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JOURNAL ARTICLE
Georgia Mackay, Alina Rankin, Sheneen Meghji, Craig McCaffer
BACKGROUND: Paediatric tonsillar lymphoma (TL) is a rare diagnosis. Historically, the presence of clinical features such as tonsillar asymmetry, grossly abnormal tonsil appearance and cervical lymphadenopathy raise concern for this diagnosis. Tonsillar asymmetry is considered to be the most concerning clinical feature; however, asymmetry is often apparent due to differences in depth or shape of tonsillar fossa and tonsillar pillars, rather than a true difference in volume. There is debate whether a tonsillectomy is required in all cases of tonsil asymmetry to exclude lymphoma, and what clinical features should raise concern...
April 12, 2024: New Zealand Medical Journal
#2
JOURNAL ARTICLE
Lauren Fang, Richard Simman, Lauren Workman, Samar Ayoub, Camille Bratton
OBJECTIVE: Malignant wounds develop when neoplastic cells invade the skin either locally or by lymphatic and haematogenous spread. They can present as hard-to-heal wounds and underlying causes include: primary skin cancer; metastasis of extracutaneous primary malignancy; malignant transformation of a hard-to-heal wound; iatrogenic injury; and cutaneous forms of cancers of non-skin origin. High clinical suspicion for a malignant wound should be confirmed with skin biopsy. The aim of this case series is to highlight a combination of both clinically clear cutaneous malignancies and not-so-obvious wounds caused by malignancy...
February 2, 2024: Journal of Wound Care
#3
JOURNAL ARTICLE
Ramon Massoni-Badosa, Sergio Aguilar-Fernández, Juan C Nieto, Paula Soler-Vila, Marc Elosua-Bayes, Domenica Marchese, Marta Kulis, Amaia Vilas-Zornoza, Marco Matteo Bühler, Sonal Rashmi, Clara Alsinet, Ginevra Caratù, Catia Moutinho, Sara Ruiz, Patricia Lorden, Giulia Lunazzi, Dolors Colomer, Gerard Frigola, Will Blevins, Lucia Romero-Rivero, Víctor Jiménez-Martínez, Anna Vidal, Judith Mateos-Jaimez, Alba Maiques-Diaz, Sara Ovejero, Jérôme Moreaux, Sara Palomino, David Gomez-Cabrero, Xabier Agirre, Marc A Weniger, Hamish W King, Lucy C Garner, Federico Marini, Francisco Javier Cervera-Paz, Peter M Baptista, Isabel Vilaseca, Cecilia Rosales, Silvia Ruiz-Gaspà, Benjamin Talks, Keval Sidhpura, Anna Pascual-Reguant, Anja E Hauser, Muzlifah Haniffa, Felipe Prosper, Ralf Küppers, Ivo Glynne Gut, Elias Campo, José Ignacio Martin-Subero, Holger Heyn
Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of immunological defense against inhaled or ingested pathogens. We generated an atlas of the human tonsil composed of >556,000 cells profiled across five different data modalities, including single-cell transcriptome, epigenome, proteome, and immune repertoire sequencing, as well as spatial transcriptomics. This census identified 121 cell types and states, defined developmental trajectories, and enabled an understanding of the functional units of the tonsil...
February 13, 2024: Immunity
#4
JOURNAL ARTICLE
Emilio-Manuel Páez-Guillán, Joaquín Campos-Franco, Rosario Alende, Arturo González-Quintela
BACKGROUND AND AIM: The use of systemic corticosteroids during Epstein-Barr virus (EBV)-induced infectious mononucleosis is a controversial but widespread practice. We aimed to investigate the frequency of complications in adolescents and adults with infectious mononucleosis in relation to the use of corticosteroids. METHODS: We reviewed the clinical records of 396 patients admitted to the hospital with infectious mononucleosis (52.0% male; median age, 19 years; range, 15-87 years), with a focus on both short-term (infectious and non-infectious) and long-term (hematological malignancies) complications in relation to corticosteroid use...
January 11, 2024: Enfermedades infecciosas y microbiologia clinica
#5
JOURNAL ARTICLE
Priyanka Mishra, Manoj Prashar, Nidhin Rehman, Anamika Sinha, Deep K Raman
BACKGROUND: Primary extranodal lymphomas (pENL) are lymphomas with minimal nodal involvement and dominant extranodal disease. We aimed to study the prevalence and clinicopathological characteristics of pENL presenting at our center over 5 years from January 2015 to January 2020. METHODS: This is a cross-sectional study of pENL patients in which relevant clinical and laboratory data was collected including demography, site, stage, international prognostic index-revised, imaging findings, hematological, and biochemical parameters and comorbidities including underlying immunodeficiency...
April 17, 2023: Indian Journal of Cancer
#6
JOURNAL ARTICLE
Seraphina Key, Clemente Chia, Matthew Magarey, Benjamin Dixon
BACKGROUND: Utilization of positron emission tomography/computed tomography (PET/CT) with fluorodeoxyglucose is increasing in use for a variety of indications, including surveillance of cancer patients. There is a paucity of evidence pertaining to the significance of incidental PET-avid oropharyngeal lesions. This study aims to examine the clinical and radiological features of these incidental oropharyngeal lesions in patients undergoing PET for indications other than head and neck cancer...
December 19, 2023: ANZ Journal of Surgery
#7
JOURNAL ARTICLE
Hitoshi Ichikawa, Keiko Ohno, Emi Irie, Kazuhiro Kashiwagi
No abstract text is available yet for this article.
2023: Internal Medicine
#8
JOURNAL ARTICLE
Allie M Ottinger, Roshansa Singh, Dong Chen, Kourosh Parham
Unilateral tonsillar enlargement is a common indication for tonsillectomy, but there are varying rates of malignancy among tonsils removed for asymmetry and a lack of clear guidelines for management within the literature. Lymphoma of the palatine tonsils is among the concerns leading to tonsillectomy, but chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) of the tonsil is rare. We report a case of primary CLL/SLL of the palatine tonsil in a 51-year-old gentleman who presented with tonsillar asymmetry and obstructive sleep apnea (OSA) but lacked signs and symptoms suspicious for malignancy, including lymphadenopathy and "B-symptoms...
November 24, 2023: Ear, Nose, & Throat Journal
#9
JOURNAL ARTICLE
Agil Babu, Manish Sahni, Kamal Kishor Lakhera, Pinakin Patel, Suresh Singh
Spindle cell neoplasm of the tonsil are rare (Minami et al. in Am J Otolaryngol 29(2):123-125, 2008) and can be difficult to diagnose due to their non-specific clinical presentation and histological characteristics (Su et al. in J Chin Med Assoc 69(10):478-483, 2006). Differential diagnoses include lymphoma and squamous cell carcinoma (Hyams in Clin Otolaryngol Allied Sci 3(2):117-126, 1978). Oropharyngeal spindle cell neoplasms were more likely to occur in the tongue base and tonsil (58%) (Gerry et al. in Ann Otol Rhinol Laryngol 123(8):576-583, 2014)...
December 2023: Indian Journal of Otolaryngology and Head and Neck Surgery
#10
Fatima Alkhyeli, Abdollah Bahaeddin
BACKGROUND: Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a rare benign disease that presents as cervical lymphadenopathy and fever. CASE PRESENTATION: A 25-year-old South Asian female dentist, recently married, presented to our emergency department due to two weeks of fever, sore throat, swollen neck, and cough. The patient initially presented to a private clinic and was prescribed antibiotics on two visits. On physical examination, her neck was swollen with palpable and tender right posterior and submandibular lymph nodes...
August 2023: Curēus
#11
JOURNAL ARTICLE
Ivana Spasevska, Ankush Sharma, Chloé B Steen, Sarah E Josefsson, Yngvild N Blaker, Arne Kolstad, Even H Rustad, Saskia Meyer, Kathrine Isaksen, Stalin Chellappa, Kushi Kushekhar, Klaus Beiske, Mette S Førsund, Signe Spetalen, Harald Holte, Bjørn Østenstad, Marianne Brodtkorb, Eva Kimby, Johanna Olweus, Kjetil Taskén, Aaron M Newman, Susanne Lorenz, Erlend B Smeland, Ash A Alizadeh, Kanutte Huse, June H Myklebust
Tumor-infiltrating regulatory T cells (Tregs) contribute to an immunosuppressive tumor microenvironment. Despite extensive studies, the prognostic impact of tumor-infiltrating Tregs in B-cell non-Hodgkin lymphomas (B-NHLs) remains unclear. Emerging studies suggest substantial heterogeneity in the phenotypes and suppressive capacities of Tregs, emphasizing the importance of understanding Treg diversity and the need for additional markers to identify highly suppressive Tregs. Here, we applied single-cell RNA sequencing and T-cell receptor sequencing combined with high-dimensional cytometry to decipher the heterogeneity of intratumoral Tregs in diffuse large B-cell lymphoma and follicular lymphoma (FL), compared with that in nonmalignant tonsillar tissue...
December 12, 2023: Blood Advances
#12
JOURNAL ARTICLE
Andrew Spencer, Anna Kalff, Jake Shortt, Hang Quach, Craig Wallington-Gates, John Reynolds, Patricia Walker, Simon J Harrison, Rosanne Dunn, Cameron Wellard
KappaMab (KM; formerly MDX-1097) is a monoclonal antibody specific for the kappa myeloma antigen (KMA), a cell-surface antigen expressed on malignant plasma cells in kappa-restricted multiple myeloma (κMM), some lymphomas, occasional tonsillar B cells and in vitro activated B cells, but not on normal B cells in bone marrow. Phase I/IIa studies of single-agent KM confirmed a favourable toxicity profile and evidence of anti-myeloma activity. Ex-vivo studies demonstrating upregulation of KMA by lenalidomide, and enhanced effector-cell cytotoxicity provided the rationale for this phase IIb study where KM or KM in combination with lenalidomide and dexamethasone (KM-Rd) was administered in relapsed, refractory κMM patients...
August 2023: British Journal of Haematology
#13
Tyler J Ostrowski, Maria Faraz, Matthew Holdaway, Anne Chen, Neil Gildener-Leapman
Syphilis is a bacterial infection commonly transmitted by sexual contact. It has variable manifestations and can mimic other disease processes or infections. This report presents the case of a 48-year-old HIV-positive male who was referred to our head and neck clinic with complaints of tonsillar hypertrophy and ulceration accompanied by a one-month history of ipsilateral cervical lymphadenopathy and facial pain in the setting of recent unexplained weight loss and abnormal radiographic imaging of the neck. In-office tonsillar biopsy and fine-needle aspiration of a neck mass revealed a non-diagnostic atypical lymphoid proliferation...
April 2023: Curēus
#14
JOURNAL ARTICLE
Megan Turner, Felicity Craighead, Joseph Donald MacKenzie, Avinash Aujayeb
BACKGROUND: Local anaesthetic thoracoscopy (LAT) can be a vital procedure for diagnosis of unexplained pleural effusions. Traditionally, poudrage for pleurodesis and insertion of a large bore drain necessitated admission. There has been a shift towards performing LAT as a day case procedure with indwelling pleural catheter (IPC) insertion. This was advocated during the COVID pandemic by the British Thoracic Society (BTS). To determine the feasibility of such pathways, continuous evaluations are required...
March 15, 2023: Medical Sciences: Open Access Journal
#15
JOURNAL ARTICLE
Kohei Hasegawa, Kenya Murata, Yoshihiko Ogawa
Syphilis is surging in Japan and worldwide among both homosexual and heterosexual individuals. Diagnosis can be challenging because syphilis is "the great imitator" and clinical manifestations are highly variable. Oral manifestations of syphilis are usually seen in the second stage and the primary syphilis in the oral cavity is rare. We describe a heterosexual man with isolated tonsillar lesions initially misdiagnosed as pharyngeal lymphoma and subsequently diagnosed as primary syphilis. Clinicians should be aware that isolated oropharyngeal involvement can occur in the primary syphilis and can mimic a neoplasm...
March 28, 2023: International Journal of STD & AIDS
#16
JOURNAL ARTICLE
Mélanie Langlois, Salim Bounou, Michel J Tremblay, Benoit Barbeau
Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis. Its tropism is known to be broad in cultured cell lines, while in vivo data support a more selective transmission toward CD4+ T cells and the limited targeting of other hematopoietic cell types. An essential condition for HTLV-1 infection is cell-to-cell contact, to which both virological synapse and viral biofilm have been suggested to strongly contribute...
January 24, 2023: Pathogens
#17
JOURNAL ARTICLE
Samuel Bosco, Tanner Lyons, Melanie Shpigel, Corrado Minimo, Rehka Bhat, Seth Zwillenberg, Amit Bhojwani
A tonsillar mass in a young patient with no medical issues routinely presents as an infectious process. Practitioners must maintain a broad differential if diagnostic testing does not support an infection. Neoplasm must be excluded. Otolaryngologists must consider malignancies other than squamous cell carcinoma, the most common oropharyngeal malignancy, and lymphoma. Rare tumors, such as sarcomas, must also be considered. Otolaryngologists must be familiar with the proper management of rare oropharyngeal malignancies...
January 12, 2023: Ear, Nose, & Throat Journal
#18
Shibo Song, Xiaolong Feng, Xudong Liu, Guiqi Wang, Liyan Xue
Esophageal submucosal tumors are rare, but their pathological types are diverse. In addition to the relatively common leiomyomas, some rare submucosal lesions are occasionally reported. Waldeyer's ring is described as a unique subtype of mucosa-associated lymphoid tissue, located in the naso-oropharynx. Studies have reported that Waldeyer's ring is the most common site of primary extranodal lymphoma in the head and neck. Interestingly, we encountered an esophageal submucosal tumor-like lesion similar to the tonsillar structures of Waldeyer's ring...
December 7, 2022: Medicina
#19
JOURNAL ARTICLE
İlke Kara, Saime Ramadan, Evrim Şenkal, Pelin Koçdor
Postoperative routine pathologic evaluation of tonsillectomy and adenoidectomy specimens rarely reveals a diagnosis of malignancy. The object of this case report is to highlight this rare clinical occurrence. A 4-year-old boy presented with symptoms of sleep-disordered breathing and had a history of recurrent tonsillitis. Physical examination revealed adenoid hypertrophy and Brodsky Grade 1 bilateral tonsillar hypertrophy. The patient underwent adenoidectomy and tonsillectomy. The adenoids were found to be MAGS Grade 4 (Modified Adenoid Grading System) hypertrophic causing 100% obstruction...
December 7, 2022: International Journal of Surgical Pathology
#20
JOURNAL ARTICLE
Kanutte Huse, Baoyan Bai, Vera I Hilden, Lise K Bollum, Thea K Våtsveen, Ludvig A Munthe, Erlend B Smeland, Jonathan M Irish, Sébastien Wälchli, June H Myklebust
The BCR consists of surface-bound Ig and a heterodimeric signaling unit comprised of CD79A and CD79B. Upon cognate Ag recognition, the receptor initiates important signals for B cell development and function. The receptor also conveys Ag-independent survival signals termed tonic signaling. Although the requirement of a CD79A/CD79B heterodimer for BCR complex assembly and surface expression is well established based on mice models, few studies have investigated this in human mature B cells. In this study, we found that human tonsillar B cells with high surface expression of IgM or IgG had potentiated BCR signaling compared with BCRlow cells, and high IgM expression in germinal center B cells was associated with reduced apoptosis...
November 15, 2022: Journal of Immunology
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