keyword
MENU ▼
Read by QxMD icon Read
search

targeted muscle reinnervation

keyword
https://www.readbyqxmd.com/read/27879592/reinnervated-split-muscle-technique-for-creating-additional-myoelectric-sites-in-an-animal-model
#1
Maria Florencia Deslivia, Hyun-Joo Lee, Rizki Fajar Zulkarnain, Bin Zhu, Arnold Adikrishna, In-Ho Jeon, Keehoon Kim
BACKGROUND: This study proposes a novel reinnervated split-muscle operation to create additional myoelectric sites as sources of command signals of myoelectric prostheses for enhanced dexterous hand-to-wrist motions. The aim of this study was to investigate the postprocedure electromyographic properties of the muscles as distinct myoelectric sites in a rat model. METHODS: The reinnervated split-muscle group (n = 6) had the gastrocnemius muscle separated along its longitudinal axis and nerves transferred to each new muscle (peroneal nerve to lateral muscle head and tibial to medial one); the non-split-muscle group (n = 6) only had nerve transfers with its muscle intact...
December 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27824734/targeted-muscle-reinnervation-for-transradial-amputation-description-of-operative-technique
#2
Emily N Morgan, Benjamin Kyle Potter, Jason M Souza, Scott M Tintle, George P Nanos
Targeted muscle reinnervation (TMR) is a revolutionary surgical technique that, together with advances in upper extremity prostheses and advanced neuromuscular pattern recognition, allows intuitive and coordinated control in multiple planes of motion for shoulder disarticulation and transhumeral amputees. TMR also may provide improvement in neuroma-related pain and may represent an opportunity for sensory reinnervation as advances in prostheses and haptic feedback progress. Although most commonly utilized following shoulder disarticulation and transhumeral amputations, TMR techniques also represent an exciting opportunity for improvement in integrated prosthesis control and neuroma-related pain improvement in patients with transradial amputations...
December 2016: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/27737470/outcomes-of-muscle-reinnervation-with-direct-nerve-implantation-into-the-native-motor-zone-of-the-target-muscle
#3
Stanislaw Sobotka, Jingming Chen, Themba Nyirenda, Liancai Mu
Background Our recent work has demonstrated that the native motor zone (NMZ) within a given skeletal muscle is the best site for muscle reinnervation. This study was designed to explore the outcomes of direct nerve implantation (DNI) into the NMZ of denervated sternomastoid (SM) muscle in a rat model. Methods The right SM muscle was experimentally denervated by transecting its innervating nerve. The proximal stump of the severed SM nerve was immediately implanted into a small muscle slit made in the NMZ of the muscle where denervated motor endplates were concentrated...
October 13, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27661421/what-is-new-in-trauma-related-amputations
#4
Scott M Tintle, Christopher LeBrun, James R Ficke, Benjamin K Potter
Traumatic and trauma-related amputations represent unfortunate sequelae of severe injury, but should not be viewed as a treatment failure and may represent the best reconstructive option for some patients. Lessons from recent military conflicts have guided the evolution of modern surgical techniques and rehabilitation management of this challenging patient population, and treatment at a specialty center may improve patient outcomes. Despite appropriate management, however, surgical complications remain common and revision surgery is often necessary...
October 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27585036/the-fibular-nerve-injury-method-a-reliable-assay-to-identify-and-test-factors-that-repair-neuromuscular-junctions
#5
William Dalkin, Thomas Taetzsch, Gregorio Valdez
The neuromuscular junction (NMJ) undergoes deleterious structural and functional changes as a result of aging, injury and disease. Thus, it is imperative to understand the cellular and molecular changes involved in maintaining and repairing NMJs. For this purpose, we have developed a method to reliably and consistently examine regenerating NMJs in mice. This nerve injury method involves crushing the common fibular nerve as it passes over the lateral head of the gastrocnemius muscle tendon near the knee. Using 70 day old female mice, we demonstrate that motor axons begin to reinnervate previous postsynaptic targets within 7 days post-crush...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27508011/collateral-development-and-spinal-motor-reorganization-after-nerve-injury-and-repair
#6
Youlai Yu, Peixun Zhang, Na Han, Yuhui Kou, Xiaofeng Yin, Baoguo Jiang
Functional recovery is often unsatisfactory after severe extended nerve defects or proximal nerve trunks injuries repaired by traditional repair methods, as the long regeneration distance for the regenerated axons to reinnervate their original target end-organs. The proximal nerve stump can regenerate with many collaterals that reinnervate the distal stump after peripheral nerve injury, it may be possible to use nearby fewer nerve fibers to repair more nerve fibers at the distal end to shorten the regenerating distance...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27475929/muscle-specific-nucleus-ambiguus-neurons-isolation-and-culturing
#7
Ignacio Hernández-Morato, Michael J Pitman, Sansar Sharma
BACKGROUND: Peripheral nerve injury leads to a regenerative state. However, the reinnervation process is highly non-selective. Growing axons are often misrouted and establish aberrant synapsis to abductor or adductor muscles. Determining the complex properties of abductor and adductor motoneurons in a neuron culture, may lay the groundwork for future studies on axon guidance, leading to a clinical treatment for a selective reinnervation. NEW METHOD: In the present study we develop a neuron culture protocol to isolate recurrent laryngeal nerve abductor and adductor motoneurons in order to study their unique properties...
July 27, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27466130/upslope-treadmill-exercise-enhances-motor-axon-regeneration-but-not-functional-recovery-following-peripheral-nerve-injury
#8
Jill Cannoy, Sam Crowley, Allen Jarratt, Kelly LeFevere Werts, Krista Osborne, Sohee Park, Arthur W English
Following peripheral nerve injury, moderate daily exercise conducted on a level treadmill results in enhanced axon regeneration and modest improvements in functional recovery. If the exercise is conducted on an upwardly inclined treadmill, even more motor axons regenerate successfully and reinnervate muscle targets. Whether this increased motor axon regeneration also results in greater improvement in functional recovery from sciatic nerve injury was studied. Axon regeneration and muscle reinnervation were studied in Lewis rats over an 11 wk postinjury period using stimulus evoked electromyographic (EMG) responses in the soleus muscle of awake animals...
September 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27192539/therapeutic-augmentation-of-the-growth-hormone-axis-to-improve-outcomes-following-peripheral-nerve-injury
#9
Sami H Tuffaha, Prateush Singh, Joshua D Budihardjo, Kenneth R Means, James P Higgins, Jaimie T Shores, Roberto Salvatori, Ahmet Höke, W P Andrew Lee, Gerald Brandacher
INTRODUCTION: Peripheral nerve injuries often result in debilitating motor and sensory deficits. There are currently no therapeutic agents that are clinically available to enhance the regenerative process. Following surgical repair, axons often must regenerate long distances to reach and reinnervate distal targets. Progressive atrophy of denervated muscle and Schwann cells (SCs) prior to reinnervation contributes to poor outcomes. Growth hormone (GH)-based therapies have the potential to accelerate axonal regeneration while at the same time limiting atrophy of muscle and the distal regenerative pathway prior to reinnervation...
October 2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/27094121/comparative-outcome-measures-in-peripheral-regeneration-studies
#10
Stephen W P Kemp, Paul S Cederna, Rajiv Midha
Traumatic peripheral nerve injuries are common and often result in partial or permanent paralysis, numbness of the affected limb, and debilitating neuropathic pain. Experimental animal models of nerve injury have utilized a diversity of outcome measures to examine functional recovery following injury. Four primary categories of outcome measures of regenerative success including retrograde labeling with counts of regenerating neurons, immunohistochemistry and histomorphometry, reinnervation of target muscles, and behavioral analysis of recovery will be reviewed...
April 16, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/26994857/polyethylene-glycol-fusion-repair-prevents-reinnervation-accuracy-in-rat-peripheral-nerve
#11
Grant A Robinson, Roger D Madison
Functional recovery following a peripheral nerve injury is made easier when regenerating axons correctly reinnervate their original targets. Polyethylene glycol (PEG) has recently been used in attempts to fuse severed peripheral axons during suture-based repair, but an analysis of target selectivity following such repair has not been undertaken. The rat femoral nerve (in which muscle and cutaneous pathways comingle proximally but segregate distally into separate terminal nerve branches) is a convenient in vivo model for assessing motor neuron regeneration accuracy...
July 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/26932982/cutaneous-sensory-outcomes-from-three-transhumeral-targeted-reinnervation-cases
#12
Jacqueline S Hebert, K Ming Chan, Michael R Dawson
BACKGROUND: Although targeted muscle reinnervation has been shown to be effective in enhancing prosthetic control for upper limb amputees, restored hand sensations have been variable. An understanding of possible sensory feedback channels is crucial in working toward more effective closed-loop prosthetic control. OBJECTIVES: To compare sensory outcomes of different targeted sensory reinnervation approaches. STUDY DESIGN: Case series, cross-sectional, and retrospective...
June 2016: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/26901631/motor-unit-characteristics-after-targeted-muscle-reinnervation
#13
Tamás Kapelner, Ning Jiang, Aleš Holobar, Ivan Vujaklija, Aidan D Roche, Dario Farina, Oskar C Aszmann
Targeted muscle reinnervation (TMR) is a surgical procedure used to redirect nerves originally controlling muscles of the amputated limb into remaining muscles above the amputation, to treat phantom limb pain and facilitate prosthetic control. While this procedure effectively establishes robust prosthetic control, there is little knowledge on the behavior and characteristics of the reinnervated motor units. In this study we compared the m. pectoralis of five TMR patients to nine able-bodied controls with respect to motor unit action potential (MUAP) characteristics...
2016: PloS One
https://www.readbyqxmd.com/read/26692833/delayed-peripheral-nerve-repair-methods-including-surgical-cross-bridging-to-promote-nerve-regeneration
#14
REVIEW
Tessa Gordon, Placheta Eva, Gregory H Borschel
Despite the capacity of Schwann cells to support peripheral nerve regeneration, functional recovery after nerve injuries is frequently poor, especially for proximal injuries that require regenerating axons to grow over long distances to reinnervate distal targets. Nerve transfers, where small fascicles from an adjacent intact nerve are coapted to the nerve stump of a nearby denervated muscle, allow for functional return but at the expense of reduced numbers of innervating nerves. A 1-hour period of 20 Hz electrical nerve stimulation via electrodes proximal to an injury site accelerates axon outgrowth to hasten target reinnervation in rats and humans, even after delayed surgery...
October 2015: Neural Regeneration Research
https://www.readbyqxmd.com/read/26643959/long-term-decoding-of-movement-force-and-direction-with-a-wireless-myoelectric-implant
#15
Pierre Morel, Enrico Ferrea, Bahareh Taghizadeh-Sarshouri, Josep Marcel Cardona Audí, Roman Ruff, Klaus-Peter Hoffmann, Sören Lewis, Michael Russold, Hans Dietl, Lait Abu-Saleh, Dietmar Schroeder, Wolfgang Krautschneider, Thomas Meiners, Alexander Gail
OBJECTIVE: The ease of use and number of degrees of freedom of current myoelectric hand prostheses is limited by the information content and reliability of the surface electromyography (sEMG) signals used to control them. For example, cross-talk limits the capacity to pick up signals from small or deep muscles, such as the forearm muscles for distal arm amputations, or sites of targeted muscle reinnervation (TMR) for proximal amputations. Here we test if signals recorded from the fully implanted, induction-powered wireless Myoplant system allow long-term decoding of continuous as well as discrete movement parameters with better reliability than equivalent sEMG recordings...
February 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/26613205/role-of-c-jun-n-terminal-kinase-in-late-nerve-regeneration%C3%A2-monitored-by-in%C3%A2-vivo-imaging-of-thy1-yellow-fluorescent-protein-transgenic-mice
#16
Nguyen H Tu, Tayo Katano, Shinji Matsumura, Vuong Minh Pham, Tadatoshi Muratani, Toshiaki Minami, Seiji Ito
The restoration of function to injured peripheral nerves separated by a gap requires regeneration across it and reinnervation to target organs. To elucidate these processes, we have established an in vivo monitoring system of nerve regeneration in thy1-yellow fluorescent protein transgenic mice expressing a fluorescent protein in their nervous system. Here we demonstrated that motor and sensory nerves were regenerated in a coordinated fashion across the gap and that the functional recovery of the response to mechanical stimuli correlated well with sensory innervation to the foot...
February 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/26530091/microarray-analysis-gene-expression-profiles-in-laryngeal-muscle-after-recurrent-laryngeal-nerve-injury
#17
Khadijeh Bijangi-Vishehsaraei, Kevin Blum, Hongji Zhang, Ahmad R Safa, Stacey L Halum
OBJECTIVES: The pathophysiology of recurrent laryngeal nerve (RLN) transection injury is rare in that it is characteristically followed by a high degree of spontaneous reinnervation, with reinnervation of the laryngeal adductor complex (AC) preceding that of the abducting posterior cricoarytenoid (PCA) muscle. Here, we aim to elucidate the differentially expressed myogenic factors following RLN injury that may be at least partially responsible for the spontaneous reinnervation. METHODS: F344 male rats underwent RLN injury (n = 12) or sham surgery (n = 12)...
March 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/26527583/functional-and-clinical-outcomes-of-upper-extremity-amputation
#18
REVIEW
Peter Fitzgibbons, Gleb Medvedev
Upper extremity amputation is an uncommon but often necessary procedure. It can be required as a result of trauma, infection, or malignancy. Amputation is a life-changing procedure. Careful planning for it must not only include the level of amputation and assurance of durable soft-tissue coverage of the amputation site, but it must also consider patients' goals and occupations, as well as social factors affecting amputees. The choice of prosthesis is an individual matter, but new technology permits lighter and more multifunctional prostheses...
December 2015: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/26437581/innervation-and-neuromuscular-control-in-ageing-skeletal-muscle
#19
Russell T Hepple, Charles L Rice
Changes in the neuromuscular system affecting the ageing motor unit manifest structurally as a reduction in motor unit number secondary to motor neuron loss; fibre type grouping due to repeating cycles of denervation-reinnervation; and instability of the neuromuscular junction that may be due to either or both of a gradual perturbation in postsynaptic signalling mechanisms necessary for maintenance of the endplate acetylcholine receptor clusters or a sudden process involving motor neuron death or traumatic injury to the muscle fibre...
April 15, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/26372620/targeted-muscle-reinnervation-of-the-brachium-an-anatomic-study-of-musculocutaneous-and%C3%A2-radial-nerve-motor-points-relative-to-proximal-landmarks
#20
Christopher H Renninger, Vanna J Rocchi, Leo T Kroonen
PURPOSE: Targeted muscle reinnervation (TMR) offers enhanced prosthetic use by harnessing additional neural control from unused nerves in the amputated limb. The purpose of this study was to document the location and number of motor end plates to each muscle commonly used in TMR in the brachium relative to proximally based bony landmarks. METHODS: We dissected 18 matched upper limbs (9 fresh-frozen cadavers). The locations of each of the nerves' muscular insertions into the medial biceps and brachialis were measured relative to the anterolateral tip of the acromion...
November 2015: Journal of Hand Surgery
keyword
keyword
17387
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"