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https://www.readbyqxmd.com/read/28806709/in-vivo-kinematics-of-early-stage-osteoarthritic-knees-during-pivot-and-squat-activities
#1
Keisuke Matsuki, Kei O Matsuki, Tomonori Kenmoku, Satoshi Yamaguchi, Takahisa Sasho, Scott A Banks
Kinematic changes have been shown to accompany severe knee osteoarthritis, but no studies have analyzed early-stage osteoarthritic knee kinematics in the transverse plane during functional activities. The purpose of this study was to analyze kinematics of early-stage osteoarthritic knees using model registration techniques. Fifteen early-stage osteoarthritic knees from eight females with a mean age of 52 years old (range, 43-57years old) were involved in this study. A radiologist confirmed with plain radiographs that knees had Kellgren-Lawrence grade-1 or -2 arthritic changes...
August 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28804547/epha2-targeted-intratumoral-therapy-for-non-small-cell-lung-cancer-using-albumin-mesospheres
#2
Hung-Yen Lee, Kamal A Mohammed, Fredric Kaye, Brij M Moudgil, Najmunnisa Nasreen
Lung cancer, primarily non-small cell lung cancer (NSCLC), is the leading cause of cancer mortality and the prognosis of patients with advanced or metastatic NSCLC is poor. Despite significant advances in diagnosis and treatment, little improvement has been seen in NSCLC mortality. Recently, Intratumoral Chemotherapy, a direct local delivery of chemotherapeutic drugs, has shown promise in clinical studies. However, toxicity and high dosage of chemotherapeutic agents used for treatment are a limitation. Moreover, these drugs damage indiscriminately, cancerous as well as normal tissues...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28803479/design-of-cyclic-peptides-based-glucose-receptors-and-their-application-in-glucose-sensing
#3
Chao Li, Xin Chen, Fuyuan Zhang, Xingxing He, Guozhen Fang, Jifeng Liu, Shuo Wang
Glucose assay is of great scientific significance in clinical diagnostics and bioprocess monitoring and to design new glucose receptor is necessary for development of more sensitive, selective and robust glucose detection techniques. Herein, a series of cyclic peptides (CPs) glucose receptor were designed to mimic the binding sites of glucose binding protein (GBP) and CPs' sequence contained amino acid sites Asp, Asn, His, Asp, Arg, which constituted the first layer interactions of GBP. The properties of these CPs used as a glucose receptor or substitute for the GBP were studied by using quartz crystal microbalance (QCM) technique...
August 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28802257/oxidation-of-alkyl-benzenes-by-a-flavin-photooxidation-catalyst-on-nanostructured-metal-oxide-films
#4
Prateek Dongare, Ian MacKenzie, Degao Wang, David A Nicewicz, Thomas J Meyer
We describe here a surface-bound, oxide-based procedure for the photooxidation of a family of aromatic hydrocarbons by a phosphate-bearing flavin mononucleotide (FMN) photocatalyst on high surface area metal-oxide films.
August 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28801879/charging-and-release-mechanisms-of-flexible-macromolecules-in-droplets
#5
Myong In Oh, Styliani Consta
We study systematically the charging and release mechanisms of a flexible macromolecule, modeled by poly(ethylene glycol) (PEG), in a droplet by using molecular dynamics simulations. We compare how PEG is solvated and charged by sodium Na(+) ions in a droplet of water (H2O), acetonitrile (MeCN), and their mixtures. Initially, we examine the location and the conformation of the macromolecule in a droplet bearing no net charge. It is revealed that the presence of charge carriers do not affect the location of PEG in aqueous and MeCN droplets compared with that in the neutral droplets, but the location of the macromolecule and the droplet size do affect the PEG conformation...
August 11, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28800609/the-trypomastigote-small-surface-antigen-tssa-regulates-trypanosoma-cruzi-infectivity-and-differentiation
#6
María de Los Milagros Cámara, Gaspar E Cánepa, Andrés B Lantos, Virginia Balouz, Hai Yu, Xi Chen, Oscar Campetella, Juan Mucci, Carlos A Buscaglia
BACKGROUND: TSSA (Trypomastigote Small Surface Antigen) is an antigenic, adhesion molecule displayed on the surface of Trypanosoma cruzi trypomastigotes. TSSA displays substantial sequence identity to members of the TcMUC gene family, which code for the trypomastigote mucins (tGPI-mucins). In addition, TSSA bears sequence polymorphisms among parasite strains; and two TSSA variants expressed as recombinant molecules (termed TSSA-CL and TSSA-Sy) were shown to exhibit contrasting features in their host cell binding and signaling properties...
August 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28799772/optoelectronic-properties-of-semiconductor-quantum-dot-solids-for-photovoltaic-applications
#7
Alexander A Chistyakov, Mariya A Zvaigzne, Vladimir R Nikitenko, Alexey R Tameev, Igor L Martynov, Oleg V Prezhdo
Quantum dot (QD) solids represents a new type of condensed matter that is highly relevant from both fundamental and applied points of view. The properties of QD solids are qualitatively different from those of the traditional solids, and their unique characteristics give rise to promising applications. The combination of quantum confinement in individual QDs with macroscopic scale of the whole material leads to novel features of electronic excitations (excitons) and charge transfer processes, which are of great interest for optoelectronic applications...
August 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28798350/wet-tropical-climate-in-se-tibet-during-the-late-eocene
#8
Philippe Sorrel, Ines Eymard, Philippe-Herve Leloup, Gweltaz Maheo, Nicolas Olivier, Mary Sterb, Loraine Gourbet, Guocan Wang, Wu Jing, Haijian Lu, Haibing Li, Xu Yadong, Kexin Zhang, Kai Cao, Marie-Luce Chevalier, Anne Replumaz
Cenozoic climate cooling at the advent of the Eocene-Oligocene transition (EOT), ~33.7 Ma ago, was stamped in the ocean by a series of climatic events albeit the impact of this global climatic transition on terrestrial environments is still fragmentary. Yet archival constraints on Late Eocene atmospheric circulation are scarce in (tropical) monsoonal Asia, and the paucity of terrestrial records hampers a meaningful comparison of the long-term climatic trends between oceanic and continental realms. Here we report new sedimentological data from the Jianchuan basin (SE Tibet) arguing for wetter climatic conditions in monsoonal Asia at ~35...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796484/superhydrophobic-superoleophilic-and-reinforced-ethyl-cellulose-sponges-for-oil-water-separation-synergistic-strategies-of-cross-linking-carbon-nanotube-composite-and-nanosilica-modification
#9
Yeqiang Lu, Weizhong Yuan
Superhydrophobic/superoleophilic and reinforced ethyl cellulose (SEC) sponges were prepared by cross-linking EC with epichlorohydrin (ECH) and complexing with silanized carbon nanotubes (Si-CNTs) followed by coating nanosilica on the surface of porous sponges and subsequent modification with hexadecyltrimethoxysilane (HDTMS). These synergistic strategies endowed the SEC sponges with the superhydrophobic/superoleophilic properties (θwater=158.2°, θoil=0°, sliding angle=3°) and outstanding mechanical properties (could bear the pressure of 28...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28795083/mechanical-instability-and-titanium-particles-induce-similar-transcriptomic-changes-in-a-rat-model-for-periprosthetic-osteolysis-and-aseptic-loosening
#10
Mehdi Amirhosseini, Göran Andersson, Per Aspenberg, Anna Fahlgren
Wear debris particles released from prosthetic bearing surfaces and mechanical instability of implants are two main causes of periprosthetic osteolysis. While particle-induced loosening has been studied extensively, mechanisms through which mechanical factors lead to implant loosening have been less investigated. This study compares the transcriptional profiles associated with osteolysis in a rat model for aseptic loosening, induced by either mechanical instability or titanium particles. Rats were exposed to mechanical instability or titanium particles...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28792244/a-novel-%C3%AE-v%C3%AE-3-ligand-modified-hpma-copolymers-for-anticancer-drug-delivery
#11
Fengling Wang, Lian Li, Wei Sun, Lijia Li, Yuanyuan Liu, Yuan Huang, Zhou Zhou
The integrin αVβ3 receptor emerged as one of the most promising targets owing to its high expression on the surface of various malignant tumor cells and tumor angiogenesis endothelial cells, but with little expression in mature endothelial cells and the majority of normal cells. Here we report a new targeting ligand FQSIYPpIK (FQS) with high affinity to integrin αVβ3 receptor. To take the advantage of the particular interaction between FQS and integrin αVβ3 receptor, FQS was linked to N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers...
August 9, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28792042/sequestration-of-pb-zn-sb-and-as-bearing-incidental-nanoparticles-by-mineral-surface-coatings-and-mineralized-organic-matter-in-soils
#12
Michael Schindler, Michael F Hochella
Nanoparticles (NPs) often play significant roles in dictating the transport, distribution, bioavailability and toxicity of contaminants in the environment. Incidental NPs (i.e. NPs of anthropogenic origin but not purposely engineered) are often overlooked in contaminant transport and fate studies; yet in many systems they dominate contaminant transport processes. Using surficial contaminated regosols from Trail, British Columbia, Canada, a metal smelting and refining area along the banks of the Columbia River, we show that sequestration of Pb-, Zn-, Sb-, and As-bearing incidental NPs is strongly influenced by their aggregation, crystal growth, and/or particle attachment to mineral surface coatings (MSC) and in mineralized organic matter (MOM)...
August 16, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28791830/zirconium-the-material-of-the-future-in-modern-implantology
#13
REVIEW
Paweł Kubasiewicz-Ross, Marzena Dominiak, Tomasz Gedrange, Ute U Botzenhart
The authors present the contemporary state of knowledge concerning alternative materials for dental implantology. First of all, factors influencing osseointegration are stated. The most important factors seem to be the type of implant surface. Among the numerous parameters describing them, the most important are: average roughness and porous density. Some studies proved that materials with comparable surface roughness provide similar osseointegration. In modern implantology titanium is the material still considered as a "gold standard"...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28791454/-midcarpal-partial-arthrodesis-with-locking-plate-osteosynthesis
#14
REVIEW
J-F Hernekamp, U Kneser, T Kremer, B Bickert
OBJECTIVE: Preservation of residual mobility and pain reduction in the wrist in advanced carpal collapse (scapholunate advanced collapse, SLAC or scaphoid nonunion advanced collapse, SNAC). INDICATIONS: Advanced osteoarthritis of the radiocarpal and intercarpal articulations, SLAC/SNAC stages 2-3. CONTRAINDICATIONS: Arthrotic alterations to the proximal joint surface of the lunate bone or the corresponding joint surface of the radius (lunate fossa)...
August 8, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28790470/management-guidelines-for-metal-on-metal-hip-resurfacing-arthroplasty-a-strategy-on-followup
#15
Naoki Nakano, Andrea Volpin, Jonathan Bartlett, Vikas Khanduja
Despite the initial promise of metal-on-metal (MoM) implants as the ideal bearing surface for hip replacements and resurfacings, high short term failure rates due to an adverse reaction to metal debris (ARMD) have led to a dramatic reduction in the number of MoM implants used in the modern era. With over one million patients worldwide having undergone hip operations utilizing a MoM bearing surface, the long term outcomes for such patients remains unknown, and there is much debate as to the most effective management of these patients...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28790469/outcomes-following-total-hip-arthroplasty-a-review-of-the-registry-data
#16
Ajay Malviya, Nicole Abdul, Vikas Khanduja
While total hip arthroplasty remains one of the most reliable procedures with excellent, cost-effective outcomes, there remains controversy in the choice of implant in terms of method of fixation, bearing surface, and size of the femoral head, especially in the younger population. This review looks at the possible information base that surgeons can explore before choosing the implant that they are comfortable with. It also looks at the findings of various registries, which readers can use in the process of informed consent...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28783555/hamstring-and-calf-muscle-activation-as-a-function-of-bodyweight-support-during-treadmill-running-in-acl-reconstructed-athletes
#17
Clint Hansen, Einar Einarson, Athol Thomson, Rodney Whiteley, Erik Witvrouw
Rehabilitation after injury and reconstruction to the anterior cruciate ligament is thought to require a gradual reintroduction of loading, particularly during resumption of running. One strategy to achieve this is via the use of a reduced-gravity treadmill but it is unknown, if and how muscle activity varies in the reduced gravity conditions compared to regular treadmill running. Nineteen healthy participants and 18 male patients at the end of their rehabilitation (8 with a bone-patellar-bone graft, 10 with a hamstring graft) participated in this multi-muscle surface electromyography (sEMG) running study...
July 29, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28783505/surface-modification-of-docetaxel-nanocrystals-with-her2-antibody-to-enhance-cell-growth-inhibition-in-breast-cancer-cells
#18
Jin-Seok Choi, Jeong-Sook Park
Here, we describe docetaxel nanocrystals (DTX-NCs) surface-modified with Herceptin(®) (HCT) for combination cancer therapy. Using nano-precipitation and adsorption method, DTX-NCs and HCT-DTX-NCs were successfully prepared. The morphologies of DTX-NCs and HCT-DTX-NCs were characterized by field emission scanning electron microscopy (FE-SEM). The particle size and surface charge were evaluated by zeta-sizer and zeta-potential, respectively. Moreover, DTX-NCs and HCT-DTX-NCs were evaluated in terms of an in vitro drug release, cellular uptake and cytotoxicity...
July 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28783345/influence-of-multidirectional-interactions-on-domain-size-and-shape-of-2-d-molecular-assemblies
#19
Nobuhiko Nishitani, Takashi Hirose, Kenji Matsuda
The effect of molecule-molecule interactions on the size and shape of 2-D ordering domains was investigated using scanning tunneling microscopy (STM) at the liquid/solid interface. Synthesized alkoxybenzene derivatives bearing amide group tend to form very large domains of 2-D orderings (> 0.25 μm(2)), whereas the domain size of corresponding urea derivatives was significantly small in the same condition. The quantitative analysis of the concentration dependence of surface coverage using a nucleation-elongation model suggests that the replacement of amide functionality by urea increased equilibrium constant of the nucleation process of 2-D self-assembly, which is a key factor for the domain size at the liquid/solid interface...
August 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28783175/contribution-of-vascular-endothelial-growth-factor-receptor-2-sialylation-to-the-process-of-angiogenesis
#20
P Chiodelli, S Rezzola, C Urbinati, F Federici Signori, E Monti, R Ronca, M Presta, M Rusnati
Vascular endothelial growth factor receptor-2 (VEGFR2) is the main pro-angiogenic receptor expressed by endothelial cells (ECs). Using surface plasmon resonance, immunoprecipitation, enzymatic digestion, immunofluorescence and cross-linking experiments with specific sugar-binding lectins, we demonstrated that VEGFR2 bears both α,1-fucose and α(2,6)-linked sialic acid (NeuAc). However, only the latter is required for VEGF binding to VEGFR2 and consequent VEGF-dependent VEGFR2 activation and motogenic response in ECs...
August 7, 2017: Oncogene
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