keyword
https://read.qxmd.com/read/38496637/celsr3-drives-development-and-connectivity-of-the-acoustic-startle-hindbrain-circuit
#21
Joy H Meserve, Maria F Navarro, Elelbin A Ortiz, Michael Granato
UNLABELLED: In the developing brain, groups of neurons organize into functional circuits that direct diverse behaviors. One such behavior is the evolutionarily conserved acoustic startle response, which in zebrafish is mediated by a well-defined hindbrain circuit. While numerous molecular pathways that guide neurons to their synaptic partners have been identified, it is unclear if and to what extent distinct neuron populations in the startle circuit utilize shared molecular pathways to ensure coordinated development...
March 7, 2024: bioRxiv
https://read.qxmd.com/read/38496416/neurodevelopmental-disorders-associated-variants-in-adat3-disrupt-the-activity-of-the-adat2-adat3-trna-deaminase-complex-and-impair-neuronal-migration
#22
Jordi Del-Pozo-Rodriguez, Peggy Tilly, Romain Lecat, Hugo Rolando Vaca, Laureline Mosser, Till Balla, Marina Vitoria Gomes, Elizabeth Ramos-Morales, Elena Brivio, Thalia Salinas-Giégé, Grace VanNoy, Eleina M England, Alysia Kern Lovgren, Melanie O'Leary, Maya Chopra, Dustin Gable, Aisha Alnuzha, Mona Kamel, Nihal Almenabawy, Anne O'Donnell-Luria, Jennifer E Neil, Joseph G Gleeson, Christopher A Walsh, Nour Elkhateeb, Laila Selim, Siddharth Srivastava, Danny D Nedialkova, Laurence Drouard, Christophe Romier, Efil Bayam, Juliette D Godin
The ADAT2/ADAT3 complex catalyzes the adenosine to inosine modification at the wobble position of eukaryotic tRNAs. Mutations in ADAT3 , the catalytically inactive subunit of the ADAT2/ADAT3 complex, have been identified in patients presenting with severe neurodevelopmental disorders (NDDs). Yet, the physiological function of ADAT2/ADAT3 complex during brain development remains totally unknown. Here we showed that maintaining a proper level of ADAT2/ADAT3 catalytic activity is required for correct radial migration of projection neurons in the developing mouse cortex...
March 5, 2024: medRxiv
https://read.qxmd.com/read/38492673/interactions-between-skin-resident-dendritic-and-langerhans-cells-and-pain-sensing-neurons
#23
REVIEW
Natalie C Wilcox, Golnar Taheri, Katherine Halievski, Sebastien Talbot, Jaqueline R Silva, Nader Ghasemlou
Various immune cells in the skin contribute to its function as a first line of defence against infection/disease, while its dense innervation by pain-sensing sensory neurons protects the host from injury/damage signals. Dendritic cells (DCs) are a heterogeneous population of cells that link the innate immune response to the adaptive response by capturing, processing, and presenting antigens to promote T-cell differentiation and activation. DCs are abundant across peripheral tissues, including the skin, where they are found in the dermis and epidermis...
March 14, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38491210/dysregulated-n-6-methyladenosine-modification-in-peripheral-immune-cells-contributes-to-the-pathogenesis-of-amyotrophic-lateral-sclerosis
#24
JOURNAL ARTICLE
Di He, Xunzhe Yang, Liyang Liu, Dongchao Shen, Qing Liu, Mingsheng Liu, Xue Zhang, Liying Cui
Amyotrophic lateral sclerosis (ALS) is a progressive neurogenerative disorder with uncertain origins. Emerging evidence implicates N6-methyladenosine (m6 A) modification in ALS pathogenesis. Methylated RNA immunoprecipitation sequencing (MeRIP-seq) and liquid chromatography-mass spectrometry were utilized for m6 A profiling in peripheral immune cells and serum proteome analysis, respectively, in patients with ALS (n = 16) and controls (n = 6). The single-cell transcriptomic dataset (GSE174332) of primary motor cortex was further analyzed to illuminate the biological implications of differentially methylated genes and cell communication changes...
March 16, 2024: Frontiers of Medicine
https://read.qxmd.com/read/38490949/deficits-in-olfactory-system-neurogenesis-in-neurodevelopmental-disorders
#25
REVIEW
Sean C Sweat, Claire E J Cheetham
The role of neurogenesis in neurodevelopmental disorders (NDDs) merits much attention. The complex process by which stem cells produce daughter cells that in turn differentiate into neurons, migrate various distances, and form synaptic connections that are then refined by neuronal activity or experience is integral to the development of the nervous system. Given the continued postnatal neurogenesis that occurs in the mammalian olfactory system, it provides an ideal model for understanding how disruptions in distinct stages of neurogenesis contribute to the pathophysiology of various NDDs...
April 2024: Genesis: the Journal of Genetics and Development
https://read.qxmd.com/read/38488687/illuminating-the-terminal-nerve-uncovering-the-link-between-gnrh-1-neuron-and-olfactory-development
#26
JOURNAL ARTICLE
Enrico Amato, Ed Zandro M Taroc, Paolo E Forni
During embryonic development, the olfactory placode (OP) generates migratory neurons, including olfactory pioneer neurons, cells of the terminal nerve (TN), gonadotropin-releasing hormone-1 (GnRH-1) neurons, and other uncharacterized neurons. Pioneer neurons from the OP induce olfactory bulb (OB) morphogenesis. In mice, GnRH-1 neurons appear in the olfactory system around mid-gestation and migrate via the TN axons to different brain regions. The GnRH-1 neurons are crucial in controlling the hypothalamic-pituitary-gonadal axis...
March 2024: Journal of Comparative Neurology
https://read.qxmd.com/read/38488530/involvement-of-microglia-expressed-ms4a6a-in-the-onset-of-glioblastoma
#27
JOURNAL ARTICLE
Wenhao Lv, Shengyan Lin, Zhenxing Zuo, Zhihui Huang, Yongjie Wang
Glioblastoma multiforme (GBM) represents the deadliest form of brain tumour, characterized by its low survival rate and grim prognosis. Cytokines released from glioma-associated microglia/macrophages are involved in establishing the tumour microenvironment, thereby crucially promoting GBM progression. MS4A6A polymorphism was confirmed to be associated with neurodegenerative and polymorphism disease pathobiology, but whether it participates in the regulation of GBM and the underlying mechanisms is still not elucidated...
March 15, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38485468/altered-hippocampal-doublecortin-expression-in-parkinson-s-disease
#28
JOURNAL ARTICLE
Evelini Plácido, David J Koss, Tiago Fleming Outeiro, Patricia S Brocardo
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by motor and non-motor symptoms. Motor symptoms include bradykinesia, resting tremors, muscular rigidity, and postural instability, while non-motor symptoms include cognitive impairments, mood disturbances, sleep disturbances, autonomic dysfunction, and sensory abnormalities. Some of these symptoms may be influenced by the proper hippocampus functioning, including adult neurogenesis. Doublecortin (DCX) is a microtubule-associated protein that plays a pivotal role in the development and differentiation of migrating neurons...
March 14, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38477830/n-cadherin-dynamically-regulates-pediatric-glioma-cell-migration-in-complex-environments
#29
JOURNAL ARTICLE
Dayoung Kim, James M Olson, Jonathan A Cooper
Pediatric high-grade gliomas are highly invasive and essentially incurable. Glioma cells migrate between neurons and glia, along axon tracts, and through extracellular matrix surrounding blood vessels and underlying the pia. Mechanisms that allow adaptation to such complex environments are poorly understood. N-cadherin is highly expressed in pediatric gliomas and associated with shorter survival. We found that intercellular homotypic N-cadherin interactions differentially regulate glioma migration according to the microenvironment, stimulating migration on cultured neurons or astrocytes but inhibiting invasion into reconstituted or astrocyte-deposited extracellular matrix...
June 3, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38474091/uba6-inhibition-accelerates-lysosomal-trpml1-depletion-and-exosomal-secretion-in-lung-cancer-cells
#30
JOURNAL ARTICLE
Dongun Lee, Peter Chang-Whan Lee, Jeong Hee Hong
Ubiquitin-like modifier-activating enzyme 6 (UBA6) is a member of the E1 enzyme family, which initiates the ubiquitin-proteasome system (UPS). The UPS plays critical roles not only in protein degradation but also in various cellular functions, including neuronal signaling, myocardial remodeling, immune cell differentiation, and cancer development. However, the specific role of UBA6 in cellular functions is not fully elucidated in comparison with the roles of the UPS. It has been known that the E1 enzyme is associated with the motility of cancer cells...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38470760/polystyrene-nano-and-microplastic-particles-induce-an-inflammatory-gene-expression-profile-in-rat-neural-stem-cell-derived-astrocytes-in-vitro
#31
JOURNAL ARTICLE
Kristen A Marcellus, Steven Bugiel, Andrée Nunnikhoven, Ivan Curran, Santokh S Gill
Microplastics are considered an emerging environmental pollutant due to their ubiquitous presence in the environment. However, the potential impact of microplastics on human health warrants further research. Recent studies have reported neurobehavioral and neurotoxic effects in marine and rodent models; however, their impact on the underlying cellular physiology in mammals remains unclear. Herein, we exposed neural stem cells and neural stem cell-derived astrocytes, oligodendrocytes, and neurons to various sizes and concentrations of polystyrene nano- and microplastics...
February 27, 2024: Nanomaterials
https://read.qxmd.com/read/38469915/the-neuroprotective-effect-of-exogen-melatonin-upon-fetal-hippocampus-damage-caused-by-high-dose-caffeine-administration-in-pregnant-rats
#32
JOURNAL ARTICLE
Yağmur Köse, Cansın Şirin, Ali Çağlar Turgut, Canberk Tomruk, Yiğit Uyanıkgil, Mehmet Turgut
OBJECTIVE: The aim of this study is to evaluate whether exogenous melatonin (MEL) mitigates the deleterious effects of high-dose caffeine (CAF) administration in pregnant rats upon the fetal hippocampus. MATERIALS AND METHODS: A total of 32 adult Wistar albino female rats were divided into four groups after conception (n = 8). At 9-20 days of pregnancy, intraperitoneal (i.p.) MEL was administered at a dose of 10 mg/kg/day in the MEL group, while i...
March 12, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38467271/boundary-cap-neural-crest-stem-cells-promote-angiogenesis-after-transplantation-to-avulsed-dorsal-roots-in-mice-and-induce-migration-of-endothelial-cells-in-3d-printed-scaffolds
#33
JOURNAL ARTICLE
Carl Trolle, Yilin Han, Shivaprakash Jagalur Mutt, Gustaf Christoffersson, Elena N Kozlova
Dorsal root avulsion injuries lead to loss of sensation and to reorganization of blood vessels (BVs) in the injured area. The inability of injured sensory axons to re-enter the spinal cord results in permanent loss of sensation, and often also leads to the development of neuropathic pain. Approaches that restore connection between peripheral sensory axons and their CNS targets are thus urgently need. Previous research has shown that sensory axons from peripherally grafted human sensory neurons are able to enter the spinal cord by growing along BVs which penetrate the CNS from the spinal cord surface...
March 9, 2024: Neuroscience Letters
https://read.qxmd.com/read/38466184/manipulation-of-the-nuclear-envelope-associated-protein-slap-during-mammalian-brain-development-affects-cortical-lamination-and-exploratory-behavior
#34
JOURNAL ARTICLE
Ivan Mestres, Azra Atabay, Joan-Carles Escolano, Solveig Arndt, Klara Schmidtke, Maximilian Einsiedel, Melina Patsonis, Lizbeth Airais Bolaños-Castro, Maximina Yun, Nadine Bernhardt, Anna Taubenberger, Federico Calegari
Here, we report the first characterization of the effects resulting from the manipulation of Soluble-Lamin Associated Protein (SLAP) expression during mammalian brain development. We found that SLAP localizes to the nuclear envelope and when overexpressed causes changes in nuclear morphology and lengthening of mitosis. SLAP overexpression in apical progenitors of the developing mouse brain altered asymmetric cell division, neurogenic commitment and neuronal migration ultimately resulting in unbalance in the proportion of upper, relative to deeper, neuronal layers...
March 1, 2024: Biology Open
https://read.qxmd.com/read/38465576/a-recurrent-missense-variant-in-the-e3-ubiquitin-ligase-substrate-recognition-subunit-fem1b-causes-a-rare-syndromic-neurodevelopmental-disorder
#35
JOURNAL ARTICLE
François Lecoquierre, A Mattijs Punt, Frédéric Ebstein, Ilse Wallaard, Rob Verhagen, Maja Studencka-Turski, Yannis Duffourd, Sébastien Moutton, Frédédic Tran Mau-Them, Christophe Philippe, John Dean, Stephen Tennant, Alice S Brooks, Marjon A van Slegtenhorst, Julie A Jurgens, Brenda J Barry, Wai-Man Chan, Eleina M England, Mayra Martinez Ojeda, Elizabeth C Engle, Caroline D Robson, Michelle Morrow, A Micheil Innes, Ryan Lamont, Matthea Sanderson, Elke Krüger, Christel Thauvin, Ben Distel, Laurence Faivre, Ype Elgersma, Antonio Vitobello
PURPOSE: FEM1B acts as a substrate recognition subunit for ubiquitin ligase complexes belonging to the CRL2 E3 family. Several biological functions have been proposed for FEM1B, including a structurally resolved function as a sensor for redox cell status by controlling mitochondrial activity, but its implication in human disease remains elusive. METHODS: To understand the involvement of FEM1B in human disease, we made use of Matchmaker exchange platforms to identify individuals with de novo variants in FEM1B and performed their clinical evaluation...
March 7, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://read.qxmd.com/read/38464338/influence-of-zika-virus-on-the-cytotoxicity-cell-adhesion-apoptosis-and-inflammatory-markers-of-glioblastoma-cells
#36
JOURNAL ARTICLE
Daniel Rodrigo Marinowic, Gabriele Goulart Zanirati, Pamella Nunes Azevedo, Ângela Zanatta, Ismael Plentz, Allan Marinho Alcará, Fernanda Bueno Morrone, Thamiris Becker Scheffel, Angélica Regina Cappellari, Paulo Michel Roehe, Ana Paula Muterle Varela, Denise Cantarelli Machado, Fabiana Spillari Viola, Jaderson Costa Da Costa
Glioblastoma (GBM) is one of the most common types of brain tumor in adults. Despite the availability of treatments for this disease, GBM remains one of the most lethal and difficult types of tumors to treat, and thus, a majority of patients die within 2 years of diagnosis. Infection with Zika virus (ZIKV) inhibits cell proliferation and induces apoptosis, particularly in developing neuronal cells, and thus could potentially be considered an alternative for GBM treatment. In the present study, two GBM cell lines (U-138 and U-251) were infected with ZIKV at different multiplicities of infection (0...
April 2024: Oncology Letters
https://read.qxmd.com/read/38462447/serotonin-receptors-as-a-potential-target-in-the-treatment-of-alzheimer-s-disease
#37
REVIEW
Dmitrii V Eremin, Elena M Kondaurova, Aleksander Ya Rodnyy, Camilla A Molobekova, Dmitrii A Kudlay, Vladimir S Naumenko
Alzheimer's disease (AD) is the most common cause of dementia worldwide that has an increasing impact on aging societies. Besides its critical role in the control of various physiological functions and behavior, brain serotonin (5-HT) system is involved in the regulation of migration, proliferation, differentiation, maturation, and programmed death of neurons. At the same time, a growing body of evidence indicates the involvement of 5-HT neurotransmission in the formation of insoluble aggregates of β-amyloid and tau protein, the main histopathological signs of AD...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38461182/identification-of-the-growth-cone-as-a-probe-and-driver-of-neuronal-migration-in-the-injured-brain
#38
JOURNAL ARTICLE
Chikako Nakajima, Masato Sawada, Erika Umeda, Yuma Takagi, Norihiko Nakashima, Kazuya Kuboyama, Naoko Kaneko, Satoaki Yamamoto, Haruno Nakamura, Naoki Shimada, Koichiro Nakamura, Kumiko Matsuno, Shoji Uesugi, Nynke A Vepřek, Florian Küllmer, Veselin Nasufović, Hironobu Uchiyama, Masaru Nakada, Yuji Otsuka, Yasuyuki Ito, Vicente Herranz-Pérez, José Manuel García-Verdugo, Nobuhiko Ohno, Hans-Dieter Arndt, Dirk Trauner, Yasuhiko Tabata, Michihiro Igarashi, Kazunobu Sawamoto
Axonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and functional responsivity through protein tyrosine phosphatase receptor type sigma (PTPσ). Migrating-neuron growth cones respond to chondroitin sulfate (CS) through PTPσ and collapse, which leads to inhibition of neuronal migration. In the presence of CS, the growth cones can revert to their extended morphology when their leading filopodia interact with heparan sulfate (HS), thus re-enabling neuronal migration...
March 9, 2024: Nature Communications
https://read.qxmd.com/read/38458575/netrin-1-as-a-neural-guidance-protein-in-development-and-reinnervation-of-the-larynx
#39
JOURNAL ARTICLE
Ignacio Hernandez-Morato, Shira Koss, Emily Honzel, Michael J Pitman
Neural guidance proteins participate in motor neuron migration, axonal projection, and muscle fiber innervation during development. One of the guidance proteins that participates in axonal pathfinding is Netrin-1. Despite the well-known role of Netrin-1 in embryogenesis of central nervous tissue, it is still unclear how the expression of this guidance protein contributes to primary innervation of the periphery, as well as reinnervation. This is especially true in the larynx where Netrin-1 is upregulated within the intrinsic laryngeal muscles after nerve injury and where blocking of Netrin-1 alters the pattern of reinnervation of the intrinsic laryngeal muscles...
March 6, 2024: Annals of Anatomy
https://read.qxmd.com/read/38455426/neuron-derived-neurotensin-promotes-pancreatic-cancer-invasiveness-and-gemcitabine-resistance-via-the-ntsr1-akt-pathway
#40
JOURNAL ARTICLE
Yu-Hsuan Hung, Hui-Ching Wang, Shih-Han Hsu, Li-Yun Wang, Ya-Li Tsai, Yung-Yeh Su, Wen-Chun Hung, Li-Tzong Chen
Perineural invasion and neurogenesis are frequently observed in pancreatic ductal adenocarcinoma (PDAC) and link to poor outcome. However, how neural factors affect PDAC prognosis and the underlying mechanism as well as counteracting therapeutic are still unclear. In silico systematic analysis was performed with PROGgene to identify potential neural factor and its receptor in pancreatic cancer. In vitro assays including migration, invasion, 3D recruitment, and gemcitabine resistance were performed to study the effect of neuron-derived neurotensin (NTS) on pancreatic cancer behavior...
2024: American Journal of Cancer Research
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