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https://www.readbyqxmd.com/read/28737430/nivolumab-for-the-treatment-of-bladder-cancer
#1
Oliver W Hakenberg
The checkpoint inhibitor nivolumab has recently demonstrated effectiveness against metatstatic urothelial carcinoma. Nivolumab is a fully human monoclonal antibody blocking PD-1 and thereby enhancing antitumour immune mechanisms. Areas covered: In this review, the authors describe the treatment of metastatic bladder cancer with nivolumab against the background of the standard treatment with cisplatin-based chemotherapy which can prolong overall survival from 3-6 months in untreated cases to over one year. Different combinations of cisplatin-based chemotherapy can further prolong survival by only a few months...
July 24, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28737424/facilitator-and-participant-use-of-facebook-in-a-community-based-intervention-for-parents-the-infant-extend-program
#2
Katherine L Downing, Karen J Campbell, Paige van der Pligt, Kylie D Hesketh
BACKGROUND: Social networking sites such as Facebook afford new opportunities for behavior-change interventions. Although often used as a recruitment tool, few studies have reported the use of Facebook as an intervention component to facilitate communication between researchers and participants. The aim of this study was to examine facilitator and participant use of a Facebook component of a community-based intervention for parents. METHODS: First-time parent groups participating in the intervention arm of the extended Infant Feeding, Activity and Nutrition Trial (InFANT Extend) Program were invited to join their own private Facebook group...
July 24, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28736847/reproductive-plasticity-and-landscape-heterogeneity-benefit-a-ground-nesting-bird-in-a-fire-prone-ecosystem
#3
J Matthew Carroll, Torre J Hovick, Craig A Davis, R Dwayne Elmore, Samuel D Fuhlendorf
Disturbance is critical for the conservation of rangeland ecosystems worldwide and many of these systems are fire dependent. Although it is well established that restoring fire as an ecological process can lead to increased biodiversity in grasslands and shrublands, the underlying mechanisms driving community patterns are poorly understood for fauna in fire-prone landscapes. Much of this uncertainty stems from the paucity of studies that examine the effects of fire at scales relevant to organism life histories...
July 24, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28736678/rapid-assessment-zika-virus-knowledge-among-clinical-specialists-in-singapore-a-cross-sectional-survey
#4
Chee F Yung, Clarence C Tam, Victor S Rajadurai, Jerry Ky Chan, Mabel Sf Low, Yong H Ng, Koh C Thoon, Lay K Tan
INTRODUCTION: We report the results of a rapid assessment of Zika virus awareness among key clinical specialties in Singapore. METHODS: Between June 6 and June 19, 2016 we conducted an online survey of doctors working in obstetrics and gynaecology, neonatology and paediatrics in Singapore. The survey included 15 multiple choice questions to measure respondents' knowledge of Zika virus in four domains covering clinical and public health. RESULTS: A total of 110 survey responses (15% response rate) were obtained, 82% of respondents worked in the public sector...
May 3, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28736573/a-rapid-and-efficient-in-vitro-regeneration-system-for-lettuce-lactuca-sativa-l
#5
Isabel Armas, Natalia Pogrebnyak, Ilya Raskin
BACKGROUND: Successful biotechnological improvement of crop plants requires a reliable and efficient in vitro regeneration system. Lettuce (Lactuca sativa L.), one the most important vegetable crops worldwide, is strongly genotype-dependent in terms of regeneration capacity, limiting the potential for biotechnological improvement of cultivars which show recalcitrance under currently available protocols. The effect of different nutrient sources, plant hormone combinations and activated charcoal supplementation on shoot induction efficiency was evaluated on the cultivar 'RSL NFR', which had previously shown poor regeneration efficiency...
2017: Plant Methods
https://www.readbyqxmd.com/read/28736541/hallucinations-in-healthy-older-adults-an-overview-of-the-literature-and-perspectives-for-future-research
#6
REVIEW
Johanna C Badcock, Hedwige Dehon, Frank Larøi
KEY POINTS ➢ Studies suggest a substantial minority of healthy older adults have hallucinatory experiences, in line with existing evidence on hallucinations in other age groups, though it is still unclear if hallucination prevalence increases or declines with age in older cohorts.➢ Stigma attached to both hallucinations and ageing leads to considerable under-reporting of these experiences in healthy older adults and may negatively bias how professionals, family members, and the public respond.➢ Why and when hallucinations in healthy older adults remit, persist, or progress to other clinical disorders remains poorly understood...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28735774/trends-in-hepatitis-c-antibody-prevalence-among-aboriginal-and-torres-strait-islander-people-attending-australian-needle-and-syringe-programs-1996-2015
#7
Simon Graham, Lisa Maher, Handan Wand, Michael Doyle, Jenny Iversen
BACKGROUND: Research indicates that hepatitis C antibody (anti-HCV) prevalence is higher among Australian Aboriginal and Torres Strait Islander (Aboriginal) than non-Aboriginal people who inject drugs (PWID). We examined trends in demographic and drug use characteristics and anti-HCV prevalence among Australian Needle and Syringe Program Survey (ANSPS) respondents by Aboriginal status from 1996 to 2015. METHODS: The ANSPS survey involved collecting demographic, behavioural data and a dried blood spot for anti-HCV testing...
July 20, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28735572/early-nutritional-intervention-can-improve-utilisation-of-vegetable-based-diets-in-diploid-and-triploid-atlantic-salmon-salmo-salar-l
#8
Michael Clarkson, Herve Migaud, Christoforos Metochis, Luisa M Vera, Daniel Leeming, Douglas R Tocher, John F Taylor
The present study investigated nutritional programming in Atlantic salmon to improve utilisation of a vegetable-based diet. At first exogenous feeding, fry were fed either a marine-based diet (Diet Mstimulus, 80% fishmeal (FM)/4% fish oil (FO)) or a vegetable-based diet (Diet Vstimulus, 10% FM/0% FO) for 3 weeks. Subsequently, all fish were then fed under the same conditions with a commercial, marine-based, diet for 15 weeks and thereafter challenged with a second V diet (Diet Vchallenge, 10% FM/0% FO) for 6 weeks...
July 24, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28734979/rumination-interacts-with-life-stress-to-predict-depressive-symptoms-an-ecological-momentary-assessment-study
#9
Samantha L Connolly, Lauren B Alloy
Rumination is a well-established vulnerability factor for depression that may exert deleterious effects both independently and in interaction with stress. The current study examined momentary ruminative self-focus (MRS) and stress-reactive rumination (SRR) as predictors of depressive symptoms utilizing a smartphone ecological momentary assessment (EMA) design. 121 undergraduates responded to four text message alerts per day for one week in which they indicated the occurrence of life stress, rumination, and depressed mood...
July 16, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28734773/epico-4-0-total-quality-in-the-management-of-invasive-candidiasis-in-critically-ill-patients-by-analysing-the-integrated-process
#10
Rafael Zaragoza, Ricard Ferrer, Pedro Llinares, Emilio Maseda, Alejandro Rodríguez, Santiago Grau, Guillermo Quindós
BACKGROUND: A high quality integrated process in the clinical setting of non-neutropenic critically ill patients at risk for invasive candidiasis is a necessary tool to improve the management of these patients. AIMS: To identify the key points on invasive candidiasis in order to develop a set of recommendations with a high level of consensus required for the creation of a total quality integrated process for the management of non-neutropenic critically ill patients at risk of invasive candidiasis...
July 19, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28734695/response-of-the-bacterial-community-in-an-on-farm-biopurification-system-to-which-diverse-pesticides-are-introduced-over-an-agricultural-season
#11
Peter N Holmsgaard, Simone Dealtry, Vincent Dunon, Holger Heuer, Lars H Hansen, Dirk Springael, Kornelia Smalla, Leise Riber, Søren J Sørensen
A biopurification system (BPS) is used on-farm to clean pesticide-contaminated wastewater. Due to high pesticide loads, a BPS represents a hot spot for the proliferation and selection as well as the genetic adaptation of discrete pesticide degrading microorganisms. However, while considerable knowledge exists on the biodegradation of specific pesticides in BPSs, the bacterial community composition of these systems has hardly been explored. In this work, the Shannon diversity, the richness and the composition of the bacterial community within an operational BPS receiving wastewater contaminated with various pesticides was, for the first time, elucidated over the course of an agricultural season, using DGGE profiling and pyrosequencing of 16S rRNA gene fragments amplified from total community DNA...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734545/engineered-hydrogels-in-cancer-therapy-and-diagnosis
#12
REVIEW
Mohammadmajid Sepantafar, Reihan Maheronnaghsh, Hossein Mohammadi, Fatemeh Radmanesh, Mohammad Mahdi Hasani-Sadrabadi, Marzieh Ebrahimi, Hossein Baharvand
Over the last decade, numerous investigations have attempted to clarify the intricacies of tumor development to propose effective approaches for cancer treatment. Thanks to the unique properties of hydrogels, researchers have made significant progress in tumor model reconstruction, tumor diagnosis, and associated therapies. Notably, hydrogel-based systems can be adjusted to respond to cancer-specific hallmarks and/or external stimuli. These well-known drug reservoirs can be used as smart carriers for multiple cargos, including both naked and nanoparticle-encapsulated chemotherapeutics, genes, and radioisotopes...
July 19, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28734128/the-experience-of-initiating-injection-drug-use-and-its-social-context-a-qualitative-systematic-review-and-thematic-synthesis
#13
REVIEW
Andy Guise, Danielle Horyniak, Jason Melo, Ryan McNeill, Dan Werb
BACKGROUND AND AIM: Understanding the experience of initiating injection drug use and its social contexts is crucial to inform efforts to prevent transitions into this mode of drug consumption and support harm reduction. We systematically reviewed and synthesized existing qualitative scientific literature to identify the socio-structural contexts for, and experiences of, the initiation of injection drug use. METHODS: We systematically searched six databases (Medline, Embase, PsychINFO, CINAHL, IBSS, and SSCI), along with a manual search, including of key journals and subject experts...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28733672/trainee-surgeons-affect-operative-time-but-not-outcome-in-minimally-invasive-total-hip-arthroplasty
#14
Markus Weber, Achim Benditz, Michael Woerner, Daniela Weber, Joachim Grifka, Tobias Renkawitz
Training of young surgeons in total hip arthroplasty (THA) is crucial, but might affect operative time and outcome especially in minimally invasive (MIS) THA. We asked whether the learning curve of orthopaedic residents trained on MIS THA has an impact on (1) operative time (2) complication rates and (3) early postoperative outcome. In a retrospective analysis of over 1000 MIS THAs from our institutional joint registry, operative time, complication rates, patient reported outcome measures (Western Ontario and McMaster Universities Arthritis Index [WOMAC] and Euro-Qol 5D-5L [EQ-5D]) within the first year and responder rates for positive outcome as defined by the Outcome Measures in Rheumatology and Osteoarthritis Research Society International consensus responder (OMERACT-OARSI) criteria were compared between trainee and senior surgeons...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733389/cytokinin-biosynthesis-promotes-cortical-cell-responses-during-nodule-development
#15
Dugald Elgin Reid, Marcin Nadzieja, Ondrej Novak, Anne Birgitte Heckmann, Niels Sandal, Jens Stougaard
Legume mutants have shown the requirement for receptor-mediated cytokinin signalling in symbiotic nodule organogenesis. While the receptors are central regulators, cytokinin is also accumulated during early phases of symbiotic interaction but the pathways involved have not yet been fully resolved. To identify the source, timing and effect of this accumulation, we followed transcript levels of the cytokinin biosynthetic pathway genes in a sliding developmental zone of Lotus japonicus roots. LjIpt2 and LjLog4 were identified as the major contributors to the first cytokinin burst...
July 21, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28733228/progressive-erosion-of-the-relaxin1-gene-in-bovids
#16
Loggan Malone, Juan C Opazo, Peter L Ryan, Federico G Hoffmann
The relaxin/insulin-like (RLN/INSL) gene family is a group of genes that encode peptide hormones involved in a variety of physiological functions related to reproduction. Previous studies have shown that relaxin plays a key role in widening of the pubic bone during labor and in gamete maturation. Because of these functions, studying the evolution of RLN1, the gene encoding for relaxin, is relevant in livestock species, most of which belong in the group Laurasiatheria, which includes cow, pig, horse, goat, and sheep in addition to bats, cetaceans and carnivores...
July 18, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28732752/effects-of-voice-therapy-a-comparison-between-individual-and-group-therapy
#17
Malin Abrahamsson, Moa Millgård, Christina Havstam, Lisa Tuomi
OBJECTIVE: The primary aim of this clinical evaluation project is to study the effect of voice therapy given in the speech-language pathology clinic, as individual and group therapy, as well as finding out some of the reasons for not attending the recommended therapy. METHOD: All patients visiting the speech-language department during the study period were asked to participate in a clinical evaluation project. The project included filling out the questionnaire Swedish Voice Handicap Index (VHI-11) twice: at their first visit at the clinic, and approximately 1 year later...
July 18, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28732490/positive-ageing-perceptions-among-migrant-turkish-and-native-dutch-older-people-a-matter-of-culture-or-resources
#18
Jane M Cramm, Anna P Nieboer
BACKGROUND: This study examined ethnic differences in ageing perceptions of migrant Turkish and native Dutch elders residing in Rotterdam, and explored whether such differences could be attributed to culture or resources (personal, physical, economic and/or social). METHODS: This study was based on combined data from two research projects focusing on the health and well-being of community-dwelling elderly people in Rotterdam. The first dataset contained data from 994 native Dutch elders aged 70-99 years...
July 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28732193/what-should-a-website-dedicated-to-the-postnatal-period-contain-a-delphi-survey-among-parents-and-professionals
#19
J Slomian, P Emonts, M Erpicum, L Vigneron, J Y Reginster, O Bruyère
OBJECTIVES: Mothers have a great need for information during the postnatal period. Trying to meet this need, mothers are increasingly turning to the Internet. Nevertheless, many women have stated that they often or always found that the information that they found on the Internet was incomplete or wrong. Many women therefore believe that health professionals should suggest reliable Internet websites for new mothers. The aim of this study was therefore to find a consensus on the content of a reliable and centralized website dedicated to mothers from the end of pregnancy to 1 year after childbirth...
July 6, 2017: Midwifery
https://www.readbyqxmd.com/read/28732057/structural-basis-of-zn-ii-induced-metal-detoxification-and-antibiotic-resistance-by-histidine-kinase-czcs-in-pseudomonas-aeruginosa
#20
Dan Wang, Weizhong Chen, Shanqing Huang, Yafeng He, Xichun Liu, Qingyuan Hu, Tianbiao Wei, Hong Shang, Jianhua Gan, Hao Chen
Pseudomonas aeruginosa (P. aeruginosa) is a major opportunistic human pathogen, causing serious nosocomial infections among immunocompromised patients by multi-determinant virulence and high antibiotic resistance. The CzcR-CzcS signal transduction system in P. aeruginosa is primarily involved in metal detoxification and antibiotic resistance through co-regulating cross-resistance between Zn(II) and carbapenem antibiotics. Although the intracellular regulatory pathway is well-established, the mechanism by which extracellular sensor domain of histidine kinase (HK) CzcS responds to Zn(II) stimulus to trigger downstream signal transduction remains unclear...
July 21, 2017: PLoS Pathogens
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