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https://www.readbyqxmd.com/read/29169199/-internet-addiction-suicidality-and-non-suicidal-self-harming-behavior-a-systematic-review
#1
Toni Andreas Steinbüchel, Stephan Herpertz, Ina Külpmann, Aram Kehyayan, Jan Dieris-Hirche, Bert Theodor Te Wildt
Background Internet addiction (IA) is associated with a high rate of co-morbid mental disorders, especially depression, anxiety disorders, ADHD and personality disorders and a considerable level of psychological strain. In terms of risk assessment, the present work investigates the current research literature on suicidal behavior and non-suicidal self-injurious behavior (NSSI). Methods We performed a systematic literature search in 14 databases on title and abstract level for the most common keywords for IA, NSSI and suicidality...
November 23, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29169051/cyanobacteria-blooms-induce-embryonic-heart-failure-in-an-endangered-fish-species
#2
Jinmei Zi, Xiaofu Pan, Hugh J MacIsaac, Junxing Yang, Runbing Xu, Shanyuan Chen, Xuexiu Chang
Cyanobacterial blooms drive water-quality and aquatic-ecosystem deterioration in eutrophic lakes worldwide, mainly owing to their harmful, secondary metabolites. The response of fish exposed to these cyanobacterial chemicals, however, remains largely unknown. In this paper, we employed an endangered fish species (Sinocyclocheilus grahami) in Dianchi Lake, China to evaluate the risks of cell-free exudates (MaE) produced by a dominant cyanobacterium (Microcystis aeruginosa) on embryo development, as well as the molecular mechanisms responsible...
November 16, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29169013/body-mass-index-and-risk-of-dementia-analysis-of-individual-level-data-from-1-3-million-individuals
#3
Mika Kivimäki, Ritva Luukkonen, G David Batty, Jane E Ferrie, Jaana Pentti, Solja T Nyberg, Martin J Shipley, Lars Alfredsson, Eleonor I Fransson, Marcel Goldberg, Anders Knutsson, Markku Koskenvuo, Eeva Kuosma, Maria Nordin, Sakari B Suominen, Töres Theorell, Eero Vuoksimaa, Peter Westerholm, Hugo Westerlund, Maria Zins, Miia Kivipelto, Jussi Vahtera, Jaakko Kaprio, Archana Singh-Manoux, Markus Jokela
INTRODUCTION: Higher midlife body mass index (BMI) is suggested to increase the risk of dementia, but weight loss during the preclinical dementia phase may mask such effects. METHODS: We examined this hypothesis in 1,349,857 dementia-free participants from 39 cohort studies. BMI was assessed at baseline. Dementia was ascertained at follow-up using linkage to electronic health records (N = 6894). We assumed BMI is little affected by preclinical dementia when assessed decades before dementia onset and much affected when assessed nearer diagnosis...
November 20, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29168960/using-the-internet-to-access-health-related-information-results-from-a-nationally-representative-sample-of-new-zealand-secondary-school-students
#4
Jennifer Utter, Mathijs Lucassen, Simon Denny, Terry Fleming, Roshini Peiris-John, Terryann Clark
Objective To determine if secondary school students in New Zealand who report greater health concerns (e.g. significant depressive symptoms) are more likely to use the Internet to access health-related information. Methods A nationally representative health and wellbeing survey was undertaken in 2012 (n = 8500). Multiple regression models were used to examine the associations between students' use of the Internet to access health-related information and selected outcomes or indicators. Results Over 90% of students used the Internet on a daily basis, with 15...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168918/nano-biohybrids-in-vivo-synthesis-of-metal-organic-frameworks-inside-living-plants
#5
Joseph J Richardson, Kang Liang
Plants have a complex passive fluid transport system capable of internalizing small molecules from the environment, and this system offers an ideal route for augmenting plants with functional nanomaterials. Current plant augmentation techniques use pre-formed nanomaterials and permeabilizing agents or plant cuttings. A so far unexplored concept is the formation of the functional material, in situ, from precursors small enough to be passively internalized through the roots without harming the plants. Metal-organic frameworks are ideal for in situ synthesis as they are composed of metal ions coordinated with organic ligands and have recently been mineralized around single-celled organisms in mild aqueous conditions...
November 23, 2017: Small
https://www.readbyqxmd.com/read/29168862/inhibition-of-advanced-glycation-endproducts-during-fish-sausage-preparation-by-transglutaminase-and-chitosan-oligosaccharides-induced-enzymatic-glycosylation
#6
Jing Wang, Long Zou, Fangzhou Yuan, Liangtao Lv, Shenglan Tian, Zhenxing Li, Hong Lin
Advanced glycation endproducts (AGEs) are the harmful products of non-enzymatic reactions in foods formed during the heating process. In order to reduce the content of AGEs in foods, the inhibitory effect of different proportions of transglutaminase (TGase) and chitosan oligosaccharides (COS) on the AGEs of seabream fish meat sausage was studied. The results indicated that the TGase/COS ratio of 1 : 1 could inhibit the formation of AGEs, showing especially a decreased N(ε)-carboxymethyl-lysine (CML) content and a twice higher inhibition rate (36...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168788/microtubule-depolymerization-by-kinase-inhibitors-unexpected-findings-of-dual-inhibitors
#7
REVIEW
Kenji Tanabe
Microtubule-targeting agents are widely used as clinical drugs in the treatment of cancer. However, some kinase inhibitors can also disrupt microtubule organization by directly binding to tubulin. These unexpected effects may result in a plethora of harmful events and/or a misinterpretation of the experimental results. Thus, further studies are needed to understand these dual inhibitors. In this review, I discuss the roles of dual inhibitors of kinase activity and microtubule function as well as describe the properties underlining their dual roles...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168317/hepatitis-c-virus-prevalence-and-associated-risk-factors-among-indigenous-australians-who-inject-drugs
#8
Michael Doyle, Lisa Maher, Simon Graham, Handan Wand, Jenny Iversen
OBJECTIVE: To examine factors associated with hepatitis C virus (HCV) infection among a national sample of Indigenous and non-Indigenous people who inject drugs (PWID) in Australia. METHODS: Respondents were recruited from Australia's Needle Syringe Program Survey; an annual bio-behavioural surveillance project that monitors HCV antibody prevalence among PWID. Data from 2006-2015 were de-duplicated to retain only one record where individuals participated in >1 survey round...
November 22, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29168307/optimising-residential-respite-care-in-nursing-homes-current-problems-and-solutions-for-a-better-future
#9
Melissa Willoughby, Joseph Elias Ibrahim, Noha Ferrah, Lyndal Bugeja
AIM: To examine whether residential respite care increases the risk of harm to older people and suggest directions for future research and policy. BACKGROUND: Respite care is a vital part of the aged care system that supports dependent older people and their caregivers to continue residing in the community. There is little research determining whether an older person experiences harm from residential respite. METHODS: This commentary considered conceptual research and existing empirical evidence to determine whether the risk of death was greater during residential respite care for older people...
November 23, 2017: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/29168294/association-of-prenatal-folate-status-with-early-childhood-wheeze-and-atopic-dermatitis
#10
Aditi Roy, Mehmet Kocak, Terryl J Hartman, Shanda Vereen, Margaret Adgent, Chandrika Piyathilake, Frances A Tylavsky, Kecia N Carroll
BACKGROUND: Prenatal folic acid supplementation is recommended to prevent birth defects. Some foods are fortified in the U.S.to ensure sufficient intake among reproductive-aged women. However, high prenatal folate exposure may be a risk factor for childhood atopic diseases. We investigated associations between prenatal folate and early childhood wheeze and atopic dermatitis in a U.S. cohort. METHODS: We studied 858 mother-child dyads, enrolled prenatally. Folate was measured in 2(nd) and 3(rd) trimester maternal plasma...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29168290/gating-the-holes-in-the-swiss-cheese-part-i-expanding-professor-reason-s-model-for-patient-safety
#11
Shashi S Seshia, G Bryan Young, Michael Makhinson, Preston A Smith, Kent Stobart, Pat Croskerry
INTRODUCTION: Although patient safety has improved steadily, harm remains a substantial global challenge. Additionally, safety needs to be ensured not only in hospitals but also across the continuum of care. Better understanding of the complex cognitive factors influencing health care-related decisions and organizational cultures could lead to more rational approaches, and thereby to further improvement. HYPOTHESIS: A model integrating the concepts underlying Reason's Swiss cheese theory and the cognitive-affective biases plus cascade could advance the understanding of cognitive-affective processes that underlie decisions and organizational cultures across the continuum of care...
November 23, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29168262/cross-border-migration-and-initiation-of-others-into-drug-injecting-in-tijuana-mexico
#12
Claudia Rafful, Jason Melo, María Elena Medina-Mora, Gudelia Rangel, Xiaoying Sun, Sonia Jain, Dan Werb
INTRODUCTION AND AIMS: Efforts to prevent injection drug use (IDU) are increasingly focusing on the role that people who inject drugs (PWID) play in facilitating the entry of others into this behaviour. This is particularly relevant in settings experiencing high levels of IDU, such as Mexico's northern border region, where cross-border migration, particularly through forced deportation, has been found to increase a range of health and social harms related to injecting. DESIGN AND METHODS: PWID enrolled in a prospective cohort study in Tijuana, Mexico, since 2011 were interviewed semi-annually, which solicited responses on their experiences initiating others into injecting...
November 22, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29168256/alcohol-taxes-contribution-to-prices-in-high-and-middle-income-countries-data-from-the-international-alcohol-control-study
#13
Martin Wall, Sally Casswell, Sarah Callinan, Surasak Chaiyasong, Pham Viet Cuong, Gaile Gray-Phillip, Charles Parry
INTRODUCTION: Taxation is increasingly being used as an effective means of influencing behaviour in relation to harmful products. In this paper we use data from six participating countries of the International Alcohol Control Study to examine and evaluate their comparative prices and tax regimes. METHODS: We calculate taxes and prices for three high-income and three middle-income countries. The data are drawn from the International Alcohol Control survey and from the Alcohol Environment Protocol...
November 22, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29168129/flavone-protects-hbe-cells-from-dna-double-strand-breaks-caused-by-pm2-5
#14
Xing Ren, Yong Tang, Jiameng Sun, Jianbo Feng, Leilei Chen, Huixi Chen, Sijing Zeng, Changhui Chen, Xinqiu Li, Haixia Zhu, Zhaojun Zeng
Ambient air particulate matter 2.5 (PM2.5) contains many harmful components that can enter the circulatory system and produce reactive oxygen species (ROS) in body. Oxidative stress and DNA damage induced by ROS may affect any cellular macromolecule and lead to DNA double-strand breaks (DSBs). Flavonoids, widely distributed in some herbs and berries, have been proved having anti-oxidative or anti-cancer efficacy. In this study, we investigated whether Flavone, a kind of flavonoids, can protect human bronchial epithelial cells (HBE) from DSBs caused by PM2...
November 22, 2017: Human Cell
https://www.readbyqxmd.com/read/29168009/dietary-lipophilic-iron-accelerates-regional-brain-iron-load-in-c57bl6-mice
#15
Douglas G Peters, Carson J Purnell, Michael P Haaf, Qing X Yang, James R Connor, Mark D Meadowcroft
Impaired brain iron homeostatic mechanisms, independent of pathological hallmarks, are harmful to the brain because excess free iron can cause DNA, protein, and lipid damage via oxidative stress. The goal of this study was to evaluate the longitudinal effect of chronic iron overload and deficiency in the vertebrate brain. Ten-week-old C57BL6 male mice were randomly assigned to one of four unique dietary regiments for 1 year: iron-deficient, normal iron, and two different concentrations of lipophilic iron diet containing 3,5,5-trimethylhexanoyl ferrocene (TMHF)...
November 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29167651/nonsuicidal-self-injury-a-systematic-review
#16
Annarosa Cipriano, Stefania Cella, Paolo Cotrufo
Objective: Nonsuicidal self-injury (NSSI) refers to the intentional self-inflicted destruction of body tissue without suicidal intention and for purposes not socially sanctioned. Our paper presents an up-to-date overview on nonsuicidal, self-injurious behaviors. Method: In accordance with PRISMA guidelines, a systematic literature search was conducted across two databases, PubMed and PsycARTICLES, regarding the main features of NSSI with a focus on epidemiological and etiologic data, diagnostic criteria, and functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29167599/inhalable-dust-endotoxins-and-1-3-%C3%AE-d-glucans-as-indicators-of-exposure-in-waste-sorting-plant-environment
#17
Anna Kozajda, Karolina Jeżak, Marcin Cyprowski, Irena Szadkowska-Stańczyk
The aim of the study was to assess the levels of inhalable dust, endotoxins and (1-3)-β-d-glucans as agents harmful to the respiratory tract of workers of municipal waste sorting plants and interaction between these agents based on the measurements taken in two plants with different processing capacities. The study was conducted in summer season in two waste sorting plants (WSPs) differing in processing capacity. Samples of bioaerosol for inhalable dust (gravimetric method), endotoxins (LAL test in kinetic, chromogenic version) and (1-3)-β-d-glucans (Glucatell test in kinetic version) were collected from 42 sorting workers using individual aspirators with glass fiber filters during the work shift...
2017: Aerobiologia
https://www.readbyqxmd.com/read/29167228/contribution-of-impaired-parasympathetic-activity-to-right-ventricular-dysfunction-and-pulmonary-vascular-remodeling-in-pulmonary-arterial-hypertension
#18
Denielli da Silva Gonçalves Bos, Cathelijne E Van Der Bruggen, Kondababu Kurakula, Xiao-Qing Sun, Karina R Casali, Adenauer G Casali, Nina Rol, Robert Szulcek, Cris Dos Remedios, Christophe Guignabert, Ly Tu, Peter Dorfmuller, Marc Humbert, Paul J M Wijnker, Diederik W D Kuster, Jolanda van der Velden, Marie-José Goumans, Harm-Jan Bogaard, Anton Vonk-Noordegraaf, Frances S de Man, M Louis Handoko
Background -Beneficial effects of parasympathetic stimulation have been reported in left heart failure, however, whether it would be beneficial for pulmonary arterial hypertension (PAH) remains to be explored. Here, we investigated the relationship between parasympathetic activity and right ventricular (RV) function in PAH-patients, and the potential therapeutic effects of pyridostigmine (PYR), an oral drug stimulating the parasympathetic activity through acetylcholinesterase (AchE) inhibition, in experimental pulmonary hypertension (PH)...
November 22, 2017: Circulation
https://www.readbyqxmd.com/read/29167147/medication-errors-resulting-in-harm-using-chargemaster-data-to-determine-association-with-cost-of-hospitalization-and-length-of-stay
#19
Bryan C McCarthy, Kristin A Tuiskula, Tara P Driscoll, Andrew M Davis
PURPOSE: Results of an analysis of the economic impact of adverse drug events (ADEs) resulting in patient harm on hospitalization costs and length of stay (LOS) are reported. METHODS: In a retrospective single-site study, medication errors among patients admitted to an academic medical center during the period April 2014-May 2015 were identified using voluntary event reporting system data and diagnosis codes. Hospitalization cases involving documented ADEs resulting in harm, as defined on a widely used medication error classification index, were matched with control cases by admission period, diagnosis-related group, and patient age and sex...
December 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29167102/coffee-consumption-and-health-umbrella-review-of-meta-analyses-of-multiple-health-outcomes
#20
Robin Poole, Oliver J Kennedy, Paul Roderick, Jonathan A Fallowfield, Peter C Hayes, Julie Parkes
Objectives To evaluate the existing evidence for associations between coffee consumption and multiple health outcomes.Design Umbrella review of the evidence across meta-analyses of observational and interventional studies of coffee consumption and any health outcome.Data sources PubMed, Embase, CINAHL, Cochrane Database of Systematic Reviews, and screening of references.Eligibility criteria for selecting studies Meta-analyses of both observational and interventional studies that examined the associations between coffee consumption and any health outcome in any adult population in all countries and all settings...
November 22, 2017: BMJ: British Medical Journal
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