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https://www.readbyqxmd.com/read/29763648/autism-spectrum-disorder-classification-diagnosis-and-therapy
#1
REVIEW
Samata R Sharma, Xenia Gonda, Frank I Tarazi
Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS). The new diagnostic criteria of ASD focuses on two core domains: social communication impairment and restricted interests/repetitive behaviors. The prevalence of ASD has been steadily increasing over the past two decades, with current estimates reaching up to 1 in 36 children. Hereditary factors, parental history of psychiatric disorders, pre-term births, and fetal exposure to psychotropic drugs or insecticides have all been linked to higher risk of ASD...
May 12, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29758375/alterations-in-the-microstructure-of-white-matter-in-children-and-adolescents-with-tourette-syndrome-measured-using-tract-based-spatial-statistics-and-probabilistic-tractography
#2
Hilmar P Sigurdsson, Sophia E Pépés, Georgina M Jackson, Amelia Draper, Paul S Morgan, Stephen R Jackson
Tourette syndrome (TS) is a neurodevelopmental disorder characterised by repetitive and intermittent motor and vocal tics. TS is thought to reflect fronto-striatal dysfunction and the aetiology of the disorder has been linked to widespread alterations in the functional and structural integrity of the brain. The aim of this study was to assess white matter (WM) abnormalities in a large sample of young patients with TS in comparison to a sample of matched typically developing control individuals (CS) using diffusion MRI...
April 12, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29755921/a-comprehensive-review-of-tourette-syndrome-and-complementary-alternative-medicine
#3
REVIEW
Ashutosh Kumar, L Duda, G Mainali, S Asghar, D Byler
Purpose of Review: Tourette syndrome (TS) is a neuropsychiatric condition defined by both motor and phonic tics over a period of at least 1 year with the onset before 18 years of age. The purpose of this article is to review the use of complementary alternative medicine (CAM) in children and adults with Tourette syndrome with emphasis on recent research. Recent Findings: Most patients do not tell their physician about the use of CAM unless if specifically asked...
2018: Current Developmental Disorders Reports
https://www.readbyqxmd.com/read/29748952/disentangling-tourette-syndrome-heterogeneity-through-hierarchical-ascendant-clustering
#4
Elena Cravedi, Emmanuelle Deniau, Marianna Giannitelli, Hugues Pellerin, Virginie Czernecki, Tiphanie Priou, Jean Xavier, Angèle Consoli, Andreas Hartmann, David Cohen
AIM: To explore the heterogeneity of Tourette syndrome as part of a neurodevelopmental spectrum. METHOD: Using hierarchical ascendant clustering based on tic symptoms, developmental milestones, and neurodevelopmental comorbidities, we analyzed the heterogeneity of Tourette syndrome phenotypes in a sample of 174 children and adolescents with Tourette syndrome referred to a tertiary university clinic. RESULTS: The model yielded three distinct clusters characterized as follows...
May 10, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29746399/tourette-syndrome-clinical-spectrum-mechanisms-and-personalized-treatments
#5
Andreas Hartmann, Yulia Worbe
PURPOSE OF REVIEW: To describe recent advances regarding the disease spectrum in Tourette syndrome, offer new mechanistic insights into tic generation and provide clues for personalized treatments in this disorder. RECENT FINDINGS: Apart from tics, which define Tourette syndrome, comorbidities are the rule and not the exception. They significantly define clinical presentation, disease severity and quality of life. Recent studies have highlighted the importance of screening for depression, anxiety and autism spectrum disorders in Tourette syndrome...
May 8, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29736078/deep-brain-stimulation-of-anteromedial-globus-pallidus-internus-for-severe-tourette-syndrome
#6
Paresh K Doshi, Raghvendra Ramdasi, Smita Thorve
Tourette syndrome (TS) is a complex disorder characterized by tics and is associated with behavioral problems. Although its intensity decreases in adolescence and adult life, in some cases it continues to remain severe and refractory to medical treatment. Deep brain stimulation has been offered as a treatment option in such cases. We report two cases of TS treated with of anteromedial globus pallidum internus. Both the cases had good postoperative control of tics and associated obsessive-compulsive behavior...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29735930/efficacy-of-a-gluten-free-diet-in-the-gilles-de-la-tourette-syndrome-a-pilot-study
#7
Luis Rodrigo, Nuria Álvarez, Enrique Fernández-Bustillo, Javier Salas-Puig, Marcos Huerta, Carlos Hernández-Lahoz
The Gilles de la Tourette syndrome (GTS) and Non-Coeliac Gluten Sensitivity (NCGS) may be associated. We analyse the efficacy of a gluten-free diet (GFD) in 29 patients with GTS (23 children; six adults) in a prospective pilot study. All of them followed a GFD for one year. The Yale Global Tics Severity Scale (YGTSS), the Yale-Brown Obsessive-Compulsive Scale—Self Report (Y-BOCS) or the Children’s Yale-Brown Obsessive-Compulsive Scale—Self Report (CY-BOCS), and the Cavanna’s Quality of Life Questionnaire applied to GTS (GTS-QOL) were compared before and after the GFD; 74% of children and 50% of adults were males, not significant (NS)...
May 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29735110/psychiatric-treatment-and-management-of-psychiatric-comorbidities-of-movement-disorders
#8
Kelda Harris Walsh, Katherine Soe, Shivali Sarawgi
Pediatric movement disorders may present with psychiatric symptoms at many points during the course of the disease. For the relatively common pediatric movement disorder, Tourette syndrome, psychiatric comorbidities are well-described and treatment is well-studied. Managing these comorbidities may be more effective than improving the movements themselves. For more uncommon movement disorders, such as juvenile-onset Huntington disease, treatment of psychiatric comorbidities is not well-characterized, and best-practice recommendations are not available...
April 2018: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29729555/self-esteem-in-adults-with-tourette-syndrome-and-chronic-tic-disorders-the-roles-of-tic-severity-treatment-and-comorbidity
#9
Hilary Weingarden, Lawrence Scahill, Susanne Hoeppner, Alan L Peterson, Douglas W Woods, John T Walkup, John Piacentini, Sabine Wilhelm
BACKGROUND: Tourette syndrome (TS) and chronic tic disorders (CTD) are stigmatizing disorders that may significantly impact self-esteem. Alternatively, comorbid psychiatric illnesses may affect self-esteem more than tics themselves. Extant research on self-esteem in TS/CTD is limited, has inconsistently examined the effect of comorbidities on self-esteem, and yields mixed findings. METHOD: This study aimed to clarify the roles of tics versus comorbid diagnoses on self-esteem in a large, carefully diagnosed sample of adults with TS/CTD (N = 122) receiving 10 weeks of Comprehensive Behavioral Intervention for Tics (CBIT) or Psychoeducation and Supportive Therapy (PST)...
April 23, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29723733/positive-clinical-effects-of-gamma-knife-capsulotomy-in-a-patient-with-deep-brain-stimulation-refractory-tourette-syndrome-and-obsessive-compulsive-disorder
#10
Raphaëlle Richieri, Graham Blackman, Richard Musil, Giorgio Spatola, Andrea E Cavanna, Christophe Lançon, Jean Régis
We report the first case of a patient with severe, intractable Tourette Syndrome with comorbid Obsessive Compulsive disorder, who recovered from both disorders with gamma-knife (GK) stereotactic radiosurgery following deep brain stimulation (DBS). This case highlights the possible role of the internal capsule within the neural circuitries underlying both TS and OCD, and suggests that in cases of treatment-refractory TS and comorbid OCD, bilateral anterior capsulotomy using stereotactic radiosurgery may be a viable treatment option...
April 26, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29707998/quality-of-life-among-children-and-adolescents-with-tourette-disorder-and-comorbid-adhd-a-clinical-controlled-study
#11
Seda Erbilgin Gün, Ayse Kilincaslan
OBJECTIVE: To examine (a) the quality of life (QOL) in children with Tourette's disorder (TD) and ADHD (TD + ADHD) compared with ADHD without tics (ADHD alone) and (b) the effects of the severity of tics, ADHD symptoms, comorbid diagnoses, and family functioning on QOL. METHOD: The assessments included the Kiddie-Schedule for Affective Disorders and Schizophrenia, Yale Global Tic Severity Scale, ADHD Rating Scale, Pediatric Quality of Life Inventory, and Family Assessment Device...
April 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29704964/the-long-term-effects-of-group-based-psychological-interventions-for-children-with-tourette-syndrome-a-randomized-controlled-trial
#12
Julia Dabrowski, John King, Katie Edwards, Rachel Yates, Isobel Heyman, Sharon Zimmerman-Brenner, Tara Murphy
This randomized controlled trial examined the long-term effects of group-based psychological interventions on measures of tic severity, self-reported quality of life (QOL), and school attendance. Children (n = 28) with Tourette syndrome (TS) were assessed 12 months after completing a course of either group-based Habit Reversal Training (HRT) or Education. Both groups demonstrated long-term improvement in tic severity and QOL, which included significant continued improvement during the follow-up (FU) period...
May 2018: Behavior Therapy
https://www.readbyqxmd.com/read/29698507/altered-dopaminergic-regulation-of-the-dorsal-striatum-is-able-to-induce-tic-like-movements-in-juvenile-rats
#13
Ester Nespoli, Francesca Rizzo, Tobias Boeckers, Ulrike Schulze, Bastian Hengerer
Motor tics are sudden, repetitive, involuntary movements representing the hallmark behaviors of the neurodevelopmental disease Tourette's syndrome (TS). The primary cause of TS remains unclear. The initial observation that dopaminergic antagonists alleviate tics led to the development of a dopaminergic theory of TS etiology which is supported by post mortem and in vivo studies indicating that non-physiological activation of the striatum could generate tics. The striatum controls movement execution through the balanced activity of dopamine receptor D1 and D2-expressing medium spiny neurons of the direct and indirect pathway, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29690990/-movement-disorders-in-children-and-adolescents
#14
Asli Sena Kücükyildiz, Nanette Mol Debes, Liselotte Skov
Tourette syndrome, obsessive-compulsive disorder, ticlike compulsions and motoric stereotypies are all movement disorders, which start in childhood and can be difficult to differentiate. In this article, we have outlined the most important focus points on how to differentiate the conditions in order to diagnose correctly and in order to refer to proper treatment.
April 16, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29680144/-including-recovery-in-the-care-pathway-after-cancer
#15
Catherine Tourette-Turgis, Joseph Gligorov, Cynthia Fleury, Jean-François Pelletier
The period after cancer treatments have finished requires personalised services and support, based on the theoretical and clinical concept of recovery. The recovery phase comprises several dimensions: it is not because a patient is in remission or declared medically cured that he or she has recovered.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29676780/retrospective-evaluation-of-a-restrictive-transfusion-strategy-in-older-adults-with-hip-fracture
#16
Lorene Zerah, Lucile Dourthe, Judith Cohen-Bittan, Marc Verny, Mathieu Raux, Anthony Mézière, Frédéric Khiami, Cendrine Tourette, Christian Neri, Yannick Le Manach, Bruno Riou, Hélène Vallet, Jacques Boddaert
OBJECTIVES: To compare the association between a restrictive transfusion strategy and cardiovascular complications during hospitalization for hip fracture with the association between a liberal transfusion strategy and cardiovascular complications, accounting for all transfusions from the emergency department to postacute rehabilitation settings. DESIGN: Retrospective study. SETTING: Perioperative geriatric care unit. PARTICIPANTS: All individuals aged 70 and older admitted to the emergency department for hip fracture and hospitalized in our perioperative geriatric care unit (N=667; n=193 in the liberal transfusion group, n=474 in the restrictive transfusion group) from July 2009 to April 2016...
April 20, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29676713/-deep-brain-stimulation-for-psychiatric-disorders
#17
M Figee, P R Schuurman, D Denys
- Deep brain stimulation (DBS) corrects pathological activity of neuropsychiatric brain networks with high frequency current via implanted brain electrodes.- DBS is an effective and safe treatment for therapy-refractory obsessive-compulsive disorder and potentially also for therapy-refractory major depressive disorder.- Experimental psychiatric indications for DBS are Tourette syndrome, addiction, anorexia nervosa, post-traumatic stress disorder, autism and schizophrenia.- DBS influences brain networks that are relevant for a variety of psychiatric symptoms...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29675956/clonidine-modulates-the-activity-of-the-subthalamic-supplementary-motor-loop-evidence-from-a-pharmacological-study-combining-dbs-and-eeg-recordings-in-parkinsonian-patients
#18
Charlotte Spay, Marion Albares, Guillaume Lio, Stephane Thobois, Emmanuel Broussolle, Brian Lau, Benedicte Ballanger, Philippe Boulinguez
Clonidine is an anti-hypertensive medication which acts as an alpha-adrenergic receptors agonist. As the noradrenergic system is likely to support cognitive functions including attention and executive control, other clinical uses of clonidine have recently gained popularity for the treatment of neuropsychiatric disorders like attention-deficit hyperactivity disorder or Tourette syndrome, but the mechanism of action is still unclear. Here, we test the hypothesis that the noradrenergic system regulates the activity of subthalamo-motor cortical loops, and that this influence can be modulated by clonidine...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29656800/dopaminergic-disturbances-in-tourette-syndrome-an-integrative-account
#19
REVIEW
Tiago V Maia, Vasco A Conceição
Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters that cause low tonic but high phasic dopamine, 3) presynaptic dysfunction in dopamine neurons, or 4) dopaminergic hyperinnervation. We review evidence that contradicts the first two hypotheses; we also note that the last two hypotheses have traditionally been considered too narrowly, explaining only small subsets of findings...
March 9, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29656001/-fl%C3%A3-neur-neurologique-in-paris-a-guide-to-pinpointing-the-houses-of-famous-neurologists-in-the-late-xix-century
#20
REVIEW
Hélio Afonso Ghizoni Teive, Francisco Manoel Branco Germiniani, Carlos Henrique Ferreira Camargo, Olivier Walusinski, Andrew J Lees
INTRODUCTION: During the last quarter of the XIX century, Paris, France, particularly the Salpêtrière Hospital was the most important centre of reference of Clinical Neurology in the world. The group based on the Salpêtrière Hospital, led by Professor Charcot, who was arguably the most celebrated neurologist in Europe. OBJECTIVE: In this historical review, we present and locate the addresses of the houses of these famous Parisian neurologists from the late XIX century...
April 11, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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