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Antiarrhythics

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https://www.readbyqxmd.com/read/17113839/simultaneous-determination-of-ten-antiarrhythic-drugs-and-a-metabolite-in-human-plasma-by-liquid-chromatography-tandem-mass-spectrometry
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Shuijun Li, Gangyi Liu, Jingying Jia, Yun Liu, Cheng Pan, Chen Yu, Yongbao Cai, Jianying Ren
A simple, accurate and selective LC-MS/MS method was developed and validated for simultaneous quantification of ten antiarrhythic drugs (diltiazem, amiodarone, mexiletine, propranolol, sotalol, verapamil, bisoprolol, metoprolol, atenolol, carvedilol) and a metabolite (norverapamil) in human plasma. Plasma samples were simply pretreated with acetonitrile for deproteinization. Chromatographic separation was performed on a Capcell C(18) column (50mmx2.0mm, 5microm) using a gradient mixture of acetonitrile and water (both containing 0...
March 1, 2007: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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