keyword
Keywords Umbilical cord Mesenchymal ste...

Umbilical cord Mesenchymal stem cells

https://read.qxmd.com/read/38443965/amelioration-of-diabetic-nephropathy-in-mice-by-a-single-intravenous-injection-of-human-mesenchymal-stromal-cells-at-early-and-later-disease-stages-is-associated-with-restoration-of-autophagy
#21
JOURNAL ARTICLE
Jingjing He, Boxin Liu, Xiaofeng Du, Yan Wei, Desheng Kong, Baofeng Feng, Ruiyun Guo, Ernest Amponsah Asiamah, Matthew D Griffin, Sean O Hynes, Sanbing Shen, Yan Liu, Huixian Cui, Jun Ma, Timothy O'Brien
BACKGROUND AND AIMS: Mesenchymal stromal cells (MSCs) a potentially effective disease-modulating therapy for diabetic nephropathy (DN) but their clinical translation has been hampered by incomplete understanding of the optimal timing of administration and in vivo mechanisms of action. This study aimed to elucidate the reno-protective potency and associated mechanisms of single intravenous injections of human umbilical cord-derived MSCs (hUC-MSCs) following shorter and longer durations of diabetes...
March 5, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38442726/bioreactor-based-stem-cell-therapy-for-liver-fibrosis
#22
JOURNAL ARTICLE
Mengchao Yan, Jia Yao, Ye Xie, Pan Jiang, Jun Yan, Xun Li
Stem cell therapy, achieved using mesenchymal stem cells (MSCs), has been highlighted for the treatment of liver fibrosis. Infusion into the circulatory system is a traditional application of MSCs; however, this approach is limited by phenotypic drift, stem cell senescence, and vascular embolism. Maintaining the therapeutic phenotype of MSCs while avoiding adverse infusion-related reactions is the key to developing next-generation stem cell therapy technologies. Here, we propose a bioreactor-based MSCs therapy to avoid cell infusion...
March 5, 2024: Biofabrication
https://read.qxmd.com/read/38438896/transplantation-of-the-lrp1-high-subpopulation-of-human-umbilical-cord-derived-mesenchymal-stem-cells-improves-ovarian-function-in-mice-with-premature-ovarian-failure-and-aged-mice
#23
JOURNAL ARTICLE
Jiacheng Shen, Li Wu, Xiaoying Shi, Gang Chen, Tingwei Liu, Fangfang Xu, Xiaocui Xu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Chenfei Wang, Shaorong Gao, Shaohua Xu
BACKGROUND: Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demonstrated unprecedented potential in the treatment of POF. However, the heterogeneity of human UC-MSCs remains a challenge for their large-scale clinical application. Therefore, it is imperative to identify specific subpopulations within UC-MSCs that possess the capability to improve ovarian function, with the aim of reducing the uncertainty arising from the heterogeneity while achieving more effective treatment of POF...
March 5, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38436082/co-transplantation-of-umbilical-cord-mesenchymal-stem-cells-and-peripheral-blood-stem-cells-in-children-and-adolescents-with-refractory-or-relapsed-severe-aplastic-anemia
#24
JOURNAL ARTICLE
Fangfang Yuan, Minghui Li, Xudong Wei, Yuewen Fu
To evaluate the co-transplantation efficacy of umbilical cord mesenchymal stem cells (UC-MSCs) and peripheral blood stem cells (PBSCs) as a novel approach for refractory or relapsed severe aplastic anemia (R/R SAA) in children and adolescents, thirty-two children and adolescents diagnosed with R/R SAA underwent a retrospective chart review. The patients were categorized into two groups based on the source of PBSCs: the matched sibling donor (MSD) group and the unrelated donor (UD) group. No adverse events related to UC-MSC infusion occurred in any of the patients...
March 4, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38435131/extracellular-vesicles-ameliorates-sleep-deprivation-induced-anxiety-like-behavior-and-cognitive-impairment-in-mice
#25
JOURNAL ARTICLE
Yiqin Lin, Zhenming Kang, Changsheng Su, Shunyuan Li, Wenqin Xie
The aim of this research was to explore the therapeutic capabilities of extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) that had been subjected to heat shock pretreatment, in treating psychiatric disorders induced by sleep deprivation in mice. The EVs were isolated and characterized, while western blotting was utilized to assess the expression of exosomal markers and heat shock protein 70 (HSP70). To evaluate the impact of EV treatment on anxiety-like behavior and cognitive impairment in sleep-deprived (SD) mice, the open field test, plus maze test, and Y-maze task were conducted...
March 14, 2024: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/38433020/human-umbilical-cord-mesenchymal-stem-cells-reverse-depression-in-rats-induced-by-chronic-unpredictable-mild-stress-combined-with-lipopolysaccharide
#26
JOURNAL ARTICLE
Pengxiang Wang, Yunxia Li, Yongli Song, Yuan Gao, Chunxia Hao, Yang Zhou, Siqin Bao, Jitong Guo, Xihe Li
BACKGROUND: Inflammation and oxidative stress are considered crucial to the pathogenesis of depression. Rat models of depression can be created by combined treatments of chronic unpredictable mild stress (CUMS) and lipopolysaccharide (LPS). Behaviors associated with depression could be improved by treatment with mesenchymal stem cells (MSCs) owing to immunomodulatory functions of the cells. Therapeutic potentials of the MSCs to reverse pro-inflammatory cytokines, proteins, and metabolites were identified by transcriptomic, proteomic, and metabolomic analysis, respectively...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38429490/publisher-correction-allogeneic-umbilical-cord-blood-derived-mesenchymal-stem-cell-implantation-versus-microdrilling-combined-with-high-tibial-osteotomy-for-cartilage-regeneration
#27
Se-Han Jung, Bum-Joon Nam, Chong-Hyuk Choi, Sungjun Kim, Min Jung, Kwangho Chung, Jisoo Park, Youngsu Jung, Sung-Hwan Kim
No abstract text is available yet for this article.
March 1, 2024: Scientific Reports
https://read.qxmd.com/read/38426617/implantation-of-hucb-mscs-generates-greater-hyaline-type-cartilage-than-microdrilling-combined-with-high-tibial-osteotomy
#28
JOURNAL ARTICLE
Se-Han Jung, Hyunjin Park, Min Jung, Kwangho Chung, Sungjun Kim, Hyun-Soo Moon, Jisoo Park, Ju-Hyung Lee, Chong-Hyuk Choi, Sung-Hwan Kim
PURPOSE: To compare the outcomes of treating large cartilage defects in knee osteoarthritis using human allogeneic umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation or arthroscopic microdrilling as a supplementary cartilage regenerative procedure combined with high tibial osteotomy (HTO). METHODS: This 1-year prospective comparative study included 25 patients with large, near full-thickness cartilage defects (International Cartilage Repair Society grade ≥ IIIB) in the medial femoral condyles and varus malalignment...
March 1, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
https://read.qxmd.com/read/38421574/preclinical-assessments-of-safety-and-tumorigenicity-of-very-high-doses-of-allogeneic-human-umbilical-cord-mesenchymal-stem-cells
#29
JOURNAL ARTICLE
Sze-Piaw Chin, Nik Syazana Saffery, Kong-Yong Then, Soon-Keng Cheong
Human umbilical cord-mesenchymal stem cells (hUC-MSCs) have been widely investigated as a new therapeutic agent to treat injuries and inflammatory-mediated and autoimmune diseases. Previous studies have reported on the safety of low-dose infusion of hUC-MSCs, but information on the cell behaviour at higher doses and frequency of injection of the cells remains uncertain. The aim of the present study was to demonstrate the safety and efficacy of hUC-MSCs by Cytopeutics® (Selangor, Malaysia) from low to an extremely high dose in different monitoring periods in healthy BALB/c mice as well as assessing the tumorigenicity of the cells in B-NDG SCID immunocompromised mice...
February 29, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38420823/the-role-of-the-notch-signaling-pathway-in-the-differentiation-of-human-umbilical-cord-derived-mesenchymal-stem-cells
#30
REVIEW
Wanhong Xing, Jianxin Yang, Ying Zheng, Lin Yao, Xin Peng, Yongqiang Chen, Chao Yang
Human umbilical cord mesenchymal stem cells (hUCMSCs) exhibit potent self-renewal and multilineage differentiation characteristics. They have garnered substantial attention within the domain of regenerative medicine owing to their therapeutic potential, such as in tissue repair, regeneration, immunomodulation, anti-inflammation, angiogenesis, wound healing, neuroprotection, and neuroregeneration. The process of fate determination is initiated by multiple signaling molecules. During development and tissue homeostasis, the Notch signaling pathway assumes a pivotal function in cell differentiation and the renewal of stem cells...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38415316/early-delivery-of-human-umbilical-cord-mesenchymal-stem-cells-improves-healing-in-a-rat-model-of-achilles-tendinopathy
#31
JOURNAL ARTICLE
Ze Yuan, Ding Yu, Yanxue Wang, Lijiaqi Liu, Junchao Wang, Chao Ma, Shaoling Wu
Objective: This study aimed to explore the efficacy and optimal delivery time of human umbilical cord mesenchymal stem cells (hUC-MSCs) in treating collagenase-induced Achilles tendinopathy. Methods: Achilles tendinopathy in rats at early or advanced stages was induced by injecting collagenase I into bilateral Achilles tendons. A total of 28 injured rats were injected with a hUC-MSC solution or normal saline into bilateral tendons twice and sampled after 4 weeks for histological staining, gene expression analysis, transmission electron microscope assay and biomechanical testing analysis...
February 28, 2024: Regenerative Medicine
https://read.qxmd.com/read/38414067/impact-of-tissue-factor-expression-and-administration-routes-on-thrombosis-development-induced-by-mesenchymal-stem-stromal-cell-infusions-re-evaluating-the-dogma
#32
JOURNAL ARTICLE
Van T Hoang, Duc Son Le, Duc M Hoang, Trang Thi Kieu Phan, Lan Anh Thi Ngo, Trung Kien Nguyen, Viet Anh Bui, Liem Nguyen Thanh
BACKGROUND: Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extrinsic coagulation pathway, has been suggested as a predictor of this process. METHODS: The expression of TF and other pro- and anticoagulant genes was analyzed in xeno- and serum-free manufactured MSCs. Furthermore, culture factors affecting its expression in MSCs were investigated...
February 27, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38403446/a-highly-sensitive-and-specific-homo1-based-real-time-qpcr-method-for-quantification-of-human-umbilical-cord-mesenchymal-stem-cells-in-rats
#33
JOURNAL ARTICLE
Jing He, Zhangfan Wang, Chunchun Ao, Chengshu Tu, Yaqi Zhang, Cheng Chang, Cuihong Xiao, E Xiang, Wei Rao, Changyong Li, Dongcheng Wu
BACKGROUND: Owing to the characteristics of easier access in vitro, low immunogenicity, and high plasticity, human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are considered as a promising cell-based drugs for clinical application. No internationally recognized technology exists to evaluate the pharmacokinetics and distribution of cell-based drugs in vivo. METHODS: We determined the human-specific gene sequence, Homo1, from differential fragments Homo sapiens mitochondrion and Rattus norvegicus mitochondrion...
February 2024: Biotechnology Journal
https://read.qxmd.com/read/38403241/stem-cells-in-regenerative-dentistry-current-understanding-and-future-directions
#34
REVIEW
Pooja Shah, Marziyeh Aghazadeh, Sheeja Rajasingh, Douglas Dixon, Vinay Jain, Johnson Rajasingh
BACKGROUND: Regenerative dentistry aims to enhance the structure and function of oral tissues and organs. Modern tissue engineering harnesses cell and gene-based therapies to advance traditional treatment approaches. Studies have demonstrated the potential of mesenchymal stem cells (MSCs) in regenerative dentistry, with some progressing to clinical trials. This review comprehensively examines animal studies that have utilized MSCs for various therapeutic applications. Additionally, it seeks to bridge the gap between related findings and the practical implementation of MSC therapies, offering insights into the challenges and translational aspects involved in transitioning from preclinical research to clinical applications...
February 23, 2024: Journal of Oral Biosciences
https://read.qxmd.com/read/38402590/manufacturing-parameters-for-the-creation-of-clinical-grade-human-induced-pluripotent-stem-cell-lines-from-umbilical-cord-mesenchymal-stromal-cells
#35
JOURNAL ARTICLE
Liziane Raquel Beckenkamp, Camila Gomes da Silva, Mônica Luiza Immig Von Hohendorff, Karolyn Sassi Ogliari
Induced pluripotent stem cells (iPSCs) are reprogrammed cells with a remarkable capacity for unlimited expansion and differentiation into various cell types. Companies worldwide are actively engaged in developing clinical-grade iPSC lines to address the needs of regenerative medicine, immunotherapies, and precision medicine. However, ensuring the safety and quality of iPSCs is essential, with adherence to Good Manufacturing Practices (GMP) and ethical considerations being paramount. Perinatal cell and tissue banks, such as umbilical cord (UC) blood and tissue banks, are emerging as ideal sources for generating iPSCs due to their unique characteristics and GMP compliance...
February 25, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38398465/perspectives-for-the-use-of-umbilical-cord-blood-in-transplantation-and-beyond-initiatives-for-an-advanced-and-sustainable-public-banking-program-in-greece
#36
JOURNAL ARTICLE
Patra Pateraki, Helen Latsoudis, Anastasia Papadopoulou, Ioanna Gontika, Irene Fragiadaki, Irene Mavroudi, Nikoleta Bizymi, Aristea Batsali, Michail E Klontzas, Angeliki Xagorari, Efstathios Michalopoulos, Damianos Sotiropoulos, Evangelia Yannaki, Catherine Stavropoulos-Giokas, Helen A Papadaki
The umbilical cord blood (UCB) donated in public UCB banks is a source of hematopoietic stem cells (HSC) alternative to bone marrow for allogeneic HSC transplantation (HSCT). However, the high rejection rate of the donated units due to the strict acceptance criteria and the wide application of the haploidentical HSCT have resulted in significant limitation of the use of UCB and difficulties in the economic sustainability of the public UCB banks. There is an ongoing effort within the UCB community to optimize the use of UCB in the field of HSCT and a parallel interest in exploring the use of UCB for applications beyond HSCT i...
February 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38397024/therapeutic-potential-in-wound-healing-of-allogeneic-use-of-equine-umbilical-cord-mesenchymal-stem-cells
#37
JOURNAL ARTICLE
Ailén Iribarne, María Belén Palma, Laura Andrini, Fernando Riccillo, Delfina Rodriguez, Martín Casella, Felipe Garay, Julieta Spoto Zabala, Leandro Mazza, Adriana Muro, Guillermo Buero, Santiago G Miriuka, Edgardo Carosella, Marcela N García
Wound healing after skin injury is a complex process, particularly in equines where leg wounds are prevalent and their repair is complicated due to the anatomical characteristics. Conventional treatments are not effective enough. The umbilical cord offers an unlimited source of adult mesenchymal stem cells (ucMSCs) from Wharton's jelly tissue. The present study aims to demonstrate the safety and therapeutic potential of the allogeneic use of equine ucMSCs (e-ucMSCs) in the healing of severe equine leg wounds...
February 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38396557/comparison-of-umbilical-cord-mesenchymal-stem-cells-and-fibroblasts-as-donor-nuclei-for-handmade-cloning-in-sheep-using-a-single-cell-transcriptome
#38
JOURNAL ARTICLE
Weijian Li, Yalan Liu, Guizhen Zhou, Zhuo Li, Zhen Wang, Li Wang, Xiuling Ma, Xuguang Wang
Oocytes are efficient at reprogramming terminally differentiated cells to a totipotent state. Nuclear transfer techniques can exploit this property to produce cloned animals. However, the overall efficiency is low. The use of umbilical cord mesenchymal stem cells (UC-MSCs) as donor nuclei may increase blastocyst rates, but the exact reasons for this remain unexplored. A single-cell transcriptomic approach was used to map the transcriptome profiles of eight-cell embryos that were in vitro-fertilized and handmade-cloned using umbilical cord mesenchymal stem cells and fibroblasts as nuclear donors...
February 10, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38396297/menstrual-blood-derived-endometrial-stem-cell-transplantation-improves-male-reproductive-dysfunction-in-t1d-mice-by-enhancing-antioxidative-capacity
#39
JOURNAL ARTICLE
Yilin Lu, Ruihong Liu, Xingpeng Kang, Shenghui Zhang, Yuliang Sun, Wenqiang Fan, Hongbin Cheng, Yanli Liu, Juntang Lin
Diabetes is known to negatively affect male reproduction. Recent clinical results have confirmed that mesenchymal stem cell (MSC)-based therapies are safe and effective for the treatment of diabetes. However, the effect and potential mechanism through which MSC transplantation improves diabetes-derived male reproductive dysfunction are still unknown. In the present study, we first established a male T1D mouse model through intraperitoneal injection of streptozotocin for five consecutive days. Subsequently, we evaluated the blood glucose levels, fertility, and histology and immunology of the pancreas, testes, and penis of T1D mice with or without transplantation of menstrual blood-derived endometrial stem cells (MenSCs) or umbilical cord mesenchymal stem cells (UCMSCs)...
February 23, 2024: Reproductive Sciences
https://read.qxmd.com/read/38387795/revolutionizing-endodontics-innovative-approaches-for-treating-mature-teeth-with-closed-apices-and-apical-lesions-a-report-of-two-cases
#40
JOURNAL ARTICLE
Claudia Brizuela, Gastón Meza, Maroun Khoury
Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization...
February 20, 2024: Journal of Endodontics
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