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https://www.readbyqxmd.com/read/28108299/mouse-model-of-hydroquinone-hypersensitivity-via-innate-and-acquired-immunity-and-its-promotion-by-combined-reagents
#1
Kanan Bando, Yukinori Tanaka, Toshinobu Kuroishi, Keiichi Sasaki, Teruko Takano-Yamamoto, Shunji Sugawara, Yasuo Endo
We established a mouse model of contact hypersensitivity (CHS) to hydroquinone (HQ), a widespread chemical in our environment. HQ was painted onto flanks. Then, HQ was challenged by painting onto ear-pinnas on days 7 and 14. The CHS after the 2(nd) challenge was markedly greater than that after the 1(st) challenge. Both challenges increased thymic stromal lymphopoietin (TSLP) and Th2 cytokines in ear-pinnas, while IFN-γ (typical Th1 cytokine) was decreased, despite an increase in IL-18 (typical IFN-γ inducer)...
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28106291/ocular-effects-of-sulfur-mustard-and-therapeutic-approaches-a-review
#2
Yunes Panahi, Seyyed Mahdi Rajaee, Amirhossein Sahebkar
Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28095562/the-efficacy-of-q-switched-nd-yag-1064-nm-laser-in-recalcitrant-macular-amyloidosis-a-case-report
#3
Nevil Khurana, Christine Urman
Macular amyloidosis typically presents as small, dusky-brown or greyish pigmented macules, the result of altered keratin deposition. Treatment of these hyperpigmented regions with topical and systemic therapies remains challenging, however Q-Switched neodymi- um-doped yttrium aluminum garnet (ND:YAG) laser has proven to be an effective treatment modality to reduce hyperpigmentation. In this case report we investigated the ef cacy of Q-Switched Nd:YAG laser treatment on a 34-year old woman with recalcitrant macular amyloidosis who failed to respond to over-the-counter bleaching creams...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28088997/predictors-of-actinic-keratosis-count-in-patients-with-multiple-keratinocyte-carcinomas-a-cross-sectional-study
#4
Julia A Siegel, Adam J Luber, Martin A Weinstock
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28070082/evaluation-of-structural-isomers-molecular-interactions-reactivity-descriptors-and-vibrational-analysis-of-tretinoin
#5
T Karthick, Poonam Tandon, Swapnil Singh
Tretinoin is known to be a pharmaceutical drug for treating acne vulgaris, keratosis pilaris, and acute promyelocytic leukemia. In order to reveal the possible conformers of tretinoin, the energies of all the conformers through rotational bonds have been evaluated by systematic rotor search analysis. The intramolecular interactions ranging from strong hydrogen bonds to weak van der Waals forces present in tretinoin have been distinguished with the help of electron density mapping and wavefunction analysis. The global reactivity descriptors and Fukui functions of tretinoin have been calculated and discussed...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28052368/synthesis-and-activity-of-the-salicylic-acid-ester-of-bakuchiol-in-psoriasis-surrogate-keratinocytes-and-skin-substitutes
#6
S Ma, K Gobis, W R Swindell, R Chaudhuri, R Bojanowski, K Bojanowski
BACKGROUND: Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient compliance. Development of retinoid analogues with minimal AEs would allow a broader and more compliant use. AIM: To synthesise a novel molecule, bakuchiol salicylate (bakusylan), with a modulatory gene expression profile similar to retinoids, using as reference three prescription retinoids: tretinoin, tazarotene and adapalene...
January 4, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28024127/combined-therapy-in-vulvar-lichen-sclerosus-does-topical-tretinoin-improve-the-efficacy-of-mometasone-furoate
#7
Alessandro Borghi, Sara Minghetti, Giulia Toni, Annarosa Virgili, Monica Corazza
Purpose To assess efficacy and safety profile of combining a potent corticosteroid with a retinoid in in the treatment of vulvar lichen sclerosus (VLS). Methods We retrospectively compared 21 VLS patients treated with tretinoin (T) in short contact therapy and mometasone furoate (MMF) (group A) and 20 treated with cold cream (CC) and MMF (group B) for 5 consecutive days/week for 12 weeks. The efficacy parameters were the response rate, the percentage of patients achieving an improvement from baseline of ≥75% in subjective and objective scores, and the mean reduction in subjective and objective scores...
December 26, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27999648/comparison-of-long-pulsed-alexandrite-laser-and-topical-tretinoin-ammonium-lactate-in-axillary-acanthosis-nigricans-a-case-series-of-patients-in-a-before-after-trial
#8
Amirhoushang Ehsani, Pedram Noormohammadpour, Azadeh Goodarzi, Mostafa Mirshams Shahshahani, Seyede Pardis Hejazi, Elhamsadat Hosseini, Arghavan Azizpour
BACKGROUND: Acanthosis nigricans (AN) is a brown to black, velvety hyperpigmentation of the skin that usually involves cutaneous folds. Treatment of AN is important regarding cosmetic reasons and various therapeutic modalities have been used for these purposes. The goal of this study was to compare the effectiveness of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate for treatment of axillary-AN. METHODS: Fifteen patients with bilateral axillary-AN were studied in Razi Hospital, Tehran, Iran...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27984170/autism-genes-are-selectively-targeted-by-environmental-pollutants-including-pesticides-heavy-metals-bisphenol-a-phthalates-and-many-others-in-food-cosmetics-or-household-products
#9
REVIEW
C J Carter, R A Blizard
The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG's) from the Autworks database to interrogate ∼1 million chemical/gene interactions in the comparative toxicogenomics database. Any bias towards ASG's was statistically determined for each chemical. Many suspect compounds identified in epidemiology, including tetrachlorodibenzodioxin, pesticides, particulate matter, benzo(a)pyrene, heavy metals, valproate, acetaminophen, SSRI's, cocaine, bisphenol A, phthalates, polyhalogenated biphenyls, flame retardants, diesel constituents, terbutaline and oxytocin, inter alia showed a significant degree of bias towards ASG's, as did relevant endogenous agents (retinoids, sex steroids, thyroxine, melatonin, folate, dopamine, serotonin)...
October 27, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27976510/evaluation-of-salicylic-acid-peeling-in-comparison-with-topical-tretinoin-in-the-treatment-of-postinflammatory-hyperpigmentation
#10
Basma Morad Mohamed Ali, Shereen Farouk Gheida, Nageh Ahmed El Mahdy, Shery Nashaat Sadek
BACKGROUND: Postinflammatory hyperpigmentation (PIH) is an acquired hyperpigmentation that involves areas of prior cutaneous inflammation. In addition to prevention, there are a variety of medications and procedures used to treat PIH. AIM OF THE WORK: The aim of this work was to evaluate the efficacy, tolerability, and safety of salicylic acid peeling in comparison with topical tretinoin in the treatment of PIH. PATIENTS AND METHODS: This study included forty-five patients with PIH lesions...
December 15, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27886445/beard-hair-density-increase-a-possible-role-of-topical-tretinoin-application
#11
Michelangelo Vestita, Giuseppe Giudice, Domenico Bonamonte, Doriana Apruzzi, Angela Filoni
No abstract text is available yet for this article.
November 25, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27761082/retinoids-literature-review-and-suggested-algorithm-for-use-prior-to-facial-resurfacing-procedures
#12
Patrick J Buchanan, Robert H Gilman
Vitamin A-containing products have been used topically since the early 1940s to treat various skin conditions. To date, there are four generations of retinoids, a family of Vitamin A-containing compounds. Tretinoin, all-trans-retinoic acid, is a first-generation, naturally occurring, retinoid. It is available, commercially, as a gel or cream. The authors conducted a complete review of all studies, clinical- and basic science-based studies, within the literature involving tretinoin treatment recommendations for impending facial procedures...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27746652/a-prospective-split-face-comparative-study-of-periorbital-wrinkle-treatments-fractional-erbium-doped-yttrium-aluminum-garnet-laser-intense-pulsed-light-and-topical-0-1-tretinoin-cream
#13
So Eun Park, Sang Seok Kim, Chul Woo Kim, Young Her
No abstract text is available yet for this article.
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27698500/arsenic-trioxide-and-tretinoin-aso-atra-for-acute-promyelocytic-leukemia-apl
#14
Erin Damery, Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr., President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
September 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27598619/are-topical-retinoids-teratogenic
#15
Stefano Veraldi, Luisa C Rossi, Mauro Barbareschi
Retinoic acid is a physiological compound of human blood. Blood levels range from 1000 to 7000 pg/mL (usually 1500-5000 pg/mL). Results of studies on absorption of topical retinoic acid in laboratory animals, although rather conflicting, demonstrate that it induces plasma concentrations which are well below concentrations caused by non-teratogenic oral doses. In humans, minimal percutaneous absorption of tretinoin was observed after topical applications. Neither single dose nor long-term treatment with topical tretinoin affect the endogenous levels of retinoic acid or its metabolites...
December 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27559498/misuse-of-topical-corticosteroids-on-the-face-a-cross-sectional-study-among-dermatology-outpatients
#16
Abhijeet Kumar Jha, Rajesh Sinha, Smita Prasad
BACKGROUND: Topical corticosteroids (TC) are being misused widely on the face without a prescription from the dermatologist. AIM: To evaluate the misuse of TC-containing preparations on the face and the adverse effects due to its application. MATERIALS AND METHODS: A questionnaire-based analysis was done among patients attending the dermatology outpatient department of a tertiary care hospital between March 2014 and March 2015. Patients with various facial dermatoses were asked about their current use of topical preparations and on further followup questioning, those who revealed the use of TCs (25g or more) continuously or intermittently for a minimum duration of four weeks were included in the study and observed for local adverse effects...
July 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27524916/ability-of-sodium-copper-chlorophyllin-complex-to-repair-photoaged-skin-by-stimulation-of-biomarkers-in-human-extracellular-matrix
#17
John P McCook, Thomas J Stephens, Lily I Jiang, Robert M Law, Vincent Gotz
PURPOSE: To examine the effect of sodium copper chlorophyllin complex on the expression of biomarkers of photoaged dermal extracellular matrix indicative of skin repair. PATIENTS AND METHODS: Following a previously published 12-day clinical assessment model, skin biopsy samples from the forearms of four healthy females with signs of photoaged skin were obtained and samples were analyzed by immunohistochemistry for key biomarkers of aging skin after each subject was treated with a test material consisting of a gel containing a liposomal dispersion of sodium copper chlorophyllin complex 0...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27519827/nanostructured-lipid-carriers-for-the-topical-delivery-of-tretinoin
#18
Vivek M Ghate, Shaila A Lewis, Prabhakara Prabhu, Akhilesh Dubey, Nilkumar Patel
Cosmetic skin care products currently in the market demonstrate an increasing trend toward antiaging products. Selection of the right formulation approach is the key to successful consumer acceptance. Nanostructured lipid carriers (NLCs) for dermal application can render added benefits to the formulation. Tretinoin a derivative of vitamin A, is a retinoid with anti-aging and anti-acne potential. The present study was aimed at formulating NLCs of tretinoin for reducing the skin irritation potential, increasing the drug loading capacity and prolonging the duration of action...
November 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27504543/efficacy-of-trichloro-acetic-acid-peel-alone-versus-combined-topical-magnesium-ascorbyl-phosphate-for-epidermal-melasma
#19
Fatima Murtaza, Abdur Rahim Bangash, Arshad Khushdil, Sahibzada Mahmood Noor
OBJECTIVE: To compare the efficacy in terms of reduction in melasma area and severity index (MASI) score by more than 10 of a combination of 20% trichloro-acetic acid peel plus 5% topical magnesium ascorbyl phosphate versus 20% trichloroacetic acid peel alone in the treatment of epidermal melasma. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Department of Dermatology, Lady Reading Hospital (LRH), Peshawar, from May 2012 to May 2013...
July 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27502087/bilateral-nevus-comedonicus-of-the-eyelids-associated-with-bladder-cancer-and-successful-treatment-with-topical-tretinoin
#20
Mualla Polat, Bengu Altunay Tuman, Asli Sahin, Umit Dogan, Cetin Boran
No abstract text is available yet for this article.
November 2016: Dermatologic Therapy
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