Eva Elina Buschmann, Eun-Ji Lee, Dorit Jacobi, Anne-Katrin Woischnig, Susann Ulusans, Martin Schumacher, Katherine H Smith, Nikolaos Pagonas, Peter Bramlage, Joachim Klisch, Philipp Hillmeister, Ivo R Buschmann
BACKGROUND AND AIMS: Arteriogenesis, the positive outward remodeling and growth of pre-existent collateral vessels, holds potential as a novel treatment for ischemic vascular disease. An extracranial arteriogenesis model in a pig will allow us to study molecular changes in a complex arteriolar network in a more clinically relevant large-animal model. To increase fluid shear stress in the brain, an experimental carotid arteriovenous fistula (AVF model) in minipigs was established, providing high flow through the extracranial rete mirabile...
March 3, 2018: Atherosclerosis