keyword
https://read.qxmd.com/read/37732066/a-study-of-the-proteomic-expression-in-patients-with-complicated-parapneumonic-pleural-effusion
#21
JOURNAL ARTICLE
Xin Wu, Wei Yang, Xiao-Hua Gou, Xiao-Yun Xu, Na Lu, Shi-Ning Jian, Yu-Jie Han, Tong-Shuai Lv, Li-Zhu Luo
INTRODUCTION: The present study aimed to investigate the differences in the proteomic expression between uncomplicated parapneumonic pleural effusion (UPPE) and complicated parapneumonic pleural effusion (CPPE). MATERIAL AND METHODS: There were 10 patients with UPPE and 10 patients with CPPE. These patients were combined due to the complication of pleural effusion and further divided into group A and group B. An LC-MS analysis was conducted with the extraction of high-abundance proteins, and proteins with 1...
2023: Archives of Medical Science: AMS
https://read.qxmd.com/read/37730573/analysis-of-clinical-characteristics-and-risk-factors-of-community-acquired-pneumonia-complicated-by-parapneumonic-pleural-effusion-in-elderly-patients
#22
JOURNAL ARTICLE
Mingmei Zhong, Ruiqin Ni, Huizhen Zhang, Yangyang Sun
BACKGROUND: Community-acquired pneumonia (CAP) patients usually present with parapneumonic pleural effusion (PPE), which complicates the treatment of pneumonia. This study aims to investigate the clinical characteristics and risk factors of elderly CAP patients hospitalised with PPE. METHODS: The clinical data of 132 elderly patients with CAP were retrospectively analysed. A total of 54 patients with PPE (PPE group) and 78 patients without PPE (NPPE group) were included in this study...
September 20, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/37726943/diagnostic-accuracy-of-lactate-dehydrogenase-adenosine-deaminase-ratio-in-differentiating-tuberculous-and-parapneumonic-effusions-a-systematic-review
#23
JOURNAL ARTICLE
Larry Ellee Nyanti, Muhammad Aklil Abd Rahim, Nai-Chien Huan
BACKGROUND: Tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) are often difficult to differentiate owing to the overlapping clinical features. Observational studies demonstrate that the ratio of lactate dehydrogenase to adenosine deaminase (LDH/ADA) is lower in TPE compared to PPE, but integrated analysis is warranted. METHODS: We conducted a systematic review to evaluate the diagnostic accuracy of the LDH/ADA ratio in differentiating TPE and PPE...
January 2024: Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/37709682/intrapleural-thrombolytics-as-first-line-therapy-for-complicated-parapneumonic-effusions-and-empyema-in-patients-with-prohibitive-surgical-risk-a-cases-series
#24
JOURNAL ARTICLE
Sulimar Morales-Colón, Mariela M Rivera-Agosto, Mariana Mercader-Pérez, Onix Cantres-Contreras, William Rodríguez-Cintrón
OBJECTIVE: In complicated parapneumonic effusion or Empyema, approximately 25% of patients require surgical intervention which can be associated with a mortality risk of almost 20%. However, the use combination of rt-tPA and DNase in elderly patients with prohibitive surgical risk has improved outcomes. The main goal of our study is to highlight the utility of intrapleural thrombolysis in patients with prohibitive risk for surgery. METHODS: A retrospective record review study of patients (n=23) with complicated parapneumonic pleural effusion or empyema treated with tPA and DNase from January 1st of 2015 to March 18th, 2019 at VACHCS...
September 2023: Puerto Rico Health Sciences Journal
https://read.qxmd.com/read/37663038/diagnostic-yield-of-16s-ribosomal-ribonucleic-acid-gene-based-targeted-metagenomic-sequencing-for-evaluation-of-pleural-space-infection-a-prospective-study
#25
JOURNAL ARTICLE
Luis Gimenez-Miranda, Bilal F Samhouri, Matthew J Wolf, Dagny K Anderson, David E Midthun, Kaiser G Lim, Ryan M Kern, Robin Patel, Eva M Carmona
OBJECTIVE: To better understand the microbial profile of complicated parapneumonic effusions and empyema, and to evaluate whether antimicrobial selection would differ if guided by targeted metagenomic sequencing (tMGS) vs conventional cultures (CCs) alone. PATIENTS AND METHODS: We analyzed the pleural fluid of a cohort of 47 patients undergoing thoracentesis from January 1, 2017 to August 31, 2019, to characterize their microbial profile. All samples underwent 16S ribosomal ribonucleic acid gene polymerase chain reaction, followed by tMGS...
October 2023: Mayo Clinic Proceedings. Innovations, Quality & Outcomes
https://read.qxmd.com/read/37660939/the-diagnostic-value-of-interleukin-36-cytokines-in-pleural-effusions-of-varying-etiologies
#26
JOURNAL ARTICLE
Xuxiang Song, Lun Guo, Qipan Zhang, Weili Chen, Wei Fan, Chengna Lv, Pan Tang, Zhaoxing Dong, Xudeng Ye, Qunli Ding
BACKGROUND: The clinical management of pleural effusion (PE) poses challenges due to its diverse etiologies. The objective of this research was to investigate the concentrations of interleukin-36 (IL-36) cytokines in pleural fluid (PF) from different etiologies and assess their diagnostic efficacy in distinguishing the causes of PE. METHODS: This study enrolled 89 patients with confirmed PE, comprising 11 cases classified as transudate, 24 cases as malignant pleural effusion (MPE), 24 cases as tuberculous pleural effusion (TPE), and 30 cases as parapneumonic pleural effusion (PPE)...
September 1, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/37637529/unraveling-a-unique-encounter-of-fusobacterium-nucleatum-with-empyema-a-case-report-and-review-of-literature
#27
Raghavendra R Sanivarapu, Ramya Sruthi Rajamreddy, Ateet Kosaraju
We report a case of Fusobacterium nucleatum  ( F. nucleatum )   empyema in a 34-year-old male with no significant past medical history or obvious risk factors who presented with shortness of breath and chest pain. His imaging showed complicated parapneumonic effusion which grew  F. nucleatum. He was started on piperacillin-tazobactam. The patient's clinical condition deteriorated despite initial therapeutic efforts, leading to escalated antibiotic therapy and further investigations. The patient's subsequent clinical course included pigtail catheter placement with drainage of fluid requiring tpa and dornase alpha, leading to significant improvement and eventual discharge on oral amoxicillin-clavulanic acid...
July 2023: Curēus
https://read.qxmd.com/read/37607215/the-mtorc2-sgk1-ndrg1-signaling-axis-is-critical-for-mesomesenchymal-transition-of-pleural-mesothelial-cells-and-the-progression-of-pleural-fibrosis
#28
JOURNAL ARTICLE
Shiva Keshava, Shuzi Owens, Wenyi Qin, Ann Jeffers, Perpetual Kyei, Satoshi Komatsu, Joshua Kleam, Mitsuo Ikebe, Steven Idell, Torry A Tucker
Progressive lung scarring due to persistent pleural organization often results in pleural fibrosis (PF). This process affects patients with complicated parapneumonic pleural effusions, empyema, and other pleural diseases prone to loculation. In PF, pleural mesothelial cells undergo mesomesenchymal transition (MesoMT) to become profibrotic, characterized by increased expression of α-smooth muscle actin (α-SMA) and matrix proteins, including collagen (Col)-1. In our previous study, we showed that blocking PI3K/Akt signaling inhibits MesoMT induction in human pleural mesothelial cells (HPMCs)...
August 22, 2023: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/37581374/clinical-significance-of-pleural-lactate-measurement-in-critically-ill-patients-with-parapneumonic-pleural-effusion
#29
JOURNAL ARTICLE
Bişar Ergün, Murat Küçük, Mehmet Nuri Yakar, Mehmet Celal Öztürk, Vecihe Bayrak, Ahmet Naci Emecen, Volkan Hancı, Bilgin Cömert, Ali Necati Gökmen, Begüm Ergan
OBJECTIVE: Pleural fluid pH measurement is recommended for tube thoracostomy decisions in complicated parapneumonic pleural effusions. However, pleural fluid pH may be affected by blood pH in critically ill patients with common systemic acid-base disorders. We aimed to investigate the use of pleural fluid lactate to distinguish culture-positive parapneumonic effusions from other pleural effusions. MATERIAL AND METHODS: This prospective observational study included 121 eligible patients (51 female and 70 male)...
August 15, 2023: Thorac Res Pract
https://read.qxmd.com/read/37566896/current-management-of-pediatric-parapneumonic-pleural-effusions-and-pleural-empyema
#30
JOURNAL ARTICLE
Johannes Forster, Pia Paul, Johannes Liese
No abstract text is available yet for this article.
August 2, 2023: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/37554852/percutaneous-management-of-complicated-empyema-thoracis-using-pigtail-report-of-a-case-from-university-hospital-of-nepal-a-case-report
#31
JOURNAL ARTICLE
Sumina Mainali, Binay Yadav, Naman Koju, Aashish Karki, Narendra K C, Dhanupa Bista
UNLABELLED: Empyema thoracis is a condition characterized by the accumulation of pus in the pleural cavity of the lungs. Empyema thoracis is a cause of high mortality in man and its occurrence is increasing in both children and adults. Traditionally, chest tube drainage has been a preferred method of treatment, but recent studies have shown that pigtail catheter drainage is a more effective and less invasive alternative. Image-guided drainage is also preferred over blind drainage, and alternative drainage sites are being explored...
August 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37429296/expert-review-on-nonsurgical-management-of-parapneumonic-effusion-advances-controversies-and-new-directions
#32
MULTICENTER STUDY
Deirdre B Fitzgerald, Eva Polverino, Grant W Waterer
Parapneumonic effusion and empyema are rising in incidence worldwide, particularly in association with comorbidities in an aging population. Also driving this change is the widespread uptake of pneumococcal vaccines, leading to the emergence of nonvaccine-type pneumococci and other bacteria. Early treatment with systemic antibiotics is essential but should be guided by local microbial guidelines and antimicrobial resistance patterns due to significant geographical variation. Thoracic ultrasound has emerged as a leading imaging technique in parapneumonic effusion, enabling physicians to characterize effusions, assess the underlying parenchyma, and safely guide pleural procedures...
August 2023: Seminars in Respiratory and Critical Care Medicine
https://read.qxmd.com/read/37332399/a-possible-association-between-covid-19-vaccine-and-complicated-pleural-effusion-a-case-report
#33
Bashar Oudah, Mohammad Abu-Abaa, Noor Al-Ameri, Jonathan Ghazaleh, Vijay Vanam
As COVID-19 vaccines gain more prevalence, previously unrecognized side effects continue to be reported. We report a case of 78 male with no significant past medical history who was found to have a unilateral pleural effusion with symptoms that started two days after the administration of a COVID-19 vaccine. The initial presumption was bacterial pneumonia with parapneumonic effusion. However, the lack of clinical response prompted surgical intervention, and a diagnosis of empyema was established. No evidence of infectious etiology was found...
May 2023: Curēus
https://read.qxmd.com/read/37324069/differentiating-between-tuberculous-and-non-tuberculous-pleural-effusions-using-the-pleural-fluid-ratio-of-10%C3%A3-adenosine-deaminase-lactate-dehydrogenase
#34
JOURNAL ARTICLE
Yan Li, Zhujun Chen, Pan Yang, Hailing Duan, Jian He, Liang Gong, Lintao Zhao
BACKGROUND: Adenosine deaminase (ADA) is a sensitive marker of tuberculous pleural effusion (TBPE). However, in pleural effusion (PE), the detection of ADA alone cannot be used to determine whether the increase in the ADA level is caused by the rising proportion of macrophages and lymphocytes in the cell components or by the increase in the total cell number. The diagnostic precision of ADA is probably restricted due to the false positive and negative results. Thus, we explored the clinical value of the ratio of PE ADA to lactate dehydrogenase (LDH) in differentiating between TBPE and non-TBPE...
May 30, 2023: Journal of Thoracic Disease
https://read.qxmd.com/read/37187631/streptococcus-anginosus-lung-abscess-with-complicated-parapneumonic-empyema
#35
Laura M Gonzalez, Lutfor Nessa, Raghavendra Sanivarapu, Barath Rangaswamy, Laura Rojo
A 55-year-old female with hypertension presented to our facility with complicated pneumonia. She complained of progressively worsening shortness of breath and pleuritic chest pain. She was in her usual state of health except for an upper respiratory infection treated with oral antibiotics a month prior. At the presentation, she was febrile, tachycardic, and hypoxic on room air. A chest computed tomography (CT) showed near-complete opacification of the right lung, a cavitation with the fluid level in the right middle lobe, and moderate-to-large effusion...
April 2023: Curēus
https://read.qxmd.com/read/37150161/necrotizing-fasciitis-of-the-chest-wall-caused-by-empyema-necessitans-following-tuberculosis-case-report-and-literature-review
#36
Nebiyou Bayileyegn, Dawit Teka Mengiste
INTRODUCTION AND IMPORTANCE: Empyema is a serious complication characterized by pus and bacteria in the pleural space which may progress to necrosis, cavitation, or fistulas in the thoracic cavity. Infection and trauma are the commonest causes in the developed countries while tuberculosis is the commonest cause of empyema in developing countries. Empyema necessitans is a rare complication of pleural space infections. CASE PRESENTATION: A 50 years old male patient presented to our hospital with right side chest pain and shortness of breath of 3-week duration...
May 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37147024/parapneumonic-effusions-related-to-streptococcus-pneumoniae-serotype-and-disease-severity-trends-from-2006-to-2018-in-bristol-uk
#37
JOURNAL ARTICLE
Catherine Hyams, David T Arnold, Robyn Heath, Zahin Amin-Chowdhury, David Hettle, Gabriella Ruffino, Paul North, Charli Grimes, Norman K Fry, Philip Williams, Robert Challen, Leon Danon, O Martin Williams, Shamez Ladhani, Adam Finn, Nick Maskell
RATIONALE: Streptococcus pneumoniae epidemiology is changing in response to vaccination and some data suggest that empyema incidence is increasing. However, differences exist between the UK and US studies. We describe trends in the clinical phenotype of adult pneumococcal pleural infection, including simple parapneumonic effusions (SPE) in the pneumococcal conjugate vaccination (PCV) era. OBJECTIVES: To determine whether there were differences in pneumococcal disease presentation and severity associated with pleural infection...
May 2023: BMJ Open Respiratory Research
https://read.qxmd.com/read/37029951/intrapleural-tissue-plasminogen-activator-and-deoxyribonuclease-administered-concurrently-and-once-daily-for-complex-parapneumonic-pleural-effusion-and-empyema
#38
JOURNAL ARTICLE
Dugal Smith, Hannah Shaw, Timothy Ryder
BACKGROUND: Pleural infection is life-threatening and increasingly prevalent. In addition to usual care, twice-daily, separate administration of tissue plasminogen activator and deoxyribonuclease (tPA-DNase) reduces radiological pleural opacity with lower surgical referral rates. AIMS: This retrospective cohort study examines the use of once-daily, concurrent administration of tPA-DNase for complex parapneumonic pleural effusion and empyema. METHODS: Patients with pleural infection who received intrapleural tPA-DNase between October 2014 and July 2020 at Logan Hospital, where it is given concurrently and once-daily as salvage therapy, were retrospectively identified...
April 8, 2023: Internal Medicine Journal
https://read.qxmd.com/read/37021765/measurement-of-lactate-in-pleural-fluid-rapidly-identify-infection-and-guide-therapy
#39
JOURNAL ARTICLE
Niclas Johansson, Karin Andersson Ydsten, Carolina Backman-Johansson, Martin Vondracek, Jonas Hedlund
BACKGROUND: Measurements of pleural fluid biomarkers for rapid identification of complicated parapneumonic effusion (CPPE) are crucial for optimal management. Previous studies for biomarker evaluation were however based on pleura culture, not modern DNA technique. Lactate has not been thoroughly studied earlier as a potential biomarker in this regard. OBJECTIVES: To evaluate whether the routine biomarkers pH, glucose, lactate dehydrogenase (LDH) measured in pleural fluid in a microbiological well characterised cohort could differentiate simple parapneumonic effusion (SPPE) from CPPE and if pleural fluid lactate could be of additional use in this discrimination...
June 2023: Infectious Diseases
https://read.qxmd.com/read/36946411/parapneumonic-effusion-in-children-rapid-pathogen-detection-in-pleural-fluid-using-multiplex-bacterial-pcr
#40
JOURNAL ARTICLE
Ulrikka Nygaard, Nikolai Søren Kirkby, Joakim Bloch, Naqash Javaid Sethi, Alex Christian Yde Nielsen, Anja Poulsen, Frederik Buchvald, Marie-Louise von Linstow, Nadja Hawwa Vissing
No abstract text is available yet for this article.
July 2023: Acta Paediatrica
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