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https://www.readbyqxmd.com/read/28343355/anti-c1q-autoantibodies-as-markers-of-renal-involvement-in-childhood-onset-systemic-lupus-erythematosus
#1
Cécile Picard, Jean-Christophe Lega, Bruno Ranchin, Pierre Cochat, Natalia Cabrera, Nicole Fabien, Alexandre Belot
BACKGROUND: Childhood-onset systemic lupus erythematosus (cSLE) is rare, and considered more severe than its adult-onset counterpart. Lupus nephritis (LN) occurs more frequently in children, accounting for higher long-term morbidity and mortality compared with adults. Thus, reliable biological markers are needed to predict disease course. This study aimed to investigate the capacity of anti-C1q autoantibodies (Abs) to predict renal flare and global disease activity in cSLE patients, and association with disease activity and kidney involvement...
March 25, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28343349/modernizing-quality-of-life-assessment-development-of-a-multidimensional-computerized-adaptive-questionnaire-for-patients-with-schizophrenia
#2
Pierre Michel, Karine Baumstarck, Christophe Lancon, Badih Ghattas, Anderson Loundou, Pascal Auquier, Laurent Boyer
OBJECTIVE: Quality of life (QoL) is still assessed using paper-based and fixed-length questionnaires, which is one reason why QoL measurements have not been routinely implemented in clinical practice. Providing new QoL measures that combine computer technology with modern measurement theory may enhance their clinical use. The aim of this study was to develop a QoL multidimensional computerized adaptive test (MCAT), the SQoL-MCAT, from the fixed-length SQoL questionnaire for patients with schizophrenia...
March 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28343348/process-analytical-techniques-for-hot-melt-extrusion-and-their-application-to-amorphous-solid-dispersions
#3
REVIEW
Patrick Hitzer, Tim Bäuerle, Tobias Drieschner, Edwin Ostertag, Katharina Paulsen, Holger van Lishaut, Günter Lorenz, Karsten Rebner
Newly developed active pharmaceutical ingredients (APIs) are often poorly soluble in water. As a result the bioavailability of the API in the human body is reduced. One approach to overcome this restriction is the formulation of amorphous solid dispersions (ASDs), e.g., by hot-melt extrusion (HME). Thus, the poorly soluble crystalline form of the API is transferred into a more soluble amorphous form. To reach this aim in HME, the APIs are embedded in a polymer matrix. The resulting amorphous solid dispersions may contain small amounts of residual crystallinity and have the tendency to recrystallize...
March 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28343347/bioanalysis-of-farnesyl-pyrophosphate-in-human-plasma-by-high-performance-liquid-chromatography-coupled-to-triple-quadrupole-tandem-mass-spectrometry-and-hybrid-quadrupole-orbitrap-high-resolution-mass-spectrometry
#4
Hiroshi Sugimoto, Mie Iguchi, Fumihiro Jinno
The isoprenoids farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) are pivotal intermediates for cholesterol homeostasis and cell signaling in the mevalonate pathway. We developed a sensitive and selective high-performance liquid chromatography tandem triple quadrupole mass spectrometry (LC-QQQ-MS) method for FPP in human plasma without the need for a derivatization process. We optimized the sample preparation procedure to extract FPP and (13)C5-FPP (as internal standard) from sample fluids using methanol...
March 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28343341/public-availability-of-research-data-in-dentistry-journals-indexed-in-journal-citation-reports
#5
Antonio Vidal-Infer, Beatriz Tarazona, Adolfo Alonso-Arroyo, Rafael Aleixandre-Benavent
OBJECTIVES: Dentistry is a medical discipline with an increasing scientific production in the last years. Due to the importance of data sharing in science, this study aims at analyzing the availability of raw data in articles from scientific journals indexed in the Dentistry category of the 2014 edition of the Journal Citation Reports. MATERIAL AND METHODS: A review of the 88 websites of journals from the Dentistry category was conducted to determine the data-sharing editorial policies...
March 26, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28343337/trismus-following-different-treatment-modalities-for-head-and-neck-cancer-a-systematic-review-of-subjective-measures
#6
REVIEW
Sook Y Loh, Robert W J Mcleod, Hassan A Elhassan
The aim of this review was to compare systematically the subjective measure of trismus between different interventions to treat head and neck cancer, particularly those of the oropharynx. Using The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) Guidelines, Six databases were searched for the text using various terms which include "oropharyngeal/head and neck cancer", "trismus/mouth opening" and the various treatment modalities. Included in the review were clinical studies (> or =10 patients)...
March 25, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28343333/use-of-phase-locking-value-in-sensorimotor-rhythm-based-brain-computer-interface-zero-phase-coupling-and-effects-of-spatial-filters
#7
Wenjuan Jian, Minyou Chen, Dennis J McFarland
Phase-locking value (PLV) is a potentially useful feature in sensorimotor rhythm-based brain-computer interface (BCI). However, volume conduction may cause spurious zero-phase coupling between two EEG signals and it is not clear whether PLV effects are independent of spectral amplitude. Volume conduction might be reduced by spatial filtering, but it is uncertain what impact this might have on PLV. Therefore, the goal of this study was to explore whether zero-phase PLV is meaningful and how it is affected by spatial filtering...
March 25, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28343290/muscle-injury-after-intramuscular-administration-of-diclofenac-a-case-report-supported-by-magnetic-resonance-imaging
#8
Mareike Probst, Jens-Peter Kühn, Christiane Modeß, Eberhard Scheuch, Anne Seidlitz, Norbert Hosten, Werner Siegmund, Werner Weitschies
Intramuscular injection of diclofenac is still frequently practiced, although there is ample evidence that the risk of local tissue intolerability is highly underestimated. The aim of this study was to evaluate local toxicity in a patient using magnetic resonance imaging. A patient who gave written informed consent received a medically indicated intramuscular administration of diclofenac 75 mg/2 mL. Simultaneously with magnetic resonance imaging of the depot, a clinical-chemical evaluation and quantification of diclofenac in plasma was performed...
December 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/28343203/developing-the-professional-competence-of-future-doctors-in-the-instructional-setting-of-higher-medical-educational-institutions
#9
Halyna Yu Morokhovets, Yuliia V Lysanets
INTRODUCTION: The main objectives of higher medical education is the continuous professional improvement of physicians to meet the needs dictated by the modern world both at undergraduate and postgraduate levels. In this respect, the system of higher medical education has undergone certain changes - from determining the range of professional competences to the adoption of new standards of education in medicine. AIM: The article aims to analyze the parameters of doctor's professionalism in the context of competence-based approach and to develop practical recommendations for the improvement of instruction techniques...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28343196/-hope-as-psychological-resource-for-nurturant-professionals-medicine-case-study
#10
Наталия Е Водопьянова, Вера А Чикер, Валерия В Потявина
INTRODUCTION: In the article, the issues concerning hope, which is one of the most important resources for specialists of many nurturant professions, are observed. The theoretical analysis of hope and its categorization from the perspective of subjective and resource-based view is given. The special scientific and practical interest to human subjective and personal resources is determined by their unique role not only in human life support, but also in overcoming hard situations and extreme obstacles, including crisis situations in professional activity, with the example of the profession of a doctor...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28343166/development-and-validation-of-a-yoga-module-for-parkinson-disease
#11
Noopur Kakde, Kashinath G Metri, Shivarama Varambally, Raghuram Nagaratna, H R Nagendra
Background Parkinson's disease (PD), a progressive neurodegenerative disease, affects motor and nonmotor functions, leading to severe debility and poor quality of life. Studies have reported the beneficial role of yoga in alleviating the symptoms of PD; however, a validated yoga module for PD is unavailable. This study developed and validated an integrated yoga module(IYM) for PD. Methods The IYM was prepared after a thorough review of classical yoga texts and previous findings. Twenty experienced yoga experts, who fulfilled the inclusion criteria, were selected validating the content of the IYM...
March 25, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28343165/student-directed-video-validation-of-psychomotor-skills-performance-a-strategy-to-facilitate-deliberate-practice-peer-review-and-team-skill-sets
#12
Gregory A DeBourgh, Susan K Prion
Background Essential nursing skills for safe practice are not limited to technical skills, but include abilities for determining salience among clinical data within dynamic practice environments, demonstrating clinical judgment and reasoning, problem-solving abilities, and teamwork competence. Effective instructional methods are needed to prepare new nurses for entry-to-practice in contemporary healthcare settings. Method This mixed-methods descriptive study explored self-reported perceptions of a process to self-record videos for psychomotor skill performance evaluation in a convenience sample of 102 pre-licensure students...
March 22, 2017: International Journal of Nursing Education Scholarship
https://www.readbyqxmd.com/read/28343164/a-quantitative-concordance-measure-for-comparing-and-combining-treatment-selection-markers
#13
Zhiwei Zhang, Shujie Ma, Lei Nie, Guoxing Soon
Motivated by an HIV example, we consider how to compare and combine treatment selection markers, which are essential to the notion of precision medicine. The current literature on precision medicine is focused on evaluating and optimizing treatment regimes, which can be obtained by dichotomizing treatment selection markers. In practice, treatment decisions are based not only on efficacy but also on safety, cost and individual preference, making it difficult to choose a single cutoff value for all patients in all settings...
March 25, 2017: International Journal of Biostatistics
https://www.readbyqxmd.com/read/28343147/ethical-ramifications-of-the-paolo-macchiarini-case
#14
Jaime A Teixeira da Silva
The Paolo Macchiarini case has several ethical ramifications. Professor Macchiarini, formerly of the Karolinska Institutet (KI), became famous for the tracheal surgeries he conducted between 2008 and 2014. His rapid rise to fame was followed by an almost equally rapid fall from grace as official reports, articles in newspapers and television programmes revealed several aspects related to misconduct in his curriculum vitae, professional practices and publishing-related activity. Formal misconduct reports issued by four KI co-workers in late 2014, then again in 2016, coupled with social scandals, including the tricking of a famous US television newscaster into a false marriage, a previous arrest in Italy for apparent bribery, and acute narcissism, all tainted Macchiarini's legend...
March 15, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28343146/antimicrobial-effect-of-the-biotronic%C3%A2-top3-supplement-and-efficacy-in-protecting-rainbow-trout-oncorhynchus-mykiss-from-infection-by-aeromonas-salmonicida-subsp-salmonicida
#15
Simon Menanteau-Ledouble, Ines Krauss, Rui Alexandre Goncalves, Barbara Weber, Gonçalo Abreu Santos, Mansour El-Matbouli
Demand for more environmentally friendly practices have led to the adoption of several feed supplements by the fish farming industry. In the present study, we investigated a commercially available formula that includes a mixture of three compounds: organic acids, a phytochemical and Biomin® Permeabilizing Complex. This mixture demonstrated antimicrobial properties in vitro and was able to inhibit growth of multiple species of aquatic bacterial pathogens, including Aeromonas salmonicida. Bacterial challenge was performed using A...
March 18, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28343128/peroxy-titanium-complex-based-inks-for-low-temperature-compliant-anatase-thin-films
#16
N S Shabanov, A Sh Asvarov, A Chiolerio, K Sh Rabadanov, A B Isaev, F F Orudzhev, S Sh Makhmudov
Stable highly crystalline titanium dioxide colloids are of paramount importance for the establishment of a solution-processable library of materials that could help in bringing the advantages of digital printing to the world of photocatalysis and solar energy conversion. Nano-sized titanium dioxide in the anatase phase was synthesized by means of hydrothermal methods and treated with hydrogen peroxide to form Peroxy-Titanium Complexes (PTCs). The influence of hydrogen peroxide on the structural, optical and rheological properties of titanium dioxide and its colloidal solutions were assessed and a practical demonstration of a low temperature compliant digitally printed anatase thin film given...
March 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28343123/estimation-of-red-light-running-frequency-using-high-resolution-traffic-and-signal-data
#17
Peng Chen, Guizhen Yu, Xinkai Wu, Yilong Ren, Yueguang Li
Red-light-running (RLR) emerges as a major cause that may lead to intersection-related crashes and endanger intersection safety. To reduce RLR violations, it's critical to identify the influential factors associated with RLR and estimate RLR frequency. Without resorting to video camera recordings, this study investigates this important issue by utilizing high-resolution traffic and signal event data collected from loop detectors at five intersections on Trunk Highway 55, Minneapolis, MN. First, a simple method is proposed to identify RLR by fully utilizing the information obtained from stop bar detectors, downstream entrance detectors and advance detectors...
March 23, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28343111/the-intimate-relationship-as-a-site-of-social-protection-partnerships-between-people-who-inject-drugs
#18
Tim Rhodes, Jake Rance, Suzanne Fraser, Carla Treloar
Public health research treats intimate partnerships as sites of risk management, including in the management of HIV and hepatitis C transmission. This risk-infused biomedical approach tends to undermine appreciation of the emotional and socially situated meanings of care in intimate partnerships. In this article we explore qualitative interview accounts of the care enacted in partnerships between people who inject drugs, drawing on a 2014 study of 34 couples and 12 individuals living in two locations of Australia...
March 10, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28343050/photocatalytic-efficiency-of-fe2o3-tio2-for-the-degradation-of-typical-dyes-in-textile-industries-effects-of-calcination-temperature-and-uv-assisted-thermal-synthesis
#19
Mohsen Nasirian, Ciro Fernando Bustillo-Lecompte, Mehrab Mehrvar
The inadequate management practices in industrial textile effluents have a considerable negative impact on the environment and human health due to the indiscriminate release of dyes. Photocatalysis is one of the diverse advance oxidation processes (AOPs) and titanium dioxide (TiO2) is recognized for its high oxidation and reduction power. A composite photocatalyst of Fe2O3/TiO2 is synthesized using different mass ratios of Fe:TiO2 to improve its photoactivity. The composite photocatalyst is calcined at 300-900 °C...
March 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28343045/cervical-disc-arthroplasty-do-conflicts-of-interest-influence-the-outcome-of-clinical-studies
#20
REVIEW
Ankur S Narain, Fady Y Hijji, Kelly H Yom, Krishna T Kudaravalli, Kern Singh
BACKGROUND CONTEXT: Cervical disc arthroplasty (CDA) is an emerging technique for the treatment of cervical degenerative disease. Multiple studies have investigated the outcomes of CDA, particularly in comparison to cervical arthrodesis techniques such as anterior cervical discectomy and fusion (ACDF). As many entities have financial interests in CDA implants, it is imperative to consider the influence of conflicts of interest on the results of studies investigating the efficacy of CDA...
March 22, 2017: Spine Journal: Official Journal of the North American Spine Society
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