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https://www.readbyqxmd.com/read/29231594/-regulation-of-acupuncture-on-expression-of-akt-protein-in-lung-tissues-of-asthma-rats
#1
Jinhua Yang, Ye Zhao, Shuang Li, Junping Han, Yueyue Yu, Zhizhong Fan, Huijuan Liu, Jianmei Cui
OBJECTIVE: To explore the effects of acupuncture on the expression of protein kinase B (PKB/AKT) in lung tissues of asthma rats. METHODS: Forty SPF male SD rats were randomly divided into a blank group, a model group, an acupuncture group and a blocker group, 10 rats in each one. The rat model of asthma was established by egg albumin stimulation in the model group, acupuncture group and blocker group. Since the establishment of rat model, the rats in the acupuncture group were treated with acupuncture at "Dazhui" (GV 14), "Feishu" (BL 13) and "Fengmen" (BL 12) before atomization; the rats in the blocker group were treated with intervention of blocker LY294002, once every two days, for 7 times...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231590/-clinical-therapeutic-effect-on-bronchial-asthma-in-children-of-different-body-constitutions-treated-with-sanfu-pingchuan-plaster-and-sanjiu-zhichuan-plaster
#2
Yaning Deng, Hongxin Yang, Min Tang, Peng Wang, Lan Zhang, Yanying Shi
OBJECTIVE: To observe the difference in the clinical therapeutic effects on bronchial asthma in children of different body constitutions treated with sanfu pingchuan plaster and sanjiu zhichuan plaster. METHODS: One hundred and twenty-two children of bronchial asthma were divided into three groups according to TCM body constitutions, 42 cases in the qi deficiency constitution group, 40 cases in the yang deficiency constitution group and 40 cases in the phlegm damp constitution group...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231548/-acupuncture-for-tgf-%C3%AE-1-expression-in-lung-tissues-of-asthma-rats
#3
Junping Han, Shuang Li, Ye Zhao, Jinhua Yang, Yueyue Yu, Na Sun, Jianmei Cui
OBJECTIVE: To explore the regulation of acupuncture for transforming growth factor β1 (TGF-β1) expression in the lung tissues of bronchial asthmatic rats. METHODS: Forty SPF male SD rats were randomly divided into a blank group, a model group, an acupuncture group and a shallow fast acupuncture group, 10 rats in each group. Asthma model was established in the model, acupuncture, and shallow fast acupuncture groups, and no intervention was applied in the blank and model groups...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231494/-optimization-of-acupoint-application-scheme-in-the-treatment-of-bronchial-asthma-based-on-the-orthogonal-design-method
#4
Kuan Shi, Wenzhong Wu, Lanying Liu, Hesheng Wang, Dong Chen, Chengyong Liu, Cong Zhang
OBJECTIVE: To study the primary and secondary factors of the allergic history, the frequency of acupoint application and the time of acupoint application in the treatment of bronchial asthma and optimize its scheme. METHODS: Eighty patients of bronchial asthma were selected as the subjects in the orthogonal trial. The herbal medicines were the empirical formula of acupoint application (prepared at the ratio as 2:2:1:1:1:1:1:1:1 of semen brassicae, rhizome corydalis, unprocessed radix kansui, asarum sieboldii, ephedra, semen lepidii, syzygium aromaticum, cortex cinnamomi and fructus gleditsiae) and used on bilateral Feishu (BL 13), Xinshu (BL 15), Geshu (BL 17) and Shenshu (BL 23)...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29228942/multiple-breath-washout-testing-in-adults-with-pulmonary-disease-and-healthy-controls-can-fewer-measurements-eventually-be-more
#5
Frederik Trinkmann, Johannes Götzmann, Daniel Saur, Michele Schroeter, Katharina Roth, Ksenija Stach, Martin Borggrefe, Joachim Saur, Ibrahim Akin, Julia D Michels
BACKGROUND: Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations prolongs test times. We therefore aimed to evaluate reporting only duplicate measurements in healthy adults and pulmonary disease. METHODS: One hundred and fifty-three subjects prospectively underwent conventional lung function testing and closed-circuit SF6-MBW...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29228529/efficacy-of-bronchial-washing-and-brushing-cytology-in-the-diagnosis-of-non-neoplastic-lung-diseases
#6
Rahil Giti, Massood Hosseinzadeh
Flexible fiberoptic bronchoscopy is often the initial technique for diagnosis of lung and bronchial tumors. Many studies have shown the high accuracy rate of bronchial washing and brushing cytology in the evaluation of neoplastic and non-neoplastic bronchopulmonary lesions. The aim of this study is to emphasize the value of the bronchial cytologic findings for diagnosis of non-neoplastic bronchopulmonary lesions. In a cross-sectional study, we retrieved all cases with bronchial washing and brushing cytology from 21 Mach 2014 to 21 December 2015...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29228412/a-case-of-eosinophilic-myocarditis-associated-with-cardiogenic-shock
#7
Hideki Ozawa, Akiko Taoda, Takuma Shinoda, Hidetaka Yanagi, Masayuki Oki, Atsushi Takagi
The patient was a 32-year-old man with a previous history of bronchial asthma. He was admitted with chief complaints of dyspnea and skin rash associated with itching of the palms and soles of the feet, which began 2 weeks earlier. Because of the presence of cardiac failure and increase in the peripheral blood eosinophil count, eosinophilic myocarditis (EM) was suspected. His blood pressure gradually decreased and the patient went into cardiogenic shock. Therefore, endomyocardial biopsy was performed and was immediately followed by corticosteroid therapy and intra-aortic balloon pump (IABP) placement...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/29227262/-combined-course-of-bronchial-asthma-and-gastroesophageal-reflux-disease-its-clinical-functional-peculiarities-and-mechanisms-of-its-correction
#8
M Derbak, O Boldizhar, Ye Sirchak, Ya Lazur, M Aleksandrova
The combined course of bronchial asthma (BA) and digestive system pathology is one of the most frequent, severe and clinically varied pathology. The purpose of the paper - to study the influence of gastroesophageal reflux disease (GERD) on the course of BA and the effectiveness of antireflux therapy in combined pathology. Patients with combined pathology were treated in full-time department more frequently than patients with isolated BA (3,4±0,5 per year to - 1,8±0,3; р<0,05). The statistically reliable correlation between frequency of heartburn and frequency of cough, which goes over to asthma attacks was observed (r=0,59; р<0,05)...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29221918/low-variability-in-peak-expiratory-flow-predicts-successful-inhaled-corticosteroid-step-down-in-adults-with-asthma
#9
Naomi Tsurikisawa, Chiyako Oshikata, Toshio Sato, Goro Kimura, Masami Mizuki, Takahiro Tsuburai, Shunsuke Shoji, Hiroshi Saito, Terufumi Shimoda
BACKGROUND: The prognosis for patients beyond 1 year after reduction of their inhaled corticosteroid (ICS) dose remains unknown. Predictive factors that can be evaluated before the initiation of asthma treatment or at ICS dose reduction are unknown. METHODS: We prospectively studied 223 patients in 6 hospitals in the National Hospital Organization of Japan during the 36 months after 50% reduction of their daily ICS dose. All patients recorded their morning and evening peak expiratory flows (PEFs) in their diaries...
December 5, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29221262/differences-in-airway-remodeling-and-airway-inflammation-among-moderate-severe-asthma-clinical-phenotypes
#10
Wen-Jing Ye, Wei-Guo Xu, Xue-Jun Guo, Feng-Feng Han, Juan Peng, Xiao-Ming Li, Wen-Bin Guan, Li-Wei Yu, Jin-Yuan Sun, Zhi-Lei Cui, Lin Song, Yue Zhang, Yan-Min Wang, Tian-Yun Yang, Xia-Hui Ge, Di Yao, Song Liu
Background: To identify asthma clinical phenotypes using cluster analysis and improve our understanding of heterogeneity in asthma. Methods: Clustering approaches were applied to 203 patients who were diagnosed with asthma in XinHua Hospital (January 2012 to December 2015). One hundred and twenty patients underwent multi-slice spiral computed tomography (MSCT) examination and 30 underwent bronchial mucosal biopsy for evaluation of airway remodeling and airway inflammation among the phenotypes...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220595/dose-dependent-effects-of-tadalafil-and-roflumilast-on-ovalbumin-induced-airway-hyperresponsiveness-in-guinea-pigs
#11
Anna Urbanova, Ivana Medvedova, Martin Kertys, Pavol Mikolka, Petra Kosutova, Daniela Mokra, Juraj Mokrý
INTRODUCTION: Chronic obstructive diseases of airways associated with cough and/or airway smooth muscle hyperresponsiveness are usually treated with bronchodilating and anti-inflammatory drugs. Recently, selective phosphodiesterase (PDE) 4 inhibitors have been introduced into the therapy of chronic obstructive pulmonary disease. Several studies have demonstrated their ability to influence the airway reactivity and eosinophilic inflammation by increasing the intracellular cAMP concentrations also in bronchial asthma...
December 8, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29217995/the-alteration-of-irisin-brain-derived-neurotrophic-factor-axis-parallels-severity-of-distress-disorder-in-bronchial-asthma-patients
#12
Magdolna E Szilasi, Krisztian Pak, Laszlo Kardos, Viktoria E Varga, Ildiko Seres, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Gabor Tajti, Csaba Papp, Rudolf Gesztelyi, Judit Zsuga
Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma. The irisin-brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of distress disorder. Thus, the aim of the present study was to quantify the serum irisin and BDNF concentrations in order to investigate the possible link between the irisin/BDNF axis and distress disorder in an asthma patient cohort...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29211208/accuracy-of-spirometry-for-detection-of-asthma-a-cross-sectional-study
#13
Andréa Cristina Meneghini, Ana Carolina Botto Paulino, Luciano Penha Pereira, Elcio Oliveira Vianna
BACKGROUND: Asthma is a chronic inflammatory disease with airway hyperresponsiveness. Spirometry is the most commonly used test among asthmatic patients. Another functional test used for diagnosing asthma is the bronchial challenge test. The aim of this study was to analyze the accuracy of spirometry for detecting asthma in the general population. DESIGN AND SETTING: Cross-sectional study with data analysis to evaluate the accuracy of spirometry through calculating sensitivity, specificity and predictive values and through the kappa agreement test...
September 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29210131/allergens-produce-serine-proteases-dependent-distinct-release-of-metabolite-damps-in-human-bronchial-epithelial-cells
#14
Sangeetha Ramu, Mandy Menzel, Leif Bjermer, Cecilia Andersson, Hamid Akbarshahi, Lena Uller
BACKGROUND: The respiratory epithelium is a major site for disease interaction with inhaled allergens. Additional to IgE-dependent effects, allergens contain proteases that may stimulate human bronchial epithelial cells (HBECs) through protease-activated receptors, causing the release of mediators important in driving Th2 mediated immune responses. OBJECTIVE: We aimed to investigate if different allergens induce metabolite DAMPs such as ATP and uric acid (UA) release in HBECs...
December 6, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29209456/novel-glutathione-containing-dry-yeast-extracts-inhibit-eosinophilia-and-mucus-overproduction-in-a-murine-model-of-asthma
#15
Yun-Ho Kim, Yean-Jung Choi, Eun-Jung Lee, Min-Kyung Kang, Sin-Hye Park, Dong Yeon Kim, Hyeongjoo Oh, Sang-Jae Park, Young-Hee Kang
BACKGROUND/OBSECTIVE: Airway inflammation by eosinophils, neutrophils and alveolar macrophages is a characteristic feature of asthma that leads to pathological subepithelial thickening and remodeling. Our previous study showed that oxidative stress in airways resulted in eosinophilia and epithelial apoptosis. The current study investigated whether glutathione-containing dry yeast extract (dry-YE) ameliorated eosinophilia, goblet cell hyperplasia and mucus overproduction. MATERIALS/METHOD: This study employed 2 µg/mL lipopolysaccharide (LPS)- or 20 ng/mL eotaxin-1-exposed human bronchial epithelial cells and ovalbumin (OVA)-challenged mice...
December 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29208876/disease-pattern-among-children-attending-pediatric-outpatient-department-in-community-based-medical-college-hospital-bangladesh
#16
M Begum, M K Khan, M T Hossain, M Y Ali, F S Alam, S S Dipu, A H Hasan, M Nasrin
Disease pattern is based on socio-demographic characteristics, comprehensive health care services, and environmental variables like water supply, basic sanitation and housing, illness behavior like quick decision to arrive at health care facility, and treatment behavior like the modality of treatment they receive. The descriptive cross-sectional study was conducted during the period of January 2014 to December 2015. The study was carried out among 310 purposively selected children attended at Pediatric Outpatient department of Community Based Medical College Hospital, Bangladesh...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207992/correction-to-chronic-obstructive-pulmonary-disease-bronchial-asthma-and-allergic-rhinitis-in-the-adult-population-within-the-commonwealth-of-independent-states-rationale-and-design-of-the-core-study
#17
Yuriy Feshchenko, Liudmyla Iashyna, Damilya Nugmanova, Olga Gyrina, Maryna Polianska, Alexander Markov, Maryna Moibenko, Janina Makarova, Luqman Tariq, Marcelo Horacio S Pereira, Eljan Mammadbayov, Irada Akhundova, Averyan Vasylyev
After publication of this work [1] it was noticed three author names were spelt incorrectly. Liudmila Iashyna should be Liudmyla Iashyna, Marina Polyanskaya should be Maryna Polianska and Elcan Mamamdbayov should be Eljan Mammadbayov.
December 5, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29207033/epigallocatechin-3-gallate-inhibits-inflammation-and-epithelial%C3%A2-mesenchymal-transition-through-the-pi3k-akt-pathway-via-upregulation-of-pten-in-asthma
#18
Nan Yang, Han Zhang, Xuxu Cai, Yunxiao Shang
Asthma is a chronic disease associated with hyperresponsiveness, obstruction and remodeling of the airways. Epithelial-mesenchymal transition (EMT) has an important role in these alterations and may account for the accumulation of subepithelial mesenchymal cells, thus contributing to airway hyperresponsiveness and remodeling. Epigallo-catechin‑3‑gallate (EGCG), which is a type of polyphenol, is the most potent ingredient in green tea, and exhibits antibacterial, antiviral, antioxidative, anticancer and chemopreventive activities...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29207030/der-f1-induces-pyroptosis-in-human-bronchial-epithelia-via-the-nlrp3-inflammasome
#19
Ying-Ming Tsai, Kuo-Hwa Chiang, Jen-Yu Hung, Wei-An Chang, Hui-Ping Lin, Jiunn-Min Shieh, Inn-Wen Chong, Ya-Ling Hsu
Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase release and propidium iodide penetration...
December 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29204432/caspase-1-deficiency-reduces-eosinophilia-and-interleukin-33-in-an-asthma-exacerbation-model
#20
Mandy Menzel, Hamid Akbarshahi, Irma Mahmutovic Persson, Manoj Puthia, Leif Bjermer, Lena Uller
Rhinovirus infections are common triggers of asthma exacerbations. Viruses can activate the inflammasome, resulting in processing and activation of caspase-1. This recruitment triggers production of interleukin (IL)-1β and IL-18, which have been implicated in asthma. Elucidating the involvement of the inflammasome and its compartments, such as caspase-1, in asthma exacerbations is warranted. Gene expression of caspase-1 was measured in rhinovirus-infected primary bronchial epithelial cells of asthmatic and healthy donors 24 h post-infection...
October 2017: ERJ Open Research
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