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Fabian Spitzer, Gabor Balazs, Christian Graßl, Martin Keilwerth, Karsten Meyer, Manfred Scheer
A first systematic study of the activation of As4 by Co complexes is presented. Three different low-valent [LCo(tol)] (L = β-diiminato) complexes reveal different steric influences as well as the electronic influence of their adjacent substituents. Dipp (2,6-diisopropylphenyl) and dmp (2,6-dimethylphenyl) flanking groups were applied, one of the ligands with H backbone substituents (β-dialdiminate L0) and two with Me substituents (β-diketiminates L3 and L1). In the reaction with As4, different dinuclear products [(LCo)2As4] (LM = L0 (1), L1 (2), L3 (3)) were isolated, each of them representing an individually shaped [Co2As4] core in the solid state: octahedral in 1, prismatic in 2 and asterane-like in 3...
April 20, 2018: Angewandte Chemie
Zhe Huang, Mingpeng Yang, Hui You, Yang Xie
An improved method for the concurrent determination and separation of cations and anions by microchip electrophoresis with capacitively coupled contactless conductivity detection (ME-C4 D) is described. Two kinds of microchip structures were designed. The first microchip has a long bent separation channel. And for the defects of the first microchip, the second microchip with a Y-type separation channel has been proposed. The background electrolyte (BGE) composed of 20 mm His/MES and 0.01 mm CTAB was optimized for inhibiting the electroosmotic flow (EOF)...
April 20, 2018: Electrophoresis
Walavan Sivakumar, Michael Jensen, Julie Martinez, Michael Tanana, Nancy Duncan, Robert Hoesch, Jay K Riva-Cambrin, Craig Kilburg, Safdar Ansari, Paul A House
OBJECTIVE Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy...
April 20, 2018: Journal of Neurosurgery
David J Pagliarini
The young investigator award from the Protein Society was a special honor for me because, at its essence, the goal of my laboratory is to define what obscure proteins do. Years ago, I stumbled into mitochondria as a venue for this work, and these organelles continue to define the biological theme of my laboratory. Our approaches are fairly broad, reflecting my own somewhat unorthodox training among diverse scientific fields spanning organic synthesis, chemical biology, mechanistic biochemistry, signal transduction, and systems biology...
April 20, 2018: Protein Science: a Publication of the Protein Society
M A Peck, G R Hearne, C Obuah, J Darkwa
57Fe Mössbauer spectroscopy has been used to study electronic dispersions in complexes of Fe, Co, Ni and Pd anchored onto 3-ferrocenyl-5-methylpyrazolylmethylenepyridine and 3-ferrocenylpyrazolylmethylenepyridine ligands. Mössbauer spectroscopy shows that pyrazolyl-derivatizing of ferrocene increases the electron-density at the Fe-centre as well as facilitating the Fe to cyclopentadienyl ring back-donation of electron-density. The coordination of the ferrocenyl-pyrazolyl ligand to transition metals such as Fe, Co, Ni and Pd reduces the electron-density at the Fe-centre of the ferrocenyl moiety while increasing the electron-density at the coordinated metal centre, especially in the Fe complexes...
April 20, 2018: Physical Chemistry Chemical Physics: PCCP
Arnau Call, Federico Franco, Noufal Kandoth, Sergio Fernández, María González-Béjar, Julia Pérez-Prieto, Josep M Luis, Julio Lloret-Fillol
A new family of cobalt complexes with the general formula [CoII (OTf)2 (Y,X PyMe tacn)] ( 1R , Y,X PyMe tacn = 1-[(4-X-3,5-Y-2-pyridyl)methyl]-4,7-dimethyl-1,4,7-triazacyclononane, (X = CN ( 1CN ), CO2 Et ( 1CO2Et ), Cl ( 1Cl ), H ( 1H ), NMe2 ( 1NMe2 )) where (Y = H, and X = OMe when Y = Me ( 1DMM )) is reported. We found that the electronic tuning of the Y,X PyMe tacn ligand not only has an impact on the electronic and structural properties of the metal center, but also allows for a systematic water-reduction-catalytic control...
March 7, 2018: Chemical Science
E C Bridi, A A Leme-Kraus, B Aydin, R T Basting, A K Bedran-Russo
OBJECTIVE: The purpose of this study was to investigate the effects of aqueous solutions of different concentrations of titanium tetrafluoride (TiF4 ) on dentin matrix stability up to six months. DESIGN: Dentin specimens prepared from fifteen nonerupted molars were demineralized and randomly distributed into groups: 2.5% TiF4 , 4% TiF4, 1000 ppm NaF, and control (distilled water). The modulus of elasticity (ME) and dry masses of the dentin matrix were determined at baseline, and up to 6 months following treatment...
April 10, 2018: Archives of Oral Biology
Min Yang, Zhihua Tian, Bo Ma, Kaiying Jia, Hongli Zhang, Jing Fu, Wenwen Qin, Wei Zhao
Objective To establish a multiple-indirect immunofluorescence staining that can be used to detect several proteins in the same frozen section of hepatocellular carcinoma (HCC) tissues. Methods Laser scanning confocal microscopy (LSCM) was applied to scan the first group of antibodies against four proteins stained on the HCC tissues by the indirect immunofluorescence technique. The first group of antibodies and residual dye were removed by homologous species IgG Fab antibody blocking combined with chemical strip reagents (2-mercaptoethanol/dodecyl benzene sulfonic acid sodium/guanidine hydrochloride/sodium borohydride, β-ME/SDS/GnHCl/NaBH4)...
February 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Siyang Liu, Pengju Lin, Fangfang Niu, Pengju Zeng, Bin Zhang
A series of symmetric carbazole derivatives (CzP-H, CzP-CN, CzP-Me, and CzP-OMe), which comprise electron-donating and electron-drawing groups appending on a phenyl core, was synthesized and characterized in detail. These compounds exhibit excellent thermal stabilities, with thermal decomposition temperatures exceeding 400 °C. From the fluorescent spectra in film, CzP-H, CzP-Me, and CzP-OMe showed UV to blue-violet emission, with peaks at 396 nm, 402 nm, and 392 nm, respectively. The E 00 energies of CzP-H, CzP-CN, CzP-Me, and CzP-OMe were 3...
April 17, 2018: Materials
O Adeola, M N Anwar, M R Abdollahi, V Ravindran
Six hundred and eighty-four male Ross 308 broiler chicks were used to test the null hypothesis that post hatching age between day 0 and 21 does not affect utilization of energy in meat and bone meal (MBM). There were 6 replicate cages in each of 12 treatments consisting of 3 test diets (0, 40, or 80 g MBM/kg diets) at 4 feeding ages post hatching (day 0 to 7, 6 to 11, 10 to 16, or 15 to 21 post hatching) for a total of 72 cages in a randomized complete block design. Birds were assigned to the 12 treatments on day 0, fed a standard starter diet until they were switched to the test diets on day 0, 6, 10, or 15, and the number of birds per cage for day 0 to 7, 6 to 11, 10 to 16, or 15 to 21 were 12, 10, 8, or 8, respectively...
April 17, 2018: Poultry Science
Kelly L George, W Seth Horne
The prospect of recreating the complex structural hierarchy of protein folding in synthetic oligomers with backbones that are artificial in covalent structure ("foldamers") has long fascinated chemists. Foldamers offer complex functions from biostable scaffolds and have found widespread applications in fields from biomedical to materials science. Most precedent has focused on isolated secondary structures or their assemblies. In considering the goal of complex protein-like tertiary folding patterns, a key barrier became apparent...
April 19, 2018: Accounts of Chemical Research
Yu Zhang, Tia S Lee, Jeffrey L Petersen, Carsten Milsmann
Time-resolved emission spectroscopy for the luminescent zirconium complex Zr(Me PDP)2 (Me PDP = 2,6-bis(5-methyl-3-phenyl-1H-pyrrol-2-yl)pyridine) revealed a long-lived excited state with a lifetime τ = 325 ± 10 μs. Computational studies using time-dependent density functional theory (TD-DFT) were conducted to identify the nature of the luminescent excited state as a mixed triplet intraligand/ligand-to-metal charge transfer (3 IL/3 LMCT) state. Stern-Volmer experiments showed a strong dependence of the quenching rate on the redox potential of the quencher indicating photo-induced single electron transfer (SET) as the quenching pathway...
April 19, 2018: Journal of the American Chemical Society
Michael R Pranzatelli
The concept and recognized components of "neuroinflammation" are expanding at the intersection of neurobiology and immunobiology. Chemokines (CKs), no longer merely necessary for immune cell trafficking and positioning, have multiple physiologic, developmental, and modulatory functionalities in the central nervous system (CNS) through neuron-glia interactions and other mechanisms affecting neurotransmission. They issue the "help me" cry of neurons and astrocytes in response to CNS injury, engaging invading lymphoid cells (T cells and B cells) and myeloid cells (dendritic cells, monocytes, and neutrophils) (adaptive immunity), as well as microglia and macrophages (innate immunity), in a cascade of events, some beneficial (reparative), others destructive (excitotoxic)...
2018: Frontiers in Immunology
Aaron Schaal
No abstract text is available yet for this article.
April 2018: Nature
Pedro H Papotto, Bruno Silva-Santos
No abstract text is available yet for this article.
May 2018: Nature Immunology
Anne J Blaschke, Kristen M Holmberg, Judy A Daly, Amy L Leber, Jennifer Dien Bard, Ernest K Korgenski, Kevin M Bourzac, Kristen J Kanack
In pediatric practice it is common for infants under 2 months of age to undergo evaluation for sepsis when they are ill, often including lumbar puncture (LP) to assess for central nervous system (CNS) infection. The FilmArray® Meningitis/Encephalitis (ME) Panel is a newly approved test for rapid identification of CNS pathogens. Our objective was to study the epidemiology of CNS infection in young infants and the potential impact of rapid multiplex PCR on their care.A performance evaluation of the FilmArray ME Panel was conducted from 2/2014-9/2014 at 11 sites...
April 18, 2018: Journal of Clinical Microbiology
Emily Hahn
Nursing has been described as an art and a science. The scientific aspect of nursing can be learned in nursing school and in years of practice. However, the art of nursing is enriched by each nurse's connection with life experiences. The purpose of this article is to highlight my particular life experience with dance and to show how studying dance has helped me become the strong nursing leader I am today.
April 1, 2018: Creative Nursing
Kimberly Raines
Teenage pregnancy is a signifi cant social issue in the United States, resulting in increased levels of poverty. Most public health family planning efforts have traditionally focused on teaching teens the how-to of contraception, with little focus on teaching the why-to. During my time as a nurse practitioner in a public health department family planning clinic, I developed a method to open discussions with patients about the possibilities of a future that includes delayed childbearing. My experience with this strategy taught me that hope may indeed be the most powerful contraceptive of all...
April 1, 2018: Creative Nursing
E D Mauch, J M Young, N V L Serão, W L Hsu, J F Patience, B J Kerr, T E Weber, N K Gabler, J C M Dekkers
Residual feed intake (RFI) is the difference between observed and predicted feed intake of an animal, based on growth and maintenance requirements. In Yorkshire pigs, divergent selection for increased (Low RFI) and decreased (High RFI) RFI was carried out over 10 generations (G) while feeding a corn- and soybean-meal-based, higher-energy, lower-fiber (HELF) diet. In G8 to G10, representing 4 replicates, barrows and gilts (n = 649) of the RFI lines were fed the HELF diet and a diet incorporating coproducts that were lower in energy and higher in dietary fiber (LEHF)...
April 14, 2018: Journal of Animal Science
N C Manoukis, D H Cha, R M Collignon, T E Shelly
Methyl eugenol (ME) is a powerful semiochemical attractant to males of the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), and is the keystone of detection, control, and eradication programs against this polyphagous and highly invasive tephritid pest. Despite its status as a model lure against B. dorsalis, variation among individuals in their attraction is known, independent of the generally increasing attraction with age and decreases with previous exposure. Here we report that adult male B...
April 12, 2018: Journal of Economic Entomology
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