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JOURNAL ARTICLE
Meryem Khadija Talbo, Alexandra Katz, Michel Dostie, Laurent Legault, Anne-Sophie Brazeau
BACKGROUND: Low socioeconomic status (SES) may add to the challenges of type 1 diabetes (T1D) management and be an independent risk factor for chronic and acute diabetes complications. Our aim in this study was to evaluate the association between SES and TID management and risk of complications in a universal health-care system using data from a registry of people living with T1D (PWT1D) in Québec, Canada (the BETTER registry). METHODS: This study was a cross-sectional analysis describing the association between SES factors (education, income, employment and insurance coverage) and T1D outcomes (glycated hemoglobin [A1C], acute and chronic complications and comorbidities), using chi-square tests and regression analyses (adjusted for diabetes duration, sex, ethnicity and diabetes technology use)...
March 3, 2022: Canadian Journal of Diabetes
#22
JOURNAL ARTICLE
Eda Cinar, Dana Anaby, Rosalie Dostie, Chantal Camden
AIMS: The purpose of this Phase II study is to identify the perceived strengths and weaknesses of a collaborative tiered school-based physiotherapy (PT) service delivery model, considering its core attributes and tiered interventions identified in the first phase of the study (Phase I), and explore the potential facilitators and barriers to implementing the model internationally. METHODS: Three focus group discussions were conducted with international experts (n = 16) Discussions focused on the core attributes and tiered interventions of the model in Phase I...
2022: Physical & Occupational Therapy in Pediatrics
#23
REVIEW
Rosalie Dostie, Isabelle Gaboury, Eda Cinar, Chantal Camden
AIMS: The purpose of this scoping review was to explore the available literature and identify gaps regarding the acceptability of telerehabilitation interventions provided by pediatric physical therapists and occupational therapists. METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-ScR) framework to guide this scoping review. We systematically searched eight scholarly databases (CINAHL, Medline, SPORTDiscus, AMED, APA PsychInfo, SCOPUS, PEDro, OTseeker), five gray literature databases (MedlinePlus, Gray Literature Report, OpenGrey, National Institute for Health, ProQuest Dissertation & Theses Global [PQDT]), conducted a manual search of selected references and contacted international experts...
2022: Physical & Occupational Therapy in Pediatrics
#24
MULTICENTER STUDY
Marie-Pierre Cyr, Rosalie Dostie, Chantal Camden, Chantale Dumoulin, Paul Bessette, Annick Pina, Walter Henry Gotlieb, Korine Lapointe-Milot, Marie-Hélène Mayrand, Mélanie Morin
BACKGROUND: A large proportion of gynecological cancer survivors suffer from pain during sexual intercourse, also known as dyspareunia. Following a multimodal pelvic floor physical therapy (PFPT) treatment, a reduction in pain and improvement in psychosexual outcomes were found in the short term, but no study thus far has examined whether these changes are sustained over time. PURPOSE: To examine the improvements in pain, sexual functioning, sexual distress, body image concerns, pain anxiety, pain catastrophizing, painful intercourse self-efficacy, depressive symptoms and pelvic floor disorder symptoms in gynecological cancer survivors with dyspareunia after PFPT, and to explore women's perceptions of treatment effects at one-year follow-up...
2022: PloS One
#25
Sangam Shah, Rajeev Ojha, Sanjeeta Sitaula, Dosti Regmi, Ragesh Karn, Bikram Prasad Gajurel, Reema Rajbhandari, Niraj Gautam, Sunanda Paudel, Aashish Shrestha
Neuromyelitis optica spectrum disorder (NMOSD) is an immune-mediated inflammatory condition involving spinal cord and optic nerves. Diagnosis of NMOSD is done by aquaporin-4 antibody (AQP4) in patients with optic neuritis. Myelin oligodendrocyte glycoprotein (MOG) expressed on the oligodendrocyte cell surface and on the outermost cell surface of the myelin sheath may also be present in patients with NMOSD bilateral optic neuritis. Here, we describe a case of a thirty-nine-year-old-female with recurrent bilateral optic neuritis with positive anti-MOG antibody, and anti-MOG syndrome has not previously been reported from Nepal...
2021: Case Reports in Neurological Medicine
#26
JOURNAL ARTICLE
C Decuyper, M Brysbaert, M B Brodeur, A S Meyer
We present written naming norms from 153 young adult Dutch speakers for 1397 photographs (the BOSS set; see Brodeur, Dionne-Dostie, Montreuil, & Lepage, 2010; Brodeur, Guérard, & Bouras, 2014). From the norming study, we report the preferred (modal) name, alternative names, name agreement, and average object agreement. In addition, the data base includes Zipf frequency, word prevalence and Age of Acquisition for the modal picture names collected. Furthermore, we describe a subset of 359 photographs with very good name agreement and a subset of 35 photos with two common names...
2021: Journal of Cognition
#27
Livia P Carvalho, Simon Décary, Isabelle Beaulieu-Boire, Rosalie Dostie, Isabelle Lalonde, Émilie Texier, Laurence Laprise, Elizabeth Pepin, Mélodie Gilbert, Hélène Corriveau, Michel Tousignant
Many people living with Parkinson's Disease (PD) face issues with healthcare services, including delays in diagnosis and treatment, as well as limited access to specialized care, including rehabilitation programs. Non-motor and motor signs and symptoms typically observed in people with PD, such as tremor, rigidity, postural instability, bradykinesia, and freezing are particularly disabling and have been associated with falls, fractures, hospitalizations, and a worse quality of life. Baduanjin Qigong (BDJ) programs have been proven potentially effective in improving physical outcomes and reducing the incidence of falls in PD...
June 30, 2021: International Journal of Environmental Research and Public Health
#28
JOURNAL ARTICLE
Chantal Camden, Wenonah Campbell, Cheryl Missiuna, Jade Berbari, Léa Héguy, Cheyenne Gauvin, Rosalie Dostie, Lina Ianni, L Rivard, Dana Anaby
BACKGROUND.: The occupational therapy school-based Partnering for Change (P4C) model has mostly been documented in Ontario. PURPOSE.: This implementation study describes the implementation of P4C in two Québec elementary schools (P4C-Q), as well as therapy practices, their impacts, factors perceived to influence implementation, and recommendations. METHOD.: A sequential mixed-methods design was applied. Therapists (n=2) completed daily journals, describing activities by P4C-Q level...
March 2021: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
#29
JOURNAL ARTICLE
Christina M Nord, Tyler R Bonnell, Marcus J Dostie, S Peter Henzi, Louise Barrett
Muzzle contact, where one animal brings its muzzle into close proximity to that of another, has often been hypothesized as a straightforward means of socially mediated food investigation. Using 2,707 observations of muzzle contact occurring across 3 troops of wild vervet monkeys (Chlorocebus pygerythrus), we tested this social learning hypothesis. We first explored the social structuring of muzzle contact by analyzing the characteristics of initiators and receivers. Similar to previous research, juveniles initiated contact at higher rates than adults, particularly toward adult females and animals with lower dominance rankings...
February 22, 2021: Journal of Comparative Psychology
#30
REVIEW
Lawrence Faulkner, Marta Verna, Attilio Rovelli, Rajat Kumar Agarwal, Rakesh Dhanya, Lalith Parmar, Amit Sedai, Ankita Kumari, Stalin Ramprakash, C P Raghuram, Pallavi Mehta, Sandeep Elizabeth, Sadaf Khalid, Aliya Batool, Sarah Khan Ghilani, Itrat Fatima, Tatheer Zara, Priya Marwah, Rajpreet Soni, Deepa Trivedi, Valentino Conter, Marta Canesi, Dosti Othman, Vian Faeq, Katharina Kleinschmidt, Akif Yesillipek, Catherine G Lam, Scott C Howard, Selim Corbacioglu
Severe blood disorders and cancer are the leading cause of death and disability from noncommunicable diseases in the global pediatric population and a major financial burden. The most frequent of these conditions, namely sickle cell disease and severe thalassemia, are highly curable by blood or bone marrow transplantation (BMT) which can restore a normal health-related quality of life and be cost-effective. This position paper summarizes critical issues in extending global access to BMT based on ground experience in the start-up of several BMT units in middle-income countries (MICs) across South-East Asia and the Middle East where close to 700 allogeneic BMTs have been performed over a 10-year period...
March 2021: Bone Marrow Transplantation
#31
JOURNAL ARTICLE
Xue Qing David Wang, Christopher J F Cameron, Dana Segal, Denis Paquette, Mathieu Blanchette, Josée Dostie
Chromatin immunoprecipitation (ChIP) is used to probe the presence of proteins and/or their posttranslational modifications on genomic DNA. This method is often used alongside chromosome conformation capture approaches to obtain a better-rounded view of the functional relationship between chromatin architecture and its landscape. Since the inception of ChIP, its protocol has been modified to improve speed, sensitivity, and specificity. Combining ChIP with deep sequencing has recently improved its throughput and made genome-wide profiling possible...
2021: Methods in Molecular Biology
#32
JOURNAL ARTICLE
Jordan A Ramilowski, Chi Wai Yip, Saumya Agrawal, Jen-Chien Chang, Yari Ciani, Ivan V Kulakovskiy, Mickaël Mendez, Jasmine Li Ching Ooi, John F Ouyang, Nick Parkinson, Andreas Petri, Leonie Roos, Jessica Severin, Kayoko Yasuzawa, Imad Abugessaisa, Altuna Akalin, Ivan V Antonov, Erik Arner, Alessandro Bonetti, Hidemasa Bono, Beatrice Borsari, Frank Brombacher, Christopher JF Cameron, Carlo Vittorio Cannistraci, Ryan Cardenas, Melissa Cardon, Howard Chang, Josée Dostie, Luca Ducoli, Alexander Favorov, Alexandre Fort, Diego Garrido, Noa Gil, Juliette Gimenez, Reto Guler, Lusy Handoko, Jayson Harshbarger, Akira Hasegawa, Yuki Hasegawa, Kosuke Hashimoto, Norihito Hayatsu, Peter Heutink, Tetsuro Hirose, Eddie L Imada, Masayoshi Itoh, Bogumil Kaczkowski, Aditi Kanhere, Emily Kawabata, Hideya Kawaji, Tsugumi Kawashima, S Thomas Kelly, Miki Kojima, Naoto Kondo, Haruhiko Koseki, Tsukasa Kouno, Anton Kratz, Mariola Kurowska-Stolarska, Andrew Tae Jun Kwon, Jeffrey Leek, Andreas Lennartsson, Marina Lizio, Fernando López-Redondo, Joachim Luginbühl, Shiori Maeda, Vsevolod J Makeev, Luigi Marchionni, Yulia A Medvedeva, Aki Minoda, Ferenc Müller, Manuel Muñoz-Aguirre, Mitsuyoshi Murata, Hiromi Nishiyori, Kazuhiro R Nitta, Shuhei Noguchi, Yukihiko Noro, Ramil Nurtdinov, Yasushi Okazaki, Valerio Orlando, Denis Paquette, Callum J C Parr, Owen J L Rackham, Patrizia Rizzu, Diego Fernando Sánchez Martinez, Albin Sandelin, Pillay Sanjana, Colin A M Semple, Youtaro Shibayama, Divya M Sivaraman, Takahiro Suzuki, Suzannah C Szumowski, Michihira Tagami, Martin S Taylor, Chikashi Terao, Malte Thodberg, Supat Thongjuea, Vidisha Tripathi, Igor Ulitsky, Roberto Verardo, Ilya E Vorontsov, Chinatsu Yamamoto, Robert S Young, J Kenneth Baillie, Alistair R R Forrest, Roderic Guigó, Michael M Hoffman, Chung Chau Hon, Takeya Kasukawa, Sakari Kauppinen, Juha Kere, Boris Lenhard, Claudio Schneider, Harukazu Suzuki, Ken Yagi, Michiel J L de Hoon, Jay W Shin, Piero Carninci
Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways...
July 2020: Genome Research
#33
JOURNAL ARTICLE
Christopher J F Cameron, Xue Q D Wang, Josée Dostie, Mathieu Blanchette
OBJECTIVE: Ligation-Mediated Amplification (LMA) is a versatile biochemical tool for amplifying selected DNA sequences. LMA has increased in popularity due to its integration within chromosome conformation capture (5C) and chromatin immunoprecipitation (2C-ChIP) methodologies. The output of either 5C or 2C-ChIP protocols is a single-read sequencing library of ligated primer pairs that may or may not be multiplexed. While many computational tools currently exist for read mapping and analysis, these tools neither fully support multiplexed libraries nor provide qualitative reporting on the LMA primers involved...
June 3, 2020: BMC Research Notes
#34
JOURNAL ARTICLE
Masoumeh Rostami-Moez, Mohammad Rabiee-Yeganeh, Mohammadreza Shokouhi, Amin Dosti-Irani, Forouzan Rezapur-Shahkolai
BACKGROUND: Earthquakes are one of the most destructive natural disasters in which many people are injured, disabled, or died. Iran has only 1 % of the world's population, but the percentage of its earthquake-related deaths is absolutely higher. Therefore, this study aimed to determine the level of earthquake preparedness of households and its predictors using the Health Belief Model (HBM). METHODS: This observational descriptive and analytical study was conducted on 933 households in Hamadan province, located in the west of Iran, in 2019...
May 8, 2020: BMC Public Health
#35
JOURNAL ARTICLE
Kambiz Minaei, Zeinab Rashid, Leila Ramezani, Nooshin Zandi Sohani
Dendrothrips is one of 12 genera currently recognised in subfamily Dendrothripinae (ThripsWiki 2020). The species of Dendrothrips have the fore wing anteromarginal cilia arising ventrally behind the margin, but in contrast to species in other genera with this character state the wing apex is recurved without a terminal seta (Mound Tree 2016). Species of Dendrothrips breed on leaves, and many have been recorded from species of plant family Oleaceae (Marullo 2003). The species of Dendrothrips are recorded from Europe to Australia, including Africa and Asia...
February 26, 2020: Zootaxa
#36
JOURNAL ARTICLE
Identification of a C3'-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth.
Marc-Olivier Labbé, Laura Collins, Carole-Anne Lefebvre, Wael Maharsy, Janie Beauregard, Starr Dostie, Michel Prévost, Mona Nemer, Yvan Guindon
A synthetic strategy to access a novel family of nucleoside analogues bearing a C3'-nitrile substituted all-carbon quaternary center is presented herein. These purine bearing scaffolds were tested in two pancreatic cancer cell lines harboring either wild-type (BxPC3) or G12V KRAS (Capan2) mutations. A promising compound was shown to have significantly greater efficacy in the Capan2 cell line as compared to Gemcitabine, the clinical gold standard used to treat pancreatic cancer.
January 21, 2020: Bioorganic & Medicinal Chemistry Letters
#37
JOURNAL ARTICLE
Christopher Jf Cameron, Josée Dostie, Mathieu Blanchette
Hi-C is a popular technique to map three-dimensional chromosome conformation. In principle, Hi-C's resolution is only limited by the size of restriction fragments. However, insufficient sequencing depth forces researchers to artificially reduce the resolution of Hi-C matrices at a loss of biological interpretability. We present the Hi-C Interaction Frequency Inference (HIFI) algorithms that accurately estimate restriction-fragment resolution Hi-C matrices by exploiting dependencies between neighboring fragments...
January 14, 2020: Genome Biology
#38
JOURNAL ARTICLE
Christopher Young, Tyler R Bonnell, Leslie R Brown, Marcus J Dostie, Andre Ganswindt, Stefan Kienzle, Richard McFarland, S Peter Henzi, Louise Barrett
As the effects of global climate change become more apparent, animal species will become increasingly affected by extreme climate and its effect on the environment. There is a pressing need to understand animal physiological and behavioural responses to climatic stressors. We used the reactive scope model as a framework to investigate the influence of drought conditions on vervet monkey ( Chlorocebus pygerythrus ) behaviour, physiological stress and survival across 2.5 years in South Africa. Data were collected on climatic, environmental and behavioural variables and physiological stress via faecal glucocorticoid metabolites (fGCMs)...
November 2019: Royal Society Open Science
#39
JOURNAL ARTICLE
C Camden, R Dostie, L Heguy, C Gauvin, C Hudon, I Gaboury, L Rivard
BACKGROUND: Early identification of children at risk of developmental delay is crucial to promote healthy development. Assessing parental concerns about development is often part of identification processes. However, we currently do not understand well how and why parents become concerned, and, how and why they access early identification and intervention services. The purpose of this study was to explore parental perceptions about their child's development, and the factors influencing their reported professional help-seeking behaviours...
December 2, 2019: Child: Care, Health and Development
#40
JOURNAL ARTICLE
Tommy Lussier, Amarender Manchoju, Gang Wang, Starr Dostie, Scott Foster, Philippe Mochirian, Michel Prévost, Yvan Guindon
The synthesis of novel nucleoside analogues bearing a C3' all-carbon quaternary center and a C2'-hydroxy substituent is described. The all-carbon stereogenic center was generated through an intramolecular 7-endo attack of a silyl-tethered allyl moiety on a tertiary radical using photoredox catalysis. Subsequent allylic oxidation and diastereoselective hydride reductions provided the hydroxy substituent at C2', which then controls the stereoselective introduction of pyrimidine nucleobases on the corresponding furanose scaffold...
November 15, 2019: Journal of Organic Chemistry
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