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Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Faisal Thayyullathil
Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are increasingly being appreciated as powerful signaling molecules involved in the regulation of a variety of biological processes. Indeed, their role is continuously being delineated in a variety of pathophysiological conditions. For instance, cancer cells are shown to have increased ROS levels in comparison to their normal counterparts. This is partly due to an enhanced metabolism and mitochondrial dysfunction in cancer cells. The escalated ROS generation in cancer cells contributes to the biochemical and molecular changes necessary for the tumor initiation, promotion and progression, as well as, tumor resistance to chemotherapy...
January 11, 2017: Free Radical Biology & Medicine
Andreas Åvitsland, Ane Kristiansen Solbraa, Amund Riiser
BACKGROUND: Stair climbing is a vigorous activity and can lead to several health benefits. Studies seeking to increase stair climbing in various public locations have shown positive effects, while results from similar studies conducted in the workplace are inconclusive. This study examined stair climbing in the workplace, and monitored effects from a single- and a combined intervention. Interventions were inspired by nudging, the libertarian method of influencing behavior. METHODS: By quasi-experimental design, stair- and elevator traffic in two office buildings was monitored preceding-, during- and following interventions with stair leading footprints alone, and combined with stair-riser banners...
2017: Archives of Public Health, Archives Belges de Santé Publique
Vu An Do, Sofie Biering-Sørensen, Ane Bærent Fisker, Carlito Balé, Stine Møller Rasmussen, Lone Damkjær Christensen, Kristoffer Jarlov Jensen, Cesário Martins, Peter Aaby, Christine Stabell Benn
BACKGROUND:  Children in Guinea-Bissau receive measles vaccine (MV) at 9 months of age, but studies have shown that an additional dose before 9 months of age might have beneficial nonspecific effects. Within a randomized trial designed to examine nonspecific effects of early MV receipt on mortality, we conducted a substudy to investigate the effect of early MV receipt on morbidity. METHODS:  Children were randomly assigned at a ratio of 2:1 to receive 2 doses of MV at 18 weeks and age 9 months (intervention group) or 1 dose of MV at age 9 months, in accordance with current practice (control group)...
January 10, 2017: Journal of Infectious Diseases
D Lacerenza, S Aneli, C Di Gaetano, R Critelli, A Piazza, G Matullo, C Culigioni, R Robledo, C Robino, C Calò
Y-chromosomal variation of selected single nucleotide polymorphisms (SNPs) and 32 short tandem repeat (STR) loci was evaluated in Sardinia in three open population groups (Northern Sardinia, n=40; Central Sardinia, n=56; Southern Sardinia, n=91) and three isolates (Desulo, n=34; Benetutti, n=45, Carloforte, n=42). The tested Y-STRs consisted of Yfiler(®) Plus markers and the seven rapidly mutating (RM) loci not included in the YFiler(®) Plus kit (DYF399S1, DYF403S1ab, DYF404S1, DYS526ab, DYS547, DYS612, and DYS626)...
December 28, 2016: Forensic Science International. Genetics
Tiffany A Johnson, Susan Cooper, Greta C Stamper, Mark Chertoff
BACKGROUND: Exposure to both occupational and nonoccupational noise is recognized as a risk factor for noise-induced hearing loss (NIHL). Although audiologists routinely inquire regarding history of noise exposure, there are limited tools available for quantifying this history or for identifying those individuals who are at highest risk for NIHL. Identifying those at highest risk would allow hearing conservation activities to be focused on those individuals. PURPOSE: To develop a detailed, task-based questionnaire for quantifying an individual's annual noise exposure (ANE) arising from both occupational and nonoccupational sources (aim 1) and to develop a short screening tool that could be used to identify individuals at high risk of NIHL (aim 2)...
January 2017: Journal of the American Academy of Audiology
Mariela Dore, Paloma Triana Junco, Ane Andres Moreno, Vanesa Nuñez Cerezo, Martha Romo Muñoz, Alba Sánchez Galán, Alejandra Vilanova Sánchez, Gerardo Prieto, Esther Ramos, Francisco Hernandez, Leopoldo Martínez Martínez, Manuel Lopez Santamaria
Aim Short bowel syndrome (SBS) is the leading cause of intestinal failure (IF) in the pediatric population. Our aim was to review long-term outcome of ultrashort bowel syndrome (USBS) in an Intestinal Rehabilitation Unit (IRU). Patients and Methods Retrospective study of patients with USBS (defined as < 10 cm of remnant small bowel) treated between 2000 and 2015. Demographic data, clinical, and treatment variables including parenteral nutrition (PN), surgical techniques, and intestinal transplantation (IT) were analyzed...
January 4, 2017: European Journal of Pediatric Surgery
Palapuravan Anees, Karivachery V Sudheesh, Purushothaman Jayamurthy, Arunkumar R Chandrika, Ramakrishnapillai V Omkumar, Ayyappanpillai Ajayaghosh
Accurate monitoring of pH variations inside cells is important for the early diagnosis of diseases such as cancer. Even though a variety of different pH sensors are available, construction of a custom-made sensor array for measuring minute variations in a narrow biological pH window, using easily available constituents, is a challenge. Here we report two-component hybrid sensors derived from a protein and organic dye nanoparticles whose sensitivity range can be tuned by choosing different ratios of the components, to monitor the minute pH variations in a given system...
November 18, 2016: Chemical Science
Philip H Quanjer, Gregg L Ruppel, Arnulf Langhammer, Abhishek Krishna, Frans Mertens, Ane Johannessen, Ana M B Menezes, Fernando C Wehrmeister, Rogelio Perez-Padilla, Maureen P Swanney, Wan C Tan, Jean Bourbeau
BACKGROUND: Recommendations on interpreting tests of bronchodilator responsiveness (BDR) are conflicting. We investigated the dependence of BDR criteria on sex, age, height, ethnicity and severity of respiratory impairment. METHODS: BDR tests were available from clinical patients in the Netherlands, New Zealand and the USA (N=15,278, 51.7% females) and surveys in Canada, Norway and five Latin-American countries (N=16,250, 54.7% females). BDR in FEV1, FVC and FEV1/ FVC was expressed as absolute change, % baseline, % predicted and z-score...
December 28, 2016: Chest
Ane Nørgaard, Christina Jensen-Dahm, Christiane Gasse, Elsebet Steno Hansen, Gunhild Waldemar
BACKGROUND: Antipsychotics and other psychotropics are frequently used to treat neuropsychiatric symptoms in patients with dementia, even though the evidence for effect is limited. Concerns have been raised about the safety of antipsychotics, but concomitant use of multiple psychotropic drug classes (psychotropic polypharmacy) may also pose a risk for patients. OBJECTIVE: To investigate the prevalence and predictors associated with use of psychotropic polypharmacy in patients with dementia...
December 30, 2016: Journal of Alzheimer's Disease: JAD
Krishna Kumar Mohanan Nair, Narayanan Namboodiri, Bharatraj Banavalikar, Sreevilasam Pushpangadhan Abhilash, Anees Thajudeen, Ajitkumar Valaparambil
No abstract text is available yet for this article.
November 16, 2016: Journal of Cardiovascular Electrophysiology
Yuee Li, Zhong Wang, Xijiao Mu, Aning Ma, Shu Guo
Optical labels are needed for probing specific target molecules in complex biological systems. As a newly emerging category of tags for molecular imaging in live cells, the Raman label attracts much attention because of the rich information obtained from targeted and untargeted molecules by detecting molecular vibrations. Here, we list three types of Raman probes based on different mechanisms: Surface Enhanced Raman Scattering (SERS) probes, bioorthogonal Raman probes, and Resonance Raman (RR) probes. We review how these Raman probes work for detecting and imaging proteins, nucleic acids, lipids, and other biomolecules in vitro, within cells, or in vivo...
December 23, 2016: Biotechnology Advances
Itxaso Azkune Calle, Jone Bocos Portillo, Ane Anton-Ladislao, Alberto Gil Garcia, Eva Gonzalez Diaz, Marian Gomez-Beldarrain, Covadonga Fernandez Maiztegi, Ana Pinedo Brochado, Juan Carlos Garcia-Monco
BACKGROUND: Endovascular revascularization with mechanical devices has proven an effective treatment for proximal occlusions of the major intracranial arteries in stroke patients, but there is only limited information as to whether there should be an age limit for its use. We aimed to evaluate the safety and effectiveness of endovascular revascularization in stroke patients aged 80 years and older, and compare the results with younger patients. METHODS: We prospectively collected 81 consecutive patients subjected to mechanical thrombectomy for proximal occlusion of the anterior circulation during a period of 27 months...
December 21, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Peter Aaby, Andreas Andersen, Cesário L Martins, Ane B Fisker, Amabelia Rodrigues, Hilton C Whittle, Christine S Benn
BACKGROUND: BCG and measles vaccine (MV) may have beneficial non-specific effects (NSEs). If an unplanned intervention with a vaccine (a natural experiment) modifies the estimated effect in a randomised controlled trial (RCT), this suggests NSEs. We used this approach to test NSEs of triple oral polio vaccine (OPV). METHODS: During an RCT of 2 doses of MV at 4.5 and 9 months versus 1 dose of MV at 9 months of age, we experienced 2 natural experiments with OPV...
December 23, 2016: BMJ Open
Yi-Jia Chen, Ssu-Yen Huang
The anomalous Nernst effect (ANE) and the spin Seebeck effect (SSE) in spin caloritronics are two of the most important mechanisms to manipulate the spin-polarized current and pure spin current by thermal excitation. While the ANE in ferromagnetic metals and the SSE in magnetic insulators have been extensively studied, a recent theoretical work suggests that the signals from the thermal Hall effect (THE) have field dependences indistinguishable from, and may even overwhelm, those of the ANE and SSE. Therefore, it is vital to investigate the contribution of the THE in the ANE and SSE...
December 9, 2016: Physical Review Letters
Siri L Rydning, Paul H Backe, Mirta M L Sousa, Zafar Iqbal, Ane-Marte Øye, Ying Sheng, Mingyi Yang, Xiaolin Lin, Geir Slupphaug, Tonje H Nordenmark, Magnus D Vigeland, Magnar Bjørås, Chantal M Tallaksen, Kaja K Selmer
Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 has been implicated in early-onset progressive neurodegeneration (MIM no. 615491), so far only in one family. In this study a second family is characterized, and the functional consequences of the identified mutations in UCHL1 are explored. Three siblings developed childhood-onset optic atrophy, followed by spasticity and ataxia. Whole exome sequencing identified compound heterozygous variants in UCHL1, c.533G>A (p.Arg178Gln) and c.647C>A (p...
December 22, 2016: Human Molecular Genetics
Ane Langkilde, Lene C Olsen, Pål Sætrom, Finn Drabløs, Søren Besenbacher, Line Raaby, Claus Johansen, Lars Iversen
Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a complex interplay between T cells, dendritic cells and the epidermis in which T cells and dendritic cells maintain skin inflammation. Anti-tumour necrosis factor (anti-TNF)-α agents have been approved for therapeutic use across a range of inflammatory disorders including psoriasis, but the anti-inflammatory mechanisms of anti-TNF-α in lesional psoriatic skin are not fully understood. We investigated early events in skin from psoriasis patients after treatment with anti-TNF-α antibodies by use of bioinformatics tools...
2016: PloS One
Amina Godinjak, Amer Iglica, Admir Rama, Ira Tančica, Selma Jusufović, Anes Ajanović, Adis Kukuljac
OBJECTIVE: The aim is to determine SAPS II and APACHE II scores in medical intensive care unit (MICU) patients, to compare them for prediction of patient outcome, and to compare with actual hospital mortality rates for different subgroups of patients. METHODS: One hundred and seventy-four patients were included in this analysis over a oneyear period in the MICU, Clinical Center, University of Sarajevo. The following patient data were obtained: demographics, admission diagnosis, SAPS II, APACHE II scores and final outcome...
November 2016: Acta Medica Academica
Md Jawaid Akhtar, Anees Ahmad Siddiqui, Ahsan Ahmed Khan, Zulphikar Ali, Rikeshwer Prasad Dewangan, Santosh Pasha, M Shahar Yar
The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied. Compounds 7a specifically inhibit EGFR and erbB2 receptor at 0.081 and 0.098 μM concentration. Some of the compounds showed strong, broad-spectrum antiproliferative activitiy when tested against five human cancer cell lines. Compounds 7a and 7n were more cytotoxic than 5-fluorouracil against MCF-7 cancer cell, with IC50 values of 5.0 and 2...
December 9, 2016: European Journal of Medicinal Chemistry
Rafia Shahzad, Abu Bakar Shahid, Zeeshan Rashid Mirza, Ayesha Anees
Developmental anomalies of the pancreas have been reported; but among these, agenesis of dorsal pancreas is an extremely rare congenital pancreatic anomaly. It may be asymptomatic and incidentally detected on imaging or may be associated with diabetes mellitus or attacks of pancreatitis. We report a rare case of agenesis of dorsal pancreas that was detected incidentally on imaging and there was no other co-existing anomaly.
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Hannah Copeland, Anees Razzouk, Allison Beckham, Richard Chinnock, Nahidh Hasaniya, Leonard Bailey
To evaluate social development of pediatric heart transplant (tx) recipients who have lived 15 or more years after transplantation. Among 498 pediatric patients, age less than 18 years, who underwent heart transplantation, at a single institution, 337 were performed between 1985 and 1998. We identified all who survived more than 15 years and engaged them in a survey regarding employment, education, marital, and social status. One hundred and eighty-three recipients (54.3%; 183/337) have survived greater than 15 years; of these, 150 (81...
December 15, 2016: Pediatric Transplantation
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