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https://www.readbyqxmd.com/read/28398420/clindamycin-phosphate-tretinoin-combination-gel-revisited-status-report-on-a-specific-formulation-used-for-acne-treatment
#1
James Q Del Rosso
Topical agents, including retinoids and antibiotics, are commonly used to treat acne vulgaris (AV) and remain as components of acne treatment guidelines. Approved topical combination formulations offer the advantages of established efficacy, decreased frequency of application, and improved convenience for patients. This article discusses both clindamycin phosphate (CP) and tretinoin (Tret) as components of a topical aqueous-based combination gel that has been shown to be effective, safe, and well tolerated for treatment of facial AV...
March 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28293257/the-effectiveness-of-a-5-retinoic-acid-peel-combined-with-microdermabrasion-for-facial-photoaging-a-randomized-double-blind-placebo-controlled-clinical-trial
#2
Gita Faghihi, Saghi Fatemi-Tabaei, Bahareh Abtahi-Naeini, Amir Hossein Siadat, Giti Sadeghian, Mohammad Ali Nilforoushzadeh, Hamed Mohamadian-Shoeili
Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods. Forty-five patients, aged 35-70, affected by moderate-to-severe photodamage were enrolled in this trial. All patients received 3 sessions of full facial microdermabrasion and 3 sessions of either 5% retinoic acid peel or placebo after the microdermabrasion. Efficacy was measured using the Glogau scale...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28274863/microfluidic-aided-fabrication-of-nanoparticles-blend-based-on-chitosan-for-a-transdermal-multidrug-delivery-application
#3
Mohammad Shamsi, Payam Zahedi, Hedayatollah Ghourchian, Sara Minaeian
The aim of this work was to provide a microfluidic-aided fabrication of nanoparticles based on chitosan/poly(N-isopropylacrylamide-co-acrylic acid)/cellulose laurate [CS/P(NIPAAm-co-AAc/CL] blend for transdermal multidrug delivery applications. The scanning electron microscopy (SEM) and dynamic light scattering (DLS) results showed that the diameter sizes of samples were in the range from 200 to 300nm along with a narrow size distribution. Also, the CS-based nanoparticles containing tretinoin and clindamycin phosphate prepared using microfluidic technique exhibited a sustained control release of the drugs as well as minimum inhibitory and bactericidal concentrations compared to the samples fabricated via bulk mixing method...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28211633/painful-nipple-hyperkeratosis-secondary-to-vemurafenib
#4
Emily S Carr, Shannon C Brown, Katherine H Fiala
Vemurafenib is a selected BRAF kinase inhibitor approved for treating metastatic or unresectable melanoma, which has numerous cutaneous side effects unfortunately, including three previously reported cases of asymptomatic areola and/or nipple hyperkeratosis. We present the first case of painful bilateral nipple hyperkeratosis secondary to vemurafenib in an 84-year-old woman. She was successfully treated with tretinoin 0.05% cream that allowed her to comfortably continue treatment. With increased awareness of this condition, we found a second case of asymptomatic nipple hyperkeratosis secondary to vemurafenib in our clinic...
February 17, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28210390/a-case-of-lichen-planus-pigmentosus-with-facial-dyspigmentation-responsive-to-combination-therapy-with-chemical-peels-and-topical-retinoids
#5
Marisa Wolff, Nina Sabzevari, Charles Gropper, Cindy Hoffman
Lichen planus pigmentosus is a photodistributed dyschromia of unknown etiology described clinically as hyperpigmented gray-blue or brown-black macules or patches in a photodistributed pattern. Although there has been some debate, lichen planus pigmentosus is considered by many to be a separate diagnostic entity from ashy dermatosis or erythema dyschromicum perstans, which shares similar characteristics. Various treatment strategies have been applied to help resolve or improve the appearance of lichen planus pigmentosus lesions; however, an optimal treatment method is yet to be elucidated...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28114204/treatment-of-postinflammatory-hyperpigmentation-with-a-combination-of-glycolic-acid-peels-and-a-topical-regimen-in-dark-skinned-patients-a-comparative-study
#6
Rashmi Sarkar, Nisha V Parmar, Sheilly Kapoor
BACKGROUND: Facial postinflammatory hyperpigmentation (PIH) is challenging to manage in patients with skin of color because of the risk of subsequent treatment-related hyperpigmentation. OBJECTIVE: To evaluate the safety and efficacy of combining glycolic acid (GA) peels with a modified Kligman formula (MKF) containing hydroquinone 2%, tretinoin 0.05%, and hydrocortisone 1% for the treatment of facial PIH in Indian patients. METHODS: Thirty Indian patients (Fitzpatrick skin Types III-V) with facial PIH were randomly assigned to 2 groups of 15 each...
April 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28108299/mouse-model-of-hydroquinone-hypersensitivity-via-innate-and-acquired-immunity-and-its-promotion-by-combined%C3%A2-reagents
#7
Kanan Bando, Yukinori Tanaka, Toshinobu Kuroishi, Keiichi Sasaki, Teruko Takano-Yamamoto, Shunji Sugawara, Yasuo Endo
We established a mouse model of contact hypersensitivity (CHS) to hydroquinone (HQ), a widespread chemical in our environment. HQ was painted onto flanks; then, HQ was challenged by painting onto ear pinnas on days 7 and 14. The CHS after the second challenge was markedly greater than that after the first challenge. Both challenges increased thymic stromal lymphopoietin and T helper type 2 cytokines in ear pinnas, whereas IFN-γ (typical T helper type 1 cytokine) was decreased, despite an increase in IL-18 (typical IFN-γ inducer)...
May 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28106291/ocular-effects-of-sulfur-mustard-and-therapeutic-approaches-a-review
#8
Yunes Panahi, Seyyed Mahdi Rajaee, Amirhossein Sahebkar
Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28095562/the-efficacy-of-q-switched-nd-yag-1064-nm-laser-in-recalcitrant-macular-amyloidosis-a-case-report
#9
Nevil Khurana, Christine Urman
Macular amyloidosis typically presents as small, dusky-brown or greyish pigmented macules, the result of altered keratin deposition. Treatment of these hyperpigmented regions with topical and systemic therapies remains challenging, however Q-Switched neodymi- um-doped yttrium aluminum garnet (ND:YAG) laser has proven to be an effective treatment modality to reduce hyperpigmentation. In this case report we investigated the ef cacy of Q-Switched Nd:YAG laser treatment on a 34-year old woman with recalcitrant macular amyloidosis who failed to respond to over-the-counter bleaching creams...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28088997/predictors-of-actinic-keratosis-count-in-patients-with-multiple-keratinocyte-carcinomas-a-cross-sectional-study
#10
Julia A Siegel, Adam J Luber, Martin A Weinstock
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28070082/evaluation-of-structural-isomers-molecular-interactions-reactivity-descriptors-and-vibrational-analysis-of-tretinoin
#11
T Karthick, Poonam Tandon, Swapnil Singh
Tretinoin is known to be a pharmaceutical drug for treating acne vulgaris, keratosis pilaris, and acute promyelocytic leukemia. In order to reveal the possible conformers of tretinoin, the energies of all the conformers through rotational bonds have been evaluated by systematic rotor search analysis. The intramolecular interactions ranging from strong hydrogen bonds to weak van der Waals forces present in tretinoin have been distinguished with the help of electron density mapping and wavefunction analysis. The global reactivity descriptors and Fukui functions of tretinoin have been calculated and discussed...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28052368/synthesis-and-activity-of-the-salicylic-acid-ester-of-bakuchiol-in-psoriasis-surrogate-keratinocytes-and-skin-substitutes
#12
S Ma, K Gobis, W R Swindell, R Chaudhuri, R Bojanowski, K Bojanowski
BACKGROUND: Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient compliance. Development of retinoid analogues with minimal AEs would allow a broader and more compliant use. AIM: To synthesise a novel molecule, bakuchiol salicylate (bakusylan), with a modulatory gene expression profile similar to retinoids, using as reference three prescription retinoids: tretinoin, tazarotene and adapalene...
April 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28024127/combined-therapy-in-vulvar-lichen-sclerosus-does-topical-tretinoin-improve-the-efficacy-of-mometasone-furoate
#13
Alessandro Borghi, Sara Minghetti, Giulia Toni, Annarosa Virgili, Monica Corazza
Purpose To assess efficacy and safety profile of combining a potent corticosteroid with a retinoid in in the treatment of vulvar lichen sclerosus (VLS). Methods We retrospectively compared 21 VLS patients treated with tretinoin (T) in short contact therapy and mometasone furoate (MMF) (group A) and 20 treated with cold cream (CC) and MMF (group B) for 5 consecutive days/week for 12 weeks. The efficacy parameters were the response rate, the percentage of patients achieving an improvement from baseline of ≥75% in subjective and objective scores, and the mean reduction in subjective and objective scores...
December 26, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27999648/comparison-of-long-pulsed-alexandrite-laser-and-topical-tretinoin-ammonium-lactate-in-axillary-acanthosis-nigricans-a-case-series-of-patients-in-a-before-after-trial
#14
Amirhoushang Ehsani, Pedram Noormohammadpour, Azadeh Goodarzi, Mostafa Mirshams Shahshahani, Seyede Pardis Hejazi, Elhamsadat Hosseini, Arghavan Azizpour
BACKGROUND: Acanthosis nigricans (AN) is a brown to black, velvety hyperpigmentation of the skin that usually involves cutaneous folds. Treatment of AN is important regarding cosmetic reasons and various therapeutic modalities have been used for these purposes. The goal of this study was to compare the effectiveness of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate for treatment of axillary-AN. METHODS: Fifteen patients with bilateral axillary-AN were studied in Razi Hospital, Tehran, Iran...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27984170/autism-genes-are-selectively-targeted-by-environmental-pollutants-including-pesticides-heavy-metals-bisphenol-a-phthalates-and-many-others-in-food-cosmetics-or-household-products
#15
REVIEW
C J Carter, R A Blizard
The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG's) from the Autworks database to interrogate ∼1 million chemical/gene interactions in the comparative toxicogenomics database. Any bias towards ASG's was statistically determined for each chemical. Many suspect compounds identified in epidemiology, including tetrachlorodibenzodioxin, pesticides, particulate matter, benzo(a)pyrene, heavy metals, valproate, acetaminophen, SSRI's, cocaine, bisphenol A, phthalates, polyhalogenated biphenyls, flame retardants, diesel constituents, terbutaline and oxytocin, inter alia showed a significant degree of bias towards ASG's, as did relevant endogenous agents (retinoids, sex steroids, thyroxine, melatonin, folate, dopamine, serotonin)...
October 27, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27976510/evaluation-of-salicylic-acid-peeling-in-comparison-with-topical-tretinoin-in-the-treatment-of-postinflammatory-hyperpigmentation
#16
Basma Morad Mohamed Ali, Shereen Farouk Gheida, Nageh Ahmed El Mahdy, Shery Nashaat Sadek
BACKGROUND: Postinflammatory hyperpigmentation (PIH) is an acquired hyperpigmentation that involves areas of prior cutaneous inflammation. In addition to prevention, there are a variety of medications and procedures used to treat PIH. AIM OF THE WORK: The aim of this work was to evaluate the efficacy, tolerability, and safety of salicylic acid peeling in comparison with topical tretinoin in the treatment of PIH. PATIENTS AND METHODS: This study included forty-five patients with PIH lesions...
December 15, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27886445/beard-hair-density-increase-a-possible-role-of-topical-tretinoin-application
#17
Michelangelo Vestita, Giuseppe Giudice, Domenico Bonamonte, Doriana Apruzzi, Angela Filoni
No abstract text is available yet for this article.
November 25, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27761082/retinoids-literature-review-and-suggested-algorithm-for-use-prior-to-facial-resurfacing-procedures
#18
Patrick J Buchanan, Robert H Gilman
Vitamin A-containing products have been used topically since the early 1940s to treat various skin conditions. To date, there are four generations of retinoids, a family of Vitamin A-containing compounds. Tretinoin, all-trans-retinoic acid, is a first-generation, naturally occurring, retinoid. It is available, commercially, as a gel or cream. The authors conducted a complete review of all studies, clinical- and basic science-based studies, within the literature involving tretinoin treatment recommendations for impending facial procedures...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27746652/a-prospective-split-face-comparative-study-of-periorbital-wrinkle-treatments-fractional-erbium-doped-yttrium-aluminum-garnet-laser-intense-pulsed-light-and-topical-0-1-tretinoin-cream
#19
So Eun Park, Sang Seok Kim, Chul Woo Kim, Young Her
No abstract text is available yet for this article.
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27698500/arsenic-trioxide-and-tretinoin-aso-atra-for-acute-promyelocytic-leukemia-apl
#20
Erin Damery, Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr., President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
September 2016: Hospital Pharmacy
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