keyword
MENU ▼
Read by QxMD icon Read
search

Harm

keyword
https://www.readbyqxmd.com/read/27906117/carotid-artery-stenting-versus-no-stenting-assisting-thrombectomy-for-acute-ischaemic-stroke-protocol-for-a-systematic-review-of-randomised-clinical-trials-with-meta-analyses-and-trial-sequential-analyses
#1
Henrik Steglich-Arnholm, Markus Holtmannspötter, Christian Gluud, Derk Wolfgang Krieger
BACKGROUND: In patients with intracranial large vessel arterial occlusion, ipsilateral extracranial carotid artery occlusions or near-occlusions pose a significant hurdle in endovascular management of acute ischaemic stroke. Stenting of the carotid lesion may be beneficial in this situation to provide a stable access for introducing catheters through the carotid lesion into the intracranial vasculature and the target occlusion. Furthermore, carotid stenting may ensure ample blood flow for wash-out of clot material and reperfusion of the ischaemic penumbral tissue...
December 1, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27906064/treatment-with-rgdf11-does-not-improve-the-dystrophic-muscle-pathology-of-mdx-mice
#2
Fabrizio Rinaldi, Yu Zhang, Ricardo Mondragon-Gonzalez, Jeffrey Harvey, Rita C R Perlingeiro
BACKGROUND: Duchenne muscular dystrophy (DMD) is an inherited lethal muscle wasting disease characterized by cycles of degeneration and regeneration, with no effective therapy. Growth differentiation factor 11 (GDF11), a member of the TGF-β superfamily and myostatin homologous, has been reported to have the capacity to reverse age-related skeletal muscle loss. These initial findings led us to investigate the ability of GDF11 to promote regeneration in the context of muscular dystrophy and determine whether it could be a candidate to slow down or reverse the disease progression in DMD...
June 14, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27905988/a-population-study-on-the-time-trend-of-cigarette-smoking-cessation-and-exposure-to-secondhand-smoking-from-2001-to-2013-in-taiwan
#3
Chi-Yung Chiang, Hsing-Yi Chang
BACKGROUND: In 2001, the National Health Interview Survey (NHIS) commenced in Taiwan. This survey, conducted on a sample of the whole Taiwanese population, is nationally representative and has a high response rate (>80 %). As a result, the four already completed surveys from 2001 to 2013 can be used to investigate the time trend of smoking prevalence, the rate of cessation, and exposure to secondhand smoking. METHODS: There were 72918 adults combined from the 2001, 2005, 2009 and 2013 National Health Interview Surveys (NHIS)...
November 5, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905976/comparative-approaches-for-assessing-access-to-alcohol-outlets-exploring-the-utility-of-a-gravity-potential-approach
#4
Tony H Grubesic, Ran Wei, Alan T Murray, William Alex Pridemore
BACKGROUND: A growing body of research recommends controlling alcohol availability to reduce harm. Various common approaches, however, provide dramatically different pictures of the physical availability of alcohol. This limits our understanding of the distribution of alcohol access, the causes and consequences of this distribution, and how best to reduce harm. The aim of this study is to introduce both a gravity potential measure of access to alcohol outlets, comparing its strengths and weaknesses to other popular approaches, and an empirically-derived taxonomy of neighborhoods based on the type of alcohol access they exhibit...
August 2, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905935/development-of-a-filter-to-prevent-infections-with-spore-forming-bacteria-in-injecting-drug-users
#5
Nour Alhusein, Jenny Scott, Barbara Kasprzyk-Hordern, Albert Bolhuis
BACKGROUND: In heroin injectors, there have been a number of outbreaks caused by spore-forming bacteria, causing serious infections such as anthrax or botulism. These are, most likely, caused by injecting contaminated heroin, and our aim was to develop a filter that efficiently removes these bacteria and is also likely to be acceptable for use by people who inject drugs (i.e. quick, simple and not spoil the hit). METHODS: A prototype filter was designed and different filter membranes were tested to assess the volume of liquid retained, filtration time and efficiency of the filter at removing bacterial spores...
December 1, 2016: Harm Reduction Journal
https://www.readbyqxmd.com/read/27905877/mineralocorticoid-receptor-antagonists-for-heart-failure-systematic-review-and-meta-analysis
#6
Nicolas M Berbenetz, Marko Mrkobrada
BACKGROUND: Mineralocorticoid receptor antagonists (MRAs) have been associated with improved patient outcomes in patients with heart failure with reduced ejection fraction (HFrEF) but not preserved ejection fraction (HFpEF). We conducted a systematic review and meta-analysis of selective and nonselective MRAs in HFrEF and HFpEF. METHODS: We searched Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE. We included randomized controlled trials (RCT) of MRAs in adults with HFpEF or HFrEF if they reported data on major adverse cardiac events or drug safety...
December 1, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27905479/role-of-gut-microbiota-in-atherosclerosis
#7
REVIEW
Annika Lindskog Jonsson, Fredrik Bäckhed
Infections have been linked to the development of cardiovascular disease and atherosclerosis. Findings from the past decade have identified microbial ecosystems residing in different habitats of the human body that contribute to metabolic and cardiovascular-related disorders. In this Review, we describe three pathways by which microbiota might affect atherogenesis. First, local or distant infections might cause a harmful inflammatory response that aggravates plaque development or triggers plaque rupture. Second, metabolism of cholesterol and lipids by gut microbiota can affect the development of atherosclerotic plaques...
December 1, 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27905098/are-neutrophilic-dermatoses-autoinflammatory-disorders
#8
REVIEW
T K Satoh, M Mellett, E Contassot, L E French
Neutrophils constitute essential players in inflammatory responses and are the first line of defence against harmful stimuli. However, dysregulation of neutrophil homeostasis can result in excessive inflammation and subsequent tissue damage. Neutrophilic dermatoses are a spectrum of inflammatory disorders characterized by skin lesions resulting from a neutrophil-rich inflammatory infiltrate in the absence of infection. The exact molecular pathophysiology of neutrophilic dermatoses has long been poorly understood...
November 30, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27905075/a-description-of-medication-errors-reported-by-pharmacists-in-a-neonatal-intensive-care-unit
#9
Shane Pawluk, Myriam Jaam, Fatima Hazi, Moza Sulaiman Al Hail, Wessam El Kassem, Hanan Khalifa, Binny Thomas, Pallivalappila Abdul Rouf
Background Patients in the Neonatal Intensive Care Unit (NICU) are at an increased risk for medication errors. Objective The objective of this study is to describe the nature and setting of medication errors occurring in patients admitted to an NICU in Qatar based on a standard electronic system reported by pharmacists. Setting Neonatal intensive care unit, Doha, Qatar. Method This was a retrospective cross-sectional study on medication errors reported electronically by pharmacists in the NICU between January 1, 2014 and April 30, 2015...
November 30, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27905072/communicating-uncertainty-in-benefits-and-harms-a-review-of-patient-decision-support-interventions
#10
Nick Bansback, Madelaine Bell, Luke Spooner, Alysa Pompeo, Paul K J Han, Mark Harrison
BACKGROUND: Interventions designed to help people deliberate and participate in their healthcare choices frequently describe uncertainty in potential benefits and harms. This uncertainty can be generalized to aleatory, or first-order uncertainty, represented by risk estimates, and epistemic, or second-order uncertainty, represented by imprecision in the risk estimates. OBJECTIVES: The aim of this short communication was to review how patient decision support interventions (PDSIs) describe aleatory and epistemic uncertainty...
November 30, 2016: Patient
https://www.readbyqxmd.com/read/27904166/iris-an-internet-based-intervention-as-a-suitable-path-to-addictive-substance-use-prevention-and-counselling-in-pregnancy-beneficiary-profiles-and-user-satisfaction
#11
A Stiegler, H Abele, A Batra
Alcohol or tobacco consumption in pregnancy can harm the unborn child. Counselling on this subject is therefore of major importance. The aim of the presented study was not only to develop an internet based, professionally e-mail accompanied platform for alcohol or tobacco consuming pregnant women ("IRIS Platform") but also to analyse the beneficiary profiles and investigate the practicability and acceptance of the platform among women and referring gynaecologists. The offer comprised three 12-week counselling programmes (alcohol, tobacco, combined consumption)...
November 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27903957/medicalisation-smoking-and-e-cigarettes-evidence-and-implications
#12
Kylie Morphett, Adrian Carter, Wayne Hall, Coral Gartner
There is debate in the tobacco control literature about the value of a medical model in reducing smoking-related harm. The variety of medical treatments for smoking cessation has increased, health professionals are encouraged to use them to assist smoking cessation and tobacco dependence is being described as a 'chronic disease'. Some critics suggest that the medicalisation of smoking undermines the tobacco industry's responsibility for the harms of smoking. Others worry that it will lead smokers to deny personal responsibility for cessation, create beliefs in 'magic bullets' for smoking cessation, or erode smokers' confidence in their ability to quit...
November 30, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27903826/synthetic-biology-approaches-to-biological-containment-pre-emptively-tackling-potential-risks
#13
REVIEW
Leticia Torres, Antje Krüger, Eszter Csibra, Edoardo Gianni, Vitor B Pinheiro
Biocontainment comprises any strategy applied to ensure that harmful organisms are confined to controlled laboratory conditions and not allowed to escape into the environment. Genetically engineered microorganisms (GEMs), regardless of the nature of the modification and how it was established, have potential human or ecological impact if accidentally leaked or voluntarily released into a natural setting. Although all evidence to date is that GEMs are unable to compete in the environment, the power of synthetic biology to rewrite life requires a pre-emptive strategy to tackle possible unknown risks...
November 30, 2016: Essays in Biochemistry
https://www.readbyqxmd.com/read/27903725/hippocampal-damage-increases-deontological-responses-during-moral-decision-making
#14
Cornelia McCormick, Clive R Rosenthal, Thomas D Miller, Eleanor A Maguire
: Complex moral decision making is associated with the ventromedial prefrontal cortex (vmPFC) in humans, and damage to this region significantly increases the frequency of utilitarian judgments. Since the vmPFC has strong anatomical and functional links with the hippocampus, here we asked how patients with selective bilateral hippocampal damage would derive moral decisions on a classic moral dilemmas paradigm. We found that the patients approved of the utilitarian options significantly less often than control participants, favoring instead deontological responses-rejecting actions that harm even one person...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903686/adding-complexity-to-plexogenic-arteriopathy
#15
EDITORIAL
Norbert F Voelkel, Harm Jan Bogaard
No abstract text is available yet for this article.
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27903588/discovery-and-validation-of-agonistic-angiotensin-receptor-autoantibodies-as-biomarkers-of-adverse-outcomes
#16
Peter Abadir, Alka Jain, Laura Powell, Qian-Li Xue, Jing Tian, Robert G Hamilton, David Bennett, Thomas Finucane, Jeremy D Walston, Neal S Fedarko
BACKGROUND: -Agonistic angiotensin II type I receptor autoantibodies (AT1RaAbs) have not been associated with functional measures or risk for adverse health outcomes. AT1RaAbs could be utilized to stratify patient risk and to identify patients who can benefit from angiotensin receptor blocker (ARB) treatment. METHODS: -Demographic and physiologic covariates were measured in a discovery set of community dwelling adults from Baltimore (N=255) and AT1RaAb associations with physical function tests and outcomes assessed...
November 30, 2016: Circulation
https://www.readbyqxmd.com/read/27903582/threshold-levels-of-extracellular-l-arginine-that-trigger-nos-mediated-ros-rns-production-in-cardiac-ventricular-myocytes
#17
Jayalakshmi Ramachandran, R Daniel Peluffo
L-arginine (L-Arg) is the substrate for nitric oxide synthase (NOS) to produce nitric oxide (NO), a signaling molecule that is key in cardiovascular physiology and pathology. In cardiac myocytes, L-Arg is incorporated from the circulation through the functioning of system-y(+) cationic amino acid transporters. Depletion of L-Arg leads to NOS uncoupling, with O2 rather than L-Arg as terminal electron acceptor, resulting in superoxide formation. The reactive oxygen species (ROS) superoxide (O2•(-)), combined with NO, may lead to the production of the reactive nitrogen species (RNS) peroxynitrite (ONOO-), which is recognized as a major contributor to myocardial depression...
November 30, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27903519/dairy-intake-and-fecundability-in-2-preconception-cohort-studies
#18
Lauren A Wise, Amelia K Wesselink, Ellen M Mikkelsen, Heidi Cueto, Kristen A Hahn, Kenneth J Rothman, Katherine L Tucker, Henrik Toft Sørensen, Elizabeth E Hatch
BACKGROUND: Animal studies have shown that a high intake of galactose, a breakdown product of lactose, increases ovarian toxicity. Few epidemiologic studies, to our knowledge, have examined the association between dairy intake and fertility, and they have had conflicting findings. OBJECTIVE: We prospectively evaluated dairy intake in relation to fecundability among women who were planning for pregnancy. DESIGN: Data were derived from preconception cohort studies in Denmark (Snart Foraeldre) and North America [PRESTO (Pregnancy Study Online)] in which women completed a validated food-frequency questionnaire 10 d after enrollment...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27903482/systematic-review-and-meta-analysis-of-pre-operative-risk-factors-of-type-ii-endoleaks-after-endovascular-aneurysm-repair
#19
REVIEW
Florent Lalys, Vincent Durrmann, Aurélien Duménil, Cemil Göksu, Alain Cardon, Elodie Clochard, Antoine Lucas, Adrien Kaladji
PURPOSE: Type II endoleaks (T2Es) remain the Achilles heel of Endovascular Aneurysm Repair (EVAR), involving a close follow-up and sometimes leading to reintervention. Identifying risk factors impacting T2Es is of concern to improve decision-making and optimize follow-up. However, it has led to contradictory results, with supporting evidence for the majority of factors being weak. METHODS: A systematic review and meta-analysis was conducted to study risk factors of T2Es following EVAR to identify risk factors and measure their dedicated strength of association...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27903474/functional-assessment-and-evaluation-of-outcome-after-endovascular-therapy-with-coverage-of-the-left-subclavian-artery-in-case-of-blunt-thoracic-aortic-injury
#20
A Gombert, D Kotelis, U M Griepenkerl, G Fraedrich, J Klocker, B Glodny, M J Jacobs, A Greiner, J Grommes
OBJECTIVE: Patients suffering blunt thoracic aortic injury (BTAI) can be treated by use of thoracic endovascular aortic repair (TEVAR). In this setting, the coverage of the left subclavian artery (LSA) is frequently necessary. Nevertheless, the functionality of the upper left extremity after TEVAR had been rarely analyzed. Thus this study intends to underline the safety of TEVAR as well as to determine the functionality of the left arm after coverage of the LSA. METHODS: All patients suffering from BTAI treated by endovascular means in three centers (Aachen [Germany], Maastricht [Netherlands] and Innsbruck [Austria]) between 1996 and 2009 were retrospectively analyzed...
November 26, 2016: Annals of Vascular Surgery
keyword
keyword
1750
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"