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https://www.readbyqxmd.com/read/29353319/management-strategies-for-noncardiac-surgery-following-a-coronary-artery-event
#1
REVIEW
Thomas F Whayne, Sibu P Saha
PURPOSE OF REVIEW: Coronary artery event includes acute coronary syndrome (ACS), percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) surgery. Following such an event, risk of noncardiac surgery is increased. Of major concern is what can make this surgery safer? RECENT FINDINGS: High functional capacity improves cardiovascular (CV) risk; at least 4.0 metabolic equivalents (METs) on stress test are favorable. Risk scores can suggest need for further evaluation...
January 20, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29353224/coronary-microvascular-dysfunction-may-be-related-to-igf-1-in-acromegalic-patients-and-can-be-restored-by-therapy
#2
Sara Tellatin, Pietro Maffei, Elena Osto, Francesca Dassie, Giulia Famoso, Roberta Montisci, Chiara Martini, Francesco Fallo, Martina Perazzolo Marra, Roberto Mioni, Sabino Iliceto, Roberto Vettor, Francesco Tona
BACKGROUND AND AIMS: Acromegaly increases the risk of cardiovascular mortality. Data on the cardiovascular risk in asymptomatic acromegaly are limited. In particular, data on coronary microvascular abnormalities are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic acromegaly. METHODS: We studied 40 acromegalic patients (23 male, age 52 ± 11 years) without clinical evidence of cardiovascular disease, and 40 control subjects matched for age and sex...
December 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29352859/is-selective-5-ht1f-receptor-agonism-an-entity-apart-from-that-of-the-triptans-in-antimigraine-therapy
#3
REVIEW
Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Carlos M Villalón, Antoinette MaassenVanDenBrink
Migraine is a neurovascular disorder that involves activation of the trigeminovascular system and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP). The gold standard for acute migraine treatment are the triptans, 5-HT1B/1D/(1F) receptor agonists. Their actions are thought to be mediated through activation of: (i) 5-HT1B receptors in cranial blood vessels with subsequent cranial vasoconstriction; (ii) prejunctional 5-HT1D receptors on trigeminal fibers that inhibit trigeminal CGRP release; and (iii) 5-HT1B/1D/1F receptors in central nervous system involved in (anti)nociceptive modulation...
January 17, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29352760/endothelial-function-estimated-by-digital-reactive-hyperemia-in-patients-with-atherosclerotic-risk-factors-or-coronary-artery-disease
#4
Jeehoon Kang, Hack-Lyoung Kim, Jae-Bin Seo, Jin-Yong Lee, Min-Kyong Moon, Woo-Young Chung
Due to the complex profile of atherosclerotic risk factors, an integrated analysis of a specific individual is difficult. Endothelial function reflects a composite of various risk factors, and may be used as an optimal tool to estimate the overall atherosclerotic risk. In this study, we investigated the value of digital Reactive Hyperemia Index (RHI) in an actual population with multiple atherosclerotic risk factors or coronary artery disease (CAD). A total of 417 patients from the Seoul National University Boramae Medical Center RHI registry were enrolled in this study...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29352692/ckd-epi-versus-cockcroft-gault-formula-for-predicting-contrast-induced-nephropathy-following-percutaneous-coronary-intervention-in-patients-without-significant-renal-impairment
#5
Mário B G Nunes, Antônio C Filho, Valéria R C Alvares, Rafael Moreno, Edgar Lamas, Vitor Loures, Daniel Chamié, Alexandre Abizaid
INTRODUCTION: Individuals with glomerular filtration rate (GFR) ≥60 ml/min/1.73 m2 estimated by the Cockcroft-Gault formula (CG) who undergo percutaneous coronary intervention (PCI) frequently develop contrast-induced nephropathy (CIN). This study aimed to assess whether individuals with significant renal impairment assessed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, but not by CG, more often develop CIN following PCI than those without renal impairment by either formula...
January 15, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29352381/myocardial-perfusion-in-patients-with-suspected-coronary-artery-disease-comparison-between-320-mdct-and-rubidium-82-pet
#6
Roberto Nery Dantas, Antonildes Nascimento Assuncao, Ismar Aguiar Marques, Mateus Guimaraes Fahel, Cesar Higa Nomura, Luiz Francisco Rodrigues Avila, Maria Clementina Pinto Giorgi, Jose Soares, Jose Claudio Meneghetti, Jose Rodrigues Parga
OBJECTIVES: Despite advances in non-invasive myocardial perfusion imaging (MPI) evaluation, computed tomography (CT) multiphase MPI protocols have not yet been compared with the highly accurate rubidium-82 positron emission tomography (82RbPET) MPI. Thus, this study aimed to evaluate agreement between 82RbPET and 320-detector row CT (320-CT) MPI using a multiphase protocol in suspected CAD patients. METHODS: Forty-four patients referred for MPI evaluation were prospectively enrolled and underwent dipyridamole stress 82RbPET and multiphase 320-CT MPI (five consecutive volumetric acquisitions during stress)...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29352380/integrated-prediction-of-lesion-specific-ischaemia-from-quantitative-coronary-ct-angiography-using-machine-learning-a-multicentre-study
#7
Damini Dey, Sara Gaur, Kristian A Ovrehus, Piotr J Slomka, Julian Betancur, Markus Goeller, Michaela M Hell, Heidi Gransar, Daniel S Berman, Stephan Achenbach, Hans Erik Botker, Jesper Moller Jensen, Jens Flensted Lassen, Bjarne Linde Norgaard
OBJECTIVES: We aimed to investigate if lesion-specific ischaemia by invasive fractional flow reserve (FFR) can be predicted by an integrated machine learning (ML) ischaemia risk score from quantitative plaque measures from coronary computed tomography angiography (CTA). METHODS: In a multicentre trial of 254 patients, CTA and invasive coronary angiography were performed, with FFR in 484 vessels. CTA data sets were analysed by semi-automated software to quantify stenosis and non-calcified (NCP), low-density NCP (LD-NCP, < 30 HU), calcified and total plaque volumes, contrast density difference (CDD, maximum difference in luminal attenuation per unit area) and plaque length...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29351856/high-density-lipoprotein-with-apolipoprotein-c-iii-is-associated-with-carotid-intima-media-thickness-among-generally-healthy-individuals
#8
Rain Yamamoto, Frank M Sacks, Frank B Hu, Bernard Rosner, Jeremy D Furtado, Sarah A Aroner, Ele Ferrannini, Simona Baldi, Michaela Kozakova, Beverley Balkau, Andrea Natali, Majken K Jensen
BACKGROUND AND AIMS: About 6-7% of high density lipoprotein (HDL) has a protein called apolipoprotein (apo) C-III that regulates lipoprotein metabolism and can provoke an inflammatory response. HDL without apoC-III is inversely associated with coronary heart disease (CHD), whereas HDL with apoC-III is directly associated with CHD. We investigated how the presence of apoC-III affects the association between HDL and early stages of atherosclerosis measured as carotid intima-media thickness (cIMT)...
January 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29351794/metabolic-syndrome-severity-is-significantly-associated-with-future-coronary-heart-disease-in-type-2-diabetes
#9
Matthew J Gurka, Yi Guo, Stephanie L Filipp, Mark D DeBoer
BACKGROUND: The severity of the metabolic syndrome (MetS) is significantly associated with future coronary heart disease (CHD) among individuals without baseline Type 2 diabetes. However, the validity of assessing MetS severity among individuals with diabetes is unknown. OBJECTIVE: To assess for differences in MetS severity by timing of Type 2 diabetes diagnosis and to assess for associations between MetS severity and future CHD among individuals with diabetes. METHODS: We analyzed data from participants of the Atherosclerosis Risk in Communities study, including 1419 with- and 7241 without diabetes, followed during 4 visits and adjudicated CHD diagnoses over a 20-year period...
January 19, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29351744/risk-factors-for-first-time-acute-myocardial-infarction-patients-in-trinidad
#10
M Bahall, T Seemungal, G Legall
BACKGROUND: The relative importance of coronary artery disease (CAD) risk varies globally. The aim of this study was to determine CAD risk factors for acute myocardial infarction (AMI) among patients in public health care institutions in Trinidad using a case-control type study design. METHODS: The sample comprised 251 AMI patients hospitalized between March 1, 2011 and April 30, 2012 and 464 age- and sex-matched non-AMI patients with no terminal or life-threatening illness and who did not undergo treatment for CAD...
January 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29351739/a-study-of-the-association-of-rs12040273-with-susceptibility-and-severity-of-coronary-artery-disease-in-a-chinese-han-population
#11
Bo Yang, Shan Yan, Jianjun Yan, Yafei Li, Mohammad Reeaze Khurwolah, Liansheng Wang, Zhong Chen
BACKGROUND: The single nucleotide polymorphism (SNP) rs12040273, a variant of UDP-N-acetylgalactosamine, polypeptide GalNAc-transferase 2, has recently been reported to be significantly associated with development of carotid artery intima-media thickness (IMT) in a Chinese population based on a genome-wide association study. Because IMT is a potent marker of coronary artery disease (CAD), the aim of this study was to evaluate the relation of rs12040273 to susceptibility and severity of CAD in a Chinese Han population...
January 19, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29351461/exercise-training-induces-enos-coupling-and-restores-relaxation-in-coronary-arteries-of-heart-failure-rats
#12
Gisele Kruger Couto, Suliana Mesquita Paula, Igor L Gomes-Santos, Carlos Eduardo Negrão, Luciana Venturini Rossoni
Exercise training (ET) has emerged as a non-pharmacological therapy for cardiovascular diseases because of its helpful milieu for improving vascular function. The aim of the present study was to assess whether ET reverses the alterations in vascular reactivity observed in heart failure (HF)-related coronary arteries and to elucidate the molecular mechanisms involved in these adjustments. Male Wistar rats were subjected to either coronary artery ligation or sham operation (SO). Four weeks after the surgery, the rats were divided into two groups: untrained HF (UHF) and exercise-trained HF (THF)...
January 5, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351086/active-phytoconstituents-for-diabetes-management-a-review
#13
Rajnish Gupta
Diabetes is a metabolic syndrome increasing rapidly due to occupational stress, lack of physical activity, sedentary lifestyle and increasing occurrence of obesity, associated with rapidly growing urbanization and industrialization. Due to erroneous carbohydrate metabolism, diabetics are more prone to chronic complications like nephropathy, neuropathy, retinopathy, coronary artery disease and peripheral arterial disease resulting in tissue damage. Current treatment protocols to these problems produce more serious adverse effects and are costly too...
January 19, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29351006/associations-between-microalbuminuria-and-parameters-of-flow-mediated-vasodilatation-obtained-by-continuous-measurement-approaches
#14
Rie Koyoshi, Yuka Hitaka-Yoshimine, Yuhei Shiga, Takashi Kuwano, Makoto Sugihara, Amane Ike, Atsushi Iwata, Hideto Sako, Natsumi Morito, Akira Kawamura, Shin-Ichiro Miura
The associations between microalbuminuria and various parameters of flow-mediated vasodilatation (FMD) are not completely understood. We retrospectively analyzed 265 consecutive patients who underwent coronary angiography and in whom we could measure FMD and the urine albumin-creatinine ratio (UACR). Using 15 continuous measurement approaches, we measured FMD as the magnitude of the percentage change in the brachial artery diameter from baseline to peak (bFMD), the maximum FMD rate calculated as the maximal slope of dilation (FMD-MDR), and the integrated FMD response calculated as the area under the dilation curve during the 60- and 120-s dilation periods (FMD-AUC60 and FMD-AUC120)...
January 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29350660/rest-2d-speckle-tracking-echocardiography-may-be-a-sensitive-but-nonspecific-test-for-detection-of-significant-coronary-artery-disease
#15
Mohammad Parsa Mahjoob, Saeed Alipour Parsa, Asghar Mazarei, Morteza Safi, Isa Khaheshi, Shooka Esmaeeli
AIMS: To detect the significance of coronary artery disease in the patients, who are suspected, was assumed to be one of the advantages of 2D STE, as a novel non-invasive imaging modality with acceptable accuracy. METHODS: In this study, 216 patients who were suspected to have coronary artery disease and candidate for coronary angiography, underwent rest two-dimensional speckle tracking echocardiography (2D STE) and negative global systolic longitudinal strain was evaluated...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350382/risk-factors-for-adverse-outcomes-of-acute-coronary-syndrome-patients-single-center-experience-in-long-term-follow-up-of-treated-patients
#16
Marcin Grabowski, Krzysztof J Filipiak, Grzegorz Opolski, Renata Główczyńska, Monika Gawałko, Paweł Balsam, Andrzej Cacko, Zenon Huczek, Grzegorz Karpiński, Robert Kowalik, Franciszek Majstrak, Janusz Kochman
BACKGROUND: For patients experiencing an acute coronary syndrome (ACS), a crucial time to assess their prognosis and future management is at discharge from hospital. AIM: To identify patients' risk factors of mortality during post-discharge period following an ACS hospitalization. METHODS: We studied 672 consecutive ACS patients hospitalized and discharged alive between 2002 and 2004. The analysis was done in respect of the type of ACS, i...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350378/eq-5d-studies-in-cardiovascular-diseases-in-eight-central-and-eastern-european-countries-a-systematic-review-of-the-literature
#17
Paulina Batóg, Fanni Rencz, Márta Péntek, László Gulácsi, Krzysztof J Filipiak, Valentina Prevolnik Rupel, Judit Simon, Valentin Brodszky, Petra Baji, Jakub Závada, Guenka Petrova, Alexandru Rotar, Dominik Golicki
BACKGROUND: The measurement of health-related quality of life (HRQOL) by validated generic instruments, such as EQ-5D, becomes an increasingly important tool for the assessment of health care in a wide range of different diagnoses. AIM: To systematically review EQ-5D literature generated in cardiovascular diseases in eight selected Central and Eastern Europe (CEE) countries. METHODS: A structured literature search was conducted in MEDLINE, EMBASE, Web of Science, CINAHL, PsycINFO, the Cochrane Library and the EuroQol website up to November 2016...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350269/exome-analysis-in-34-sudden-unexplained-death-sud-victims-mainly-identified-variants-in-channelopathy-associated-genes
#18
Jacqueline Neubauer, Maria Rita Lecca, Giancarlo Russo, Christine Bartsch, Argelia Medeiros-Domingo, Wolfgang Berger, Cordula Haas
Sudden cardiac death (SCD) is one of the major causes of mortality worldwide, mostly involving coronary artery disease in the elderly. In contrary, sudden death events in young victims often represent the first manifestation of undetected genetic cardiac diseases, which remained without any symptoms during lifetime. Approximately 30% of these sudden death cases have no definite cardiac etiology after a comprehensive medicolegal investigation and are therefore termed as sudden unexplained death (SUD) cases. Advances in high-throughput sequencing approaches have provided an efficient diagnostic tool to identify likely pathogenic variants in cardiovascular disease-associated genes in otherwise autopsy-negative SUD cases...
January 19, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29350253/direct-transfer-of-stemi-patients-to-cardiac-catheterization-laboratory-prognostic-relevance-for-in-hospital-mortality
#19
M Ali, S A Lange, T Wittlinger, G Lehnert, S Behrend, B Ziadeh, K Ali, S Sakellaropoulos, G Ganchev, A G Rigopoulos, M Noutsias
BACKGROUND: Although the incidence of acute myocardial infarction and in-hospital mortality after ST-elevation myocardial infarction (STEMI) has declined substantially in countries that have established primary percutaneous coronary interventions (pPCI) over the past two decades, coronary artery disease remains a major cause of morbidity and mortality worldwide. We aimed to examine whether the direct transfer of STEMI patients to the cardiac catheterization laboratory (CCL) had a prognostic effect on in-hospital mortality in patients who underwent pPCI after STEMI...
January 19, 2018: Herz
https://www.readbyqxmd.com/read/29350061/the-adverse-effects-of-environmental-noise-exposure-on-oxidative-stress-and-cardiovascular-risk
#20
Thomas Münzel, Mette Sørensen, Frank P Schmidt, Erwin Schmidt, Sebastian Steven, Swenja Kröller-Schön, Andreas Daiber
Epidemiological studies have provided evidence that traffic noise exposure is linked to cardiovascular diseases such as arterial hypertension, myocardial infarction and stroke. Noise is a non-specific stressor that activates the autonomous nervous system and endocrine signaling. According to the noise reaction model introduced by Babisch and colleagues, chronic low levels of noise can cause so called non-auditory effects, such as disturbances of activity, sleep and communication, which can trigger a number of emotional responses, including annoyance and subsequent stress...
January 19, 2018: Antioxidants & Redox Signaling
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