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https://www.readbyqxmd.com/read/29342393/hyperthermic-intraperitoneal-chemotherapy-in-ovarian-cancer
#1
Willemien J van Driel, Simone N Koole, Karolina Sikorska, Jules H Schagen van Leeuwen, Henk W R Schreuder, Ralph H M Hermans, Ignace H J T de Hingh, Jacobus van der Velden, Henriëtte J Arts, Leon F A G Massuger, Arend G J Aalbers, Victor J Verwaal, Jacobien M Kieffer, Koen K Van de Vijver, Harm van Tinteren, Neil K Aaronson, Gabe S Sonke
Background Treatment of newly diagnosed advanced-stage ovarian cancer typically involves cytoreductive surgery and systemic chemotherapy. We conducted a trial to investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery would improve outcomes among patients who were receiving neoadjuvant chemotherapy for stage III epithelial ovarian cancer. Methods In a multicenter, open-label, phase 3 trial, we randomly assigned 245 patients who had at least stable disease after three cycles of carboplatin (area under the curve of 5 to 6 mg per milliliter per minute) and paclitaxel (175 mg per square meter of body-surface area) to undergo interval cytoreductive surgery either with or without administration of HIPEC with cisplatin (100 mg per square meter)...
January 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29342380/e-cigarettes-and-the-harm-reduction-continuum
#2
Amy L Fairchild, Ju Sung Lee, Ronald Bayer, James Curran
On July 28, 2017, the recently appointed commissioner of the Food and Drug Administration (FDA), Scott Gottlieb, announced a "new comprehensive plan for tobacco and nicotine regulation." To permit both scientific deliberation and product innovation, the FDA will delay rules on the regulation of..
January 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29342320/association-of-pre-esrd-serum-calcium-with-post-esrd-mortality-among-incident-esrd-patients-a-cohort-study
#3
Yoshitsugu Obi, Christina Park, Melissa Soohoo, Keiichi Sumida, Takayuki Hamano, Connie M Rhee, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
Albumin-corrected serum calcium (cSCa) decline at late stages of chronic kidney disease and rise after dialysis initiation. While hypercalcemia is associated with higher mortality in end-stage renal disease (ESRD), there are scarce data on the impact of pre-ESRD cSCa on post-ESRD mortality. Therefore, we used a large national cohort of 21,826 US veterans with incident ESRD who transitioned to dialysis in all US Department of Veterans Affairs healthcare facilities over 2009-2014 to examine the associations with all-cause and cause-specific post-ESRD mortality of (1) cSCa concentrations averaged over the last six months and (2) its rate of decline during the last 12 months before dialysis initiation...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29342272/daily-decision-making-about-food-during-pregnancy-a-new-zealand-study
#4
Susan Pullon, Angela Ballantyne, Lindsay Macdonald, Christine Barthow, Kristin Wickens, Julian Crane
Pregnancy has always been a life-changing event for women and their families, but societal concern about pregnancy and motherhood has become intense in the digital age. The role of health promotion agencies and others supplying health-related resources about lifestyle behaviours is both important and in need of scrutiny. Ever increasing advice for pregnant women, their families and health professionals, abounds. This study of decision making during pregnancy investigated how women made everyday decisions during pregnancy about food and drink, as well as dietary supplements and medications, alcohol and recreational drugs...
January 12, 2018: Health Promotion International
https://www.readbyqxmd.com/read/29341890/periodontal-diseases-and-adverse-pregnancy-outcomes-is-there-a-role-for-vitamin-d
#5
REVIEW
Anne Marie Uwitonze, Peace Uwambaye, Moses Isyagi, Chrispinus H Mumena, Alice Hudder, Afrozul Haq, Kamrun Nessa, Mohammed S Razzaque
Studies have shown a relationship between maternal periodontal diseases (PDs) and premature delivery. PDs are commonly encountered oral diseases which cause progressive damage to the periodontal ligament and alveolar bones, leading to loss of teeth and oral disabilities. PDs also adversely affect general health by worsening cardiovascular and metabolic diseases. Moreover, maternal PDs are thought to be related to increasing the frequency of preterm-birth with low birth weight (PBLBW) new-borns. Prematurity and immaturity are the leading causes of prenatal and infant mortality and is a major public health problem around the world...
January 13, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29341525/-general-internal-medicine%C3%A2-2017-scientific-breakthroughs-in-ambulatory-care
#6
Alexandre Gouveia, Lionel De Alencastro, Yvonne Fierz, Lionel Koehli, Alexandre Béguelin, Olivier Pasche, Kevin Selby, Patrick Bodenmann
Bariatric surgery improves glycemic control in obese patients with diabetes type 2. Dual antiplatelet therapy can be maintained beyond 12 months after a myocardial infarction. Levothyroxine is not beneficial among patients ≥ 65 years that have subclinical hypothyroidism. Prophylactic anticoagulation in lower limb immobilisation should be reserved only for patients with a high risk of thromboembolism. A diagnosis of asthma should be initially confirmed by a spirometry if clinically suspected. A proton pump inhibitor is indicated for patients ≥ 65 years that are treated with aspirin...
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29341199/timing-of-gamma-irradiation-and-blood-donor-sex-influences-in-vitro-characteristics-of-red-blood-cells
#7
Dirk de Korte, Louis Thibault, Wiebke Handke, Sarah K Harm, Alex Morrison, Aine Fitzpatrick, Denese C Marks, Qi-Long Yi, Jason P Acker
BACKGROUND: There are few studies investigating the effect of irradiation on red blood cells (RBCs) during storage. This study analyzed changes in in vitro quality of RBCs irradiated at several points during storage with the aim of providing evidence to support current maximum pre- and postirradiation storage limits. STUDY DESIGN AND METHODS: Each of seven participating centers produced four pools of 7 standard RBC units (SAGM, AS-3, or PAGGSM), which were then split back into 7 units...
January 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29341193/impact-of-trans-fats-on-heat-shock-protein-expression-and-the-gut-microbiota-profile-of-mice
#8
Gessika Cristina Borges Castro Carvalho, Carolina Soares Moura, Aline Rissetti Roquetto, Daniel Barrera-Arellano, Aureo Tatsumi Yamada, Andrey Dos Santos, Mário José Abdalla Saad, Jaime Amaya-Farfan
Partially hydrogenated oils are known to cause metabolic stress and dyslipidemia. This paper explores a new dimension about the interaction between dietary trans-fats and the defense heat-shock protein (HSP) system, inflammation, and the gut microbiota of mice consuming a hyperlipidic diet containing partially hydrogenated vegetable oil free of animal fat. Five diet groups were installed: control diet, 2 hyperlipidic-partially hydrogenated-oil diets, each containing either casein or whey-protein hydrolysate (WPH) as protein source, and 2 consuming hyperlipidic-unhydrogenated-oil diets containing either WPH or casein as a protein source...
January 17, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29339468/molecular-epidemiology-reveals-the-role-of-war-in-the-spread-of-hiv-in-ukraine
#9
Tetyana I Vasylyeva, Mariia Liulchuk, Samuel R Friedman, Iana Sazonova, Nuno R Faria, Aris Katzourakis, Nataliia Babii, Alla Scherbinska, Julien Thézé, Oliver G Pybus, Pavlo Smyrnov, Jean L Mbisa, Dimitrios Paraskevis, Angelos Hatzakis, Gkikas Magiorkinis
Ukraine has one of the largest HIV epidemics in Europe, historically driven by people who inject drugs (PWID). The epidemic showed signs of stabilization in 2012, but the recent war in eastern Ukraine may be reigniting virus spread. We investigated the movement of HIV-infected people within Ukraine before and during the conflict. We analyzed HIV-1 subtype-A pol nucleotide sequences sampled during 2012-2015 from 427 patients of 24 regional AIDS centers and used phylogeographic analysis to reconstruct virus movement among different locations in Ukraine...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29339405/health-care-professionals-neckties-as-a-source-of-transmission-of-bacteria-to-patients-a-systematic-review
#10
Pia Pace-Asciak, Sanjiv K Bhimrao, Frederick K Kozak, Brian D Westerberg
BACKGROUND: There is growing concern that neckties worn by health care professionals may contribute to infections contracted in health care settings. We evaluated the evidence for health-care-associated infections resulting from neckties and whether the evidence is sufficient to warrant a tieless policy in Canada. METHODS: We performed a systematic review to determine whether neckties worn by health care professionals colonize harmful pathogenic bacteria and whether they contribute to the spread of infection to patients in the inpatient or outpatient setting...
January 12, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29339387/the-genetic-basis-of-emerging-vancomycin-linezolid-and-daptomycin-heteroresistance-in-a-case-of-persistent-enterococcus-faecium-bacteremia
#11
Kieran Chacko, Mitchell Sullivan, Colleen Beckford, Deena Altman, Brianne Ciferri, Theodore Pak, Robert Sebra, Andrew Kasarskis, Camille Hamula, Harm van Bakel
Whole-genome sequencing was used to examine a persistent E. faecium bacteremia that acquired heteroresistance to three antibiotics in response to prolonged multidrug therapy. Comparison of complete genomes before and after each change revealed the emergence of known resistance determinants for vancomycin and linezolid, and suggested that a novel mutation in fabF, encoding a fatty acid synthase, was responsible for daptomycin nonsusceptibility. Plasmid recombination contributed to progressive loss of vancomycin resistance after withdrawal of the drug...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29339305/modelling-ros-formation-in-boreal-lakes-from-interactions-between-dissolved-organic-matter-and-absorbed-solar-photon-flux
#12
Raoul Wolf, Jan-Erik Thrane, Dag Olav Hessen, Tom Andersen
Concentrations of dissolved organic matter (DOM) are increasing in a large number of lakes across the Northern hemisphere. This browning serves a dual role for biota by protecting against harmful ultraviolet radiation, while also absorbing photosynthetically active radiation. The photochemical activation of DOM and subsequent formation of reactive oxygen species (ROS) is a potentially harmful side effect, but can be difficult to measure directly in situ. In this study, we combine a data set of physico-chemical properties from 71 Nordic lakes with in vitro ROS formation quantum yields to predict ROS formations across a representative boreal ecosystem gradient...
January 11, 2018: Water Research
https://www.readbyqxmd.com/read/29338881/infiltration-behaviour-of-elemental-mercury-dnapl-in-fully-and-partially-water-saturated-porous-media
#13
Andrea D'Aniello, Niels Hartog, Thomas Sweijen, Domenico Pianese
Mercury is a contaminant of global concern due to its harmful effects on human health and for the detrimental consequences of its release in the environment. Sources of liquid elemental mercury are usually anthropogenic, such as chlor-alkali plants. To date insight into the infiltration behaviour of liquid elemental mercury in the subsurface is lacking, although this is critical for assessing both characterization and remediation approaches for mercury DNAPL contaminated sites. Therefore, in this study the infiltration behaviour of elemental mercury in fully and partially water saturated systems was investigated using column experiments...
January 8, 2018: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29338800/a-preliminary-investigation-of-pathways-to-inflated-responsibility-beliefs-in-children-with-obsessive-compulsive-disorder
#14
Lindsey M Collins, Meredith E Coles
BACKGROUND: Cognitive theorists posit that inflated responsibility beliefs contribute to the development of obsessive compulsive disorder (OCD). Salkovskis et al. (1999) proposed that experiencing heightened responsibility, overprotective parents and rigid rules, and thinking one influenced or caused a negative life event act as 'pathways' to the development of inflated responsibility beliefs, thereby increasing risk for OCD. Studies in adults with OCD and non-clinical adolescents support the link between these experiences and responsibility beliefs (Coles et al...
January 17, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29338558/the-influence-of-masculine-norms-and-occupational-factors-on-mental-health-evidence-from-the-baseline-of-the-australian-longitudinal-study-on-male-health
#15
Allison Milner, Anne Kavanagh, Tania King, Dianne Currier
Men employed in male-dominated occupations are at elevated risk of work-related fatalities, injuries, and suicide. Prior research has focused on associations between psychosocial and physical exposures at work and health outcomes. However, masculine norms may also contribute to mental health. We used data from the baseline survey of the Australian Longitudinal Study on Male Health to examine whether: (a) men in male-dominated jobs report greater adherence to masculine norms; (b) being in a male-dominated occupation is associated with poorer mental health; and (c) being in a male-dominated occupation modifies the association between masculine norms and mental health...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29338427/lipid-nanoparticles-for-intranasal-administration-application-to-nose-to-brain-delivery
#16
Luigi Battaglia, Pier Paolo Panciani, Elisabetta Muntoni, Maria Teresa Capucchio, Elena Biasibetti, Pasquale De Bonis, Silvia Mioletti, Marco Fontanella, Shankar Swaminathan
The blood brain barrier is a functional barrier allowing the entry into the brain of only essential nutrients, excluding other molecules. Its structure, although essential to keep the harmful entities out, is also a major roadblock for pharmacological treatment of brain diseases. Several alternative invasive drug delivery approaches, such as transcranial drug delivery and disruption of blood brain barrier have been explored, with limited success and several challenges. Intranasal delivery is a non-invasive methodology, which bypasses the systemic circulation, and, through the intra- and extra- neuronal pathways, provides direct brain drug delivery...
January 17, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29338138/could-cryopreserved-human-semen-samples-be-stored-at-80%C3%A2-c
#17
Carlos R Vaz, Tamara Lamim, Rafael A Salvador, Anna P B Batschauer, Vera Lucia L Amaral, David Til
OBJECTIVE: To evaluate storage time effects in cryopreserved human semen samples, kept in the freezer at a controlled temperature of -80°C, on sperm viability after thawing. METHODS: We used 20 semen samples. Each sample was cryopreserved in 10 fingers, which were divided into five groups: one group was kept in cryogenic canisters throughout the experiment(control), and four groups were kept in a VIP Ultra Low MDF-U76V- PE freezer, with the temperature set at -80°C, for 24, 48, 72 and 96 hours, respectively...
January 17, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29338118/impact-of-quality-of-research-on-patient-outcomes-in-the-institute-of-medicine-2013-report-on-dietary-sodium
#18
Aaron Lucko, Chelsea Ta Doktorchik, Norm Rc Campbell
The 2013 Institute of Medicine report entitled "Sodium Intake in Populations: Assessment of Evidence" found inconsistent evidence of health benefit with dietary sodium intake <2300 mg/d. Different studies reported benefit and harm of population dietary intake <2300 mg/d. The Institute of Medicine committee, however, did not assess whether the methodology used in each of the studies was appropriate to examine dietary sodium and health outcomes. This review investigates the association of methodological rigor and outcomes of studies in the Institute of Medicine report...
January 16, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29338042/a-pharmacological-screen-for-compounds-that-rescue-the-developmental-lethality-of-a-drosophila-atm-mutant
#19
Stacey A Rimkus, David A Wassarman
Ataxia-telangiectasia (A-T) is a neurodegenerative disease caused by mutation of the A-T mutated (ATM) gene. ATM encodes a protein kinase that is activated by DNA damage and phosphorylates many proteins, including those involved in DNA repair, cell cycle control, and apoptosis. Characteristic biological and molecular functions of ATM observed in mammals are conserved in Drosophila melanogaster. As an example, conditional loss-of-function ATM alleles in flies cause progressive neurodegeneration through activation of the innate immune response...
2018: PloS One
https://www.readbyqxmd.com/read/29337890/subcellular-reactive-oxygen-species-ros-in-cardiovascular-pathophysiology
#20
REVIEW
Sarah Aldosari, Maan Awad, Elizabeth O Harrington, Frank W Sellke, M Ruhul Abid
There exist two opposing perspectives regarding reactive oxygen species (ROS) and their roles in angiogenesis and cardiovascular system, one that favors harmful and causal effects of ROS, while the other supports beneficial effects. Recent studies have shown that interaction between ROS in different sub-cellular compartments plays a crucial role in determining the outcomes (beneficial vs. deleterious) of ROS exposures on the vascular system. Oxidant radicals in one cellular organelle can affect the ROS content and function in other sub-cellular compartments in endothelial cells (ECs)...
January 16, 2018: Antioxidants (Basel, Switzerland)
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