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https://www.readbyqxmd.com/read/28749082/impact-of-warm-ischemia-time-on-postoperative-renal-function-after-partial-nephrectomy-for-clinical-t1-renal-cell-carcinoma-a-propensity-score-matched-study
#1
Hakmin Lee, Byung Do Song, Seok-Soo Byun, Sang Eun Lee, Sung Kyu Hong
OBJECTIVES: To preserve renal function, partial nephrectomy (PN) is recommended to patients with small renal masses. However, controversy still exists as to whether prolonged ischemia time adversely affects the incidence of chronic kidney disease (CKD) after PN. We analyzed the effect of prolonged warm ischemia time (WIT) on long-term renal function following PN. MATERIALS AND METHODS: We reviewed data from 1,816 patients who underwent PN for clinical T1 renal tumor...
July 27, 2017: BJU International
https://www.readbyqxmd.com/read/28749068/trifecta-outcomes-of-robot-assisted-partial-nephrectomy-in-solitary-kidney-a-vattikuti-collective-quality-initiative-vcqi-database-analysis
#2
Sohrab Arora, Ronney Abaza, James M Adshead, Rajesh K Ahlawat, Benjamin J Challacombe, Prokar Dasgupta, Giorgio Gandaglia, Daniel A Moon, T B Yuvaraja, Umberto Capitanio, Alessandro Larcher, Francesco Porpiglia, James R Porter, Alexander Mottrie, Mahendra Bhandari, Craig Rogers
OBJECTIVES: To analyze the outcomes of robot-assisted partial nephrectomy (RAPN) in patients with a solitary kidney in a large multi-institutional database. PATIENTS AND METHODS: A total of 2755 patients in the Vattikuti Collective Quality Initiative database underwent RAPN by 22 surgeons at 14 centers in nine 9 countries. Out of these patients, 74 underwent RAPN in solitary kidney between 2007 and 2016. A retrospective analysis of the functional and oncological outcomes was performed...
July 27, 2017: BJU International
https://www.readbyqxmd.com/read/28747700/association-of-pre-operative-estimated-gfr-on-post-operative-pulmonary-complications-in-laparoscopic-surgeries
#3
Akihiro Shimomura, Yoshitsugu Obi, Reza Fazl Alizadeh, Shiri Li, Ninh T Nguyen, Michael J Stamos, Kamyar Kalantar-Zadeh, Hirohito Ichii
Despite a large body of evidence showing the pandemic of chronic kidney disease, the impact of pre-operative kidney function on the risk of post-operative pulmonary complications (PPCs) is not well known. We used multivariable logistic regression analyses with 3-level hierarchical adjustments to identify the association of pre-operative estimated glomerular filtration rate (eGFR) with PPCs in laparoscopic surgeries. Among 452,213 patients between 2005 and 2013 in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) Database, a total of 3,727 patients (0...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747358/urinary-renin-angiotensin-markers-in-polycystic-kidney-disease
#4
Mahdi Salih, Dominique M Bovee, Lodi C W Roksnoer, Niek F Casteleijn, Stephan J L Bakker, Ronald T Gansevoort, Robert Zietse, A H Jan Danser, Ewout J Hoorn
In autosomal dominant polycystic kidney disease (ADPKD) activation of the renin-angiotensin aldosterone system (RAAS) may contribute to hypertension and disease progression. Although previous studies focused on circulating RAAS-components, preliminary evidence suggests APDKD may increase urinary RAAS-components. Therefore, our aim was to analyze circulating and urinary RAAS-components in ADPKD. We cross-sectionally compared 60 patients with ADPKD to 57 patients with non-ADPKD chronic kidney disease (CKD). The two groups were matched by gender, estimated glomerular filtration rate (eGFR), blood pressure, and RAAS-inhibitor use...
July 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28746204/direct-acting-antiviral-agent-efficacy-and-safety-in-renal-transplant-recipients-with-chronic-hepatitis-c-virus-infection-a-prisma-compliant-study
#5
Keliang Chen, Pei Lu, Rijin Song, Jiexiu Zhang, Rongzhen Tao, Zijie Wang, Wei Zhang, Min Gu
BACKGROUND: The efficacy and safety of direct-acting antivirals (DAAs) for treating hepatitis C virus (HCV)-infected renal transplant recipients (RTRs) has not been determined. METHODS: We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials and assessed the quality of eligible studies using the Joanna Briggs Institute scale. DAA efficacy and safety were assessed using standard mean difference (SMD) with 95% confidence intervals (95%CIs)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746184/theoretical-mechanism-of-temporary-renal-function-improvement-after-abdominal-aortic-aneurysm-surgery-applications-for-clinical-imaging-and-laboratory-data
#6
Katsuyuki Hoshina, Takafumi Akai, Marie Ohshima, Toshiaki Watanabe, Sota Yamamoto
We evaluated the effects of changes in blood flow due to abdominal aortic aneurysm (AAA) surgery by using a simple zero-dimension model and applied theoretical values to clinical data.The zero-dimension electronic circuit model and diagram of blood flow distribution were created by setting the resistance of the aorta, bilateral iliac arteries, renal arteries, and aneurysm. Resistance of the aneurysm and resistance of the aorta before surgery were compared with that of the aorta after surgery. We set the radius length of each anatomical parameter to calculate theoretical values...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745689/-kidney-injury-molecules-kim-1-mcp-1-and-type-iv-collagen-in-the-assessment-of-activity-of-antineutrophil-cytoplasmic-antibody-associated-glomerulonephritis
#7
N M Bulanov, A G Serova, E I Kuznetsova, M L Bulanova, P I Novikov, L V Kozlovskaya, S V Moiseev
AIM: To assess the significance of determining the serum and urinary concentrations of monocyte chemotactic protein-1 (MCP-1), kidney injury molecule-1 (KIM-1), and type IV collagen in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to estimate the activity of renal involvement in AAV. SUBJECTS AND METHODS: 78 patients (32 men and 46 women) (median age 55 (45; 61) years) with AAV were examined. The patients were divided into 3 groups according to the AAV activity estimated using the Birmingham vasculitis activity Score (BVAS): 1) 25 patients with active ANCA-associated glomerulonephritis (GN); 2) 26 patients with active AAV without renal involvement; 3) 27 patients in sustained AAV remission...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28745686/-effects-of-keto-amino-acids-and-a-low-protein-diet-on-the-nutritional-status-of-patients-with-stages-3b-4-chronic-kidney-disease
#8
S Yu Milovanova, Yu S Milovanov, M V Taranova, I A Dobrosmyslov
AIM: To evaluate the efficacy of keto/amino acids in maintaining protein balance and preventing mineral metabolic disturbances and the development of uremic hyperparathyroidism in the long-term use of a low-protein diet (LPD) in patients with Stages 3B-4 chronic kidney disease (CKD). SUBJECTS AND METHODS: Ninety patients with CKD caused by chronic latent glomerulonephritis in 65 patients and chronic tubulointerstitial nephritis of various etiologies (gout, drug-induced, and infection) in 25 were examined...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28745685/-membranous-nephropathy-in-a-russian-population
#9
V A Dobronravov, D A Mayer, O V Berezhnaya, S V Lapin, A V Mazing, V G Sipovsky, A V Smirnov
AIM: To analyze the clinical and morphological manifestations of membranous nephropathy (MN) and to evaluate the efficiency of its therapy. MATERIAL AND METHODS: MN cases in 2009 to 2016 were retrospectively detected with a subsequent analysis of patients with primary MN (PMN). The titer of IgG-autoantibodies to phospholipase A2 receptor (anti-PLA2R Ab) was determined by an indirect immunofluorescence assay. Treatment outcomes, such as the time course of changes in proteinuria, nephrotic syndrome (NS), and the development of complete and partial remissions (CR and PR), were assessed...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28743190/effect-of-obstructive-sleep-apnea-treatment-on-renal-function-in-patients-with-cardiovascular-disease
#10
Kelly A Loffler, Emma Heeley, Ruth Freed, Craig S Anderson, Ben Brockway, Alastair Corbett, Catharina L Chang, James A Douglas, Katherine Ferrier, Neil Graham, Garun S Hamilton, Michael Hlavac, Nigel McArdle, John McLachlan, Sutapa Mukherjee, Matthew T Naughton, Francis Thien, Alan Young, Ronald R Grunstein, Lyle J Palmer, Richard J Woodman, Patrick J Hanly, R Doug McEvoy
RATIONALE: Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. OBJECTIVES: To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with co-existing OSA and cardiovascular disease. METHODS: This was a substudy of the international Sleep Apnea and cardioVascular Endpoints (SAVE) trial that randomized 2717 patients with moderate-severe OSA and established coronary or cerebrovascular disease to receive CPAP plus usual care, or usual care alone...
July 25, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28743130/sglt-2-inhibition-a-potential-new-treatment-for-diabetic-kidney-disease
#11
Robert D Toto
Diabetic nephropathy is the leading cause of kidney failure. Treatments with drugs that block the renin-angiotensin system have proven beneficial in slowing kidney disease progression among those with diabetes; their benefit is limited and they do not stop disease progression. Despite multiple clinical trials of various interventions including dual blockade of the renin-angiotensin system over the past 15 years, no new therapies have emerged to slow kidney disease progression in diabetes. SGLT-2 inhibitors are a new class of antiglycemic drugs that have been shown to lower blood glucose by inhibition of the sodium-glucose transporter 2 in the proximal tubule of the kidney...
July 26, 2017: Nephron
https://www.readbyqxmd.com/read/28743129/fibroblast-growth-factor-23-predicts-mortality-and-end-stage-renal-disease-in-a-canadian-asian-population-with-chronic-kidney-disease
#12
Ishwarlal Jialal, Fernando Camacho, Bharat Nathoo, Paul Tam, Roma Pahwa, George G Wu
BACKGROUND: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Biomarkers that predict end-stage renal disease (ESRD) and/or mortality could usher in new therapeutics to halt this onslaught. While fibroblast growth factor (FGF)23 can predict both ESRD and mortality, it has not been studied in North American CKD patients of Asian ethnicity. METHOD: This is a prospective investigation about the role of FGF23 in 998 Canadian patients of Asian descent with CKD defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/m2 and followed up for 3 years...
July 26, 2017: Nephron
https://www.readbyqxmd.com/read/28742684/endovascular-repair-of-abdominal-aortic-aneurysm-in-patients-physically-ineligible-for-open-repair-very-long-term-follow-up-in-the-evar-2-randomized-controlled-trial
#13
Michael J Sweeting, Rajesh Patel, Janet T Powell, Roger M Greenhalgh
OBJECTIVE: The aim of the study was to compare long-term total and aneurysm-related mortality in physically frail patients with abdominal aortic aneurysm (AAA) randomized to either early endovascular aneurysm repair (EVAR) or no-intervention. SUMMARY BACKGROUND DATA: EVAR-2 remains the sole randomized trial to identify whether EVAR reduces mortality in patients physically ineligible for open repair. METHODS: Between September 1999 and August 2004, 404 patients from 33 centers in the United Kingdom aged ≥60 years with AAA >5...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742104/serum-neutrophil-gelatinase-associated-lipocalin-the-estimation-of-hospital-prognosis-in-patients-with-st-elevated-myocardial-infarction
#14
Victoria Karetnikova, Anastasia Osokina, Olga Gruzdeva, Evgenya Uchasova, Michael Zykov, Victoria Kalaeva, Vasiliy Kashtalap, Kristina Shafranskaya, Olga Barbarash
We aimed to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (sNGAL) for predicting in-hospital outcomes in patients with ST-elevated myocardial infarction (STEMI). Patients admitted within 24 hours of developing STEMI clinical symptoms were evaluated for sNGAL on hospitalization days 1 and 12. Recurrent myocardial infarction, early post-infarction angina, acute cerebrovascular accident, and death were assessed as adverse outcomes during hospitalization. The actors associated with adverse outcome were evaluated using univariate and multivariate regression analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28742013/first-canadian-experience-with-donation-after-cardiac-death-simultaneous-pancreas-and-kidney-transplants
#15
Patrick T Anderson, Shahid Aquil, Kelly McLean, Vivian C McAlister, Alp Sener, Patrick P Luke
BACKGROUND: Compared with neurologic determination of death (NDD) donor organs, donation after cardiac death (DCD) donor organs have traditionally been considered of inferior quality owing to warm ischemia experienced during procurement. We present, to our knowledge, the first analysis of simultaneous pancreas and kidney (SPK) transplants using DCD donor organs in Canada. METHODS: We carried out a retrospective cohort study of SPK transplants from 13 DCD and 68 NDD donors performed between October 2008 and July 2016...
August 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28741082/dietary-total-antioxidant-capacity-and-incidence-of-chronic-kidney-disease-in-subjects-with-dysglycemia-tehran-lipid-and-glucose-study
#16
Golaleh Asghari, Emad Yuzbashian, Sahar Shahemi, Zahra Gaeini, Parvin Mirmiran, Fereidoun Azizi
PURPOSE: We aimed to investigate the association of dietary total antioxidant capacity (TAC) with incidence of CKD in subjects with dysglycemia. METHODS: We followed-up 1179 subjects aged ≥30 years with dysglycemia from the Tehran Lipid and Glucose Study (TLGS) for 3 years, who were initially free of CKD. Dietary intakes of TAC, vitamin C, vitamin E, and β-carotene were assessed by a food-frequency questionnaire at the baseline. Dietary TAC was estimated using the oxygen radical absorbance capacity method...
July 24, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28741051/a-nationwide-prospective-cohort-study-of-patients-with-advanced-chronic-kidney-disease-in-japan-the-reach-j-ckd-cohort-study
#17
Junichi Hoshino, Kei Nagai, Hirayasu Kai, Chie Saito, Yukiko Ito, Koichi Asahi, Masahide Kondo, Kunitoshi Iseki, Chiho Iseki, Hirokazu Okada, Naoki Kashihara, Ichiei Narita, Takashi Wada, Christian Combe, Ronald L Pisoni, Bruce M Robinson, Kunihiro Yamagata
BACKGROUND: Epidemiology and outcomes of Japanese patients with advanced chronic kidney disease (CKD)-an estimated glomerular filtration rate (eGFR) < 45 ml/min/1.73 m(2)-has remained largely unexamined. METHODS: We conducted a nationwide survey to determine the distribution of Japanese CKD patients, and are conducting a cohort study of these patients. A questionnaire eliciting details about facilities and their CKD practices was sent to all clinics/hospitals with nephrologists...
July 24, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28741049/the-assessment-of-renal-cortex-and-parenchymal-volume-using-automated-ct-volumetry-for-predicting-renal-function-after-donor-nephrectomy
#18
Yosuke Mitsui, Takuya Sadahira, Motoo Araki, Koichiro Wada, Ryuta Tanimoto, Yuichi Ariyoshi, Yasuyuki Kobayashi, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu
BACKGROUND: Contrast-enhanced CT is necessary before donor nephrectomy and is usually combined with a Tc-99m-mercapto-acetyltriglycine (MAG3) scan to check split renal function (SRF). However, all transplant programs do not use MAG3 because of its high cost and exposure to radiation. We examined whether CT volumetry of the kidney can be a new tool for evaluating SRF. METHODS: Sixty-three patients underwent live donor nephrectomy. Patients without a 1.0 mm slice CT or follow-up for <12 months were excluded leaving 34 patients' data being analyzed...
July 24, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28740370/kidney-function-and-cognitive-decline-in-an-oldest-old-chinese-population
#19
Kunhao Bai, Yujing Pan, Fanghong Lu, Yingxin Zhao, Jinwei Wang, Luxia Zhang
BACKGROUND: Early-stage chronic kidney disease has been suggested to be correlated with cognitive decline, but the association has rarely been explored in the oldest old. SUBJECTS AND METHODS: This prospective study included 284 Chinese participants aged 80 years or older with serum creatinine levels <150 µmol/L. The median follow-up time was 3.3 years, and 247 (87.0%) participants provided valid data at their last visit. Kidney function was evaluated by measuring the estimated glomerular filtration rate (eGFR) at baseline, and cognitive function was evaluated using the Mini-Mental State Examination (MMSE) at both baseline and annual visits...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28740259/proteinuria-detected-by-urine-dipstick-test-as-a-risk-factor-for-atrial-fibrillation-a-nationwide-population-based-study
#20
Woo-Hyun Lim, Eue-Keun Choi, Kyung-Do Han, Tae-Min Rhee, Hyun-Jung Lee, So-Ryoung Lee, Si-Hyuck Kang, Myung-Jin Cha, Seil Oh
Proteinuria is one of the well-known risk factors for cardiovascular disease. However the impact of proteinuria on the incidence of atrial fibrillation (AF) is unclear. In this study, we investigated the association between proteinuria detected using urine dipstick test and the risk of AF. A total of 18,201,275 individuals were analyzed, who had no prior AF and had received biennial health checkups provided by the National Health Insurance Service between 2005 and 2008 in Korea. Incidences of AF were ascertained through the end of 2015...
July 24, 2017: Scientific Reports
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