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https://www.readbyqxmd.com/read/29935212/confocal-microscopy-of-corneal-nerve-plexus-as-an-early-marker-of-eye-involvement-in-patients-with-type-2-diabetes
#1
Roberto dell'Omo, Francesco Cifariello, Serena De Turris, Vito Romano, Federico Di Renzo, Davide Di Taranto, Giovanni Coclite, Luca Agnifili, Leonardo Mastropasqua, Ciro Costagliola
PURPOSE: To measure the thickness and length of corneal nerves and the peri-papillary retinal nerve fiber layer (RNFL) thickness in patients recently diagnosed with diabetes mellitus (DM). METHODS: Twenty-two eyes of 22 patients recently diagnosed with type 2 DM and 22 eyes of 22 healthy individuals were consecutively enrolled. Central corneal sensitivity was measured using a Cochet-Bonnet esthesiometer, and corneal nerve length (CNL) and thickness (CNT) were evaluated through in vivo confocal microscopy...
June 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29935103/thinner-retinal-layers-are-associated-with-changes-in-the-visual-pathway-a-population-based-study
#2
Unal Mutlu, Mohammad K Ikram, Gennady V Roshchupkin, Pieter W M Bonnemaijer, Johanna M Colijn, Johannes R Vingerling, Wiro J Niessen, Mohammad A Ikram, Caroline C W Klaver, Meike W Vernooij
Increasing evidence shows that thinner retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), assessed on optical coherence tomography (OCT), are reflecting global brain atrophy. Yet, little is known on the relation of these layers with specific brain regions. Using voxel-based analysis, we aimed to unravel specific brain regions associated with these retinal layers. We included 2,235 persons (mean age: 67.3 years, 55% women) from the Rotterdam Study (2007-2012) who had gradable retinal OCT images and brain magnetic resonance imaging (MRI) scans, including diffusion tensor (DT) imaging...
June 23, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29934930/a-new-perspective-for-analyzing-clinical-characteristics-of-idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis-syndrome
#3
Xiao-Cui Liu, Mao-Nian Zhang, Bing Chen, Ying Li, Hou-Bin Huang
PURPOSE: We aimed to analyze the clinical characteristics of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome. Furthermore, we aimed to correlate the number and location of retinal aneurysms with the size of retinal non-perfusion area and neovascularization. METHODS: Six patients with IRVAN syndrome (1 male and 5 females, age 5-38 years) were enrolled in this study. Fundus fluorescein angiography (FFA) was used to determine the total number of retinal aneurysms, number of aneurysms within the first branch of the retinal artery, minimum distance between the non-perfusion margin and the optic disc, and the number of retinal aneurysms in each quadrant, as well as the type of neovascularization...
June 22, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29934802/iscev-extended-protocol-for-the-photopic-on-off-erg
#4
Maja Sustar, Graham E Holder, Jan Kremers, Claire S Barnes, Bo Lei, Naheed W Khan, Anthony G Robson
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On-Off ERG, and outlines common clinical applications. A light stimulus duration of 150-200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. The On-response occurs after the stimulus onset and has a negative a-wave and positive b-wave...
June 22, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29934636/clinical-significance-of-ectopic-inner-foveal-layers-in-patients-with-idiopathic-epiretinal-membranes
#5
Sibel Doguizi, Mehmet Ali Sekeroglu, Dilara Ozkoyuncu, Aslihan Esra Omay, Pelin Yilmazbas
BACKGROUND/OBJECTIVES: To evaluate the relationship between the presence of ectopic inner foveal layers (EIFL), choroidal thickness, and visual acuity (VA) in patients with epiretinal membranes (ERM) staged by spectral-domain optical coherence tomography (SD-OCT). SUBJECTS/METHODS: A total of 242 eyes of 121 patients with unilateral idiopathic ERM were prospectively evaluated. ERM stages were defined based on the SD-OCT staging system as stage 1: negligible morphological or anatomical disruption, retinal layers, and foveal pit are identified; stage 2: characteristic stretching of the outer nuclear layer, absence of foveal depression, retinal layers are identified; stage 3: continuous EIFL crossing the central foveal area, absence of foveal depression, retinal layers are identified; and stage 4: anatomical disruption of the fovea, continuous EIFL crossing the entire foveal area, retinal layers are distorted...
June 22, 2018: Eye
https://www.readbyqxmd.com/read/29934267/can-macula-and-optic-nerve-head-parameters-detect-glaucoma-progression-in-eyes-with-advanced-circumpapillary-retinal-nerve-fiber-layer-damage
#6
Fabio Lavinsky, Mengfei Wu, Joel S Schuman, Katie A Lucy, Mengling Liu, Youngseok Song, Julia Fallon, Maria de Los Angeles Ramos Cadena, Hiroshi Ishikawa, Gadi Wollstein
PURPOSE: To evaluate the ability of OCT optic nerve head (ONH) and macular parameters to detect disease progression in eyes with advanced structural glaucomatous damage of the circumpapillary retinal nerve fiber layer (cRNFL). DESIGN: Longitudinal study. PARTICIPANTS: Forty-four eyes from 37 patients with advanced average cRNFL damage (≤60 μm) followed up for an average of 4.0 years. METHODS: All patients were examined with spectral-domain OCT and visual field (VF) assessment during at least 4 visits...
June 19, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29933971/-retinal-vasculitis-and-systemic-diseases
#7
P Gascon, P-A Jarrot, F Matonti, G Kaplanski
Retinal vasculitis (RV) is an inflammation of retinal blood vessels that can be associated with uveitis or be isolated, and can induce vascular occlusion and retinal ischemia. Visual acuity can be severely affected in case of macular involvement or neovessel formation. The diagnosis relies on fundoscopy and fluorescein angiography. Systemic diseases may be associated with RV, the most frequently encountered are Behçet's disease, sarcoidosis or multiple sclerosis, all predominantly associated with venous involvement, whereas systemic lupus erythematosus and necrotizing vasculitis are less frequently observed and predominantly associated with arterial or mixed vasculitis...
June 19, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29933759/dendrobium-nobile-lindley-and-its-bibenzyl-component-moscatilin-are-able-to-protect-retinal-cells-from-ischemia-hypoxia-by-dowregulating-placental-growth-factor-and-upregulating-norrie-disease-protein
#8
Wen-Haur Chao, Ming-Yi Lai, Hwai-Tzong Pan, Huei-Wen Shiu, Mi-Mi Chen, Hsiao-Ming Chao
BACKGROUND: Presumably, progression of developmental retinal vascular disorders is mainly driven by persistent ischemia/hypoxia. An investigation into vision-threatening retinal ischemia remains important. Our aim was to evaluate, in relation to retinal ischemia, protective effects and mechanisms of Dendrobium nobile Lindley (DNL) and its bibenzyl component moscatilin. The therapeutic mechanisms included evaluations of levels of placental growth factor (PLGF) and Norrie disease protein (NDP)...
June 22, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29933288/diagnostic-criteria-and-treatment-algorithm-for-susac-syndrome
#9
Robert A Egan
BACKGROUND: Susac syndrome (SS) classically presents with the clinical triad of retinal artery occlusion, sensorineural hearing loss, and encephalopathy and the neuroimaging triad of white matter lesions, deep gray matter lesions, and leptomeningeal disease. However, patients can present with an incomplete clinical or neuroimaging triads making diagnosis difficult in certain situations. A standard treatment paradigm also is lacking in this illness. It is important for neuro-ophthalmologists to recognize clinical and radiographic findings that are pathognomonic for this syndrome and have a basic understanding of the available treatment options...
June 21, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29932924/the-role-of-uric-acid-in-the-pathogenesis-of-diabetic-retinopathy-based-on-notch-pathway
#10
Dan-Dan Zhu, Yun-Zhi Wang, Chen Zou, Xin-Ping She, Zhi Zheng
OBJECTIVE: Uric acid has been proposed as an independent risk factor of diabetic retinopathy. Although Notch signaling was reported to be affected in the presence of high concentrations of uric acid or glucose, the underlying mechanisms of hyperuricemia through the Notch signaling pathway to promote the development of diabetic retinopathy remain unknown. METHODS: We incubated human retinal endothelial cells (HRECs) with high glucose, high uric acid and high glucose plus high glucose respectively and evaluated the apoptosis rate in different treated cells by Tunel staining...
June 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29932012/choroideremia-molecular-mechanisms-and-development-of-aav-gene-therapy
#11
Maria I Patrício, Alun R Barnard, Kanmin Xue, Robert E MacLaren
INTRODUCTION: Choroideremia is an X-linked inherited retinal degeneration that causes blindness in afflicted males by middle age. The causative gene, CHM, plays a key role in intracellular trafficking pathways, and its disruption impairs cell homeostasis. Areas covered: The mechanism by which mutations in CHM cause choroideremia is still under debate. Here we describe the molecular defects in choroideremia cells regarding both the deficiency of prenylation and the involvement of Rab GTPases...
June 22, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29931830/time-to-steroid-treatment-in-severe-acute-optic-neuritis
#12
Gro Helen Dale, Thor Petersen, Kristina Bacher Svendsen, Tove Christensen, Gunnar Houen, Toke Bek
OBJECTIVES: Steroid treatment can accelerate visual recovery in patients with optic neuritis (ON), but it is unknown whether the timing of the start of treatment influences the outcome. The main purpose of this observational study was to assess the effect of early onset steroid treatment of ON on visual prognosis and retinal morphology. METHODS: Forty-nine patients with acute mild/moderate (n = 21) or severe (n = 28) ON, and an equal number of healthy controls were enrolled...
June 22, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29931682/hyaluronic-acid-modified-cationic-niosomes-for-ocular-gene-delivery-improving-transfection-efficiency-in-retinal-pigment-epithelium
#13
Yanmei Qin, Yongfeng Tian, Yang Liu, Dong Li, Hua Zhang, Yeqian Yang, Jianping Qi, Hao Wang, Li Gan
OBJECTIVES: Recent years, gene therapy to treat retinal diseases has been paid much attention. The key to successful therapy is utilizing smart delivery system to achieve efficient gene delivery and transfection. In this study, hyaluronic acid (HA) modified cationic niosomes (HA-C-niosomes) have been designed in order to achieve retinal pigment epithelium (RPE) cells targeted gene delivery and efficient gene transfection. METHODS: Cationic niosomes composed of tween 80/squalene/1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP) were prepared by the ethanol injection method...
June 21, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29931334/a-splicing-mutation-in-aryl-hydrocarbon-receptor-associated-with-retinitis-pigmentosa
#14
Yu Zhou, Shujin Li, Lulin Huang, Yeming Yang, Lin Zhang, Mu Yang, Wenjing Liu, Kim Ramasamy, Zhilin Jiang, Periasamy Sundaresan, Xianjun Zhu, Zhenglin Yang
No abstract text is available yet for this article.
June 21, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29931057/insulin-signalling-promotes-dendrite-and-synapse-regeneration-and-restores-circuit-function-after-axonal-injury
#15
Jessica Agostinone, Luis Alarcon-Martinez, Clare Gamlin, Wan-Qing Yu, Rachel O L Wong, Adriana Di Polo
Dendrite pathology and synapse disassembly are critical features of chronic neurodegenerative diseases. In spite of this, the capacity of injured neurons to regenerate dendrites has been largely ignored. Here, we show that, upon axonal injury, retinal ganglion cells undergo rapid dendritic retraction and massive synapse loss that preceded neuronal death. Human recombinant insulin, administered as eye drops or systemically after dendritic arbour shrinkage and prior to cell loss, promoted robust regeneration of dendrites and successful reconnection with presynaptic targets...
June 21, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29930992/imaging-the-deep-choroidal-vasculature-using-spectral-domain-and-swept-source-optical-coherence-tomography-angiography
#16
J Daniel Diaz, Jay C Wang, Patrick Oellers, Inês Lains, Lucia Sobrin, Deeba Husain, Joan W Miller, Demetrios G Vavvas, John B Miller
Purpose: To evaluate the deeper choroidal vasculature in eyes with various ocular disorders using spectral domain (SD) optical coherence tomography angiography (OCTA) and swept source (SS) OCTA. Methods: Patients underwent OCTA imaging with either SD-OCTA (Zeiss Cirrus Angioplex or Optovue AngioVue) or SS-OCTA (Topcon Triton). Retinal pigment epithelium (RPE) integrity, structural visualization of deep choroidal vessels on en face imaging, and OCTA of deep choroidal blood flow signal were analyzed...
May 2018: Journal of vitreoretinal diseases
https://www.readbyqxmd.com/read/29930739/circular-rna-znf609-regulates-retinal-neurodegeneration-by-acting-as-mir-615-sponge
#17
Jia-Jian Wang, Chang Liu, Kun Shan, Bai-Hui Liu, Xiu-Miao Li, Shu-Jie Zhang, Rong-Mei Zhou, Rui Dong, Biao Yan, Xing-Huai Sun
Glaucoma is a major cause of visual impairment characterized by progressive retinal neurodegeneration. Circular RNAs are a class of endogenous noncoding RNAs that regulate gene expression in eukaryotes. In this study, we investigated the role of cZNF609 in retinal neurodegeneration induced by glaucoma. Methods: qRT-PCR and Sanger sequencing were conducted to detect cZNF609 expression pattern during retinal neurodegeneration. Immunofluorescence staining was conducted to detect the effect of cZNF609 silencing on retinal neurodegeneration in vivo...
2018: Theranostics
https://www.readbyqxmd.com/read/29930534/postural-instability-induced-by-visual-motion-stimuli-in-patients-with-vestibular-migraine
#18
Yong-Hyun Lim, Ji-Soo Kim, Ho-Won Lee, Sung-Hee Kim
Patients with vestibular migraine are susceptible to motion sickness. This study aimed to determine whether the severity of posture instability is related to the susceptibility to motion sickness. We used a visual motion paradigm with two conditions of the stimulated retinal field and the head posture to quantify postural stability while maintaining a static stance in 18 patients with vestibular migraine and in 13 age-matched healthy subjects. Three parameters of postural stability showed differences between VM patients and controls: RMS velocity (0...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29930459/modified-transscleral-external-drainage-of-subretinal-fluid-in-high-bullous-exudative-retinal-detachment-due-to-coats-disease
#19
Shachi Rohan Desai, Omar Abdel Dayem, Arindam Chakravarti, Sundaram Natarajan
Surgical management of advanced coats' disease has always been a challenge to a surgeon. Various different techniques have been tried. With the advancement in surgical instruments and machines, surgeons are now modifying older surgical techniques. We have tried a novel minimally invasive surgical technique for the management of advanced coats' disease patient having high bullous exudative retinal detachment. Intravitreal injection of Bevacizumab at the end of the surgery has a role in such cases.
May 2018: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29930455/accidental-henpeck-as-a-cause-of-devastating-eye-injury
#20
Valerie Menezes, Ugam P S Usgaonkar
Ocular Trauma by the peck of a hen can cause grievious eye injuries. We report a rare case of uniocular blindness in a 5 year old girl ,following a hen peck which caused a penetrating eye injury along with a total retinal detachment.
May 2018: Oman Journal of Ophthalmology
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