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estimated glomerular filtration rate

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https://www.readbyqxmd.com/read/29791905/disparities-in-chronic-kidney-disease-prevalence-among-males-and-females-in-195-countries-analysis-of-the-global-burden-of-disease-2016-study
#1
Boris Bikbov, Norberto Perico, Giuseppe Remuzzi
BACKGROUND: Chronic kidney disease (CKD) imposes a substantial burden on health care systems. There are some especially vulnerable groups with a high CKD burden, one of which is women. We performed an analysis of gender disparities in the prevalence of all CKD stages and renal replacement therapy (defined as impaired kidney function [IKF]) in 195 countries. METHODS: We used estimates produced by the Global Burden of Disease (GBD) Study 2016 revision using a Bayesian-regression analytic tool, DisMoD-MR 2...
May 23, 2018: Nephron
https://www.readbyqxmd.com/read/29790109/value-of-three-dimensional-speckle-tracking-echocardiography-to-assess-left-ventricular-function-in-hyperuricemia-patients
#2
Xiaojie Zhang, Qing Lu, Zhuojun Zhang, Yongle Chen, Yanan Wang, Youngshi Wang, Zheng Li, Lindi Jiang
To assess the value of three-dimensional speckle tracking echocardiography (3D STE) in evaluating the left ventricular (LV) function in hyperuricemia patients. We enrolled 15 healthy controls and 40 hyperuricemia patients and collected and analyzed full-volume 3D STE images of the left ventricle in the apical four-chamber heart view. Laboratory tests and 3D STE parameters, including left ventricular ejection fraction, left ventricular end-diastolic volume, left ventricular end-systolic volume, stroke volume (SV), global longitudinal strain (GLS), and global circumferential strain (GCS), were compared between hyperuricemia patients and healthy controls...
May 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29789986/optimal-equation-for-estimation-of-glomerular-filtration-rate-in-autosomal-dominant-polycystic-kidney-disease-influence-of-tolvaptan
#3
Tsuyoshi Yamaguchi, Eiji Higashihara, Takatsugu Okegawa, Isao Miyazaki, Kikuo Nutahara
BACKGROUND: The reliability of various equations for estimating the GFR in ADPKD patients and the influence of tolvaptan on the resulting estimates have not been examined when GFR is calculated on the basis of inulin clearance. METHODS: We obtained baseline and on-tolvaptan measured GFRs (mGFRs), calculated on the basis of inulin clearance, in 114 ADPKD, and these mGFRs were compared with eGFRs calculated according to four basic equations: the MDRD, CKD-EPI, and JSN-CKDI equations and the Cockcroft-Gault formula, as well as the influence of tolvaptan and of inclusion of cystatin C on accuracy of the results...
May 22, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29788704/low-estimated-glomerular-filtration-rate-is-prevalent-among-north-korean-refugees-in-south-korea
#4
Young-Soo Song, Seong-Woo Choi
BACKGROUND: The number of North Korean refugees entering South Korea is rising. Few studies have investigated the risk of non-communicable disease in North Korean refugees. Moreover, kidney insufficiency, a risk factor for cardiovascular disease, has not been studied in this population. We compared the prevalence of non-communicable disease and kidney function in North Korean refugees and South Koreans. METHODS: Our study was conducted using a case-control design...
May 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29788462/clinicopathological-predictors-for-progression-of-chronic-kidney-disease-in-nephrosclerosis-a-biopsy-based-cohort-study
#5
Masayuki Yamanouchi, Junichi Hoshino, Yoshifumi Ubara, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Koki Mise, Tadashi Toyama, Akinori Hara, Miho Shimizu, Kengo Furuichi, Takashi Wada
Background: Biopsy-based studies on nephrosclerosis are lacking and the clinicopathological predictors for progression of chronic kidney disease (CKD) are not well established. Methods: We retrospectively assessed 401 patients with biopsy-proven nephrosclerosis in Japan. Progression of CKD was defined as new-onset end-stage renal disease, decrease of estimated glomerular filtration rate (eGFR) by  ≥50% or doubling of serum creatinine, and the sub-distribution hazard ratio (SHR) with 95% confidence interval (CI) for CKD progression was determined for various clinical and histological characteristics in competing risks analysis...
May 19, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29786454/serum-cystatin-c-as-an-early-predictor-of-acute-kidney-injury-in-preterm-neonates-with-respiratory-distress-syndrome
#6
Tarek Mohey El-Gammacy, Dina Mohamed Shinkar, Noha Refaat Mohamed, Amany Rasmy Al-Halag
Preterm neonates with respiratory distress syndrome (RDS) are at increased risk of acute kidney injury (AKI). Our study aimed at determining whether serum cystatin C (sCysC) on day 3 of life (D3) can early predict AKI in preterm neonates with RDS. This prospective study was conducted on 75 preterm neonates; 50 with RDS and 25 without RDS. On D3, sCysC, serum creatinine (sCr) and blood urea nitrogen (BUN) were measured and estimated glomerular filtration rate (eGFR) was calculated. sCr and BUN levels were measured again on days 5 and 7...
May 22, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29785274/cross-sectional-assessment-of-achievement-of-therapeutic-goals-in-a-canadian-multidisciplinary-clinic-for-patients-with-advanced-chronic-kidney-disease
#7
Félix Rinfret, France Lambert, Joseph Tchetagni Youmbissi, Jean-François Arcand, Richard Turcot, Maral Alimardani Bessette, Solange Bourque, Vincent Moreau, Karine Tousignant, Diane Deschênes, Lyne Cloutier
Background: The implementation of advanced chronic kidney disease (CKD) multidisciplinary clinics has now demonstrated their effectiveness in delaying and even avoiding dialysis for patients with CKD. However, very little has been documented on the management and achievement of targets for a number of parameters in this context. Objective: Our goal was to assess our multidisciplinary clinic therapy performance in relation to the targets for hypertension, anemia, and calcium phosphate assessment...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29784615/autosomal-dominant-tubulointerstitial-kidney-disease-clinical-presentation-of-patients-with-adtkd-umod-and-adtkd-muc1
#8
Nadia Ayasreh, Gemma Bullich, Rosa Miquel, Mónica Furlano, Patricia Ruiz, Laura Lorente, Oliver Valero, Miguel Angel García-González, Nisrine Arhda, Intza Garin, Víctor Martínez, Vanessa Pérez-Gómez, Xavier Fulladosa, David Arroyo, Alberto Martínez-Vea, Mario Espinosa, Jose Ballarín, Elisabet Ars, Roser Torra
RATIONALE & OBJECTIVE: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare underdiagnosed cause of end-stage renal disease (ESRD). ADTKD is caused by mutations in at least 4 different genes: MUC1, UMOD, HNF1B, and REN. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: 56 families (131 affected individuals) with ADTKD referred from different Spanish hospitals. Clinical, laboratory, radiologic, and pathologic data were collected, and genetic testing for UMOD, MUC1, REN, and HNF1B was performed...
May 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29784612/risk-of-progression-of-nonalbuminuric-ckd-to-end-stage-kidney-disease-in-people-with-diabetes-the-cric-chronic-renal-insufficiency-cohort-study
#9
Digsu N Koye, Dianna J Magliano, Christopher M Reid, Christopher Jepson, Harold I Feldman, William H Herman, Jonathan E Shaw
BACKGROUND: Reduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the frequency with which it progresses to end-stage kidney disease (ESKD) is unknown. STUDY DESIGN: Multicenter prospective cohort study. SETTING & PARTICIPANTS: We included 1,908 participants with diabetes and reduced GFR enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study in the United States...
May 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29783932/the-association-of-angiogenic-factors-and-chronic-kidney-disease
#10
Christopher E Anderson, L Lee Hamm, Gem Batuman, Damodar R Kumbala, Chung-Shiuan Chen, Swapna G Kallu, Ravi Siriki, Shilpa Gadde, Myra A Kleinpeter, N Kevin Krane, Eric E Simon, Jiang He, Jing Chen
BACKGROUND: There are limited data on the associations of circulating angiogenic factors with chronic kidney disease (CKD). We investigate the associations of circulating vascular endothelial growth factor (VEGF)-A, angiopoietin-1, angiopoietin-1/VEGF-A ratio, VEGF receptor 1 (VEGFR-1), VEGFR-2, and pentraxin-3 with CKD. METHODS: We recruited 201 patients with CKD and 201 community controls without CKD from the greater New Orleans area. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1...
May 21, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29783931/short-term-sequelae-of-preeclampsia-a-single-center-cohort-study
#11
Michael Girsberger, Catherine Muff, Irene Hösli, Michael Jan Dickenmann
BACKGROUND: Data on the prevalence of persistent symptoms in the first year after preeclampsia are limited. Furthermore, possible risk factors for these sequelae are poorly defined. We investigated kidney function, blood pressure, proteinuria and urine sediment in women with preeclampsia 6 months after delivery with secondary analysis for possible associated clinical characteristics. METHODS: From January 2007 to July 2014 all women with preeclampsia and 6-months follow up at the University Hospital Basel were analyzed...
May 21, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29783062/ykl-40-levels-increase-with-declining-ankle-brachial-index-and-are-associated-with-long-term-cardiovascular-mortality-in-peripheral-arterial-disease-patients
#12
Clemens Höbaus, Maximilian Tscharre, Carsten Thilo Herz, Gerfried Pesau, Thomas Wrba, Renate Koppensteiner, Gerit-Holger Schernthaner
BACKGROUND AND AIMS: YKL-40 is an inflammatory marker secreted by macrophages and is expressed in atherosclerotic plaques. YKL-40 increases in coronary artery disease (CAD) with poor coronary collateral vessel development. Higher levels are linked to reduced survival in CAD patients. Studies evaluating YKL-40 in patients with peripheral arterial disease (PAD) are scarce. This study aims to elucidate a possible link between YKL-40 and PAD severity as well as cardiovascular long-term mortality...
May 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29782819/analytical-performance-of-an-immunoassay-to-measure-proenkephalin
#13
Leslie J Donato, Jeffrey W Meeusen, John C Lieske, Deborah Bergmann, Andrea Sparwaßer, Allan S Jaffe
BACKGROUND: Endogenous opioids, enkephalins, are known to increase with acute kidney injury. Since the mature pentapeptides are unstable, we evaluated the performance of an assay that measures proenkephalin 119-159 (PENK), a stable peptide formed concomitantly with mature enkephalins. METHODS: PENK assay performance was evaluated on two microtiterplate/chemiluminescence sandwich immunoassay formats that required 18 or 1 h incubation times. PENK concentration was measured in plasma from healthy individuals to establish a reference interval and in patients with varied levels of kidney function and comorbidities to assess the association with measured glomerular filtration rate (mGFR) using iothalamate clearance...
May 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29780646/incorporating-cystatin-c-to-predict-methotrexate-elimination-in-patients-with-cns-lymphoma-and-suspicious-renal-function
#14
Jason N Barreto, Allison L McClanahan, Andrew D Rule, Carrie A Thompson, Erin Frazee
High-dose methotrexate (MTX; ≥1 g/m2 ) is a renally eliminated and nephrotoxic first-line therapy for central nervous system (CNS) lymphoma. Creatinine-based estimation of renal function is the recommended approach to dosing MTX in these cases, but nonrenal determinants of creatinine production and elimination in cancer patients such as malnutrition and cachexia lead to overestimation of glomerular filtration rate (GFR) by this method and a heightened risk for drug toxicity. Serum cystatin C is one of the first readily available, relatively inexpensive, endogenous biomarkers to emerge as a practical adjunct to creatinine for estimation of renal function for drug dosing...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29780416/physiological-aldosterone-concentrations-are-associated-with-alterations-of-lipid-metabolism-observations-from-the-general-population
#15
M Hannich, H Wallaschofski, M Nauck, M Reincke, C Adolf, H Völzke, R Rettig, A Hannemann
Objective: Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations of aldosterone and certain components of the lipid metabolism in the peripheral circulation were suggested, but data from the general population is sparse. We therefore aimed to assess the associations between aldosterone and HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, or non-HDL-C in the general adult population...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29779857/factors-affecting-the-incidence-of-contrast-induced-nephropathy-in-patients-undergoing-computed-tomography
#16
M Heras Benito, M Garrido Blázquez, Y Gómez Sanz, M Bernardez Mardomingo, J Ruiz Cacho, F J Rodríguez Recio, M J Fernández-Reyes Luis
OBJECTIVE: To analyze the incidence of contrast-induced nephropathy in a cohort of patients undergoing computed tomography (CT) with intravenous iodinated contrast material. To evaluate the efficacy of N-acetylcysteine in preventing contrast-induced nephropathy. PATIENTS AND METHODS: This prospective observational study was carried out in the months comprising March 2016 through July 2016. We selected the first five patients scheduled to undergo CT examination each day who agreed to participate and signed the informed consent form...
May 17, 2018: Radiología
https://www.readbyqxmd.com/read/29779118/change-in-kidney-function-after-unilateral-adrenalectomy-in-patients-with-primary-aldosteronism-identification-of-risk-factors-for-decreased-kidney-function
#17
Il Young Kim, In Seong Park, Min Jeong Kim, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Sang Heon Song, Hyun Chul Chung
PURPOSE: Glomerular filtration rate (GFR) has been reported to decrease after unilateral adrenalectomy in patients with primary aldosteronism (PA). The aim of this study was to identify clinical predictors for decreased GFR after adrenalectomy in patients with PA. METHODS: The records of 187 patients (98 patients with PA and 89 with non-PA adrenal disease) who were followed up for at least 6 months after unilateral adrenalectomy were retrospectively analyzed. Estimated GFR (eGFR) was investigated at 1, 3, and 6 months postoperatively...
May 19, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29779033/genome-wide-association-study-of-renal-function-traits-results-from-the-japan-multi-institutional-collaborative-cohort-study
#18
Asahi Hishida, Masahiro Nakatochi, Masato Akiyama, Yoichiro Kamatani, Takeshi Nishiyama, Hidemi Ito, Isao Oze, Yuichiro Nishida, Megumi Hara, Naoyuki Takashima, Tanvir Chowdhury Turin, Miki Watanabe, Sadao Suzuki, Rie Ibusuki, Ippei Shimoshikiryo, Yohko Nakamura, Haruo Mikami, Hiroaki Ikezaki, Norihiro Furusyo, Kiyonori Kuriki, Kaori Endoh, Teruhide Koyama, Daisuke Matsui, Hirokazu Uemura, Kokichi Arisawa, Tae Sasakabe, Rieko Okada, Sayo Kawai, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai
BACKGROUND: Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. METHODS: We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29779032/kidney-disease-in-women-is-associated-with-disadvantaged-childhood-socioeconomic-position
#19
Mark Canney, Siobhan Leahy, Siobhan Scarlett, Rose Anne Kenny, Mark A Little, Conall M O'Seaghdha, Cathal McCrory
BACKGROUND: Socioeconomic position (SEP) is an important determinant of health and it is dynamic across the entire lifespan. We sought to investigate the relationship between life-course SEP and chronic kidney disease (CKD) using 3 conceptual models: critical period, pathway and accumulation. METHODS: Cross-sectional analysis of 4,996 participants from The Irish Longitudinal Study on Ageing, a nationally representative cohort of community-dwelling adults aged ≥50 years...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29779029/low-plasma-hydrogen-sulfide-is-associated-with-impaired-renal-function-and-cardiac-dysfunction
#20
Qing Kuang, Ning Xue, Jing Chen, Ziyan Shen, Xiaomeng Cui, Yi Fang, Xiaoqiang Ding
BACKGROUND: Chronic kidney disease (CKD) has been proposed to associate with decreased hydrogen sulfide (H2S) level. Nevertheless, the role of H2S in the pathogenesis of CKD has not been fully investigated. Our study aimed to investigate the plasma level of endogenous H2S in patients with different stages of CKD, and to identify the role of H2S in the progression of CKD and its relationship with cardiovascular diseases. METHODS: A total of 157 non-dialysis CKD patients were recruited in our study, with 37 age- and sex-matched healthy individuals as control...
May 18, 2018: American Journal of Nephrology
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