María Sofía Amarilla, Leilane Glienke, Thaisy Munduruca Pires, Cristian Marcelo Sobarzo, Hernán Gustavo Oxilia, María Florencia Fulco, Marcelo Rodríguez Peña, María Belén Maio, Denisse Ferrer Viñals, Livia Lustig, Patricia Verónica Jacobo, María Susana Theas
Experimental autoimmune orchitis (EAO) is a well-established rodent model of organ-specific autoimmunity associated with infertility in which the testis immunohistopathology has been extensively studied. In contrast, analysis of testis biopsies from infertile patients associated with inflammation has been more limited. In this work, testicular biopsies from patients with idiopathic non-obstructive azoospermia diagnosed with hypospermatogenesis (HypoSp) [mild: n = 9, and severe: n = 11], with obstructive azoospermia and complete Sp (spermatogenesis) (control group, C, n = 9), and from Sertoli cell-only syndrome (SCOS, n = 9) were analyzed for the presence of immune cells, spermatogonia and Sertoli cell (SCs) alterations, and reproductive hormones levels...
April 19, 2024: Biology