A total of 249 adults were identified to have community-onset bacteremia caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae, and definitively treated with carbapenems...
June 23, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28642454/inclusion-body-myositis-a-case-presenting-with-respiratory-failure-and-autopsy-findings-leading-to-the-hypothesis-of-a-paraneoplastic-cause
#16
Christopher Dardis, Ariel Antezana, Kurenai Tanji, Paul J Maccabee
BACKGROUND Sporadic inclusion body myositis (IBM) is the most common acquired myopathy seen in adults aged over 50 years, with a prevalence estimated at between 1 and 70 per million. Weakness of the diaphragm with loss of vital capacity is almost universal in IBM. This is almost always asymptomatic. When respiratory complications occur, they are most often due to aspiration. Respiratory failure due to diaphragmatic weakness is exceptionally rare, particularly as the presenting symptom of the disease. It is not currently considered to be a paraneoplastic syndrome...
June 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28642307/urban-green-and-grey-space-in-relation-to-respiratory-health-in-children
#17
Christina Tischer, Mireia Gascon, Ana Fernández-Somoano, Adonina Tardón, Aitana Lertxundi Materola, Jesus Ibarluzea, Amparo Ferrero, Marisa Estarlich, Marta Cirach, Martine Vrijheid, Elaine Fuertes, Albert Dalmau-Bueno, Mark J Nieuwenhuijsen, Josep M Antó, Jordi Sunyer, Payam Dadvand
We assessed the effect of three different indices of urban built environment on allergic and respiratory conditions.This study involved 2472 children participating in the ongoing INMA birth cohort located in two bio-geographic regions (Euro-Siberian and Mediterranean) in Spain. Residential surrounding built environment was characterised as 1) residential surrounding greenness based on satellite-derived normalised difference vegetation index (NDVI), 2) residential proximity to green spaces and 3) residential surrounding greyness based on urban land use patterns...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28642067/caloric-restriction-protects-livers-from-ischemia-reperfusion-damage-by-preventing-ca-2-induced-mitochondrial-permeability-transition
#18
Sergio L Menezes-Filho, Ignacio Amigo, Fernanda M Prado, Natalie C Ferreira, Marcia K Koike, Isabella F D Pinto, Sayuri Miyamoto, Edna F S Montero, Marisa H G Medeiros, Alicia J Kowaltowski
Caloric restriction (CR) promotes lifespan extension and protects against many pathological conditions, including ischemia/reperfusion injury to the brain, heart and kidney. In the liver, ischemia/reperfusion damage is related to excessive mitochondrial Ca(2+) accumulation, leading to the mitochondrial permeability transition. Indeed, liver mitochondria isolated from animals maintained on CR for 4 months were protected against permeability transition and capable of taking up Ca(2+) at faster rates and in larger quantities...
June 19, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28641894/carbon-assimilation-and-losses-during-an-ocean-acidification-mesocosm-experiment-with-special-reference-to-algal-blooms
#19
Nana Liu, Shanying Tong, Xiangqi Yi, Yan Li, Zhenzhen Li, Hangbin Miao, Tifeng Wang, Futian Li, Dong Yan, Ruiping Huang, Yaping Wu, David A Hutchins, John Beardall, Minhan Dai, Kunshan Gao
A mesocosm experiment was conducted in Wuyuan Bay (Xiamen), China, to investigate the effects of elevated pCO2 on bloom formation by phytoplankton species previously studied in laboratory-based ocean acidification experiments, to determine if the indoor-grown species performed similarly in mesocosms under more realistic environmental conditions. We measured biomass, primary productivity and particulate organic carbon (POC) as well as particulate organic nitrogen (PON). Phaeodactylum tricornutum outcompeted Thalassiosira weissflogii and Emiliania huxleyi, comprising more than 99% of the final biomass...
May 27, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28641244/computerized-lung-sound-screening-for-pediatric-auscultation-in-noisy-field-environments
#20
Dimitra Emmanouilidou, Eric D McCollum, Daniel E Park, Mounya Elhilali
GOAL: Chest auscultations offer a non-invasive and low-cost tool for monitoring lung disease. However, they present many shortcomings including inter-listener variability, subjectivity, and vulnerability to noise and distortions. The current work proposes a computer-aided approach to process lung signals acquired in the field under adverse noisy conditions, by improving the signal quality and offering automated iden- tification of abnormal auscultations indicative of respiratory pathologies...
June 19, 2017: IEEE Transactions on Bio-medical Engineering
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