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https://www.readbyqxmd.com/read/29049808/cold-inducible-ribonucleic-acid-binding-protein-attenuates-acute-kidney-injuries-after-deep-hypothermic-circulatory-arrest-in-rats
#1
Lei Yu, Tianxiang Gu, Yu Liu, Xuan Jiang, Enyi Shi
OBJECTIVES: Cold-inducible ribonucleic acid-binding protein (CIRP) has been identified to play a role in the antiapoptotic effect of hypothermia. We sought to investigate the renoprotection of CIRP in a rat model of deep hypothermic circulatory arrest. METHODS: Overexpression and knockdown of CIRP were achieved in vivo by directly injecting lentivirus vectors containing packaging lentivirus (pL)/internal ribosome entry site (IRES)/green fluorescent protein (GFP)-CIRP or pL/short hairpin RNA (shRNA)/F-cold inducible RNA binding protein (F-CIRP)-A into the renal parenchyma of rats 7 days before deep hypothermic circulatory arrest under the ultrasound guidance...
August 14, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29046353/a-mechanistic-model-to-predict-effects-of-cathepsin-b-and-cystatin-c-on-%C3%AE-amyloid-aggregation-and-degradation
#2
Tyler J Perlenfein, Regina M Murphy
β-Amyloid (Aβ) aggregation is thought to initiate a cascade of neurodegenerative events in Alzheimer's disease (AD). Much effort is underway to develop strategies to reduce Aβ concentration or inhibit aggregation. Cathepsin B (CatB) proteolytically degrades Aβ into nonaggregating fragments, but is potently inhibited by cystatin C (CysC). It has been suggested that decreasing CysC would facilitate Aβ clearance by relieving CatB inhibition. On the other hand, CysC binds Aβ and inhibits Aβ aggregation, suggesting that an intervention that increases CysC would prevent Aβ aggregation...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29045722/subjective-age-and-cystatin-c-among-older-adults
#3
Yannick Stephan, Angelina R Sutin, Antonio Terracciano, Shevaun Neupert
Objective: Cystatin C (CysC) is a marker of kidney function that is relevant for the health and cognition of older adults. Little is known about the link between psychological factors and CysC. Therefore, the present study examined whether subjective age is related to CysC level and changes in CysC over time. Method: Participants were 5,066 individuals drawn from the Health and Retirement Study aged from 50 to 107 years (60% women, mean age = 69.36 years, SD = 9...
October 16, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29042935/decreased-cathepsin-k-levels-in-human-atherosclerotic-plaques-are-associated-with-plaque-instability
#4
Huiying Zhao, Xiujiao Qin, Shuai Wang, Xiwei Sun, Bin Dong
Investigating the determinants and dynamics of atherosclerotic plaque instability is a key area of current cardiovascular research. Extracellular matrix degradation from excessive proteolysis induced by enzymes such as cathepsin K (Cat K) is implicated in the pathogenesis of unstable plaques. The current study assessed the expression of Cat K in human unstable atherosclerotic plaques. Specimens of popliteal arteries with atherosclerotic plaques were classified as stable (<40% lipid core plaque area; n=6) or unstable (≥40% lipid core plaque area; n=14) based on histopathological examinations of hematoxylin and eosin stained sections...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042392/renal-and-cardiovascular-effects-of-sodium-glucose-cotransporter-2-sglt2-inhibition-in-combination-with-loop-diuretics-in-diabetic-patients-with-chronic-heart-failure-recede-chf-protocol-for-a-randomised-controlled-double-blind-cross-over-trial
#5
Natalie A Mordi, Ify R Mordi, Jagdeep S Singh, Fatima Baig, Anna-Maria Choy, Rory J McCrimmon, Allan D Struthers, Chim C Lang
INTRODUCTION: Type 2 diabetes (T2D) and heart failure (HF) are a frequent combination, where treatment options remain limited. There has been increasing interest around the sodium-glucose cotransporter 2 (SGLT2) inhibitors and their use in patients with HF. Data on the effect of SGLT2 inhibitor use with diuretics are limited. We hypothesise that SGLT2 inhibition may augment the effects of loop diuretics and the benefits of SGLT2 inhibitors may extend beyond those of their metabolic (glycaemic parameters and weight loss) and haemodynamic parameters...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29040701/comparison-of-glomerular-filtration-rate-estimating-equations-derived-from-creatinine-and-cystatin-c-validation-in-the-age-gene-environment-susceptibility-reykjavik-elderly-cohort
#6
Jonas Björk, Anders Grubb, Vilmundur Gudnason, Olafur S Indridason, Andrew S Levey, Runolfur Palsson, Ulf Nyman
Background: Validation studies comparing glomerular filtration rate (GFR) equations based on standardized creatinine and cystatin C assays in the elderly are needed. The Icelandic Age, Gene/Environment Susceptibility-Kidney cohort was used to compare two pairs of recently developed GFR equations, the revised Lund-Malmö creatinine equation (LMRCr) and the arithmetic mean of the LMRCr and Caucasian, Asian, Paediatric and Adult cystatin C equations (MEANLMR+CAPA), as well as the Full Age Spectrum creatinine equation (FASCr) and its combination with cystatin C (FASCr+Cys), with the corresponding pair of Chronic Kidney Disease Epidemiology Collaboration equations (CKD-EPICr and CKD-EPICr+Cys)...
October 5, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29038837/reduced-kidney-function-is-associated-with-bmd-bone-loss-and-markers-of-mineral-homeostasis-in-older-women-a-10-year-longitudinal-study
#7
L Malmgren, F McGuigan, A Christensson, K E Akesson
Kidney function decreases with age; however, the long-term influence on bone density (BMD) in older women already at risk of osteoporosis is unknown. We followed kidney function and bone loss for 10 years. Declining kidney function was adversely associated with bone loss and mineral homeostasis in old women, though it attenuated with advanced aging. INTRODUCTION: Existing studies do not fully address the relationship between kidney function and bone metabolism with advanced aging in Caucasian women...
October 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29038354/association-of-urinary-citrate-excretion-ph-and-net-gastrointestinal-alkali-absorption-with-diet-diuretic-use-and-blood-glucose-concentration
#8
Majuran Perinpam, Erin B Ware, Jennifer A Smith, Stephen T Turner, Sharon L R Kardia, John C Lieske
Urinary citrate (Ucit) protects against urinary stone formation. Acid base status and diet influence Ucit. However, the effect of demographics, diet, and glucose metabolism on Ucit excretion, urinary pH (U-pH) and net gastrointestinal alkali absorption (NAA) are not known. Twenty-four hour urine samples, blood glucose, creatinine, and cystatin C were obtained from non-Hispanic white sibships in Rochester, MN (n = 446; 64.5 ± 9 years; 58% female). Diet was assessed by a food frequency questionnaire. The impact of blood glucose, demographics and dietary elements on Ucit excretion, U-pH, and NAA were evaluated in bivariate and multivariable models and interaction models that included age, sex, and weight...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29037838/expression-and-epigenetic-regulation-of-cystatin-b-in-lung-cancer-and-colorectal-cancer
#9
Yunxia Ma, Yuan Chen, Iver Petersen
AIMS: Dysregulated expression of cystatin B (CSTB) has been implicated in various cancers. The aims of this study were to analyze the CSTB expression and investigate the epigenetic regulation of CSTB in lung and colon cancer cell lines, and also evaluate the clinical outcome of CSTB in primary lung and colorectal tumors. METHODS: CSTB expression in lung and colon cancer cell lines was analyzed by real-time RT-PCR and western blotting. Epigenetic regulation of CSTB was examined by demethylation, deacetylation tests and bisulfite sequencing (BS)...
June 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29036887/reference-intervals-for-non-fasting-cvd-lipids-and-inflammation-markers-in-pregnant-indigenous-australian-women
#10
Tracy L Schumacher, Christopher Oldmeadow, Don Clausen, Loretta Weatherall, Lyniece Keogh, Kirsty G Pringle, Kym M Rae
Indigenous Australians experience high rates of cardiovascular disease (CVD). The origins of CVD may commence during pregnancy, yet few serum reference values for CVD biomarkers exist specific to the pregnancy period. The Gomeroi gaaynggal research project is a program that undertakes research and provides some health services to pregnant Indigenous women. Three hundred and ninety-nine non-fasting samples provided by the study participants (206 pregnancies and 175 women) have been used to construct reference intervals for CVD biomarkers during this critical time...
October 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29036269/longitudinal-blood-pressure-changes-and-kidney-function-decline-in-persons-without-chronic-kidney-disease-findings-from-the-mesa-study
#11
Gregory L Judson, Anna D Rubinsky, Michael G Shlipak, Ronit Katz, Holly Kramer, David R Jacobs, Michelle C Odden, Carmen A Peralta
Background: While changes in blood pressure (BP) are independently associated with cardiovascular events, less is known about the association between changes in BP and subsequent changes in renal function in adults with an estimated glomerular filtration rate (eGFR) of > 60 ml/min/1.73 m2. Methods: The present study included 3,920 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) study who had ≥2 BP measurements during the first 5 years of MESA and had eGFR measurements at both year 5 and 10...
October 5, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29029879/reduced-renal-function-in-patients-with-myotonic-dystrophy-type-1-and-the-association-to-ctg-expansion-and-other-potential-risk-factors-for-chronic-kidney-disease
#12
Annika Aldenbratt, Christopher Lindberg, Maria K Svensson
Myotonic dystrophy type 1 (DM1) affects several organs. Disease severity and age at onset are correlated to the CTG repeat expansion. The aim of this study was to assess renal function and the association to numbers of CTG repeat expansion in patients with DM1. Ninety-eight patients with DM1 were included. Glomerular filtration rate (measured GFR) was measured using iohexol clearance. Data on CTG repeats were available in 83/98 (85%) patients. The overall mGFR was 74 (16) ml/min/1.73 m(2) (range 38-134). Sixty-four patients (69%) had a mild and sixteen patients (17%) a moderate decrease in renal function (mGFR 60-89 and 30-59 ml/min/1...
August 15, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29028155/a-parallel-reaction-monitoring-mass-spectrometric-method-for-analysis-of-potential-csf-biomarkers-for-alzheimer-s-disease
#13
Gunnar Brinkmalm, Simon Sjödin, Anja Hviid Simonsen, Steen Gregers Hasselbalch, Henrik Zetterberg, Ann Brinkmalm, Kaj Blennow
PURPOSE: The aim of this study was to develop and evaluate a parallel reaction monitoring mass spectrometry (PRM-MS) assay consisting of a panel of potential protein biomarkers in cerebrospinal fluid (CSF). EXPERIMENTAL DESIGN: Thirteen proteins were selected based on their association with neurodegenerative diseases and involvement in synaptic function, secretory vesicle function, or innate immune system. CSF samples were digested and 2-3 peptides per protein were quantified using stable isotope-labeled peptide standards...
October 13, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29026688/establishing-the-presence-or-absence-of-chronic-kidney-disease-uses-and-limitations-of-formulas-estimating-the-glomerular-filtration-rate
#14
REVIEW
Ahmed Alaini, Deepak Malhotra, Helbert Rondon-Berrios, Christos P Argyropoulos, Zeid J Khitan, Dominic S C Raj, Mark Rohrscheib, Joseph I Shapiro, Antonios H Tzamaloukas
The development of formulas estimating glomerular filtration rate (eGFR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease (CKD), which is based on eGFR values and albuminuria. This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course...
September 26, 2017: World Journal of Methodology
https://www.readbyqxmd.com/read/29025836/assessment-of-potential-predictors-of-calretinin-and-mesothelin-to-improve-the-diagnostic-performance-to-detect-malignant-mesothelioma-results-from-a-population-based-cohort-study
#15
Swaantje Casjens, Daniel G Weber, Georg Johnen, Irina Raiko, Dirk Taeger, Carmen Meinig, Susanne Moebus, Karl-Heinz Jöckel, Thomas Brüning, Beate Pesch
OBJECTIVES: Mesothelin and calretinin are blood-based markers for malignant mesothelioma. The objective of this study was to analyse the markers in plasma samples from cancer-free men and to identify factors influencing their concentrations to minimise false-positive test results when using these markers for the early detection of malignant mesothelioma. SETTING: The present analyses used data and archived blood samples of the population-based Heinz Nixdorf Recall Study among elderly people collected from 2011 to 2014...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29024496/higher-levels-of-cystatin-c-in-hiv-aids-patients-with-metabolic-syndrome
#16
Gordana Dragović, Danica Srdić, Khawla Al Musalhi, Ivan Soldatović, Jovana Kušić, Djordje Jevtović, Devaki Nair
Data about Cystatin-C levels in HIV-infected patients with metabolic syndrome (MetS) are still limited. Therefore, the aim of this study was to evaluate the possible correlations of serum levels of Cystatin-C in HIV/AIDS patients treated with combined antiretroviral therapy (cART) with or without MetS. This cross-sectional study included 89 HIV/AIDS Caucasian patients receiving cART at the HIV/AIDS Centre Belgrade, Serbia, divided into two groups according to the presence of MetS. Cystatin-C and other biochemical parameters were measured using Cytokine-Array-I, Metabolic-Array-I and Metabolic-Array-II, at the Department of Clinical Biochemistry, Royal Free Hospital and University College London, United Kingdom...
October 11, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29022685/inverse-relationship-between-adherence-to-the-mediterranean-diet-and-serum-cystatin-c-levels
#17
Natalia G Vallianou, Ekavi Georgousopoulou, Angelos A Evangelopoulos, Vassiliki Bountziouka, Maria S Bonou, Evangelos D Vogiatzakis, Petros C Avgerinos, John Barbetseas, Demosthenes B Panagiotakos
OBJECTIVE: The aim of the present study was to examine serum cystatin C levels in association with the Mediterranean diet in a healthy Greek population. METHODS: Cystatin C together with basic clinical chemistry tests was measured in a total of 490 adults (46±16 years, 40% of males), who underwent an annual health check. Demographic, anthropometric and lifestyle characteristics were recorded, while adherence to the Mediterranean diet was evaluated through the MedDietScore (0-55)...
September 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29022500/biomarkers-of-atrial-fibrillation-in-metabolic-syndrome
#18
Christos Georgakopoulos, Charalambos Vlachopoulos, Georgios Lazaros, Dimitris Tousoulis
Whether the increased atrial fibrillation (AF) risk in metabolic syndrome (MetS) patients is due to the syndrome as a whole or simply the sum of the risks of its individual component parts is still obscure. These two clinical entities share many pathophysiological links and thus distinction between a casual observation and a significant association is difficult. Biomarkers associated with pathogenesis of AF in the context of MetS have the ability to refine future risk prediction. In the present review we identify circulating substances that could be regarded as potential biomarkers for prediction of incident AF, or of cardiovascular events in the setting of AF in patients with MetS...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29019965/molecular-cloning-recombinant-expression-and-antifungal-activity-of-bncpi-a-cystatin-in-ramie-boehmeria-nivea-l
#19
Yongting Yu, Gang Zhang, Zhimin Li, Yi Cheng, Chunsheng Gao, Liangbin Zeng, Jia Chen, Li Yan, Xiangping Sun, Litao Guo, Zhun Yan
Phytocystatins play multiple roles in plant growth, development and resistance to pests and other environmental stresses. A ramie (Boehmeria nivea L.) phytocystatin gene, designated as BnCPI, was isolated from a ramie cDNA library and its full-length cDNA was obtained by rapid amplification of cDNA ends (RACE). The full-length cDNA sequence (691 bp) consisted of a 303 bp open reading frame (ORF) encoding a protein of 100 amino acids with deduced molecular mass of 11.06 kDa and a theoretical isoelectric point (pI) of 6...
October 11, 2017: Genes
https://www.readbyqxmd.com/read/29019242/salivary-cystatins-exploring-new-post-translational-modifications-and-polymorphisms-by-top-down-high-resolution-mass-spectrometry
#20
Barbara Manconi, Barbara Liori, Tiziana Cabras, Federica Vincenzoni, Federica Iavarone, Massimo Castagnola, Irene Messana, Alessandra Olianas
Cystatins are a complex family of cysteine peptidase inhibitors. In the present study, various proteoforms of cystatin A, cystatin B, cystatin S, cystatin SN, and cystatin SA were detected in the acidic soluble fraction of human saliva and characterized by a top-down HPLC-ESI-MS approach. Proteoforms of cystatin D were also detected and characterized by an integrated top-down and bottom-up strategy. The proteoforms derive from coding sequence polymorphisms and post-translational modifications, particularly phosphorylation, N-terminal processing and oxidation...
October 11, 2017: Journal of Proteome Research
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