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https://www.readbyqxmd.com/read/29775797/functional-screening-of-selective-mitochondrial-inhibitors-of-plasmodium
#1
Maria G Gomez-Lorenzo, Ane Rodríguez-Alejandre, Sonia Moliner-Cubel, María Martínez-Hoyos, Noemí Bahamontes-Rosa, Rubén Gonzalez Del Rio, Carolina Ródenas, Jesús de la Fuente, Jose Luis Lavandera, Jose F García-Bustos, Alfonso Mendoza-Losana
Phenotypic screening has produced most of the new chemical entities currently in clinical development for malaria, plus many lead compounds active against Plasmodium falciparum asexual stages. However, lack of knowledge about the mode of action of these compounds delays and may even hamper their future development. Identifying the mode of action of the inhibitors greatly helps to prioritise compounds for further development as novel antimalarials. Here we describe a whole-cell method to detect inhibitors of the mitochondrial electron transport chain, using oxygen consumption as high throughput readout in 384-well plate format...
May 9, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29774173/role-of-interventional-radiology-in-the-management-of-peripheral-vascular-malformations-a-tertiary-care-center-experience
#2
Misbah Tahir, Muhammad Anees Mumtaz, Anum Sultan, Jawaid Iqbal, Raza Sayani
Peripheral vascular malformations (PVMs) represent a wide spectrum of vascular abnormalities occurring due to anomalous connections between arteries, veins, capillaries, and lymphatic channels at the microscopic level, in different combinations. They are rare and challenging to treat. Different operators may have different approaches based on their experience and expertise. Sclerotherapy either alone or in combination with embolization has been used as an independent method for the treatment of PVMs. Purpose The aim of this study is to assess the safety and efficacy of sclerotherapy and embolization, with or without surgery, for the treatment of peripheral vascular malformations, based on our approach...
March 16, 2018: Curēus
https://www.readbyqxmd.com/read/29751899/determination-of-food-colorants-in-a-wide-variety-of-food-matrices-by-microemulsion-electrokinetic-capillary-chromatography-considerations-on-the-found-concentrations-and-regulated-consumption-limits
#3
Ane Bordagaray, Rosa Garcia-Arrona, Maider Vidal, Miren Ostra
Color additives are used widely by the food industry to confer a desirable appearance. Some of the most used colorants (Tartrazine (E102), Sunset Yellow (E110), Red Allure (E129) and Blue Brilliant (E133)) were determined in this study using microemulsion electrokinetic capillary chromatography (MEEKC). Regression coefficients were greater than 0.9981; intra- and inter-day precisions, in terms of percentage RSD, were less than 7.01% and 8.55%, respectively; recoveries were between 90 and 100% in most cases...
October 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29749754/predictors-of-mortality-during-hospitalization-and-3-months-after-discharge-in-elderly-people-with-and-without-dementia
#4
Josune Martín, Angel Padierna, Ane Anton-Ladislao, Inmaculada Moro, José M Quintana
OBJECTIVES: The aims of this study were to assess mortality during hospitalization and 3 months after discharge in elderly people with and without dementia, and to identify variables that might predict mortality. METHODS: A prospective matched cohort study was conducted involving 195 inpatients with dementia and 204 inpatients without dementia. Information on sociodemographic, and clinical data were gathered. Patients completed questionnaires on premorbid basic (Barthel, BI) and instrumental activities of daily living (Lawton and Brody), quality of life (EuroQoL5-D; Quality of Life in Alzheimer's Disease), burden of the caregiver (Zarit)...
May 11, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29748032/selecting-the-right-indicators-to-ensure-optimised-implementation-of-bcg-vaccination-policy
#5
Sanne Marie Thysen, Ane Bærent Fisker
No abstract text is available yet for this article.
May 7, 2018: Vaccine
https://www.readbyqxmd.com/read/29745479/predictors-of-one-and-two-year-mortality-in-patients-with-rectal-cancer
#6
José M Quintana, Nerea González, Santiago Lázaro, Marisa Baré, Nerea Fernandez de Larrea, Maximino Redondo, Eduardo Briones, Antonio Escobar, Cristina Sarasqueta, Susana García-Gutierrez, Ane Antón-Ladislao
AIM: Tools are needed to aid in the assessment of prognosis of patients with rectal cancer regarding the risk of medium-term mortality. The aim of this study was to develop and validate clinical prediction rules for 1- and 2-year mortality in patients undergoing surgery for rectal cancer. METHOD: A prospective cohort study of patients diagnosed with rectal cancer who underwent surgery was carried out. The main outcomes were mortality at 1 and 2 years after surgery...
May 10, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29741717/influenza-associated-acute-necrotizing-encephalopathy-in-siblings
#7
Ashley Howard, Timothy M Uyeki, Jaime Fergie
Encephalopathy is an important complication associated with influenza, most frequently observed in young children, with a wide range of severity. The most severe category of influenza-associated encephalopathy (IAE) is acute necrotizing encephalopathy (ANE), characterized by high frequency of neurologic sequelae and fatal outcomes. We report two young siblings who developed fever and seizures with altered mental status. Influenza A(H1N1)pdm09 virus infection was identified in upper respiratory tract specimens from both patients, and neuroimaging revealed bilateral inflammatory lesions, consistent with acute necrotizing encephalopathy...
May 4, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29736620/cardioprotective-effect-of-zingerone-against-oxidative-stress-inflammation-and-apoptosis-induced-by-cisplatin-or-gamma-radiation-in-rats
#8
Ahmed F Soliman, Lobna M Anees, Doaa M Ibrahim
Despite their clinical benefits in cancer treatment, the deleterious effects on heart following chemo/radiotherapy are of increasing importance. Zingerone, a natural polyphenol, possesses multiple biological activities, such as antioxidant and anti-inflammatory. Thus, the current study was designed to assess the potential cardioprotective effects of zingerone against cisplatin or γ-radiation. Zingerone was given by intragastric intubation (25 mg/kg) daily for three successive weeks prior to the induction of cardiotoxicity using a single dose of cisplatin (20 mg/kg, i...
May 7, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29733209/nitrogen-and-phosphorus-removal-from-agricultural-runoff-in-integrated-buffer-zones
#9
Dominik Zak, Brian Kronvang, Mette Vodder Carstensen, Carl Christian Hoffmann, Ane Kjeldgaard, Soren Erik Larsen, Joachim Audet, Sara Egemose, Charlotte Adam Jørgensen, Peter Feuerbach, Flemming Gertz, Henning Jensen
Integrated buffer zones (IBZs) represent a novel form of edge-of-field technology in Northwest Europe. Contrary to the common riparian buffer strips, IBZs collect tile drainage water from agricultural fields by combining a ditch-like pond (POND), where soil particles can settle, and a flow-through filter bed (FILTERBED) planted with Alnus glutinosa (L.), a European alder (black alder). The first experimental IBZ facility was constructed and thoroughly tested in Denmark for its capability to retain various nitrogen (N) and phosphorus (P) species within the first three years after construction...
May 7, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29732366/importance-of-comprehensive-molecular-profiling-for-clinical-outcome-in-children-with-recurrent-cancer
#10
Olga Østrup, Karsten Nysom, David Scheie, Ane Y Schmidt, Rene Mathiasen, Lisa L Hjalgrim, Tina E Olsen, Jane Skjøth-Rasmussen, Birthe M Henriksen, Finn C Nielsen, Peder S Wehner, Henrik Schrøder, Astrid M Sehested, Catherine Rechnitzer, Maria Rossing
Purpose: Pediatric cancers are often difficult to classify and can be complex to treat. To ensure precise diagnostics and identify relevant treatment targets, we implemented comprehensive molecular profiling of consecutive pediatric patients with cancer relapse. We evaluated the clinical impact of extensive molecular profiling by assessing the frequency of identified biological onco-drivers, altered diagnosis, and/or identification of new relevant targeted therapies. Patients and Methods: Forty-six tumor samples (44 fresh-frozen; two formalin-fixed paraffin embedded), two bone marrow aspirates, three cerebrospinal fluid samples, and one archived DNA were obtained from 48 children (0-17 years; median 9...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29725986/efficacy-and-safety-of-analgesic-treatment-for-depression-in-people-with-advanced-dementia-randomised-multicentre-double-blind-placebo-controlled-trial-dep-pain-dem
#11
Ane Erdal, Elisabeth Flo, Dag Aarsland, Clive Ballard, Dagrun D Slettebo, Bettina S Husebo
BACKGROUND: Chronic pain and depression often co-occur, and pain may exacerbate depression in people with dementia. OBJECTIVE: The objective of this study was to assess the efficacy and safety of analgesic treatment for depression in nursing home patients with advanced dementia and clinically significant depressive symptoms. METHODS: We conducted a multicentre, parallel-group, double-blind, placebo-controlled trial in 47 nursing homes, including 162 nursing home patients aged ≥ 60 years with dementia (Mini-Mental State Examination ≤ 20) and depression (Cornell Scale for Depression in Dementia ≥ 8)...
May 3, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29723619/carboxymethyl-assam-bora-rice-starch-coated-spions-synthesis-characterization-and-in-vitro-localization-in-a-micro-capillary-for-simulating-a-targeted-drug-delivery-system
#12
Sharmistha Mohapatra, Mohammed Asfer, Mohammed Anwar, Shakeeb Ahmed, Farhan J Ahmad, Anees A Siddiqui
Carboxymethyl Assam Bora rice starch coated superparamagnetic iron oxide nanoparticles (CM-ABRS SPIONs) were chemically synthesized by co-precipitation method and particle size reduction was controlled by high energy homogenization process. Effects of various process variables (polymer concentration, homogenization speed and cycles) were optimized on the basis of average particle size (Z-average) and polydispersity index (PDI) of CM-ABRS SPIONs. The optimized CM-ABRS SPIONs were characterized for their particle size, surface morphology, electrokinetic potential, chemical interactions, crystallinity, magnetic properties, and targeting potential in presence of external magnetic field...
April 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29723414/fast-reactivation-of-photosynthesis-in-arctic-phytoplankton-during-the-polar-night
#13
Ane Cecilie Kvernvik, Clara Jule Marie Hoppe, Evelyn Lawrenz, Ondřej Prášil, Michael Greenacre, Józef Maria Wiktor, Eva Leu
Arctic microalgae experience long periods of continuous darkness during the polar night, where they are unable to photosynthesize. Despite numerous studies on overwintering strategies, such as utilization of stored energy products, formation of resting stages, reduction of metabolic rate and heterotrophic lifestyles, there have been few attempts to assess the in situ physiological state and restoration of the photosynthetic apparatus upon re-illumination. In this study, we found diverse and active marine phytoplankton communities during the polar night at 78° N...
May 3, 2018: Journal of Phycology
https://www.readbyqxmd.com/read/29720562/airway-responsiveness-to-methacholine-and-incidence-of-copd-an-international-prospective-cohort-study
#14
Alessandro Marcon, Francesca Locatelli, Dirk Keidel, Anna B Beckmeyer-Borowko, Isa Cerveri, Shyamali C Dharmage, Elaine Fuertes, Judith Garcia-Aymerich, Joachim Heinrich, Medea Imboden, Christer Janson, Ane Johannessen, Bénédicte Leynaert, Silvia Pascual Erquicia, Giancarlo Pesce, Emmanuel Schaffner, Cecilie Svanes, Isabel Urrutia, Deborah Jarvis, Nicole M Probst-Hensch, Simone Accordini
BACKGROUND: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. OBJECTIVE: We studied prospectively whether airway responsiveness is associated with the risk of developing COPD. METHODS: We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults)...
May 2, 2018: Thorax
https://www.readbyqxmd.com/read/29715057/how-to-evaluate-potential-non-specific-effects-of-vaccines-the-quest-for-randomized-trials-or-time-for-triangulation
#15
Christine Stabell Benn, Ane Bærent Fisker, Andreas Rieckmann, Aksel Georg Jensen, Peter Aaby
Emerging evidence suggests that vaccines, in addition to their disease-specific effects, have important non-specific effects (NSEs), which contribute to their overall effect on mortality and morbidity. Immunological studies have shown that NSEs are biologically plausible. Many advocate that randomized controlled trials (RCTs) with overall mortality or morbidity as the outcome are the only way forward to confirm or refute NSEs. Areas covered: We discuss the limitations of using RCTs only as a tool to evaluate NSEs of vaccines...
May 1, 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29713323/implication-of-interleukin-12-15-18-and-ruxolitinib-in-the-phenotype-proliferation-and-polyfunctionality-of-human-cytokine-preactivated-natural-killer-cells
#16
Iñigo Terrén, Idoia Mikelez, Irati Odriozola, Andrea Gredilla, Javier González, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Francisco Borrego
A brief in vitro stimulation of natural killer (NK) cells with interleukin (IL)-12, IL-15, and IL-18 endow them a memory-like behavior, characterized by higher effector responses when they are restimulated after a resting period of time. These preactivated NK cells, also known as cytokine-induced memory-like (CIML) NK cells, have several properties that make them a promising tool in cancer immunotherapy. In the present study, we have described the effect that different combinations of IL-12, IL-15, and IL-18 have on the generation of human CIML NK cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29701821/phylogenetic-comparative-methods-on-phylogenetic-networks-with-reticulations
#17
Paul Bastide, Claudia Solís-Lemus, Ricardo Kriebel, K William Sparks, Cécile Ané
The goal of Phylogenetic Comparative Methods (PCMs) is to study the distribution of quantitative traits among related species. The observed traits are often seen as the result of a Brownian Motion (BM) along the branches of a phylogenetic tree. Reticulation events such as hybridization, gene flow or horizontal gene transfer, can substantially affect a species' traits, but are not modeled by a tree. Phylogenetic networks have been designed to represent reticulate evolution. As they become available for downstream analyses, new models of trait evolution are needed, applicable to networks...
April 25, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29696415/medium-term-outcomes-of-the-s-rom-modular-femoral-stem-in-revision-hip-replacement
#18
Jesús Moreta, Iker Uriarte, Xabier Foruria, Ane Loroño, Urko Agirre, Iñaki Jáuregui, José Luis Martínez-de Los Mozos
INTRODUCTION: The objective of this study was to analyse results achieved with the S-ROM modular stem in revision surgery. MATERIALS AND METHODS: A retrospective observational study was conducted from 2007 to 2015 including 51 patients who had a follow-up of ≥ 2 years and complete medical history. The mean age was 66.5 years old (34-87). The main reason for revision was aseptic loosening (38 cases, 74.5%), followed by infection (10, 19.6%), instability (2, 3...
April 25, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29691314/inferring-roles-in-defense-from-metabolic-allocation-of-rice-diterpenoids
#19
Xuan Lu, Juan Zhang, Benjamin Brown, Riqing Li, Julio Rodríguez-Romero, Aileen Berasategui, Bo Liu, Meimei Xu, Dangping Luo, Zhiqiang Pan, Scott Baerson, Jonathan Gershenzon, Zhaohu Li, Ane Sesma, Bing Yang, Reuben J Peters
Among their responses to microbial infection, plants deploy an arsenal of natural antibiotic products. These historically have been identified on the basis of their antibiotic activity in vitro, which leaves open the question of their relevance to defense in planta. The vast majority of such natural products from the important crop plant rice (Oryza sativa) are diterpenoids whose biosynthesis proceeds via either ent- or syn- copalyl diphosphate (CPP) intermediates, and which were isolated on the basis of their antibiotic activity against the fungal blast pathogen Magnaporthe oryzae...
April 24, 2018: Plant Cell
https://www.readbyqxmd.com/read/29689732/a-novel-algorithm-for-thermal-image-encryption
#20
Iqtadar Hussain, Amir Anees, Abdulmohsen Algarni
Thermal images play a vital character at nuclear plants, Power stations, Forensic labs biological research, and petroleum products extraction. Safety of thermal images is very important. Image data has some unique features such as intensity, contrast, homogeneity, entropy and correlation among pixels that is why somehow image encryption is trickier as compare to other encryptions. With conventional image encryption schemes it is normally hard to handle these features. Therefore, cryptographers have paid attention to some attractive properties of the chaotic maps such as randomness and sensitivity to build up novel cryptosystems...
April 16, 2018: Journal of Integrative Neuroscience
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