Read by QxMD icon Read


Michelangelo Vestita, Giuseppe Giudice, Domenico Bonamonte, Doriana Apruzzi, Angela Filoni
No abstract text is available yet for this article.
November 25, 2016: Dermatologic Therapy
Patrick J Buchanan, Robert H Gilman
Vitamin A-containing products have been used topically since the early 1940s to treat various skin conditions. To date, there are four generations of retinoids, a family of Vitamin A-containing compounds. Tretinoin, all-trans-retinoic acid, is a first-generation, naturally occurring, retinoid. It is available, commercially, as a gel or cream. The authors conducted a complete review of all studies, clinical- and basic science-based studies, within the literature involving tretinoin treatment recommendations for impending facial procedures...
July 2016: Journal of Cutaneous and Aesthetic Surgery
So Eun Park, Sang Seok Kim, Chul Woo Kim, Young Her
No abstract text is available yet for this article.
October 2016: Annals of Dermatology
Erin Damery, Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr., President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
September 2016: Hospital Pharmacy
Stefano Veraldi, Luisa C Rossi, Mauro Barbareschi
Retinoic acid is a physiological compound of human blood. Blood levels range from 1.000 to 7.000 pg/ml (usually 1.500-5.000 pg/ml). Results of studies on absorption of topical retinoic acid in laboratory animals, although rather conflicting, demonstrate that it induces plasma concentrations which are well below concentrations caused by non teratogenic oral doses. In humans, minimal percutaneous absorption of tretinoin was observed after topical applications. Neither single dose nor long term treatment with topical tretinoin affect the endogenous levels of retinoic acid or its metabolites...
September 6, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Abhijeet Kumar Jha, Rajesh Sinha, Smita Prasad
BACKGROUND: Topical corticosteroids (TC) are being misused widely on the face without a prescription from the dermatologist. AIM: To evaluate the misuse of TC-containing preparations on the face and the adverse effects due to its application. MATERIALS AND METHODS: A questionnaire-based analysis was done among patients attending the dermatology outpatient department of a tertiary care hospital between March 2014 and March 2015. Patients with various facial dermatoses were asked about their current use of topical preparations and on further followup questioning, those who revealed the use of TCs (25g or more) continuously or intermittently for a minimum duration of four weeks were included in the study and observed for local adverse effects...
July 2016: Indian Dermatology Online Journal
John P McCook, Thomas J Stephens, Lily I Jiang, Robert M Law, Vincent Gotz
PURPOSE: To examine the effect of sodium copper chlorophyllin complex on the expression of biomarkers of photoaged dermal extracellular matrix indicative of skin repair. PATIENTS AND METHODS: Following a previously published 12-day clinical assessment model, skin biopsy samples from the forearms of four healthy females with signs of photoaged skin were obtained and samples were analyzed by immunohistochemistry for key biomarkers of aging skin after each subject was treated with a test material consisting of a gel containing a liposomal dispersion of sodium copper chlorophyllin complex 0...
2016: Clinical, Cosmetic and Investigational Dermatology
Vivek M Ghate, Shaila A Lewis, Prabhakara Prabhu, Akhilesh Dubey, Nilkumar Patel
Cosmetic skin care products currently in the market demonstrate an increasing trend toward antiaging products. Selection of the right formulation approach is the key to successful consumer acceptance. Nanostructured lipid carriers (NLCs) for dermal application can render added benefits to the formulation. Tretinoin a derivative of vitamin A, is a retinoid with anti-aging and anti-acne potential. The present study was aimed at formulating NLCs of tretinoin for reducing the skin irritation potential, increasing the drug loading capacity and prolonging the duration of action...
August 9, 2016: European Journal of Pharmaceutics and Biopharmaceutics
Fatima Murtaza, Abdur Rahim Bangash, Arshad Khushdil, Sahibzada Mahmood Noor
OBJECTIVE: To compare the efficacy in terms of reduction in melasma area and severity index (MASI) score by more than 10 of a combination of 20% trichloro-acetic acid peel plus 5% topical magnesium ascorbyl phosphate versus 20% trichloroacetic acid peel alone in the treatment of epidermal melasma. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Department of Dermatology, Lady Reading Hospital (LRH), Peshawar, from May 2012 to May 2013...
July 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Mualla Polat, Bengu Altunay Tuman, Asli Sahin, Umit Dogan, Cetin Boran
No abstract text is available yet for this article.
August 9, 2016: Dermatologic Therapy
Umesh Karsandas Karia, Bela Bhemabhai Padhiar, Bela Jaswantbhai Shah
BACKGROUND: Striae are linear atrophic depressions that form in areas of dermal damage in the skin. As on date, no consensus or protocol exists for the treatment of stria rubra. Topical retinoids, chemical peels, microdermabrasion, radiofrequency, photothermolysis, intense pulsed light and lasers are some of the modalities used. AIMS AND OBJECTIVE: To compare the efficacy of various therapeutic modalities in striae rubra. METHODS: This prospective cohort study comprised of a total of fifty patients from August-2012 to October-2013 in a tertiary care center in Western India, Gujarat having striae rubra...
April 2016: Journal of Cutaneous and Aesthetic Surgery
Larry Lam, Lydia Chin, Ramesh C Halder, Bien Sagong, Sam Famenini, James Sayre, Dennis Montoya, Liudmilla Rubbi, Matteo Pellegrini, Milan Fiala
We have investigated transcriptional and epigenetic differences in peripheral blood mononuclear cells (PBMCs) of monozygotic female twins discordant in the diagnosis of amyotrophic lateral sclerosis (ALS). Exploring DNA methylation differences by reduced representation bisulfite sequencing (RRBS), we determined that, over time, the ALS twin developed higher abundances of the CD14 macrophages and lower abundances of T cells compared to the non-ALS twin. Higher macrophage signature in the ALS twin was also shown by RNA sequencing (RNA-seq)...
October 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Agnieszka Gunia-Krzyżak, Justyna Popiol, Henryk Marona
Hyperpigmentation disorders constitute important medical and aesthetical conditions. Dark areas or dark spots on the skin result from inappropriate amount and/or deposition of skin pigments - melanins. Several depigmenting agents, such as kojic acid, arbutin, aloesin, ellagic acid, resveratrol, azelaic acid, niacinamide, tretinoin, glycolic acid, lactic acid, and citric acid, have already been identified and are used in topical drugs or cosmetic formulations for the treatment of hyperpigmentations. However, these compounds are characterized by insufficient effectiveness and multiple adverse effects...
2016: Current Medicinal Chemistry
Woan-Ruoh Lee, Shing-Chuan Shen, Ibrahim A Aljuffali, Yin-Ku Lin, Chang-Wei Huang, Jia-You Fang
Use of the ablative laser has been approved to enhance topical drug penetration. Investigation into the usefulness of the non-ablative laser for assisting drug delivery is very limited. In this study, we explored the safety and efficacy of the non-ablative fractional erbium:glass (Er:glass) laser as an enhancement approach to promote drug permeation. Both pig and nude mouse skins were employed as transport barriers. We histologically examined the skin structure after laser exposure. The permeants of 5-aminolevulinic acid (ALA), imiquimod, tretinoin, peptide, dextrans and quantum dots (QD) were used to evaluate in vitro and in vivo skin passage...
September 20, 2016: European Journal of Pharmaceutical Sciences
Laurence Imhof, Reinhard Dummer, Jil Dreier, Isabel Kolm, Marjam J Barysch
BACKGROUND: Quality-switched (QS) laser therapy is a safe and well-established treatment option for removing solar lentigines. Triple combination therapy (TCT) with the active pharmaceutical ingredients hydroquinone 5%, tretinoin 0.03%, and dexamethasone 0.03% is often used for skin-lightening. OBJECTIVE: This prospective, open-label trial compares the efficacy and safety of a QS Ruby laser (QSRL) and a TCT in the treatment of solar lentigines. METHODS: In total, 15 patients with symmetrically distributed solar lentigines on the back of both hands were included...
July 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Rosa Romero-Jiménez, Irene Iglesias-Peinado, Ana Herranz-Alonso, María Sanjurjo-Sáez
OBJECTIVE: To review interactions between oral antineoplastic agents (OAAs) for the treatment of solid and hematological tumors and common food and medicinal plants. MATERIALS AND METHODS: All potential interactions between OAAs, medicinal plants and food were reviewed. OAAs were considered to be drugs for oral administration that have direct antitumor activity and were approved by the European Medicines Agency in April 2015. We performed the literature search in Pubmed(®) considering only medicinal plants and food...
November 2016: Journal of Cancer Research and Clinical Oncology
M M Tolba, R M El-Gamal
BACKGROUND: Adapalene is a retinoid analogue with actions similar to those of tretinoin. It is used in topical treatment of mild to moderate acne. A survey of the literature reveals that no spectrofluorimetric method has been reported yet for determination of ADP, so it was thought necessary to develop a highly sensitive stability indicating spectrofluorimetric method. RESULTS: Two highly sensitive spectrofluorimetric approaches were conducted for the assay of adapalene (ADP) in its gel...
2016: Chemistry Central Journal
B Sofen, G Prado, J Emer
Dyschromia is a leading cause for cosmetic consultation, especially in those with diverse skin types (mixture of ethnicities) and with the rise of non-core and untrained physicians performing cosmetic procedures. Melasma and post-inflammatory hyperpigmentation (PIH) account for the majority of cases and are characterized by pigmented macules and patches distributed symmetrically in sun-exposed areas of the forehead, cheeks, and chin in melasma, and irregularly in areas of inflammation or an inciting traumatic event with PIH...
January 2016: Skin Therapy Letter
Saman Ahmad Nasrollahi, Hurnaz Hassanzade, Azadeh Moradi, Mahsa Sabouri, Aniseh Samadi, Mansour Nassiri Kashani, Alireza Firooz
BACKGROUND AND AIM: Topical application of tretinoin (TRE) is followed by a high incidence of side effects. One method to overcome the problem is loading TRE into lipid nanoparticles. The potential safety of the nanoparticle materials has been always considered as a major concern. In this in vivo study, changes in human skin biophysical parameters including hydration, TEWL, erythema, and pH have been used to determine the safety of tretinoin loaded nano emulsion (NE) and nanostructured lipid carriers (NLC)...
May 12, 2016: Current Drug Delivery
Gulsen Tukenmez Demirci, Ayse Tulin Mansur, Ayse Tulin Gulec
A 21-year-old female presented with acne-like blackheads on brownish areas located on the cheek. She had been treated with neodymium-doped yttrium aluminium garnet (Nd-YAG) laser (1071 nm), 160 j/cm(2), three months ago for erythema and telangiectasia of her face. Afterwards, she developed atrophic, slightly depressed, hyperpigmented, 3-4 mm scars with superimposed tiny comedones within the treated areas. Topical treatment with tretinoin 0.05% cream on alternate days, and Sun Protection Factor (SPF) 50 sunscreen daily were commenced...
January 2016: Journal of Cutaneous and Aesthetic Surgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"