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https://www.readbyqxmd.com/read/28231325/cardiovascular-exercise-and-burden-of-arrhythmia-in-patients-with-atrial-fibrillation-a-randomized-controlled-trial
#1
Ane Katrine Skielboe, Thomas Quaade Bandholm, Stine Hakmann, Malene Mourier, Thomas Kallemose, Ulrik Dixen
BACKGROUND: Physical activity at moderate-high intensity is recommended to prevent lifestyle diseases. Patients with atrial fibrillation are at risk of a sedentary lifestyle due to fear of exercise-induced episodes of atrial fibrillation. The burden of arrhythmia can be reduced by physical exercise. The effect of exercise intensity on burden of atrial fibrillation needs to be studied further. METHODS AND RESULTS: In a 12-week randomized controlled trial, 76 patients with paroxysmal/persistent atrial fibrillation were allocated to perform exercise at either low intensity or high intensity (50% and 80% of maximal perceived exertion, respectively)...
2017: PloS One
https://www.readbyqxmd.com/read/28227772/the-chronnectome-evaluating-replicability-of-dynamic-connectivity-patterns-in-7500-resting-fmri-datasets
#2
Anees Abrol, Charlotte Chaze, Eswar Damaraju, Vince D Calhoun, Anees Abrol, Charlotte Chaze, Eswar Damaraju, Vince D Calhoun, Vince D Calhoun, Eswar Damaraju, Anees Abrol, Charlotte Chaze
Functional fMRI data are typically analyzed under the assumption that participants experience one long, continuous connectivity state throughout rest scan sessions. The chronnectome is a model that takes into account the temporal variance in connectivity throughout a scan session. In this work, we evaluate the repeatability of properties of functional network connectivity (FNC) dynamics assessed using sliding-windowed correlations in 28 independent age-matched large samples of 250 subjects. This approach revealed that multiple discrete, reoccurring connectivity states arise during rest, and that subjects tend to remain in one connectivity state for long periods of time before transitioning to another...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225166/journal-of-neuroscience-research-policy-on-addressing-sex-as-a-biological-variable-comments-clarifications-and-elaborations
#3
Gina Rippon, Rebecca Jordan-Young, Anelis Kaiser, Daphna Joel, Cordelia Fine
No abstract text is available yet for this article.
February 22, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28223362/mechanistic-insights-into-the-allosteric-regulation-of-bacterial-adp-glucose-pyrophosphorylases
#4
Natalia Comino, Javier Cifuente, Alberto Marina, Ane Orrantia, Ander Eguskiza, Marcelo E Guerin
ADP-glucose pyrophosphorylase (AGPase) controls bacterial glycogen and plant starch biosynthetic pathways, the most common carbon storage polysaccharides in nature. AGPase activity is allosterically regulated by a series of metabolites in the energetic flux within the cell. Very recently, we reported the first crystal structures of the paradigmatic AGPase from Escherichia coli (EcAGPase) in complex with its preferred physiological negative and positive allosteric regulators, adenosine-5'-monophosphate (AMP) and fructose-1,6-bisphosphate (FBP), respectively...
February 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28220328/the-provision-of-dietary-and-physical-activity-advice-for-men-diagnosed-with-prostate-cancer-a-qualitative-study-of-the-experiences-and-views-of-health-care-professionals-patients-and-partners
#5
Eileen Sutton, Lucy E Hackshaw-McGeagh, Jonathan Aning, Amit Bahl, Anthony Koupparis, Raj Persad, Richard M Martin, J Athene Lane
PURPOSE: To explore the views and experiences of health care professionals (HCPs), men diagnosed with localised prostate cancer and their partners about the provision of advice on diet and physical activity after diagnosis and treatment for localised prostate cancer. METHODS: Semi-structured in-depth interviews with ten HCPs (Consultant Urological Surgeons, Uro-Oncology Clinical Nurse Specialists and Allied Health Professionals: see Table 1) and sixteen men diagnosed with localised prostate cancer and seven of their partners...
February 20, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28220032/pharmacologic-blockade-of-%C3%AE-v%C3%AE-1-integrin-ameliorates-renal-failure-and-fibrosis-in-vivo
#6
Yongen Chang, Wei Ling Lau, Hyunil Jo, Kazuyuki Tsujino, Leslie Gewin, Nilgun Isik Reed, Amha Atakilit, Ane Claudia Fernandes Nunes, William F DeGrado, Dean Sheppard
Activated fibroblasts are deemed the main executors of organ fibrosis. However, regulation of the pathologic functions of these cells in vivo is poorly understood. PDGF receptor β (PDGFRβ) is highly expressed in activated pericytes, a main source of fibroblasts. Studies using a PDGFRβ promoter-driven Cre system to delete αv integrins in activated fibroblasts identified these integrins as core regulators of fibroblast activity across solid organs, including the kidneys. Here, we used the same PDGFRβ-Cre line to isolate and study renal fibroblasts ex vivo We found that renal fibroblasts express three αv integrins, namely αvβ1, αvβ3, and αvβ5...
February 20, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28218443/atrial-entrainment-during-posterior-fascicular-ventricular-tachycardia
#7
Krishna Kumar Mohanan Nair, Narayanan Namboodiri, Anees Thajudeen, Krishna Chaitanya, Sreevilasam Pushpangadhan Abhilash, Ajitkumar Valaparambil
A 20-year-old gentleman underwent electrophysiology study for paroxysmal palpitation. The surface electrocardiogram during sinus rhythm did not show any preexcitation. Echocardiogram was normal.  Basal intervals including AH and HV intervals were 115 ms and 42 ms, respectively. This article is protected by copyright. All rights reserved.
February 20, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28215921/role-of-myocardial-collagen-in-severe-aortic-stenosis-with-preserved-ejection-fraction-and-symptoms-of-heart-failure
#8
Kattalin Echegaray, Ion Andreu, Ane Lazkano, Iñaki Villanueva, Alberto Sáenz, María Reyes Elizalde, Tomás Echeverría, Begoña López, Asier Garro, Arantxa González, Elena Zubillaga, Itziar Solla, Iñaki Sanz, Jesús González, Alberto Elósegui-Artola, Pere Roca-Cusachs, Javier Díez, Susana Ravassa, Ramón Querejeta
INTRODUCTION AND OBJECTIVES: We investigated the anatomical localization, biomechanical properties, and molecular phenotype of myocardial collagen tissue in 40 patients with severe aortic stenosis with preserved ejection fraction and symptoms of heart failure. METHODS: Two transmural biopsies were taken from the left ventricular free wall. Mysial and nonmysial regions of the collagen network were analyzed. Myocardial collagen volume fraction (CVF) was measured by picrosirius red staining...
February 16, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28215601/design-and-synthesis-of-quinazoline-3-4-4h-diamine-endowed-with-thiazoline-moiety-as-new-class-for-dpp-4-and-dpph-inhibitor
#9
Zulphikar Ali, Md Jawaid Akhtar, Md Rafi Haider, Ahsan Ahmed Khan, Anees Ahmad Siddiqui, M Shahar Yar
New N3-benzylidene (substituted)-2-phenyl-N4-(thiazol-2-yl)-quinazoline-3,4-(4H)-diamine derivatives were design and synthesized by a sequence of reactions starting from appropriate 6-methyl anthranilic acid. The title compounds were screened for in vitro dipeptidyl peptidase IV (DPP-4) inhibitory activity and diphenyl-2-picryl-hydrazyl (DPPH) assay and results showed significant to good activity in compared to Linagliptin for antidiabetic activity and Ascorbic acid for antioxidant activity. Compound 7g (IC50=0...
February 10, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28215167/chemical-modifications-of-ketoprofen-nsaid-in-search-of-better-lead-compounds-a-review-of-literature-from-2004-2016
#10
Gita Chawla, Chanda Ranjan, Anees A Siddiqui, Jagdish Kumar, Ankita Pathak
BACKGROUND: Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug belonging to the propionic acid class was synthesized in 1968. Rapid absorption, simple metabolism, faster blood brain barrier crossing and high antinociceptive activity are the features responsible for its high use. But, free acidic moiety present in its structure is the major factor that declines its popularity by causing various gastric side effects .Many researchers have chemically modified this drug with the aim to discover an improved and safe NSAID candidate or a new drug with altered activity...
February 16, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28212950/incorporating-budget-impact-analysis-in-the-implementation-of-complex-interventions-a-case-of-an-integrated-intervention-for-multimorbid-patients-within-the-carewell-study
#11
Myriam Soto-Gordoa, Arantzazu Arrospide, Marisa Merino Hernández, Joana Mora Amengual, Ane Fullaondo Zabala, Igor Larrañaga, Esteban de Manuel, Javier Mar
OBJECTIVES: To develop a framework for the management of complex health care interventions within the Deming continuous improvement cycle and to test the framework in the case of an integrated intervention for multimorbid patients in the Basque Country within the CareWell project. METHODS: Statistical analysis alone, although necessary, may not always represent the practical significance of the intervention. Thus, to ascertain the true economic impact of the intervention, the statistical results can be integrated into the budget impact analysis...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212023/electrostatic-assembly-of-functional-and-macromolecular-ferricinium-chloride-stabilized-gold-nanoparticles
#12
Roberto Ciganda, Haibin Gu, Ricardo Hernandez, Ane Escobar, Angel Martínez, Luis Yates, Sergio Moya, Jaime Ruiz, Didier Astruc
Substituted ferrocenes with various stereoelectronic effects including a ferrocene-terminated dendrimer in ether reduce aqueous HAuCl4 to gold nanoparticles (AuNPs) by interfacial electron transfer. The dependence on the stirring speed plays a crucial role, and the stereoelectronic influences on the reaction rates are dramatic. With a ferrocene-containing polymer, the reaction is conducted using an homogeneous THF/water medium, also forming AuNPs. Fully stable functional, dendritic and polymeric ferricinium chloride-stabilized AuNPs are obtained with core sizes between 13 and 35 nm, an optimal size range for potential biomedical applications...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28210323/how-to-keep-good-clinical-records
#13
Alexander Mathioudakis, Ilona Rousalova, Ane Aamli Gagnat, Neil Saad, Georgia Hardavella
Clinical record keeping is integral to good professional practice and the delivery of quality healthcare http://ow.ly/TicN305wiyc.
December 2016: Breathe
https://www.readbyqxmd.com/read/28210314/how-to-prepare-for-an-interview
#14
Georgia Hardavella, Ane Aamli Gagnat, Daniela Xhamalaj, Neil Saad
How to prepare for an interview; this is your moment to shine and turn it into a successful experience! http://ow.ly/Wv0y302E8Fd.
September 2016: Breathe
https://www.readbyqxmd.com/read/28209405/insights-of-pb-isotopic-signature-into-the-historical-evolution-and-sources-of-pb-contamination-in-a-sediment-core-of-the-southwestern-iberian-atlantic-shelf
#15
Mário Mil-Homens, Carlos Vale, Pedro Brito, Filipa Naughton, Teresa Drago, Joana Raimundo, Bárbara Anes, Sabine Schmidt, Miguel Caetano
Stable Pb isotopic ratios and concentrations of Al, Cu and Pb were measured in a 5m long sediment core (VC2B) retrieved at 96m water depth in the southwestern Iberian Atlantic shelf. Five phases during the last 9.5kyrs were identified, two of them (Roman Period and modern mining) marked by a decrease of (206)Pb/(207)Pb ratios reflecting additional inputs of Pb derived from mining activities. The Roman Period was also characterized by high (208)Pb/(206)Pb ratios suggesting the exploitation of the outcropping portion of the orebody intensely weathered when compared with the other formations later mined...
February 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28207173/sensitivity-analysis-of-effective-population-size-to-demographic-parameters-in-house-sparrow-populations
#16
Marlene Waege Stubberud, Ane Marlene Myhre, Håkon Holand, Thomas Kvalnes, Thor Harald Ringsby, Bernt-Erik Saether, Henrik Jensen
The ratio between the effective and the census population size, Ne/N, is an important measure of the long-term viability and sustainability of a population. Understanding which demographic processes that affect Ne/N most will improve our understanding of how genetic drift and the probability of fixation of alleles is affected by demography. This knowledge may also be of vital importance in management of endangered populations and species. Here, we use data from 13 natural populations of house sparrow (Passer domesticus) in Norway to calculate the demographic parameters that determine Ne/N...
February 16, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28202049/costs-and-benefits-of-natural-transformation-in-acinetobacter-baylyi
#17
Nils Hülter, Vidar Sørum, Kristina Borch-Pedersen, Mikkel M Liljegren, Ane L G Utnes, Raul Primicerio, Klaus Harms, Pål J Johnsen
BACKGROUND: Natural transformation enables acquisition of adaptive traits and drives genome evolution in prokaryotes. Yet, the selective forces responsible for the evolution and maintenance of natural transformation remain elusive since taken-up DNA has also been hypothesized to provide benefits such as nutrients or templates for DNA repair to individual cells. RESULTS: We investigated the immediate effects of DNA uptake and recombination on the naturally competent bacterium Acinetobacter baylyi in both benign and genotoxic conditions...
February 15, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28199764/clinical-markers-of-asthma-and-ige-assessed-in-parents-before-conception-predicts-asthma-and-hay-fever-in-the-offspring
#18
Randi J Bertelsen, Marta Rava, Anne Elie Carsin, Simone Accordini, Bryndis Benediktsdóttir, Julia Dratva, Karl A Franklin, Joachim Heinrich, Mathias Holm, Christer Janson, Ane Johannessen, Deborah L Jarvis, Rain Jogi, Benedicte Leynaert, Dan Norback, Ernst Reidar Omenaas, Chantal Raherison, José Luis Sánchez-Ramos, Vivi Schlünssen, Torben Sigsgaard, Shyamali C Dharmage, Cecilie Svanes
BACKGROUND: Mice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans. OBJECTIVE: We aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness (BHR), and total and specific IgEs, measured before conception vs after birth, with offspring asthma and hay fever. METHODS: The study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey (ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991-1993, and data on 9100 offspring born 1972-2012...
February 15, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28199701/hepatitis-e-virus-infects-neurons-and-brains
#19
Xinying Zhou, Fen Huang, Lei Xu, Zhanmin Lin, Femke M S de Vrij, Ane C Ayo-Martin, Mark van der Kroeg, Manzhi Zhao, Yuebang Yin, Wenshi Wang, Wanlu Cao, Yijin Wang, Steven A Kushner, Jean Marie Peron, Laurent Alric, Robert A de Man, Bart C Jacobs, Jeroen J van Eijk, Eleonora M A Aronica, Dave Sprengers, Herold J Metselaar, Chris I de Zeeuw, Harry R Dalton, Nassim Kamar, Maikel P Peppelenbosch, Qiuwei Pan
No abstract text is available yet for this article.
February 11, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28196946/individualised-risk-assessment-for-local-recurrence-and-distant-metastases-in-a-retrospective-transatlantic-cohort-of-687-patients-with-high-grade-soft-tissue-sarcomas-of-the-extremities-a-multistate-model
#20
Julie J Willeumier, Anja J Rueten-Budde, Lee M Jeys, Minna Laitinen, Rob Pollock, Will Aston, P D Sander Dijkstra, Peter C Ferguson, Anthony M Griffin, Jay S Wunder, Marta Fiocco, Michiel A J van de Sande
OBJECTIVES: This study investigates the effect of surgical margins and radiotherapy, in the presence of individual baseline characteristics, on survival in a large population of high-grade soft tissue sarcoma of the extremities using a multistate model. DESIGN: A retrospective multicentre cohort study. SETTING: 4 tertiary referral centres for orthopaedic oncology. PARTICIPANTS: 687 patients with primary, non-disseminated, high-grade sarcoma only, receiving surgical treatment with curative intent between 2000 and 2010 were included...
February 14, 2017: BMJ Open
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