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Tonsillar lymphoma

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https://www.readbyqxmd.com/read/29277098/targeted-tonsillar-biopsy-for-unilateral-tonsillar-enlargement
#1
Truong An Pham, Robert G Berkowitz
BACKGROUND: Unilateral tonsillar enlargement (UTE) is not an uncommon incidental finding. Lymphoma is the most common malignancy of the tonsils in children and presents with tonsillar enlargement. METHODS: This is a retrospective case series of all cases of histopathological analysis of tonsillectomy specimens at a single pediatric tertiary hospital between 1996 and 2015. Patients either had a preoperative indication (n = 53) for pathological testing or indications based on intraoperative findings (n = 88)...
December 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29241019/quantitative-analysis-of-a-multiplexed-immunofluorescence-panel-in-t-cell-lymphoma
#2
Siok-Bian Ng, Shuangyi Fan, Shoa-Nian Choo, Michal Hoppe, Hoang Mai Phuong, Sanjay De Mel, Anand D Jeyasekharan
Immunohistochemistry (IHC) provides clinically useful information on protein expression in cancer cells. However, quantification of colocalizing signals using conventional IHC and visual scores is challenging. Here we describe the application of quantitative immunofluorescence in angioimmunoblastic T-cell lymphoma (AITL), a peripheral T-cell lymphoma characterized by cellular heterogeneity that impedes IHC interpretation and quantification. A multiplexed immunofluorescence (IF) panel comprising T- and B-lymphocyte markers along with T-follicular helper (TFH) markers was validated for appropriate cellular localization in sections of benign tonsillar tissue and tested in two samples of AITL, using a Vectra microscope for spectral imaging and InForm software for analysis...
December 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28929544/computed-tomographic-appearance-of-canine-tonsillar-neoplasia-14-cases
#3
Florence Thierry, Maurizio Longo, Evi Pecceu, Davide D Zani, Tobias Schwarz
The palatine tonsil is an uncommon site of oral canine neoplasia. For affected tonsils, squamous cell carcinoma is the most frequent type of neoplasia, followed by melanoma and lymphoma. Computed tomography (CT) is increasingly used for investigation of canine oropharyngeal pathology; however, limited information is available on the CT appearance of tonsillar neoplasms. Objectives of this retrospective descriptive case series were to characterize the CT features of canine tonsillar neoplasia and determine whether specific CT features differentiate nonneoplastic from neoplastic tonsils...
September 19, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28916523/cutting-edge-a-critical-role-of-lesional-t-follicular-helper-cells-in-the-pathogenesis-of-igg4-related-disease
#4
Ryuta Kamekura, Kenichi Takano, Motohisa Yamamoto, Koji Kawata, Katsunori Shigehara, Sumito Jitsukawa, Tomonori Nagaya, Fumie Ito, Akinori Sato, Noriko Ogasawara, Chieko Tsubomatsu, Hiroki Takahashi, Hiroshi Nakase, Tetsuo Himi, Shingo Ichimiya
IgG4-related disease (IgG4-RD) is a newly recognized systemic chronic fibroinflammatory disease. However, the pathogenesis of IgG4-RD remains unknown. To determine the pathophysiologic features of IgG4-RD, we examined T follicular helper (Tfh) cells in lesions and blood from patients with IgG4-RD. Patients with IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) showed increased infiltration of Tfh cells highly expressing programmed death 1 and ICOS in submandibular glands. Tfh cells from IgG4-DS submandibular glands had higher expression of B cell lymphoma 6 and a greater capacity to help B cells produce IgG4 than did tonsillar Tfh cells...
October 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28884033/high-grade-b-cell-neoplasm-with-surface-light-chain-restriction-and-tdt-coexpression-evolved-in-a-myc-rearranged-diffuse-large-b-cell-lymphoma-a-dilemma-in-classification
#5
Dina Sameh Soliman, Ahmad Al-Sabbagh, Feryal Ibrahim, Ruba Y Taha, Zafar Nawaz, Sarah Elkourashy, Abdulrazzaq Haider, Susanna Akiki, Mohamed Yassin
According to World Health Organization (WHO) classification (2008), B-cell neoplasms are classified into precursor B-cell or a mature B-cell phenotype and this classification was also kept in the latest WHO revision (2016). We are reporting a male patient in his fifties, with tonsillar swelling diagnosed as diffuse large B-cell lymphoma (DLBCL), germinal center. He received 6 cycles of RCHOP and showed complete metabolic response. Two months later, he presented with severe CNS symptoms. Flow cytometry on bone marrow (BM) showed infiltration by CD10-positive Kappa-restricted B-cells with loss of CD20 and CD19, and downregulation of CD79b...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28875091/demographics-of-head-and-neck-cancer-patients-a-single-institution-experience
#6
George S Stoyanov, Martina Kitanova, Deyan L Dzhenkov, Peter Ghenev, Nikolay Sapundzhiev
Introduction Head and neck cancer (HNC) comprises a diverse group of oncological entities, originating from various tissue types and organ localizations, situated in the topographical regions of the head and neck (H&N). This single institution retrospective study was aimed at establishing the HNC patient demographics and categorizing the individual incidence of H&N malignancies, regarding their organ of origin and main histopathological type. Materials and methods All histologically verified cases of HNC from a single tertiary referral center were reviewed in a descriptive retrospective manner...
July 2, 2017: Curēus
https://www.readbyqxmd.com/read/28555346/endobronchial-metastasis-from-extrapulmonary-neoplasms-analysis-of-clinicopathologic-features-and-cytological-evaluation-by-bronchial-brushing
#7
Kenji Ikemura, Diana Murro Lin, Colin P Martyn, Ji-Weon Park, Christopher W Seder, Paolo Gattuso
PURPOSE: Bronchial brushings (BB) commonly aid in the diagnosis of primary lung cancer. However, the utility of this method in diagnosing endobronchial metastases (EBM) from extrapulmonic malignancies has not been thoroughly evaluated. The purpose of this study is to evaluate the sensitivity of BB in diagnosing EBM. METHODS: An institutional database was queried for all patients with cytologically or histologically confirmed extrapulmonary EBM identified by endobronchial biopsy between 1978 and 2013...
October 2017: Lung
https://www.readbyqxmd.com/read/28364261/regulation-of-cell-surface-cb2-receptor-during-human-b-cell-activation-and-differentiation
#8
Julie T Castaneda, Airi Harui, Michael D Roth
Cannabinoid receptor type 2 (CB2) is the primary receptor pathway mediating the immunologic consequences of cannabinoids. We recently reported that human peripheral blood B cells express CB2 on both the extracellular membrane and at intracellular sites, where-as monocytes and T cells only express intracellular CB2. To better understand the pattern of CB2 expression by human B cells, we examined CD20(+) B cells from three tissue sources. Both surface and intracellular expression were present and uniform in cord blood B cells, where all cells exhibited a naïve mature phenotype (IgD(+)/CD38(Dim))...
September 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28351195/utility-of-flow-cytometry-in-diagnosing-hematologic-malignancy-in-tonsillar-tissue
#9
Omonigho Aisagbonhi, Michelle DeLelys, Nicole Hartford, Frederic Preffer, Amy Ly
OBJECTIVE: Tonsil surgical biopsy or excision is a very common procedure. However, there exist no consensus guidelines for the pathologic handling of tonsil specimens; gross and/or microscopic evaluation may be used. Diagnosis of tonsillar hematologic malignancy requires histology, immunohistochemistry and/or flow cytometry. Data regarding the utility of flow cytometry in tonsillar tissues are limited. We assessed our experience with flow cytometry for tonsil diagnosis with regard to accuracy and use patterns at a tertiary academic medical center...
March 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28112344/-tonsillar-actinomycosis-mimicking-relapse-of-diffuse-large-b-cell-non-hodgkin-lymphoma
#10
Frederico Carvalho de Medeiros, Fernando Carvalho de Medeiros
No abstract text is available yet for this article.
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28030899/analysis-of-treatment-outcomes-for-primary-tonsillar-lymphoma
#11
Yun Hee Lee, Seok Goo Cho, Seung Eun Jung, Sung Hoon Kim, Joo Hyun O, Gyeong Sin Park, Suk Woo Yang, In Seok Lee, Chin Kook Rhee, Byung Ock Choi
PURPOSE: Although each Waldeyer's ring sub-site is considered an independent prognostic factor, few studies have assessed the prognosis and treatment of tonsillar lymphoma. Treatment outcomes were analyzed in patients with primary tonsillar lymphoma who were treated with chemotherapy and radiotherapy (RT). MATERIALS AND METHODS: Nineteen patients with diffuse large B-cell lymphoma were evaluated, with a median follow-up of 53 months. Age, sex, and histology, amongst other factors, were reviewed...
December 2016: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28024511/-clinico-pathologic-characteristics-of-adult-patients-with-atypical-infectious-mononucleosis
#12
Ya-Ping Yu, Ping Song, Zhi-Ming An, Xiao-Gang Zhou, Feng Li, Li-Ping Wang, Jian-Gang Mei, Yong-Ping Zhai
OBJECTIVE: To investigate the clinicopathologic characteristics of adult patients with atypical infectious mononucleosis(IM). METHODS: From January 2003 to December 2013, a total of 5 cases of atypical IM misdiagnosed as lymphoma were selected, and the clinico-pathological characteristics and efficacy of treatment were analyzed. Biopsy of lymph node or tonsil was performed to evaluate the possibility of lymphoma. Peripheral blood EBV antibody and EBV-DNA were examined by ELISA and real-time fluorescence quantitative PCR, respectively...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28008151/tonsillar-cd56brightnkg2a-nk-cells-restrict-primary-epstein-barr-virus-infection-in-b-cells-via-ifn-%C3%AE
#13
Aurelia Jud, Monika Kotur, Christoph Berger, Claudine Gysin, David Nadal, Anna Lünemann
Natural killer (NK) cells constitute the first line of defense against viruses and cancers cells. Epstein-Barr virus (EBV) was the first human virus to be directly implicated in carcinogenesis, and EBV infection is associated with a broad spectrum of B cell lymphomas. How NK cells restrict EBV-associated oncogenesis is not understood. Here, we investigated the efficacies and mechanisms of distinct NK cell subsets from tonsils, the portal of entry of EBV, in limiting EBV infection in naïve, germinal center-associated and memory B cells...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/27933753/mass-cytometry-of-follicular-lymphoma-tumors-reveals-intrinsic-heterogeneity-in-proteins-including-hla-dr-and-a-deficit-in-nonmalignant-plasmablast-and-germinal-center-b-cell-populations
#14
Cara Ellen Wogsland, Allison Rae Greenplate, Arne Kolstad, June Helen Myklebust, Jonathan Michael Irish, Kanutte Huse
BACKGROUND: Follicular lymphoma (FL) is an indolent non-Hodgkin lymphoma that has a risk of transformation to more aggressive lymphoma. Relatively little is known about the nonmalignant B-cell and T-cell subset composition within the tumor microenvironment and whether altered phenotypes are associated with patterns of lymphoma B-cell heterogeneity. METHODS: Two mass cytometry (CyTOF) panels were designed to immunophenotype B and T cells in FL tumors. Populations of malignant B cells, nonmalignant B cells, and T cells from each FL tumor were identified and their phenotypes compared to B and T cells from healthy human tonsillar tissue...
January 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27833988/tonsillar-lymphoma-masquerading-as-obstructive-sleep-apnea-pediatric-case-report
#15
Corneliu Toader, MioriŢa Toader, Alina Stoica, Gabriel Pop, Alina Oprea, Anca Simona Constantin, Liviu Niculescu, Iolanda Cristina Vivisenco, Mircea Stelian Drăghici, Andrei Osman, Carmen Aurelia Mogoantă
The commonest cause of head and neck malignancy in pediatric patients is lymphoma. A particular case is the tonsillar lymphoma. Even though unilateral tonsillar enlargement represents an ominous sign for neoplasia, clinical manifestations vary and are non-specific. Therefore, a delayed diagnosis is performed which compromises optimal therapy and hinders the prognosis. We present the case of a 5-year-old boy who was initially diagnosed with obstructive sleep apnea, without reported systemic complaints. Asymmetric tonsillar hypertrophy created the premises for performing a tonsillectomy to rule out malignancy...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27805921/c-cbl-e3-ubiquitin-ligase-expression-increases-across-the-spectrum-of-benign-and-malignant-t-cell-skin-diseases
#16
Katrin A Salva, Margo J Reeder, Rita Lloyd, Gary S Wood
Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Immunohistochemical staining with anti-c-CBL antibody was performed on lesional biopsies from a total of 65 patients with atopic dermatitis, allergic contact dermatitis, pityriasis rosea, psoriasis vulgaris, lichen planus, mycosis fungoides (MF)/Sézary syndrome (SS) as well as on tonsil tissue from 5 individuals and on 5 human CTCL cell lines...
October 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27408379/bilateral-tonsillar-enlargement-as-a-first-manifestation-of-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-with-an-unusual-interfollicular-pattern-of-infiltration
#17
Rajan Duggal, Alka Rana, Ashok Vaid, Nitin Sood, Kumud Kumar Handa
Tonsillar lymphoma usually presents as unilateral or bilateral enlargement or as an ulcerative or fungating lesions. Most lymphomas that involve the tonsils are diffuse large B-cell lymphomas and primary low grade lymphomas are exceptional. We report a case of primary B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) affecting tonsils with interfollicular pattern of infiltration in a 54-year-old female who clinically presented with bilateral tonsillar enlargement, sore throat, dysphagia and respiratory difficulty, unresponsive to the conservative treatment...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27386809/velopharyngeal-incoordination-caused-by-phenytoin-induced-toxicity
#18
Chang Ho Hwang
Phenytoin induces lymphoid proliferation, resulting in complications that can range from tissue hyperplasia to lymphoma. Some of the complications resolve spontaneously after drug discontinuation. This report describes for the first time a case of dysphagia with lack of velopharyngeal coordination and nasopharyngeal reflux combined with massive palatine tonsillar hypertrophy. The condition did not develop before phenytoin administration, was induced by phenytoin, and spontaneously resolved upon drug discontinuation...
February 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27356578/differential-expression-of-cd150-slamf1-in-normal-and-malignant-b-cells-on-the-different-stages-of-maturation
#19
I M Gordiienko, L M Shlapatska, L M Kovalevska, S P Sidorenko
UNLABELLED: Within B-cell lineage cell surface receptor CD150/SLAMF1 is broadly expressed starting from pre-B cells with upregulation toward plasma cells. However, expression of CD150 is rather limited on the surface of malignant B cells with the block of differentiation at the different stages of maturation. The aim of our work was to explore CD150 expression both on protein and mRNA levels with the emphasis on CD150 isoforms in malignant B-cell lines at the different stages of maturation in comparison with their normal B cell counterparts...
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/26903604/immunoproliferative-small-intestinal-disease-associated-with-overwhelming-polymicrobial-gastrointestinal-infection-with-transformation-to-diffuse-large-b-cell-lymphoma
#20
Evan C Ewers, Robert L Sheffler, James Wang, Viseth Ngauy
Immunoproliferative small intestinal disease (IPSID) is an extra-nodal B-cell lymphoma most commonly described in the Mediterranean, Africa, and Asia. It is associated with poverty and poor sanitation, and is rarely encountered in developed countries. A 26-year-old previously healthy, Marshallese male was transferred to our facility with a 6-month history of watery diarrhea, weakness, and cachexia refractory to multiple short courses of oral antibiotics. Stool cultures grew Campylobacter jejuni and Vibrio fluvialis...
May 4, 2016: American Journal of Tropical Medicine and Hygiene
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