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https://www.readbyqxmd.com/read/28344695/are-we-adequately-preparing-the-next-generation-of-physicians-to-prescribe-exercise-as-prevention-and-treatment-residents-express-the-desire-for-more-training-in-exercise-prescription
#1
Kara Solmundson, Michael Koehle, Donald McKenzie
BACKGROUND: Physical activity (PA) is a key intervention for chronic disease, yet few physicians provide exercise prescription (EP). EP is an important component in larger strategies of reducing non-communicable disease (NCD). Our objective was to assess Family Medicine Residents (FMR) knowledge, competence, and perspectives of EP to help inform future curriculum development. METHODS: A 49-item cross-sectional survey was administered to 396 University of British Columbia FMR...
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28343188/multimodal-evoked-potentials-in-patients-with-multiple-sclerosis-in-assessment-of-the-course-of-the-disease
#2
Beata Łabuz-Roszak, Magdalena Torbus, Katarzyna Kubicka-Bączyk, Agnieszka Machowska-Majchrzak, Agata Kierber, Katarzyna Borucka, Małgorzata Zellner, Anna Starostak-Tatar, Krystyna Pierzchała
INTRODUCTION: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system with a multifocal damage. THE AIM: The assessment of the MS course by multimodal evoked potentials (EP). MATERIAL AND METHODS: We evaluated 95 patients (63 female, 32 male) with relapsing-remitting MS in the average age of 36.4±10.4. The average disease duration was 4.6±7.4 year. Among them, 48 patients (50.5%) were treated with immunomodulatory drugs...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28342204/the-ep4-antagonist-l-161-982-induces-apoptosis-cell-cycle-arrest-and-inhibits-prostaglandin-e2-induced-proliferation-in-oral-squamous-carcinoma-tca8113-cells
#3
Xiaohui Li, Bo Yang, Guoxu Han, Weizhong Li
BACKGROUND: Recent studies suggest that cyclooxygenase 2 (COX-2) inhibitors may enhance the toxic effects of anticancer drugs on tumor cells, including oral squamous cell carcinoma(OSCC), but its long-term use can cause side effects such as stomach ulcers and myocardial infarction. Our aim was to investigate proliferative effects of a downstream product of COX-2, prostaglandin E2(PGE2), in human oral squamous carcinoma cell line Tca8113 and explore the effects of PGE2 receptors, especially EP4 receptor, on the growth of Tca8113 cells...
March 25, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28341741/endogenous-prostaglandin-e2-amplifies-il-33-production-by-macrophages-through-an-e-prostanoid-ep-2-ep4-cyclic-camp-epac-dependent-pathway
#4
Sachin K Samuchiwal, Barbara Balestrieri, Hannah Raff, Joshua A Boyce
When activated through toll-like receptors (TLRs), macrophages generate interleukin-33 (IL-33), an IL-1 family member that induces innate immune responses through ST2 signaling. Lipopolysaccharide (LPS), a TLR4 ligand, induces macrophages to generate prostaglandin E2 (PGE2) through inducible cyclooxygenase (COX)-2 and microsomal PGE2 synthase-1 (mPGES-1) (1). We demonstrate that IL-33 production by bone marrow derived murine macrophages (bmMFs) requires the generation of endogenous PGE2 and the intrinsic expression of EP2 receptors to amplify NF-κB-dependent LPS-induced IL-33 expression via Exchange Protein Activated by cAMP (EPAC)...
March 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28340932/predicting-first-trimester-pregnancy-outcome-derivation-of-a-multiple-marker-test
#5
Suneeta Senapati, Mary D Sammel, Samantha F Butts, Peter Takacs, Karine Chung, Kurt T Barnhart
OBJECTIVE: To predict first trimester pregnancy outcome using biomarkers in a multicenter cohort. DESIGN: Case-control study. SETTING: Three academic centers. PATIENT(S): Women with pain and bleeding in early pregnancy. INTERVENTION(S): Sera from women who were 5-12 weeks' gestational age with ectopic pregnancy (EP), viable intrauterine pregnancy (IUP), and miscarriage/spontaneous abortion (SAB) was analyzed by ELISA and immunoassay for activin A, inhibin A, P, A Disintegrin And Metalloprotease-12, pregnancy-associated plasma protein A (PAPP-A), pregnancy specific B1-glycoprotein (SP1), placental-like growth factor, vascular endothelial growth factor, glycodelin (Glyc), and hCG...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/28340493/conservative-treatment-with-octreotide-to-provide-early-recovery-of-children-with-esophageal-perforation
#6
Ramazan Karabulut, Zafer Turkyilmaz, Kaan Sonmez, Abdullah Can Basaklar
Background The effectiveness of nonoperative treatment of esophageal perforation (EP) in children with octreotide is highlighted. Methods Records of nine patients (seven boys and two girls with an average age of 5.83 ± 5.35 years) with EP were reviewed. Results EP developed in six patients during dilation of esophageal stenosis (five of six caused by caustic burns). In the other three patients, EP developed after nasogastric placement, after endotracheal intubation, and during endoscopy for foreign body...
March 24, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28337037/the-diagnostic-performance-of-ultrasound-in-the-detection-of-ectopic-pregnancy
#7
Lee Young, Cecilia Barnard, Elisabeth Lewis, Matthew Jones, Jana Furlan, Angela Karatasiou, Martin Necas
BACKGROUND: Accurate diagnosis of ectopic pregnancy is essential in reducing maternal mortality and morbidity. Transvaginal ultrasound (TVUS) is the accepted imaging modality of choice for the diagnosis of ectopic pregnancy (EP). AIMS: To assess the effectiveness of transvaginal ultrasound (TVUS) in the detection of EP in consecutive women presenting for ultrasound to a radiology department with a clinical suspicion of EP. METHODS: Retrospective analysis of 585 women presenting for TVUS over a 2...
March 24, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28332299/the-use-of-on-line-sfe-sfc-ms-ms-to-analyze-disease-biomarkers-in-dried-serum-spots-compared-with-serum-analysis-using-lc-ms-ms
#8
Makoto Suzuki, Shin Nishiumi, Takashi Kobayashi, Arata Sakai, Yosuke Iwata, Takato Uchikata, Yoshihiro Izumi, Takeshi Azuma, Takeshi Bamba, Masaru Yoshida
RATIONALE: The analytical stability and throughput of biomarker assays based on dried serum spots (DSS) are strongly dependent on the extraction process and determination method. In the present study, an on-line system based on supercritical fluid extraction-supercritical fluid chromatography coupled with tandem mass spectrometry (SFE-SFC/MS/MS) was established for analyzing the levels of disease biomarkers in DSS. METHODS: The chromatographic conditions were investigated using the ODS-EP, diol, and SIL-100A columns...
March 23, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28331418/optimization-of-pcr-condition-the-first-study-of-high-resolution-melting-technique-for-screening-of-apoa1-variance
#9
Hesty Wahyuningsih, Ferdy K Cayami, Udin Bahrudin, Mochamad A Sobirin, Farmaditya Ep Mundhofir, Sultana Mh Faradz, Ichiro Hisatome
BACKGROUND: High resolution melting (HRM) is a post-PCR technique for variant screening and genotyping based on the different melting points of DNA fragments. The advantages of this technique are that it is fast, simple, and efficient and has a high output, particularly for screening of a large number of samples. APOA1 encodes apolipoprotein A1 (apoA1) which is a major component of high density lipoprotein cholesterol (HDL-C). This study aimed to obtain an optimal quantitative polymerase chain reaction (qPCR)-HRM condition for screening of APOA1 variance...
March 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28330073/cladosporium-cladosporioides-from-the-perspectives-of-medical-and-biotechnological-approaches
#10
REVIEW
Manaf AlMatar, Essam A Makky
Fungi are important natural product sources that have enormous potential for the production of novel compounds for use in pharmacology, agricultural applications and industry. Compared with other natural sources such as plants, fungi are highly diverse but understudied. However, research on Cladosporium cladosporioides revealed the existence of bioactive products such as p-methylbenzoic acid, ergosterol peroxide (EP) and calphostin C as well as enzymes including pectin methylesterase (PME), polygalacturonase (PG) and chlorpyrifos hydrolase...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28325537/midline-extraperitoneal-approach-to-retroperitoneal-lymph-node-dissection-in-testicular-cancer-minimizing-surgical-morbidity
#11
Sumeet Syan-Bhanvadia, Soroush T Bazargani, Thomas G Clifford, Jie Cai, Gus Miranda, Siamak Daneshmand
BACKGROUND: Retroperitoneal lymph node dissection (RPLND) is an important component of the management of testicular germ cell tumor (GCT) but carries significant surgical morbidity. OBJECTIVE: To describe our experience with a midline extraperitoneal (EP) approach to RPLND for seminomatous and nonseminomatous GCT. DESIGN, SETTING, AND PARTICIPANTS: From 2010 to 2015, 122 consecutive patients underwent RPLND from a prospective database. Patients requiring aortic resection or retrocrural dissection or with intraperitoneal disease were excluded...
March 18, 2017: European Urology
https://www.readbyqxmd.com/read/28324936/a-preliminary-study-on-multi-wavelength-ppg-based-pulse-transit-time-detection-for-cuffless-blood-pressure-measurement
#12
Jing Liu, Yuan-Ting Zhang, Xiao-Rong Ding, Wen-Xuan Dai, Ni Zhao
Pulse transit time (PTT) has been widely studied as an index of blood pressure (BP) changes. In recent years, some prototypes of PTT-based wearable BP measurement devices have been developed, which can relieve users from the discomfort caused by the inflating cuff used in auscultatory and oscillometric BP measurement techniques. However, in the common practice for PTT detection, multi-site sensor implementation on human body is required, making it difficult for the integration of wearable devices. Since multi-wavelength (MW) photoplethysmogram (PPG) signals carry blood pulsation information of different blood vessels embedded in different skin depths, the time difference between different wavelength PPG signals collected at the same body site can be treated as a special PTT on a short length of blood vessels beneath the skin...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322885/fluoride-concentration-in-saliva-and-biofilm-fluid-following-the-application-of-three-fluoride-varnishes
#13
L Al Dehailan, F Lippert, C González-Cabezas, G J Eckert, E A Martinez-Mier
OBJECTIVE: Most of the commercially available fluoride varnishes (FV) have not been evaluated for their cariostatic properties. Consequently, the aim of this in vivo study was to investigate intra-oral fluoride retention and clearance patterns from three different FV. METHODS: Eighteen subjects (7-11 years) participated in a laboratory analyst-blinded, randomized, crossover study comparing the ability of 5% sodium fluoride varnishes (CavityShield-CS, Enamel Pro-EP, Vanish-V) to enhance fluoride concentrations in biofilm fluid, centrifuged and whole saliva over a period of 48h after a single FV application...
March 16, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28322837/role-of-prostanoid-ep3-1-receptors-in-mechanisms-of-emesis-and-defaecation-in-ferrets
#14
Kelvin K W Kan, Man K Wai, Robert L Jones, John A Rudd
Prostanoid EP receptor agonists are used for a number of clinical indications but may be associated with gastric disturbance. In the present studies we used the ferret and sulprostone (30µg/kg, i.p.) to investigate the role of EP3/1 receptors in mechanisms of emesis and defaecation. The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0...
March 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28322758/increased-seat-dump-angle-in-a-manual-wheelchair-is-associated-with-changes-in-thoracolumbar-lordosis-and-scapular-kinematics-during-propulsion
#15
Beth A Cloud, Kristin D Zhao, Arin M Ellingson, Ahmad Nassr, Anthony J Windebank, Kai-Nan An
OBJECTIVE: To quantify and compare spinal curvature and shoulder kinematics throughout the manual wheelchair propulsion cycle for individuals with spinal cord injury (SCI) who were seated at 2 different seat dump angles. DESIGN: Single-group, repeated-measures study. SETTING: Academic medical center. PARTICIPANTS: Twenty-eight individuals completed the telephone screening; 21 were eligible and completed the study. INTERVENTIONS: Participants' personal manual wheelchairs were modified to have seat dump angles of 0° or 14°, with a vertical backrest...
March 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28322468/effect-of-stage-based-education-provided-by-dedicated-dietitians-on-hyperphosphataemic-haemodialysis-patients-results-from-the-nutrition-education-for-management-of-osteodystrophy-randomised-controlled-trial
#16
R Rizk, M Karavetian, M Hiligsmann, S M A A Evers
BACKGROUND: The Nutrition Education for Management of Osteodystrophy trial showed that stage-based nutrition education by dedicated dietitians surpasses existing practices in Lebanon with respect to lowering serum phosphorus among general haemodialysis patients. The present study explores the effect of nutrition education specifically on hyperphosphataemic patients from this trial. METHODS: Hyperphosphataemic haemodialysis patients were allocated to a dedicated dietitian (DD), a trained hospital dietitian (THD) and existing practice (EP) protocols...
March 21, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28321227/co-expression-with-the-type-3-secretion-chaperone-cest-from-enterohemorrhagic-e-coli-increases-accumulation-of-recombinant-tir-in-plant-chloroplasts
#17
Jacqueline MacDonald, Sean Miletic, Typhanie Gaildry, Adam Chin-Fatt, Rima Menassa
Type 3 secretion systems (T3SSs) are utilized by pathogenic Escherichia coli to infect their hosts and many proteins from these systems are affected by chaperones specific to T3SS-containing bacteria. Toward developing a recombinant vaccine against enterohaemorrhagic E. coli (EHEC), we expressed recombinant T3SS and related proteins from predominant EHEC serotypes in Nicotiana chloroplasts. Nicotiana benthamiana were transiently transformed to express chloroplast-targeted Tir, NleA, and EspD from the EHEC serotype O157:H7; a fusion of EspA proteins from serotypes O157:H7 and O26:H11; and a fusion of epitopes of Tir (Tir-ep) from serotypes O157:H7, O26:H11, O45:H2, and O111:H8...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28320590/multitep-platform-based-dna-epitope-vaccine-targeting-n-terminus-of-tau-induces-strong-immune-responses-and-reduces-tau-pathology-in-thy-tau22-mice
#18
Hayk Davtyan, Wesley W Chen, Karen Zagorski, Joy Davis, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Michael G Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikyan
BACKGROUND: By the time clinical symptoms of Alzheimer's disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating, further accelerating disease progression. Over the last decade several groups have tested the efficacy of protein-based anti-tau immunotherapeutics in various animal models of tauopathy. Here we report on the immunological and therapeutic potency of the first anti-tau DNA vaccine based on the MultiTEP platform, AV-1980D, in THY-Tau22 transgenic mice...
March 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28319569/survivin-expression-in-simple-endometrial-polyps-and-tamoxifen-associated-endometrial-polyps
#19
Ayse F Gokmen Karasu, Fatma C Sonmez, Serdar Aydin, Ilknur Adanir, Mustafa Marasli, Gulsah K Ilhan
Endometrial polyps are benign pathologies originating as localized overgrowths of basal endometrium. Risk factors include endogenous and exogenous estrogen excess and tamoxifen (TAM) exposure. Our main objective was to investigate the role of an apoptosis-inhibiting protein, survivin, in endometrial polyps. We performed a cross-sectional, analytical study; our samples were obtained from the archives of Department of Pathology. Sixty samples were included, comprising 20 TAM polyps, 20 simple endometrial polyps, and 20 cases of simple endometrial hyperplasia without atypia not associated with TAM use...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28319281/successful-secukinumab-treatment-of-generalized-pustular-psoriasis-and-erythrodermic-psoriasis
#20
C Mugheddu, L Atzori, A Lappi, M Pau, S Murgia, F Rongioletti
Erythrodermic psoriasis (EP) and generalized pustular psoriasis (GPP) are the most severe forms of psoriasis, resulting in significant morbidity and even mortality (1) . There are few evidence-based data on their treatment (2,3) . Secukinumab, a fully human anti-IL-17A monoclonal antibody, demonstrated strong efficacy in treating moderate to severe plaque-type psoriasis (4,5) . This article is protected by copyright. All rights reserved.
March 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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