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https://www.readbyqxmd.com/read/29774876/-clinicopathological-features-for-epithelioid-glioblastoma-a-newly-defined-tumor-by-the-2016-world-health-organization-classification-of-tumors-of-the-central-nervous-system
#1
Juan Li, Xuebing Ling, Mingyao Lai, Qingjun Hu, Changguo Shan, Linbo Cai
To retrospectively summarize the clinicopathological features of epithelioid glioblastoma (Ep-GBM) and to explore new treatment for Ep-GBM.
 Methods: The clinical data of 13 patients with Ep-GBM, who were treated in our department from March 2016 to July 2017, were retrospectively analyzed. The clinicopathological features were summarized and the efficacy was evaluated.
 Results: The positive rate of BRAFV600E mutant and INI-1 was 76.9% (10/13) and 80% (8/10), respectively, while the median Ki-67 index was 30%...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29773138/multiplex-hydrolysis-probe-assay-for-the-simultaneous-detection-of-theileria-equi-and-babesia-caballi-infections-in-equids
#2
Raksha V Bhoora, Ronel Pienaar, Frances Cornelius, Antoinette Josemans, Olivier Matthee, Ratselane Marumo, Christo Troskie, Ben J Mans
Quantitative real-time PCR assays previously developed for the detection of Theileria equi and Babesia caballi, were combined in a single multiplex TaqMan qPCR platform for the simultaneous detection of both heamoprotozoan parasites in equids. The multiplex equine piroplasmosis (M-EP) qPCR assay was shown to be efficient and specific. The detection limit was determined to be 1.4 × 10-4 % parasitized erythrocytes (PE) for T. equi and 2.8 × 10-4 % PE for B. caballi. The effect of differential DNA concentrations on the outcome of the M-EP qPCR for each target species was also investigated...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29770848/imaging-biomarkers-from-multiparametric-magnetic-resonance-imaging-are-associated-with-survival-outcomes-in-patients-with-brain-metastases-from-breast-cancer
#3
Bang-Bin Chen, Yen-Shen Lu, Chih-Wei Yu, Ching-Hung Lin, Tom Wei-Wu Chen, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih
OBJECTIVES: The aim of this study is to investigate the correlation of survival outcomes with imaging biomarkers from multiparametric magnetic resonance imaging (MRI) in patients with brain metastases from breast cancer (BMBC). METHODS: This study was approved by the institutional review board. Twenty-two patients with BMBC who underwent treatment involving bevacizumab on day 1, etoposide on days 2-4, and cisplatin on day 2 in 21-day cycles were prospectively enrolled for a phase II study...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29770569/frontal-cortical-thickness-correlates-positively-with-impulsivity-in-early-psychosis-male-patients
#4
Philipp S Baumann, Paul Klauser, Alessandra Griffa, Philippe Golay, Julie Palix, Luis Alameda, Valérie Moulin, Patric Hagmann, Kim Q Do, Philippe Conus
AIM: Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophrenia have been poorly investigated especially in young adults, the aim of this study was to investigate the relationship between impulsivity and cortical thickness in early psychosis (EP) patients. METHOD: A total of 17 male subjects in the early phase of psychosis were recruited...
May 17, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29766270/parasitological-and-molecular-diagnostic-of-a-clinical-babesia-caballi-outbreak-in-southern-romania
#5
Mariana Ionita, Isabela Madalina Nicorescu, Kurt Pfister, Ioan Liviu Mitrea
Equine piroplasmosis (EP) is a tick-borne disease of equids caused by Babesia caballi and/or Theileria equi, which is endemic in many tropical and temperate areas of the world. However, clinical outbreaks of EP in Romania during the last decades have not been reported Therefore, the aim of this paper is (i) to describe a clinical B. caballi outbreak in horses on several farms in Southern Romania using a diagnostic and therapeutic approach and (ii) the molecular diagnostic of EP in an endemic area of Romania...
May 15, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29765749/naloxegol-hydrogen-oxalate-displaying-a-hydrogen-bonded-layer-structure
#6
Thomas Gelbrich, Christoph Langes, Marijan Stefinovic, Ulrich J Griesser
In the salt (5α,6α)-6-[(2,5,8,11,14,17,20-hepta-oxadocosan-22-yl)-oxy]-3,14-dihy-droxy-17-(prop-2-en-1-yl)-4,5-ep-oxy-morphinan-17-ium hydrogen oxalate, C34 H54 NO11 + ·C2 HO4 - the polyether unit of the naloxegol cation adopts the shape of a squashed open letter 'O'. In the crystal, the hydrogen oxalate anions are linked into a chain by O-H⋯O hydrogen bonds. Each naloxegol unit is hydrogen bonded to three hydrogen oxalate ions via two O-H⋯O and one N-H⋯O inter-actions. The resulting hydrogen-bonded two-dimensional layer structure is 3,5-connected and has the 3,5 L50 topology...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765522/establishment-of-preclinical-chemotherapy-models-for-gastroenteropancreatic-neuroendocrine-carcinoma
#7
Akihiro Ohmoto, Masami Suzuki, Erina Takai, Hirofumi Rokutan, Yuko Fujiwara, Chigusa Morizane, Kazuyoshi Yanagihara, Tatsuhiro Shibata, Shinichi Yachida
Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a rare and devastating malignancy, and preclinical studies are needed to evaluate potential therapeutic regimens. Here, we examined the antitumor effects of cisplatin (CDDP), etoposide (ETP) and irinotecan (CPT-11) and their combinations on GEP-NEC using three small-cell GEP-NEC cell lines (pancreatic NEC, A99; esophageal NEC, TYUC-1; duodenum NEC, TCC-NECT-2). In vitro studies were conducted using cell viability assays. In vivo experiments were conducted in mice inoculated with A99 or TCC-NECT-2 and treated with no agent, CDDP, CDDP+ETP (EP) or CDDP+CPT-11 (IP)...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764229/use-of-surgical-hemostatic-powder-for-ep-device-implantation-reduces-postoperative-rates-of-pocket-hematoma-and-infection
#8
Olga Reynbakh, Philippe Akhrass, Nektarios Souvaliotis, Chaithanya K Pamidimukala, Hasnun Nahar, Joseph Bastawrose, Pierre Boktor, Joshua E Aziz, Davendra Mehta, Emad F Aziz
BACKGROUND: Surgical site bleeding and infection are potential complications after EP device implantation procedures. To date, there is a wide variety of tools for management of intraoperative bleeding but it still remains unclear what methods are preferred. OBJECTIVE: The aim of our study is to compare the rate of complications in patients who underwent Cardiac Implantable Electronic devices (CIED) implantation utilizing Arista as a hemostatic agent to the rate of complications in those patients who underwent standard procedure protocol without Arista...
May 15, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29763840/the-risk-of-neurodevelopmental-disorders-at-age-10-years-associated-with-blood-concentrations-of-interleukins-4-and-10-during-the-first-postnatal-month-of-children-born-extremely-preterm
#9
Alan Leviton, Robert M Joseph, Elizabeth N Allred, Raina N Fichorova, T Michael O'Shea, Karl K C Kuban, Olaf Dammann
BACKGROUND: Interleukin (IL)-4 and IL-10 are viewed mainly as anti-inflammatory cytokines. Yet, high concentrations have also been associated with inflammation-related diseases in newborns. METHODS: We measured the concentrations of IL-4 and IL-10, as well as IL-8 and ICAM-1 in blood specimens collected on postnatal day 21 (N = 555), day 28 (N = 521), and both days 21 and 28 (N = 449) from children born extremely preterm (EP) (<28 weeks gestation) who at age 10 years had a DAS-II IQ Z-score > -2 (which approximates a score of >70) and the following assessments, CCC-2, and CSI-4, DAS-II, NEPSY-II, OWLS-II, SCQ, and WIAT-III...
May 12, 2018: Cytokine
https://www.readbyqxmd.com/read/29761891/processed-electroencephalogram-and-evoked-potential-techniques-for-amelioration-of-postoperative-delirium-and-cognitive-dysfunction-following-non-cardiac-and-non-neurosurgical-procedures-in-adults
#10
REVIEW
Yodying Punjasawadwong, Waraporn Chau-In, Malinee Laopaiboon, Sirivimol Punjasawadwong, Pathomporn Pin-On
BACKGROUND: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) may complicate a patient's postoperative recovery in several ways. Monitoring of processed electroencephalogram (EEG) or evoked potential (EP) indices may prevent or minimize POD and POCD, probably through optimization of anaesthetic doses. OBJECTIVES: To assess whether the use of processed EEG or auditory evoked potential (AEP) indices (bispectral index (BIS), narcotrend index, cerebral state index, state entropy and response entropy, patient state index, index of consciousness, A-line autoregressive index, and auditory evoked potentials (AEP index)) as guides to anaesthetic delivery can reduce the risk of POD and POCD in non-cardiac surgical or non-neurosurgical adult patients undergoing general anaesthesia compared with standard practice where only clinical signs are used...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29760984/the-value-of-ultrahigh-resolution-oct-in-dermatology-delineating-the-dermo-epidermal-junction-capillaries-in-the-dermal-papillae-and-vellus-hairs
#11
Niels Møller Israelsen, Michael Maria, Mette Mogensen, Sophie Bojesen, Mikkel Jensen, Merete Haedersdal, Adrian Podoleanu, Ole Bang
Optical coherence tomography (OCT) imaging of the skin is gaining recognition and is increasingly applied to dermatological research. A key dermatological parameter inferred from an OCT image is the epidermal (Ep) thickness as a thickened Ep can be an indicator of a skin disease. Agreement in the literature on the signal characters of Ep and the subjacent skin layer, the dermis (D), is evident. Ambiguities of the OCT signal interpretation in the literature is however seen for the transition region between the Ep and D, which from histology is known as the dermo-epidermal junction (DEJ); a distinct junction comprised of the lower surface of a single cell layer in epidermis (the stratum basale) connected to an even thinner membrane (the basement membrane)...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760840/clinical-ultrasound-is-safe-and-highly-specific-for-acute-appendicitis-in-moderate-to-high-pre-test-probability-patients
#12
Daniel Corson-Knowles, Frances M Russell
Introduction: Clinical ultrasound (CUS) is highly specific for the diagnosis of acute appendicitis but is operator-dependent. The goal of this study was to determine if a heterogeneous group of emergency physicians (EP) could diagnose acute appendicitis on CUS in patients with a moderate to high pre-test probability. Methods: This was a prospective, observational study of a convenience sample of adult and pediatric patients with suspected appendicitis. Sonographers received a structured, 20-minute CUS training on appendicitis prior to patient enrollment...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29760646/dgcr8-promotes-neural-progenitor-expansion-and-represses-neurogenesis-in-the-mouse-embryonic-neocortex
#13
Nadin Hoffmann, Stefan C Weise, Federica Marinaro, Tanja Vogel, Davide De Pietri Tonelli
DGCR8 and DROSHA are the minimal functional core of the Microprocessor complex essential for biogenesis of canonical microRNAs and for the processing of other RNAs. Conditional deletion of Dgcr8 and Drosha in the murine telencephalon indicated that these proteins exert crucial functions in corticogenesis. The identification of mechanisms of DGCR8- or DROSHA-dependent regulation of gene expression in conditional knockout mice are often complicated by massive apoptosis. Here, to investigate DGCR8 functions on amplification/differentiation of neural progenitors cells (NPCs) in corticogenesis, we overexpress Dgcr8 in the mouse telencephalon, by in utero electroporation ( IU Ep)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29760181/corticosterone-signaling-and-a-lateral-habenula-ventral-tegmental-area-circuit-modulate-compulsive-self-injurious-behavior-in-a-rat-model
#14
Yujie Guo, Xun Tang, Jichuan Zhang, Sen Jin, Jinnan Li, Lufeng Ding, Keming Zhang, Chaoyu Yang, Hua Zhou, Xiaobin He, Fuqiang Xu, Guo-Qiang Bi, Lin Xu, Pak-Ming Lau
Self-injurious behavior (SIB) is commonly observed in patients with neuropsychiatric disorders, as well as nonclinical populations with stress related mental health problems. However, the exact circuitry mechanisms underlying SIB have remained unclear. Here we established a rat model of SIB with bilateral injection of muscimol into entopeduncular nucleus (EP). Following the muscimol injection, the male rats exhibited stereotypic self-biting behavior that lasted for hours and often resulted in wounds of various severities, in a dose-dependent manner...
May 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29759676/outcomes-associated-with-electrical-cardioversion-for-atrial-fibrillation-when-performed-autonomously-by-an-advanced-practice-provider
#15
Theresa A Strzelczyk, Rachel M Kaplan, Meena Medler, Bradley P Knight
OBJECTIVES: This study sought to determine the feasibility, safety, and efficacy of elective electrical cardioversion (CV) for atrial fibrillation (AF) when performed autonomously by a trained advanced practice provider (APP) using a guideline-directed protocol. BACKGROUND: APPs have emerged as an integral part of the cardiovascular team. METHODS: A licensed advanced practice nurse-clinical nurse specialist was trained and obtained credentials to perform CVs...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29758617/channel-optimization-of-high-intensity-laser-beams-in-millimeter-scale-plasmas
#16
L Ceurvorst, A Savin, N Ratan, M F Kasim, J Sadler, P A Norreys, H Habara, K A Tanaka, S Zhang, M S Wei, S Ivancic, D H Froula, W Theobald
Channeling experiments were performed at the OMEGA EP facility using relativistic intensity (>10^{18}W/cm^{2}) kilojoule laser pulses through large density scale length (∼390-570 μm) laser-produced plasmas, demonstrating the effects of the pulse's focal location and intensity as well as the plasma's temperature on the resulting channel formation. The results show deeper channeling when focused into hot plasmas and at lower densities, as expected. However, contrary to previous large-scale particle-in-cell studies, the results also indicate deeper penetration by short (10 ps), intense pulses compared to their longer-duration equivalents...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29758359/probing-flecainide-block-of-i-na-using-human-pluripotent-stem-cell-derived-ventricular-cardiomyocytes-adapted-to-automated-patch-clamping-and-2d-monolayers
#17
Lin Geng, Chi-Wing Kong, Andy O T Won, Angie Man-Yee Shum, Maggie Z Y Chow, Hui Che, Chenzi Zhang, Ka-Long Yau, Camie W Chan, Wendy Keung, Ronald A Li
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are emerging tools for applications such as drug discovery and screening for pro-arrhythmogenicity and cardiotoxicity as leading causes for drug attrition. Understanding the electrophysiology (EP) of hPSC-CMs is essential but conventional manual patch-clamping is highly laborious and low-throughput. Here we adapted hPSC-CMs derived from two human embryonic stem cell (hESC) lines, HES2 and H7, for a 16-channel automated planar-recording approach for single-cell EP characterization...
May 11, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29755017/endoscopic-papillectomy-of-benign-ampullary-lesions-outcomes-from-a-multicenter-study
#18
Tan Attila, Erkan Parlak, Emrah Alper, Selçuk Dişibeyaz, Bahattin Çiçek, Bülent Ödemiş
BACKGROUND/AIMS: Endoscopic papillectomy (EP) has emerged as an alternative to surgery in the management of ampullary lesions. The aim of this study is to evaluate feasibility, efficacy, safety, outcome, and impact of EP in the management of benign ampullary lesions. MATERIALS AND METHODS: This is a multicenter, retrospective study of 44 patients who had EP of benign ampullary lesions. RESULTS: Over the 11-year period, 44 (55.7%) of 79 patients underwent EP for benign ampullary lesions...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29753182/personalized-computational-modeling-of-left-atrial-geometry-and-transmural-myofiber-architecture
#19
Thomas E Fastl, Catalina Tobon-Gomez, Andrew Crozier, John Whitaker, Ronak Rajani, Karen P McCarthy, Damian Sanchez-Quintana, Siew Y Ho, Mark D O'Neill, Gernot Plank, Martin J Bishop, Steven A Niederer
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by complete absence of coordinated atrial contraction and is associated with an increased morbidity and mortality. Personalized computational modeling provides a novel framework for integrating and interpreting the role of atrial electrophysiology (EP) including the underlying anatomy and microstructure in the development and sustenance of AF. Coronary computed tomography angiography data were segmented using a statistics-based approach and the smoothed voxel representations were discretized into high-resolution tetrahedral finite element (FE) meshes...
April 5, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29752406/the-prostaglandin-e-2-receptor-ep3-controls-cc-chemokine-ligand-mediated-neuropathic-pain-induced-by-mechanical-nerve-damage
#20
Elsa-Marie Treutlein, Katharina Kern, Andreas Weigert, Neda Tarighi, Claus-Dieter Schuh, Rolf M Nüsing, Yannick Schreiber, Nerea Ferreirós, Bernhard Brüne, Gerd Geisslinger, Sandra Pierre, Klaus Scholich
Prostaglandin (PG) E2 is an important lipid mediator that is involved in several pathophysiological processes contributing to fever, inflammation and pain. Previous studies have shown that early and continuous application of non-steroidal anti-inflammatory drugs significantly reduces pain behavior in the spared nerve injury (SNI) model for trauma-induced neuropathic pain. However, the role of PGE2 and its receptors in the development and maintenance of neuropathic pain is incompletely understood, but may help inform strategies for pain management...
May 11, 2018: Journal of Biological Chemistry
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