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https://www.readbyqxmd.com/read/28944980/failure-mode-and-effects-analysis-a-community-practice-perspective
#1
Bradley W Schuller, Angi Burns, Elizabeth A Ceilley, Alan King, Joan LeTourneau, Alexander Markovic, Lynda Sterkel, Brigid Taplin, Jennifer Wanner, Jeffrey M Albert
PURPOSE: To report our early experiences with failure mode and effects analysis (FMEA) in a community practice setting. METHODS: The FMEA facilitator received extensive training at the AAPM Summer School. Early efforts focused on department education and emphasized the need for process evaluation in the context of high profile radiation therapy accidents. A multidisciplinary team was assembled with representation from each of the major department disciplines. Stereotactic radiosurgery (SRS) was identified as the most appropriate treatment technique for the first FMEA evaluation, as it is largely self-contained and has the potential to produce high impact failure modes...
September 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28944771/the-spectrum-of-t-cell-metabolism-in-health-and-disease
#2
REVIEW
Glenn R Bantug, Lorenzo Galluzzi, Guido Kroemer, Christoph Hess
In healthy individuals, metabolically quiescent T cells survey lymph nodes and peripheral tissues in search of cognate antigens. During infection, T cells that encounter cognate antigens are activated and - in a context-specific manner - proliferate and/or differentiate to become effector T cells. This process is accompanied by important changes in cellular metabolism (known as metabolic reprogramming). The magnitude and spectrum of metabolic reprogramming as it occurs in T cells in the context of acute infection ensure host survival...
September 25, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28944726/paying-for-cures-how-can-we-afford-it-managed-care-pharmacy-stakeholder-perceptions-of-policy-options-to-address-affordability-of-prescription-drugs
#3
Kai Yeung, Kangho Suh, Anirban Basu, Louis P Garrison, Aasthaa Bansal, Josh J Carlson
BACKGROUND: High-priced medications with curative potential, such as the newer hepatitis C therapies, have contributed to the recent growth in pharmaceutical expenditure. Despite the obvious benefits, health care decision makers are just beginning to grapple with questions of how to value and pay for curative therapies that may feature large upfront cost, followed by health benefits that are reaped over a patient's lifespan. Alternative policy options have been proposed to promote high value and financially sustainable use of these therapies...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944686/remission-of-chronic-headache-rates-potential-predictors-and-the-role-of-medication-follow-up-results-of-the-german-headache-consortium-ghc-study
#4
Verena Henning, Zaza Katsarava, Mark Obermann, Susanne Moebus, Sara Schramm
Objectives To estimate remission rates of chronic headache (CH), focusing on potential predictors of headache remission and medication. Methods We used data from the longitudinal population-based German Headache Consortium (GHC) Study (n = 9,944, 18-65 years). Validated questionnaires were used at baseline (t0, 2003-2007, response rate: 55.2%), first follow-up after 1.87 ± 0.39 years (t1, 37.2%) and second follow-up after 3.26 ± 0.60 years (t2, 38.8%) to assess headache type and frequency, use of analgesics and anti-migraine drugs, medication overuse, education, BMI, smoking and alcohol consumption...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28944604/the-social-practice-of-medical-guanxi-personal-connections-and-patient-physician-trust-in-china-an-anthropological-and-ethical-tsudy
#5
Xiang Zou, Yu Cheng, Jing-Bao Nie
In China's healthcare sector, a popular and socio-culturally distinctive phenomenon known as guanxi jiuyi (medical guanxi), whereby patients draw on their guanxi (personal connections) with physicians when seeking healthcare, is thriving. Integrating anthropological investigation with normative inquiry, this paper examines medical guanxi through the lens of patient-physician trust and mistrust. The first-hand empirical data acquired - on the lived experiences and perspectives of both patients and physicians - is based on six months' fieldwork carried out in a county hospital in Guangdong, southern China, which included in-depth interviews with 20 patients and 20 medical professionals...
September 25, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28944467/olfactory-dysfunction-predicts-subsequent-dementia-in-older-u-s-adults
#6
Dara R Adams, David W Kern, Kristen E Wroblewski, Martha K McClintock, William Dale, Jayant M Pinto
OBJECTIVES: To investigate the relationship between olfactory dysfunction and subsequent diagnosis of dementia. DESIGN: Longitudinal study of a population representative of U.S. older adults. SETTING: Home interviews (National Social Life, Health, and Aging Project). PARTICIPANTS: Men and women aged 57 to 85 (N = 2,906). MEASUREMENTS: Objective odor identification ability was measured at baseline using a validated five-item test...
September 25, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28944163/weathering-the-storm-improving-therapeutic-interventions-for-cytokine-storm-syndromes-by-targeting-disease-pathogenesis
#7
Lehn K Weaver, Edward M Behrens
Cytokine storm syndromes require rapid diagnosis and treatment to limit the morbidity and mortality caused by the hyperinflammatory state that characterizes these devastating conditions. Herein, we discuss the current knowledge that guides our therapeutic decision-making and personalization of treatment for patients with cytokine storm syndromes. Firstly, ICU-level supportive care is often required to stabilize patients with fulminant disease while additional diagnostic evaluations proceed to determine the underlying cause of cytokine storm...
March 2017: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/28944007/the-other-white-nose-syndrome-transcriptome-tolerant-and-susceptible-hosts-respond-differently-to-the-pathogen-pseudogymnoascus-destructans
#8
Christina M Davy, Michael E Donaldson, Craig K R Willis, Barry J Saville, Liam P McGuire, Heather Mayberry, Alana Wilcox, Gudrun Wibbelt, Vikram Misra, Trent Bollinger, Christopher J Kyle
Mitigation of emerging infectious diseases that threaten global biodiversity requires an understanding of critical host and pathogen responses to infection. For multihost pathogens where pathogen virulence or host susceptibility is variable, host-pathogen interactions in tolerant species may identify potential avenues for adaptive evolution in recently exposed, susceptible hosts. For example, the fungus Pseudogymnoascus destructans causes white-nose syndrome (WNS) in hibernating bats and is responsible for catastrophic declines in some species in North America, where it was recently introduced...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28943987/hospital-discharge-what-are-the-problems-information-needs-and-objectives-of-community-pharmacists-a-mixed-method-approach
#9
Lea D Brühwiler, Kurt E Hersberger, Monika Lutters
BACKGROUND: After hospital discharge, community pharmacists are often the first health care professionals the discharged patient encounters. They reconcile and dispense prescribed medicines and provide pharmaceutical care. Compared to the roles of general practitioners, the pharmacists' needs to perform these tasks are not well known. OBJECTIVE: This study aims to a) Identify community pharmacists' current problems and roles at hospital discharge, b) Assess their information needs, specifically the availability and usefulness of information, and c) Gain insight into pharmacists' objectives and ideas for discharge optimisation...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28943986/medical-and-pharmacy-students-attitudes-towards-physician-pharmacist-collaboration-in-kuwait
#10
Maram G Katoue, Abdelmoneim I Awad, Aishah Al-Jarallah, Ebaa Al-Ozairi, Terry L Schwinghammer
OBJECTIVE: To assess and compare the attitudes of medical and pharmacy students towards physician-pharmacist collaboration and explore their opinions about the barriers to collaborative practice in Kuwait. METHODS: A cross-sectional survey of pharmacy and medical students (n=467) was conducted in Faculties of Medicine and Pharmacy, Kuwait University. Data were collected via self-administered questionnaire from first-year pharmacy and medical students and students in the last two professional years of the pharmacy and medical programs...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28943981/assessment-of-health-seeking-behaviour-and-self-medication-among-general-public-in-the-state-of-penang-malaysia
#11
Omar T Dawood, Mohamed A Hassali, Fahad Saleem, Inas R Ibrahim, Aseel H Abdulameer, Hanan H Jasim
BACKGROUND: Patients' behaviour in making decisions regarding health is currently changing from passive recipients to recipients who play an active role in taking action to control their health and taking self-care initiatives. OBJECTIVES: This study was conducted to evaluate the health seeking behaviour among general public and its associated factors; and to evaluate the medicine taking behaviour in public and the practice of self-medication. METHODS: A cross-sectional study was undertaken among general public in Penang Island, Malaysia...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28943642/neighborhood-attainment-over-the-adult-life-course
#12
Scott J South, Ying Huang, Amy Spring, Kyle Crowder
This study uses data from the Panel Study of Income Dynamics, in conjunction with neighborhood-level data from the U.S. decennial census and American Community Survey, to examine the trajectory of individuals' neighborhood characteristics from initial household formation into mid-to-late adulthood. Multilevel growth curve models reveal both different starting points and different life-course trajectories for blacks and whites in neighborhood economic status and neighborhood racial composition. Among respondents who first established an independent household during the 1970s, improvement in neighborhood income over the adult life course is substantially greater for whites than for blacks, while the racial difference in the percentage of neighbors who are non-Hispanic white narrows slightly with age...
December 2016: American Sociological Review
https://www.readbyqxmd.com/read/28943513/neonatal-diabetes-two-cases-with-isolated-pancreas-agenensis-due-to-homozygous-ptf1a-enhancer-mutations-and-one-with-dend-syndrome-due-to-kcnj11-mutation
#13
Olcay Evliyaoğlu, Oya Ercan, Emel Ataloğlu, Ümit Zübarioğlu, Bahar Özcabı, Aydilek Dağdeviren, Hande Erdoğan, Elisa De Franco, Sian Ellard
Neonatal diabetes mellitus is a rare form of monogenic diabetes which is diagnosed in the first 6 months of life. Here we report three patients with neonatal diabetes; two with isolated pancreas agenesis due to mutations in the PTF1A enhancer and one with DEND syndrome (developmental delay, epilepsy, and neonatal diabetes) due to a KCNJ11 mutation. The two cases with mutations in the distal enhacer of PTF1A had a homozygous g.23508363A>G and a homozygous g.23508437A>G mutation respectively. Previous functional analysis showed that these mutations can decrease expression of PTF1A which is involved in pancreas development...
September 25, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28943340/decoupling-brain-from-nerve-cord-development-in-the-annelid-capitella-teleta-insights-into-the-evolution-of-nervous-systems
#14
Allan M Carrillo-Baltodano, Néva P Meyer
In the deuterostomes and ecdysozoans that have been studied (e.g. chordates and insects), neural fate specification relies on signaling from surrounding cells. However, very little is known about mechanisms of neural specification in the third major bilaterian clade, spiralians. Using blastomere isolation in the annelid Capitella teleta, a spiralian, we studied to what extent extrinsic versus intrinsic signals are involved in early neural specification of the brain and ventral nerve cord. For the first time in any bilaterian, we found that brain neural ectoderm is autonomously specified...
September 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28943009/midterm-and-long-term-follow-up-in-competitive-athletes-undergoing-thoracic-outlet-decompression-for-neurogenic-thoracic-outlet-syndrome
#15
William Shutze, Brad Richardson, Ryan Shutze, Kimberly Tran, Allen Dao, Gerald O Ogola, Allan Young, Greg Pearl
BACKGROUND: Neurogenic thoracic outlet syndrome (NTOS) results from compression of the brachial plexus by the clavicle, first rib, and scalene muscles and may develop secondary to repetitive motion of the upper extremity. Athletes routinely perform repetitive motions, and sports requiring significant arm and shoulder use may put the participant at increased risk for NTOS. Competitive athletes who develop NTOS may require first rib resection and scalenectomy (FRRS) for symptomatic relief...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942849/analysis-of-the-pho-regulon-in-streptomyces-tsukubaensis
#16
María Ordóñez-Robles, Fernando Santos-Beneit, Antonio Rodríguez-García, Juan F Martín
Phosphate regulation of antibiotic biosynthesis in Streptomyces has been studied due to the importance of this genus as a source of secondary metabolites with biological activity. Streptomyces tsukubaensis is the main producer of tacrolimus (or FK506), an immunosuppressant macrolide that generates important benefits for the pharmaceutical market. However, the production of tacrolimus is under a negative control by phosphate and, therefore, is important to know the molecular mechanism of this regulation. Despite its important role, there are no reports about the Pho regulon in S...
December 2017: Microbiological Research
https://www.readbyqxmd.com/read/28942404/successful-treatment-using-rituximab-in-a-patient-with-refractory-polymyositis-complicated-by-scleroderma-renal-crisis
#17
Kyoko Innami, Tomoyuki Mukai, Shoko Kodama, Yoshitaka Morita
Corticosteroids are the first-line treatment for patients with inflammatory myopathies. Myositis can be a clinical feature of scleroderma (polymyositis-scleroderma overlap syndrome), and treatment of this syndrome is a challenge for clinicians because moderate to high doses of corticosteroids are considered a risk factor for development of acute kidney injury in affected patients. We report here the case of a 56-year-old woman with scleroderma who developed polymyositis and was successfully treated with rituximab...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942265/functionalization-of-single-solid-state-nanopores-to-mimic-biological-ion-channels-a-review
#18
REVIEW
Mathilde Lepoitevin, Tianji Ma, Mikhael Bechelany, Jean-Marc Janot, Sebastien Balme
In nature, ion channels are highly selective pores and act as gate to ensure selective ion transport, allowing ions to cross the membrane. By mimicking them, single solid state nanopore devices emerge as a new, powerful class of molecule sensors that allow for the label-free detection of biomolecules (DNA, RNA, and proteins), non-biological polymers, as well as small molecules. In this review, we exhaustively describe the fabrication and functionalization techniques to design highly robust and selective solid state nanopores...
September 14, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28942225/arthroscopic-deepening-trochleoplasty-for-chronic-anterior-knee-pain-after-previous-failed-conservative-and-arthroscopic-treatment-report-of-two-cases
#19
Lars Blønd
PURPOSE: A proportion of patients having years of chronic anterior knee pain(AKP) that have not responded to non-operative modalities. Trochlear dysplasia have been found to be a cause for AKP. By restoring the anatomy with a trochleoplasty procedure the patellofemoral joint is unloaded. This study is a prospective 2year follow-up study, based on two cases with chronic AKP for several years and having severe trochlear dysplasia and both were successfully treated by arthroscopic deepening trochleoplasty...
September 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28941954/a-parental-report-of-youth-transition-readiness-the-parent-starx-questionnaire-starx-p-and-re-evaluation-of-the-starx-child-report
#20
Meaghan Nazareth, Laura Hart, Maria Ferris, Eniko Rak, Stephen Hooper, Miranda A L van Tilburg
PURPOSE: The STARx Questionnaire is a self-report measure of health care transition (HCT) readiness in youth with chronic diseases. We aimed to improve reliability and generalizability of the STARx and report initial reliability data on the STARx-P Questionnaire, a self-report measure of parent perspective on their child's HCT readiness. METHODS: Participants were recruited in several clinics from a large academic hospital in the southeastern USA and via the therapeutic summer camp for children with chronic disease...
September 20, 2017: Journal of Pediatric Nursing
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