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Angle closure glaucoma

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https://www.readbyqxmd.com/read/28214354/long-chain-unsaturated-fatty-acids-as-possible-important-metabolites-for-primary-angle-closure-glaucoma-based-on-targeted-metabolomic-analysis
#1
Shengzhong Rong, Yang Li, Yue Guan, Lili Zhu, Qiang Zhou, Mucong Gao, Hongzhi Pan, Lina Zou, Dong Chang
Primary angle-closure glaucoma (PACG) is a severe chronic neurodegenerative disease in Asia. Identification of important metabolites associated with PACG is crucial for early intervention and advancing knowledge of the disease mechanism. We applied gas chromatography-mass spectrometry (GC-MS) for targeted metabolomic analysis on serum samples from thirty-eight newly diagnosed PACG patients and forty-eight controls. Palmitoleic acid (PA), linoleic acid (LA), gamma-linolenic acid (GLA) and arachidonic acid (ARA) were identified as important metabolites associated with PACG...
February 18, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28188405/success-rates-of-2-site-phacoemulsification-combined-with-fornix-based-trabeculectomy-using-mitomycin-c-for-primary-angle-closure-glaucoma-and-primary-open-angle-glaucoma-in-an-asian-population
#2
Victor Koh, David Chen, Cecilia Maria Aquino, Joel Aduan, Chelvin Sng, Loon Seng Chee, Paul Chew
PURPOSE: To determine the long-term outcomes of 2-site phacoemulsification combined with fornix-based trabeculectomy using mitomycin C (MMC) for primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) in an Asian population. METHODS: We reviewed the records of all patients with POAG or PACG who underwent phacoemulsification with trabeculectomy using MMC from January 2008 through December 2010 in a tertiary ophthalmology unit in Singapore. The primary outcome measure was cumulative success rates defined as complete [intraocular pressure (IOP) <21, 18, 15 mmHg without medication] and qualified (IOP <21, 18, 15 mmHg with at least 1 medication) success...
February 10, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28184333/pupillary-block-due-to-reverse-implantation-of-a-sulcus-intraocular-lens
#3
Xuemin Zhang, Nishant Soni, Janet Alexander, Sachin Kalarn, Osamah Saeedi
An 88-year-old woman with a history of complicated cataract extraction by phacoemulsification with sulcus intraocular lens (IOL) placement developed pseudophakic pupillary block after reverse implantation of the IOL. In the postoperative period, she had persistently elevated intraocular pressures (IOP) and was diagnosed with chronic angle-closure glaucoma that was treated medically. She presented 5 years later with acute pupillary block. The diagnosis of reverse IOL implantation was confirmed by ultrasound biomicroscopy...
August 2016: JCRS Online Case Reports
https://www.readbyqxmd.com/read/28168569/bilateral-acute-angle-closure-developing-due-to-use-of-ipratropium-bromide-and-salbutamol
#4
Mehmet Kola, Dilek Hacıoğlu, Hidayet Erdöl, Adem Türk
Acute angle closure can be seen as a side effect of some medications that can be used systemically. In this article, clinical characteristics of 54-year-old female patient who applied to our clinic with bilateral acute angle closure and has been received nebulized form of salbutamol and ipratropium bromide due to asthma for 4 days was evaluated. Right and left eye IOP were measured as 50 and 48 mmHg. IOP was reduced with anti-glaucomatous treatment. and peripheral iridectomy was done, and then the patient was discharged...
February 6, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28155692/fluid-and-structure-coupling-analysis-of-the-interaction-between-aqueous-humor-and-iris
#5
Wenjia Wang, Xiuqing Qian, Hongfang Song, Mindi Zhang, Zhicheng Liu
BACKGROUND: Glaucoma is the primary cause of irreversible blindness worldwide associated with high intraocular pressure (IOP). Elevated intraocular pressure will affect the normal aqueous humor outflow, resulting in deformation of iris. However, the deformation ability of iris is closely related to its material properties. Meanwhile, the passive deformation of the iris aggravates the pupillary block and angle closure. The nature of the interaction mechanism of iris deformation and aqueous humor fluid flow has not been fully understood and has been somewhat a controversial issue...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28154791/acute-angle-closure-glaucoma-secondary-to-polypoidal-choroidal-vasculopathy-a-devastating-complication
#6
Prabu Baskaran, Manavi D Sindal, Pankaja Dhoble, Seema Ramakrishnan, Venkatesh Rengaraj, Pradeep Ramulu
Acute angle closure glaucoma (ACG) in the setting of polypoidal choroidal vasculopathy (PCV) is a catastrophic complication that has been documented infrequently in literature. Ours is the second only report that describes hemorrhagic choroidal detachment as an event leading to acute angle closure glaucoma in PCV patients and the first one to describe the use of diode cyclophotocoagulation (CPC) for this condition. The purpose of this article is to familiarize readers with this entity that has an extremely dismal visual prognosis...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28153738/myocilin-expression-is-regulated-by-retinoic-acid-in-the-trabecular-meshwork-derived-cellular-environment
#7
Cécile Prat, Corinne Belville, Aurélie Comptour, Geoffroy Marceau, Gael Clairefond, Frédéric Chiambaretta, Vincent Sapin, Loïc Blanchon
Glaucoma is the leading cause of irreversible blindness and is usually classified as angle closure and open angle glaucoma (OAG). Primary open angle glaucoma represents the most frequent clinical presentation leading to ganglion cell death and optic nerve degeneration as a main consequence of an intraocular pressure' (IOP) increase. The mechanisms of this IOP increase in such pathology remain unclear but one protein called Myocilin could be a part of the puzzle in the trabecular meshwork (TM). Previously described to be transcriptionally regulated by glucocorticoids, the comprehension of the trabecular regulation of Myocilin' expression has only weakly progressed since 15 years...
January 30, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28149776/ex-press-implantation-with-phacoemulsification-in-poag-versus-cpacg
#8
Jie Lan, Da-Peng Sun, Jie Wu, Ya-Ni Wang, Li-Xin Xie
AIM: To compare the long-term outcomes of the Ex-PRESS miniature glaucoma device implanted under a scleral flap in combination of phacoemulsification with intraocular lens implantation in primary open angle glaucoma (POAG) and chronic primary angle-closure glaucoma (CPACG). METHODS: Retrospective, comparative study. A total of 60 eyes (60 patients) receiving the Ex-PRESS miniature glaucoma device implantation combined with phacoemulsification were reviewed. Thirty eyes (30 patients) had the combined procedures for POAG, and the other 30 eyes (30 patients) for CPACG...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28134964/association-of-plasma-complement-c3-levels-with-primary-angle-closure-glaucoma-in-older-women
#9
Shengjie Li, Yuhong Chen, Mingxi Shao, Li Tang, Xinghuai Sun, Wenjun Cao
Purpose: The plasma complement component (C)3 concentration and clinical characteristics of primary angle-closure glaucoma (PACG) subjects were analyzed to evaluate whether C3 levels were correlated with PACG severity. Methods: Peripheral blood samples from subjects with PACG (n = 237) and normal controls (n = 158) were collected. The plasma levels of C3 were measured by immunoturbidimetry. The assessments of intraocular pressure; vertical cup/disc ratio (VCDR); central corneal thickness; axial length; anterior chamber depth; visual field-derived mean deviation; and mean sensitivity were performed by glaucoma specialists...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28122025/intrinsic-functional-connectivity-alterations-of-the-primary-visual-cortex-in-primary-angle-closure-glaucoma-patients-before-and-after-surgery-a-resting-state-fmri-study
#10
Shenghong Li, Ping Li, Honghan Gong, Fei Jiang, Dan Liu, Fengqin Cai, Chonggang Pei, Fuqing Zhou, Xianjun Zeng
PURPOSE: To investigate the altered intrinsic functional connectivity (iFC) of the primary visual cortex (V1) in primary angle-closure glaucoma (PACG) patients before and after surgery using resting-state functional MRI. MATERIALS AND METHODS: Twenty-five preoperative PACG (pre-PACG) patients and 25 well-matched healthy controls (HCs) were included in this study, and 9 PACG patients were assessed again at least 3 months after treatment (post-PACG). We generated the iFC maps of the seed regions in the centers of the left and right V1 and conducted group comparisons...
2017: PloS One
https://www.readbyqxmd.com/read/28112134/intraocular-pressure-fluctuation-after-water-drinking-test-in-primary-angle-closure-glaucoma-and-primary-open-angle-glaucoma
#11
Yi-Chieh Poon, Mei-Ching Teng, Pei-Wen Lin, Jen-Chia Tsai, Ing-Chou Lai
CONTEXT: Only a few studies have assessed intraocular pressure (IOP) changes during the water drinking test (WDT) in patients with primary angle-closure glaucoma (PACG). AIMS: The aim of this study is to investigate IOP changes during WDT in patients with PACG versus primary open-angle glaucoma (POAG). SETTINGS AND DESIGN: This was a prospective and single tertiary center study. MATERIALS AND METHODS: PACG and POAG patients (n = 15 each) without prior glaucoma surgery were enrolled and subjected to WDT, wherein they consumed an amount of water proportional to their body weight within 10 min...
December 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28087548/early-lens-extraction-with-intraocular-lens-implantation-for-the-treatment-of-primary-angle-closure-glaucoma-an-economic-evaluation-based-on-data-from-the-eagle-trial
#12
Mehdi Javanbakht, Augusto Azuara-Blanco, Jennifer M Burr, Craig Ramsay, David Cooper, Claire Cochran, John Norrie, Graham Scotland
OBJECTIVE: To investigate the cost-effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma (PACG) compared to standard care. DESIGN: Cost-effectiveness analysis alongside a multicentre pragmatic two-arm randomised controlled trial. Patients were followed-up for 36 months, and data on health service usage and health state utility were collected and analysed within the trial time horizon. A Markov model was developed to extrapolate the results over a 5-year and 10-year time horizon...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28079654/retinal-oximetry-in-subjects-with-glaucomatous-hemifield-asymmetry
#13
Zhu Li Yap, Charles Ong, Yi Fang Lee, Andrew Tsai, Clarissa Cheng, Monisha E Nongpiur, Shamira A Perera
PURPOSE: Although some studies suggest a strong link between retinal vessel oxygenation and damage to the retinal nerve fiber layer (RNFL) seen in glaucoma, it has yet to be conclusively proven. This study compares intraocular retinal oximetry in glaucomatous eyes displaying asymmetrically affected hemifields across different subgroups of glaucoma, namely primary angle closure glaucoma (PACG), primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG). METHODS: In this prospective cross-sectional study, 99 patients (PACG, n=28; POAG, n=37; NTG, n=34) underwent retinal oxygenation and vessel caliber measurements using the Oxymap T1 Retinal Oximeter, Cirrus optical coherence tomography, and Humphrey visual field testing...
January 10, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28058167/isolated-microspherophakia-presenting-with-angle-closure-glaucoma
#14
Tülay Şimşek, Emrullah Beyazyıldız, Enver Şimşek, Faruk Öztürk
We report a case of 13-year-old girl presenting to our clinic with blurred vision in both eyes. Ophthalmic examination revealed high myopia and angle-closure glaucoma due to pupillary block caused by small, spherical crystalline lenses. Treatment approaches to glaucoma in patients with microspherophakia are discussed in this case report.
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28056057/flat-anterior-chamber-after-trabeculectomy-in-secondary-angle-closure-glaucoma-with-best1-gene-mutation-case-series
#15
Yimin Zhong, Xinxing Guo, Hui Xiao, Jingyi Luo, Chengguo Zuo, Xiaobo Huang, Jingjing Huang, Lan Mi, Qingjiong Zhang, Xing Liu
PURPOSE: Trabeculectomy has been regarded as a mainstay of initial treatment in eyes of angle closure glaucoma (ACG) with peripheral anterior synechia > 180° in the Chinese population while its efficacy in secondary ACG with BEST1 gene mutation remains unclear. We set out to investigate the treatment outcome of trabeculectomy for secondary ACG in a group of patients with autosomal recessive bestrophinopathy (ARB). METHODS: In this retrospective case series study, 8 secondary ACG patients with ARB and their 4 recruited family members underwent a thorough ophthalmic examination including best-corrected visual acuity, Goldmann applanation tonometry, gonioscopy, and fundus examinations...
2017: PloS One
https://www.readbyqxmd.com/read/28039061/primary-angle-closure-glaucoma-what-we-know-and-what-we-don-t-know
#16
REVIEW
Xinghuai Sun, Yi Dai, Yuhong Chen, Dao-Yi Yu, Stephen J Cringle, Junyi Chen, Xiangmei Kong, Xiaolei Wang, Chunhui Jiang
Primary angle-closure glaucoma (PACG) is a common cause of blindness. Angle closure is a fundamental pathologic process in PAGC. With the development of imaging devices for the anterior segment of the eye, a better understanding of the pathogenesis of angle closure has been reached. Aside from pupillary block and plateau iris, multiple-mechanisms are more common contributors for closure of the angle such as choroidal thickness and uveal expansion, which may be responsible for the presenting features of PACG...
December 28, 2016: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28035845/efficacy-of-nd-yag-laser-iridotomies-in-primary-angle-closure-diseases-superior-peripheral-iridotomy-versus-inferior-peripheral-iridotomy
#17
Mostafa Ahmadi, Zahra Naderi Beni, Afsaneh Naderi Beni, Farzan Kianersi
PURPOSE: To evaluate the efficacy and safety of superior peripheral iridotomy versus inferior peripheral iridotomy in the treatment of primary angle closure glaucoma (PACG) in phakic patients. METHODS: In this randomized, prospective, paired-eye comparative study, patients with primary angle closure or primary angle-closure suspects were recruited and randomized to receive (NdYAG) laser peripheral iridotomy (LPI) superiorly in one eye and inferiorly in the other eye...
December 30, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28001106/evaluation-of-potential-risk-factors-for-development-of-primary-angle-closure-glaucoma-in-bouviers-des-flandres
#18
Alexis J Dubin, Ellison Bentley, Kevin A Buhr, Paul E Miller
OBJECTIVE To evaluate potential risk factors for development of primary angle-closure glaucoma (PACG) in Bouviers des Flandres. DESIGN Prospective, observational study. ANIMALS 98 Bouviers des Flandres. PROCEDURES All dogs underwent slit-lamp biomicroscopy, indirect ophthalmoscopy, gonioscopy, applanation tonometry, streak retinoscopy, and A-scan, B-scan, and high-resolution ultrasonography. Iridocorneal angles and degree of pectinate ligament dysplasia sheeting were graded, and an angle index was mathematically derived for each eye on the basis of these values...
January 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27990116/combined-acute-haemolytic-and-secondary-angle-closure-glaucoma-following-spontaneous-intraocular-haemorrhages-in-a-patient-on-warfarin
#19
Walter Andreatta, Stavroula Boukouvala, Atul Bansal
BACKGROUND: To report the first described case of combined haemolytic and acute angle closure glaucoma secondary to spontaneous intraocular haemorrhages in a patient on excessive anticoagulation. To the best of our knowledge, this is the first case reported in the literature presenting with raised intraocular pressure due to both mechanisms. CASE DESCRIPTION: A 90-year-old woman presented with acute pain and reduction in vision in the left eye. Her intraocular pressure (IOP) was 55 mm Hg...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27982217/bilateral-acute-angle-closure-glaucoma-as-a-first-presentation-of-granulomatosis-with-polyangiitis-wegener-s
#20
Alper Mete, Sabit Kimyon, Oguzhan Saygili, Can Pamukcu, Kıvanç Güngör
We report a case of bilateral acute angle-closure glaucoma in a patient with undiagnosed granulomatosis with polyangiitis (Wegener's). A 59-year-old man presented with a severe headache, ocular pain, blurred vision, shortness of breath, and mild fever. Clinical examination revealed conjunctival chemosis, corneal edema, and shallow anterior chambers. Closed angles were observed bilaterally on gonioscopy. The patient was treated with intravenous mannitol, oral acetazolamide, and anti-glaucomatous eye drops. Over the following two days, his vision improved and intraocular pressures decreased...
September 2016: Arquivos Brasileiros de Oftalmologia
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