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Lipopolysaccharide

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https://www.readbyqxmd.com/read/29342179/the-polymethoxy-flavonoid-sudachitin-suppresses-inflammatory-bone-destruction-by-directly-inhibiting-osteoclastogenesis-due-to-reduced-ros-production-and-mapk-activation-in-osteoclast-precursors
#1
Yoko Ohyama, Junta Ito, Victor J Kitano, Jun Shimada, Yoshiyuki Hakeda
Inflammatory bone diseases, including rheumatoid arthritis, periodontitis and peri-implantitis, are associated not only with the production of inflammatory cytokines but also with local oxidative status, which is defined by intracellular reactive oxygen species (ROS). Osteoclast differentiation has been reported to be related to increased intracellular ROS levels in osteoclast lineage cells. Sudachitin, which is a polymethoxyflavone derived from Citrus sudachi, possesses antioxidant properties and regulates various functions in mammalian cells...
2018: PloS One
https://www.readbyqxmd.com/read/29341943/beneficial-effect-of-chronic-treatment-with-extracts-from-rhodiola-rosea-l-and-curcuma-longa-l-on-the-immunoreactivity-of-animals-subjected-to-a-chronic-mild-stress-model
#2
Liliya V Vasileva, Kremena Е Saracheva, Mariya V Ivanovska, Atanaska P Petrova, Emir Sucouglu, Mariana A Murdjeva, Damyanka P Getova-Spasova
BACKGROUND: Recent studies have suggested increased levels of pro-inflammatory cytokines in depression. AIM: The present study aimed to evaluate the effect of extracts from Rhodiola and Curcuma on immunoreactivity of animals subjected to a chronic mild stress (CMS) model followed by lipopolysaccharide-induced inflammation. MATERIALS AND METHODS: Male Wistar rats (n=56) divided in 7 groups were treated orally with: distilled water 10 ml/kg (control and CMS model groups); Rhodiola 250 mg/kg; Rhodiola 500 mg/kg; Curcuma 250 mg/kg; Curcuma 500 mg/kg, Rhodiola 250 mg/kg and Curcuma 250 mg/kg...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29341892/premature-aging-in-behavior-and-immune-functions-in-tyrosine-hydroxylase-haploinsufficient-female-mice-a-longitudinal-study
#3
A Garrido, J Cruces, N Ceprián, C Hernández-Sánchez, M De la Fuente
Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. In this context, there is an age-related alteration of the physiological response to acute stress, which is modulated by catecholamine (CA), final products of the sympathetic-adreno-medullary axis. The involvement of CA in essential functions of the nervous system is consistent with the neuropsychological deficits found in mice with haploinsufficiency (hemizygous; HZ) of tyrosine hydroxylase (TH) enzyme (TH-HZ)...
January 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29341443/stachyose-improves-inflammation-through-modulating-gut-microbiota-of-high-fat-diet-streptozotocin-induced-type-2-diabetes-in-rats
#4
Guimei Liu, Jia Bei, Li Liang, Guoyong Yu, Lu Li, Quanhong Li
SCOPE: The present study was undertaken to assess the effects of stachyose (STS) on type 2 diabetes in rats, and changes in the gut microbiota compared to metformin (MET). METHODS AND RESULTS: The type 2 diabetic model was successfully established via a high-fat diet (HFD) / streptozotocin (STZ) in Wistar rats, and STS or MET was administered for 4 weeks. Blood was collected to analyze biochemical parameters, pancreas for mRNA expression of related gene and contents of colon for gut microbiota...
January 16, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29341132/acanthoic-acid-suppresses-lipin1-2-via-tlr4-and-irak4-signalling-pathways-in-etoh-and-lipopolysaccharide-induced-hepatic-lipogenesis
#5
Jian Song, Xin Han, You-Li Yao, Ya-Mei Li, Jing Zhang, Dan-Yang Shao, Li-Shuang Hou, Ying Fan, Shun-Zong Song, Li-Hua Lian, Ji-Xing Nan, Yan-Ling Wu
OBJECTIVES: In alcoholic liver disease, alcohol and lipopolysaccharide (LPS) are major stimulation factors of hepatic lipogenesis. Our objective was to determine the protective mechanism of acanthoic acid (AA) in EtOH- and LPS-induced hepatic lipogenesis. METHODS: HSC-T6 cells were treated with ethanol (200 mm) plus LPS (1 μg/ml) for 1 h, followed by AA (10 or 20 μm) for another 6 h. C57BL/6 mice were pretreated with of AA (20 and 40 mg/kg) or equal volume of saline and then exposed to three doses of ethanol (5 g/kg body weight) within 24 h...
January 17, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29340098/icam-1-regulates-macrophage-polarization-by-suppressing-mcp-1-expression-via-mir-124-upregulation
#6
Wei Gu, Lun Yao, Lexing Li, Jianping Zhang, Aaron T Place, Richard D Minshall, Guoquan Liu
Intercellular adhesion molecule-1 is the adhesion molecule mediating leukocyte firm adhesion to endothelial cells, plays a critical role in subsequent leukocyte transmigration. ICAM-1 is also expressed in other cells including macrophages; however, the role of this adhesion molecule in mediating macrophage functions remains enigmatic. We report that ICAM-1 regulates macrophage polarization by positively modulating miR-124 expression. We found higher expression levels of monocyte chemotactic protein-1 in lungs of mice lacking ICAM-1...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339761/new-virulence-factor-csk29544_02616-as-lpxa-binding-partner-in-cronobacter-sakazakii
#7
Seongok Kim, Hyunjin Yoon, Sangryeol Ryu
Cronobacter sakazakii is an opportunistic pathogen that can cause meningitis and necrotizing enterocolitis in premature infants, but its virulence determinants remain largely unknown. In this study, a transposon-mediated random-mutant library of C. sakazakii was used to identify new virulence factors. Compared to wild-type bacteria, a mutant lacking CSK29544_02616 (referred to as labp) was defective in invasion into intestinal epithelial cells (by at least 1000-fold) and showed less phagocytosis by macrophages (by at least 50-fold)...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339744/human-caspase-4-detects-tetra-acylated-lps-and-cytosolic-francisella-and-functions-differently-from-murine-caspase-11
#8
Brice Lagrange, Sacha Benaoudia, Pierre Wallet, Flora Magnotti, Angelina Provost, Fanny Michal, Amandine Martin, Flaviana Di Lorenzo, Bénédicte F Py, Antonio Molinaro, Thomas Henry
Caspase-4/5 in humans and caspase-11 in mice bind hexa-acylated lipid A, the lipid moeity of lipopolysaccharide (LPS), to induce the activation of non-canonical inflammasome. Pathogens such as Francisella novicida express an under-acylated lipid A and escape caspase-11 recognition in mice. Here, we show that caspase-4 drives inflammasome responses to F. novicida infection in human macrophages. Caspase-4 triggers F. novicida-mediated, gasdermin D-dependent pyroptosis and activates the NLRP3 inflammasome. Inflammasome activation could be recapitulated by transfection of under-acylated LPS from different bacterial species or synthetic tetra-acylated lipid A into cytosol of human macrophage...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29339384/a-novel-inhibitor-of-the-lolcde-abc-transporter-essential-for-lipoprotein-trafficking-in-gram-negative-bacteria
#9
Nicholas N Nickerson, Christine C Jao, Yiming Xu, John Quinn, Elizabeth Skippington, Mary Kate Alexander, Anh Miu, Nicholas Skelton, Jessica V Hankins, Michael S Lopez, Christopher M Koth, Steven Rutherford, Mireille Nishiyama
The outer membrane is an essential structural component of Gram-negative bacteria that is composed of lipoproteins, lipopolysaccharides, phospholipids, and integral β-barrel membrane proteins. A dedicated machinery, called the Lol system, ensures proper trafficking of lipoproteins from the inner to the outer membrane. The LolCDE ABC transporter is the inner membrane component, which is essential for bacterial viability. Here, we report a novel pyrrolopyrimidinedione compound, G0507, which was identified in a phenotypic screen for inhibitors of E...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29339319/treatment-with-the-noradrenaline-re-uptake-inhibitor-atomoxetine-alone-and-in-combination-with-the-%C3%AE-2-adrenoceptor-antagonist-idazoxan-attenuates-loss-of-dopamine-and-associated-motor-deficits-in-the-lps-inflammatory-rat-model-of-parkinson-s-disease
#10
Justin D Yssel, Eoin O'Neill, Yvonne M Nolan, Thomas J Connor, Andrew Harkin
The impact of treatment with the noradrenaline (NA) re-uptake inhibitor atomoxetine and the α2-adrenoceptor (AR) antagonist idazoxan in an animal model of Parkinson's disease (PD) was assessed. Concurrent systemic treatment with atomoxetine and idazoxan, a combination which serves to enhance the extra-synaptic availability of NA, exerts anti-inflammatory and neuroprotective effects following delivery of an inflammatory stimulus, the bacterial endotoxin, lipopolysaccharide (LPS) into the substantia nigra. Lesion-induced deficits in motor function (akinesia, forelimb-use asymmetry) and striatal dopamine (DA) loss were rescued to varying degrees depending on the treatment...
January 12, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29339308/antibiotic-resistance-and-virulence-traits-of-bacterial-pathogens-from-infected-freshwater-fish-labeo-rohita
#11
Dharmaraj Ramesh, Sami Souissi
Bacterial infectious diseases are a main dangerous problem in Aquaculture farming. It causes multiple diseases in fish as well as in human being and it has considerable virulence potential. In this connection, the moot of study focus to discriminate bacterial isolates recovered from naturally diseased Labeo rohita fish and their virulent characteristics. Based on the β-haemolysis factor, four isolates (KADR11, KADR12, KADR13 and KADR14) were selected for further delineation. These bacterial isolates showed high similarity with Providencia rettgeri, Aeromonas sp...
January 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29338785/benefits-of-vce-003-2-a-cannabigerol-quinone-derivative-against-inflammation-driven-neuronal-deterioration-in-experimental-parkinson-s-disease-possible-involvement-of-different-binding-sites-at-the-ppar%C3%AE-receptor
#12
Concepción García, María Gómez-Cañas, Sonia Burgaz, Belén Palomares, Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Sara Campo, Joel Ferrer-Hernández, Carolina Pavicic, Carmen Navarrete, M Luz Bellido, Moisés García-Arencibia, M Ruth Pazos, Eduardo Muñoz, Javier Fernández-Ruiz
BACKGROUND: Neuroprotection with cannabinoids in Parkinson's disease (PD) has been afforded predominantly with antioxidant or anti-inflammatory cannabinoids. In the present study, we investigated the anti-inflammatory and neuroprotective properties of VCE-003.2, a quinone derivative of the non-psychotrophic phytocannabinoid cannabigerol (CBG), which may derive its activity at the peroxisome proliferator-activated receptor-γ (PPARγ). The compound is also an antioxidant. METHODS: We evaluated VCE-003...
January 16, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29338496/repeated-lipopolysaccharide-exposure-modifies-immune-and-sickness-behaviour-response-in-an-animal-model-of-chronic-inflammation
#13
Ksenia Musaelyan, Steven Aldridge, Andrea Du Preez, Martin Egeland, Patricia A Zunszain, Carmine M Pariante, Sandrine Thuret, Cathy Fernandes
Repeated lipopolysaccharide exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic lipopolysaccharide administration of doses previously used in depression research to a new mode of escalating dose injections. Adult male BALB/c mice ( n=8/group) were injected intraperitoneally with either a single 0.83 mg/kg dose, a repeated 0.1 mg/kg lipopolysaccharide dose or a dose which escalated weekly from 0...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29337349/phytochemicals-anti-inflammatory-antiproliferative-and-methylglyoxal-trapping-properties-of-zijuan-tea
#14
Xiong Gao, Chi-Tang Ho, Xiaofei Li, Xiaorong Lin, Yuanyuan Zhang, Zhongzheng Chen, Bin Li
Zijuan tea (Camellia sinensis var. assamica) is a unique anthocyanin-rich tea cultivar in China. Although chemical component analysis of Zijuan tea and extraction technology of anthocyanins was widely documented, its functional properties have not been extensively explored. In this study, the anti-inflammatory, antiproliferative, and methylglyoxal (MGO) trapping activities of water extract (ZWE) and ethyl acetate extract (ZEE) of Zijuan tea were investigated for the 1st time. Results showed that ZWE and ZEE exhibited inhibitory effects on nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 production as well as inducible nitric oxide synthase protein (iNOS) expression in lipopolysaccharide (LPS)-induced RAW 264...
January 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29337327/modulating-inflammation-in-a-cutaneous-chronic-wound-model-by-il-10-released-from-collagen-silica-nanocomposites-via-gene-delivery
#15
Xiaolin Wang, Thibaud Coradin, Christophe Hélary
Cutaneous chronic wounds remain a major clinical challenge which requires the development of novel wound dressings. Previously, we showed that collagen-silica nanocomposites consisting of polyethyleneimine (PEI)-DNA complexes associated with silica nanoparticles (SiNP), collagen hydrogel and 3T3 fibroblasts, can work as a local "cell factory". Indeed, the "in-gel" transfection leads to a sustained production and release of biomolecules. Herein, we further explored the possibility for nanocomposites to deliver interleukin-10 (IL-10), a potent anti-inflammatory cytokine, which favors tissue repair...
January 16, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29337217/peptide-drug-stability-the-anti-inflammatory-drugs-pep19-2-5-and-pep19-4lf-in-cream-formulation
#16
Nicole Kuhlmann, Lena Heinbockel, Wilmar Correa, Thomas Gutsmann, Torsten Goldmann, Uwe Englisch, Klaus Brandenburg
In previous years, we developed anti-infective drugs based on antimicrobial peptides (AMPs), which have been shown to effectively block severe infections and inflammation in vitro as well as in vivo. Besides systemic application, the occurrence of severe local infections necessitates a topical application for example in the case of severe skin and soft tissue infections (SSTI). Recent investigations show that the synthetic anti-lipopolysaccharide peptide (SALP) Pep19-2.5 (Aspidasept® I) and a variant called Pep19-4LF (Aspidasept® II) are able to supress inflammation reactions also in keratinocytes, Langerhans cells, and dendritic cells from the skin...
January 11, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29337216/in-vitro-lung-epithelial-cell-transport-and-anti-interleukin-8-releasing-activity-of-liposomal-ciprofloxacin
#17
Ruba S Darweesh, Masahiro Sakagami
As a promising long-acting inhaled formulation, liposomal ciprofloxacin (Lipo-CPFX) was characterized in the in vitro human lung epithelial Calu-3 cell monolayer system, compared to ciprofloxacin in solution (CPFX). Its modulated absorptive transport and uptake, and sustained inhibitory activity against induced pro-inflammatory interleukin-8 (IL-8) release were examined. The absorptive transport and uptake kinetics for Lipo-CPFX and CPFX were determined at 0.1-50 mg/ml in the Transwell system. The Lipo-CPFX transport was then challenged for mechanistic exploration via cell energy depletion, a reduced temperature, endocytosis and/or lipid fusion inhibition, and addition of excess non-loaded liposomes...
January 11, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29337053/oral-ingestion-of-plasmalogens-can-attenuate-the-lps-induced-memory-loss-and-microglial-activation
#18
Md Shamim Hossain, Ayako Tajima, Satoshi Kotoura, Toshihiko Katafuchi
Plasmalogens (Pls) are the special phospholipids which were reported to be reduced in brain and blood samples of Alzheimer's disease (AD) patients, suggested a possibility that an oral ingestion of Pls may prevent the disease progression. Interestingly, the clinical study showed that the daily oral ingestion of Pls among the mild AD patients improved cognition. However, it is unknown of whether the oral ingestion of Pls inhibits the AD like changes in brain e.g., glial activation and accumulation of amyloid beta (Aβ) proteins...
January 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29336487/mig6-reduces-inflammatory-mediators-production-by-regulating-the-activation-of-egfr-in-lps-induced-endotoxemia
#19
Wenting Chen, Hanhui Zhong, Xiaofei Wang, Qiongni Pang, Jinling Zhuang, Jian Hu, Yeming Chen, Jijie Hu, Jinghua Liu, Jing Tang
Epithelial growth factor receptor (EGFR), a tyrosine kinase receptor, plays a critical role in lipopolysaccharide (LPS) induced endotoxemia. Meanwhile, EGFR signaling is regulated by multiple feedback regulators, including mitogen-inducible gene 6 protein (Mig6). However, as an EGFR regulator, the role of Mig6 in endotoxemia is still remained unknown. Here, we reported for the first time that LPS treatment increased the expression of Mig6 and this effect could be inhibited by EGFR inhibitor, PD168393 or erlotinib...
January 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29336470/tnf-%C3%AE-induces-drp1-mediated-mitochondrial-fragmentation-during-inflammatory-cardiomyocyte-injury
#20
Yue-Liang Shen, Ying-Zhou Shi, Gai-Ge Chen, Lin-Lin Wang, Ming-Zhi Zheng, Hong-Feng Jin, Ying-Ying Chen
Dynamin-related peptide 1 (Drpl)-mediated mitochondrial fission is an important process associated with cardiac dysfunction under different pathological conditions. The aim of the present study was to investigate the expression of Drpl during inflammatory myocardial injury. Sprague‑Dawley rats were treated intraperitoneally with lipopolysaccharides (LPS). Furthermore, cultured H9C2 cardiomyocytes were treated with LPS, interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α). Total and mitochondrial proteins were isolated from the heart tissue of rats and from the H9C2 cardiomyocytes...
January 15, 2018: International Journal of Molecular Medicine
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