keyword
MENU ▼
Read by QxMD icon Read
search

Lipopolysaccharide

keyword
https://www.readbyqxmd.com/read/28350851/alcohol-related-changes-in-the-intestinal-microbiome-influence-neutrophil-infiltration-inflammation-and-steatosis-in-early-alcoholic-hepatitis-in-mice
#1
Patrick P Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V Ward, Gyongyi Szabo
BACKGROUND: Alcohol-induced intestinal dysbiosis disrupts homeostatic gut-liver axis function and is essential in the development of alcoholic liver disease. Here, we investigate changes in enteric microbiome composition in a model of early alcoholic steatohepatitis and dissect the pathogenic role of intestinal microbes in alcohol-induced liver pathology. MATERIALS AND METHODS: Wild type mice received a 10-day diet that was either 5% alcohol-containing or an isocaloric control diet plus a single binge...
2017: PloS One
https://www.readbyqxmd.com/read/28350760/involvement-of-hsp70-and-ho-1-in-the-protective-effects-of-raloxifene-on-multiple-organ-dysfunction-syndrome-by-endotoxemia-in-ovariectomized-rats
#2
Hsin-Hsueh Shen, Shieh-Yang Huang, Pao-Yun Cheng, Yen-Ju Chu, Shu-Ying Chen, Kwok-Keung Lam, Yen-Mei Lee
OBJECTIVE: Accumulating evidence demonstrates that raloxifene, a selective estrogen receptor modulator, possesses anti-inflammatory action. This study evaluates the preventive effects of long-term treatment of raloxifene on acute inflammation and multiple organ dysfunction syndrome (MODS) in ovariectomized (OVX) rats with endotoxemia and its underlying mechanism of action. METHODS: Adult female rats were OVX bilaterally to induce estrogen insufficiency. OVX rats were administered with raloxifene (1 mg/kg, gavage, once daily) for 8 weeks, beginning 1 week after surgery, followed by induction of sepsis via intravenous infusion of lipopolysaccharides (LPS; 30 mg/kg) for 4 hours...
March 27, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28350536/anti-inflammatory-effects-and-anti-oxidant-capacity-of-myrathius-arboreus-cecropiaceae-in-experimental-models
#3
Oluwafemi Gabriel Oluwole, Olufunmilayo Ologe, Akinyinka Alabi, Ganiyu Tunde Yusuf, Solomon Umukoro
BACKGROUND: Inflammation is involved in various diseases; search for safe treatments is warranted. Anti-inflammatory effects of ethanol extract of Myrathius arboreus (EEMa) were studied in carrageenan-induced model, formaldehyde sub-acute-induced model, and in 48 h lipopolysaccharide-induced air pouch model of inflammation. EEMa membrane-stabilizing activities and anti-oxidant capacity were determined in vitro. METHODS: In the carrageenan model EEMa (125, 250, or 500 mg/kg), indomethacin (5 mg/kg), or vehicle 3 mL/kg was administered orally in rats (n=5)...
March 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28346799/activation-of-macrophages-by-lipopolysaccharide-for-assessing-the-immunomodulatory-property-of-biomaterials
#4
Shengwei Han, Zetao Chen, Pingping Han, Qingang Hu, Yin Xiao
The design paradigm of biomaterials has been changed to ones with favorable immunomodulatory effects, indicating the importance of accurately evaluating the immunomodulatory properties of biomaterials. Among all the immune cells macrophages receive most attention, due to their plasticity and multiple roles in the materials and host interactions, and thereby become model immune cells for the evaluation of immunomodulatory properties of biomaterials in many studies. Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFα), interleukin (IL)-1, and IL-6...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28346507/olive-oil-bioactives-protect-pigs-against-experimentally-induced-chronic-inflammation-independently-of-alterations-in-gut-microbiota
#5
Martin Liehr, Alessandro Mereu, Jose Javier Pastor, Jose Carlos Quintela, Stefanie Staats, Gerald Rimbach, Ignacio Rodolfo Ipharraguerre
Subclinical chronic inflammation (SCI) is associated with impaired animal growth. Previous work has demonstrated that olive-derived plant bioactives exhibit anti-inflammatory properties that could possibly counteract the growth-depressing effects of SCI. To test this hypothesis and define the underlying mechanism, we conducted a 30-day study in which piglets fed an olive-oil bioactive extract (OBE) and their control counterparts (C+) were injected repeatedly during the last 10 days of the study with increasing doses of Escherichia coli lipopolysaccharides (LPS) to induce SCI...
2017: PloS One
https://www.readbyqxmd.com/read/28346367/transplantation-of-menstrual-blood-derived-mesenchymal-stem-cells-promotes-the-repair-of-lps-induced-acute-lung-injury
#6
Bingyu Xiang, Lu Chen, Xiaojun Wang, Yongjia Zhao, Yanling Wang, Charlie Xiang
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity and mortality. Menstrual blood-derived stem cells (MenSCs) have been shown to be good therapeutic tools in diseases such as ovarian failure and cardiac fibrosis. However, relevant studies of MenSCs in ALI have not yet proceeded. We hypothesized that MenSC could attenuate the inflammation in lipopolysaccharide (LPS)-induced ALI and promote the repair of damaged lung. ALI model was induced by LPS in C57 mice, and saline or MenSCs were administered via tail vein after four hours...
March 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28346354/anti-inflammatory-properties-of-irisin-mediator-of-physical-activity-are-connected-with-tlr4-myd88-signaling-pathway-activation
#7
Agnieszka Irena Mazur-Bialy, Ewa Pocheć, Marcin Zarawski
Irisin, an adipomiokine known as a mediator of physical activity, induces the browning of adipose tissue and it has potentially protective properties in the development of obesity-related states, such as insulin resistance, arteriosclerosis, and type 2 diabetes. Despite numerous studies conducted on this factor, still little is known about its impact on the functioning of immunocompetent cells, but its potential anti-inflammatory properties were previously suggested. In the current study we investigated the role of irisin (0-100 nM) in the downstream pathway activation of Toll-like receptor 4 (TLR4) in RAW 264...
March 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28345644/vitamin-d-both-facilitates-and-attenuates-the-cellular-response-to-lipopolysaccharide
#8
Ling Chen, Mathew Suji Eapen, Graeme R Zosky
Vitamin D has a range of non-skeletal health effects and has been implicated in the response to respiratory infections. The aim of this study was to assess the effect of vitamin D on the response of epithelial cells, neutrophils and macrophages to lipopolysaccharide (LPS) stimulation. BEAS-2B cells (airway epithelial cell line) and primary neutrophils and macrophages isolated from blood samples were cultured and exposed to LPS with and without vitamin D (1,25(OH)2D). The production of IL-6, IL-8, IL-1β and TNF-α of all cells and the phagocytic capacity of neutrophils and macrophages to E...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345549/sub-anesthesia-dose-of-isoflurane-in-60-oxygen-reduces-inflammatory-responses-in-experimental-sepsis-models
#9
Yi Huang, Xiao-Xia Wang, Dong-Dong Sun, Ze-Xin Zhang, Wan-Wan Yang, Tian Shao, Han Han, Er-Fei Zhang, Zhong-Shu Pu, Zuo-Xu Hou, Hai-Long Dong, Li-Ze Xiong, Li-Chao Hou
BACKGROUND: Sepsis is a major cause of mortality in Intensive Care Units. Anesthetic dose isoflurane and 100% oxygen were proved to be beneficial in sepsis; however, their application in septic patients is limited because long-term hyperoxia may induce oxygen toxicity and anesthetic dose isoflurane has potential adverse consequences. This study was scheduled to find the optimal combination of isoflurane and oxygen in protecting experimental sepsis and its mechanisms. METHODS: The effects of combined therapy with isoflurane and oxygen on lung injury and sepsis were determined in animal models of sepsis induced by cecal ligation and puncture (CLP) or intraperitoneal injection of lipopolysaccharide (LPS) or zymosan...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345525/tolerance-of-monocytes-and-macrophages-in-response-to-bacterial-endotoxin
#10
Ewelina Wiśnik, Ewa Pikus, Piotr Duchnowicz, Maria Koter-Michalak
Monocytes belong to myeloid effector cells, which constitute the first line of defense against pathogens, also called the nonspecific immune system and play an important role in the maintenance of tissue homeostasis. In response to stimulation, monocytes differentiate into macrophages capable of microorganism phagocytosis and secrete factors that play a key role in the regulation of immune responses. However excessive exposure of monocytes/macrophages to the lipopolysaccharide (LPS) of Gram negative bacteria leads to the acquisition of immune tolerance by these cells...
March 7, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28345393/inhibitory-effects-of-3%C3%AE-hydroxy-lup-20-29-en-23-28-dioic-acid-on-lipopolysaccharide-induced-tnf-%C3%AE-il-1%C3%AE-and-the-high-mobility-group-box-1-release-in-macrophages
#11
Xiang-Qian Liu, Qin-Peng Zou, Jian-Jun Huang, Chang-Soo Yook, Wan-Kyunn Whang, Hyeong-Kyu Lee, Ok-Kyoung Kwon
We investigated the anti-inflammatory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid (HLEDA)-a lupane-type triterpene isolated from leaves of Acanthopanax gracilistylus W. W.Smith (AGS), as well as the underlying molecular mechanisms in lipopolysaccharide (LPS)-induced RAW264.7 cells. Our results demonstrated that HLEDA concentration-dependently reduced the production of nitric oxide (NO), significantly suppressed LPS-induced expression of TNF-α and IL-1β at the mRNA and protein levels in RAW264...
March 27, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28344826/impact-of-bone-marrow-derived-mesenchymal-stem-cells-on-remodeling-the-lung-injury-induced-by-lipopolysaccharides-in-mice
#12
Mouchira M Mohi El-Din, Laila A Rashed, Mohi A Mahmoud Haridy, Atef Mohamed Khalil, Mohamed A Mohamed Albadry
AIM: This study evaluated the potential of bone marrow derived mesenchymal stem cells (MSCs) to regulate cytokines and remodel the lung induced by lipopolysaccharide (LPS; O-antigen). MATERIALS & METHODS: A group of mice (n = 21) was inoculated intraperitoneally with one dose 0.1 ml containing 0.025 mg LPS/mouse, and another treated intravenously with one dose of labeling bone marrow derived MSCs at 7.5 × 10(5) cell/mouse 4 h after LPS injection. All animals were sacrificed on the 1st, 7th and 14th days post-injection...
March 2017: Future Science OA
https://www.readbyqxmd.com/read/28344491/effect-of-aster-tataricus-on-production-of-inflammatory-mediators-in-lps-stimulated-rat-astrocytoma-cell-line-c6-and-thp-1-cells
#13
Hong-Tao Zhang, Miao Tian, Qiao-Wei He, Nan Chi, Chun-Ming Xiu, Yun-Bo Wang
Neuroinflammation is the commonest cause of neurodegenerative diseases such as Alzheimer's disease. Present investigation evaluates the inhibitory effect of ethanolic root extract of Aster tataricus (AS) on inflammatory mediators production in lipopolysaccharide (LPS) stimulated C6 cells. C6 cells were treated with AS (20 and 40 mg/kg) and nimesulide (NSL, 1.5 μg/ml) for 1 day. Thereafter various parameters such as production of ROS, release of nitrite, MDA, glutathione level and NF-κB translocation were estimated in C6 cell lines...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28344212/age-dependent-effects-of-prenatal-dexamethasone-exposure-on-immune-responses-in-male-rats
#14
Ming-Yi Chou, Li-Tung Huang, You-Lin Tain, Ho-Chang Kuo, Mao-Meng Tiao, Jiunn-Ming Sheen, Chih-Cheng Chen, Pi-Lien Hung, Kai-Sheng Hsieh, Hong-Ren Yu
Prenatal glucocorticoid therapy is indicated in preterm delivery to prevent respiratory distress. This study was designed to evaluate the age-dependent effects of prenatal dexamethasone (DEX) therapy on the immune system using a rat model. Pregnant Sprague-Dawley rats received an intraperitoneal injection of DEX (0.1 mg/kg/day) or saline (VEH) over gestational days 14-20. Male offspring were sacrificed at postnatal day 7 (D7; infant stage), D120 (young adult stage), and D180 (adult stage) for evaluation of leukocyte subsets and isolation of splenocytes...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28344171/lipopolysaccharide-induced-interleukin-6-production-is-mediated-through-activation-of-erk-1-2-p38-mapk-mek-and-nf%C3%AE%C2%BAb-in-chicken-thrombocytes
#15
C Winkler, F Ferdous, M Dimmick, T Scott
Thrombocytes express Toll-like receptor 4 and apparently use both mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) pathways for nuclear signaling. However, it is not well known if the same enzyme systems found in mammalian cells are fully functional in chickens. Therefore, kinase inhibitors were used with thrombocytes to block kinases in lipopolysaccharide (LPS) stimulated cells to determine if interleukin (IL)-6 expression and production would be diminished...
March 23, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28344169/the-identification-characterization-and-function-of-two-trems-genes-in-chinese-yangzhou-goose-anas-cygnoides
#16
Huanxi Zhu, Xiaoqian Liu, Jie Du, Mingming Lei, Shijia Ying, Junshu Yan, Jianning Yu, Zhendan Shi, Hui Li
Triggering receptor expressed on myeloid cells (TREM) is a cell-surface receptor primarily expressed on macrophages. Here, two novel TREM genes, AcTREM1 and AcTREM2, were identified from Anas cygnoides. AcTREM1 cDNA contained a putative signal peptide, two IG domains, and a transmembrane domain. The deduced AcTREM2 sequence also contained a signal peptide, an IG domain, and a transmembrane domain. qRT-PCR, fluorescence in situ hybridization, and immunofluorescence experiments showed that AcTREM1 and AcTREM2 were mainly expressed in the liver and spleen, and both genes and proteins were mainly distributed in cytoplasm...
March 23, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28344161/cross-resistance-to-human-cationic-antimicrobial-peptides-and-to-polymyxins-mediated-by-the-plasmid-encoded-mcr-1
#17
Jan Dobias, Laurent Poirel, Patrice Nordmann
OBJECTIVES: To evaluate whether acquired resistance to cationic antimicrobial peptides (CAMP) group molecules, being normal components of the human immune system, may select co-resistance to antibiotic peptides such as polymyxins, considering they share the same mechanism of action. We aimed to evaluate strains producing the recently identified plasmid-encoded polymyxin resistance determinant MCR-1, which is a phosphoethanolamine transferase that modifies the lipopolysaccharide structure of Gram-negative bacteria...
March 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28344123/effects-of-campylobacter-jejuni-lipopolysaccharide-on-axonal-injury-in-the-spinal-cord-in-rats
#18
Xusheng Li, Haohao Chen, Hongmiao Tao, Ye Hu, Hongqiang Lou
To explore the effects of Campylobacter jejuni lipopolysaccharide (Cj-LPS) on axonal injury in the spinal cord. Wistar rats were divided into the control (NC) group, model group (Cj-LPS), and LPS antibody group (Anti-LPS). Rats in the NC group were injected with a mixture of normal saline and complete Freund's adjuvant (CFA) while those in Cj-LPS group were injected with Cj-LPS, composed of LPS, CFA, and saline. Rats were sacrificed at 4th week and 6th week after injection, and hematoxylin and eosin (HE) staining was performed on the spinal cord sections...
March 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28343295/identification-of-sphingosine-1-phosphate-receptor-subtype-1-s1p1-as-a-pathogenic-factor-in-transient-focal-cerebral-ischemia
#19
Bhakta Prasad Gaire, Chi-Ho Lee, Arjun Sapkota, Sang Yeul Lee, Jerold Chun, Hee Jun Cho, Tae-Gyu Nam, Ji Woong Choi
Medically relevant roles of receptor-mediated sphingosine 1-phosphate (S1P) signaling have become a successful or promising target for multiple sclerosis or cerebral ischemia. Animal-based proof-of-concept validation for the latter is particularly through the neuroprotective efficacy of FTY720, a non-selective S1P receptor modulator, presumably via activation of S1P1. In spite of a clear link between S1P signaling and cerebral ischemia, it remains unknown whether the role of S1P1 is pathogenic or neuroprotective...
March 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28342969/structural-and-genetic-characterization-of-the-o-antigen-of-enterobacter-cloacae-c5529-related-to-the-o-antigen-of-e-%C3%A2-cloacae-g3054
#20
Runhua Han, Andrei V Perepelov, Yuanyuan Wang, Andrei V Filatov, Min Wang, Alexander S Shashkov, Lei Wang, Yuriy A Knirel
On mild acid degradation of the lipopolysaccharide of Enterobacter cloacae C5529, the O-polysaccharide chain was cleaved at the linkages of 5,7-diacetamido-3,5,7,9-tetradeoxy-l-glycero-l-manno-non-2-ulosonic acid (di-N-acetylpseudaminic acid, Psep5Ac7Ac). The resultant oligosaccharide and an alkali-treated lipopolysaccharide were studied by sugar analysis along with (1)H and (13)C NMR spectroscopy, and the following structure of the tetrasaccharide repeating unit of the O-polysaccharide was established: →4)-β-Psep5Ac7Ac-(2 → 3)-β-d-Galp-(1 → 6)-β-d-Galf-(1 → 3)-α-d-Galp-(1→ It differs from a structurally related O-polysaccharide of E...
February 28, 2017: Carbohydrate Research
keyword
keyword
17465
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"