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Q-M Wu, Y-N Guo, Y-Q Xu
OBJECTIVE: This aim of this study is to investigate the diagnostic performance of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in pancreatic lesions. PATIENTS AND METHODS: Patients with pancreatic lesions after CT (or MRI) and EUS-FNA examination were retrospectively enrolled. Cytopathological diagnosis of pancreas tissue were obtained by surgery or EUS-FNA. Clinical follow-up results were used as golden standard for diagnosis of pancreatic lesions...
March 2018: European Review for Medical and Pharmacological Sciences
W Huajun, F Ying, Z Hongxing, S Weifeng, S Pingyang, H Mingde, L Guoguang
OBJECTIVE: To analyze the clinical value of combined detection of serum APE1-Aabs and CEACAM-1 in pathological diagnosis of colorectal cancer. PATIENTS AND METHODS: From December 2014 to July 2016, 60 patients with colorectal cancer and 50 healthy subjects were enrolled in this study. The levels of APE1-AAbs, CEACAM-1 and CEA in the serum were measured, and the clinical value of each index in the diagnosis of colorectal cancer was analyzed. RESULTS: The level of serum APE1-AAbs in colorectal cancer group was significantly higher than that in healthy control group (p < 0...
March 2018: European Review for Medical and Pharmacological Sciences
Chao-Ching Ho, Dung-Sheng Wu
Spark-assisted chemical engraving (SACE) is a non-traditional machining technology that is used to machine electrically non-conducting materials including glass, ceramics, and quartz. The processing accuracy, machining efficiency, and reproducibility are the key factors in the SACE process. In the present study, a machine vision method is applied to monitor and estimate the status of a SACE-drilled hole in quartz glass. During the machining of quartz glass, the spring-fed tool electrode was pre-pressured on the quartz glass surface to feed the electrode that was in contact with the machining surface of the quartz glass...
March 22, 2018: Materials
Kexin Wang, Xiang Wen, Dibo Hou, Dezhan Tu, Naifu Zhu, Pingjie Huang, Guangxin Zhang, Hongjian Zhang
In water-quality, early warning systems and qualitative detection of contaminants are always challenging. There are a number of parameters that need to be measured which are not entirely linearly related to pollutant concentrations. Besides the complex correlations between variable water parameters that need to be analyzed also impairs the accuracy of quantitative detection. In aspects of these problems, the application of least-squares support vector machines (LS-SVM) is used to evaluate the water contamination and various conventional water quality sensors quantitatively...
March 22, 2018: Sensors
HyunGi Cho, Suyong Yeon, Hyunga Choi, Nakju Doh
In a group of general geometric primitives, plane-based features are widely used for indoor localization because of their robustness against noises. However, a lack of linearly independent planes may lead to a non-trivial estimation. This in return can cause a degenerate state from which all states cannot be estimated. To solve this problem, this paper first proposed a degeneracy detection method. A compensation method that could fix orientations by projecting an inertial measurement unit's (IMU) information was then explained...
March 22, 2018: Sensors
Dario de Biase, Michela Visani, Giorgia Acquaviva, Adele Fornelli, Michele Masetti, Carlo Fabbri, Annalisa Pession, Giovanni Tallini
CONTEXT: - Integration of the analysis of genetic markers with endoscopic ultrasound-guided fine-needle aspiration and cytologic evaluation has increased the accuracy of the preoperative diagnosis of pancreatic lesions. The application of high-throughput gene panel analysis using next-generation sequencing platforms is now offering a great opportunity for further improvements. OBJECTIVE: - To review the application of next-generation sequencing to the preoperative diagnosis of pancreatic lesions...
April 2018: Archives of Pathology & Laboratory Medicine
Clara Helena González-Correa, Julio César Caicedo-Eraso
BACKGROUND: The accuracy and precision of the BIA method is affected by the electrode system. Failing to adjust for differences in it may result in systematic biases of up to 5.2%. METHODS: Forty females ranging from 18 to 24 years, with a body mass index (BMI) of 18.6 to 27.6 kg/m2, were measured by BIA in the frequency range 5 to 500 kHz using the manufacturers recommended electrodes and two types of commercial ECG electrodes (3M-2228 and 3M-2330). RESULTS: The two types of ECG electrodes performed well, but at high frequencies 2330 performed better...
January 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Elise Cornelis, Ellen Gorus, Karen Van Weverbergh, Ingo Beyer, Patricia De Vriendt
BACKGROUND: Several methods have been developed to evaluate activities of daily living (ADLs) in mild cognitive impairment (MCI) and mild dementia. This study evaluated the convergent and concurrent validity between (1) two report-based methods (the advanced (a)- and instrumental (i)-ADL tools) and (2) a performance-based method (the Naturalistic Action Test (NAT)) to check if their ability to differentiate between cognitively healthy comparisons (HCs), persons with MCI, and persons with mild Alzheimer's disease (AD) are comparable to each other...
March 22, 2018: International Psychogeriatrics
Numan Cim, Harun Egemen Tolunay, Baris Boza, Harun Arslan, Can Ates, İbrahim İlik, Fatih Mehmet Tezcan, Recep Yıldızhan, Hanım Guler Sahin, Alpaslan Yavuz
We aimed to evaluate the efficiency of placental elasticity in predicting a placental invasion anomaly with the Virtual Touch Quantification (VTQ) technique. Pregnant women in the third trimester with suspected placental invasion anomaly were enrolled into the research (n = 58). The placenta was evaluated and divided into three equal parts as foetal edge (inner 1/3 of placenta), maternal edge (outer 1/3 of placenta) and the central part (central 1/3 of placenta). Shear wave velocity (SWV) measurements were used in the elastographic evaluation of placentas by VTQ...
March 22, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Thomas Desmond, Patricia Arthur, Kathleen Watt
PURPOSE: There is currently little evidence assessing the repeatability and accuracy of central corneal thickness measurements using the devices Tonoref III and RS-3000. This study aims to compare these devices against measurements by ultrasound pachymetry. METHODS: Central corneal thicknesses were measured on 50 eyes. Measurements from two non-contact devices-Tonoref III (NIDEK CO., LTD, Gamagori, Japan) and RS-3000 (NIDEK CO., LTD, Gamagori, Japan)-were compared against ultrasound pachymetry, the gold standard...
March 21, 2018: International Ophthalmology
Yuichi Nomura, Yoshitaka Asano, Jun Shinoda, Hirohito Yano, Yuka Ikegame, Tomohiro Kawasaki, Noriyuki Nakayama, Takashi Maruyama, Yoshihiro Muragaki, Toru Iwama
PURPOSE: The aim of this study was to assess whether dynamic PET with11 C-methionine (MET) (MET-PET) is useful in the diagnosis of brain tumors. METHODS: One hundred sixty patients with brain tumors (139 gliomas, 9 meningiomas, 4 hemangioblastomas and 8 primary central nervous system lymphomas [PCNSL]) underwent dynamic MET-PET with a 3-dimensional acquisition mode, and the maximum tumor MET-standardized uptake value (MET-SUV) was measured consecutively to construct a time-activity curve (TAC)...
March 21, 2018: Journal of Neuro-oncology
Guan-Min Quan, Yong-Li Zheng, Tao Yuan, Jian-Ming Lei
To evaluate the prognostic value of fluid-attenuated inversion recovery (FLAIR) signal intensity of postoperative cavity on progression free survival (PFS) and overall survival (OS) in patients with high-grade gliomas (HGG). This study retrospectively enrolled 45 consecutive HGG patients. These patients had chemoradiotherapy after gross-total resection of tumors. Quantitative analysis of the FLAIR signal intensity in postoperative cavity and background was made. We evaluated the threshold value, accuracy, sensitivity, specificity, and survival state with this technique...
March 21, 2018: Journal of Neuro-oncology
James Deraeve, William H Alexander
Multi-voxel pattern analysis often necessitates feature selection due to the high dimensional nature of neuroimaging data. In this context, feature selection techniques serve the dual purpose of potentially increasing classification accuracy and revealing sets of features that best discriminate between classes. However, feature selection techniques in current, widespread use in the literature suffer from a number of deficits, including the need for extended computational time, lack of consistency in selecting features relevant to classification, and only marginal increases in classifier accuracy...
March 21, 2018: Neuroinformatics
Alessandra Biancolillo, Silvia De Luca, Sebastian Bassi, Léa Roudier, Remo Bucci, Andrea D Magrì, Federico Marini
Common hazelnuts are widely present in human diet all over the world, and their beneficial effects on the health have been extensively investigated and demonstrated. Different in-depth researches have highlighted that the harvesting area can define small variations in the chemical composition of the fruits, affecting their quality. As a consequence, it has become relevant to develop methodologies which would allow authenticating and tracing hazelnuts. In the light of this, the present work aims to develop a non-destructive method for the authentication of a specific high-quality Italian hazelnut, "Nocciola Romana," registered with a protected designation of origin (PDO)...
March 21, 2018: Environmental Science and Pollution Research International
A Dehmoobad Sharifabadi, D A Korevaar, T A McGrath, N van Es, R A Frank, L Cherpak, W Dang, J P Salameh, F Nguyen, C Stanley, M D F McInnes
OBJECTIVES: The objective of this study was to evaluate whether higher reported accuracy estimates are associated with shorter time to publication among imaging diagnostic accuracy studies. METHODS: We included primary imaging diagnostic accuracy studies, included in meta-analyses from systematic reviews published in 2015. For each primary study, we extracted accuracy estimates, participant recruitment periods and publication dates. Our primary outcome was the association between Youden's index (sensitivity + specificity - 1, a single measure of diagnostic accuracy) and time to publication...
March 21, 2018: European Radiology
Zhi-Cheng Li, Hongmin Bai, Qiuchang Sun, Qihua Li, Lei Liu, Yan Zou, Yinsheng Chen, Chaofeng Liang, Hairong Zheng
OBJECTIVES: To build a reliable radiomics model from multiregional and multiparametric magnetic resonance imaging (MRI) for pretreatment prediction of O6 -methylguanine-DNA methyltransferase (MGMT) promotor methylation status in glioblastoma multiforme (GBM). METHODS: In this retrospective multicentre study, 1,705 multiregional radiomics features were automatically extracted from multiparametric MRI. A radiomics model with a minimal set of all-relevant features and a radiomics model with univariately-predictive and non-redundant features were built for MGMT methylation prediction from a primary cohort (133 patients) and tested on an independent validation cohort (60 patients)...
March 21, 2018: European Radiology
Yu Ohkura, Junichi Shindoh, Masaki Ueno, Toshiro Iizuka, Harushi Udagawa
BACKGROUND: Treatment for patients who have achieved clinical complete response (cCR) after neoadjuvant therapy has not been established, and there is no consensus regarding the indications for either esophagectomy or nonsurgical treatment. METHODS: Among 1,545 patients with esophageal cancer at Toranomon Hospital between January 2006 and August 2017, 39 who achieved cCR after neoadjuvant treatment were divided into two groups according to treatment: esophagectomy group (n = 18) and nonsurgical treatment group (n = 21) for comparison...
March 21, 2018: Annals of Surgical Oncology
Hyun Jung Koo, Joon-Won Kang, Jeong A Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee, Tae-Hwan Lim, Dong Hyun Yang
In patients with aortic regurgitation (AR), a precise preoperative assessment of aortic valve (AV) pathology is important if AV repair or sparing operation is an alternative option. The aim of this study was to assess the diagnostic accuracy of computed tomography (CT) for evaluating the AR mechanism compared with surgical inspection. 59 patients with AR who underwent AV surgery and preoperative cardiac CT were evaluated. AR mechanism was classified into type 1 (aortic dilatation or cusp perforation), type 2 (prolapsed cusp) and type 3 (cusp retraction)...
March 21, 2018: International Journal of Cardiovascular Imaging
Yaxia Yuan, Fang Zheng, Chang-Guo Zhan
Blood-brain barrier (BBB) permeability of a compound determines whether the compound can effectively enter the brain. It is an essential property which must be accounted for in drug discovery with a target in the brain. Several computational methods have been used to predict the BBB permeability. In particular, support vector machine (SVM), which is a kernel-based machine learning method, has been used popularly in this field. For SVM training and prediction, the compounds are characterized by molecular descriptors...
March 21, 2018: AAPS Journal
U Hassan, R Zhu, R Bashir
Sepsis, as a leading cause of death worldwide, relies on systemic inflammatory response syndrome (SIRS) criteria for its diagnosis. SIRS is highly non-specific as it relies on monitoring of patients' vitals for sepsis diagnosis, which are known to change with many confounding factors. Changes in leukocyte counts and CD64 expression levels are known specific biomarkers of pro-inflammatory host response at the onset of sepsis. Recently, we have developed a biosensor chip that can enumerate the leukocyte counts and quantify the neutrophil CD64 expression levels from a drop of blood...
March 22, 2018: Lab on a Chip
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