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Hui Yin Lim, Harshal Nandurkar, Prahlad Ho
The advent of direct oral anticoagulants (DOACs) has revolutionized anticoagulation management in both stroke prevention and venous thromboembolism (VTE) treatment/prevention. Clinical trials and secondary real-world data have shown that DOACs have similar efficacy and, in some cases, improved bleeding safety profiles compared with vitamin K antagonists. Together with benefits of patient convenience, this has shifted the risk-benefit ratio toward long-term anticoagulation. However, current VTE risk assessment models are based on vitamin K antagonists and do not take into account the new paradigm of DOACs...
March 20, 2018: Seminars in Thrombosis and Hemostasis
Amy L Donaldson, Mariella Nolfo, Marissa Montejano
Children with autism may perceive friendship in a qualitatively different manner than their neurotypical peers. Yet, these friendships have been reported as satisfying to the child with autism spectrum disorder (ASD). Although many studies have identified lower quality of friendship in ASD, reduced reciprocity, and increased loneliness and depression, perhaps it is time to take a closer look at the perspective of autistic individuals and to identify how the broader community influences development of relationships and friendship...
April 2018: Seminars in Speech and Language
Adam Kasparek, Bogdan Smyk
The fluorescence technique is very popular and has been used in many fields of research. It is simple in its assumptions but not very easy to use. One of the main problems is the inner filter effect (IF) I and II which takes place in the cuvette. IF type I is permanently present, but IF type II occurs only when absorption and fluorescence spectra overlap. To avoid IF type I, absorbencies in the cuvette should be smaller than 0.05, which is however very difficult to obtain in many experiments. In this work we propose a new method to solve these problems in the case of a Cary Eclipse fluorimeter, having horizontally-oriented slits, based on old equations developed in the middle of the last century...
March 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Morteza Karimzadeh, Neda Manouchehri, Dariush Saberi, Khodabakhsh Niknam
All 66 conformers of guanylurea were optimized and frequency calculations were performed at M06-2X/6-311++G(d,p) level of theory. Theses conformers were categorized into five tautomers, and the most stable conformer of each tautomer were found. Geometrical parameters indicated that these tautomers have almost planar structure. Complete stepwise tautomerism were studied through both intramolecular proton transfer routs and internal rotations. Results indicated that the proton transfer routs involving four-membered heterocyclic structures were rate-determining steps...
March 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Yu-Jun Zheng, Xiao-Han Zhou, Wei-Guo Sheng, Yu Xue, Sheng-Yong Chen
Recently telecom fraud has become a serious problem especially in developing countries such as China. At present, it can be very difficult to coordinate different agencies to prevent fraud completely. In this paper we study how to detect large transfers that are sent from victims deceived by fraudsters at the receiving bank. We propose a new generative adversarial network (GAN) based model to calculate for each large transfer a probability that it is fraudulent, such that the bank can take appropriate measures to prevent potential fraudsters to take the money if the probability exceeds a threshold...
March 5, 2018: Neural Networks: the Official Journal of the International Neural Network Society
Katarina Harasimov, Melina Schuh
Contractile actin networks take on various functions in cells. How disordered actin networks contract is still poorly understood. A recent study proposes a contractile mechanism that is driven by actin disassembly and required to prevent chromosome losses in starfish oocytes.
March 19, 2018: Current Biology: CB
Laura K Ferris
No abstract text is available yet for this article.
March 20, 2018: JAMA Oncology
Ross J Thomson, Nay Aung, Mihir M Sanghvi, Jose Miguel Paiva, Aaron M Lee, Filip Zemrak, Kenneth Fung, Paul E Pfeffer, Alexander J Mackay, Tricia M McKeever, Elena Lukaschuk, Valentina Carapella, Young Jin Kim, Charlotte E Bolton, Stefan K Piechnik, Stefan Neubauer, Steffen E Petersen
BACKGROUND: Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and cardiovascular structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored. METHODS: UK Biobank is a prospective cohort study of community participants in the United Kingdom...
2018: PloS One
Emily S Mohn, Hua J Kern, Edward Saltzman, Susan H Mitmesser, Diane L McKay
The long-term use of prescription and over-the-counter drugs can induce subclinical and clinically relevant micronutrient deficiencies, which may develop gradually over months or even years. Given the large number of medications currently available, the number of research studies examining potential drug-nutrient interactions is quite limited. A comprehensive, updated review of the potential drug-nutrient interactions with chronic use of the most often prescribed medications for commonly diagnosed conditions among the general U...
March 20, 2018: Pharmaceutics
Daniela Dias, Oxana Tchepel
Analyzing individual exposure in urban areas offers several challenges where both the individual's activities and air pollution levels demonstrate a large degree of spatial and temporal dynamics. This review article discusses the concepts, key elements, current developments in assessing personal exposure to urban air pollution (seventy-two studies reviewed) and respective advantages and disadvantages. A new conceptual structure to organize personal exposure assessment methods is proposed according to two classification criteria: (i) spatial-temporal variations of individuals' activities (point-fixed or trajectory based) and (ii) characterization of air quality (variable or uniform)...
March 20, 2018: International Journal of Environmental Research and Public Health
Catarina Brazão Farinha, Jorge de Brito, Rosário Veiga, J M Fernández, J R Jiménez, A R Esquinas
The production of waste has increased over the years and, lacking a recycle or recovery solution, it is forwarded to landfill. The incorporation of wastes in cement-based materials is a solution to reduce waste deposition. In this regard, some researchers have been studying the incorporation of wastes with different functions: aggregate, binder and addition. The incorporation of wastes should take advantage of their characteristics. It requires a judicious analysis of their particles. This research involves the analysis of seven industrial wastes: biomass ashes, glass fibre, reinforced polymer dust, sanitary ware, fluid catalytic cracking, acrylic fibre, textile fibre and glass fibre...
March 20, 2018: Materials
Sebastian Povlsen, Bo Povlsen
The diagnosis of thoracic outlet syndrome (TOS) has long been a controversial and challenging one. Despite common presentations with pain in the neck and upper extremity, there are a host of presenting patterns that can vary within and between the subdivisions of neurogenic, venous, and arterial TOS. Furthermore, there is a plethora of differential diagnoses, from peripheral compressive neuropathies, to intrinsic shoulder pathologies, to pathologies at the cervical spine. Depending on the subdivision of TOS suspected, diagnostic investigations are currently of varying importance, necessitating high dependence on good history taking and clinical examination...
March 20, 2018: Diagnostics
Yi Lu, Zhonghua Gou, Yang Xiao, Chinmoy Sarkar, John Zacharias
A sharp drop in physical activity and skyrocketing obesity rate has accompanied rapid urbanization in China. The urban planning concept of transit-oriented development (TOD) has been widely advocated in China to promote physical activity, especially walking. Indeed, many design features thought to promote walking-e.g., mixed land use, densification, and well-connected street network-often characterize both TODs and established urban neighborhoods. Thus, it is often assumed that TODs have similar physical activity benefits as established urban neighborhoods...
March 20, 2018: International Journal of Environmental Research and Public Health
Brendan A Andres, Benjamin R Childs, Heather A Vallier
OBJECTIVES: To determine the incidence of hypovitaminosis D and to evaluate a supplementation intervention. We hypothesized that patients would exhibit high adherence with a free sample, and levels would become sufficient. DESIGN: Prospective observational study. SETTING: Level 1 trauma center. PATIENTS: One hundred forty-four consecutive, skeletally mature patients treated for acute fractures. INTERVENTION: All were provided 600 mg calcium and 800 IU vitamin D3 capsules twice daily...
April 2018: Journal of Orthopaedic Trauma
Olga Kostrzewa, Paweł Kołodziej, Maria Majdan, Robert Zwolak, Anna Górak, Krzysztof Bar
In this article we have presented a case of 31-year-old male with thickening of the skin and tender cord of superficial veins of the penis and laboratory findings of the high titer of PM/Scl-100 antibodies in the serum. The patient was referred to the Rheumatology Department due to suspected systemic sclerosis. The HRCT scan of his lungs revealed fibrous degeneration and ground-glass opacity in the lower lobes. Capillaroscopy showed abnormalities, which were not typical for systemic sclerosis. In Doppler ultrasound examination of penis, superficial dorsal and circumflex veins thrombosis and inflammatory infiltration were observed...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Andrzej N Majda, Aleksandra Majdan, Paweł Piłat, Paweł Cisek
Gout tophi around auricular area are common in old men. The differential diagnosis of papules or nodules on the ear includes tophaceous gout, rheumatoid nodules, basal or squamous cell cancer, melanoma, verruca vulgaris or actinic keratosis. The presence of the skin cancer, most commonly located on the head and neck, is often related to the long exposure of the skin to sunlight. Elderly patients are the predominant group of patients with skin malignancies. The aim of this study is to emphasize the importance of early cancer detection in elderly people and use of appropriate therapeutic options that take into account the special requirements of geriatric patients...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Michelle Hershman, Raymond Carmody, Unni K Udayasankar
History A 19-year-old woman with no pertinent medical history was brought to the emergency department after being found unconscious on her bathroom floor by her roommate. In the preceding weeks, she had reported intractable nausea and vomiting, for which she had been taking ondansetron. No other medications had been prescribed. The day prior to presentation, she had contacted her mother and described increasing confusion. Glasgow coma scale score on arrival in the emergency department was 4. Intravenous naloxone was administered, without immediate response...
April 2018: Radiology
Eric Vanman, Rosemary Baker, Stephanie Tobin
People occasionally choose to cut themselves off from their online social network by taking extended breaks from Facebook. This study investigated whether abstaining from Facebook reduces stress but also reduces subjective well-being because of the resulting social disconnection. Participants (138 active Facebook users) were assigned to either a condition in which they were instructed to give up Facebook for five days or continue to use Facebook as normal. Perceived stress and well-being, as well as salivary cortisol, were measured before and after the test period...
March 20, 2018: Journal of Social Psychology
D B Krupp, Thomas R Cook
Inequality is widely believed to incite conflict, but the evidence is inconsistent. We argue that the spatial scale of competition-the extent to which individuals compete locally, with their interaction partners, or globally, with the entire population-can help settle the question. We built a mathematical model of the evolution of conflict under inequality and tested its predictions in an experimental game with 1,205 participants. We found that inequality increases conflict, destroys wealth, and engenders risk taking...
March 1, 2018: Psychological Science
Breton M Asken, Russell M Bauer, Kevin M Guskiewicz, Michael A McCrea, Julianne D Schmidt, Christopher C Giza, Aliyah R Snyder, Zachary M Houck, Anthony P Kontos, Thomas W McAllister, Steven P Broglio, James R Clugston, Scott Anderson, Jeff Bazarian, Alison Brooks, Thomas Buckley, Sara Chrisman, Michael Collins, John DiFiori, Stefan Duma, Brian Dykhuizen, James T Eckner, Luis Feigenbaum, April Hoy, Louise Kelly, T Dianne Langford, Laura Lintner, Gerald McGinty, Jason Mihalik, Christopher Miles, Justus Ortega, Nicholas Port, Margot Putukian, Steve Rowson, Steven Svoboda
BACKGROUND: Timely removal from activity after concussion symptoms remains problematic despite heightened awareness. Previous studies indicated potential adverse effects of continuing to participate in physical activity immediately after sustaining a concussion. Hypothesis/Purpose: The purpose was to determine the effect of timing of removal from play after concussion on clinical outcomes. It was hypothesized that immediate removal from activity after sport-related concussion (SRC) would be associated with less time missed from sport, a shorter symptomatic period, and better outcomes on acute clinical measures...
March 1, 2018: American Journal of Sports Medicine
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