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https://www.readbyqxmd.com/read/28078982/phytochemicals-a-novel-and-prominent-source-of-anti-cancer-drugs-against-colorectal-cancer
#1
Ravikiran Mahadevappa, Hang Fai Kwok
Colorectal cancer (CRC) is a malignant disease whose incidence and mortality rates are greatly influenced by environmental factors. Under-treatment of CRC such as a poor diagnostic evaluation, less aggressive surgery, less intensive chemotherapy results in metastasizing of the primary tumor cells and recurrence of cancer. Prolonged chemotherapy treatment against cancer is hazardous to the patients, which also limits its use in cancer therapy. Current research in developing a novel anti-cancer agent, direct towards finding a better anti-metastatic and an anti-invasive drug with reduced side effects...
January 12, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28073813/association-between-the-healthy-eating-index-2010-and-nutrient-and-energy-densities-of-german-households-food-purchases
#2
Jonas Peltner, Silke Thiele
BACKGROUND: The USDA Healthy Eating Index (HEI) is used widely to measure diet quality because it allows a number of different applications. Although several evaluations of the HEI-2010 have already been carried out, there is lack of those which focus on associations between the HEI and nutrient intakes. This study updates and expands upon previous findings on these associations. METHODS: Using German consumption data, where ∼12 million purchases from 13 131 households are recorded, HEI-2010 total and individual scores, as well as several energy and nutrient densities were calculated...
January 9, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28071023/effect-of-food-processing-on-the-physicochemical-properties-of-dietary-fibre
#3
Vasfiye Hazal Ozyurt, Semih Ötles
Products derived from the manufacturing or processing of plant based foods: cereals, fruits, vegetables, as well as algae, are sources of abundant dietary fibre. Diets high in dietary fibre have been associated with the reduced risk of cardiovascular disease, diabetes, hypertension, obesity, and gastrointestinal disorders. These fibre-rich products and byproducts can also fortify foods, increase their dietary fibre content and result in healthy products, low in calories, cholesterol and fat. Traditionally, consumers have chosen foods such as whole grains, fruits and vegetables as sources of dietary fibre...
July 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28070319/development-of-a-nutrient-dense-complementary-food-using-amaranth-sorghum-grains
#4
Judith Kanensi Okoth, Sophie Atieno Ochola, Nicholas K Gikonyo, Anselimo Makokha
Thin porridge from cereals and starchy tubers is a common complementary food in Sub Saharan Africa. It may be high in antinutrients, low in energy, and nutrient density hence inadequate in providing infants' high energy and nutrients requirements per unit body weight. Consequently, undernourishment levels among children under 5 years are high. Therefore, there is need to avail nutrient-dense complementary foods especially for children in low-resource settings. The study was aimed at developing a nutrient-dense complementary food from amaranth and sorghum grains...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28068147/do-wellness-tourists-get-well-an-observational-study-of-multiple-dimensions-of-health-and-well-being-after-a-week-long-retreat
#5
Marc M Cohen, Fiona Elliott, Liza Oates, Adrian Schembri, Nitin Mantri
BACKGROUND: Wellness retreats use many complementary and alternative therapies within a holistic residential setting, yet few studies have evaluated the effect of retreat experiences on multiple dimensions of health and well-being, and no published studies have reported health outcomes in wellness tourists. OBJECTIVES: To assess the effect of a week-long wellness-retreat experience in wellness tourists. DESIGN: A longitudinal observational study with outcomes assessed upon arrival and departure and 6 weeks after the retreat...
January 9, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28061409/air-pollution-tolerance-index-of-plants-around-brick-kilns-in-rawalpindi-pakistan
#6
Khanoranga Achakzai, Sofia Khalid, Muhammad Adrees, Aasma Bibi, Shafaqat Ali, Rab Nawaz, Muhammad Rizwan
In any contaminated environment, the sensitive plant species can serve as bio-indicator of air pollution while tolerant plant species can act as a sink for air pollutants. Air pollution tolerance index (APTI) is an important tool to screen out plants based on their tolerance or sensitivity level to different air pollutants. The present study was aimed to identify the sensitive and tolerant plant species in the vicinity of brick kilns in the Rawalpindi city. To determine the susceptibility level of the selected plant species, four biochemical parameters, ascorbic acid, total chlorophyll content, relative water content and pH of leaf extract, were assessed and APTI was calculated...
January 3, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28056757/phytochemical-therapies-in-vascular-functioning-a-molecular-approach
#7
Hasan Gencoglu, Cemal Orhan, Kazim Sahin
There has been an increasing interest in the usage of natural products for the prevention and treatment of chronic diseases such as cardiovascular disease (CVD). Regular consumption of fruits, vegetables and whole grains has been shown to be negatively correlated with the risk of CVDs. These foods provide a diversity of nutrients and different bioactive compounds including phytochemicals, vitamins, minerals and fibers which play critical roles in the sustainability of optimal cardiovascular health. Plant-based foods or a nutritional cure are gradually being integrated into medical practice for CVD management partly due to the supporting experimental studies, clinical trials and epidemiological studies...
January 5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28053888/a-glimpse-of-ayurveda-the-forgotten-history-and-principles-of-indian-traditional-medicine
#8
REVIEW
Yogini S Jaiswal, Leonard L Williams
Ayurveda is considered as one of the oldest of the traditional systems of medicine (TSMs) accepted worldwide. The ancient wisdom in this traditional system of medicine is still not exhaustively explored. The junction of the rich knowledge from different traditional systems of medicine can lead to new avenues in herbal drug discovery process. The lack of the understanding of the differences and similarities between the theoretical doctrines of these systems is the major hurdle towards their convergence apart from the other impediments in the discovery of plant based medicines...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28043490/antimycobacterial-activity-of-medicinal-plants-against-the-causative-agent-of-buruli-ulcer-mycobacterium-ulcerans
#9
R Keumoe, M S Nguembou, F P V Tsouh, D V F Donkeng, D Dize, Y L R Tchokouaha, M C D Jiatsa, F R D Youmsi, B Ngameni, B F Fekam
OBJECTIVE/BACKGROUND: Buruli ulcer, known as necrotizing skin disease caused by Mycobacterium ulcerans, has emerged as the most prevalent mycobacteriosis after leprosy and tuberculosis. Accordingly, it has been classified by the World Health Organization as a neglected disease with high significance in tropical areas, including Cameroon. So far, the control of the disease relies mainly on the rifampin-streptomycin combination. Despite its efficiency, it has shown considerable issues, including availability and side effects...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28035338/human-gut-microbiota-and-healthy-aging-recent-developments-and-future-prospective
#10
REVIEW
Manish Kumar, Parizad Babaei, Boyang Ji, Jens Nielsen
The human gut microbiota alters with the aging process. In the first 2-3 years of life, the gut microbiota varies extensively in composition and metabolic functions. After this period, the gut microbiota demonstrates adult-like more stable and diverse microbial species. However, at old age, deterioration of physiological functions of the human body enforces the decrement in count of beneficial species (e.g. Bifidobacteria) in the gut microbiota, which promotes various gut-related diseases (e.g. inflammatory bowel disease)...
October 27, 2016: Nutr Healthy Aging
https://www.readbyqxmd.com/read/28031235/htp-nutraceutical-screening-for-histone-deacetylase-inhibitors-and-effects-of-hdacis-on-tumor-suppressing-mirnas-by-trichostatin-a-and-grapeseed-vitis-vinifera-in-hela-cells
#11
Elizabeth A Mazzio, Karam F A Soliman
BACKGROUND/AIM: Aggressive tumor malignancies are a consequence of delayed diagnosis, epigenetic/phenotype changes and chemo-radiation resistance. Histone deacetylases (HDACs) are a major epigenetic regulator of transcriptional repression, which are highly overexpressed in advanced malignancy. While original chemotherapy drugs were modeled after phytochemicals elucidated by botanical screenings, HDAC inhibitors (HDACi) such as apicidin, trichostatin A (TSA) and butyrate were discovered as products of fungus and microbes, in particular, gut microbiota...
January 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28030622/effects-of-menthol-supplementation-in-feedlot-cattle-diets-on-the-fecal-prevalence-of-antimicrobial-resistant-escherichia-coli
#12
C C Aperce, R Amachawadi, C L Van Bibber-Krueger, T G Nagaraja, H M Scott, J Vinasco-Torre, J S Drouillard
The pool of antimicrobial resistance determinants in the environment and in the gut flora of cattle is a serious public health concern. In addition to being a source of human exposure, these bacteria can transfer antibiotic resistance determinants to pathogenic bacteria and endanger the future of antimicrobial therapy. The occurrence of antimicrobial resistance genes on mobile genetic elements, such as plasmids, facilitates spread of resistance. Recent work has shown in vitro anti-plasmid activity of menthol, a plant-based compound with the potential to be used as a feed additive to beneficially alter ruminal fermentation...
2016: PloS One
https://www.readbyqxmd.com/read/28008675/exploring-%C3%AE-tubulin-inhibitors-from-plant-origin-using-computational-approach
#13
Kanika Verma, Kaavya Kannan, Shanthi V, Sethumadhavan R, Karthick V, Ramanathan K
INTRODUCTION: β-Tubulin is an important target for the binding of anti-cancer drugs, in particular, paclitaxel (taxol), vinblastine and epothilone. However, mutations in β-tubulin structure give resistance to chemotherapeutic agents. Notably, mutations at R306C, F270 V, L217R, L228F, A185T and A248V positions in β-tubulin give high resistance for paclitaxel binding. OBJECTIVE: To discover novel inhibitors of β-tubulin from natural sources, particularly alkaloids, using a virtual screening approach...
December 23, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28008371/mindful-climate-action-health-and-environmental-co-benefits-from-mindfulness-based-behavioral-training
#14
Bruce Barrett, Maggie Grabow, Cathy Middlecamp, Margaret Mooney, Mary M Checovich, Alexander K Converse, Bob Gillespie, Julia Yates
Greenhouse gases from human activities are causing climate change, creating risks for people around the globe. Behaviors involving transportation, diet, energy use, and purchasing drive greenhouse gas emissions, but are also related to health and well-being, providing opportunity for co-benefits. Replacing shorter automobile trips with walking or cycling, or eating plants rather than animals, for example, may increase personal health, while also reducing environmental impact. Mindfulness-based practices have been shown to enhance a variety of health outcomes, but have not been adapted towards environmental purposes...
October 2016: Sustainability
https://www.readbyqxmd.com/read/28008315/plant-protease-inhibitors-in-therapeutics-focus-on-cancer-therapy
#15
REVIEW
Sandhya Srikanth, Zhong Chen
Plants are known to have many secondary metabolites and phytochemical compounds which are highly explored at biochemical and molecular genetics level and exploited enormously in the human health care sector. However, there are other less explored small molecular weight proteins, which inhibit proteases/proteinases. Plants are good sources of protease inhibitors (PIs) which protect them against diseases, insects, pests, and herbivores. In the past, proteinaceous PIs were considered primarily as protein-degrading enzymes...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28007527/applications-of-higenamine-in-pharmacology-and-medicine
#16
REVIEW
Nana Zhang, Zeqin Lian, Xueying Peng, Zijian Li, Haibo Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: Aconitum has been used as local and traditional medicines in many asian regions for the treatment of various diseases such as collapse, syncope, painful joints, oedema, bronchial asthma et al. Higenamine, a plant-based alkaloid, was initially isolated from Aconitum and identified as the active cardiotonic component of Aconitum. It has been tested as a candidate of pharmacologic stress agent in the detection of coronary artery diseases (CADs) and now researchers have just accomplished the phase III clinical studies successfully in China...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28000568/plant-peptides-bioactivity-opportunities-and-challenges
#17
Indira P Sarethy
Bioactive peptides from plants are an underexplored domain in the field of proteomics and peptidomics. Recent evidences of plant peptides being more than chemical signals and indeed, functioning in the responses of plants to diverse environmental cues such as stress and infection by pathogens, suggests their potentially wide applicability in agrochemical and pharmaceutical industries. With cutting-edge technologies available, studies on plant peptides still lag behind those from food or microorganisms. The current mini-review provides an overview of the major bioactivity documented of plant-based peptides...
December 20, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27999938/characterization-of-cinnamoyl-esterases-from-different-lactobacilli-and-bifidobacteria
#18
Caroline Fritsch, André Jänsch, Matthias A Ehrmann, Simone Toelstede, Rudi F Vogel
A high variety of plants that are used for food production contain esterified hydroxycinnamic acids. As their free forms display several benefits, like an enhanced absorption in human intestinal tract, anti-oxidative and anti-carcinogenic effects, an improved protein solubility and reduced discoloration, the microbial ability to cleave the ester bond is highly desired. In order to examine potential fermentation strains for this purpose, six different lactic acid bacteria and one bifidobacterial strain were screened for their ability to degrade esterified hydroxycinnamic acids because these strains are commonly used for fermentation of plant-based foods...
December 21, 2016: Current Microbiology
https://www.readbyqxmd.com/read/27987966/guar-gum-as-biosourced-building-block-to-generate-highly-conductive-and-elastic-ionogels-with-poly-ionic-liquid-and-ionic-liquid
#19
Biao Zhang, Guillaume Sudre, Guilhem Quintard, Anatoli Serghei, Laurent David, Julien Bernard, Etienne Fleury, Aurélia Charlot
In this study, we report on the simple and straightforward preparation of ionogels arising from the addition of guar gum (a plant-based polysaccharide) in a solution of precisely-defined poly(ionic liquid) chains (PIL) in imidazolium-based ionic liquid (IL). The development of intermolecular polar interactions (mainly hydrogen bonds) and topologic chain entanglements induces the formation of physical biohybrid ionogels, whose elastic properties can be easily tuned by varying the composition (up to 30000Pa)...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27976356/molecular-phylogenetics-as-a-predictive-tool-in-plant-based-drug-discovery-in-the-genus-euphorbia-l
#20
M Ernst, C H Saslis-Lagoudakis, O M Grace, N Nilsson, H Toft Simonsen, J W Horn, D Stærk, N Rønsted
No abstract text is available yet for this article.
December 2016: Planta Medica
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