keyword
Keywords Umbilical cord Mesenchymal ste...

Umbilical cord Mesenchymal stem cells

https://read.qxmd.com/read/38492134/understanding-the-angiogenic-characteristics-of-clinical-grade-mesenchymal-stromal-cells-isolated-from-human-umbilical-cord
#1
JOURNAL ARTICLE
Charlotte Carcopino, Elisa Rossi, Miryam Mebarki, Divina El Hamaoui, Pascale Gaussem, Jérôme Larghero, David M Smadja, Audrey Cras
Addressing the challenges in managing ischemic tissue repair and remodelling remains a prominent clinical concern. Current research is heavily concentrated on identifying innovative cell-based therapies with the potential to enhance revascularization in patients affected by these diseases. We have previously developed and validated a manufacturing process for human umbilical cord mesenchymal stromal cells (UC-MSCs)-based cell therapy medicinal product, according to Good Manufacturing Practices. In this study, we demonstrate that these UC-MSCs enhance the proliferation and migration of endothelial cells and the formation of capillary structures...
March 16, 2024: Stem cell reviews and reports
https://read.qxmd.com/read/38491537/exosomes-derived-from-umbilical-cord-mesenchymal-stem-cells-inhibit-the-nf-%C3%AE%C2%BAb-mapk-signaling-pathway-and-reduce-the-inflammatory-response-to-promote-recovery-from-spinal-cord-injury
#2
JOURNAL ARTICLE
Zhiwei Luan, Jingsong Liu, Mi Li, Yangyang Wang, Yansong Wang
Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system and leads to incomplete or complete loss of the body's autonomous motor and sensory functions, seriously endangering human health. Recently, exosomes have been proposed as important substances in cell-to-cell interactions. Mesenchymal stem cell (MSC)-derived exosomes exert good therapeutic effects and play a crucial role in neurological damage repair. However, the detailed mechanisms underlying their effects remain unknown...
March 16, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38490657/human-umbilical-cord-mesenchymal-stem-cell-therapy-for-renal-dysfunction-in-alport-syndrome-protocol-for-an-open-label-single-arm-trial-in-china
#3
JOURNAL ARTICLE
Li Huang, Jun Zou, Yuxin Zhang, Jiaowei Gu, Jianlong Wu, Che Zhang
INTRODUCTION: Alport syndrome (AS) is one of the most common fatal hereditary renal diseases in human, with a high risk of progressing to end-stage renal disease without effective treatments. Mesenchymal stem cells (MSCs) have recently emerged as a promising therapeutic strategy for chronic kidney disease. However, the safety and therapeutic potential of MSC transfusion for patients with AS are still need to be confirmed. Therefore, we have designed a clinical trial to evaluate the hypothesis that intravenous infusion of human umbilical cord-derived MSC (hUC-MSC) is safe, feasible, and well-tolerated in children with AS...
March 15, 2024: BMJ Open
https://read.qxmd.com/read/38484819/recombinant-human-collagen-i-carboxymethyl-chitosan-hydrogel-loaded-with-long-term-released-hucmscs-derived-exosomes-promotes-skin-wound-repair
#4
JOURNAL ARTICLE
Qiong Wu, Yayuan Guo, Hongwei Li, Dan Zhang, Shixu Wang, Jianing Hou, Nanqiong Cheng, Mengfei Huang, Linna Luo, Yuan Li, Yurong Zhao, Hong Tan, Changxin Jin
BACKGROUND: Stem cell exosomes are beneficial in accelerating wound repair. However, the therapeutic function is limited due to its rapid clearance in vivo. To improve the functionality of exosomes in cutaneous wound healing, a novel hydrogel was designed and fabricated by recombinant human collagen I and carboxymethyl chitosan loaded with exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs), named as the rhCol I/CMC-Exos hydrogel. METHODS: Exosomes were extracted from hUCMSCs and were characterizated by TEM (Transmission Electron Microscopy), and biomarker detection...
March 12, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38479670/study-of-chondrogenesis-of-umbilical-cord-mesenchymal-stem-cells-in-curdlan-poly-vinyl-alcohol-composite-hydrogels-and-its-mechanical-properties-of-freezing-thawing-treatments
#5
JOURNAL ARTICLE
Yu-Chieh Su, Yu Chang, Wei-Chang Lee, Jhih-Han Wang, Takumi Narita, Hiroyuki Takeno, Jie-Yu Syu, I-Ming Jou, Wen-Chuan Hsieh
The curdlan gel is a natural material produced by bacteria. It utilizes chemical cross-linking reactions to form a 3D porous composite hydrogel, increasing its porosity and water content, and improving its mechanical properties. It can be used in tissue repair and regenerative medicine. Curdlan-Poly(vinyl alcohol) (PVA) composite hydrogel can rapidly swell within 1 min due to its porous structure. Compression tests confirmed that it still maintains its original mechanical strength, even after five repeated freeze-thaw (FT) processes, making it suitable for long-term cryopreservation...
March 11, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38476629/human-umbilical-cord-mesenchymal-stem-cells-protect-mc3t3-e1-osteoblasts-from-dexamethasone-induced-apoptosis-via-induction-of-the-nrf2-are-signaling-pathway
#6
JOURNAL ARTICLE
Chen Qiu, Zhaowen Li, Puji Peng
OBJECTIVE: To investigate the protective effect human umbilical cord mesenchymal stem cells (hUC-MSCs) have on Dexamethasone (Dex)-induced apoptosis in osteogenesis via the Nrf2-ARE signaling pathway. METHODS: Glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) was developed in rats through the administration of lipopolysaccharide and methylprednisolone. The incidence of femoral head necrosis, cavity notch, apoptosis of osteoblasts, and bone density were observed by HE staining, TUNEL staining, and Micro-CT...
December 2024: Regenerative Therapy
https://read.qxmd.com/read/38472335/proteomic-characterization-of-huc-msc-extracellular-vesicles-and-evaluation-of-its-therapeutic-potential-to-treat-alzheimer-s-disease
#7
JOURNAL ARTICLE
Shuang Li, Jiayi Zhang, Xinxing Liu, Ningmei Wang, Luyao Sun, Jianling Liu, Xingliang Liu, Abolfazl Masoudi, Hui Wang, Chunxia Li, Chunyan Guo, Xifu Liu
In recent years, human umbilical cord mesenchymal stem cell (hUC-MSC) extracellular vesicles (EVs) have been used as a cell replacement therapy and have been shown to effectively overcome some of the disadvantages of cell therapy. However, the specific mechanism of action of EVs is still unclear, and there is no appropriate system for characterizing the differences in the molecular active substances of EVs produced by cells in different physiological states. We used a data-independent acquisition (DIA) quantitative proteomics method to identify and quantify the protein composition of two generations EVs from three different donors and analysed the function and possible mechanism of action of the proteins in EVs of hUC-MSCs via bioinformatics...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38462642/identifying-key-antioxidative-stress-factors-regulating-nrf2-in-the-genioglossus-with-human-umbilical-cord-mesenchymal-stem-cell-therapy
#8
JOURNAL ARTICLE
Haixian Guo, Yue Liu, Xinlu Yu, Na Tian, Yan Liu, Dan Yu
Intermittent hypoxia in patients with obstructive sleep apnea (OSA) hypopnea syndrome (OSAHS) is associated with pharyngeal cavity collapse during sleep. The effect of human umbilical cord mesenchymal stem cells (HUCMSCs) on OSA-induced oxidative damage in the genioglossus and whether nuclear factor erythroid 2-related factor 2 (Nrf2) or its upstream genes play a key role in this process remains unclear. This study aimed to identify the key factors responsible for oxidative damage during OSAHS through Nrf2 analysis and hypothesize the mechanism of HUCMSC therapy...
March 10, 2024: Scientific Reports
https://read.qxmd.com/read/38460812/comparative-analysis-of-effects-of-conditioned-mediums-obtained-from-2d-or-3d-cultured-mesenchymal-stem-cells-on-kidney-functions-of-diabetic-rats-early-intervention-could-potentiate-transdifferentiation-of-parietal-epithelial-cell-into-podocyte-precursors
#9
JOURNAL ARTICLE
Serbay Ozkan, Basak Isildar, Hakan Sahin, Halil Ibrahim Saygi, Dildar Konukoglu, Meral Koyuturk
AIM: The secretome of mesenchymal stem cells (MSCs) could be a potential therapeutic intervention for diabetes and associated complications like nephropathy. This study aims to evaluate the effects of conditioned mediums (CMs) collected from umbilical cord-derived MSCs incubated under 2-dimensional (2D) or 3D culture conditions on kidney functions of rats with type-I diabetes (T1D). MAIN METHODS: Sprague-Dawley rats were treated with 20 mg/kg streptozocin for 5 consecutive days to induce T1D, and 12 doses of CMs were applied intraperitoneally for 4 weeks...
March 7, 2024: Life Sciences
https://read.qxmd.com/read/38460354/therapeutic-effect-of-human-umbilical-cord-mesenchymal-stem-cells-and-their-conditioned-medium-on-lps-induced-endometritis-in-mice
#10
JOURNAL ARTICLE
Jingyi Li, Xiaodi Yin, Ming Du, Caiyi Wang, Feng Zou, Jun Ma, Yuxia Song
AIM: To explore the effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) and their conditioned medium (MSC-CM) in repairing the endometritis mouse model in vivo. METHODS: Lipopolysaccharide (LPS) was used to induce acute inflammation in endometritis mouse model. Mice were treated in six groups: control group (PBS), model group (LPS), LPS+MSC-CM (6 h) group, LPS+MSC-CM (12 h) group, LPS+MSCs (6 h) group and LPS+MSCs (12 h) group...
March 2, 2024: Tissue & Cell
https://read.qxmd.com/read/38459276/exosomes-derived-from-human-umbilical-cord-mesenchymal-stem-cells-decrease-neuroinflammation-and-facilitate-the-restoration-of-nerve-function-in-rats-suffering-from-intracerebral-hemorrhage
#11
JOURNAL ARTICLE
Chengrui Nan, Yan Zhang, Aobo Zhang, Yunpeng Shi, Dongdong Yan, Zhimin Sun, Qianxu Jin, Haoran Huo, Yayu Zhuo, Zongmao Zhao
Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-ex) have become a hopeful substitute for whole-cell therapy due to their minimal immunogenicity and tumorigenicity. The present study aimed to investigate the hypothesis that hUCMSC-ex can alleviate excessive inflammation resulting from intracerebral hemorrhage (ICH) and facilitate the rehabilitation of the nervous system in rats. In vivo, hemorrhagic stroke was induced by injecting collagenase IV into the striatum of rats using stereotactic techniques...
March 8, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38455624/effect-of-umbilical-cord-mesenchymal-stem-cells-on-hypoxia-inducible-factor-1-alpha-hif-1%C3%AE-production-in-arteriovenous-fistula-avf-animal-model-a-preliminary-study
#12
JOURNAL ARTICLE
Yopie A Habibie, Dessy R Emril, Azharuddin Azharuddin, Dedy Syahrizal
Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that plays a crucial role in cellular responses to hypoxia, such as in the development of intimal hyperplasia, a common complication in arteriovenous fistula (AVF) creation. While the application of umbilical cord mesenchymal stem cells (UC-MSCs) has shown promise in various regenerative medicine applications, including tissue repair and angiogenesis, the effect of UC-MSCs on HIF-1α level in the AVF has not been tested. Therefore, the aim of this study was to evaluate the effect of UC-MSCs administration on HIF-1α levels in the AVF animal model...
December 2023: Narra J
https://read.qxmd.com/read/38455107/multiple-pretreatments-can-effectively-improve-the-functionality-of-mesenchymal-stem-cells
#13
EDITORIAL
Xin-Xing Wan, Xi-Min Hu, Kun Xiong
In this editorial, we offer our perspective on the groundbreaking study entitled "Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells", recently published in World Journal of Stem Cells . Despite over three decades of research on the clinical application of mesenchymal stem cells (MSCs), only a few therapeutic products have made it to clinical use, due to multiple preclinical and clinical challenges yet to be addressed. The study proved the hypoxia and inflammatory factor preconditioning led to higher immunosuppressive effects of MSCs without damaging their biological characteristics, which revealed the combination of inflammatory factors and hypoxic preconditioning offers a promising approach to enhance the function of MSCs...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38455100/cellular-preconditioning-and-mesenchymal-stem-cell-ferroptosis
#14
EDITORIAL
Doaa Hussein Zineldeen, Mazhar Mushtaq, Khawaja Husnain Haider
In this editorial, we comment on the article published in the recent issue of the World Journal of Stem Cells . They focus on stem cell preconditioning to prevent ferroptosis by modulating the cystathionine γ-lyase/hydrogen sulfide (H2 S) pathway as a novel approach to treat vascular disorders, particularly pulmonary hypertension. Preconditioned stem cells are gaining popularity in regenerative medicine due to their unique ability to survive by resisting the harsh, unfavorable microenvironment of the injured tissue...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38455096/therapeutic-utility-of-human-umbilical-cord-derived-mesenchymal-stem-cells-based-approaches-in-pulmonary-diseases-recent-advancements-and-prospects
#15
REVIEW
Min Meng, Wei-Wei Zhang, Shuang-Feng Chen, Da-Rui Wang, Chang-Hui Zhou
Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical symptoms and delaying disease progression but have not shown significant therapeutic effects in patients with lung diseases. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) isolated from the human UC have the capacity for self-renewal and multilineage differentiation...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38454492/human-umbilical-cord-placenta-mesenchymal-stem-cell-conditioned-medium-attenuates-intestinal-fibrosis-in-vivo-and-in-vitro
#16
JOURNAL ARTICLE
Yoon Jeong Choi, Woo Ram Kim, Duk Hwan Kim, Jee Hyun Kim, Jun Hwan Yoo
BACKGROUND: A significant unmet need in inflammatory bowel disease is the lack of anti-fibrotic agents targeting intestinal fibrosis. This study aimed to investigate the anti-fibrogenic properties and mechanisms of the conditioned medium (CM) from human umbilical cord/placenta-derived mesenchymal stem cells (UC/PL-MSC-CM) in a murine intestinal fibrosis model and human primary intestinal myofibroblasts (HIMFs). METHODS: UC/PL-MSC-CM was concentrated 15-fold using a 3 kDa cut-off filter...
March 7, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38450623/human-umbilical-cord-derived-mesenchymal-stem-cells-in-the-treatment-of-multiple-sclerosis-patients-phase-i-ii-dose-finding-clinical-study
#17
JOURNAL ARTICLE
Fatima Jamali, Mayis Aldughmi, Serin Atiani, Ali Al-Radaideh, Said Dahbour, Dana Alhattab, Hind Khwaireh, Sally Arafat, Joud Al Jaghbeer, Reem Rahmeh, Kawthar Abu Moshref, Hisham Bawaneh, Mona R Hassuneh, Bayan Hourani, Osameh Ababneh, Alia Alghwiri, Abdalla Awidi
Multiple sclerosis (MS) is a chronic neuro-inflammatory disease resulting in disabilities that negatively impact patients' life quality. While current treatment options do not reverse the course of the disease, treatment using mesenchymal stromal/stem cells (MSC) is promising. There has yet to be a consensus on the type and dose of MSC to be used in MS. This work aims to study the safety and efficacy of two treatment protocols of MSCs derived from the umbilical cord (UC-MSCs) and their secretome. The study included two groups of MS patients; Group A received two intrathecal doses of UC-MSCs, and Group B received a single dose...
2024: Cell Transplantation
https://read.qxmd.com/read/38449506/adipose-tissue-and-umbilical-cord-tissue-potential-sources-of-mesenchymal-stem-cells-for-liver-fibrosis-treatment
#18
JOURNAL ARTICLE
Hafiz Ghufran, Maryam Azam, Azra Mehmood, Muhammad Umair, Maria T Baig, Saba Tasneem, Hira Butt, Sheikh Riazuddin
BACKGROUND/AIMS: Mesenchymal stem cells (MSCs) are potential alternatives for liver fibrosis treatment; however, their optimal sources remain uncertain. This study compares the ex-vivo expansion characteristics of MSCs obtained from adipose tissue (AT) and umbilical cord (UC) and assesses their therapeutic potential for liver fibrosis treatment. METHODS: Since MSCs from early to mid-passage numbers (P2-P6) are preferable for cellular therapy, we investigated the growth kinetics of AT-MSCs and UC-MSCs up to P6 and evaluated their therapeutic effects in a rat model of liver fibrosis induced by diethylnitrosamine...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38444129/-effects-of-human-umbilical-cord-mesenchymal-stem-cells-mscs-derived-exosomes-on-pulmonary-vascular-remodeling-in-hypoxic-pulmonary-hypertension
#19
JOURNAL ARTICLE
Hong Liu, Yu-Wei Zhang, Qing-Qing Zhang, Yu-Xiang Wang, Ri-Li Ge, Lan Ma
The present study aimed to investigate the effect of human umbilical cord mesenchymal stem cells (MSCs)-derived exosomes (MSCs-Exo) on mice with hypoxic pulmonary hypertension (HPH). MSCs were isolated and cultured from human umbilical cords under aseptic conditions, and exosomes were extracted from the supernatants and identified. Healthy SPF C57BL/6 mice were randomly divided into three groups: normoxic group, hypoxic group, and hypoxic+MSCs-Exo group. Mice in the hypoxic group and the hypoxic+MSCs-Exo group were maintained for 28 d at an equivalent altitude of 5 000 m in a hypobaric chamber to establish HPH mouse model...
February 25, 2024: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://read.qxmd.com/read/38443990/mesenchymal-stem-stromal-cells-from-human-pluripotent-stem-cell-derived-brain-organoid-enhance-the-ex-vivo-expansion-and-maintenance-of-hematopoietic-stem-progenitor-cells
#20
JOURNAL ARTICLE
Ya Zhou, Xinping Cai, Xiuxiu Zhang, Yong Dong, Xu Pan, Mowen Lai, Yimeng Zhang, Yijin Chen, Xiaohong Li, Xia Li, Jiaxin Liu, Yonggang Zhang, Feng Ma
BACKGROUND: Mesenchymal stem/stromal cells (MSCs) are of great therapeutic value due to their role in maintaining the function of hematopoietic stem/progenitor cells (HSPCs). MSCs derived from human pluripotent stem cells represent an ideal alternative because of their unlimited supply. However, the role of MSCs with neural crest origin derived from HPSCs on the maintenance of HSPCs has not been reported. METHODS: Flow cytometric analysis, RNA sequencing and differentiation ability were applied to detect the characteristics of stromal cells from 3D human brain organoids...
March 5, 2024: Stem Cell Research & Therapy
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