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https://www.readbyqxmd.com/read/28937874/can-a-label-help-me-drink-in-moderation-a-review-of-the-evidence-on-standard-drink-labelling
#1
Ashley Wettlaufer
INTRODUCTION: Understanding the concept of a standard drink (SD) is foundational knowledge to many public health policies aimed at reducing alcohol-related harms. These policies include adhering to low-risk drinking guidelines, screening brief intervention and referral activities, and counter alcohol-impaired driving initiatives. A lack of awareness of SDs might preclude the effectiveness of these interventions. A systematic review was conducted to review the evidence about how effective alcohol labels are in communicating SD information to the consumer...
September 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28937744/methane-c-h-activation-via-3d-metal-methoxide-complexes-with-potentially-redox-noninnocent-pincer-ligands-a-density-functional-theory-study
#2
Ahmad Najafian, Thomas R Cundari
This paper reports a density functional theory study of 3d transition-metal methoxide complexes with potentially redox-noninnocent pincer supporting ligands for methane C-H bond activation to form methanol (LnM-OMe + CH4 → LnM-Me + CH3OH). The three types of tridentate pincer ligands [terpyridine (NNN), bis(2-pyridyl)phenyl-C,N,N' (NCN), and 2,6-bis(2-phenyl)pyridine-N,C,C' (CNC)] and different first-row transition metals (M = Ti, V, Cr, Mn, Fe, Co, Ni, and Cu) are used to elucidate the reaction mechanism as well as the effect of the metal identity on the thermodynamics and kinetics of a methane activation reaction...
September 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28937469/outcome-of-a-resident-spine-surgical-skills-training-program
#3
Brian P Calio, Christopher K Kepler, John D Koerner, Jeffrey A Rihn, Paul Millhouse, Kris E Radcliff
STUDY DESIGN: Cadaver training lab. OBJECTIVE: To determine if a technical cadaver skills training lab for spinal surgery increases resident confidence, satisfaction in training, and perception of operating room safety. SUMMARY OF BACKGROUND DATA: Resident training is an important topic in the setting of work hour reform. The use of supplemental materials such as videos, sawbones, and simulators may become important to adequately train orthopedic residents...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28936960/-role-of-phosphorylated-moesin-in-the-injury-of-pulmonary-microvascular-endothelial-cells-of-rats-and-its-mechanism
#4
Gang Wang, Gengyun Sun
OBJECTIVE: To investigate the role of phosphorylated Moesin (p-Moesin) in the injury of pulmonary microvascular endothelial cells (PMVECs) of rats induced by tumor necrosis factor-α (TNF-α), and to approach the impact of Rac1 signal pathway on Moesin phosphorylation. METHODS: PMVECs of rats were cultured in vitro and passed on to the third generation, and the TNF-α time-effect experiment, dose-effect experiment and Rac1 signaling pathway intervention experiment were performed respectively...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28936508/rapid-and-ordered-carbonylation-and-oxygenation-of-a-cobalt-ii-methyl
#5
Regina R Reinig, Ellie L Fought, Arkady Ellern, Theresa L Windus, Aaron D Sadow
The oxidative carbonylation of To(M)CoMe (1; To(M) = tris(4,4-dimethyl-2-oxazolinyl)phenylborate) involves its rapid, reversible reaction with CO to form To(M)Co{C(O)Me}CO (2) followed by rapid reaction with O2 yielding To(M)CoOAc (3), in contrast to the slow direct carboxylation of To(M)CoMe by CO2.
September 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28935264/a-potent-neuromedin-u-receptor-2-selective-alkylated-peptide
#6
Naoki Nishizawa, Yoko Kanematsu-Yamaki, Masaaki Funata, Hiroaki Nagai, Ayako Shimizu, Hisashi Fujita, Junichi Sakamoto, Shiro Takekawa, Taiji Asami
Neuromedin U (NMU) mediates various physiological functions via NMUR1 and NMUR2 receptors. NMUR2 has been considered a promising treatment option for diabetes and obesity. Although NMU-8, a shorter peptide, has potent agonist activity for both receptors, it is metabolically unstable. Therefore, NMU-8 analogs modified with long-chain alkyl moieties via a linker were synthesized. An octadecanoyl analog (17) with amino acid substitutions [αMePhe(19), Nle(21), and Arg(Me)(24)] and a linker [Tra-γGlu-PEG(2)] dramatically increased NMUR2 selectivity, with retention of high agonist activity...
September 9, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28934172/topical-nano-and-microemulsions-for-skin-delivery
#7
REVIEW
Christofori M R R Nastiti, Thellie Ponto, Eman Abd, Jeffrey E Grice, Heather A E Benson, Michael S Roberts
Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation...
September 21, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28932581/catch-me-if-you-can-how-to-make-the-best-use-of-pleural-effusion
#8
Lianjun Lin, Qian Han, Zhonghui Liu, Huiying Xu, Yanping Wu, Jixin Zhang, Xinmin Liu
Etiology diagnosis of pleural effusion is a commonly encountered yet challenging problem. How to make the best use of pleural effusion evokes thinking. Myelomatous pleural effusion (MPE) is a rare condition and has been reported sporadically. We report an extremely rare case of multiple myeloma (MM) [IgD-lambda (λ) type, stage III B] with MPE as initial presentation and complicated with massive pericardial effusions during the progression of the disease. Cytological identification of malignant plasma cells in pleural effusion is the most direct method to diagnose MPE...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932425/crystal-structure-of-unsymmetrical-%C3%AE-di-imine-palladium-ii-complex-cis-arn-c-me-et-c-nar-pdcl2-ar-2-6-ipr-2c6h3
#9
Shravan Kumar Ellandula, Cosmos Opoku Amoako, Joel T Mague, Perumalreddy Chandrasekaran
The unsymmetrical α-di-imine ligand N-{2-[2,6-bis-(propan-2-yl)phenylimino]pentan-3-yl-idene}-2,6-bis-(propan-2-yl)aniline, [ArN=C(Me)-(Et)C=NAr] [Ar = 2,6-(iPr)2C6H3], (I), and the corresponding palladium complex, cis-(N-{2-[2,6-bis-(propan-2-yl)phenylimino]pentan-3-yl-idene}-2,6-bis-(propan-2-yl)aniline)di-chlor-ido-palladium(II) 1,2-di-chloro-ethane monosolvate, [PdCl2(C29H42N2)]·C2H4Cl2 or cis[PdCl2{I}], (II), have been synthesized and characterized. The crystal and mol-ecular structure of the palladium(II) complex have been established by single-crystal X-ray diffraction...
July 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28931531/clinical-and-cost-effectiveness-of-the-lightning-process-in-addition-to-specialist-medical-care-for-paediatric-chronic-fatigue-syndrome-randomised-controlled-trial
#10
Esther M Crawley, Daisy M Gaunt, Kirsty Garfield, William Hollingworth, Jonathan A C Sterne, Lucy Beasant, Simon M Collin, Nicola Mills, Alan A Montgomery
OBJECTIVE: Investigate the effectiveness and cost-effectiveness of the Lightning Process (LP) in addition to specialist medical care (SMC) compared with SMC alone, for children with chronic fatigue syndrome (CFS)/myalgic encephalitis (ME). DESIGN: Pragmatic randomised controlled open trial. Participants were randomly assigned to SMC or SMC+LP. Randomisation was minimised by age and gender. SETTING: Specialist paediatric CFS/ME service. PATIENTS: 12-18 year olds with mild/moderate CFS/ME...
September 20, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28931295/-two-year-follow-up-results-of-patients-with-macular-oedema-due-to-retinal-vein-occlusion-treated-with-ranibizumab
#11
Z Hladíková, E Klofáčová, B Kalvodová
PURPOSE: To evaluate 2-year follow-up results of patients with macular oedema (ME) caused by central (CRVO) and branch (BRVO) retinal vein occlusion treated with intravitreal ranibizumab at the Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic. METHODS: Retrospective study. RESULTS: The 2-year follow-up was completed by 18 patients with ME caused by CRVO and 16 patients with ME caused by BRVO...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28931044/the-performance-of-a-new-local-false-discovery-rate-method-on-tests-of-association-between-coronary-artery-disease-cad-and-genome-wide-genetic-variants
#12
Shuyan Mei, Ali Karimnezhad, Marie Forest, David R Bickel, Celia M T Greenwood
The maximum entropy (ME) method is a recently-developed approach for estimating local false discovery rates (LFDR) that incorporates external information allowing assignment of a subset of tests to a category with a different prior probability of following the null hypothesis. Using this ME method, we have reanalyzed the findings from a recent large genome-wide association study of coronary artery disease (CAD), incorporating biologic annotations. Our revised LFDR estimates show many large reductions in LFDR, particularly among the genetic variants belonging to annotation categories that were known to be of particular interest for CAD...
2017: PloS One
https://www.readbyqxmd.com/read/28930795/meet-me-in-the-nasal-vestibule-a-view-from-here
#13
Leanne Richbourg
No abstract text is available yet for this article.
September 19, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28930705/how-we-become-who-we-are-ashley-carla-and-the-rest-of-us
#14
Jamie Lindemann Nelson
Lisa Freitag and Joan Liaschenko's thoughtful and important article goes directly to the under-examined heart of Ashley's case, namely to what sustains her in a habitable and intelligible identity. Though quite sympathetic with their conclusion and line of argument, I try to trouble their proceedings a bit, largely by wondering how having a specific such identity, out of several that may be in-principle available, matters to someone with Ashley's cognitive scope. I do this not simply to be contrary, but because their article also seems to me to raise issues in the ethics of bioethics-in particular, what I call the dilemma of ethical endeavor: How ought one publicly pursue deeply important and complex issues, the very raising of which may offend interlocutors who indeed have grounds for resentment...
2017: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/28929805/-it-feels-like-something-difficult-is-coming-back-to-haunt-me-an-exploration-of-meltdowns-associated-with-autistic-spectrum-disorder-from-a-parental-perspective
#15
Indiana Montaque, Rudi Dallos, Becky McKenzie
The research explored the experience and understandings expressed by parents of children with autism concerning 'meltdowns', which are commonly described as distressing, escalating episodes of conflicts. Semi-structured interviews were conducted with six parents of children with a diagnosis of autism regarding their experience of 'meltdowns'. Parents were asked to track the process of the meltdowns as well as to describe their experiences. Three over-arching themes emerged which encapsulated their experience: Living in Dread: Anxiety and fear of escalating patterns, Attempting to Correct for Negative Childhood Experiences and Condemnation from the Self and Others...
September 1, 2017: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/28928789/the-long-term-course-of-outcomes-for-lumbar-intervertebral-disc-herniation-following-integrated-complementary-and-alternative-medicine-inpatient-treatment-a-prospective-observational-study
#16
Moon-Hwi Kim, Yoon Jae Lee, Joon-Shik Shin, Jinho Lee, Haechan Jeong, Me-Riong Kim, Sam-Min Park, Ung Go, Sung-Moon Kim, Jae-Yeong Kim, Dong-Gyu Hwang, In-Hyuk Ha
A prospective observational study was conducted in 524 lumbar intervertebral disc herniation (LDH) inpatients to report the long-term effects of complementary and alternative medicine (CAM) treatment. Participants received integrative CAM treatment during hospitalization, from June 2012 to May 2013, and long-term outcomes were assessed from July to August 2016. Numerical rating scales (NRSs) of back and leg pain, the Oswestry disability index (ODI), satisfaction, surgery, recurrence, and current care status were investigated...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28928350/does-the-early-adopter-catch-the-worm-or-choke-on-it-a-reflective-journey-of-the-challenges-of-technology-adoption-in-a-health-sciences-education-institution
#17
Chrisna Botha-Ravyse, Seugnet Blignaut
BACKGROUND: Early adoption of technology is a struggle well known to early adopters and now to me. Since the demand to use and implement technology in health professions' education has increased, I have been led to adopt various technologies, leading to many headaches. METHODS: This paper addresses my experiences in developing and implementing technology in health science classrooms in a setting not adequately equipped to do so. RESULTS: After reflecting on my experiences, I conclude that it is crucial that systems help innovators and early adopters as they work to develop and implement teaching and learning technology...
May 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28927955/modified-hybrid-fixation-using-absorbable-plate-and-screw-for-mandibular-advancement-surgery
#18
Koichiro Ueki, Kunio Yoshizawa, Akinori Moroi, Asami Hotta, Takamitsu Tsutsui, Kenichi Fukaya, Ryota Hiraide, Akihiro Takayama, Tatsuya Tsunoda, Yuki Saito, Nana Baba, Momoko Sato
PURPOSE: The purpose of this study was to examine the skeletal stability of mandibular advancement after sagittal split ramus osteotomy (SSRO) with modified hybrid fixation using absorbable plates and screws. MATERIALS AND METHODS: A total of 54 Japanese patients were enrolled in this study. Of them, 23 who were diagnosed with mandibular prognathism underwent setback surgery with bi-cortical plate fixation using absorbable plates and screws (setback group). Another 23 who were diagnosed with mandibular retrognathism underwent advancement surgery with modified hybrid fixation using absorbable plates (advance group), and 8 who were diagnosed with mandibular retrognathism underwent advancement surgery with titanium plates (titanium group)...
August 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28926187/synthesis-of-a-metallo-iminosilane-via-a-silanone-metal-%C3%AF-complex
#19
Matthias Driess, Terrance J Hadlington, Tibor Szilvási
Facile oxygenation of the acyclic amido chlorosilylene-bis(N-heterocyclic carbene) Ni0 complex 1, [{N(Dipp)(SiMe3)ClSi:→Ni(NHC)2] (Dipp = 2,6-Pri2C6H4; N-heterocyclic carbene = C[(Pri)NC(Me)]2) with N2O furnishes the first Si-metallo-iminosilane complex, [DippN=Si(OSiMe3)Ni(Cl)(NHC)2] 3, in a cascade of rearrangement reactions. Markedly, the formation of 3 ensues via a silanone (Si=O)-Ni pi-complex 2 as the initial product, which has been predicted by DFT calculations and could be observed spectroscopically...
September 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28924193/rational-development-of-catalytic-au-i-au-iii-arylation-involving-mild-oxidative-addition-of-aryl-halides
#20
Abdallah Zeineddine, Laura Estévez, Sonia Mallet-Ladeira, Karinne Miqueu, Abderrahmane Amgoune, Didier Bourissou
The reluctance of gold to achieve oxidative addition reaction is considered as an intrinsic limitation for the development of gold-catalyzed cross-coupling reactions with simple and ubiquitous aryl halide electrophiles. Here, we report the rational construction of a Au(I)/Au(III) catalytic cycle involving a sequence of Csp(2)-X oxidative addition, Csp(2)-H auration and reductive elimination, allowing a gold-catalyzed direct arylation of arenes with aryl halides. Key to this discovery is the use of Me-Dalphos, a simple ancillary (P,N) ligand, that allows the bottleneck oxidative addition of aryl iodides and bromides to readily proceed under mild conditions...
September 18, 2017: Nature Communications
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