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https://www.readbyqxmd.com/read/28655157/neuroinflammation-and-tau-interact-with-amyloid-in-predicting-sleep-problems-in-aging-independently-of-atrophy
#1
Anders Martin Fjell, Ane-Victoria Idland, Roser Sala-Llonch, Leiv Otto Watne, Tom Borza, Anne Brækhus, Tarjei Lona, Henrik Zetterberg, Kaj Blennow, Torgeir Bruun Wyller, Kristine Beate Walhovd
Sleep problems relate to brain changes in aging and disease, but the mechanisms are unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep, which is likely augmented by interactions with multiple variables. Here, we tested how different cerebrospinal fluid (CSF) biomarkers for brain pathophysiology, brain atrophy, memory function, and depressive symptoms predicted self-reported sleep patterns in 91 cognitively healthy older adults over a 3-year period. The results showed that CSF levels of total- and phosphorylated (P) tau, and YKL-40-a marker of neuroinflammation/astroglial activation-predicted poor sleep in Aβ positive older adults...
June 26, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28650326/to-evaluate-the-efficacy-and-safety-of-cofnovex-plus-ema-syrup
#2
Zubair Ali, Muhammad Daniyal, Muhammad Khalid Adhia, Anees Alam, Babar Sarfaraz, Abdul Sattar, Khan Usmanghani
The cough and cold are very widespread conditions and a common purpose for advice in general practice. Utmost often the sign and symptoms of cough are produced by acute viral airway infection and the course is frequently benign. But it can be converted into bacterial super-infection and can cause acute bronchitis. Herbal medicines are used to treat symptoms of the cough and cold, and among these medicines Ivy leaf is used to treat mucous discharge and irritation in throat due to the cough and cold. In addition to synthetic substances such as acetylcysteine, carbocisteins, ambroxol and bromhexine, herbal medicines contain saponins, which are used in these indications...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28645970/the-relation-between-birthweight-childhood-body-mass-index-and-overweight-and-obesity-in-late-adolescence-a-longitudinal-cohort-study-from-norway-the-troms%C3%A3-study-fit-futures
#3
Elin Evensen, Nina Emaus, Ane Kokkvoll, Tom Wilsgaard, Anne-Sofie Furberg, Guri Skeie
OBJECTIVES: Childhood overweight/obesity is associated with later overweight/obesity. However, the association between birth weight and later overweight/obesity has not been established. The aim of this study was to investigate the relation between both birth weight and childhood body mass index (BMI), and adolescent overweight/obesity in a Norwegian population. METHODS: The Tromsø Study - Fit Futures is a population-based cohort study conducted in 2010-2011 and 2012-2013 in Tromsø, Norway...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28643466/anemonin-attenuates-osteoarthritis-progression-through-inhibiting-the-activation-of-il-1%C3%AE-nf-%C3%AE%C2%BAb-pathway
#4
Zuqiang Wang, Junlan Huang, Siru Zhou, Fengtao Luo, Wei Xu, Quan Wang, Qiaoyan Tan, Liang Chen, Jun Wang, Hangang Chen, Lin Chen, Yangli Xie, Xiaolan Du
The osteoarthritis (OA) progression is now considered to be related to inflammation. Anemonin (ANE) is a small natural molecule extracted from various kinds of Chinese traditional herbs and has been shown to inhibiting inflammation response. In this study, we examined whether ANE could attenuate the progression of OA via suppression of IL-1β/NF-κB pathway activation. Destabilization of the medial meniscus (DMM) was performed in 10-week-old male C57BL/6J mice. ANE was then intra-articularly injected into joint capsule for 8 and 12 weeks...
June 23, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28642793/repair-of-thoracoabdominal-aortic-aneurysm-with-thrombosed-infrarenal-component-a-modified-hybrid-technique-without-aortic-cross-clamping
#5
Hussam Abou-Al-Shaar, Khaled J Zaza, Muhammad Anees Sharif, Samer Koussayer
The authors report the successful repair of a Crawford type III thoracoabdominal aortic aneurysm (TAAA) with a thrombosed infrarenal component using a modified hybrid technique without aortic clamping in a high-risk patient. A 64-year-old male with a history of hypertension, diabetes, and severe chronic obstructive pulmonary disease presented with acute on chronic backache and bilateral short distance claudication. A computerized tomography scan demonstrated a large, nonleaking Crawford type III TAAA with thrombosed infrarenal component of the aneurysm...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28637706/endothelial-mineralocorticoid-receptor-contributes-to-systolic-dysfunction-induced-by-pressure-overload-without-modulating-cardiac-hypertrophy-or-inflammation
#6
Ane M Salvador, M Elizabeth Moss, Mark Aronovitz, Kathleen B Mueller, Robert M Blanton, Iris Z Jaffe, Pilar Alcaide
Heart Failure (HF) is associated with increased circulating levels of aldosterone and systemic inflammation. Mineralocorticoid receptor (MR) antagonists block aldosterone action and decrease mortality in patients with congestive HF However, the molecular mechanisms underlying the therapeutic benefits of MR antagonists remain unclear. MR is expressed in all cell types in the heart, including the endothelial cells (EC), in which aldosterone induces the expression of intercellular adhesion molecule 1 (ICAM-1)...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28637187/identification-of-pulmonary-vein-reconnection-gaps-with-high-density-mapping-in-redo-atrial-fibrillation-ablation-procedures
#7
Ignacio García-Bolao, Gabriel Ballesteros, Pablo Ramos, Diego Menéndez, Ane Erkiaga, Renzo Neglia, Marta Jiménez Martín, Enrique Vives-Rodríguez
Aims: Maps obtained by means of electroanatomic high-density mapping (HDM) systems have shown their use in the identification of conduction gaps in experimental atrial linear lesion models. The objective of this study was to assess the use of HDM in the recognition of reconnection gaps in pulmonary veins (PV) in redo atrial fibrillation (AF) ablation procedures. Methods and results: One hundred and eight patients were included in a non-randomized study that assessed the recognition of reconnection gaps in PV by means of HDM compared to a control group that received conventional non-fluoroscopic guidance with a circular multipolar catheter (CMC)...
June 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28635546/physical-activity-and-asthma-a-longitudinal-and-multi-country-study
#8
Melissa A Russell, Christer Janson, Francisco Gómez Real, Ane Johannessen, Marie Waatevik, Bryndis Benediktsdóttir, Mathias Holm, Eva Lindberg, Vivi Schlünssen, Wasif Raza, Shyamali C Dharmage, Cecilie Svanes
OBJECTIVE: To investigate the impact of physical activity on asthma in middle-aged adults, in one longitudinal analysis, and one multi-centre cross-sectional analysis. METHODS: The Respiratory Health in Northern Europe (RHINE) is a population-based postal questionnaire cohort study. Physical activity, height and weight were self-reported in Bergen, Norway, at RHINE II (1999-2001) and all centres at RHINE III (2010-2012). A longitudinal analysis of Bergen data investigated the association of baseline physical activity with follow-up asthma, incident asthma and symptoms, using logistic and zero-inflated Poisson regression (n = 1782)...
February 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28635541/association-between-abnormal-brain-functional-connectivity-in-children-and-psychopathology-a-study-based-on-graph-theory-and-machine-learning
#9
João Ricardo Sato, Claudinei Eduardo Biazoli, Giovanni Abrahão Salum, Ary Gadelha, Nicolas Crossley, Gilson Vieira, André Zugman, Felipe Almeida Picon, Pedro Mario Pan, Marcelo Queiroz Hoexter, Edson Amaro, Mauricio Anés, Luciana Monteiro Moura, Marco Antonio Gomes Del'Aquilla, Philip Mcguire, Luis Augusto Rohde, Euripedes Constantino Miguel, Andrea Parolin Jackowski, Rodrigo Affonseca Bressan
OBJECTIVES: One of the major challenges facing psychiatry is how to incorporate biological measures in the classification of mental health disorders. Many of these disorders affect brain development and its connectivity. In this study, we propose a novel method for assessing brain networks based on the combination of a graph theory measure (eigenvector centrality) and a one-class support vector machine (OC-SVM). METHODS: We applied this approach to resting-state fMRI data from 622 children and adolescents...
February 8, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28634498/evaluation-of-in-vitro-cytotoxicity-biocompatibility-and-changes-in-the-expression-of-apoptosis-regulatory-proteins-induced-by-cerium-oxide-nanocrystals
#10
Shahanavaj Khan, Anees A Ansari, Christian Rolfo, Andreia Coelho, Maha Abdulla, Khayal Al-Khayal, Rehan Ahmad
Cerium oxide nanocrystals (CeO2-NCs) exhibit superoxide dismutase and catalase mimetic activities. Based on these catalytic activities, CeO2-NCs have been suggested to have the potential to treat various diseases. The crystalline size of these materials is an important factor that influences the performance of CeO2-NCs. Previous reports have shown that several metal-based nanocrystals, including CeO2-NCs, can induce cytotoxicity in cancer cells. However, the underlying mechanisms have remained unclear. To characterize the anticancer activities of CeO2-NCs, several assays related to the mechanism of cytotoxicity and induction of apoptosis has been performed...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28634387/quasiparticle-and-optical-properties-of-strained-stanene-and-stanane
#11
Pengfei Lu, Liyuan Wu, Chuanghua Yang, Dan Liang, Ruge Quhe, Pengfei Guan, Shumin Wang
Quasiparticle band structures and optical properties of two dimensional stanene and stanane (fully hydrogenated stanene) are studied by the GW and GW plus Bethe-Salpeter equation (GW-BSE) approaches, with inclusion of the spin-orbit coupling (SOC). The SOC effect is significant for the electronic and optical properties in both stanene and stanane, compared with their group IV-enes and IV-anes counterparts. Stanene is a semiconductor with a quasiparticle band gap of 0.10 eV. Stanane has a sizable band gap of 1...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632939/acute-skin-trauma-induces-hyperemia-but-superficial-papillary-nutritive-perfusion-remains-unchanged
#12
Liv Kristin Sundheim, Ane Halse Sporastøyl, Torjus Wester, Göran Salerud, Knut Kvernebo
OBJECTIVES: Superficial skin papillary capillaries with blood supply from a superficial vascular plexus and regulated by local metabolic needs, supply oxygen and nutrient for epithelial cell proliferation. A deep vascular plexus regulated by autonomous nerves serves body thermoregulation. In healthy volunteers we assessed circulatory effects of a standardised skin trauma by computer assisted video m microscopy (CAVM), diffuse reflectance spectroscopy (DRS), and laser Doppler perfusion measurements (LDPM) to assess the measuring depth of the three techniques and to describe the acute trauma effects on nutritive and thermoregulatory perfusion...
June 20, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28631252/synthesis-and-characterization-of-novel-carboxymethyl-assam-bora-rice-starch-for-the-controlled-release-of-cationic-anticancer-drug-based-on-electrostatic-interactions
#13
Sharmistha Mohapatra, Anees Ahmad Siddiqui, Mohammed Anwar, Neha Bhardwaj, Sohail Akhter, Farhan Jalees Ahmad
Carboxymethyl Assam Bora rice starch (CM-ABRS) was chemically synthesized in non-aqueous medium with the optimum degree of substitution (DS) of 1.23, and physicochemically characterized by FT-IR, DSC, XRD, and SEM analysis. Comparative evaluation of CM-ABRS with native starch (ABRS) for powder flow characteristics, swelling index, apparent solubility, rheological properties, textural properties, and mucoadhesive studies were carried out. The aim of the current work was to investigate the potential of CM-ABRS as a novel carrier for the water-soluble chemotherapeutic, doxorubicin hydrochloride (DOX)...
June 19, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28626570/riboflavin-as-a-bioorthogonal-photocatalyst-for-the-activation-of-a-pt-iv-prodrug
#14
Silvia Alonso-de Castro, Emmanuel Ruggiero, Ane Ruiz-de-Angulo, Elixabete Rezabal, Juan C Mareque-Rivas, Xabier Lopez, Fernando López-Gallego, Luca Salassa
Encouraging developments demonstrate that few transition metal and organometallic catalysts can operate in a bioorthogonal fashion and promote non-natural chemistry in living systems by minimizing undesired side reactions with cellular components. These catalytic processes have potential for applications in medicinal chemistry and chemical biology. However, the stringent conditions of the cell environment severely limit the number of accessible metal catalysts and exogenous reactions. Herein, we report an unorthodox approach and a new type of bioorthogonal catalytic reaction, in which a metal complex is an unconventional substrate and an exogenous biological molecule acts as a catalyst...
June 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28626559/reversible-mechanical-protection-building-a-3d-suit-around-a-t-shaped-benzimidazole-axle
#15
Kelong Zhu, Giorgio Baggi, V Nicholas Vukotic, Stephen J Loeb
The T-shaped benzimidazolium/crown ether recognition motif was used to prepare suit[1]anes. These novel mechanically interlocked molecules (MIMs) were fully characterized by (1)H and (13)C NMR spectroscopy, single-crystal X-ray diffraction, UV-vis absorption and fluorescence spectroscopy. By conversion to a suit[1]ane, a simple benzimidazole was shown to be protected from deprotonation by strong base. Moreover, it was demonstrated that this unique three-dimensional encapsulation can be made reversible, thus introducing the concept of "reversible mechanical protection"; a protecting methodology that may have potential applications in synthetic organic chemistry and the design of molecular machinery...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28625787/structural-snapshots-and-loop-dynamics-along-the-catalytic-cycle-of-glycosyltransferase-gpgs
#16
David Albesa-Jové, Javier Romero-García, Enea Sancho-Vaello, F-Xabier Contreras, Ane Rodrigo-Unzueta, Natalia Comino, Ana Carreras-González, Pedro Arrasate, Saioa Urresti, Xevi Biarnés, Antoni Planas, Marcelo E Guerin
Glycosyltransferases (GTs) play a central role in nature. They catalyze the transfer of a sugar moiety to a broad range of acceptor substrates. GTs are highly selective enzymes, allowing the recognition of subtle structural differences in the sequences and stereochemistry of their sugar and acceptor substrates. We report here a series of structural snapshots of the reaction center of the retaining glucosyl-3-phosphoglycerate synthase (GpgS). During this sequence of events, we visualize how the enzyme guides the substrates into the reaction center where the glycosyl transfer reaction takes place, and unveil the mechanism of product release, involving multiple conformational changes not only in the substrates/products but also in the enzyme...
May 26, 2017: Structure
https://www.readbyqxmd.com/read/28624883/heart-rate-recovery-after-6-min-walking-test-predicts-acute-exacerbation-in-copd
#17
Diego A Rodríguez, Eleni A Kortianou, Jennifer A Alison, Alejandro Casas, Santiago Giavedoni, Anael Barberan-Garcia, Ane Arbillaga, Jordi Vilaró, Elena Gimeno-Santos, Ioannis Vogiatzis, Roberto Rabinovich, Josep Roca
INTRODUCTION: Abnormalities of autonomic function have been reported in patients with chronic obstructive pulmonary disease (COPD). Our objectives were to identify determinants of abnormal heart rate recovery at 1 min (HRR1) following completion of the 6-min walk test (6MWT) in COPD and to establish whether abnormal HRR1 predicts acute exacerbations (AECOPD). METHODS: Hundred one COPD patients (FEV1 (SD) 53 (19)  % predicted) were prospectively recruited in a multi-center study...
June 17, 2017: Lung
https://www.readbyqxmd.com/read/28621225/decreased-expression-of-mgmt-in-correlation-with-aberrant-dna-methylation-in-esophageal-cancer-patients-from-north-india
#18
Asad Ur Rehman, Snigdha Saikia, Mohammad Askandar Iqbal, Istaq Ahmad, Sadaf, Afzal Anees, P S Aravinda, Pramod Kumar Mishra, Suresh Hedau, Sundeep Singh Saluja, Subhash Medhi, Syed Akhtar Husain
O-6-methylguanine-DNA methyltransferase, DNA repair gene, has been found to be involved with the pathogenesis of the esophageal cancer. DNA hypermethylation and other factors have been suggested to downregulate O-6-methylguanine-DNA methyltransferase. In this communication, the methylation status of O-6-methylguanine-DNA methyltransferase gene and the corresponding O-6-methylguanine-DNA methyltransferase protein expression in esophageal cancer from North India has been studied. In all, 80 samples of tumor tissue along with adjacent normal tissue as controls were analyzed for messenger RNA level of O-6-methylguanine-DNA methyltransferase gene, protein expression, and subcellular localization...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28620434/top-tips-to-deal-with-challenging-situations-doctor-patient-interactions
#19
Georgia Hardavella, Ane Aamli-Gaagnat, Armin Frille, Neil Saad, Alexandra Niculescu, Pippa Powell
When challenging situations arise in doctor-patient interactions, how can we best manage them? http://ow.ly/J1GI30bD5wp.
June 2017: Breathe
https://www.readbyqxmd.com/read/28619764/medicoeconomic-analysis-of-lobectomy-using-thoracoscopy-versus-thoracotomy-for-lung-cancer-a-study-protocol-for-a-multicentre-randomised-controlled-trial-lungsco01
#20
Pierre-Benoit Pagès, Halim Abou Hanna, Anne-Claire Bertaux, Ludwig Serge Serge Aho, Pierre Magdaleinat, Jean-Marc Baste, Marc Filaire, Richard de Latour, Jalal Assouad, François Tronc, Christophe Jayle, Jérome Mouroux, Pascal-Alexandre Thomas, Pierre-Emmanuel Falcoz, Charles-Henri Marty-Ané, Alain Bernard
INTRODUCTION: In the last decade, video-assisted thoracoscopic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC) has had a major effect on thoracic surgery. Retrospective series have reported benefits of VATS when compared with open thoracotomy in terms of postoperative pain, postoperative complications and length of hospital stay. However, no large randomised control trial has been conducted to assess the reality of the potential benefits of VATS lobectomy or its medicoeconomic impact...
June 15, 2017: BMJ Open
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