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https://www.readbyqxmd.com/read/29224003/human-leukocyte-antigen-g-inhibits-the-anti-tumor-effect-of-natural-killer-cells-via-immunoglobulin-like-transcript-2-in-gastric-cancer
#1
Rui Wan, Zi-Wei Wang, Hui Li, Xu-Dong Peng, Guang-Yi Liu, Jun-Ming Ou, An-Qi Cheng
BACKGROUND/AIMS: Human leukocyte antigen-G (HLA-G) plays an important role in inhibiting natural killer (NK) cell function and promoting immune escape. However, the specific mechanism of HLA-G on NK in gastric cancer (GC) remains not well understood. This study investigated the expression of HLA-G in GC and the role of HLA-G-effected NK cells in GC progression. METHODS: HLA-G expression in GC tissues obtained from 49 patients with GC was analyzed by immunohistochemistry and western blot...
December 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29221170/proteoglycan-targeting-applied-to-hypoxia-activated-prodrug-therapy-in-chondrosarcoma-first-proof-of-concept
#2
Aurélien Voissiere, Valérie Weber, Yvain Gerard, Françoise Rédini, Florian Raes, Jean-Michel Chezal, Françoise Degoul, Caroline Peyrode, Elisabeth Miot-Noirault
Due to its abundant chondrogenic matrix and hypoxic tissue, chondrosarcoma is chemo- and radio-resistant. Our group has developed a proteoglycan targeting strategy by using a quaternary ammonium (QA) function as a carrier of DNA alkylating agents to chondrosarcoma environment. Here, we assessed the relevance of this strategy applied to hypoxia-activated prodrugs, by conjugating a QA to 2-nitroimidazole phosphoramidate. This derivative, named as 8-QA, was evaluated respectively to its non-QA equivalent and to a QA-conjugated but non-hypoxia activated...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215020/simultaneously-improving-the-mechanical-and-electrical-properties-of-poly-vinyl-alcohol-composites-by-high-quality-graphitic-nanoribbons
#3
Ming Yang, Lin Weng, Hanxing Zhu, Fan Zhang, Tongxiang Fan, Di Zhang
Although carbon nanotubes (CNTs) have shown great potential for enhancing the performance of polymer matrices, their reinforcement role still needs to be further improved. Here we implement a structural modification of multi-walled CNTs (MWCNTs) to fully utilize their fascinating mechanical and electrical properties via longitudinal splitting of MWCNTs into graphitic nanoribbons (GNRs). This nanofiller design strategy is advantageous for surface functionalization, strong interface adhesion as well as boosting the interfacial contact area without losing the intrinsic graphitic structure...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212929/nucleic-acid-polymers-are-active-against-hepatitis-delta-virus-infection-in-vitro
#4
Frauke Beilstein, Matthieu Blanchet, Andrew Vaillant, Camille Sureau
In this study, an in vitro infection model for the hepatitis delta virus (HDV) was used to evaluate the antiviral effects of phosphorothioate nucleic acid polymers (NAPs) and investigate their mechanism of action. The results show that NAPs inhibit HDV infection at less than 4 micromolar concentrations in cultures of differentiated human hepatoma cells. NAPs were shown to be active at viral entry, but inactive post entry on HDV RNA replication. Inhibition was independent of the NAPs nucleotide sequence, but dependent on both size and amphipathicity of the polymer...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29212907/role-of-the-ehd-family-of-endocytic-recycling-regulators-for-tcr-recycling-and-t-cell-function
#5
Fany M Iseka, Benjamin T Goetz, Insha Mushtaq, Wei An, Luke R Cypher, Timothy A Bielecki, Eric C Tom, Priyanka Arya, Sohinee Bhattacharyya, Matthew D Storck, Craig L Semerad, James E Talmadge, R Lee Mosley, Vimla Band, Hamid Band
T cells use the endocytic pathway for key cell biological functions, including receptor turnover and maintenance of the immunological synapse. Some of the established players include the Rab GTPases, the SNARE complex proteins, and others, which function together with EPS-15 homology domain-containing (EHD) proteins in non-T cell systems. To date, the role of the EHD protein family in T cell function remains unexplored. We generated conditional EHD1/3/4 knockout mice using CD4-Cre and crossed these with mice bearing a myelin oligodendrocyte glycoprotein-specific TCR transgene...
December 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29212681/ten-year-follow-up-study-of-three-alternative-bearing-surfaces-used-in-total-hip-arthroplasty-in-young-patients-a-prospective-randomised-controlled-trial
#6
A Atrey, S E Ward, A Khoshbin, N Hussain, E Bogoch, E H Schemitsch, J P Waddell
AIMS: We present the ten-year data of a cohort of patients, aged between 18 and 65 years (mean age 52.7 years; 19 to 64), who underwent total hip arthroplasty. Patients were randomised to be treated with a cobalt-chrome (CoCr) femoral head with an ultra-high molecular weight polyethylene (UHMWPE), highly cross-linked polyethylene (XLPE) or ceramic-on-ceramic (CoC) bearing surface. PATIENTS AND METHODS: A total of 102 hips (91 patients) were randomised into the three groups...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29211963/dynamic-organization-of-ligand-grafted-nanoparticles-during-adsorption-and-surface-compression-at-fluid-fluid-interfaces
#7
Axel Huerre, Fernando Cacho-Nerin, Vincent Poulichet, Christiana E Udoh, Marco De Corato, Valeria Garbin
Monolayers of ligand-grafted nanoparticles at fluid interfaces exhibit a complex response to deformation due to an interplay of particle rearrangements within the monolayer, and molecular rearrangements of the ligand brush on the surface of the particles. We use grazing-incidence small-angle X-ray scattering (GISAXS) combined with pendant drop tensiometry to probe in situ the dynamic organization of ligand-grafted nanoparticles upon adsorption at a fluid-fluid interface, and during monolayer compression. Through the simultaneous measurements of interparticle distance, obtained from GISAXS, and of surface pressure, obtained from pendant drop tensiometry, we link the interfacial stress to the monolayer microstructure...
December 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29211363/hierarchical-potential-differentiation-of-liver-cancer-stem-cells
#8
REVIEW
Wenfeng Zhang, Di Mu, Kai Feng
Hepatocellular carcinoma (HCC) is one of the most malignant tumors in Chinese people and offers poor prognosis. Tumor tissue, like normal tissue, is hierarchically differentiated. Thus, minor tumor cell populations able to differentiate, such as stem cells, sustain tumor self-renewal and proliferation. The fact that liver cancer stem cells (CSCs) with different surface markers appear heterogeneous with respect to oncogenesis and drug resistance indicates that subpopulations of surface markers preserve the hierarchical potential of differentiation during proliferation, deterioration and relapse...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29210416/biexciton-and-trion-energy-transfer-from-cdse-cds-giant-nanocrystals-to-si-substrates
#9
Tianle Guo, Siddharth Sampat, Sara M Rupich, Jennifer A Hollingsworth, Matthew Buck, Han Htoon, Yves J Chabal, Yuri N Gartstein, Anton V Malko
Observation of energy transfer (ET) from multiexcitonic (MX) complexes in nanocrystal quantum dots (NQDs) has been severely restricted due to efficient nonradiative Auger recombination leading to very low MX emission quantum yields. Here we employed "giant" CdSe/CdS NQDs with suppressed Auger recombination to study ET of biexcitons (BX) and charged excitons (trions) into Si substrate. Photoluminescence (PL) measurements of (sub)monolayers of gNQDs controllably assembled on various interacting surfaces and augmented by single gNQD's imaging reveal appearance of BX spectral signatures and progressive acceleration of PL lifetimes of all excitonic species on Si substrates...
December 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/29210267/ultrafast-photodynamics-of-glucose
#10
Jens Petersen, Joachim O Lindner, Roland Mitric
We have investigated the photodynamics of $\beta$-D-glucose employing our field-induced surface hopping method (FISH), which allows us to simulate the coupled electron-nuclear dynamics, including explicitly nonadiabatic effects and light-induced excitation. Our results reveal that from the initially populated S$_{1}$ and S$_{2}$ states, glucose returns nonradiatively to the ground state within about 200 fs. This takes place mainly via conical intersections (CIs) whose geometries in most cases involve the elongation of a single O-H bond, while in some instances ring-opening due to dissociation of a C-O bond is observed...
December 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29209661/origami-lattices-with-free-form-surface-ornaments
#11
Shahram Janbaz, Niels Noordzij, Dwisetya S Widyaratih, Cornelis W Hagen, Lidy E Fratila-Apachitei, Amir A Zadpoor
Lattice structures are used in the design of metamaterials to achieve unusual physical, mechanical, or biological properties. The properties of such metamaterials result from the topology of the lattice structures, which are usually three-dimensionally (3D) printed. To incorporate advanced functionalities into metamaterials, the surface of the lattice structures may need to be ornamented with functionality-inducing features, such as nanopatterns or electronic devices. Given our limited access to the internal surfaces of lattice structures, free-form ornamentation is currently impossible...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29209163/voluntary-ambulation-by-upper-limb-triggered-hal%C3%A2-in-patients-with-complete-quadri-paraplegia-due-to-chronic-spinal-cord-injury
#12
Yukiyo Shimizu, Hideki Kadone, Shigeki Kubota, Kenji Suzuki, Tetsuya Abe, Tomoyuki Ueno, Yuichiro Soma, Yoshiyuki Sankai, Yasushi Hada, Masashi Yamazaki
Patients with complete paraplegia after spinal cord injury (SCI) are unable to stand or walk on their own. Standing exercise decreases the risk of decubitus ulcers, osteoporosis, and joint deformities in patients with SCI. Conventional gait training for complete paraplegia requires excessive upper limb usage for weight bearing and is difficult in cases of complete quadriplegia. The purpose of this study was to describe voluntary ambulation triggered by upper limb activity using the Hybrid Assistive Limb® (HAL) in patients with complete quadri/paraplegia after chronic SCI...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29208853/investigations-of-cartilage-matrix-degeneration-in-patients-with-early-stage-femoral-head-necrosis
#13
Ronghua Xu, Bo Wei, Jiayi Li, Chenyu Huang, Rongcai Lin, Cheng Tang, Yan Xu, Qingqiang Yao, Liming Wang
BACKGROUND The purpose of this study was to explore changes in cartilage matrix in early-stage femoral head necrosis (FHN). MATERIAL AND METHODS Femoral head samples of patients with early FHN were collected during total hip arthroplasty (THA), high-field 7.0T MRI scans were performed in vitro, and the average T2 values were calculated. Cartilage samples were obtained from the weight-bearing area (FHN group) and non-weight-bearing area (Control group), divided into 3 equal parts and used for biochemical analysis, histopathological staining, and gene expression analysis...
December 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29208412/impact-of-the-surface-charge-of-polydiacetylene-micelles-on-their-interaction-with-human-innate-immune-protein-c1q-and-the-complement-system
#14
Nicole M Thielens, Agathe Belime, Edmond Gravel, Sarah Ancelet, Charlotte Caneiro, Eric Doris, Wai Li Ling
Polydiacetylene (pDA) micelles have been demonstrated to be effective drug carriers for cancer therapy in mouse model. However, little is known about their interaction with the human complement system, which constitutes an important part of the innate immune system and can cause severe hypersensitivity reactions. Herein, we investigate the influence of micelle surface charge on the binding of complement protein C1q, the target recognition unit that activates the classical complement pathway and performs a range of other important physiological functions...
December 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29207842/a-three-month-comparative-evaluation-of-the-effect-of-different-surface-treatment-agents-on-the-surface-integrity-and-softness-of-acrylic-based-soft-liner-an-in-vivo-study
#15
Harekrishna Jayendra Raval, Neerja Mahajan, Y G Naveen, Rajesh Sethuraman
Introduction: Acrylic based soft liners are cost effective, yet are inferior in durability as compared to silicone based liners. Hence, this study was conducted to evaluate if the softness and surface integrity of acrylic based soft liner can be maintained by using different surface treatment agents. Aim: To comparatively evaluate the effects of Varnish, Monopoly and Kregard surface treatment agents on the surface integrity and softness of acrylic based soft liner at baseline, at one month and after three months...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207203/a-rotaxane-scaffold-bearing-multiple-redox-centers-synthesis-surface-modification-and-electrochemical-properties
#16
Jean-Francois Nierengarten, Marie Steffenhagen, Alina Latus, Thi Minh Nguyet Trinh, Iwona Nierengarten, Ivan T Lucas, Suzanne Joiret, Jessem Landoulsi, Béatrice Delavaux-Nicot, Emmanuel Maisonhaute
A rotaxane scaffold incorporating two dithiolane anchoring units for the modification of gold surfaces has been functionalized with multiple copies of a redox unit, namely ferrocene. Surface modification has been first assessed at the single molecule level by atomic force microscopy (AFM) and scanning tunneling microscopy (STM) imaging, while tip enhanced Raman spectroscopy (TERS) provided the local vibrational signature of the ferrocenyl subunits of the rotaxanes grafted onto the gold surface. Finally, oxidation of the redox moieties within a rotaxane scaffold grafted onto gold microelectrodes has been investigated by ultrafast cyclic voltammetry...
December 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29207071/hepatocellular-carcinoma-targeted-nanoparticles-for-cancer-therapy
#17
Chien-Hsun Wu, Chun-Hsin Lan, Kuan-Lin Wu, Yao-Ming Wu, Wann-Neng Jane, Michael Hsiao, Han-Chung Wu
Nanocarriers, such as liposomes, have the potential to increase the payload of chemotherapeutic drugs while decreasing toxicity to non-target tissues; such advantageous properties can be further enhanced through surface conjugation of nanocarriers with targeting moieties. We previously reported that SP94 peptides, identified by phage display, exhibited higher binding affinity to human hepatocellular carcinoma (HCC) than to hepatocytes and other normal cells. Here, we confirm the tumor-targeting properties of SP94 peptide by near-infrared fluorescence imaging...
November 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29206154/application-of-a-saddle-type-eddy-current-sensor-in-steel-ball-surface-defect-inspection
#18
Huayu Zhang, Mingming Zhong, Fengqin Xie, Maoyong Cao
Steel ball surface-defect inspection was performed by using a new saddle-type eddy current sensor (SECS), which included a saddle coil and a signal conditioning circuit. The saddle coil was directly wound on the steel ball's outer bracket in a semi-circumferential direction. Driven by a friction wheel, the test steel ball rotated in a one-dimensional direction, such that the steel ball surface was fully scanned by the SECS. There were two purposes for using the SECS in the steel ball inspection system: one was to reduce the complexity of the unfolding wheel of the surface deployment mechanism, and the other was to reduce the difficulty of sensor processing and installation...
December 5, 2017: Sensors
https://www.readbyqxmd.com/read/29205175/anomalous-water-dynamics-at-surfaces-and-interfaces-synergistic-effects-of-confinement-and-surface-interactions
#19
Rajib Biswas, Biman Bagchi
In nature, water is often found in contact with surfaces that are extended on the scale of molecule size but small on a macroscopic scale. Examples include lipid bilayers and reverse micelles as well as biomolecules like proteins, DNA and zeolites, to name a few. While the presence of surfaces and interfaces interrupts the continuous hydrogen bond network of liquid water, confinement on a mesoscopic scale introduces new features. Even when extended on a molecular scale, natural and biological surfaces often have features (like charge, hydrophobicity) that vary on the scale of the molecular diameter of water...
December 5, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29205059/5tr1-aptamer-pegylated-liposomal-doxorubicin-enhances-cellular-uptake-and-suppresses-tumour-growth-by-targeting-muc1-on-the-surface-of-cancer-cells
#20
Seyedeh Alia Moosavian, Khalil Abnous, Javad Akhtari, Leila Arabi, Ali Gholamzade Dewin, Mahmoudreza Jafari
Employing targeting ligands with high affinity to tumour receptors is an important strategy to increase treatment efficacy. The use of aptamers as targeting agent is increasingly prevalent in drug delivery systems. Mucin1 (MUC1) is a glycoprotein that is over-expressed on the surface of several cancer cells and plays an important role in metastasis and invasion. 5TR1-aptamer is a DNA aptamer, which targets MUC1 receptors. The present study investigated the anti-tumour activity and therapeutic effectiveness of 5TR1-aptamer-PEGylated liposomal doxorubicin (PLD) delivery system in C26 tumour-bearing mice...
December 5, 2017: Artificial Cells, Nanomedicine, and Biotechnology
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