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Diana Xin Hui Chan, Yilin Eileen Sim, Yiong Huak Chan, Ruban Poopalalingam, Hairil Rizal Abdullah
INTRODUCTION: Accurate surgical risk prediction is paramount in clinical shared decision making. Existing risk calculators have limited value in local practice due to lack of validation, complexities and inclusion of non-routine variables. OBJECTIVE: We aim to develop a simple, locally derived and validated surgical risk calculator predicting 30-day postsurgical mortality and need for intensive care unit (ICU) stay (>24 hours) based on routinely collected preoperative variables...
March 23, 2018: BMJ Open
Kazuo Yana, Hiroyuki Mino
This paper discusses a unified method based on the theory of point processes to characterize various types of bioelectric discrete signals such as heart beat timing, myoelectric activity, discharge of primary sensory neurons or neurons in the central nervous systems. The doubly stochastic point processes, in which the discrete event occurring intensity is stochastic, forms the most general class to characterize the discrete phenomena. In this paper the self-exciting process has been shown to be useful to characterize wide range of discrete biosignals...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Shlomit Yust-Katz, Dror Limon, Ramez Abu-Shkara, Tali Siegal
Neuro-oncology is a subspecialty attracting physicians from medical disciplines such as neurology, neurosurgery, pediatrics, oncology, and radiotherapy. It deals with diagnosis and management of primary brain tumors, as well as metastatic and non-metastatic neurological manifestations that frequently affect cancer patients including brain metastases, paraneoplastic syndromes and neurological complications of cancer treatment. A neuro-oncology unit was established in Davidoff Cancer Center at Rabin Medical Center...
August 2017: Harefuah
Daniele Santi, Giorgia Spaggiari, Livio Casarini, Flaminia Fanelli, Marco Mezzullo, Uberto Pagotto, Antonio R M Granata, Cesare Carani, Manuela Simoni
We present a case report of an atypical giant pituitary adenoma secreting follicle-stimulating hormone (FSH). A 55-year-old patient presented for erectile dysfunction, loss of libido and fatigue. The biochemical evaluation showed very high FSH serum levels in the presence of central hypogonadism. Neither testicular enlargement nor increased sperm count was observed, thus a secretion of FSH with reduced biological activity was supposed. The histological examination after neuro-surgery showed an atypical pituitary adenoma with FSH-positive cells...
June 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
E Bey, B Nicot, O Casez, L Le Normand
INTRODUCTION: Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. The aim of this review article was to discuss diagnostic and therapeutic options for these patients. SOURCES: A literature review of MedLine publications on urinary incontinence in normal pressure hydrocephalus was conducted. The following keywords were used: "hydrocephalus, normal pressure" and "bladder dysfunction" or "urinary incontinence" or "overactive bladder" or "urinary bladder, neurogenic"...
December 2016: Progrès en Urologie
Frank Tacke, Daniela C Kroy, Ana Paula Barreiros, Ulf P Neumann
Liver transplantation (LT) is a well-accepted procedure for end-stage liver disease in Germany. In 2015, 1489 patients were admitted to the waiting list (including 1308 new admissions), with the leading etiologies being fibrosis and cirrhosis (n = 349), alcoholic liver disease (n = 302), and hepatobiliary malignancies (n = 220). Organ allocation in Germany is regulated within the Eurotransplant system based on urgency as expressed by the Model for End-Stage Liver Disease score. In 2015, only 894 LTs (n = 48 from living donors) were performed at 23 German transplant centers, reflecting a shortage of organs...
August 2016: Liver Transplantation
Zhiqiang Tao, Yingying Lin, Maotong Hu, Shenghong Ding, Jianwei Li, Yongming Qiu
Chronic subdural hematoma (CSDH) is still a mysterious disease. Though great success has been has achieved by neuro-surgery treatment, the origin and development of CSDH remains unknown. Tremendous clinical observations have found the correlation of subdural effusion (SDE) and CSDH. However, systematic elucidation of CSDH's origin and progression is lacking while almost all the current hypothesis only explained partial phenomenon. This hypothesis proposes Interleukin (IL)-8 inducing neutrophil respiratory burst is the crucial impact when SDE evolves into CSDH...
January 2016: Medical Hypotheses
Saoussen Trabelsi, Nadia Mama, Maroua Chourabi, Maroua Haddaji Mastouri, Mohamed Ladib, Sergey Popov, Anna Burford, Moncef Mokni, Kalthoum Tlili, Hedi Krifa, Chris Jones, Mohamed Tahar Yacoubi, Ali Saad, Dorra H'mida-Ben Brahim
BACKGROUND: The meningeal hemangiopericytoma (MHPC) is a vascular tumor arising from pericytes. Most intracranial MHPCs resemble meningiomas (MNGs) in their clinical presentation and histological features and may therefore be misdiagnosed, despite important differences in prognosis. MATERIALS AND METHODS: We report 8 cases of MHPC and 5 cases of MNG collected from 2007 to 2011 from the Neuro-Surgery and Histopathology departments. All 13 samples were re reviewed by two independent pathologists and investigated by immunohistochemistry (IHC) using mesenchymal, epithelial and neuro-glial markers...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Amir Shahram Yousefi Kashi, Afshin Rakhsha, Mohammad Houshyari
BACKGROUND: Low-grade gliomas (LGGs) are the second most prevalent type of primary brain tumors in adults. The prognosis for LGGs can differ according to the clinical-pathological prognostic factors determined during diagnosis and treatment. The purpose of this study was to identify 10-year, disease-free survival (DFS), 10-year overall survival (OS), and related clinical-pathological prognostic factors of adult patients with supratentorial, low-grade gliomas who were treated with or without surgery and radiation therapy...
July 2015: Electronic Physician
A Özgür, E Dursun, Ö Ç Erdivanli, Z Ö Coşkun, S Terzi, G Emiroğlu, M Demirci
OBJECTIVES: The use of endoscopic techniques is becoming more widespread in otological and neuro-otological surgery. One such procedure, endoscopic tympanoplasty, is used in chronic otitis media treatment. This study aimed to analyse the results of endoscopic transcanal cartilage tympanoplasty. METHODS: Data of tubotympanic chronic otitis media patients who underwent transcanal endoscopic type I cartilage tympanoplasty between June 2012 and May 2013 were analysed...
November 2015: Journal of Laryngology and Otology
Vered Shkalim-Zemer, Shifra Ash, Helen Toledano, Yehuda Kollender, Josephine Issakov, Isaac Yaniv, Ian J Cohen
PURPOSE: Aggressive chemotherapy protocols for non-metastatic limb osteosarcoma have improved histological response without affecting prognosis. This study evaluated the toxicity and outcome of a dose-intensive, high-dose 3- to 5-drug pilot protocol, SCOS 89. METHODS: The cohort included 26 patients (14 male; ages 6.5-22 years) with non-metastatic limb osteosarcoma treated at a tertiary pediatric medical center between 1989 and 2013. Preoperatively, patients received two courses of once-weekly pulses of high-dose methotrexate (12-30 g/m(2)) for 2 weeks; doxorubicin (90 mg/m(2)) with dexrazoxane, combined with cisplatin (200 mg/m(2)), was added in week 3...
November 2015: Cancer Chemotherapy and Pharmacology
Alvaro Lassaletta, Eric Bouffet, Donald Mabbott, Abhaya V Kulkarni
Tumors of the posterior fossa (PF) account for up to 60 % of all childhood intracranial tumors. Over the last decades, the mortality rate of children with posterior fossa tumors has gradually decreased. While survival has been the primary objective in most reports, quality of survival increasingly appears to be an important indicator of a successful outcome. Children with a PF tumor can sustain damage to the cerebellum and other brain structures from the tumor itself, concomitant hydrocephalus, the consequences of treatment (surgery, chemotherapy, radiotherapy), or a combination of these factors...
October 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
S Mrabet, F Ellouze, S Ellini, M F Mrad
Biermer disease or pernicious anemia is an autoimmune atrophic gastritis characterized by the lack of secretion of gastric intrinsic factor. This leads to an insufficient absorption of vitamin B12 in the ileum. Clinical manifestations are mainly hematologic. Neuropsychiatric manifestations are known but are less frequent especially early in the disease. Inaugural neuropsychiatric arrays are rare and various thus making diagnosis difficult. In this article, we report through two clinical cases different neuropsychiatric manifestations revealing pernicious anemia...
December 2015: L'Encéphale
J C Espinós, R Turró, G Moragas, A Bronstone, J N Buchwald, F Mearin, A Mata, H Uchima, J Turró, S Delgado-Aros
BACKGROUND: Primary Obesity Surgery Endolumenal (POSE) is a novel bariatric endoscopic procedure that has been shown to reduce weight safely through 12 months. The study investigated potential mechanisms of weight loss following POSE. METHODS: Patients with class I-II obesity received transmural plications in the gastric fundus and distal gastric body. Patients were evaluated at baseline and at 2- and 6-month follow-up with gastric-emptying (GE) scintigraphy, a validated test of intake capacity (kcal) and plasma glucose homeostasis hormones/gastrointestinal peptides...
May 2016: Obesity Surgery
Esperanza Bas, Stefania Goncalves, Michelle Adams, Christine T Dinh, Jose M Bas, Thomas R Van De Water, Adrien A Eshraghi
Conservation of a patient's residual hearing and prevention of fibrous tissue/new bone formation around an electrode array are some of the major challenges in cochlear implant (CI) surgery. Although it is well-known that fibrotic tissue formation around the electrode array can interfere with hearing performance in implanted patients, and that associated intracochlear inflammation can initiate loss of residual hearing, little is known about the molecular and cellular mechanisms that promote this response in the cochlea...
2015: Frontiers in Cellular Neuroscience
Davide Bottari, Nikolaus F Troje, Pia Ley, Marlene Hense, Ramesh Kekunnaya, Brigitte Röder
Naturally occurring sensory deprivation in humans provides a unique opportunity to identify sensitive phases for the development of neuro-cognitive functions. Patients who had experienced a transient period of congenital visual deprivation due to bilateral dense cataracts (congenital cataract, cc) have shown, after visual re-afferentation, deficits in a number of higher visual functions including global motion and face processing. By contrast, biological motion (BM) perception seemed to be spared. The present study investigated the neural correlates of BM processing in a sample of 12 congenital cataract-reversal individuals who had underwent visual restoration surgery at the age of a few months up to several years...
October 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
O Gallego
Standard treatment for glioblastoma multiforme is surgery followed by radiotherapy and chemotherapy, generally with temozolomide. However, disease recurs in almost all patients. Diagnosis of progression is complex given the possibility of pseudoprogression. The Response Assessment in Neuro-Oncology criteria increase the sensitivity for detecting progression. Most patients will not be candidates for new surgery or re-irradiation, and anticancer drugs are the most common approach for second-line treatment, if the patient's condition allows...
August 2015: Current Oncology
Tej D Azad, Ram Kumar Shrestha, Silvia Vaca, Ali Niyaf, Amit Pradhananga, Gopal Sedain, Mohan R Sharma, Sushil K Shilpakar, Gerald A Grant
BACKGROUND: Central nervous system (CNS) tumors are the most common cause of cancer-related death in children. Little is known about the demographics and treatment of pediatric brain tumors in low- and middle-income countries (LMICs). METHODS: We performed a retrospective chart review of all pediatric patients who presented to the neurosurgical service at Tribhuvan University Teaching Hospital in Kathmandu, Nepal from 2009-2014 and collected information on patients <18 years old who received a diagnosis of a CNS tumor...
December 2015: World Neurosurgery
Nabeel Alshafai, Olesya Falenchuk, Michael D Cusimano
BACKGROUND: The publication of the International Subarachnoid Aneurysm Trial rapidly changed the management of patients with subarachnoid hemorrhage. The present and perceived future trends of aneurysm management have significant implications for patients and how we educate future cerebrovascular specialists. OBJECTIVE: To determine present perceived competencies of final-year neurosurgical residents who have just finished their residencies and to relate those to what practitioners from a variety of continents expect of these persons...
September 2015: Acta Neurochirurgica
Anthony Boyer, Jérémy Deverdun, Hugues Duffau, Emmanuelle Le Bars, François Molino, Nicolas Menjot de Champfleur, François Bonnetblanc
Hypometabolism has been observed in the contralesional cerebellar hemisphere after various supratentorial cortical lesions. It is unknown whether the consequences of the dee- and deafferentation subsequent to wide-awake surgery for brain diffuse low-grade glioma can be assessed within remote and unresected subcortical structures such as the cerebellum or thalamus. To answer this question, we have conducted several regional analyses. More specifically, we have performed amplitude of low-frequency fluctuations (neuronal activity magnitude) and regional homogeneity (local temporal correlations) analyses on resting state functional magnetic resonance imaging (rs-fMRI) data and at different time points, before and after surgery...
August 2016: Cerebellum
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