Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M Nicoloro, Mark Kelly, Lawrence M Lifshitz, Hui Wang, Kyounghee Min, Leslie A Rowland, Kaltinaitis B Santos, Nicole Wetoska, Randall H Friedline, Stacy A Maitland, Min Chen, Lee S Weinstein, Scot A Wolfe, Jason K Kim, Michael P Czech
OBJECTIVES: Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled respiration in mouse and human adipocytes. We tested whether NRIP1 deficient adipocytes implanted into obese mice would enhance whole body metabolism. Since β-adrenergic signaling through cAMP strongly promotes adipocyte thermogenesis, we tested whether the effects of Nrip1KO require the cAMP pathway. METHODS: NRIP1KO adipocytes were implanted in recipient HFD fed mice and metabolic cage studies conducted...
July 22, 2023: Molecular Metabolism