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https://www.readbyqxmd.com/read/29779482/nanocrystals-technology-for-transdermal-delivery-of-water-insoluble-drugs
#1
Yangyang Liu, Beibei Yan, Juan Zhao, Lulu Wang, Yu Gu, Ping Chang, Yancai Wang
The poor penetration and low bioavailability are main challenges for transdermal drug delivery. Nanocrystals technology is an attractive method for water insoluble drug transdermal delivery, as the literature demonstrated that the penetration and bioavailability of the transdermal delivered water insoluble drugs was significantly enhanced and improved by the nanocrystals technology. Currently, the nanocrystals technology has been applied in transdermal delivery of cosmeceutical and for therapy skin diseases, such as diclofenac acid, tretinoin and rutin...
May 18, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29762736/comparative-transcriptome-analysis-of-rumen-papillae-in-suckling-and-weaned-japanese-black-calves-using-rna-sequencing
#2
Koki Nishihara, Daichi Kato, Yutaka Suzuki, Dahye Kim, Misato Nakano, Yu Yajima, Satoshi Haga, Miwa Nakano, Hiroshi Ishizaki, Ryouka Kawahara-Miki, Tomohiro Kono, Kazuo Katoh, Sang-Gun Roh
The length and density of rumen papillae starts to increase during weaning and growth of ruminants. This significant development increases the intraruminal surface area and the efficiency of VFA (acetate, propionate, butyrate, etc.) uptake. Thus, it is important to investigate the factors controlling the growth and development of rumen papillae during weaning. This study aimed to compare the transcriptomes of rumen papillae in suckling and weaned calves. Total RNA was extracted from the rumen papillae of 10 male Japanese Black calves (5 suckling calves, 5 wk old; 5 weaned calves, 15 wk old) and used in RNA-sequencing...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29704456/tretinoin-0-05-cream-versus-5-peel-for-photoaging-and-field-cancerization-of-the-forearms-randomized-evaluator-blinded-clinical-trial
#3
J M Sumita, H A Miot, J L M Soares, A C P Raminelli, S M Pereira, M M Ogawa, F R Picosse, L R S Guadanhim, M M S S Enokihara, G R Leonardi, E Bagatin
BACKGROUND: Topical tretinoin cream is the gold standard treatment for skin aging, particularly photoaging. The purpose of tretinoin peel is to obtain similar results but in a shorter time, however there have been few controlled trials on its effectiveness. OBJECTIVE: To compare efficacy and safety of tretinoin 0.05% cream and 5% as a peeling agent on photoaging and field cancerization of the forearms. METHODS: Clinical trial with therapeutic intervention, prospective, randomized (computer-generated randomization list), parallel, comparative (intrasubject) and evaluator-blinded (except for histology and immunohistochemistry), including twenty-four women (48 forearms) aged over 60 years who have not undergone hormone replacement, and categorized as Fitzpatrick skin phototype II or III...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29701622/platelet-rich-plasma-versus-tretinoin-in-treatment-of-striae-distensae-a-comparative-study
#4
Hend D Gamil, Samia A Ibrahim, Howyda M Ebrahim, Waleed Albalat
BACKGROUND: Striae distensae (SD) are dermal scars associated with atrophy of the epidermis. OBJECTIVE: To evaluate the effect and safety of intralesional injection of platelet-rich plasma (PRP) versus topical tretinoin 0.05% in treatment of SD. METHODS: Thirty patients (27 females and 3 males) had bilateral striae distensae were enrolled in this study. In every patient, half of the selected striae were treated with PRP intralesional injection...
May 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29547020/comparative-study-of-ablative-fractional-photothermolysis-versus-topical-retinoid-cream-in-the-treatment-of-idiopathic-guttate-hypomelanosis
#5
Won Seon Koh, Jeong Eun Kim, Young Suck Ro, Joo Yeon Ko
BACKGROUND: Despite various treatments attempts, no prospective studies have compared the different therapeutic modalities for treatment of idiopathic guttate hypomelanosis (IGH). This study aimed to compare the efficacy of CO2 fractional laser (CO₂FL), Er:YAG fractional laser (EYFL), and 0.025% topical tretinoin for treating IGH. MATERIALS AND METHODS: A total of 122 lesions were analyzed from 18 patients (mean age, 70.00 ± 20.00 years). Treatment outcome evaluations included the visual analog scale (VAS) to assess lesion severity, investigator's global assessment (IGA) to assess the extent of improvement, and patient's satisfaction score (PSS)...
March 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29532749/nanotechnological-advances-for-cutaneous-release-of-tretinoin-an-approach-to-minimize-side-effects-and-improve-therapeutic-efficacy
#6
Ana Claudia Pompeu Raminelli, Valeria Romero, Mohammad H Semreen, Gislaine Ricci Leonardi
The clinical efficacy of the topical tretinoin is widely studied and has been well established for many therapeutic interventions, among some, photoaging, acne, and melasma. However, the side effects, mainly cutaneous irritation, erythema, xerosis and peeling, remain major obstacle to the patient compliance. Besides, the insight regarding the drug delivery profile is essential to understand the therapeutic action of the drug. Herein we highlight further advances and an update on tretinoin delivery systems such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, cyclodextrins, nanostructured polymers and other technological systems that reduce its side effects and improve the permeation profile to potentiate efficacy and drug safety on the skin...
March 12, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29458017/synergistic-and-additive-effects-of-atra-in-combination-with-different-anti-tumor-compounds
#7
REVIEW
Eduarda Schultze, Tiago Collares, Caroline G Lucas, Fabiana K Seixas
All-trans retinoic acid (ATRA), a derivative of vitamin A, has been shown to potentiate cancer chemotherapy due to its ability to induce signals for cell differentiation or death, and inhibit cell proliferation. The combination of ATRA with taxoids, kinase inhibitors, natural compounds, retinoids, ER or HER2 inhibitors, chemotherapeutic drugs, proteasome inhibitors and nanoformulations of tretinoin have demonstrated additive or synergistic effects in anti-cancer activities. The mechanisms by which the compounds exert their synergistic effects depend on the tumor and the cell type...
April 1, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29437029/formulation-and-in-vitro-and-ex-vivo-evaluation-of-tretinoin-loaded-cubosomal-gel-for-acne-treatment
#8
Shruti Sureka, Gaurav Gupta, Mohit Agarwal, Anurag Mishra, Santosh K. Singh, Ravindra P Singh, Sushil K Sah, Terezinha de Jesus Andreoli Pinto, Kamal Dua
OBJECTIVE: The current work was attempted to formulate and evaluate the topical sustained release delivery systems called cubosomes containing Tretinoin for the acne treatment. The recent patents on various formulations of tretinoin (EP0408370A2) helped in selecting a new formulation and evaluation. METHODS: Tretinoin loaded cubosomes were prepared by bottom-up technique, using varying the concentration of lipid and surfactant and keeping the drug concentration constant, a total of nine formulations of tretinoin was developed...
February 13, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29386852/a-case-of-atrophoderma-vermiculatum-showing-a-good-response-to-topical-tretinoin
#9
Young Chae Lee, Sook-Ja Son, Tae Young Han, June Hyunkyung Lee
No abstract text is available yet for this article.
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29383779/erythema-directed-digital-photography-for-the-enhanced-evaluation-of-topical-treatments-for-acne-vulgaris
#10
G Micali, F Dall'Oglio, A Tedeschi, F Lacarrubba
BACKGROUND: Erythema-directed digital photography is a novel method for evaluating the efficacy and tolerability of topical acne treatments. Here, we describe three case reports in which erythema-directed digital photography was used to evaluate acne before and after up to 12 weeks of treatment with clindamycin 1%/tretinoin 0.025% (Clin-RA). MATERIALS AND METHODS: Erythema-directed digital photography was used to evaluate acne in three patients with mild-to-moderate facial acne, two of whom had refused to continue previous topical acne treatment (benzoyl peroxide 5% and clindamycin 1%/benzoyl peroxide 5%) due to persistent irritation...
January 31, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29356582/treating-tretinoin-ostealgia-with-pamidronate
#11
Robert Mancini, Mallori Hooker, Travis Williams
No abstract text is available yet for this article.
April 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29205474/successful-treatment-of-facial-milia-in-an-infant-with-orofaciodigital-syndrome-type-1
#12
Hallie B Hinen, Robert M Gathings, Marshall Shuler, Lara Wine Lee
We report the successful treatment of multiple facial milia with manual extraction and tretinoin in a child with orofaciodigital syndrome type 1. Treatment with topical medications may be insufficient in individuals with orofaciodigital syndrome type 1, and pitted scarring is often a sequala. This case demonstrates that manual extraction is well tolerated and effective in the treatment of multiple milia. In addition, clinicians need to be aware of this rare genetic condition, which commonly presents de novo and can lead to significant morbidity if untreated...
January 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29186249/tretinoin-peel-a-critical-view
#13
REVIEW
Juliana Mayumi Sumita, Gislaine Ricci Leonardi, Ediléia Bagatin
The tretinoin peel, also known as retinoic acid peel, is a superficial peeling often performed in dermatological clinics in Brazil. The first study on this was published in 2001, by Cuce et al., as a treatment option for melasma. Since then, other studies have reported its applicability with reasonable methodology, although without a consistent scientific background and consensus. Topical tretinoin is used for the treatment of various dermatoses such as acne, melasma, scars, skin aging and non-melanoma skin cancer...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29141062/management-of-severe-acne-vulgaris-with-topical-therapy
#14
Linda Stein Gold, Hilary E Baldwin, Tina Lin
<p>Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potential of fixed combination topical therapies to treat severe acne...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29138996/ichthyosiform-pityriasis-rubra-pilaris-like-eruption-secondary-to-ponatinib-therapy-case-report-and-literature-review
#15
Ariel E Eber, Alyx Rosen, Kate E Oberlin, Alessio Giubellino, Paolo Romanelli
Tyrosine kinase inhibitors have revolutionized the chemotherapy arena as targeted therapies for a multitude of malignancies. They are more selective than conventional chemotherapy, and often elicit fewer systemic adverse events, however toxicities still exist. Cutaneous toxicities are common and their management presents a novel challenge to physicians and patients. Ponatinib is a third-generation tyrosine kinase inhibitor increasingly reported to cause cutaneous eruption. A 50-year-old woman with a history of chronic myelogenous leukemia presented with a 4-month history of worsening atrophic and ichthyosiform pink plaques involving the axillae, thighs and abdomen; red patches were also observed on the cheeks and forehead...
November 14, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29031198/tretinoin-loaded-lipid-core-nanocapsules-overcome-the-triple-negative-breast-cancer-cell-resistance-to-tretinoin-and-show-synergistic-effect-on-cytotoxicity-induced-by-doxorubicin-and-5-fluororacil
#16
Eduarda Schultze, Julieti Buss, Karine Coradini, Karine Rech Begnini, Silvia S Guterres, Tiago Collares, Ruy Carlos Ruver Beck, Adriana R Pohlmann, Fabiana Kömmling Seixas
Nanostructured drug delivery systems have been extensively studied, mainly for applications in cancer therapy. The advantages of these materials include protection against drug degradation and improvement in both the relative solubility of poorly water soluble drugs as in targeting of therapy, due to the enhanced permeability and retention effect on tumor sites. In this work, we evaluate the antitumor activity of tretinoin-loaded lipid core nanocapsules (TT-LNC) in a tretinoin-resistant breast cancer cell-line, MDA-MB- 231, as well as the synergistic effect of combination of this treatment with 5-FU or DOXO...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29024079/the-preadolescent-acne-microbiome-a-prospective-randomized-pilot-study-investigating-characterization-and-effects-of-acne-therapy
#17
Carrie C Coughlin, Shane M Swink, Joseph Horwinski, Georgia Sfyroera, Julia Bugayev, Elizabeth A Grice, Albert C Yan
BACKGROUND/OBJECTIVES: Acne, a common pediatric disease, tends to be more comedonal in preadolescents, whereas older individuals are more likely to have inflammatory lesions in addition to comedones. Thus the microbiome of preadolescents may be different. In this pilot study we aimed to characterize the preadolescent acne microbiome, compare the microbiome in preadolescents with and without acne, and investigate changes in the microbiome after topical treatment with benzoyl peroxide or a retinoid in a small cohort of preadolescents...
November 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28980033/-tretinoin-one-retinoid-many-dosage-forms
#18
A Melhorn
No abstract text is available yet for this article.
November 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28871935/topical-imiquimod-is-an-effective-and-safe-drug-for-molluscum-contagiosum-in-children
#19
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28762645/efficacy-and-tolerability-of-a-double-conjugated-retinoid-cream-vs-1-0-retinol-cream-or-0-025-tretinoin-cream-in-subjects-with-mild-to-severe-photoaging
#20
David H McDaniel, Christopher Mazur, Mitchell S Wortzman, Diane B Nelson
BACKGROUND: Topical retinoids are used to treat the visible signs of photoaging. While efficacious, they are irritating. OBJECTIVE: Evaluate the effectiveness and tolerability of a double-conjugate retinoid cream (AlphaRet Overnight Cream; AHA-Ret) in improving visible signs of photoaging vs 1.0% retinol or 0.025% tretinoin. METHODS: A 12-week, split-face, randomized trial was conducted in 48 female subjects, aged 30-65 years with mild to severe photodamage...
December 2017: Journal of Cosmetic Dermatology
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