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https://www.readbyqxmd.com/read/28765071/ficz-generates-human-tdcs-that-induce-cd4-cd25-high-foxp3-treg-like-cell-differentiation
#1
Brenda B Jurado-Manzano, Daniel Zavala-Reyes, Edgar A Turrubiartes-Martínez, Diana P Portales-Pérez, Roberto González-Amaro, Esther Layseca-Espinosa
Dendritic cells (DCs) play a central role in the maintenance of immune homeostasis, their participation as professional antigen presenting cells is essential to the initiation of the adaptive immune response as well as to the induction of tolerance. The recently described role of the aryl hydrocarbon receptor (AhR) in the immune system, particularly in the modulation of the adaptive immune response has attracted the attention as a potential player in the induction of immune tolerance. However, the effects of AhR activation through endogenous ligands on human DCs have been poorly evaluated...
July 29, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28762907/-subpopulation-composition-of-cd4-t-lymphocytes-as-factor-contributing-to-the-progression-of-atherosclerosis-of-carotid-arteries
#2
A Yu Filatova, E A Pylaeva, A V Potekhina, A K Osokina, O A Pogorelova, M I Tripoten, T V Balakhonova, S I Provatorov, E A Noeva, E A Klesareva, O I Afanasieva, T I Arefieva
AIM: to assess prognostic significance of blood content of regulatory and effector T-lymphocytes for progression of atherosclerosis (AS) of carotid arteries. MATERIAL AND METHODS: We enrolled in this study 33 men with various severity of carotid AS. Carotid artery duplex scan was done at admission and in 1 year after enrollment. AS progression was defined as appearance of novel stenosis in common or internal carotid artery or more or equal 5% increase of preexisting stenosis...
April 2017: Kardiologiia
https://www.readbyqxmd.com/read/28720146/analysis-of-long-term-cd4-cd25highcd127-t-reg-cells-kinetics-in-peripheral-blood-of-lung-transplant-recipients
#3
Davide Piloni, Monica Morosini, Sara Magni, Alice Balderacchi, Luigia Scudeller, Emanuela Cova, Tiberio Oggionni, Giulia Stella, Carmine Tinelli, Filippo Antonacci, Andrea Maria D'Armini, Federica Meloni
BACKGROUND: The role of CD4(+)CD25(high)CD127(-) T-reg cells in solid-organ Transplant (Tx) acceptance has been extensively studied. In previous studies on kidney and liver recipients, peripheral T-reg cell counts were associated to graft survival, while in lung Tx, there is limited evidence for similar findings. This study aims to analyze long term peripheral kinetics of T-reg-cells in a cohort of lung recipients and tests its association to several clinical variables. METHODS: From jan 2009 to dec 2014, 137 lung Tx recipients were submitted to an immunological follow up (median: 105...
July 18, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28670318/cigarette-smoke-increases-cd8%C3%AE-dendritic-cells-in-an-ovalbumin-induced-airway-inflammation
#4
Thayse Regina Brüggemann, Paula Fernandes, Luana de Mendonça Oliveira, Maria Notomi Sato, Mílton de Arruda Martins, Fernanda Magalhães Arantes-Costa
Asthma is an allergic lung disease and, when associated to cigarette smoke exposition, some patients show controversial signs about lung function and other inflammatory mediators. Epidemiologic and experimental studies have shown both increasing and decreasing inflammation in lungs of subjects with asthma and exposed to cigarette smoke. Therefore, in this study, we analyzed how cigarette smoke affects pro-inflammatory and anti-inflammatory mediators in a murine model of allergic pulmonary inflammation. We sensitized Balb/c mice to ovalbumin (OVA) with two intraperitoneal injections...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28655574/cisplatin-along-with-herbal-drug-treatment-reduces-the-percentage-of-regulatory-t-cells-and-decreased-the-severity-of-experimental-visceral-leishmaniasis
#5
Heena Sachdeva, Sukhbir Kaur
BACKGROUND: Visceral leishmaniasis is the most alarming and devastating amongst the various forms of leishmaniases. It is caused by Leishmania donovani, an obligate intracellular parasite of macrophages that survives through immunosuppression. Absence of T regulatory cells provides complete clearance of the parasite. A few immunoprophylactics have been sought to battle instinctive leishmaniasis, with fluctuating achievement. Our previous studies have shown that treatment of L. donovani infected mice with cisplatin along with herbal drugs resulted in decreased parasite load with heightened delayed type hypersensitivity responses (DTH), increased levels of IgG2a, IFN-γ, IL-2, CD4+ cells, NK 1...
June 8, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28648851/the-influence-of-mild-acidity-on-lysyl-phosphatidylglycerol-biosynthesis-and-lipid-membrane-physico-chemical-properties-in-methicillin-resistant-staphylococcus-aureus
#6
Reg P Rehal, Helene Marbach, Alasdair T M Hubbard, Anam A Sacranie, Federica Sebastiani, Giovanna Fragneto, Richard D Harvey
The increased biosynthesis of lysyl-phosphatidylglycerol in Staphylococcus aureus when cultured under conditions of mild acidity and the resultant increased proportion of this lipid in the plasma membrane of the bacterium, alters the physico-chemical properties of lipid bilayers in a manner which is itself dependent upon environmental pH. Clinically relevant strains of S. aureus, both methicillin susceptible and resistant, all exhibited increased lysyl-phosphatidylglycerol biosynthesis in response to mild environmental acidity, albeit to differing degrees, from ∼30% to ∼55% total phospholipid...
August 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28599462/detection-of-tax-specific-ctls-in-lymph-nodes-of-adult-t-cell-leukemia-lymphoma-patients-and-its-association-with-foxp3-positivity-of-regulatory-t-cell-function
#7
Ayako Ichikawa, Hiroaki Miyoshi, Fumiko Arakawa, Junichi Kiyasu, Kensaku Sato, Daisuke Niino, Yoshizo Kimura, Maki Yoshida, Riko Kawano, Hiroko Muta, Yasuo Sugita, Koichi Ohshima
Human T-cell lymphotropic virus type (HTLV)-1 Tax is a viral protein that has been reported to be important in the proliferation of adult T-cell leukemia/lymphoma (ATLL) cells and to be a target of HTLV-1-specific cytotoxic T lymphocytes (CTLs). However, it is not clear how Tax-specific CTLs behave in lymph nodes of ATLL patients. The present study analyzed the immunostaining of Tax-specific CTLs. Furthermore, ATLL tumor cells are known to be positive for forkhead box P3 (Foxp3)and to have a regulatory T (Treg)-cell-like function...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28594573/activation-of-integrated-stress-response-and-metabolic-dysfunction-in-a-murine-model-of-sleep-apnea
#8
Abdelnaby Khalyfa, Zhuanhong Qiao, Alex Gileles-Hillel, Ahamed A Khalyfa, Mahzad Akbarpour, Brian Popko, David Gozal
BACKGROUND: Intermittent hypoxia (IH) induces activation of the integrated stress response (ISR), but its role in IH-induced visceral white adipose tissue (vWAT) insulin resistance in unknown. CHOP is activated by chronic ISR, while GADD34 dephosphorylates the subunit of translation initiation factor 2 (eIF2α), leading to termination of ISR. We hypothesized that CHOP/Gadd34 null mice would not manifest evidence of insulin resistance following IH exposures. METHODS: 8-week-old CHOP/GADD34-/- (DM) and wild type (WT) littermates were randomly assigned to IH or RA exposures for 6 weeks...
June 8, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28590550/osi-027-modulates-acute-graft-versus-host-disease-after-liver-transplantation-in-a-rat-model
#9
Xiao Zhi, Fei Xue, Wei Chen, Chao Liang, Hao Liu, Tao Ma, Xuefeng Xia, Liqiang Hu, Xueli Bai, Tingbo Liang
Despite its rarity (1%-2%), acute graft-versus-host disease after liver transplantation (LTx-aGVHD) has a high mortality rate (85%). A gradual decrease in regulatory T cells (T-regs) correlates with disease progression in a rat LTx-GVHD model and treatments which increase T-regs exert therapeutic effects on LTx-aGVHD. In this study, LTx-aGVHD model rats were treated with rapamycin (RAPA), OSI-027 or an equal quantity of vehicle. Rats treated with OSI-027 survived longer (>100 days) than those in the RAPA (70±8 days) or control (24±3 days) groups...
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28588755/role-of-pro-and-anti-inflammatory-phenomena-in-the-physiopathology-of-type-2-diabetes-and-obesity
#10
REVIEW
Luciano Pirola, José Candido Ferraz
In obesity, persistent low-grade inflammation is considered as a major contributor towards the progression to insulin resistance and type 2 diabetes while in lean subjects the immune environment is non-inflammatory. Massive adipose tissue (AT) infiltration by pro-inflammatory M1 macrophages and several T cell subsets as obesity develops leads to the accumulation - both in the AT and systemically - of numerous pro-inflammatory cytokines, including interleukin-1β (IL-1β), tumor necrosis factor α, IL-17 and IL-6 which are strongly associated with the progression of the obese phenotype towards the metabolic syndrome...
May 26, 2017: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28571991/short-communication-use-of-fecal-starch-concentration-as-an-indicator-of-dry-feed-digestion-in-preweaned-dairy-calves
#11
T S Dennis, W Hu, F X Suarez-Mena, T M Hill, J D Quigley, R L Schlotterbeck
Fecal starch (FS) has been used as a tool to evaluate starch and diet digestibility in lactating dairy cows and feedlot steers. Some on-farm advisors also use FS to evaluate calf starter digestibility in preweaned dairy calves. Our objective was to evaluate the influence of starter intake (SI), starch and organic matter digestibility, milk replacer (MR) feeding rate, and age on FS concentrations in preweaned dairy calves. Male Holstein calves (43 ± 2.9 kg of body weight; n = 35) from a single farm were fed different amounts of MR ranging from 0...
May 29, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28524239/oral-contraceptive-pills-risky-or-protective-in-case-of-trichinella-spiralis-infection
#12
M A Hasby Saad, D A Radi, E A Hasby
The aim of this study was to investigate how Trichinella spiralis infection can be affected by contraceptive pills in vivo. Methods included six groups of female Wistar rats; healthy, Trichinella infected, receiving combined contraceptive pills (COCPs), receiving progestin only pills (POPs), infected receiving COCPs and infected receiving POPs. Parasite burden was measured; adult worm counts, gravidity, larvae and reproductive capacity index). Histopathological examination, immunohistochemical detection of C-kit+ mast cells and Foxp3+ T-reg...
May 19, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28507062/interleukin-4-promotes-the-development-of-ex-foxp3-th2-cells-during-immunity-to-intestinal-helminths
#13
Victoria S Pelly, Stephanie M Coomes, Yashaswini Kannan, Manolis Gialitakis, Lewis J Entwistle, Jimena Perez-Lloret, Stephanie Czieso, Isobel S Okoye, Dominik Rückerl, Judith E Allen, Frank Brombacher, Mark S Wilson
Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4(+)Foxp3(+) regulatory T cells (T reg cells) impedes protective responses, resulting in chronic infections. The ratio between T reg and effector T cells can therefore determine the outcome of infection. The redifferentiation of T reg cells into Th cells has been identified in hyperinflammatory diseases. In this study, we asked whether ex-T reg Th2 cells develop and contribute to type-2 immunity...
June 5, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28502136/cd4-cd25-cd127low-regulatory-t-cells-as-indicator-of-rheumatoid-arthritis-disease-activity
#14
Sahar S Khattab, Amany M El-Saied, Rehab A Mohammed, Eman E Mohamed
Rheumatoid arthritis (RA) is an autoimmune disease characterized by disturbed immune regulation, inducing a progressive cartilage and bone destruction. Despite enrichment of T regulatory cell (T-regs) in synovial fluid, conflicting results are reported concerning T-regs in peripheral blood (PB) of RA patients. To determine possible correlation between the frequency of PB CD4+ CD25+CD127low (T-regs) with RA disease activity. Forty females with RA, classified according to the Disease Activity Score 28 (DAS-28), as highly active, mild-moderate or low disease activity; and 20 age and sex matched healthy controls, were enrolled to study CD4+ CD25+ CD127low T- regs in PB by flow cytometry...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28457204/assessing-cognitive-representations-of-antidepressants-development-and-validation-of-the-attitudes-toward-medication-depression-inventory
#15
Bonnie M Hagerty, Reg A Williams, James Aikens, Melissa A Bathish, Brady T West, Douglas S Fuller, Joe Kazemi
Antidepressant drugs represent the mainstay of treatment for depression; however, nonadherence is a major problem. Attitudes are predictors of long-term adherence and drive medication use. The Attitudes Toward Medication-Depression (ATM-D) Inventory was developed and tested with 131 patients in primary care settings who reported a diagnosis of depression. Content validity was assessed by experts with a 94.4% agreement on item relevancy. Exploratory factor analysis showed three factors (course of medication treatment, identity, and control) that accounted for 57% of the total variance in the final 17-item scale...
April 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28362433/il-2-prevents-deletion-of-developing-t-regulatory-cells-in-the-thymus
#16
Daniel Y Hu, Rushika C Wirasinha, Christopher C Goodnow, Stephen R Daley
In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8- CCR7+ Helios+ thymocytes poised to upregulate Foxp3. The deletion prevented by IL-2 signalling is Foxp3 independent and occurs later in thymocyte development than the deletion that is prevented by Card11 signalling. Our results distinguish two bottlenecks at which strongly self-reactive thymocytes undergo deletion or progress to the next stage of T-reg differentiation; Card11 regulates the first bottleneck and IL-2 regulates the second...
June 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28351463/tuberculin-skin-test-and-interferon-gamma-release-assay-use-among-privately-insured-persons-in-the-united-states
#17
K Owusu-Edusei, E L Stockbridge, C A Winston, M Kolasa, R Miramontes
OBJECTIVE: To describe tuberculin skin test (TST) and interferon-gamma release assay (IGRA) (i.e., QuantiFERON®-TB [QFT] and T-SPOT®.TB [T-SPOT]) use among privately insured persons in the United States over a 15-year period. METHODS: We used current procedural terminology (CPT) codes for the TST and IGRAs to extract out-patient claims (2000-2014) and determined usage (claims/100 000). The χ2 test for trend in proportions was used to describe usage trends for select periods...
June 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28332200/immunoregulation-of-inflammatory-and-inhibitory-cytokines-by-vitamin-d3-in-patients-with-inflammatory-bowel-diseases
#18
REVIEW
H Alhassan Mohammed, A Mirshafiey, H Vahedi, G Hemmasi, A Moussavi Nasl Khameneh, K Parastouei, A A Saboor-Yaraghi
Inflammatory bowel disease (IBD) is a group of idiopathic, chronic and relapsing inflammatory conditions of the gastrointestinal tract, caused by an aberrant and exaggerated immunological response in the gut. Supplementation of vitamin D3 in patients with IBD exerts both direct and indirect regulatory roles on the naïve T cells, thereby maintaining a balance between inflammatory and inhibitory cytokines. The direct actions of vitamin D3 on naïve T cells result in the proliferation of more regulatory T cells and inhibitory cytokines such as IL-4, IL-10 and IL-5...
June 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28316421/immunophenotyping-of-blood-mononuclear-cells-from-p-berghei-nk-65-infected-and-immunized-balb-c-mice
#19
Vineet Kumar, Aruna Rakha, Ruchika Saroa, Upma Bagai
The present study demonstrates the alterations in the frequencies of helper, cytotoxic and suppressor T cells in blood of P. berghei infected and TPA immunized rodent host towards the induction of protective immune response. Statistically significant (p < 0.005) number of CD4(+) T cells was recorded on D9 [Post Challenge (PC)] meanwhile CD4(+) Treg cells were found to be declined in immunized mice as compared to infected. This increase in frequencies of T helper cells points towards the stimulation of strong Th2 immune response in immunized mice...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28293742/the-accumulation-of-regulatory-t-cells-in-the-hepatic-hilar-lymph-nodes-in-biliary-atresia
#20
Naoya Sakamoto, Toshihiro Muraji, Haruo Ohtani, Kouji Masumoto
PURPOSE: A proposed etiopathogenesis of biliary atresia (BA) involves T-cell-mediated inflammatory bile duct damage and progressive hepatic fibrosis. Pediatric surgeons often observe swelling of the hepatic hilar lymph nodes during the Kasai procedure. Given the importance of regulatory mechanisms in immune responses, the present study was designed to analyze the quantitative changes of regulatory T cells (T reg cells) in the hepatic hilar lymph nodes (hepatic hilar LNs) and peripheral blood (PB) in BA...
March 14, 2017: Surgery Today
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