keyword
https://read.qxmd.com/read/36622274/relative-bioavailability-and-food-effect-of-asciminib-pediatric-mini-tablet-formulation-compared-to-the-reference-tablet-formulation-in-healthy-adult-participants
#21
JOURNAL ARTICLE
Matthias Hoch, Lidiya Bebrevska, Namrata Singh, Florence Hourcade-Potelleret
Asciminib, a first-in-class allosteric BCR::ABL1 inhibitor that works by Specifically Targeting the ABL Myristoyl Pocket (STAMP) is used in the treatment of chronic myeloid leukemia. We describe a randomized, single-dose, open-label, four-period crossover study in healthy adult participants (N = 24) which evaluated the relative bioavailability of a single 40-mg dose of asciminib in pediatric formulation (1-mg mini-tablets) compared with the reference adult tablet under fasted conditions. Additionally, the effect of food on the bioavailability of the mini-tablet formulation was evaluated...
January 9, 2023: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/36615687/how-does-consistency-of-food-and-nutrition-support-effect-daily-food-consumption-among-children-living-in-poverty-recession-era-implications
#22
JOURNAL ARTICLE
Brittany R Schuler, Christian E Vazquez, Daphne C Hernandez
Underutilization of the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) and the Supplemental Nutrition Assistance (SNAP) food safety net programs may compromise child nutritional benefits for families with limited incomes. Using a sample of children surveyed before (2003-2006) and after the Great Recession (2007-2009), we examine whether consistent access to WIC and SNAP during times of increased economic stress moderated the association between poverty level (i.e., income-needs ratio [INR]) and fruits and vegetables (FV) or foods high in saturated fats and added sugars (SFAS)...
December 21, 2022: Nutrients
https://read.qxmd.com/read/36554499/micronutrient-biosynthesis-potential-of-spontaneous-grain-fermentation-microbiomes
#23
JOURNAL ARTICLE
Margaret I Dania, Bahram Faraji, James Wachira
Fermented foods play an important role in the human diet and particularly so in under-resourced environments where cold preservation is not attainable due to irregular supply of electricity. Fermented foods are reported to support gut health by contributing probiotics. The purpose of this study was to investigate the microbial diversity and metabolic potential of spontaneous millet fermentation. The literature in the field was reviewed and analyses were conducted on publicly available Sequence Read Archive (SRA) datasets...
December 10, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/36452051/predicting-hospice-transitions-in-dementia-caregiving-dyads-an-exploratory-machine-learning-approach
#24
JOURNAL ARTICLE
Suzanne S Sullivan, Wei Bo, Chin-Shang Li, Wenyao Xu, Yu-Ping Chang
BACKGROUND AND OBJECTIVES: Hospice programs assist people with serious illness and their caregivers with aging in place, avoiding unnecessary hospitalizations, and remaining at home through the end-of-life. While evidence is emerging of the myriad of factors influencing end-of-life care transitions among persons living with dementia, current research is primarily cross- sectional and does not account for the effect that changes over time have on hospice care uptake, access, and equity within dyads...
2022: Innovation in Aging
https://read.qxmd.com/read/36415469/characterizing-and-predicting-post-acute-sequelae-of-sars-cov-2-infection-pasc-in-a-large-academic-medical-center-in-the-us
#25
Lars G Fritsche, Weijia Jin, Andrew J Admon, Bhramar Mukherjee
OBJECTIVE: A growing number of Coronavirus Disease-2019 (COVID-19) survivors are affected by Post-Acute Sequelae of SARS CoV-2 infection (PACS). Using electronic health records data, we aimed to characterize PASC-associated diagnoses and to develop risk prediction models. METHODS: In our cohort of 63,675 COVID-19 positive patients, 1,724 (2.7 %) had a recorded PASC diagnosis. We used a case control study design and phenome-wide scans to characterize PASC-associated phenotypes of the pre-, acute-, and post-COVID-19 periods...
November 23, 2022: medRxiv
https://read.qxmd.com/read/36374594/impact-of-covid-19-on-a-community-health-coalition-and-its-residents-in-allegheny-county-pennsylvania-insights-into-adaptation-from-focus-groups-and-evaluation-reports
#26
JOURNAL ARTICLE
Stephanie N Christian, Andrea D Casas, Krissy Moehling Geffel, Tiffany L Gary-Webb, Hannah E Hardy, Roderick Harris, Dara D Mendez
Live Well Allegheny: Lifting Wellness for African Americans (LWA2 ) is a coalition in Allegheny County, Pennsylvania, funded by the Centers for Disease Control and Prevention's (CDC) Racial and Ethnic Approaches to Community Health (REACH) initiative. LWA2 consists of partner organizations addressing chronic disease prevention in six Black communities through nutrition, physical activity, and community-clinical linkage strategies. This analysis focuses on qualitative data exploring the influence of COVID-19 on coalition functioning and communities...
November 2022: Health Promotion Practice
https://read.qxmd.com/read/36337853/association-of-prenatal-modifiable-risk-factors-with-attention-deficit-hyperactivity-disorder-outcomes-at-age-10-and-15-in-an-extremely-low-gestational-age-cohort
#27
JOURNAL ARTICLE
David M Cochran, Elizabeth T Jensen, Jean A Frazier, Isha Jalnapurkar, Sohye Kim, Kyle R Roell, Robert M Joseph, Stephen R Hooper, Hudson P Santos, Karl C K Kuban, Rebecca C Fry, T Michael O'Shea
Background: The increased risk of developing attention-deficit hyperactivity disorder (ADHD) in extremely preterm infants is well-documented. Better understanding of perinatal risk factors, particularly those that are modifiable, can inform prevention efforts. Methods: We examined data from the Extremely Low Gestational Age Newborns (ELGAN) Study. Participants were screened for ADHD at age 10 with the Child Symptom Inventory-4 ( N = 734) and assessed at age 15 with a structured diagnostic interview (MINI-KID) to evaluate for the diagnosis of ADHD ( N = 575)...
2022: Frontiers in Human Neuroscience
https://read.qxmd.com/read/36304816/the-energy-density-of-meals-and-snacks-consumed-by-young-australian-adults-18-30-years-old-are-influenced-by-preparation-location-but-not-screen-use-nor-social-interactions-findings-from-the-mymeals-wearable-camera-study
#28
JOURNAL ARTICLE
Virginia Chan, Alyse Davies, Lyndal Wellard-Cole, Margaret Allman-Farinelli
The present study examined the association of contextual factors (social and food preparation location) with the energy density of meals and snacks consumed in a sample of young Australian adults (18-30 years old) identified using wearable camera technology. Over three consecutive days, a subsample of young adults wore a wearable camera that captured images in 30 s intervals. Eating episodes from 133 participants were annotated for preparation location and social context (covering social interaction and screen use)...
2022: Journal of Nutritional Science
https://read.qxmd.com/read/36228063/do-i-return-to-the-community-that-traumatized-me
#29
JOURNAL ARTICLE
Minna Wybrecht
I grew up on food stamps, unlike many of my medical school classmates. Prostitution and drug deals were regular occurrences in my neighborhood. A man was shot to death in front of my childhood home. After I left my hometown, I was finally able to heal from those devastating circumstances and build a safer life for myself. Difficult questions surfaced as I considered where I wanted to work as a physician. To gain more clarity, I chose to return to my hometown as part of a monthlong clinical elective. This experience facilitated vulnerable introspection...
September 2022: Annals of Family Medicine
https://read.qxmd.com/read/36225241/gammatile-comprehensive-review-of-a-novel-radioactive-intraoperative-seed-loading-device-for-the-treatment-of-brain-tumors
#30
REVIEW
Chukwuyem Ekhator, Ijeoma Nwankwo, Elya Rak, Ariel Homayoonfar, Ekokobe Fonkem, Ramin Rak
GammaTile is a Food and Drug Administration (FDA)-licensed device consisting of four cesium-131 (Cs-131) radiation-emitting seeds in the collagen tile about the postage stamp size. The tiles are utilized to line the brain cavity immediately after tumor resection. GammaTile therapy is a surgically targeted radiation therapy (STaRT) that helps provide instant, dose-intense treatment after the completion of resection. The objective of this study is to explore the safety and efficacy of GammaTile surgically targeted radiation therapy for brain tumors...
October 2022: Curēus
https://read.qxmd.com/read/36197958/asciminib-scemblix-a-third-line-treatment-option-for-chronic-myeloid-leukemia-in-chronic-phase-with-or-without-t315i-mutation
#31
JOURNAL ARTICLE
Shanada Monestime, Tiba Al Sagheer, Monica Tadros
DISCLAIMER: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: To review the pharmacology, efficacy, safety, dosing and administration, and place in therapy of asciminib, an oral tyrosine kinase inhibitor (TKI) used as a third-line treatment option for Philadelphia chromosome-positive chronic myeloid leukemia (CML) in chronic phase...
October 5, 2022: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/36143742/halochromic-inks-applied-on-cardboard-for-food-spoilage-monitorization
#32
JOURNAL ARTICLE
Liliana Leite, Inês Boticas, Miguel Navarro, Luís Nobre, João Bessa, Fernando Cunha, Pedro Neves, Raúl Fangueiro
Control of food spoilage is a critical concern in the current world scenario, not only to ensure the quality and safety of food but also to avoid the generation of food waste. This paper evaluates a dual-sensor strategy using six different pH indicators stamped on cardboard for the detection of spoilage in three different foods: beef, salmon, and strawberries. After function validation and formulation optimizations in the laboratory, the halochromic sensors methyl orange and bromocresol purple 2% ( w / v ) were stamped on cardboard and, in contact with the previously mentioned foods, were able to produce an easily perceptible signal for spoilage by changing color...
September 16, 2022: Materials
https://read.qxmd.com/read/36137149/how-do-low-income-single-mothers-get-by-when-unemployment-strikes-patterns-of-multiple-program-participation-after-transition-from-employment-to-unemployment
#33
JOURNAL ARTICLE
Chi-Fang Wu, Yu-Ling Chang, Soohyun Yoon, Salma Musaad
Little is known about longitudinal patterns of welfare program participation among single mothers after they transition from employment to unemployment. To better understand how utilization patterns of these welfare programs may change during the 12 months after a job loss, we used the 2008 Survey of Income and Program Participation to examine the patterns of participation in Medicaid, the Supplemental Nutrition Assistance Program, Temporary Assistance for Needy Families, and unemployment insurance among 342 single mothers who transitioned from employment to unemployment during the Great Recession...
2022: PloS One
https://read.qxmd.com/read/36067172/comparing-forms-of-neighborhood-instability-as-predictors-of-violence-in-richmond-va
#34
JOURNAL ARTICLE
Samuel J West, Diane Bishop, Derek A Chapman, Nicholas D Thomson
Violence events tend to cluster together geospatially. Various features of communities and their residents have been highlighted as explanations for such clustering in the literature. One reliable correlate of violence is neighborhood instability. Research on neighborhood instability indicates that such instability can be measured as property tax delinquency, yet no known work has contrasted external and internal sources of instability in predicting neighborhood violence. To this end we collected data on violence events, company and personal property tax delinquency, population density, race, income, food stamps, and alcohol outlets for each of Richmond, Virginia's 148 neighborhoods...
2022: PloS One
https://read.qxmd.com/read/35920249/purple-tea-water-extract-blocks-rankl-induced-osteoclastogenesis-through-modulation-of-akt-gsk3%C3%AE-and-blimp1-irf8-pathways
#35
JOURNAL ARTICLE
Yuxin Zhang, Jing Wang, Chenxu Jing, Ming-Xue Zhou, Wenqi Jin, Xiuci Yan, Huanhuan Hou, Kai Shi, Wan-Chun Sun, Liwei Sun
A number of studies demonstrated that some tea extracts exert inhibitory effects on osteoclastogenesis induced by receptor activator of nuclear factor κB ligand (RANKL). However, the effect of purple tea, a famous tea in China, on osteoclastogenesis remains unclear. In this study, a water-based purple tea extract (PTE) was found to suppress osteoclast formation, osteoclastic resorption pit area formation, and F-actin ring formation within RANKL-stimulated bone marrow macrophages (BMMs). Furthermore, our results demonstrated that PTE could inhibit expression of master transcription factors NFATc1 and c-Fos and their target genes DC-STAMP , Ctsk , and Atp6v0d2 ...
August 30, 2022: Food & Function
https://read.qxmd.com/read/35807936/snap-and-cardiometabolic-risk-in-youth
#36
JOURNAL ARTICLE
Katelin M Alfaro-Hudak, Lisa Schulkind, Elizabeth F Racine, Arthur Zillante
Increasing numbers of children and adolescents have unhealthy cardiometabolic risk factors and show signs of developing metabolic syndrome (MetS). Low-income populations tend to have higher levels of risk factors associated with MetS. The Supplemental Nutrition Assistance Program (SNAP) has the potential to reduce poverty and food insecurity, but little is known about how the program affects MetS. We examine the relationship between SNAP and the cardiometabolic risk factors in children and adolescents using regression discontinuity to control for unobserved differences between participants and nonparticipants...
July 2, 2022: Nutrients
https://read.qxmd.com/read/35807817/artificial-sweeteners-in-breast-milk-a-clinical-investigation-with-a-kinetic-perspective
#37
JOURNAL ARTICLE
Sofie Stampe, Magnus Leth-Møller, Eva Greibe, Elke Hoffmann-Lücke, Michael Pedersen, Per Ovesen
Artificial sweeteners (ASs) are calorie-free chemical substances used instead of sugar to sweeten foods and drinks. Pregnant women with obesity or diabetes are often recommended to substitute sugary products with ASs to prevent an increase in body weight. However, some recent controversy surrounding ASs relates to concerns about the risk of obesity caused by a variety of metabolic changes, both in the mother and the offspring. This study addressed these concerns and investigated the biodistribution of ASs in plasma and breast milk of lactating women to clarify whether ASs can transfer from mother to offspring through breast milk...
June 25, 2022: Nutrients
https://read.qxmd.com/read/35802253/mapping-of-pediatric-covid-19-cases-in-miami-dade-and-broward-counties-an-analysis-of-sociodemographic-disparities
#38
JOURNAL ARTICLE
Emily Bao, Lavanya Easwaran, Michael Maurer, Lisa Gwynn
BACKGROUND: Numerous studies have shown a disproportionate impact of COVID-19 infection on Black and Hispanic Americans in the adult patient population. However, few studies have been done with pediatric populations. The aim of this study is to identify the prevalence and distribution of COVID-19 cases among pediatric patients in Miami-Dade and Broward counties and identify any sociodemographic disparities. METHODS: A total of 10,087 children/adolescents ages zero years-old to 20 years-old were tested from July 1, 2020, to December 31, 2020...
July 8, 2022: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/35736420/computational-metabolomics-tools-reveal-metabolic-reconfigurations-underlying-the-effects-of-biostimulant-seaweed-extracts-on-maize-plants-under-drought-stress-conditions
#39
JOURNAL ARTICLE
Morena M Tinte, Keabetswe Masike, Paul A Steenkamp, Johan Huyser, Justin J J van der Hooft, Fidele Tugizimana
Drought is one of the major abiotic stresses causing severe damage and losses in economically important crops worldwide. Drought decreases the plant water status, leading to a disruptive metabolic reprogramming that negatively affects plant growth and yield. Seaweed extract-based biostimulants show potential as a sustainable strategy for improved crop health and stress resilience. However, cellular, biochemical, and molecular mechanisms governing the agronomically observed benefits of the seaweed extracts on plants are still poorly understood...
May 27, 2022: Metabolites
https://read.qxmd.com/read/35507557/the-affordable-care-act-medicaid-expansion-a-difference-in-differences-study-of-spillover-participation-in-snap
#40
JOURNAL ARTICLE
Paulette Cha, José J Escarce
The Affordable Care Act's Medicaid expansion to individuals with adults under 138 percent of the federal poverty level led to insurance coverage for millions of Americans in participating states. This study investigates Medicaid expansion's potential spillover participation in the Supplemental Nutrition Assistance Program (SNAP; formerly the Food Stamp Program). In addition to providing public insurance, the policy connects individuals to SNAP, affecting social determinants of health such as hunger. We use difference-in-differences regression to estimate the effect of the Medicaid expansion on SNAP participation among approximately 414,000 individuals from across the United States...
2022: PloS One
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