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https://www.readbyqxmd.com/read/29133602/cardiovascular-outcomes-and-safety-of-empagliflozin-in-patients-with-type-2-diabetes-mellitus-and-peripheral-artery-disease-a-subanalysis-of-empa-reg-outcome
#1
Subodh Verma, C David Mazer, Mohammed Al-Omran, Silvio E Inzucchi, David Fitchett, Uwe Hehnke, Jyothis T George, Bernard Zinman
Peripheral artery disease (PAD) is one of the most common cardiovascular complications in patients with type 2 diabetes mellitus (T2DM)(1) and is a predictor of cardiovascular death.(2) Interventions that reduce cardiovascular complications in this patient population are urgently required. In the EMPA-REG OUTCOME trial, the sodium glucose cotransporter 2 inhibitor empagliflozin reduced the risk of cardiovascular death by 38% (hazard ratio [HR], 0.62; 95% confidence interval [CI] 0.49-0.77]) and hospitalization for heart failure (HHF) by 35% (HR, 0...
November 13, 2017: Circulation
https://www.readbyqxmd.com/read/29120583/role-of-lymphocyte-subpopulations-in-the-immunopathogenesis-of-psoriasis-and-the-effect-of-narrow-band-uvb-phototherapy-on-the-immunological-profile-of-psoriasis-patients
#2
Mona Fattouh, Asmaa N El-Din, Mohammed A El-Hamd
Psoriasis is one of the most common chronic, inflammatory, T-cell-mediated autoimmune diseases. Narrow-band UVB (NB-UVB) therapy is widely used in the treatment of psoriasis; however, its mechanism of action is still not well understood. The objective of this study was to investigate the circulating T-lymphocyte subpopulations in psoriasis patients before and after NB-UVB, to get insights into the mechanism of NB-UVB in the treatment of psoriasis. The severity of psoriasis was assessed by means of the Psoriasis Area and Severity Index (PASI-score)...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29066577/identification-and-characterization-of-t-reg-like-cells-in-zebrafish
#3
Melissa Kasheta, Corrie A Painter, Finola E Moore, Riadh Lobbardi, Alysia Bryll, Eli Freiman, David Stachura, Arlin B Rogers, Yariv Houvras, David M Langenau, Craig J Ceol
Regulatory T (T reg) cells are a specialized sublineage of T lymphocytes that suppress autoreactive T cells. Functional studies of T reg cells in vitro have defined multiple suppression mechanisms, and studies of T reg-deficient humans and mice have made clear the important role that these cells play in preventing autoimmunity. However, many questions remain about how T reg cells act in vivo. Specifically, it is not clear which suppression mechanisms are most important, where T reg cells act, and how they get there...
October 24, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29038367/a-nonimmune-function-of-t-cells-in-promoting-lung-tumor-progression
#4
Jesse A Green, Nicholas Arpaia, Michail Schizas, Anton Dobrin, Alexander Y Rudensky
The involvement of effector T cells and regulatory T (T reg) cells in opposing and promoting solid organ carcinogenesis, respectively, is viewed as a shifting balance between a breach versus establishment of tolerance to tumor or self-antigens. We considered that tumor-associated T cells might promote malignancy via distinct mechanisms used by T cells in nonlymphoid organs to assist in their maintenance upon injury or stress. Recent studies suggest that T reg cells can participate in tissue repair in a manner separable from their immunosuppressive capacity...
October 16, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29037917/immunomodulation-after-radiofrequency-ablation-of-locally-advanced-pancreatic-cancer-by-monitoring-the-immune-response-in-10-patients
#5
Alessandro Giardino, Giulio Innamorati, Stefano Ugel, Omar Perbellini, Roberto Girelli, Isabella Frigerio, Paolo Regi, Filippo Scopelliti, Giovanni Butturini, Salvatore Paiella, Matilde Bacchion, Claudio Bassi
OBJECTIVE/BACKGROUND: RFA of pancreatic cancer has been demonstrated to be feasible and safe with a positive impact on survival. The aim was to investigate whether an immune reaction is activated after locally advanced pancreatic cancer (LAPC) ablation. METHODS: Peripheral Blood samples were obtained preoperatively and on post-operative days 3-30. Evaluated parameters were: cells [CD4(+), CD8(+) and activated subsets, T-Reg, Monocytes, myeloid and plasmocytoid Dendritic cells (mDC and pDC)] and cytokines [Interleukin (IL)-6, Stromal-cells derived factor (SDF)-1, IL-1β, Tumour-Necrosis Factor (TNF)-α, Interferon (IFN)-γ, Vascular Endothelial Growth Factor (VEGF), chemokine (C-C motif) ligand 5 (CCL-5), Transforming-Growth Factor (TGF)-β]...
September 27, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29020355/effects-of-empagliflozin-on-risk-for-cardiovascular-death-and-heart-failure-hospitalization-across-the-spectrum-of-heart-failure-risk-in-the-empa-reg-outcome%C3%A2-trial
#6
David Fitchett, Javed Butler, Philippe van de Borne, Bernard Zinman, John M Lachin, Christoph Wanner, Hans J Woerle, Stefan Hantel, Jyothis T George, Odd Erik Johansen, Silvio E Inzucchi
Aims: Empagliflozin reduced the risk of cardiovascular (CV) death and heart failure (HF) hospitalizations in patients with type 2 diabetes (T2D) and established CV disease (CVD) in the EMPA-REG OUTCOME® trial. We investigated whether the benefit of empagliflozin was observed across the spectrum of HF risk. Methods and results: Seven thousand and twenty patients with T2D (HbA1c 7-10% and eGFR > 30 mL/min/1.73 m2) were treated with empagliflozin 10 or 25 mg, or placebo once daily and followed for median 3...
August 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28989221/deformable-3d-2d-registration-for-guiding-k-wire-placement-in-pelvic-trauma-surgery
#7
J Goerres, M Jacobson, A Uneri, T De Silva, M Ketcha, S Reaungamornrat, S Vogt, G Kleinszig, J-P Wolinsky, G Osgood, J H Siewerdsen
Pelvic Kirschner wire (K-wire) insertion is a challenging surgical task requiring interpretation of complex 3D anatomical shape from 2D projections (fluoroscopy) and delivery of device trajectories within fairly narrow bone corridors in proximity to adjacent nerves and vessels. Over long trajectories (~10-25 cm), K-wires tend to curve (deform), making conventional rigid navigation inaccurate at the tip location. A system is presented that provides accurate 3D localization and guidance of rigid or deformable surgical devices ("components" - e...
March 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28986471/international-multicentre-validation-of-the-arteriovenous-malformation-related-intracerebral-haemorrhage-avich-score
#8
Marian C Neidert, Michael T Lawton, Louis J Kim, John D Nerva, Kaoru Kurisu, Fusao Ikawa, Juergen Konczalla, Nazife Dinc, Volker Seifert, Julian Habdank-Kolaczkowski, Taketo Hatano, Makoto Hayase, Dino Podlesek, Gabriele Schackert, Thomas Wanet, Sven Gläsker, Christoph J Griessenauer, Christopher S Ogilvy, Andreas Kneist, Ulrich Sure, Burkhardt Seifert, Luca Regli, Oliver Bozinov, Jan-Karl Burkhardt
OBJECTIVE: The recently published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better outcome prediction for patients with arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH scores. Here we present the results of a multicentre, external validation of the AVICH score. METHODS: All participating centres (n=11) provided anonymous data on 325 patients to form the Spetzler-Martin (SM) grade, the supplemented SM (sSM) grade, the ICH score and the AVICH score...
October 6, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28975891/local-immune-response-in-cutaneous-basal-cell-carcinoma
#9
Silje Haukali Omland
BCC is an immunogenic tumor highlighted by the increased risk in immunosuppressed individuals and the frequent occurrence of tumor infiltrating lymphocytes (TILs) in the tumor surroundings. Immunotherapy is evolving as a promising treatment strategy for several cancer types where topical immunostimulators are among the possibilities for superficial BCC. The overall aim of this thesis is to characterize the immunologic response upon BCC as well as characterizing the surrounding tumor stroma. The aim was achieved by the use of a variety of laboratory techniques; immunohistochemistry, immunoflourescence, qRT-PCR and NGS...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28954490/decreased-nk-cell-activity-after-partial-vulvectomy-in-pregnant-patient-with-vulvar-intraepithelial-neoplasia-3-vin3
#10
Malgorzata Jerzak, Andrzej Nowakowski, Monika Ohams, Andrzej Górski, Włodzimierz Baranowsk
INTRODUCTION AND OBJECTIVE: The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3). MATERIAL AND METHODS: NK cell and T reg activity in the study patient were analysed using flow cytometry. RESULTS: Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome. CONCLUSIONS: Although vulvar cancer may influence immune cell activity, this issue merits further study...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28954091/beh%C3%A3-et-s-disease-review-with-emphasis-on-dermatological-aspects
#11
REVIEW
Maria Antonieta Rios Scherrer, Vanessa Barreto Rocha, Lucas Campos Garcia
Behçet's disease is a systemic vasculitis characterized by attacks of acute inflammation, which can affect almost every vascularized area of the body. There is a close correlation between the geographical distribution of HLA-B51 and its prevalence. In the etiopathogenesis there are indications of genetic susceptibility associated with environmental influence. Among the involved genes are those that encompass innate and adaptive immunities. Polymorphisms and epistatic interactions in several genes are described, as well as the presence of imbalance lineage between HLA-B51 and A (MICA)...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28939166/spinal-cord-mri-signal-changes-at-one-year-after-cervical-decompression-surgery-is-useful-for-predicting-mid-term-clinical-outcome-an-observational-study-using-propensity-scores
#12
Shota Ikegami, Jun Takahashi, Hiromichi Misawa, Takahiro Tsutsumimoto, Mutsuki Yui, Shugo Kuraishi, Toshimasa Futatsugi, Masashi Uehara, Hiroki Oba, Hiroyuki Kato
BACKGROUND CONTEXT: There is little information on the relationship between magnetic resonance imaging (MRI) T2-weighted high signal change (T2HSC) in the spinal cord and surgical outcome for cervical myelopathy. We therefore examined whether T2HSC regression at one year postoperatively reflected 5-year prognosis after adjustment using propensity scores for potential confounding variables, which have been a disadvantage of earlier observational studies. PURPOSE: Clarify the usefulness of MRI signal changes for the prediction of mid-term surgical outcome in cervical myelopathy patients...
September 19, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28904068/empagliflozin-and-clinical-outcomes-in-patients-with-type-2-diabetes-established-cardiovascular-disease-and-chronic-kidney-disease
#13
Christoph Wanner, John M Lachin, Silvio E Inzucchi, David Fitchett, Michaela Mattheus, Jyothis T George, Hans-Juergen Woerle, Uli C Broedl, Maximilian von Eynatten, Bernard Zinman
Background -Empagliflozin, a sodium glucose cotransporter 2 inhibitor, reduced cardiovascular morbidity and mortality in patients with type 2 diabetes and established cardiovascular disease in the EMPA-REG OUTCOME(®) trial. Urinary glucose excretion with empagliflozin decreases with declining renal function, resulting in less potency for glucose lowering in patients with kidney disease. We investigated the effects of empagliflozin on clinical outcomes in patients with type 2 diabetes, established cardiovascular disease and chronic kidney disease...
September 13, 2017: Circulation
https://www.readbyqxmd.com/read/28879170/helicobacter-pylori-caga-is-associated-with-milder-duodenal-histological-changes-in-chilean-celiac-patients
#14
Yalda Lucero, Amaya Oyarzún, Miguel O'Ryan, Rodrigo Quera, Nelly Espinosa, Romina Valenzuela, Daniela Simian, Elisa Alcalde, Claudio Arce, Mauricio J Farfán, Alejandra F Vergara, Iván Gajardo, Jocelyn Mendez, Jorge Carrasco, Germán Errázuriz, Mónica Gonzalez, Juan C Ossa, Eduardo Maiza, Francisco Perez-Bravo, Magdalena Castro, Magdalena Araya
HIGHLIGHTS What is already known about this subject?Celiac disease (CD) has a high clinical and histological diversity and the mechanisms underlying this phenomenon remain elusive.H. pylori is a bacterium that chronically infect gastric and duodenal mucosa activating both a Th1/Th17 and T-reg pathways.The role of H. pylori (and the effect of their virulence factors) in CD have not yet completely elucidated.What are the new findings?cagA+ H. pylori strains are associated to milder histological damage in infected CD patients...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28839507/comparison-of-immune-responses-in-pigs-infected-with-chinese-highly-pathogenic-prrs-virus-strain-hv-and-north-american-strain-nadc-20
#15
X Li, A Galliher-Beckley, L Wang, J Nietfeld, W Feng, J Shi
INTRODUCTION: Chinese HP-PRRSV characterized by high morbidity and mortality of all ages of pigs emerged since 2006 in China. The immune response of HP-PRRSV was never compared with conventional low pathogenic PRRSV strain. OBJECTIVE: In this study, we compared the immune responses elicited by a Chinese HP-PRRSV strain HV and a North American RRSV strain NADC20 infections. RESULT: Pigs infected with NADC-20 showed significantly higher Ab titers than HV-PRRSV infected pigs at 9 DPI...
2017: Open Virology Journal
https://www.readbyqxmd.com/read/28836359/the-potential-role-and-rationale-for-treatment-of-heart-failure-with-sodium-glucose-co-transporter-2-inhibitors
#16
REVIEW
Javed Butler, Carine E Hamo, Gerasimos Filippatos, Stuart J Pocock, Richard A Bernstein, Martina Brueckmann, Alfred K Cheung, Jyothis T George, Jennifer B Green, James L Januzzi, Sanjay Kaul, Carolyn S P Lam, Gregory Y H Lip, Nikolaus Marx, Peter A McCullough, Cyrus R Mehta, Piotr Ponikowski, Julio Rosenstock, Naveed Sattar, Afshin Salsali, Benjamin M Scirica, Sanjiv J Shah, Hiroyuki Tsutsui, Subodh Verma, Christoph Wanner, Hans-Juergan Woerle, Faiez Zannad, Stefan D Anker
Heart failure (HF) and type 2 diabetes mellitus (T2DM) are both growing public health concerns contributing to major medical and economic burdens to society. T2DM increases the risk of HF, frequently occurs concomitantly with HF, and worsens the prognosis of HF. Several anti-hyperglycaemic medications have been associated with a concern for worse HF outcomes. More recently, the results of the EMPA-REG OUTCOME trial showed that the sodium-glucose co-transporter 2 (SGLT2) inhibitor empagliflozin was associated with a pronounced and precocious 38% reduction in cardiovascular mortality in subjects with T2DM and established cardiovascular disease [Correction added on 8 September 2017, after first online publication: "32%" in the previous sentence was corrected to "38%"]...
August 24, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28830910/redefining-thymus-medulla-specialization-for-central-tolerance
#17
Emilie J Cosway, Beth Lucas, Kieran D James, Sonia M Parnell, Manuela Carvalho-Gaspar, Andrea J White, Alexei V Tumanov, William E Jenkinson, Graham Anderson
During αβT cell development, the thymus medulla represents an essential microenvironment for T cell tolerance. This functional specialization is attributed to its typical organized topology consisting of a branching structure that contains medullary thymic epithelial cell (mTEC) networks to support negative selection and Foxp3(+) T-regulatory cell (T-reg) development. Here, by performing TEC-specific deletion of the thymus medulla regulator lymphotoxin β receptor (LTβR), we show that thymic tolerance mechanisms operate independently of LTβR-mediated mTEC development and organization...
November 6, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28807036/t-time-a-data-repository-of-t-cell-and-calcium-release-activated-calcium-channel-activation-imagery
#18
Cody Arbuckle, Milton Greenberg, Adrienne Bergh, Rene German, Nick Sirago, Erik Linstead
BACKGROUND: A fundamental understanding of live-cell dynamics is necessary in order to advance scientific techniques and personalized medicine. For this understanding to be possible, image processing techniques, probes, tracking algorithms and many other methodologies must be improved. Currently there are no large open-source datasets containing live-cell imaging to act as a standard for the community. As a result, researchers cannot evaluate their methodologies on an independent benchmark or leverage such a dataset to formulate scientific questions...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28765071/ficz-generates-human-tdcs-that-induce-cd4-cd25-high-foxp3-treg-like-cell-differentiation
#19
Brenda B Jurado-Manzano, Daniel Zavala-Reyes, Edgar A Turrubiartes-Martínez, Diana P Portales-Pérez, Roberto González-Amaro, Esther Layseca-Espinosa
Dendritic cells (DCs) play a central role in the maintenance of immune homeostasis, their participation as professional antigen presenting cells is essential to the initiation of the adaptive immune response as well as to the induction of tolerance. The recently described role of the aryl hydrocarbon receptor (AhR) in the immune system, particularly in the modulation of the adaptive immune response has attracted the attention as a potential player in the induction of immune tolerance. However, the effects of AhR activation through endogenous ligands on human DCs have been poorly evaluated...
July 29, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28762907/-subpopulation-composition-of-cd4-t-lymphocytes-as-factor-contributing-to-the-progression-of-atherosclerosis-of-carotid-arteries
#20
A Yu Filatova, E A Pylaeva, A V Potekhina, A K Osokina, O A Pogorelova, M I Tripoten, T V Balakhonova, S I Provatorov, E A Noeva, E A Klesareva, O I Afanasieva, T I Arefieva
AIM: to assess prognostic significance of blood content of regulatory and effector T-lymphocytes for progression of atherosclerosis (AS) of carotid arteries. MATERIAL AND METHODS: We enrolled in this study 33 men with various severity of carotid AS. Carotid artery duplex scan was done at admission and in 1 year after enrollment. AS progression was defined as appearance of novel stenosis in common or internal carotid artery or more or equal 5% increase of preexisting stenosis...
April 2017: Kardiologiia
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