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Azoospermia

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https://www.readbyqxmd.com/read/29441603/molecular-analysis-of-cag-repeat-length-of-the-androgen-receptor-gene-and-y-chromosome-microdeletions-among-jordanian-azoospermic-infertile-males
#1
O Batiha, S Haifawi, M Al-Smadi, G J Burghel, Z Naber, A M Elbetieha, K Bodoor, A Al Sumadi, S Swaidat, Y Jarun, A Abdelnour
Assisted reproductive technology is a common procedure which helps millions of couples who suffer fertility problems worldwide every year. Screening for genetic abnormalities prior to such procedure is very important to prevent the transmission of harmful genetic mutations to future generations. Microdeletions within the azoospermia factor (AZF) region of the Y chromosome and the expansion of the CAG trinucleotides in the androgen receptor (AR) gene are among the susceptible causes of male infertility in different ethnic groups...
February 14, 2018: Andrologia
https://www.readbyqxmd.com/read/29430151/azoospermia-factor-c-subregion-of-the-y-chromosome
#2
REVIEW
Mili Nailwal, Jenabhai B Chauhan
The azoospermia factor (AZF) region on the Y chromosome consists of genes required for spermatogenesis. Among the three subregions, the AZFc subregion located at the distal portion of AZF is the driver for genetic variation in Y chromosome. The candidate gene of AZFc is known as deleted in azoospermia gene, which is studied with interest because it is involved in germ cell development and most frequently deleted genes leading to oligozoospermia and azoospermia. Recently, two partial deletions in AZFc gr/gr and b2/b3 are characterized at the molecular level which showed homologous recombination between amplicons, affecting spermatogenesis process...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29419855/-clinical-report-of-testicular-hypoplasia-combined-with-21-hydroxylase-deficiency
#3
Bo Jiang, Dingyuan Ma, Huanhuan Chen, Xiaoyu Yang, Yugui Cui, Zhengfeng Xu, Jiayin Liu
OBJECTIVE To investigate the correlation of 21-hydroxylase deficiency (21-OHD) with male testicular dysplasia. METHODS Clinical data of 8 infertile males with congenital adrenal hyperplasia due to 21-OHD was retrospectively analyzed. In addition, potential mutations of the CYP21A2 gene was detected. RESULTS All patients were referred because of azoospermia or severe oligospermia and had small testis with averaged testicular volume of 6.1 mL. Three patients had testicular adrenal rest tumors. Endocrinologic examinations revealed low levels of leutinizing hormone and follicular stimulating hormone, normal or elevated testosterone, elevated progesterone, elevated or normal adrenocoticotropic hormone, and low or normal cortisol...
February 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29416565/a-report-of-nine-cases-and-review-of-the-literature-of-infertile-men-carrying-balanced-translocations-involving-chromosome-5
#4
REVIEW
Hong-Guo Zhang, Rui-Xue Wang, Yuan Pan, Han Zhang, Lei-Lei Li, Hai-Bo Zhu, Rui-Zhi Liu
Background: Balanced translocations may cause the loss of genetic material at the breakpoints and may result in failure of spermatogenesis. However, carriers of reciprocal translocation may naturally conceive. Genetic counseling of male carriers of translocations remains challenging. This study explores the clinical features of carriers of chromosome 5 translocations, enabling informed genetic counseling of these patients. Results: Of 82 translocation carriers, 9 (11%) were carriers of a chromosome 5 translocation...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29413225/microdissection-testicular-sperm-extraction-micro-tese-predictive-value-of-preoperative-hormonal-levels-and-pathology-in-non-obstructive-azoospermia
#5
Alper Eken, Feray Gulec
The aim of this study was to evaluate the predictive value of preoperative hormonal levels and pathology, as well as the outcome of microsurgical testicular sperm extraction in patients with non-obstructive azoospermia (NOA), presenting to our clinic for treatment of infertility. The records of 145 men with NOA who underwent microdissection testicular sperm extraction (micro-TESE) between March 2013 and November 2016 were studied. The patient's age, testicular volume, hormonal profile for follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (TT), and testicular pathology were recorded...
February 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29413092/a-single-dose-polyanhydride-based-vaccine-platform-promotes-and-maintains-anti-gnrh-antibody-titers
#6
Robert G Schaut, Matthew T Brewer, Jesse M Hostetter, Kriscelle Mendoza, Julia E Vela-Ramirez, Sean M Kelly, John K Jackman, Giuseppe Dell'Anna, Joan M Howard, Balaji Narasimhan, Wen Zhou, Douglas E Jones
Traditionally, vaccination strategies require an initial priming vaccination followed by an antigen boost to generate adequate immunity. Here we describe vaccination against a self-peptide for reproductive sterilization utilizing a three-stage vaccine platform consisting of gonadotropin releasing hormone multiple antigenic peptide (GnRH-MAP) as a soluble injection coupled with subcutaneous administration of polyanhydride-immobilized GnRH-MAP and a cyto-exclusive implant containing GnRH-MAP dendrimer-loaded polyanhydride...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29405167/current-status-of-sperm-banking-for-young-cancer-patients-in-japanese-nationwide-survey
#7
Yasushi Yumura, Akira Tsujimura, Hiroshi Okada, Kuniaki Ota, Masahumi Kitazawa, Tatsuya Suzuki, Tosiyuki Kakinuma, Seido Takae, Nao Suzuki, Teruaki Iwamoto
This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed the directors of 695 institutes where sperm cryopreservation might be performed with questionnaires requesting information on the number of patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, cryopreservation success rate, and causes of unsuccessful cryopreservation. Of these 695 institutes, 92 had cryopreserved sperm before chemotherapy within the study period...
February 2, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29404532/y-chromosome-microdeletions-frequency-in-idiopathic-azoospermia-oligoasthenozoospermia-and-oligospermia
#8
Delnya Gholami, Hamideh Jafari-Ghahfarokhi, Maryam Nemati-Dehkordi, Hossien Teimori
Background: Genetic factors are candidates for about 30% of male infertility with sperm production-related abnormalities. Y chromosome microdeletions are responsible for around 10% of male infertility. These microdeletions generally occur in azoospermia factor on the Yq. That is often associated with the quantitative reduction of sperm. Objective: The aim of this cross-sectional study was to determine the frequency of Yq microdeletions among idiopathic azoospermic, oligoasthenozoospermic, and oligospermic men in Shohada infertility center, Chaharmahal va Bakhtiari province...
November 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29398481/in%C3%A2-vitro-modeling-of-human-germ-cell-development-using-pluripotent-stem-cells
#9
Yuncheng Zhao, Shicheng Ye, Dongli Liang, Pengxiang Wang, Jing Fu, Qing Ma, Ruijiao Kong, Linghong Shi, Xueping Gong, Wei Chen, Wubin Ding, Wenjing Yang, Zijue Zhu, Huixing Chen, Xiaoxi Sun, Jun Zhu, Zheng Li, Yuan Wang
Due to differences across species, the mechanisms of cell fate decisions determined in mice cannot be readily extrapolated to humans. In this study, we developed a feeder- and xeno-free culture protocol that efficiently induced human pluripotent stem cells (iPSCs) into PLZF+/GPR125+/CD90+ spermatogonium-like cells (SLCs). These SLCs were enriched with key genes in germ cell development such as MVH, DAZL, GFRα1, NANOS3, and DMRT1. In addition, a small fraction of SLCs went through meiosis in vitro to develop into haploid cells...
February 13, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29382506/klinefelter-syndrome-more-than-hypogonadism
#10
REVIEW
George A Kanakis, Eberhard Nieschlag
Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1:650 newborn males), defined by 47,XXY karyotype. The classical phenotype is that of a tall male with relatively long legs, small, firm testes and gynecomastia. Azoospermia and infertility are almost inevitably present, but may be overcome by TESE and ICSI. Nevertheless, a broad spectrum of phenotypes has been described and >70% of the actually existing KS men may remain undiagnosed throughout their lifespan. Accordingly, hypogonadism is usually not evident until early adulthood and progresses with ageing...
January 27, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29373224/analysis-of-cdk2-mutations-in-chinese-men-with-non-obstructive-azoospermia-who-underwent-testis-biopsy
#11
Wen Liu, Xuan Gao, Lei Yan, Hongli Liu, Ruimei Yu, Shidou Zhao, Jinlong Ma
To examine whether mutations of the CDK2 gene exist in Chinese men with non-obstructive azoospermia (NOA) with different histopathology, we recruited 175 Chinese men with idiopathic NOA who underwent testis biopsy, including hypospermatogenesis, germ cell maturation arrest and Sertoli cell only syndrome. Genomic DNA was extracted from peripheral blood samples. Subsequently, the seven exons of the CDK2 gene were amplified using polymerase chain reaction with specific primers, respectively. The polymerase chain reaction products were sequenced on an automated sequencer...
January 4, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29371828/two-cases-of-reversible-male-infertility-due-to-congenital-adrenal-hyperplasia-combined-with-testicular-adrenal-rest-tumor
#12
Mikito Tanaka, Noritoshi Enatsu, Koji Chiba, Masato Fujisawa
Cases: Testicular adrenal rest tumor (TART) is one of the possible causes of male infertility, accompanied by congenital adrenal hyperplasia (CAH). Here are reported two cases of TARTs that were referred to Kobe City Medical Center West Hospital for the treatment of infertility and testicular tumors. Outcome: In one case, the semen analysis was improved from oligoasthenozoospermia to normozoospermia after taking oral glucocorticoid supplementation. The other case of original azoospermia showed that sperm had ejaculated into the semen after taking oral glucocorticoid supplementation...
January 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29371826/long-term-clinical-outcomes-of-testicular-sperm-extraction-and-intracytoplasmic-sperm-injection-for-infertile-men
#13
Noriyuki Okuyama, Ryuichiro Obata, Nao Oka, Yusuke Nakamura, Hiromitsu Hattori, Yukiko Nakajo, Nobuya Aono, Masae Koizumi, Mayumi Toya, Koichi Nagao, Toshihiro Tai, Tomoko Hashimoto, Hideki Igarashi, Koichi Kyono
Purpose: To find the best methods to achieve the highest pregnancy and birth rates for couples needing testicular sperm extraction (TESE)-intracytoplasmic sperm injection (ICSI). Methods: Retrospectively studied were 801 patients with male factor infertility who had undergone TESE-ICSI between April, 1996 and July, 2016 and who had been categorized into four groups: obstructive azoospermia (OA); non-obstructive azoospermia (NOA); Klinefelter syndrome (KS); and cryptozoospermia (Crypt)...
January 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29370621/re-prediction-model-for-obtaining-spermatozoa-with-testicular-sperm-extraction-in-men-with-non-obstructive-azoospermia
#14
Craig Niederberger
No abstract text is available yet for this article.
August 2017: Journal of Urology
https://www.readbyqxmd.com/read/29364721/usefulness-of-testicular-volume-apparent-diffusion-coefficient-and-normalized-apparent-diffusion-coefficient-in-the-mri-evaluation-of-infertile-men-with-azoospermia
#15
Byoung Hee Han, Sung Bin Park, Ju Tae Seo, Yi Kyeong Chun
OBJECTIVE: The purpose of this article is to assess retrospectively the usefulness of testicular volume, apparent diffusion coefficient (ADC), and normalized ADC as measured using MRI in predicting the histopathologic grade of azoospermia and in differentiating obstructive from nonobstructive azoospermia. MATERIALS AND METHODS: A computerized search generated a list of 30 infertile men with azoospermia who had undergone both scrotal MRI and testis biopsy. MRI-determined testicular volumes, ADCs, and normalized ADCs were compared between infertile men with obstructive azoospermia and those with nonobstructive azoospermia...
January 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29354302/application-of-stereological-methods-for-unbiased-estimation-of-sperm-morphology-in-the-mice-induced-by-busulfan
#16
Sakineh Panahi, Mohammad-Amin Abdollahifar, Abbas Aliaghaei, Hamid Nazarian, Shahrokh Paktinat, Shabnam Abdi, Reza Mastery Farahani
Busulfan is an anticancer drug, which causes the apoptosis germ cells and azoospermia in humans and animals. Abnormal morphology of spermatozoa related to the male infertility. The sperm morphology is evaluation of sperm size, shape and appearance characteristics should be assessed by carefully observing a stained sperm sample under the microscope. Evaluation of sperm morphology has been considered as one of the most important factors for a successful fertilization and determining sperm quality. The mice were assigned to tow experimental groups: control and busulfan...
December 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29343909/decline-in-semen-parameters-from-2000-to-2016-among-bangladeshi-men-attending-a-tertiary-care-hospital
#17
Nusrat Mahmud, Eshita Sharmin, Md Arif Mamun, Zayan Shamayeen, Natalie Rivadeneira, Roger Rochat, Akanksha Mehta
Introduction: The objective of this study was to analyze longitudinal changes in sperm parameters of Bangladeshi men. We hypothesized that semen parameters declined for this population. Methods: We retrospectively analyzed semen data from men aged 18-64 years who sought care for general sperm quality or updates on fertility status at an infertility clinic in Dhaka, Bangladesh, from January 2000 to June 2016 (n = 13,953). Samples with incomplete data were excluded (n = 143)...
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29335009/isolated-follicle-stimulated-hormone-deficiency-in-male-case-report
#18
Gowri M Ratnayake, P N Weerathunga, L P Ruwanpura, Amila Wickramasinghe, Prasad Katulanda
BACKGROUND: Recent rapid advances in assisted reproductive health technologies enables couples with subfertility to conceive through various intervention. Majority of treatment modalities target the female partner. However it is important to identify and treat male factor subfertility right at the outset. We report a case of isolated follicle stimulating hormone deficiency resulting in azoospermia and primary subfertility. CASE PRESENTATION: A 28 year otherwise healthy male presented with primary subfertility with a healthy female counterpart...
January 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29331980/dmc1-mutation-that-causes-human-non-obstructive-azoospermia-and-premature-ovarian-insufficiency-identified-by-whole-exome-sequencing
#19
Wen-Bin He, Chao-Feng Tu, Qiang Liu, Lan-Lan Meng, Shi-Min Yuan, Ai-Xiang Luo, Fu-Sheng He, Juan Shen, Wen Li, Juan Du, Chang-Gao Zhong, Guang-Xiu Lu, Ge Lin, Li-Qing Fan, Yue-Qiu Tan
BACKGROUND: The genetic causes of the majority of male and female infertility caused by human non-obstructive azoospermia (NOA) and premature ovarian insufficiency (POI) with meiotic arrest are unknown. OBJECTIVE: To identify the genetic cause of NOA and POI in two affected members from a consanguineous Chinese family. METHODS: We performed whole-exome sequencing of DNA from both affected patients. The identified candidate causative gene was further verified by Sanger sequencing for pedigree analysis in this family...
January 13, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29330018/testicular-adrenal-rest-tumor-screening-and-fertility-counseling-among-males-with-congenital-adrenal-hyperplasia
#20
Monika Chaudhari, Emilie K Johnson, Daniel DaJusta, Leena Nahata
BACKGROUND: Reduced fertility is a common potential problem among males with congenital adrenal hyperplasia (CAH), with nearly half experiencing impaired sperm production. The major cause of oligo/azoospermia in CAH is testicular adrenal rest tumors (TARTs). Studies indicate that ultrasound screening for TARTs should begin during childhood, yet it remains unclear whether boys with CAH are routinely screened for TARTs and/or counseled about infertility risk and potential interventions such as fertility testing and/or preservation...
December 21, 2017: Journal of Pediatric Urology
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