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https://www.readbyqxmd.com/read/28735528/lipids-evergreen-autofluorescent-biomarkers-for-the-liver-functional-profiling
#1
Anna Cleta Croce, Giovanni Bottiroli
Depending on their chemical nature, lipids can be classified in two main categories: hydrophilic, greatly contributing to membrane composition and subcellular organelle compartmentalization, and hydrophobic, mostly triglycerides, greatly enrolled in the storage and production of energy. In both cases, some lipid molecules can be involved as signaling agents in the regulation of metabolism and protective or damaging pathways in responses to harmful stimuli. These events could affect in particular the liver, because of its central role in the maintenance of lipid homeostasis...
June 1, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735473/low-concentration-bpaf-and-bpf-induced-cell-biological-effects-are-mediated-by-ros-in-mcf-7-breast-cancer-cells
#2
Bingli Lei, Su Sun, Jie Xu, Chenglian Feng, Yingxin Yu, Gang Xu, Minghong Wu, Wei Peng
Reactive oxygen species (ROS) induced by bisphenol A (BPA) have been implicated in cellular oxidative damage and carcinogenesis. It is not known whether the potential alternatives of BPA, bisphenol AF (BPAF), and bisphenol F (BPF) can also induce ROS involved in mediating biological responses. This study evaluated the toxicity of BPAF and BPF on cell proliferation, DNA damage, intracellular calcium homeostasis, and ROS generation in MCF-7 human breast cancer cells. The results showed that BPAF at 0.001-1 μM and BPF at 0...
July 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28735331/evaluation-of-the-levels-and-quality-of-microbial-contamination-in-medical-emergency-departments-in-comparison-to-other-workplaces
#3
Agata Bielawska-Drózd, Bożena Wlizło-Skowronek, Piotr Cieślik, Izabela Winnicka, Ewa Skopińska-Różewska, Leszek Kubiak, Dorota Żakowska, Aleksandra Brewczyńska, Janusz Kocik
Work in Hospital Emergency Departments (HEDs) exposes both the emergency ward staff and patients to infectious and in other way harmful biological agents. The results of this study shows the presence of pathogenic bacteria isolated by three different methods. It revealed 9.8% of pathogens detected by imprint method, 10.5% of pathogens by swabbing method, 17.6% and 22% in HEDs corridors and rooms, respectively, by air sampling method. In control workplaces (offices) pathogenic bacteria reached the level of 6...
January 2, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28735272/perceived-nicotine-content-of-reduced-nicotine-content-cigarettes-is-a-correlate-of-perceived-health-risks
#4
Lauren R Pacek, F Joseph McClernon, Rachel L Denlinger-Apte, Melissa Mercincavage, Andrew A Strasser, Sarah S Dermody, Ryan Vandrey, Tracy T Smith, Natalie Nardone, Dorothy K Hatsukami, Joseph S Koopmeiners, Rachel V Kozink, Eric C Donny
BACKGROUND: Reducing cigarette nicotine content may reduce smoking. Studies suggest that smokers believe that nicotine plays a role in smoking-related morbidity. This may lead smokers to assume that reduced nicotine means reduced risk, and attenuate potential positive effects on smoking behaviour. METHODS: Data came from a multisite randomised trial in which smokers were assigned to use cigarettes varying in nicotine content for 6 weeks. We evaluated associations between perceived and actual nicotine content with perceived health risks using linear regression, and associations between perceived nicotine content and perceived health risks with smoking outcomes using linear and logistic regression...
July 22, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28735236/oxidation-of-tris-2-chloroethyl-phosphate-in-aqueous-solution-by-uv-activated-peroxymonosulfate-kinetics-water-matrix-effects-degradation-products-and-reaction-pathways
#5
Xinxin Xu, Jing Chen, Ruijuan Qu, Zunyao Wang
The feasibility of UV-activated peroxymonosulfate (PMS) technology for the degradation of Tris (2-chloroethyl) phosphate (TCEP) in an aqueous solution was investigated in this study. The conditions of [PMS]0: [TCEP]0 = 20:1, T = 25 ± 2 °C and pH = 5.5 ± 0.5 cause a 94.6% removal of TCEP (1 mg L(-1)) after 30 min of Hg lamp irradiation. The effects of operating parameters (the oxidant doses, pH and presence of typical cations (Fe(3+), Cu(2+), Ni(2+), NH4(+)), anions (Cl(-), HCO3(-), NO3(-), HPO4(2-)) and humic acid (HA)) were evaluated...
July 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28735092/rodenticide-incidents-of-exposure-and-adverse-effects-on-non-raptor-birds
#6
Nimish B Vyas
Interest in the adverse effects of rodenticides on birds has focused primarily on raptors. However, non-raptor birds are also poisoned (rodenticide exposure resulting in adverse effects including mortality) by rodenticides through consumption of the rodenticide bait and contaminated prey. A literature search for rodenticide incidents (evidence of exposure to a rodenticide, adverse effects, or exposure to placebo baits) involving non-raptor birds returned 641 records spanning the years 1931 to 2016. The incidents included 17 orders, 58 families, and 190 non-raptor bird species...
July 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28735028/protein-only-antimicrobial-peptide-containing-recombinant-nanoparticles-with-inherent-built-in-antibacterial-activity
#7
Naroa Serna, Laura Sánchez-García, Alejandro Sánchez-Chardi, Ugutz Unzueta, Mónica Roldán, Ramón Mangues, Esther Vázquez, Antonio Villaverde
The emergence of bacterial antibiotic resistances is a serious concern in human and animal health. In this context, naturally occurring cationic antimicrobial peptides (AMPs) might play a main role in a next generation of drugs against bacterial infections. Taking an innovative approach to design self-organizing functional proteins, we have generated here protein-only nanoparticles with intrinsic AMP microbicide activity. Using a recombinant version of the GWH1 antimicrobial peptide as building block, these materials show a wide antibacterial activity spectrum in absence of detectable toxicity on mammalian cells...
July 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28734786/clinical-usefulness-of-tools-to-support-decision-making-for-palliative-treatment-of%C3%A2-metastatic-colorectal-cancer-a-systematic-review
#8
Ellen G Engelhardt, Dóra Révész, Hans J Tamminga, Cornelis J A Punt, Mirjam Koopman, Bregje D Onwuteaka-Philipsen, Ewout W Steyerberg, Ilse P Jansma, Henrica C W De Vet, Veerle M H Coupé
BACKGROUND: Decision-making regarding palliative treatment for patients with metastatic colorectal cancer (mCRC) is complex and comprises numerous decisions. Decision-making should be guided by the premise of maintaining and/or improving patients' quality of life, by patient preference, and by the trade-off between treatment benefits and harm. Decision support systems (DSSs) for clinicians (eg, nomograms) can assist in this process. The present systematic review aimed to provide a comprehensive overview of the available DSSs for incurable mCRC and to assess their clinical usefulness...
June 24, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28734731/postnatal-corticosteroids-to-prevent-or-treat-bronchopulmonary-dysplasia-who-might-benefit
#9
REVIEW
Lex W Doyle, Jeanie L Y Cheong
Newborn infants born very preterm are at high risk of developing bronchopulmonary dysplasia, which is associated with not only mortality but also adverse long-term neurological and respiratory outcomes in survivors. Postnatal corticosteroids might reduce the risk of developing bronchopulmonary dysplasia, or reduce its severity. However, it is important to minimize exposure to the potentially harmful effects of corticosteroids, particularly on the developing brain. Systemic corticosteroids started after the first week of life have shown the most benefit in infants at highest risk of developing bronchopulmonary dysplasia, whereas inhaled corticosteroids have little effect in children with established lung disease...
July 19, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28734603/determination-of-volatile-organic-compounds-in-pen-inks-by-a-dynamic-headspace-needle-trap-device-combined-with-gas-chromatography-mass-spectrometry
#10
Xiaohuan Zang, Weiqian Liang, Qingyun Chang, Tong Wu, Chun Wang, Zhi Wang
Some harmful volatile organic compounds (VOCs), such as methylbenzene, ethylbenzene, xylene, chlorobenzene and bromobenzene, are the commonly found chemicals in pen inks. In this work, a dynamic headspace needle-trap device (D-HS-NTD) with a ZIF-8-derived nanoporous carbon (ZIF-8-NPC) as the adsorbent was developed for the extraction of some VOCs in different pen inks prior to GC-MS detection. The main important influencing experimental parameters including the flow rate of the purge gas N2, extraction temperature, extraction time, desorption temperature and desorption time for the extraction were optimized to obtain a high extraction efficiency...
July 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28734540/complete-avulsion-of-the-rotator-cuff-footprint-in-an-irreducible-traumatic-posterior-glenohumeral-fracture-dislocation-due-to-infraspinatus-interposition
#11
Ruben Scholten, Harm W Boons
No abstract text is available yet for this article.
August 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28734266/air-quality-and-health-effects-of-biogenic-volatile-organic-compounds-emissions-from-urban-green-spaces-and-the-mitigation-strategies
#12
Yuan Ren, Zelong Qu, Yuanyuan Du, Ronghua Xu, Danping Ma, Guofu Yang, Yan Shi, Xing Fan, Akira Tani, Peipei Guo, Ying Ge, Jie Chang
Biogenic volatile organic compounds (BVOCs) emissions lead to fine particulate matter (PM2.5) and ground-level ozone pollution, and are harmful to human health, especially in urban areas. However, most BVOCs estimations ignored the emissions from urban green spaces, causing inaccuracies in the understanding of regional BVOCs emissions and their environmental and health effects. In this study, we used the latest local vegetation datasets from our field survey and applied an estimation model to analyze the spatial-temporal patterns, air quality impacts, health damage and mitigating strategies of BVOCs emissions in the Greater Beijing Area...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734201/modification-of-chemical-properties-cu-fractionation-and-enzymatic-activities-in-an-acid-vineyard-soil-amended-with-winery-wastes-a-field-study
#13
Isabel Rodríguez-Salgado, Paula Pérez-Rodríguez, Antía Gómez-Armesto, Montserrat Díaz-Raviña, Juan Carlos Nóvoa-Muñoz, Manuel Arias-Estévez, David Fernández-Calviño
The effects of adding two winery wastes, perlite waste (PW) and bentonite waste (BW), to an acid vineyard soil were assessed using some chemical and biological soil properties in a field study that lasted 18 months. The addition of PW (up to 81 Mg ha(-1)) had neither significant nor permanent effects on soil characteristics such as the pH, organic matter content or nutrient concentrations, the amounts of copper or zinc, or the electrical conductivity. Moreover, no persistent negative effects were found on the enzymatic activities after PW application...
July 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28734200/rates-of-meaningful-change-in-the-mental-health-of-children-in-long-term-out-of-home-care-a-seven-to-nine-year-prospective-study
#14
Michael Tarren-Sweeney
Children residing in long-term out-of-home care have high rates of clinical-level mental health difficulties. However, the stability of these children's difficulties throughout their time in care is uncertain. This paper reports estimates of the seven- to nine-year stability of carer-reported scores on the Child Behavior Checklist (CBCL) and Assessment Checklists for Children (ACC) and Adolescents (ACA) for 85 children in long-term foster or kinship care. Prospective score changes on the CBCL total problems and ACC-ACA shared-item scales were assigned to one of four change groups: 'sustained mental health'; 'meaningful improvement'; 'no meaningful change'; and 'meaningful deterioration'...
July 19, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28734128/the-experience-of-initiating-injection-drug-use-and-its-social-context-a-qualitative-systematic-review-and-thematic-synthesis
#15
REVIEW
Andy Guise, Danielle Horyniak, Jason Melo, Ryan McNeill, Dan Werb
BACKGROUND AND AIM: Understanding the experience of initiating injection drug use and its social contexts is crucial to inform efforts to prevent transitions into this mode of drug consumption and support harm reduction. We systematically reviewed and synthesized existing qualitative scientific literature to identify the socio-structural contexts for, and experiences of, the initiation of injection drug use. METHODS: We systematically searched six databases (Medline, Embase, PsychINFO, CINAHL, IBSS, and SSCI), along with a manual search, including of key journals and subject experts...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28734111/adult-interest-in-using-a-hypothetical-modified-risk-tobacco-product-findings-from-wave-1-of-the-population-assessment-of-tobacco-and-health-study-2013-2014
#16
Jennifer L Pearson, Amanda L Johnson, Sarah E Johnson, Cassandra A Stanton, Andrea C Villanti, Raymond S Niaura, Allison M Glasser, Baoguang Wang, David B Abrams, K Michael Cummings, Andrew Hyland
BACKGROUND AND AIMS: The U.S. Family Smoking Prevention and Tobacco Control Act provides a pathway for manufacturers to market a modified risk tobacco product (MRTP). This study examines sociodemographic and tobacco use correlates of interest in a hypothetical MRTP in a nationally representative sample of U.S. adults. DESIGN: Cross sectional Wave 1 data from the 2013-2014 Population Assessment of Tobacco and Health (PATH) Study. SETTING: Household Audio-Computer Assisted Self-Interviews of U...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28734091/prediction-of-alcohol-use-disorder-using-personality-disorder-traits-a-twin-study
#17
Tom Rosenström, Fartein Ask Torvik, Eivind Ystrom, Nikolai Olavi Czajkowski, Nathan A Gillespie, Steven H Aggen, Robert F Krueger, Kenneth S Kendler, Ted Reichborn-Kjennerud
BACKGROUND AND AIMS: The DSM-IV Personality Disorders (PDs) are comorbid with Alcohol Use Disorder (AUD) and with each other. It remains unclear which PD criteria are most likely to drive onset and recurrence of AUD and which are merely confounded with those criteria. We determine which individual PD criteria predict AUD and the degree of underlying genetic and/or environmental etiology. DESIGN: A prospective observational twin study. SETTING: Norway 1999-2011...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28733845/genome-wide-identification-in-silico-characterization-and-expression-analysis-of-zip-like-genes-from-trichomonas-vaginalis-in-response-to-zinc-and-iron
#18
K G Fernández-Martín, M E Alvarez-Sánchez, V E Arana-Argáez, L C Alvarez-Sánchez, J C Lara-Riegos, J C Torres-Romero
Trace elements such as Zinc and Iron are essential components of metalloproteins and serve as cofactors or structural elements for enzymes involved in several important biological processes in almost all organisms. Because either excess or insufficient levels of Zn and Fe can be harmful for the cells, the homeostatic levels of these trace minerals must be tightly regulated. The Zinc regulated transporter, Iron regulated transporter-like Proteins (ZIP) comprise a diverse family, with several paralogues in diverse organisms and are considered essential for the Zn and Fe uptake and homeostasis...
July 21, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28733838/don-t-let-it-distract-you-how-information-about-the-availability-of-reward-affects-attentional-selection
#19
Michel Failing, Jan Theeuwes
Previous research has shown that attentional selection is affected by reward contingencies: previously selected and rewarded stimuli continue to capture attention even if the reward contingencies are no longer in place. In the current study, we investigated whether attentional selection also is affected by stimuli that merely signal the magnitude of reward available on a given trial but, crucially, have never had instrumental value. In a series of experiments, we show that a stimulus signaling high reward availability captures attention even when that stimulus is and was never physically salient or part of the task set, and selecting it is harmful for obtaining reward...
July 21, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28733818/occurrence-and-distribution-of-six-selected-endocrine-disrupting-compounds-in-surface-and-groundwaters-of-the-romagna-area-north-italy
#20
Emanuela Pignotti, Marinella Farré, Damià Barceló, Enrico Dinelli
Endocrine disrupting compounds (EDCs) are a wide group of contaminants of emerging concern known to be harmful for organisms. The aim of the study was to assess the occurrence and distribution of six EDCs (estrone-E1, ß-estradiol-E2, 17α-ethinylestradiol-EE2, bisphenol A-BPA, perfluooctanoic acid-PFOA, perfluorooctane sulfonate-PFOS) in the Apenninic rivers and groundwaters of the Romagna area (North of Italy). Groundwaters were unaffected by EDC contamination, while all classes of compounds were detected at concentrations above the method quantification limit (MQL) in the majority of the river bodies...
July 21, 2017: Environmental Science and Pollution Research International
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