keyword
MENU ▼
Read by QxMD icon Read
search

Insulin receptor implantation

keyword
https://www.readbyqxmd.com/read/29726999/insulin-regulates-glycogen-synthesis-in-human-endometrial-glands-through-increased-gys2
#1
Clare A Flannery, Gina H Choe, Andrew G Fleming, Katherine M Cooke, Caitlin C Radford, Pinar H Kodaman, Michael J Jurczak, Richard G Kibbey, Hugh S Taylor
Context: Glycogen synthesis is a critical metabolic function of the endometrium to prepare for successful implantation and sustain embryo development. Yet regulation of endometrial carbohydrate metabolism is poorly characterized. While glycogen synthesis is attributed to progesterone, we previously found that the metabolic B isoform of insulin receptor is maximally expressed in secretory phase endometrium indicating a potential role of insulin in glucose metabolism. Objective: We sought to determine whether insulin or progesterone regulates glycogen synthesis in human endometrium...
May 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29472733/androgen-interacts-with-exercise-through-the-mtor-pathway-to-induce-skeletal-muscle-hypertrophy
#2
Fanxing Zeng, Hua Zhao, Jingwen Liao
This study was designed to investigate the effects of exogenous androgen and resistance exercise on skeletal muscle hypertrophy and the role of the mammalian target of rapamycin (mTOR) signalling during the process. A total of 24 male Sprague-Dawley rats were randomly assigned to sham operation and dihydrotestosterone (DHT) implantation groups with subgroups subjected to sedentary conditions or resistance exercise (SHAM+SED, SHAM+EX, DHT+SED, and DHT+EX). The experimental procedure lasted for 10 days. The mRNA expression of androgen receptor (AR) and insulin-like growth factor I (IGF-I), the expression of myosin heavy chain (MHC), as well as the phosphorylation statuses of AR, mTOR, p70 ribosomal S6 kinase (p70S6K ), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) were determined in the white gastrocnemius muscle...
December 2017: Biology of Sport
https://www.readbyqxmd.com/read/29421366/chronic-administration-of-morphine-using-mini-osmotic-pumps-affects-spatial-memory-in-the-male-rat
#3
Erika Brolin, Sofia Zelleroth, Anna Jonsson, Mathias Hallberg, Alfhild Grönbladh, Fred Nyberg
The use of opioid analgesics to treat non-cancer pain has increased over the years. Many chronic pain patients suffer from numerous adverse effects, such as reduced quality of life, development of dependence, and cognitive impairments. Cognitive processes are regulated by several systems, one of which involves growth hormone (GH) and its secondary mediator insulin-like growth factor-1 (IGF-1), but also glutamatergic transmission, including receptors such as the N-methyl-d-aspartate (NMDA)-receptor complex. In the laboratory, repeated injections are commonly used to establish animal models of long-term or chronic drug exposure...
April 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29412837/glucose-lowering-therapies-in-type-2-diabetes-opportunities-and-challenges-for-peptides
#4
REVIEW
Clifford J Bailey
This overview considers the opportunities and challenges that face the use of gluco-regulatory peptides to treat type 2 diabetes. New insulin analogues and formulations are being developed with pharmacokinetic properties to speed-up or prolong transfer from a subcutaneous injection site to the target tissues, or to selectively favour effects on the liver. Alternative routes of insulin administration continue to attract attention, and advances in the integration of glucose monitoring with insulin pump devices are improving miniaturised 'closed loop' artificial pancreas systems...
February 2018: Peptides
https://www.readbyqxmd.com/read/29365042/elevated-androgen-levels-induce-hyperinsulinemia-through-increase-in-ins1-transcription-in-pancreatic-beta-cells-in-female-rats
#5
Jay S Mishra, Amar S More, Sathish Kumar
Hyperandrogenism is associated with hyperinsulinemia and insulin resistance in adult females. We tested whether androgens dysregulate pancreatic beta cell function to induce hyperinsulinemia through transcriptional regulation of insulin gene (Ins) in the islets. Adult female Wistar rats implanted with dihydrotestosterone (DHT; 7.5-mg, 90-d release) or placebo pellets were examined after 10 weeks. DHT exposure increased plasma DHT levels by 2-fold similar to that in polycystic ovary syndrome in women. DHT exposure induced hyperinsulinemia with increased HOMA-IR index in fasting state and glucose intolerance and exaggerated insulin responses following glucose tolerance test...
January 22, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29330027/selective-estrogen-receptor-modulator-ormeloxifene-suppresses-embryo-implantation-via-inducing-mir-140-and-targeting-insulin-like-growth-factor-1-receptor-in-rat-uterus
#6
Vijay Kumar Sirohi, Kanchan Gupta, Rohit Kumar, Vinay Shukla, Anila Dwivedi
Ormeloxifene, the non-steroidal SERM contraceptive, inhibits endometrial receptivity and embryo implantation via countering nidatory estrogen. However, the molecular mechanism of ormeloxifene action responsible for its contraceptive efficacy still remains unclear. Herein, we aimed to identify the miRNAs modulated under the influence of ormeloxifene and to explore their role in endometrial receptivity and embryo implantation. By doing microRNA sequencing analysis, a total of 168 miRNAs were found to be differentially expressed in uterine tissue of ormeloxifene-treated rats, on day 5 (10:00 h) of pregnancy i...
April 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29210631/uterine-function-from-normal-to-polycystic-ovarian-syndrome-alterations
#7
Silvana R Ferreira, Alicia B Motta
BACKGROUND: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. METHODS: We conducted a search at the http://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress...
2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28911214/growth-regulation-by-estrogen-in-breast-cancer-1-greb1-is-a-novel-progesterone-responsive-gene-required-for-human-endometrial-stromal-decidualization
#8
Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani
STUDY QUESTION: Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? SUMMARY ANSWER: GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. WHAT IS KNOWN ALREADY: Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28810880/nlrp7-contributes-to-in-vitro-decidualization-of-endometrial-stromal-cells
#9
Jyun-Yuan Huang, Pei-Hsiu Yu, Yueh-Chun Li, Pao-Lin Kuo
BACKGROUND: Nucleotide-binding oligomerization domain (NACHT), leucine rich repeat (LRR) and pyrin domain (PYD) 7 containing protein, NLRP7, is a member of the NLR family which serves as innate immune sensors. Mutations and genetic variants of NLRP7 have been found in women with infertility associated conditions, such as recurrent hydatidiform mole, recurrent miscarriage, and preeclampsia. Decidualization of endometrial stromal cells is a hallmark of tissue remodeling to support embryo implantation and proper placental development...
August 15, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28761132/exendin-4-reduces-food-intake-via-the-pi3k-akt-signaling-pathway-in-the-hypothalamus
#10
Yan Yang, Pique P Choi, Wanli W Smith, Weijie Xu, Delin Ma, Zachary A Cordner, Nu-Chu Liang, Timothy H Moran
Exendin-4 (EX-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake and to increase proopiomelanocortin (POMC) gene expression in the hypothalamus. In this study, we examined the potential neural mechanisms by which these effects occur. Male Sprague Dawley rats were implanted with a cannula in the third ventricle of the brain through which an inhibitor of phosphatidylinositol-3 kinase (PI3K) (wortmannin) was administered, and EX-4 or vehicle was administered via intraperitoneal (IP) injection...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28758253/mir-182-selectively-targets-hoxa10-in-goat-endometrial-epithelium-cells-in-vitro
#11
L Zhang, X-R Liu, J-Z Liu, Y-X Song, Z-Q Zhou, B-Y Cao
Proper HOXA10 expression was essential for endometrial receptivity what was crucial for successful embryo implantation in mammalian. This study confirmed that miR-182 regulated the expression levels of HOXA10 by binding to its 3' UTR, selectively downregulated HOXA10 in goat endometrial epithelium cells (gEECs) but not stromal cell (gESCs) in vitro. However, HOXA10 and miR-182 both up-expressed in the goat endometrium at gestational day 15 (D15) compared with gestational day 5 (D5), suggesting that there were some other factors regulated the expression of HOXA10 during the development of goat endometrium in vivo...
July 30, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28739528/chronic-hyper-leptinemia-induces-insulin-signaling-disruption-in-adipocytes-implications-of-nos2
#12
Abhishek Gupta, Muheeb Beg, Durgesh Kumar, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Kalpana Singh, Satyendra Sonkar, Abbas Ali Mahdi, Madhu Dikshit, Anil Nilkanth Gaikwad
Leptin, following its discovery, has developed a formidable interest in the scientific community to delineate its contribution towards overall metabolic homeostasis. Contradictory reports have been published on leptin administration effects on whole body insulin sensitivity. Following late reports, we surveyed human serum leptin levels along with other metabolic parameters including BMI and HOMA-IR. We found a positive correlation between leptin levels and insulin resistance parameters. Considering the presence of the long form of leptin receptor on adipocytes, we explored the effects of chronic physiological hyper-leptinemic exposure on adipocyte insulin sensitivity...
July 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28733350/adiponectin-limits-differentiation-and-trophoblast-invasion-in-human-endometrial-cells
#13
Fabien Duval, Esther Dos Santos, Hadia Moindjie, Valérie Serazin, Nelly Swierkowski-Blanchard, François Vialard, Marie-Noëlle Dieudonné
Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1), and connexin-43. Decidual cells are also involved in the control of trophoblast invasion, by secreting various factors, as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Adiponectin is an adipokine with insulin-sensitizing, anti-inflammatory, and anti-proliferative effects...
July 21, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28447735/mice-endometrium-receptivity-in-early-pregnancy-is-impaired-by-maternal-hyperinsulinemia
#14
Runqin Li, Juan Wu, Junlin He, Yingxiong Wang, Xueqing Liu, Xuemei Chen, Chao Tong, Yubin Ding, Yan Su, Wenqi Chen, Chen Zhang, Rufei Gao
Previous studies have investigated the lower embryo implantation rates in women with polycystic ovary syndrome, obesity and type 2 diabetes, and specifically the association between the abnormal oocyte and embryo and hyperinsulinemia. The importance of hyperinsulinemia on maternal endometrium receptivity remains to be elucidated. The present study used a hyperinsulinemic mouse model to determine whether hyperinsulinemia may affect endometrial receptivity. An insulin intervention mouse model was first established...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28396510/in-vivo-enrichment-of-diabetogenic-t-cells
#15
Martin A Thelin, Stephan Kissler, Frederic Vigneault, Alexander L Watters, Des White, Sandeep T Koshy, Sarah A Vermillion, David J Mooney, Thomas Serwold, Omar A Ali
Dysfunctional T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of autoimmune T cells in the blood hinder their study. We describe a method to enrich and harvest autoimmune T cells in vivo by using a biomaterial scaffold loaded with protein antigens. In model antigen systems, we found that antigen-specific T cells become enriched within scaffolds containing their cognate antigens. When scaffolds containing lysates from an insulin-producing β-cell line were implanted subcutaneously in autoimmune diabetes-prone NOD mice, β-cell-reactive T cells homed to these scaffolds and became enriched...
August 2017: Diabetes
https://www.readbyqxmd.com/read/28336389/metformin-ameliorates-uterine-defects-in-a-rat-model-of-polycystic-ovary-syndrome
#16
Yuehui Zhang, Min Hu, Fanci Meng, Xiaoyan Sun, Hongfei Xu, Jiao Zhang, Peng Cui, Njomeza Morina, Xin Li, Wei Li, Xiao-Ke Wu, Mats Brännström, Ruijin Shao, Håkan Billig
Adult rats treated concomitantly with insulin and human chorionic gonadotropin exhibit endocrine, metabolic, and reproductive abnormalities that are very similar to those observed in polycystic ovary syndrome (PCOS) patients. In this study, we used this rat model to assess the effects of metformin on PCOS-related uterine dysfunction. In addition to reducing androgen levels, improving insulin sensitivity, and correcting the reproductive cycle, metformin treatment induced morphological changes in the PCOS-like uterus...
April 2017: EBioMedicine
https://www.readbyqxmd.com/read/28259137/chronic-endometritis-modifies-decidualization-in-human-endometrial-stromal-cells
#17
Di Wu, Fuminori Kimura, Luyi Zheng, Mitsuaki Ishida, Yoko Niwa, Kimiko Hirata, Akie Takebayashi, Akiko Takashima, Kentaro Takahashi, Ryoji Kushima, Guangmei Zhang, Takashi Murakami
BACKGROUND: Chronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, its significance has not been explored. However, recent studies have shown that CE is related with repeated implantation failures after in vitro fertilization-embryo transfer, unexplained infertility, and recurrent miscarriages. As decidua differentiates to support the implantation process and maintains the pregnancy, we hypothesized that CE may influence the process of decidualization...
March 4, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28092845/cinnamaldehyde-potentially-attenuates-gestational-hyperglycemia-in-rats-through-modulation-of-ppar%C3%AE-proinflammatory-cytokines-and-oxidative-stress
#18
Ahmed A Hosni, A Adel Abdel-Moneim, Eman S Abdel-Reheim, Samah M Mohamed, Hamdi Helmy
Cinnamon has a history of use for medicinal purposes and its major benefits have been linked to cinnamaldehyde. The present study aimed to investigate the hypoglycemic action of cinnamaldehyde against fatty-sucrosed diet/streptozotocin (FSD/STZ)-rat model of gestational diabetes. Female albino rats were divided into three groups. Group I fed with normal diet (ND) while group II and III were fed with FSD for eight weeks (five weeks pre-gestational and three weeks gestational). Rats of group III were administered with a daily oral dose of 20mg/kg cinnamaldehyde one week before mating onward...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28063235/a-critical-role-for-adiponectin-mediated-development-of-endometrial-luminal-epithelial-cells-during-the-peri-implantation-period-of-pregnancy
#19
Whasun Lim, Myung Jin Choi, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
Adiponectin is one of the adipokines in the collagen superfamily. It is secreted primarily by white adipocytes and influences reproductive processes including ovarian and uterine functions. Adiponectin regulates energy homeostasis, insulin sensitivity, and is anti-inflammatory in various tissues. Its receptors (ADIPOR1 and ADIPOR2) are widely expressed in mammalian tissues, including porcine conceptuses and endometrial during the estrous cycle and peri-implantation period of pregnancy. However, regulatory effects of adiponectin on endometrial epithelial cells are unknown...
November 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27984270/bitter-melon-extract-promotes-granulation-tissue-growth-and-angiogenesis-in-the-diabetic-wound
#20
COMPARATIVE STUDY
Rekha Singh, Ignacio Garcia-Gomez, Krishnamurthy P Gudehithlu, Ashok K Singh
OBJECTIVE: Bitter melon is a plant fruit that has been shown to exert a hypoglycemic effect when used systemically in patients with diabetes. This study was designed to investigate the topical effect of bitter melon on diabetic wounds using the wound chamber model in rats. DESIGN: Two bilateral wound chambers were implanted subcutaneously in the thoracic-lumbar region of male Sprague-Dawley rats. Diabetes was induced with streptozotocin 7 days after implantation of wound chambers...
January 2017: Advances in Skin & Wound Care
keyword
keyword
17380
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"