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https://www.readbyqxmd.com/read/29667173/efficacy-of-corticosteroids-in-prevention-of-acute-kidney-injury-in-neonates-undergoing-cardiac-surgery-a-randomized-controlled-trial
#1
T Jahnukainen, J Keski-Nisula, J Tainio, H Valkonen, T Pätilä, H Jalanko, P Suominen
BACKGROUND: Heart surgery requiring cardiopulmonary bypass (CPB) causes an inflammatory response which may further induce acute kidney injury (AKI). In the present randomized controlled study we evaluated whether corticosteroids can prevent CPB related AKI in neonates undergoing heart surgery. METHODS: Forty neonates were randomized to receive 2 mg/kg methylprednisolone followed by hydrocortisone infusion 0.2 mg/kg/h perioperatively with tapering doses for 5 days, or placebo administered in a similar fashion...
April 17, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29665969/copeptin-plasma-levels-are-associated-with-decline-of-renal-function-in-patients-with-type-2-diabetes-mellitus
#2
Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel Gómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar
BACKGROUND: Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. OBJECTIVE: Evaluate whether plasma copeptin levels may be used as a biomarker of decline renal function in patients with T2DM. RESEARCH DESIGN AND METHODS: A total of 480 patients with T2DM and different stages of CKD were included...
April 14, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29664049/increased-serum-cystatin-c-in-early-parkinson-s-disease-with-objective-sleep-disturbances
#3
Kang-Ping Xiong, Yong-Ping Dai, Jing Chen, Jin-Min Xu, Yi Wang, Ping Feng, Shou-Jiang You, Chun-Feng Liu
Background: Sleep disturbance is one of the major non-motor symptoms which cause the disability of Parkinson's disease (PD) patients. Cystatin C (CysC) is a more sensitive biomarker than serum creatinine or estimated glomerular filtration rate. Previous studies have reported altered CysC levels in neurodegenerative disorders and sleep disorders. This study aimed to explore the correlations of serum CysC levels and objective sleep disturbances in early PD. Methods: We recruited 106 early PD patients and 146 age- and sex-matched controls...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29662050/does-vitamin-d-affect-chronic-renal-allograft-function-in-pediatric-transplant-patients
#4
Brooke Wile, Elisa Yoo, Ana Catalina Alvarez Elias, Lakshmimathy Subramanian, Kathryn Eager, Ajay Parkesh Sharma, Guido Filler
BACKGROUND Correction of hypovitaminosis D is simple, but it is unclear whether it is associated with an accelerated decline of renal allograft function in pediatric renal transplantation patients. This retrospective single center cohort study aimed at analyzing the effect of vitamin D and covariates on the slope of 1/creatinine after the first year. MATERIAL AND METHODS After ethics committee approval, 37 (14 male) pediatric renal transplant recipients on mycophenolate mofetil, who were followed between 2006 and 2014, were included in this study...
April 17, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29661604/cardiovascular-risk-assessment-in-prediabetic-patients-in-a-hypertensive-population-the-role-of-cystatin-c
#5
Rafael Garcia-Carretero, Luis Vigil-Medina, Inmaculada Mora-Jimenez, Cristina Soguero-Ruiz, Rebeca Goya-Esteban, Javier Ramos-Lopez, Oscar Barquero-Perez
BACKGROUND: The aim of our study was to determine whether prediabetes increases cardiovascular (CV) risk compared to the non-prediabetic patients in our hypertensive population. Once this was achieved, the objective was to identify relevant CV prognostic features among prediabetic individuals. METHODS: We included hypertensive 1652 patients. The primary outcome was a composite of incident CV events: cardiovascular death, stroke, heart failure and myocardial infarction...
April 10, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29659743/association-of-biomarker-and-physiologic-indices-with-mortality-in-older-adults-cardiovascular-health-study
#6
Jason L Sanders, Alice M Arnold, Robert M Boudreau, Calvin H Hirsch, Jorge R Kizer, Robert C Kaplan, Anne R Cappola, Mary Cushman, Mini E Jacob, Stephen B Kritchevsky, Anne B Newman
Background: A goal of gerontology is discovering aging phenotypes that reflect biological aging distinct from disease pathogenesis. Biomarkers strongly and independently associated with mortality and which statistically attenuate chronologic age could be used to define such a phenotype. We determined the association of a Biomarker Index (BI) with mortality and compared it to a validated Physiologic Index (PI) in older adults. Methods: The indices were constructed in the Cardiovascular Health Study, mean (SD) age 74...
April 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29653105/cst3-and-gdf15-ameliorate-renal-fibrosis-by-inhibiting-fibroblast-growth-and-activation
#7
Young-Im Kim, Hyun-Woo Shin, Yang-Sook Chun, Jong-Wan Park
The final strategies to care patients with end-stage renal fibrosis rely on dialysis and kidney transplantation. Because such treatments are invasive and cause health problems eventually, it is necessary to develop new therapeutic strategies for delaying the disease progress. We here searched for cytokines showing an anti-fibrotic activity in cell-based experiments. Cystatin C (CST3) and Growth differentiation factor 15 (GDF15) were identified to have anti-fibrotic activities in a cytokine array screening. In primary fibroblasts isolated from the mouse kidneys subjected to ureteral obstruction-induced fibrosis, each cytokine induced apoptotic cell death and reduced collagen production...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29650557/sputum-proteomics-and-airway-cell-transcripts-of-current-and-ex-smokers-with-severe-asthma-in-u-biopred-an-exploratory-analysis
#8
Kentaro Takahashi, Stelios Pavlidis, Francois Ng Kee Kwong, Uruj Hoda, Christos Rossios, Kai Sun, Matthew Loza, Fred Baribaud, Pascal Chanez, Steve J Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Sven-Eric Dahlen, N Krug, Thomas Sandstrom, Dominic E Shaw, Rene Lutter, Per Bakke, Louise J Fleming, Peter H Howarth, Massimo Caruso, Ana R Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Ratko Djukanovic, Peter J Sterk, Yike Guo, Ian M Adcock, Kian Fan Chung
Background: Severe asthma patients with a significant smoking history have airflow obstruction with reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of smoking and ex-smoking severe asthma molecular phenotypes. Methods: The U-BIOPRED severe asthma patients containing current-smokers (CSA), ex-smokers (ESA), non-smokers (NSA) and healthy non-smokers (NH) was examined. Blood and sputum cell counts, fractional exhaled nitric oxide and spirometry were obtained. Exploratory proteomic analysis of sputum supernatants and transcriptomic analysis of bronchial brushings, biopsies and sputum cells was performed...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29650400/corrigendum-to-serum-cystatin-c-levels-are-associated-with-coronary-artery-calcification-in-women-without-chronic-kidney-disease-j-cardiol-70-2017-559-564
#9
Hiroyasu Sugiyama, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Yuji Koide, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito
No abstract text is available yet for this article.
April 9, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29649795/effect-of-hybrid-blood-purification-treatment-on-secondary-hyperparathyroidism-for-maintenance-hemodialysis-patients
#10
Xiao-Fang Gao, Jian-Dong Li, Li Guo, Shan-Shan Guo, Ran Zhang, Yan-Li Gou, Hang Chen
OBJECTIVE: This study aims to investigate the effects of hybrid blood purification treatment on secondary hyperparathyroidism for maintenance hemodialysis (HD) patients. METHODS: A total of 40 patients were randomly divided into 2 groups: HD combined with hemoperfusion (HD + HP) group (n = 20) and HD group (n = 20). Changes in intact parathyroid hormone (iPTH) in these 2 groups were compared before and after treatment, and iPTH levels in the HD + HP group were monitored before and after treatment...
April 12, 2018: Blood Purification
https://www.readbyqxmd.com/read/29648468/in-healthy-normotensive-subjects-age-and-blood-pressure-better-predict-subclinical-vascular-and-cardiac-organ-damage-than-atherosclerosis-biomarkers
#11
Alessandro Maloberti, Francesca Farina, Marco Carbonaro, Enrico Piccinelli, Ilaria Bassi, Francesco Pansera, Guido Grassi, Giuseppe Mancia, Paola Palestini, Cristina Giannattasio
PURPOSE: Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI-1), P-Selectin, Tissue Inhibitors Metalloproteinases type 1 (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) in normotensive and normoglycemic subjects without known cardiovascular and kidney diseases. MATERIALS AND METHODS: 480 blood donors participated at the present analysis...
April 12, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29644068/the-relationship-between-kidney-function-and-quality-of-life-among-community-dwelling-adults-varies-by-age-and-filtration-marker
#12
Mark Canney, Eithne Sexton, Katy Tobin, Rose Anne Kenny, Mark A Little, Conall M O'Seaghdha
Background: The impact of a diminished level of kidney function on the well-being of an older individual is poorly understood. We sought to determine the association between estimated glomerular filtration rate (eGFR) and overall quality of life (QoL) among older adults. Methods: Cross-sectional analysis of 4293 participants from the Irish Longitudinal Study on Ageing, a population-based study of community-dwelling adults ≥50 years of age. We used multivariable negative binomial regression to model the relationship between categories of cystatin C eGFR (eGFRcys ) or creatinine eGFR (eGFRcr ) and the number of QoL deficits from the Control, Autonomy, Self-realization and Pleasure (CASP-19) scale, a holistic measure of QoL among older adults (range 0-57)...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29643901/evaluation-of-the-effect-of-retrograde-intrarenal-surgery-with-myo-inositol-oxygenase
#13
Cuma Mertoglu, Aliseydi Bozkurt, Ercüment Keskin, Murat Gunay
Objective: To investigate the effect of retrograde intra-renal surgery (RIRS) on kidneys using the myo-inositol oxygenase (MIOX) enzyme. MIOX is a renal tubular-specific novel marker for the early diagnosis of acute kidney injury. Methods: A total of twenty seven individuals that had undergone RIRS to treat kidney stones were included in the study. Biochemical tests were performed on serum samples collected immediately before RIRS (hour 0) and at the 6th and 24th hours after the surgery...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29627485/association-and-prognostic-value-of-serum-cystatin-c-il-18-and-uric-acid-in-urological-patients-with-acute-kidney-injury
#14
Arpan Choudhary, Supriyo Basu, Sujit K Dey, Jayanta K Rout, Ranjit K Das, Ranjan K Dey
PURPOSE: To assess the role of serum Cystatin C, IL-18 and Uric acid in acute kidney injury (AKI) in urological patients, along with their prognostic significance. MATERIALS AND METHODS: Prospective observational study included 61 cases, admitted in urology ward with baseline serum creatinine ≤1.5 mg/dL. All patients had at least one or more predisposing factors for AKI. Daily urine output and creatinine level were checked. Serum levels of biomarkers were measured at baseline and postoperatively after 24 h...
April 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29624112/cathepsin-s-is-associated-with-degradation-of-collagen-i-in-abdominal-aortic-aneurysm
#15
Veronika Klaus, Fadwa Schmies, Christian Reeps, Matthias Trenner, Sarah Geisbüsch, Fabian Lohoefer, Hans-Henning Eckstein, Jaroslav Pelisek
BACKGROUND: Cathepsins have been described in the pathogenesis of abdominal aortic aneurysm (AAA), their exact role, especially in collagen degradation, is still unclear. The aim of the present study was therefore to analyse relevant cathepsins in human AAA tissue samples in relation to collagen I, III, and their degradation products. MATERIALS AND METHODS: Samples from 37 AAA patients obtained from elective open surgical repair and eight healthy non-aneurysmatic aortas from kidney donors were included...
April 6, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29621752/fibroblast-growth-factor-23-a-biomarker-of-kidney-function-decline
#16
David A Drew, Ronit Katz, Stephen Kritchevsky, Joachim H Ix, Michael G Shlipak, Anne B Newman, Andy Hoofnagle, Linda Fried, Mark J Sarnak, Orlando M Gutierrez
BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Previous studies have shown FGF-23 to be a risk factor for incident end-stage renal disease; however, there are less data on the association of FGF-23 with earlier kidney-related outcomes. METHODS: Serum FGF-23 was assayed using an intact ELISA assay in 2,496 participants of the Healthy Aging and Body Composition Study, a cohort of well-functioning older adults...
April 5, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29619879/cisplatin-induced-oxidative-stress-stimulates-renal-fas-ligand-shedding
#17
Hitesh Soni, Damian Kaminski, Rajashekhar Gangaraju, Adebowale Adebiyi
Acute kidney injury (AKI), a significant complication of cisplatin chemotherapy is associated with reactive oxygen species (ROS)-dependent renal cell death, but the cellular targets of ROS in cisplatin nephrotoxicity are not fully resolved. Here, we investigated cisplatin-induced oxidative renal damage and tested the hypothesis that ROS-dependent shedding of death activator Fas ligand (FasL) occurs in cisplatin nephropathy. We show that intraperitoneal injection of sulfobutyl ether-β-cyclodextrin (Captisol™)-solubilized cisplatin elevated the level of lipid peroxidation product malondialdehyde in mouse kidneys and urinary concentration of oxidative DNA damage biomarker 8-hydroxy-2'-deoxyguanosine...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29618167/recombinant-protein-susceptibility-to-proteolysis-in-the-plant-cell-secretory-pathway-is-ph-dependent
#18
Philippe V Jutras, Marie-Claire Goulet, Pierre-Olivier Lavoie, Marc-André D'Aoust, Frank Sainsbury, Dominique Michaud
Cellular engineering approaches have been proposed to mitigate unintended proteolysis in plant protein biofactories, involving the design of protease activity-depleted environments by gene silencing or in situ inactivation with accessory protease inhibitors. Here, we assessed the impact of Influenza virus M2 proton channel on host protease activities and recombinant protein processing in the cell secretory pathway of Nicotiana benthamiana leaves. Transient co-expression assays with M2 and GFP variant pHluorin were first conducted to illustrate the potential of proton export from the Golgi lumen to promote recombinant protein yield...
April 4, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29616409/cardiotoxicity-in-hematological-diseases-are-the-tyrosine-kinase-inhibitors-imatinib-and-nilotinib-safe
#19
Ana Rita G Francisco, Daniela Alves, Cláudio David, Lurdes Guerra, Fausto J Pinto, Ana G Almeida
Chemotherapy-induced cardiotoxicity is a growing concern. The cardiotoxic impact of new drugs such as tyrosine kinase inhibitors is unknown, especially the ones used for chronic myeloid leukemia. We aim to evaluate nilotinib- and imatinib-induced cardiotoxicity. Single-center prospective study of consecutive patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors was conducted during 2015. Patients underwent an initial clinical, laboratorial and echocardiographic evaluation, repeated after 1 year...
April 3, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29615904/canonical-tsh-regulation-of-cathepsin-mediated-thyroglobulin-processing-in-the-thyroid-gland-of-male-mice-requires-taar1-expression
#20
Maria Qatato, Joanna Szumska, Vladislav Skripnik, Eddy Rijntjes, Josef Köhrle, Klaudia Brix
Trace amine-associated receptor 1 (Taar1) has been suggested as putative receptor of thyronamines. These are aminergic messengers with potential metabolic and neurological effects countering their contingent precursors, the thyroid hormones (THs). Recently, we found Taar1 to be localized at the primary cilia of rodent thyroid epithelial cells in vitro and in situ . Thus, Taar1 is present in a location of thyroid follicles where it might be involved in regulation of cathepsin-mediated proteolytic processing of thyroglobulin, and consequently TH synthesis...
2018: Frontiers in Pharmacology
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