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https://www.readbyqxmd.com/read/27914365/developing-piperlongumine-directed-glutathione-s-transferase-inhibitors-by-an-electrophilicity-based-strategy
#1
Hai-Bo Wang, Xiao-Ling Jin, Jia-Fang Zheng, Fu Wang, Fang Dai, Bo Zhou
We report a case of successful design of glutathione S-transferase (GST) inhibitors via a natural product-inspired and electrophilicity-based strategy. Based on this strategy, a novel piperlongumine analog (PL-13) bearing a para-trifluoromethyl group and an α-chlorine on its aromatic and lactam rings, respectively, surfaced as a promising GST inhibitor, thereby overcoming cisplatin resistance in lung cancer A549 cells.
November 15, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27913437/surface-expression-of-tgf%C3%AE-docking-receptor-garp-promotes-oncogenesis-and-immune-tolerance-in-breast-cancer
#2
Alessandra Metelli, Bill X Wu, Caroline W Fugle, Saleh Rachidi, Shaoli Sun, Yongliang Zhang, Jennifer Wu, Stephen Tomlinson, Philip H Howe, Yi Yang, Elizabeth Garrett-Mayer, Bei Liu, Zihai Li
GARP encoded by the Lrrc32 gene is the cell surface docking receptor for latent TGFβ, which is expressed naturally by platelets and regulatory T cells (Treg). Although Lrrc32 is amplified frequently in breast cancer, the expression and relevant functions of GARP in cancer have not been explored. Here, we report that GARP exerts oncogenic effects, promoting immune tolerance by enriching and activating latent TGFβ in the tumor microenvironment. We found that human breast, lung, and colon cancers expressed GARP aberrantly...
October 20, 2016: Cancer Research
https://www.readbyqxmd.com/read/27911405/automated-robotic-dispensing-technique-for-surface-guidance-and-bioprinting-of-cells
#3
Ramya Bhuthalingam, Pei Q Lim, Scott A Irvine, Subbu S Venkatraman
This manuscript describes the introduction of cell guidance features followed by the direct delivery of cells to these features in a hydrogel bioink using an automated robotic dispensing system. The particular bioink was selected as it allows cells to sediment towards and sense the features. The dispensing system bioprints viable cells in hydrogel bioinks using a backpressure assisted print head. However, by replacing the print head with a sharpened stylus or scalpel, the dispensing system can also be employed to create topographical cues through surface etching...
November 18, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27909707/in-vitro-study-of-the-host-responses-to-model-biomaterials-via-a-fibroblast-macrophage-co-culture-system
#4
Guoying Zhou, Andrea Liedmann, Chandralekha Chatterjee, Thomas Groth
Surface properties are believed to play important roles in initial inflammatory and subsequent wound healing/fibrotic responses after implantation of biomaterials. To investigate the surface property effect in mediating these host responses, we used an in vitro fibroblast/macrophage co-culture model established with a cell migration chamber, and a series of self-assembling monolayers (SAMs) bearing different terminal groups as model surfaces to study the effect of surface properties on macrophage fusion, fibroblast attachment, spreading morphology, proliferation, outgrowth, as well as pro-(interleukin-6) and anti-(interleukin-10) inflammatory cytokine production, expression of ED-A fibronectin (FN) and alpha-smooth muscle actin (α-SMA)...
December 2, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27909665/autologous-osteophyte-grafting-for-open-wedge-high-tibial-osteotomy
#5
Takenori Akiyama, Ken Okazaki, Taro Mawatari, Satoshi Ikemura, Shunsuke Nakamura
Osteophytes are physiological bony outgrowths that develop at the margins of the articular surfaces during the progression of osteoarthritis; they are associated with active endochondral bone formation processes and expressions of various growth factors. We believe they could be a source of bone grafts as a result of a potentially strong osteoinductive effect. Moreover, osteophytes can be easily harvested by arthroscopy in patients undergoing open-wedge high tibial osteotomy (OW-HTO) for medial unicompartmental knee osteoarthritis...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27907917/simple-cysts-in-donor-kidney-contribute-to-reduced-allograft-function
#6
Wenxian Qiu, Yan Jiang, Jianyong Wu, Hongfeng Huang, Wenqing Xie, Xishao Xie, Jianghua Chen, Wenhan Peng
BACKGROUND: Simple renal cysts may be an early marker of renal disease. We investigated whether simple cysts in donor kidney are associated with the decline of allograft function in living donor kidney transplantation. METHODS: We retrospectively reviewed records of donors and recipients from 716 living donor kidney transplants performed between April 2007 and April 2015 in our hospital. Ninety-one donors with renal cysts and 64 recipients with cysts in donor kidney were noted...
December 2, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27907244/analyzing-the-dynamics-and-morphology-of-cast-off-pattern-at-different-speed-levels-using-high-speed-digital-video-imaging
#7
Sebastian Niko Kunz, Jiri Adamec, Christina Grove
During a bloodstain pattern analysis, one of the essential tasks is to distinguish between different kinds of applied forces as well as to estimate their level of intensity. In this study, high-speed digital imaging has been used to analyze the formation of cast-off patterns generated by a simulated backswing with a blood-bearing object. For this purpose, 0.5 mL blood was applied evenly over the last 5 cm of a blade simulant. Bloodstains were created through the controlled acceleration of a backswing at different speed levels between 1...
December 1, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27906137/in-vitro-toxicity-of-carbon-nanotube-polylysine-colloids-to-colon-cancer-cells
#8
Alejandro Ansón-Casaos, Laura Grasa, Desirée Pereboom, José Emilio Mesonero, Alvaro Casanova, María Divina Murillo, María Teresa Martínez
Single-walled carbon nanotubes (SWCNTs) are thoroughly purified and dispersed in an aqueous solution of high molecular weight poly-L-lysine (pLlys). Human intestinal epithelial Caco-2/TC7 cells are incubated with the SWCNT dispersions in pLlys, and their effects on cell viability are studied by image flow cytometry. No significant changes are observed in the cell culture wells up to pLlys concentrations of 10 μg ml(-1). However, high mortality is detected at pLlys concentrations of 100 μg ml(-1). The presence of oxygen-free SWCNTs does not modify the effects of pLlys on cell cultures at any of the tested concentrations (≤1 μg ml(-1))...
December 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27903299/arthroscopic-arthrodesis-for-ankle-arthritis-without-bone-graft
#9
Xiaojun Duan, Liu Yang, Li Yin
BACKGROUND: Ankle arthrodesis is considered by many to be the standard operative treatment for end-stage ankle arthritis. The purpose of this study was to perform a new technique for ankle joint surface and determine the outcome for the union rates of ankle arthroscopic arthrodesis. METHODS: A total of 68 patients with posttraumatic arthritis, primary osteoarthritis, and rheumatoid arthritis were treated by ankle arthroscopic arthrodesis between May 2007 and December 2012...
December 1, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27902245/streptomyces-luteus-sp-nov-a-novel-actinomycete-isolated-from-loulan-soil-of-xinjiang-china
#10
Xiaoxia Luo, Kai Liang, Yang Wang, Chuanxing Wan, Lili Zhang
A Streptomyces strain, designated TRM 45540T, was isolated from the soil of Loulan area(89°22'22″E, 40°29'55″N), Xinjiang Province, north-west China and was characterized taxonomically by using a polyphasic study. Phylogenetic analysis of the strain from 16S rRNA sequence revealed the strain TRM 45540 had 99.87% similarity with the type strain Streptomyces mutabilis NRRL12800T (GenBank accession number. AB184156). The strain was aerobic, gram-staining-positive, with an optimum NaCl concentration for growth of 5% (w/v)...
November 1, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27897344/single-molecule-conductance-studies-of-organometallic-complexes-bearing-3-thienyl-contacting-groups
#11
Sören Bock, Oday Al-Owaedi, Samantha Eaves, David Milan, Mario Lemmer, Brian Skelton, Henrry Osorio, Richard Nichols, Simon Higgins, Pilar Cea, Nicholas Long, Tim Albrecht, Santiago Martín, Colin Lambert, Paul J Low
The compounds and complexes 1,4-C6H4(C≡C-cyclo-3-C4H3S)2 (2), trans-Pt(C≡C-cyclo-3-C4H3S)2(PEt3)2 (3), trans-Ru(C≡C-cyclo-3-C4H3S)2(dppe)2 (4) and trans-Ru(C≡C-cyclo-3-C4H3S)2{P(OEt)3}4 (5) featuring the 3-thienyl moiety as a surface contacting group for gold electrodes have been prepared, crystallographically characterised in the case of 3 - 5, and studied in metal|molecule|metal junctions using both STM-I(s) and STM-BJ methods. The compounds exhibit similar conductance profiles, with a low conductance feature being more readily identified by STM-I(s) methods, and a higher feature by the STM-BJ method...
November 29, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27893932/density-driven-free-convection-model-for-isotopically-fractionated-geogenic-nitrate-in-sabkha-brine
#12
Warren W Wood, J K Böhlke
Subsurface brines with high nitrate (NO3(-) ) concentration are common in desert environments as atmospheric nitrogen is concentrated by the evaporation of precipitation and little nitrogen uptake. However, in addition to having an elevated mean concentration of ∼525 mg/L (as N), NO3- in the coastal sabkhas of Abu Dhabi is enriched in (15) N (mean δ(15) N ∼17‰), which is an enigma. A NO3(-) solute mass balance analysis of the sabkha aquifer system suggests that more than 90% of the nitrogen is from local atmospheric deposition and the remainder from ascending brine...
November 28, 2016: Ground Water
https://www.readbyqxmd.com/read/27893725/biredox-ionic-liquids-with-solid-like-redox-density-in-the-liquid-state-for-high-energy-supercapacitors
#13
Eléonore Mourad, Laura Coustan, Pierre Lannelongue, Dodzi Zigah, Ahmad Mehdi, André Vioux, Stefan A Freunberger, Frédéric Favier, Olivier Fontaine
Kinetics of electrochemical reactions are several orders of magnitude slower in solids than in liquids as a result of the much lower ion diffusivity. Yet, the solid state maximizes the density of redox species, which is at least two orders of magnitude lower in liquids because of solubility limitations. With regard to electrochemical energy storage devices, this leads to high-energy batteries with limited power and high-power supercapacitors with a well-known energy deficiency. For such devices the ideal system should endow the liquid state with a density of redox species close to the solid state...
November 28, 2016: Nature Materials
https://www.readbyqxmd.com/read/27892512/where-is-iron-in-erionite-a-multidisciplinary-study-on-fibrous-erionite-na-from-jersey-nevada-usa
#14
Alessandro F Gualtieri, Nicola Bursi Gandolfi, Simone Pollastri, Kilian Pollok, Falko Langenhorst
Fibrous erionite is a mineral fibre of great concern but to date mechanisms by which it induces cyto- and geno-toxic damage, and especially the role of iron associated to this zeolite species, remain poorly understood. One of the reasons is that we still don't know exactly where iron is in natural erionite. This work is focused on fibrous erionite-Na from Jersey (Nevada, USA) and attempts to draw a general model of occurrence of iron in erionite and relationship with toxicity mechanisms. It was found that iron is present as 6-fold coordinated Fe(3+) not part of the zeolite structure...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891088/an-emg-interface-for-the-control-of-motion-and-compliance-of-a-supernumerary-robotic-finger
#15
Irfan Hussain, Giovanni Spagnoletti, Gionata Salvietti, Domenico Prattichizzo
In this paper, we propose a novel electromyographic (EMG) control interface to control motion and joints compliance of a supernumerary robotic finger. The supernumerary robotic fingers are a recently introduced class of wearable robotics that provides users additional robotic limbs in order to compensate or augment the existing abilities of natural limbs without substituting them. Since supernumerary robotic fingers are supposed to closely interact and perform actions in synergy with the human limbs, the control principles of extra finger should have similar behavior as human's ones including the ability of regulating the compliance...
2016: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/27889840/five-to-thirteen-year-results-of-a-cemented-dual-mobility-socket-to-treat-recurrent-dislocation
#16
Moussa Hamadouche, Mickael Ropars, Camille Rodaix, Thierry Musset, François Gaucher, David Biau, Jean Pierre Courpied, Denis Huten
PURPOSE: Dual mobility (DM) socket has been associated with a low rate of dislocation following both primary and revision total hip arthroplasty (THA). However, little is known about the long-term efficiency of DM in the treatment of THA instability. The purpose of this retrospective study was to evaluate the outcome of a cemented DM socket to treat recurrent dislocation after a minimum of five year follow-up. METHODS: The series included 51 patients with a mean age of 71...
November 26, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27889241/natural-and-synthetic-coral-biomineralization-for-human-bone-revitalization
#17
REVIEW
David W Green, Besim Ben-Nissan, Kyung Sik Yoon, Bruce Milthorpe, Han-Sung Jung
Coral skeletons can regenerate replacement human bone in nonload-bearing excavated skeletal locations. A combination of multiscale, interconnected pores and channels and highly bioactive surface chemistry has established corals as an important alternative to using healthy host bone replacements. Here, we highlight how coral skeletal systems are being remolded into new calcified structures or synthetic corals by biomimetic processes, as places for the organized permeation of bone tissue cells and blood vessels...
November 23, 2016: Trends in Biotechnology
https://www.readbyqxmd.com/read/27889088/osteoblast-cellular-activity-on-low-elastic-modulus-ti-24nb-4zr-8sn-alloy
#18
K C Nune, R D K Misra, S J Li, Y L Hao, R Yang
OBJECTIVES: Low modulus β-titanium alloys with non-toxic alloying elements are envisaged to provide good biocompatibility and alleviate the undesired stress shielding effect. The objective of this study is to fundamentally elucidate the biological response of novel high strength-low elastic modulus Ti2448 alloy through the study of bioactivity and osteoblast cell functions. METHODS: Characterization techniques such as SEM, EDX, XRD, and fluorescence microscopy were utilized to analyze the microstructure, morphology, chemical composition, and cell adhesion...
November 23, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27888545/anti-angiogenic-therapy-affects-the-relationship-between-tumor-vascular-structure-and-function-a-correlation-study-between-micro-computed-tomography-angiography-and-dynamic-contrast-enhanced-mri
#19
Eugene Kim, Jana Kim, Gunhild Mari Maelandsmo, Berit Johansen, Siver Andreas Moestue
PURPOSE: To compare the effects of two anti-angiogenic drugs, bevacizumab and a cytosolic phospholipase A2-α inhibitor (AVX235), on the relationship between vascular structure and dynamic contrast enhanced (DCE)-MRI measurements in a patient-derived breast cancer xenograft model. METHODS: Mice bearing MAS98.12 tumors were randomized into three groups: bevacizumab-treated (n = 9), AVX235-treated (n = 9), and control (n = 8). DCE-MRI was performed pre- and post-treatment...
November 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27888460/metagenomic-analysis-reveals-the-contribution-of-anaerobic-methanotroph-1b-in-the-oxidation-of-methane-at-the-ulleung-basin-east-sea-of-korea
#20
Jin-Woo Lee, Kae Kyoung Kwon, Jang-Jun Bahk, Dong-Hun Lee, Hyun Sook Lee, Sung Gyun Kang, Jung-Hyun Lee
We have previously identified a sulfate methane transition zone (SMTZ) within the methane hydrate-bearing sediment in the Ulleung Basin, East Sea of Korea, and the presence of ANME-1b group in the sediment has been shown by phylogenetic analysis of a 16S rRNA gene. Herein, we describe taxonomic and functional profiling in the SMTZ sample by metagenomic analysis, comparing with that of surface sediment. Metagenomic sequences of 115 Mbp and 252 Mbp were obtained from SMTZ and surface sediments, respectively. The taxonomic profiling using BLASTX against the SEED within MG-RAST showed the prevalence of methanogens (19...
December 2016: Journal of Microbiology / the Microbiological Society of Korea
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