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https://www.readbyqxmd.com/read/29452304/the-chondrocyte-channelome-a-narrative-review
#1
Ali Mobasheri, Csaba Matta, Ilona Uzielienè, Emma Budd, Pablo Martín-Vasallo, Eiva Bernotiene
Chondrocytes are the main cells in the extracellular matrix of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29448734/wear-resistance-properties-reinforcement-using-nano-al-cu-composite-coating-in-sliding-bearing-maintenance
#2
Hongtao Liu, Zhixiong Li, Jianmei Wang, Chenxing Sheng, Wanli Liu
Sliding bearing maintenance is crucial for reducing the cost and extending the service life. An efficient and practical solution is to coat a restorative agent onto the worn/damaged bearings. Traditional pure-copper (Cu) coating results in a soft surface and poor abrasion resistance. To address this issue, this paper presents a nano-composite repairing coating method. A series of nano-Al/Cu coatings were prepared on the surface of 45 steel by composite electro-brush plating (EBP). Their micro-hardness was examined by a MHV-2000 Vickers hardness tester, and tribological properties by a UMT-2M Micro-friction tester, 3D profiler and SEM...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448515/polyalkylene-glycol-based-lubricants-and-tribological-behaviour-role-of-ionic-liquids-and-graphene-oxide-as-additives
#3
Adolfo Senatore, Mario Pisaturo, Domenico Guida
The polyalkylene glycol (PAG) lubricants are widely used as gear, bearing and compressor oils in refrigerant systems. They are designed to provide outstanding benefits in terms of efficiency, long oil life, and equipment protection. These fully synthetic lubricants have been developed for use under operating conditions beyond the capabilities of other synthetic lubricants and mineral oils as their characteristic low pour point ensures excellent fluidity at low-temperature. On the other hand, the main drawback of PAG oils is the marked hygroscopicity, i...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447433/a-step-into-the-future-applications-of-nanoparticle-enzyme-mimics
#4
Wolfgang Tremel, Karsten Korschelt, Muhammad Nawaz Tahir
We describe elementary concepts, up-to-date developments, and per-spectives of the emerging field of nanoparticle enzyme mimics (so-called "nanozymes") at the interface of chemistry, biology, materials, and nanotechnology. The design and synthesis of functional enzyme mimics is a long-standing goal of biomimetic chemistry. Metal com-plexes, polymers and engineered biomolecules capturing the structure of natural enzymes or their active centers have been made to achieve high rates and enhanced selectivities...
February 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29444576/-fractures-of-the-fifth-metatarsal-base
#5
K Bušková, D Kuběnová, M Tuček
Fractures of the fifth metatarsal base are among the most common fractures of the foot. They are typically caused by indirect violence during sports activities. This region is also a site where stress fractures occur frequently. Diagnosis is based on the patients medical history, clinical examination and imaging methods. The fundamental imaging method is radiography of the foot in three views. MRI is used primarily for early diagnosis of stress fractures. CT examination is beneficial mainly in complex foot injuries, in order to rule out associated fractures...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29443774/sanders-type-iiiab-calcaneal-fracture-without-broken-lateral-wall-a-case-report-and-review-of-literature
#6
Zhenshuang Yue, Yanghua Tang, Zhongqing Hu, Wenjie Zheng
RATIONALE: The calcaneal fracture without broken lateral wall is rare and the open anatomic reduction and internal fixation (ORIF) is necessary when the subtalar joint articular surface is broken and collapsed. PATIENT CONCERNS: A 45-year-old male was admitted to our department with complaints of heel pain and swelling after falling down from 1-m-high stone. He was unable to bear weight on his right foot. DIAGNOSES: Imaging studies confirmed that it was a sanders type IIIAB calcaneal fracture without broken lateral wall and the middle part of the posterior calcaneal articular facet collapsed...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443507/three-dimensional-directionality-is-a-pivotal-structural-feature-for-the-bioactivity-of-azabisphosphonate-capped-poly-phosphorhydrazone-nanodrug-dendrimers
#7
Myriam Hayder, Matteo Garzoni, Davide Bochicchio, Anne-Marie Caminade, François Couderc, Varravaddheay Ong-Meang, Jean-Luc Davignon, Cédric-Olivier Turrin, Giovanni M Pavan, Remy Poupot
Dendrimers are nanosized, non-linear, hyperbranched polymers whose overall three-dimensional shape is key for their biological activity. Poly(PhosphorHydrazone) (PPH) dendrimers capped with aza-bisphosphonate (ABP) end groups are known to have anti-inflammatory properties enabling the control of inflammatory diseases in different mouse models. Here we screen the anti-inflammatory activity of a series of PPH bearing between 2 and 16 ABP end groups in a mouse model of arthritis, and confront the biological results with atomistic simulations of the dendrimers...
February 14, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29439670/phase-i-study-of-an-active-immunotherapy-for-asymptomatic-phase-lymphoplasmacytic-lymphoma-with-dna-vaccines-encoding-antigen-chemokine-fusion-study-protocol
#8
Sheeba K Thomas, Soung-Chul Cha, D Lynne Smith, Kun Hwa Kim, Sapna R Parshottam, Sheetal Rao, Michael Popescu, Vincent Y Lee, Sattva S Neelapu, Larry W Kwak
BACKGROUND: There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding strongly supports the use of cancer vaccine strategies. Lymphoplasmacytic lymphoma (LPL) is a low grade, incurable disease featuring an abnormal proliferation of Immunoglobulin (Ig)-producing malignant cells...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29437277/identification-of-native-and-post-translationally-modified-hla-b-57-01-restricted-hiv-envelope-derived-epitopes-using-immunoproteomics
#9
Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda W S Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane Thomas, Stephen J Kent, Nicola Ternette, Damian F J Purcell, Jamie Rossjohn, Anthony W Purcell
The recognition of pathogen-derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antigens are degraded in the cytosol and short peptides assemble with class I human leukocyte antigen (HLA) molecules in the endoplasmic reticulum (ER). These peptide-HLA complexes egress to the cell surface and are scrutinized by cytotoxic CD8+ T-cells leading to the eradication of the infected cell. Here we identify naturally presented HLA-B*57:01 bound peptides derived from the envelope protein of the human immunodeficiency virus (HIVenv)...
February 13, 2018: Proteomics
https://www.readbyqxmd.com/read/29437054/the-effect-of-bearing-surface-on-risk-of-periprosthetic-joint-infection-in-total-hip-arthroplasty-a-systematic-review-and-meta-analysis
#10
REVIEW
A T Hexter, S M Hislop, G W Blunn, A D Liddle
AIMS: Periprosthetic joint infection (PJI) is a serious complication of total hip arthroplasty (THA). Different bearing surface materials have different surface properties and it has been suggested that the choice of bearing surface may influence the risk of PJI after THA. The objective of this meta-analysis was to compare the rate of PJI between metal-on-polyethylene (MoP), ceramic-on-polyethylene (CoP), and ceramic-on-ceramic (CoC) bearings. PATIENTS AND METHODS: Electronic databases (Medline, Embase, Cochrane library, Web of Science, and Cumulative Index of Nursing and Allied Health Literature) were searched for comparative randomized and observational studies that reported the incidence of PJI for different bearing surfaces...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29435992/feasibility-and-safety-of-a-cemented-peek-on-pe-knee-replacement-in-a-goat-model-a-preliminary-study
#11
Zhe Du, Zhonglin Zhu, Bing Yue, Zhanchun Li, You Wang
Polyether-ether-ketone (PEEK) is a potential alternative to metal alloys for use in the orthopedic implants; however, an in vivo study in an appropriate animal model is essential and has not yet been initiated. The aim of the present study was to gather some preliminary evidence regarding the performance and safety of a cemented PEEK-based knee replacement device in a goat model. Fifteen adult goats were randomly divided into two groups; the control group (n = 5), which received a sham operation, and the experimental group (n = 10), which received a total knee arthroplasty with a PEEK-based knee replacement device...
February 13, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29435764/histochemical-examination-on-the-peri-implant-bone-with-early-occlusal-loading-after-the-immediate-placement-into-extraction-sockets
#12
Yoshiki Ikeda, Tomoka Hasegawa, Tomomaya Yamamoto, Paulo Henrique Luiz de Freitas, Kimimitsu Oda, Akiko Yamauchi, Atsuro Yokoyama
Early and immediate loading of dental implants has become a routine procedure in dental practices throughout the world, but the histological feature of peri-implant bone has not been fully understood. Therefore, we aimed to elucidate the histological response of peri-implant bone bearing the early occlusal loading using rat models. Four-week-old male Wistar rats were subjected to extraction of their maxillary left first molars and had titanium implants inserted immediately into the post-extraction sockets. In experimental groups at 1 week after placement, implants were loaded for 1 or 2 weeks by adding adhesive resin on the top of the screws...
February 12, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29432984/high-strength-biodegradable-and-cytocompatible-alpha-tricalcium-phosphate-iron-composites-for-temporal-reduction-of-bone-fractures
#13
E B Montufar, M Casas-Luna, M Horynová, S Tkachenko, Z Fohlerová, S Diaz-de-la-Torre, K Dvorak, L Celko, J Kaiser
In this work alpha tricalcium phosphate (α-TCP)/ iron (Fe) composites were developed as a new family of biodegradable, load-bearing and cytocompatible materials. The composites with composition from pure ceramic to pure metallic samples were consolidated by pulsed electric current assisted sintering to minimise processing time and temperature while improving their mechanical performance. The mechanical strength of the composites was increased and controlled with the Fe content, passing from brittle to ductile failure...
February 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29432270/what-is-the-long-term-survival-for-primary-tha-with-small-head-metal-on-metal-bearings
#14
Richard de Steiger, Andrea Peng, Peter Lewis, Stephen Graves
BACKGROUND: Large-head metal-on-metal (MoM) bearing hip replacements have been shown to have a much higher rate of revision than other bearing surfaces. However, small-head (≤ 32 mm) MoM bearing surfaces have been in use for many years with several reports of satisfactory mid- to long-term survivorship. It is unclear whether the long-term survival of small-head MoM devices will continue to be satisfactory or whether the same concerns seen with the large-head MoM devices will ultimately become more prevalent...
February 8, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29432024/evaluation-of-muc-1-aptamer-functionalized-hybrid-nanoparticles-for-targeted-delivery-of-mirna-29b-to-non-small-cell-lung-cancer
#15
Maryna Perepelyuk, Koita Sacko, Karthik Thangavel, Sunday A Shoyele
The objective of this study was to evaluate the therapeutic efficacy and pharmacokinetic study of mucin1-aptamer functionalized miRNA-29b-loaded hybrid nanoparticles (MAFMILHN) in lung tumor-bearing SCID mice. MAFMILHN were manufactured using an iso-electric point based nanotechnology. They were then fully characterized for particle size, loading capacity, Zeta potential and encapsulation efficiency. The ability of MAFMILHN to downregulate oncoprotein DNMT3B both at the cellular level and in vivo was monitored using western blot, while the effect of the downregulation of DNMT3B on tumor growth was assessed using bioluminescence...
February 12, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29432001/light-sensitive-alkoxyamines-as-versatile-spatially-and-temporally-controlled-precursors-of-alkyl-radicals-and-nitroxides
#16
Marc Baron, Jason C Morris, Siham Telitel, Jean-Louis Clément, Jacques Lalevée, Fabrice Morlet-Savary, Arnaud Spangenberg, Jean-Pierre Malval, Olivier Soppera, Didier Gigmes, Yohann Guillaneuf
The use of UV/visible light irradiation as a means to initiate organic syntheses is increasingly attractive due to the high spatial and temporal control conferred by photochemical processes. The aim of this work is thus to demonstrate that alkoxyamines bearing a chromophore on the alkyl moiety can provide a photo-protecting group for the sensitive nitroxide functionality, that is known to degrade through redox processes. The dissociation of various photosensitive alkoxyamines was studied from 223 K to 298 K under UV/visible irradiation, depending on the nature of the chromophore...
February 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29431748/effects-of-1-hexanol-on-c12e10-micelles-a-molecular-simulations-and-light-scattering-study
#17
Sampsa Vierros, Maria Sammalkorpi
The micelles of the non-ionic C12E10 surfactant and 1-hexanol as an aqueous solution additives are studied toward the purpose of understanding the role of alcohol additives in tuning the characteristics of alkyl-ethoxylate micellar systems. Our dynamic light scattering and cloud point experiments show that the addition of hexanol induces a response similar to an increase of temperature. We associate the change with increased attraction between the micelles at low to moderate hexanol loadings and a potential increase of the aggregate size at a high hexanol-to-surfactant ratio...
February 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29430920/long-term-experimental-acidification-drives-watershed-scale-shift-in-dissolved-organic-matter-composition-and-flux
#18
Michael D SanClements, Ivan J Fernandez, Robert A Lee, Joshua A Roberti, Mary Beth Adams, Garret A Rue, Diane M McKnight
Over the last several decades dissolved organic carbon concentrations (DOC) in surface waters have increased throughout much of the northern hemisphere. Several hypotheses have been proposed regarding the drivers of this phenomenon including decreased sulfur (S) deposition working via an acidity- change mechanism. Using fluorescence spectroscopy and data from two long-term (24+ years at completion of this study) whole watershed acidification experiments, that is, the Bear Brook Watershed in Maine (BBWM) and Fernow Experimental Forest in West Virginia (FEF) allowed us to control for factors other than the acidity-change mechanism (e...
February 12, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29429884/midterm-prospective-comparative-analysis-of-2-hard-on-hard-bearing-total-hip-arthroplasty-designs
#19
J Ryan Martin, Jason M Jennings, Tyler S Watters, Dan L Levy, Todd M Miner, Douglas A Dennis
INTRODUCTION: Hard-on-hard (HoH) bearing surfaces in total hip arthroplasty (THA) are commonly utilized in younger patients and may decrease mechanical wear compared to polyethylene bearing surfaces. To our knowledge, no study has prospectively compared the 2 most common HoH bearings, ceramic-on-ceramic (CoC) and metal-on-metal (MoM) THA. MATERIALS AND METHODS: We prospectively enrolled 40 patients to undergo an MoM THA and 42 patients to undergo a CoC THA utilizing the same acetabular component...
January 31, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29429883/total-hip-arthroplasty-bearing-surface-trends-in-the-united-states-from-2007-to-2014-the-rise-of-ceramic-on-polyethylene
#20
Nathanael D Heckmann, Lakshmanan Sivasundaram, Michael D Stefl, Hyunwoo Paco Kang, Eric T Basler, Jay R Lieberman
BACKGROUND: Wear of the bearing surface is a critical element in determining the longevity of a total hip arthroplasty (THA). Over the past decade, concerns related to modern metal-on-metal (MoM) bearings and corrosion at the femoral head-neck interface have influenced surgeon selection of bearing surfaces. The purpose of this study is to analyze trends in THA bearing surface selection from 2007 through 2014 using a large national database. METHODS: The Nationwide Inpatient Sample database was used to extract bearing surface data from patients who underwent a primary THA between 2007 and 2014...
January 9, 2018: Journal of Arthroplasty
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