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https://www.readbyqxmd.com/read/29352526/ectrims-ean-guideline-on-the-pharmacological-treatment-of-people-with-multiple-sclerosis
#1
X Montalban, R Gold, A J Thompson, S Otero-Romero, M P Amato, D Chandraratna, M Clanet, G Comi, T Derfuss, F Fazekas, H P Hartung, E Havrdova, B Hemmer, L Kappos, R Liblau, C Lubetzki, E Marcus, D H Miller, T Olsson, S Pilling, K Selmaj, A Siva, P S Sorensen, M P Sormani, C Thalheim, H Wiendl, F Zipp
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a complex disease of the central nervous system. As new drugs are becoming available, knowledge on diagnosis and treatment must continuously evolve. There is therefore a need for a reference tool compiling current data on benefit and safety, to aid professionals in treatment decisions and use of resources across Europe. The European Committee of Treatment and Research in Multiple Sclerosis (ECTRIMS) and the European Academy of Neurology (EAN) have joined forces to meet this need...
January 19, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29341979/wilson-s-disease-in-children-a-position-paper-by-the-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-committee
#2
Piotr Socha, Wojciech Janczyk, Anil Dhawan, Ulrich Baumann, Lorenzo D'Antiga, Stuart Tanner, Raffaele Iorio, Pietro Vajro, Roderick Houwen, Björn Fischler, Antal Dezsofi, Nedim Hadzic, Loreto Hierro, Jörg Jahnel, Valérie McLin, Valerio Nobili, Francoise Smets, Henkjan J Verkade, Dominique Debray
BACKGROUND: Clinical presentations of Wilson's disease (WD) in childhood ranges from asymptomatic liver disease to cirrhosis or acute liver failure, while neurological and psychiatric symptoms are rare. The basic diagnostic approach includes serum ceruloplasmin and 24h-urinary copper excretion. Final diagnosis of WD can be established using a diagnostic scoring system based on symptoms, biochemical tests assessing copper metabolism and molecular analysis of mutations in the ATP7B gene...
October 26, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29341814/utilizing-a-rat-delayed-implantation-model-to-teach-integrative-endocrinology-and-reproductive-biology
#3
Rodney D Geisert, Michael F Smith, Amanda L Schmelzle, Jonathan A Green
In this teaching laboratory, the students are directed in an exercise that involves designing and performing an experiment to determine estrogen's role in regulating delayed implantation (diapause) in female rats. To encourage active participation by the students, a discussion question is provided before the laboratory exercise in which each student is asked to search the literature and provide written answers to questions and to formulate an experiment to test the role of ovarian estrogen in inducing implantation in female rats...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29339933/roles-for-librarians-in-systematic-reviews-a-scoping-review
#4
Angela J Spencer, Jonathan D Eldredge
Objective: What roles do librarians and information professionals play in conducting systematic reviews? Librarians are increasingly called upon to be involved in systematic reviews, but no study has considered all the roles librarians can perform. This inventory of existing and emerging roles aids in defining librarians' systematic reviews services. Methods: For this scoping review, the authors conducted controlled vocabulary and text-word searches in the PubMed; Library, Information Science & Technology Abstracts; and CINAHL databases...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29339931/assessment-of-knowledge-and-skills-in-information-literacy-instruction-for-rehabilitation-sciences-students-a-scoping-review
#5
Jill T Boruff, Pamela Harrison
Objective: This scoping review investigates how knowledge and skills are assessed in the information literacy (IL) instruction for students in physical therapy, occupational therapy, or speech-language pathology, regardless of whether the instruction was given by a librarian. The objectives were to discover what assessment measures were used, determine whether these assessment methods were tested for reliability and validity, and provide librarians with guidance on assessment methods to use in their instruction in evidence-based practice contexts...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29339510/artificial-intelligence-exploration-of-unstable-protocells-leads-to-predictable-properties-and-discovery-of-collective-behavior
#6
Laurie J Points, James Ward Taylor, Jonathan Grizou, Kevin Donkers, Leroy Cronin
Protocell models are used to investigate how cells might have first assembled on Earth. Some, like oil-in-water droplets, can be seemingly simple models, while able to exhibit complex and unpredictable behaviors. How such simple oil-in-water systems can come together to yield complex and life-like behaviors remains a key question. Herein, we illustrate how the combination of automated experimentation and image processing, physicochemical analysis, and machine learning allows significant advances to be made in understanding the driving forces behind oil-in-water droplet behaviors...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29333730/day-to-day-mastery-and-self-efficacy-changes-during-a-smoking-quit-attempt-two-studies
#7
Lisa M Warner, Gertraud Stadler, Janina Lüscher, Nina Knoll, Sibylle Ochsner, Rainer Hornung, Urte Scholz
OBJECTIVE: In social-cognitive theory, it is hypothesized that mastery experiences (successfully implementing behaviour change) are a source of self-efficacy, and self-efficacy increases the opportunity for experiencing mastery. Vicarious experiences (seeing others succeed) are suggested as another source of self-efficacy. However, the hypothesis of this reciprocal relationship has not been tested using a day-to-day design. DESIGN: This article reports findings from two intensive longitudinal studies, testing the reciprocal relationship of self-efficacy and its two main sources within the naturally occurring process of quitting smoking (without intervention)...
January 15, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#8
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330655/effectiveness-for-dentin-hypersensitivity-treatment-of-non-carious-cervical-lesions-a-meta-analysis
#9
REVIEW
Vittorio Moraschini, Larissa Salina da Costa, Gustavo Oliveira Dos Santos
OBJECTIVE: The aim of this review is to conduct a systematic review and meta-analysis comparing the effectiveness of in-home or in-office treatments for dentin hypersensitivity. MATERIALS AND METHODS: An electronic search without restriction on dates or languages was performed in four electronic databases until March 2017. In addition, hand-searches in regular journals and in the gray literature were also conducted. To develop the search strategy, clinical questions were formulated using the PICOS method...
January 12, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29329942/variational-neuroethology-answering-further-questions-reply-to-comments-on-answering-schr%C3%A3-dinger-s-question-a-free-energy-formulation
#10
Maxwell J D Ramstead, Paul B Badcock, Karl J Friston
No abstract text is available yet for this article.
January 8, 2018: Physics of Life Reviews
https://www.readbyqxmd.com/read/29329715/ten-questions-you-should-consider-before-submitting-an-article-to-a-scientific-journal
#11
A Falcó-Pegueroles, D Rodríguez-Martín
Investigating involves not only knowing the research methods and designs; it involves knowing the strategies for disseminating and publishing the results in scientific journals. An investigation is considered complete when it is published and is disclosed to the scientific community. The publication of a manuscript is not simple, since it involves examination by a rigorous editorial process evaluator to ensure the scientific quality of the proposal. The objective of this article is to communicate to potential authors the main errors or deficiencies that typically and routinely explain the decision by the referees of scientific journals not to accept a scientific article...
January 9, 2018: Enfermería Intensiva
https://www.readbyqxmd.com/read/29329196/is-the-skin-absorption-of-hydrocortisone-modified-by-the-variability-in-dosing-topical-products
#12
Daniel A Paterson, Jacqueline Hallier, Elizabeth Jenkins, Sarah F Cordery, M Begoña Delgado-Charro
Fingertip units have been proposed as a tool to standardize topical therapy with semisolid formulations. However, no studies to date have characterized the variability in dosing by patients using this concept and whether this variability ultimately affects the topical absorption of drugs. This work aimed to answer these two questions. A first study determined the dose measured, the area of spread and the area-normalized dose for a 1% hydrocortisone cream and ointment applied by members of the public using this dosing approach before and after brief counselling...
January 12, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29327921/the-nature-and-reactivity-of-ferryl-heme-in-compounds-i-and-ii
#13
Peter C E Moody, Emma L Raven
Aerobic organisms have evolved to activate oxygen from the atmosphere, which allows them to catalyze the oxidation of different kinds of substrates. This activation of oxygen is achieved by a metal center (usually iron or copper) buried within a metalloprotein. In the case of iron-containing heme enzymes, the activation of oxygen is achieved by formation of transient iron-oxo (ferryl) intermediates; these intermediates are called Compound I and Compound II. The Compound I and II intermediates were first discovered in the 1930s in horseradish peroxidase, and it is now known that these same species are used across the family of heme enzymes, which include all of the peroxidases, the heme catalases, the P450s, cytochrome c oxidase, and NO synthase...
January 12, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29327349/status-of-the-trait-concept-in-contemporary-personality-psychology-are-the-old-questions-still-the-burning-questions
#14
Małgorzata Fajkowska, Shulamith Kreitler
This special issue of Journal of Personality addresses one of the cardinal concerns of personality psychology, namely, the status of traits in contemporary personality science. Trait theory is a major scientific model for personality explanation and research. Although there have been critiques of traits, typically formulated from the point of view of the social-cognitive perspective, the trait approach can be viewed as a continuously developing paradigm. However, personality psychology persists in tackling burning questions concerning the status of traits that need to be answered...
February 2018: Journal of Personality
https://www.readbyqxmd.com/read/29325935/upgrading-gestalt-psychology-with-variational-neuroethology-the-case-of-perceptual-pleasures-comment-on-answering-schr%C3%A3-dinger-s-question-a-free-energy-formulation-by-m-j-desormeau-ramstead-et-al
#15
https://www.readbyqxmd.com/read/29325130/emergent-heterogeneous-micro-environments-in-biofilms-substratum-surface-heterogeneity-and-bacterial-adhesion-force-sensing
#16
Yijin Ren, Can Wang, Zhi Chen, Elaine Allan, Henny C van der Mei, Henk J Busscher
Phenotypically-heterogeneous micro-environments emerge as biofilms mature across different environments. Phenotypic-heterogeneity in biofilm sub-populations not obeying quorum sensing-dictated, collective group-behavior, may be considered as a strategy allowing non-conformists to survive hostile conditions. Heterogeneous phenotype development has been amply studied with respect to gene expression and genotypic changes, but 'biofilm genes' responsible for pre-programmed development of heterogeneous micro-environments in biofilms have never been discovered...
January 9, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29318772/mental-health-nursing-daring-to-be-different-special-and-leading-recovery-focused-care
#17
Peter Santangelo, Nicholas Procter, Denise Fassett
How mental health nursing is differentiated from other disciplines and professions, and what special contribution mental health nurses make to health services, is a question at the heart of contemporary practice. One of the significant challenges for mental health nurses is identifying, developing and advancing those aspects of their practice that they consider differentiate them in the multi-disciplinary mental health care team and to articulate clearly what a mental health nurse is and does. This paper draws on data from interviews with 36 mental health nurses in Australia who identified their practice as autonomous...
February 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29315542/making-unformulated-experience-real-through-painting-painting-and-psychoanalytic-psychotherapy-practice-as-two-ways-of-making-sense
#18
Karen M Schwartz
I contend that painting, like psychoanalytic psychotherapy, is an intersubjective process able to connect hearts and minds of painters and viewers alike, because the creative process of making a painting brings painters into more complex and more animated relationship with themselves. My own painting process is largely nonverbal. Interactions between me and my evolving artwork-in-process reveal experiences, thoughts, and feelings not yet formulated in words, and so, not available explicitly to conscious awareness until visual representation allows questions of meaning and intention to be thought about and elaborated in the usual, verbal sense...
January 5, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29315487/using-extensional-flow-to-reveal-diverse-aggregation-landscapes-for-three-igg1-molecules
#19
Leon F Willis, Amit Kumar, John Dobson, Nick Bond, David Lowe, Richard Turner, Sheena E Radford, Nikil Kapur, David J Brockwell
Monoclonal antibodies (mAbs) currently dominate the biopharmaceutical sector due to their potency and efficacy against a range of disease targets. These proteinaceous therapeutics are, however, susceptible to unfolding, mis-folding and aggregation by environmental perturbations. Aggregation thus poses an enormous challenge to biopharmaceutical development, production, formulation and storage. Hydrodynamic forces have also been linked to aggregation, but the ability of different flow fields (e.g. shear and extensional flow) to trigger aggregation has remained unclear...
January 8, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29314775/the-relationship-between-digit-independence-and-digital-sesamoids-in-humans-and-a-proposal-of-a-new-digital-sesamoid-evolutionary-hypothesis
#20
Kaissar Yammine
Digital sesamoids are found in the metapodial-phalangeal joints of most mammals and quadrupedal tetrapods, yet their functional significance is still unclear. During primate evolution, a slight decline in their frequency has been associated with brachiation in gibbons, followed by a quasi-complete absence in orangutans then a slight resurgence occurred in gorillas and chimpanzees. Simultaneously, forearm muscles showed a progressive division in hominoid evolution towards a more "individualistic" musculature yielding more mobility and independence to some fingers...
January 3, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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