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https://www.readbyqxmd.com/read/29913326/serum-cystatin-c-concentration-measured-routinely-is-a-prognostic-marker-for-renal-disease-in-dogs
#1
Naoki Iwasa, Satoshi Takashima, Tatsuo Iwasa, Kazuko Iwasa, Tomomi Suzuki, Yui Kobatake, Hitoshi Kitagawa, Naohito Nishii
This study examined the predictive value of serum cystatin C (Cys-C) concentration, measured during routine periodic health examinations, in the renal prognosis of dogs. A cohort of 140 dogs weighing <15 kg whose serum Cys-C concentrations were measured during periodic health examinations from December 2013 to March 2016 were prospectively studied, with renal disease-related death the predicted end point. Of the 140 dogs, nine died from renal diseases during the follow-up period (539 ± 249 days)...
June 14, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29912597/cystatin-c-as-a-predictor-of-mortality-in-elderly-patients-with-chronic-kidney-disease
#2
Sebastjan Bevc, Nina Hojs, Maša Knehtl, Robert Ekart, Radovan Hojs
BACKGROUND: The prevalence of chronic kidney disease (CKD) in the elderly is high. Serum cystatin C is an accurate marker of kidney function and it also has prognostic utility in CKD patients. The aim of our study was to determine the prediction of serum cystatin C and other markers of kidney function on long-term survival in elderly CKD patients. METHODS: Fifty eight adult Caucasian patients, older than 65 years, without known malignancy, thyroid disease and/or not on steroid therapy were enrolled in the study...
June 18, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29910024/dulaglutide-versus-insulin-glargine-in-patients-with-type-2-diabetes-and-moderate-to-severe-chronic-kidney-disease-award-7-a-multicentre-open-label-randomised-trial
#3
Katherine R Tuttle, Mark C Lakshmanan, Brian Rayner, Robert S Busch, Alan G Zimmermann, D Bradley Woodward, Fady T Botros
BACKGROUND: Many antihyperglycaemic drugs, including insulin, are primarily cleared by the kidneys, restricting treatment options for patients with kidney disease. Dulaglutide is a long-acting glucagon-like peptide-1 receptor agonist that is not cleared by the kidneys, and confers a lower risk of hypoglycaemia than does insulin. We assessed the efficacy and safety of dulaglutide in patients with type 2 diabetes and moderate-to-severe chronic kidney disease. METHODS: AWARD-7 was a multicentre, open-label trial done at 99 sites in nine countries...
June 14, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29907141/serum-and-urine-fgf23-and-igfbp-7-for-the-prediction-of-acute-kidney-injury-in-critically-ill-children
#4
Zhenjiang Bai, Fang Fang, Zhong Xu, Chunjiu Lu, Xueqin Wang, Jiao Chen, Jian Pan, Jian Wang, Yanhong Li
BACKGROUND: Fibroblast growth factor 23 (FGF23) and insulin-like growth factor binding protein 7 (IGFBP-7) are suggested to be biomarkers for predicting acute kidney injury (AKI). We compared them with proposed AKI biomarker of cystatin C (CysC), and aimed (1) to examine whether concentrations of these biomarkers vary with age, body weight, illness severity assessed by pediatric risk of mortality III score, and kidney function assessed by estimated glomerular filtration rate (eGFR), (2) to determine the association between these biomarkers and AKI, and (3) to evaluate whether these biomarkers could serve as early independent predictors of AKI in critically ill children...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29904402/identification-of-csf-biomarkers-by-proteomics-in-guillain-barr%C3%A3-syndrome
#5
Pei Li, Sujie Wang, Ruili Zhang, Jian Pei, Lili Chen, Yibin Cao, Haoliang Zhang, Guofeng Yang
The purpose of the present study was to screen for differentially expressed proteins in the cerebrospinal fluid (CSF) of patients with Guillain-Barré syndrome (GBS). The identification of differentially expressed protein can provide new targets for understanding the pathogenic mechanism, early clinical diagnosis, prognosis and for measuring the effectiveness of interventions. We enrolled 50 GBS patients and 50 meningitis patients (control group) to compare protein expression in CSF. The GBS cases included 28 cases of acute inflammatory demyelinating polyneuropathy (AIDP) and 22 cases of acute motor axonal neuropathy (AMAN)...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29903187/-preparation-of-monoclonal-antibody-against-cystatin-c-and-establishment-of-its-immunoassay-system
#6
Yizhan Yu, Tingting Yang, Pei Liu, Nianchao Wang, Yan Lu, Yahong Huang, Pingping Shen
OBJECTIVE: To prepare human cystatin C( CysC) recombinant protein and produce monoclonal antibodies with high affinity and specificity. Develop a competitive ELISA detection system to detect of CysC in human serum. METHODS: The CysC gene sequence was found on NCBI. The optimized gene fragments were synthesized and the recombinant CysC protein was expressed in Escherichia coli then used to immunize Balb/c mice. The positive hybridoma cell lines were obtained by hybridoma cell fusion techniques and ascites monoclonal antibody was prepared and purified...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902773/a-biophysical-insight-into-the-formation-of-aggregates-upon-trifluoroethanol-induced-structural-and-conformational-changes-in-garlic-cystatin
#7
Mohd Faizan Siddiqui, Bilqees Bano
Intrinsic and extrinsic factors are responsible for the transition of soluble proteins into aggregated form. Trifluoroethanol is among such potent extrinsic factor which facilitates the formation of aggregated structure. It disrupts the interactive forces and destabilizes the native structure of the protein. The present study investigates the effect of trifluoroethanol (TFE) on garlic cystatin. Garlic cystatin was incubated with increasing concentration of TFE (0-90% v/v) for 4 h. Incubation of GPC with TFE induces structural changes thereby resulting in the formation of aggregates...
June 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29898185/standardization-of-a-protocol-for-shotgun-proteomic-analysis-of-saliva
#8
Talita Mendes da Silva Ventura, Nathalia Regina Ribeiro, Aline Salgado Dionizio, Isabela Tomazini Sabino, Marília Afonso Rabelo Buzalaf
INTRODUCTION: Saliva contains numerous proteins and peptides, each of them carries a number of biological functions that are very important in maintaining the oral cavity health and also yields information about both local and systemic diseases. Currently, proteomic analysis is the basis for large-scale identification of these proteins and discovery of new biomarkers for distinct diseases. OBJECTIVE: This study compared methodologies to extract salivary proteins for proteomic analysis...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29896315/novel-concept-to-guide-systolic-heart-failure-medication-by-repeated-biomarker-testing-results-from-time-chf-in-context-of-predictive-preventive-and-personalized-medicine
#9
Nasser Davarzani, Sandra Sanders-van Wijk, Micha T Maeder, Peter Rickenbacher, Evgueni Smirnov, Joël Karel, Thomas Suter, Rudolf A de Boer, Dirk Block, Vinzent Rolny, Christian Zaugg, Matthias E Pfisterer, Ralf Peeters, Hans-Peter Brunner-La Rocca
Background: It is uncertain whether repeated measurements of a multi-target biomarker panel may help to personalize medical heart failure (HF) therapy to improve outcome in chronic HF. Methods: This analysis included 499 patients from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF), aged ≥ 60 years, LVEF ≤ 45%, and NYHA ≥ II, who had repeated clinical visits within 19 months follow-up...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29894673/-prevention-of-periprocedural-kidney-ingury-by-loading-doses-of-statins-in-elective-percutaneous-%C3%B1-oronary-interventions
#10
E O Vershinina, A N Repin, M S Timofeev, V V Udut
PURPOSE OF THE STUDY: To compare the effect of loading doses of atorvastatin and rosuvastatin on the value of the acute kidney injury and acute inflammatory response to elective percutaneous coronary interventions. MATERIALS AND METHODS: An open prospective comparative study included 68 patients referred for elective percutaneous coronary intervention (PCI). At baseline, all patients had been taking statins for a long time as a standard lipid-lowering therapy. The first group included 33 patients who received a loading dose of 80 mg of atorvastatin (As) 12 hours before the intervention with saving this dose for 2-6 days...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29894487/impact-of-chronic-sexual-abuse-and-depression-on-inflammation-and-wound-healing-in-the-female-reproductive-tract-of-hiv-uninfected-and-hiv-infected-women
#11
Mimi Ghosh, Jason Daniels, Maria Pyra, Monika Juzumaite, Mariel Jais, Kerry Murphy, Tonya N Taylor, Seble Kassaye, Lorie Benning, Mardge Cohen, Kathleen Weber
Sexual violence is associated with increased risk of HIV acquisition/transmission in women. Forced sex can result in physical trauma to the reproductive tract as well as severe psychological distress. However, immuno-biological mechanisms linking sexual violence and HIV susceptibility are incompletely understood. Using the Women's Interagency HIV Study repository, a total of 77 women were selected to form 4 groups, stratified by HIV serostatus, in the following categories: 1) no sexual abuse history and low depressive symptom score (below clinically significant cut-off, scores <16) (Control); 2) no sexual abuse history but high depressive symptom score, ≥16 (Depression); 3) chronic sexual abuse exposure and low depressive symptom score (Abuse); 4) chronic sexual abuse exposure and high depressive symptom score (Abuse+Depression)...
2018: PloS One
https://www.readbyqxmd.com/read/29891225/acute-kidney-injury-after-pediatric-cardiac-surgery
#12
REVIEW
Shi-Min Yuan
Acute kidney injury (AKI) is a common complication of pediatric cardiac surgery and is associated with increased morbidity and mortality. Literature of AKI after pediatric cardiac surgery is comprehensively reviewed in terms of incidence, risk factors, biomarkers, treatment and prognosis. The novel RIFLE (pediatric RIFLE for pediatrics), Acute Kidney Injury Network (AKIN) and Kidney Disease Improving Global Outcomes (KDIGO) criteria have brought about unified diagnostic standards and comparable results for AKI after cardiac surgery...
March 30, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29891036/increased-cystatin-c-level-in-st-elevation-myocardial-infarction-predisposes-the-prognosis-of-angioplasty
#13
Guidong Shen, Hongmin Zhu, Hong Ding, Chaoyang Sun, Kun Zhou, Yan Fan, Tao Li, Min Men, Yuewu Chen, Qun Lu, Aiqun Ma
BACKGROUND: The study aimed to evaluate the prognostic value of cystatin C in ST-elevation acute myocardial infarction (STEMI) patients who underwent elective percutaneous coronary intervention (PCI). METHODS: A retrospective study was conducted on 664 STEMI patients from 7 centers who were treated with elective PCI. These patients were divided into 3 groups according their admission cystatin C levels as < 0.84, 0.84-1.03 and ≥1.04mg/L. The all-cause mortalities and the composite endpoints, including mortality, reinfarction, rehospitalization for heart failure and angina or repeat target vessel revascularization were observed for up to 5 years...
June 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29890881/comparative-assessment-on-mechanism-underlying-renal-toxicity-of-commercial-formulation-of-roundup-herbicide-and-glyphosate-alone-in-male-albino-rat
#14
Gabriel A Dedeke, Folarin O Owagboriaye, Kehinde O Ademolu, Olanrewaju O Olujimi, Adeyinka A Aladesida
There have been major concerns that the nephrotoxicity of commercial formulations of Roundup herbicide is due to the active ingredient glyphosate. We therefore investigated and compared the mechanisms underlining the nephrotoxicity of Roundup herbicide and glyphosate alone in rat. Fifty-six adult male rats randomized into 7 groups of 8 rats per group were exposed to Roundup formulation and glyphosate alone daily by gavage at 3.6, 50.4, and 248.4 mg/kg body weight (bw) of glyphosate concentrations for 12 weeks with distilled water administered to the control group...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29890037/impact-of-acute-versus-prolonged-exercise-and-dehydration-on-kidney-function-and-injury
#15
Coen C W G Bongers, Mohammad Alsady, Tom Nijenhuis, Anouk D M Tulp, Thijs M H Eijsvogels, Peter M T Deen, Maria T E Hopman
Exercise and dehydration may be associated with a compromised kidney function and potential signs of kidney injury. However, the kidney responses to exercise of different durations and hypohydration levels are not yet known. Therefore, we aimed to compare the effects of acute versus prolonged exercise and dehydration on estimated glomerular filtration rate (eGFR) and kidney injury biomarkers in healthy male adults. A total of 35 subjects (23 ± 3 years) were included and invited for two study visits. Visit 1 consisted of a maximal cycling test...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29884452/renal-function-and-acute-heart-failure-outcome
#16
REVIEW
Lluís Llauger, Javier Jacob, Òscar Miró
The interaction between acute heart failure (AHF) and renal dysfunction is complex. Several studies have evaluated the prognostic value of this syndrome. The aim of this systematic review, which includes non-selected samples, was to investigate the impact of different renal function variables on the AHF prognosis. The categories included in the studies reviewed included: creatinine, blood urea nitrogen (BUN), the BUN/creatinine quotient, chronic kidney disease, the formula to estimate the glomerular filtration rate, criteria of acute renal injury and new biomarkers of renal damage such as neutrophil gelatinase-associated lipocalin (NGAL and cystatin c)...
June 5, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29884198/acute-kidney-injury-and-mild-therapeutic-hypothermia-in-patients-after-cardiopulmonary-resuscitation-a-post-hoc-analysis-of-a-prospective-observational-trial
#17
Julia Hasslacher, Fabian Barbieri, Ulrich Harler, Hanno Ulmer, Lui G Forni, Romuald Bellmann, Michael Joannidis
BACKGROUND: The aim of this study was to investigate the influence of mild therapeutic hypothermia (MTH) on the incidence of and recovery from acute kidney injury (AKI). METHODS: Patients who had undergone successful cardiopulmonary resuscitation (CPR) were included. Serum creatinine and cystatin C were measured at baseline, daily up to 5 days and at ICU discharge. AKI was defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria. MTH was applied for 24 h targeting a temperature of 33 °C...
June 8, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29883898/identification-of-a-type-ii-cystatin-in-fragaria-chiloensis-a-proteinase-inhibitor-differentially-regulated-during-achene-development-and-in-response-to-biotic-stress-related-stimuli
#18
Uri Aceituno-Valenzuela, María Paz Covarrubias, María Francisca Aguayo, Felipe Valenzuela-Riffo, Analía Espinoza, Carlos Gaete-Eastman, Raúl Herrera, Michael Handford, Lorena Norambuena
The equilibrium between protein synthesis and degradation is key to maintaining efficiency in different physiological processes. The proteinase inhibitor cystatin regulates protease activities in different developmental and physiological contexts. Here we describe for the first time the identification and the biological function of the cysteine protease inhibitor cystatin of Fragaria chiloensis, FchCYS1. Based on primary sequence and 3D-structural homology modelling, FchCYS1 is a type II phytocystatin with high identity to other cystatins of the Fragaria genus...
May 19, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29883558/bapta-am-nanoparticle-for-the-curing-of-acute-kidney-injury-induced-by-ischemia-reperfusion
#19
Zhiyu He, Haoyu Tang, Xinru You, Keqing Huang, Arvind Dhinakar, Yang Kang, Qiaoli Yu, Jun Wu
Ischemia-reperfusion (I/R) is a major cause of acute kidney injury (AKI), which is associated with unacceptably high mortality rates in ICU. This research was designed to explore the therapeutic effect of BAPTA-AM (1,2-Bis(2-aminophenoxy) ethane-N,N,N,N-tetraacetic acid tetrakis(acetoxymethyl ester)) nanoparticle (BA-N) on AKI. BA-N was developed by liposome strategy and characterized by standard methods. The rat model was selected and the rats were randomly allocated into four groups: (1) Normal group; (2) Sham-operated group; (3) Model group (I/R + NS); (4) BA-N treatment group (I/R + BA-N)...
May 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29883532/innovative-use-of-novel-biomarkers-to-improve-the-safety-of-renally-eliminated-and-nephrotoxic-medications
#20
Erin F Barreto, Andrew D Rule, Stacy A Voils, Sandra L Kane-Gill
Over the last decade, the discovery and research into the application of novel renal biomarkers to improve medication efficacy and safety has expanded considerably. Pharmacists are uniquely positioned to leverage this new technology for renal assessment to improve medication dosing and monitoring. Serum cystatin C is a relatively new, inexpensive, functional renal biomarker that responds more quickly to changing renal function than creatinine and is not meaningfully affected by age, sex, skeletal muscle mass, dietary intake, or deconditioning...
June 8, 2018: Pharmacotherapy
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