Angela Kim, Jakob G Knudsen, Joseph C Madara, Anna Benrick, Thomas Hill, Lina Abdul-Kadir, Joely A Kellard, Lisa Mellander, Caroline Miranda, Haopeng Lin, Timothy James, Kinga Suba, Aliya F Spigelman, Yanling Wu, Patrick E Macdonald, Ingrid Wernstedt Asterholm, Tore Magnussen, Mikkel Christensen, Tina Visboll, Victoria Salem, Filip K Knop, Patrik Rorsman, Bradford B Lowell, Linford Jb Briant
Insulin-induced hypoglycemia is a major barrier to the treatment of type-1 diabetes (T1D). Accordingly, it is important that we understand the mechanisms regulating the circulating levels of glucagon - the body's principal blood glucose-elevating hormone which is secreted from alpha-cells of the pancreatic islets. Varying glucose over the range of concentrations that occur physiologically between the fed and fuel-deprived states (from 8 to 4 mM) has no significant effect on glucagon secretion in the perfused mouse pancreas or in isolated mouse islets ( in vitro ) and yet associates with dramatic changes in plasma glucagon in vivo ...
November 17, 2021: ELife