Yuxin Zhang, Jing Wang, Chenxu Jing, Ming-Xue Zhou, Wenqi Jin, Xiuci Yan, Huanhuan Hou, Kai Shi, Wan-Chun Sun, Liwei Sun
A number of studies demonstrated that some tea extracts exert inhibitory effects on osteoclastogenesis induced by receptor activator of nuclear factor κB ligand (RANKL). However, the effect of purple tea, a famous tea in China, on osteoclastogenesis remains unclear. In this study, a water-based purple tea extract (PTE) was found to suppress osteoclast formation, osteoclastic resorption pit area formation, and F-actin ring formation within RANKL-stimulated bone marrow macrophages (BMMs). Furthermore, our results demonstrated that PTE could inhibit expression of master transcription factors NFATc1 and c-Fos and their target genes DC-STAMP , Ctsk , and Atp6v0d2 ...
August 30, 2022: Food & Function