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https://www.readbyqxmd.com/read/28721849/effective-protection-of-mice-against-shigella-flexneri-with-a-new-self-adjuvant-multicomponent-vaccine
#1
Yadira Pastor, Ana Camacho, Ana Gloria Gil, Rocío Ramos, Adela López de Ceráin, Iván Peñuelas, Juan M Irache, Carlos Gamazo
PURPOSE: The aim of this study was to develop an immunogenic protective product against Shigella flexneri by employing a simple and safe heat treatment-based strategy. METHODOLOGY: The physicochemical characteristics of naturally produced (OMV) and heat-induced (HT) outer-membrane vesicles from S. flexneri were examined, including a comparison of the protein content of the products. Toxicological and biodistribution studies, and a preliminary experiment to examine the protective effectiveness of HT in a murine model of S...
July 18, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28720951/isolation-and-characterization-of-lactic-acid-bacteria-from-traditional-pickles-of-himachal-pradesh-india
#2
Monika, Savitri, Vijay Kumar, Anila Kumari, Kunzes Angmo, Tek Chand Bhalla
A total of 15 isolates of lactic acid bacteria (LAB) were isolated from traditional pickles of rural and urban areas of Himachal Pradesh. These isolates were identified as Enterococcus faecalis (7), Lactobacillus plantarum (3), Pediococcus pentosaceus (2), Leuconostoc mesenteroides (1), Lactococcus lactis (1) and Enterococcus sp. (1) on the basis of morphological, biochemical and 16S rDNA sequence analysis. All the LABs produced exopolysaccharides, have antibiotic susceptibility, and possess activity of β-galactosidase, β-glucosidase, protease and amylase, while none of the isolates showed haemolytic activity...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28716138/prevalence-of-enteric-infections-among-hospitalized-patients-in-two-referral-hospitals-in-ghana
#3
R Akuffo, G Armah, M Clemens, K C Kronmann, A H Jones, P Agbenohevi, K Sagoe, N Puplampu, N Talla Nzussouo, W Ampofo, K Koram, C Duplessis, E Dueger
BACKGROUND: Diarrhea is an important cause of morbidity and mortality worldwide. In Africa and Ghana in particular, it is estimated to contribute directly to 19 and 25% of pediatric mortality among children under 5 years, respectively. METHODS: Surveillance for hospitalized acute diarrheal illness was initiated in November 2010 through October 2012 in a referral hospital in southern Ghana, and a teaching hospital in northern Ghana. Consenting hospitalized patients who met a standardized case definition for acute diarrheal illness provided demographic and epidemiologic data...
July 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28713514/detection-of-eight-foodborne-bacterial-pathogens-by-oligonucleotide-array-hybridization
#4
Zohreh Nasrabadi, Reza Ranjbar, Fatemeh Poorali, Meysam Sarshar
BACKGROUND: Simultaneous and rapid detection of multiple foodborne bacterial pathogens is important for the prevention of foodborne illnesses. OBJECTIVE: The aim of this study was to evaluate the use of 16S rDNA and 23S rDNA sequences as targets for simultaneous detection of eight foodborne bacterial pathogens. METHODS: Nineteen bacterial oligonucleotide probes were synthesized and applied to nylon membranes. Digoxygenin labeled 16S rDNA and 23S rDNA from bacteria were amplified by PCR using universal primers, and the amplicons were hybridized to the membrane array...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28711269/development-of-an-isothermal-amplification-based-assay-for-the-rapid-visual-detection-of-salmonella-bacteria
#5
Hai-Bin Liu, Yu-Xuan Zang, Xin-Jun Du, Ping Li, Shuo Wang
The efficient and timely detection of pathogens is a major concern worldwide. The aim of this study was to establish a rapid detection method for Salmonella bacteria in food samples to facilitate timely treatment. Widely used detection methods currently include culture-based methods and PCR-based methods. The former are time consuming, requiring 2 to 3 d, whereas the latter have higher accuracy but are typically complicated, requiring expertise and expensive instruments. In this study, a sensitive and rapid approach for the visual and point-of-use detection of Salmonella bacteria based on recombinase polymerase amplification (RPA) and a lateral-flow (LF) nucleic acid strip was established...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28705515/combination-vaccine-strategies-to-prevent-enteric-infections
#6
Richard Walker, Peter Dull
New vaccine candidates entering the current routine immunization schedule can best be accommodated as combination vaccines. A combined Shigella and enterotoxigenic E. coli (ETEC) vaccine could greatly benefit children in disease-endemic areas. New candidates are getting closer to being able to meet these needs, but they raise numerous strategic questions related to presentation, formulation, and regulatory approach. The "Combination Vaccine Strategies to Prevent Enteric Infections" workshop at the 2016 Vaccines Against Shigella and ETEC (VASE) Conference examined some of the considerations for developing such vaccines against enteric pathogens...
July 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28701483/the-shigella-type-iii-effector-ipgd-recodes-ca-2-signals-during-invasion-of-epithelial-cells
#7
Chun Hui Sun, Benjamin Wacquier, Daniel I Aguilar, Nathalie Carayol, Kevin Denis, Sylviane Boucherie, Cesar Valencia-Gallardo, Ceren Simsek, Christophe Erneux, Alexandre Lehman, Jost Enninga, Laurence Arbibe, Philippe Sansonetti, Geneviève Dupont, Laurent Combettes, Guy Tran Van Nhieu
The role of second messengers in the diversion of cellular processes by pathogens remains poorly studied despite their importance. Among these, Ca(2+) virtually regulates all known cell processes, including cytoskeletal reorganization, inflammation, or cell death pathways. Under physiological conditions, cytosolic Ca(2+) increases are transient and oscillatory, defining the so-called Ca(2+) code that links cell responses to specific Ca(2+) oscillatory patterns. During cell invasion, Shigella induces atypical local and global Ca(2+) signals...
July 12, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28694104/antimicrobial-natural-product-research-a-review-from-a-south-african-perspective-for-the-years-2009-2016
#8
REVIEW
S Van Vuuren, D Holl
ETHNOPHARMACOLOGICAL RELEVANCE: This review provides information on the antimicrobial research which has taken place on South African natural products for the last eight years (2009-2016). This important field is the backbone of all studies involving the use of medicinal plants against infectious diseases and hence can form the mainstay for future studies. MATERIALS AND METHODS: All publications within the years 2009-2016 were considered. Exclusion criteria were studies not involving South African medicinal natural products and those publications where full articles could not be accessed...
July 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28690880/the-prevalence-of-ctx-m-15-extended-spectrum-%C3%AE-lactamases-among-salmonella-spp-and-shigella-spp-isolated-from-three-iranian-hospitals
#9
Abed Zahedi Bialvaei, Tala Pourlak, Mina Aghamali, Mohammad Asgharzadeh, Pourya Gholizadeh, Hossein Samadi Kafil
Bacterial antimicrobial resistance mediated by the production of extended-spectrum β-lactamases (ESBLs) is considered a major threat for treatment of Salmonella and Shigella infections. This study aimed to investigate antibiotic resistance patterns of Salmonella and Shigella spp. and presence of CTX-M from three teaching hospitals in Iran. In the present study, 58 clinical Shigella and 91 Salmonella isolates were recovered between 2009 and 2013 from 3 teaching hospitals in Iran. After culture and antimicrobial susceptibility testing, ESBL-positive isolates were subjected to further investigations...
June 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28689895/plasmid-mediated-transfer-of-ctx-m-55-extended-spectrum-beta-lactamase-among-different-strains-of-salmonella-and-shigella-spp-in-the-republic-of-korea
#10
Jin Seok Kim, Soojin Kim, Jungsun Park, Eunkyung Shin, Young-Sun Yun, Deog-Yong Lee, Hyo-Sun Kwak, Won Keun Seong, Gyung Tae Chung, Junyoung Kim
We screened 10 CTX-M-55-producing Shigella and Salmonella isolates from a national surveillance in Korea. The blaCTX-M-55 was located on the IncI1 (n=5), IncA/C (n=4) and IncZ (n=1) plasmids, downstream of ISEcp1, IS26-ISEcp1 and ISEcp1-IS5 sequences, respectively. These results indicate that CTX-M-55 has disseminated to other bacteria by lateral plasmid transfer.
March 30, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28683780/bacterial-agents-and-antibiotic-resistance-profiles-of-infections-from-different-sites-that-occurred-among-patients-at-debre-markos-referral-hospital-ethiopia-a-cross-sectional-study
#11
Wondemagegn Mulu, Bayeh Abera, Mulat Yimer, Tadesse Hailu, Haimanot Ayele, Dereje Abate
BACKGROUND: In developing countries like Ethiopia, infections with antibiotic resistant bacteria become a real threat. Hence, monitoring of local level antimicrobial resistance profile is indispensable to contain the spread of drug resistant bacteria and intervene poor awareness on antimicrobial resistance. Therefore, this study aimed at determining bacterial and antibiotic resistance profiles of infections from different sites that occurred among patients. METHODS: Retrospective data recorded were analyzed on culture and drug susceptibility test results at Debre Markos Referral Hospital which were performed from 2011 to 2014...
July 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28674052/characterization-of-a-large-antibiotic-resistance-plasmid-found-in-enteropathogenic-escherichia-coli-strain-b171-and-its-relatedness-to-plasmids-of-diverse-e-coli-and-shigella
#12
Tracy H Hazen, Jane Michalski, Sushma Nagaraj, Iruka N Okeke, David A Rasko
Enteropathogenic Escherichia coli (EPEC) are a leading cause of severe infantile diarrhea in developing countries. Previous research has focused on the diversity of the EPEC virulence plasmid, whereas less is known regarding the genetic content and distribution of antibiotic resistance plasmids carried by EPEC. A previous study demonstrated that in addition to the virulence plasmid, reference EPEC strain B171 harbors a second, larger plasmid that confers antibiotic resistance. To further understand the genetic diversity and dissemination of antibiotic resistance plasmids among EPEC, we describe the complete sequence of an antibiotic resistance plasmid from EPEC strain B171...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28665628/incidence-of-shigella-intestinal-infections-active-component-u-s-armed-forces-2007-2016
#13
Valerie F Williams, Shauna Stahlman, Gi-Taik Oh
During 2007-2016, there were 428 incident cases of Shigella infection among active component service members, with an overall crude incidence rate of 3.4 cases per 100,000 person-years (p-yrs). Compared to their respective counterparts, overall incidence rates were highest among females, non-Hispanic black service members, those aged 35-39 years, members of the Army, and those in military healthcare occupations. With the exception of 2015, the annual incidence rates of shigellosis from 2007 through 2016 were relatively stable...
June 2017: MSMR
https://www.readbyqxmd.com/read/28664152/type-iii-secretion-in-the-melioidosis-pathogen-burkholderia-pseudomallei
#14
REVIEW
Charles W Vander Broek, Joanne M Stevens
Burkholderia pseudomallei is a Gram-negative intracellular pathogen and the causative agent of melioidosis, a severe disease of both humans and animals. Melioidosis is an emerging disease which is predicted to be vastly under-reported. Type III Secretion Systems (T3SSs) are critical virulence factors in Gram negative pathogens of plants and animals. The genome of B. pseudomallei encodes three T3SSs. T3SS-1 and -2, of which little is known, are homologous to Hrp2 secretion systems of the plant pathogens Ralstonia and Xanthomonas...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28663747/polychlorinated-biphenyl-pcb-degrading-potential-of-microbes-present-in-a-cryoconite-of-jamtalferner-glacier
#15
Nancy Weiland-Bräuer, Martin A Fischer, Karl-Werner Schramm, Ruth A Schmitz
Aiming to comprehensively survey the potential pollution of an alpine cryoconite (Jamtalferner glacier, Austria), and its bacterial community structure along with its biodegrading potential, first chemical analyses of persistent organic pollutants, explicitly polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) as well as polycyclic aromatic hydrocarbons (PAHs), revealed a significant contamination. In total, 18 PCB congeners were detected by high resolution gas chromatography/mass spectrometry with a mean concentration of 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28658760/shigella-sonnei-sepsis-in-an-infant-a-case-report
#16
Charu Nayyar, Preeti Thakur, Vibhor Tak, Amitabh Singh
Shigella bacteraemia is a complication of gastroenteritis caused by Shigella spp. which occurs mainly in immunocompromised children. Other risk factors may include young malnourished children, patients with chronic disease, post transplant patients etc. We present a case of six-month-old infant who developed an episode of gastroenteritis caused by Shigella sonnei which was followed by septicaemia. The patient was managed well and he recovered. Shigella sonnei was isolated in both stool as well as blood culture...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658607/phylogenomics-and-comparative-genomic-studies-delineate-six-main-clades-within-the-family-enterobacteriaceae-and-support-the-reclassification-of-several-polyphyletic-members-of-the-family
#17
Seema Alnajar, Radhey S Gupta
The family Enterobacteriaceae harbors many important pathogens, however it has proven difficult to reliably distinguish different members of this family or discern their interrelationships. To understand the interrelationships among the Enterobacteriaceae species, we have constructed two comprehensive phylogenetic trees for 78 genome-sequenced Enterobacteriaceae species based on 2487 core genome proteins, and another set of 118 conserved proteins. The genome sequences of Enterobacteriaceae species were also analyzed for genetic relatedness based on average amino acid identity and 16S rRNA sequence similarity...
June 26, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28656051/evaluating-the-timeliness-of-enteric-disease-surveillance-in-british-columbia-canada-2012-13
#18
Eleni Galanis, Marsha Taylor, Kamila Romanowski, Olga Bitzikos, Jennifer Jeyes, Craig Nowakowski, Jason Stone, Michelle Murti, Ana Paccagnella, Sara Forsting, Sophie Li, Linda Hoang
Timely surveillance of enteric diseases is necessary to identify and control cases and outbreaks. Our objective was to evaluate the timeliness of enteric disease surveillance in British Columbia, Canada, compare these results to other settings, and recommend improvements. In 2012 and 2013, information was collected from case report forms and laboratory information systems on 2615 Salmonella, shigatoxin-producing E. coli, Shigella, and Listeria infections. Twelve date variables representing the surveillance process from onset of symptoms to case interview and final laboratory results were collected, and intervals were measured...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28654862/biopolymer-zein-coated-gold-nanoparticles-synthesis-antibacterial-potential-toxicity-and-histopathological-effects-against-the-zika-virus-vector-aedes-aegypti
#19
Periyakaruppan Suganya, Baskaralingam Vaseeharan, Sekar Vijayakumar, Banumathi Balan, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
The control of multidrug-resistant bacteria as well as insect pests and vectors is timely and important now a days. The present study was designed to evaluate the in vitro antibacterial, antibiofilm and mosquito larvicidal effects of gold nanoparticles synthesized using the zein biopolymer (Ze-AuNPs) against Gram positive (Bacillus pumilus and Bacillus subtilis), Gram negative (Shigella sonnei and Pseudomonas aeruginosa) bacteria and third instar larvae of the dengue and Zika virus vector Aedes aegypti. The synthesized Ze-AuNPs were characterized by UV-vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM)...
June 17, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28652301/stand-alone-eal-domain-proteins-form-a-distinct-subclass-of-eal-proteins-involved-in-regulation-of-cell-motility-and-biofilm-formation-in-enterobacteria
#20
Youssef El Mouali, Hyunhee Kim, Irfan Ahmad, Annelie Brauner, Ying Liu, Mikael Skurnik, Michael Y Galperin, Ute Römling
The second messenger cyclic di-GMP is almost ubiquitous among bacteria and so are the cyclic di-GMP turnover proteins, which mediate the transition between motility and sessility. EAL domain proteins have been characterized as cyclic di-GMP-specific phosphodiesterases. While most EAL domain proteins contain additional, usually N-terminal, domains, there is a distinct family of proteins within stand-alone EAL domains, exemplified by Salmonella enterica serovar Typhimurium proteins STM3611 (YhjH/PdeH), a c-di-GMP-specific phosphodiesterase, and the enzymatically inactive STM1344 (YdiV/CdgR) and STM1697, which regulate bacterial motility through interaction with the flagella master regulator FlhDC...
June 26, 2017: Journal of Bacteriology
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