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Umbilical cord Mesenchymal stem cells

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https://www.readbyqxmd.com/read/29908640/comparative-study-of-regenerative-effects-of-mesenchymal-stem-cells-derived-from-placental-amnion-chorion-and-umbilical-cord-on-dermal-wounds
#1
Juliane Ertl, Melanie Pichlsberger, Alexandru-Cristian Tuca, Paul Wurzer, Jakob Fuchs, Stefan H Geyer, Barbara Maurer-Gesek, Wolfgang J Weninger, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars-Peter Kamolz, Ingrid Lang
OBJECTIVE: Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorionic plate and Wharton's jelly-derived MSCs (WJ-MSCs) from the umbilical cord. METHODS: We topically applied PMSCs onto skin wounds in mice using the dermal substitute Matriderm® as carrier and evaluated wound healing parameters...
May 2018: Placenta
https://www.readbyqxmd.com/read/29905411/anti-inflammatory-and-antioxidant-effects-of-mesenchymal-and-hematopoietic-stem-cells-in-a-rheumatoid-arthritis-rat-model
#2
Hanan Abdelmawgoud, Asmaa Saleh
BACKGROUND: Mesenchymal stem cells (MSCs) are of increased importance because of their capacity to counteract inflammation and suppress host immune responses. OBJECTIVES: The aim of the study was to compare the effectiveness of MSCs and hematopoietic stem cells (HSCs) in the treatment of rheumatoid arthritis (RA). MATERIAL AND METHODS: Paw swelling was assessed by measuring the thickness of the hind paws using a caliper. Cytokines - interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 - and rheumatoid factor (RF) were measured using enzyme-linked immunosorbent assay (ELISA) kits...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905067/surface-functionalization-of-polymeric-nanoparticles-with-umbilical-cord-derived-mesenchymal-stem-cell-membrane-for-tumor-targeted-therapy
#3
Na Yang, Yanping Ding, Yinlong Zhang, Bin Wang, Xiao Zhao, Keman Cheng, Yixin Huang, Mohammad Taleb, Jing Zhao, Wen-Fei Dong, Lirong Zhang, Guangjun Nie
Multiple cell plasma membranes have been utilized for surface functionalization of synthetic nanomaterials and construction of biomimetic drug delivery systems for cancer treatment. The natural characters and facile isolation of original cells facilitate the biomedical applications of plasma membranes in functionalizing nanocarriers. Human umbilical cord-derived mesenchymal stem cells (MSC) have been identified to show tropism towards malignant lesions and have great advantages in ease of acquisition, low immunogenicity, and high proliferative ability...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29895317/hypoxia-with-wharton-s-jelly-mesenchymal-stem-cell-coculture-maintains-stemness-of-umbilical-cord-blood-derived-cd34-cells
#4
Dewan Zhao, Lingjia Liu, Qiang Chen, Fangfang Wang, Qiuyang Li, Qiang Zeng, Jingcao Huang, Maowen Luo, Wenxian Li, Yuhuan Zheng, Ting Liu
BACKGROUND: The physiological approach suggests that an environment associating mesenchymal stromal cells with low O2 concentration would be most favorable for the maintenance of hematopoietic stem/progenitor cells (HSPCs). To test this hypothesis, we performed a coculture of cord blood CD34+ cells with Wharton's jelly mesenchymal stem cells (WJ-MSCs) under different O2 concentration to simulate the growth of HSPCs in vivo, and assessed the impacts on stemness maintenance and proliferation of cord blood HSPCs in vitro...
June 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29892282/mis416-enhances-therapeutic-functions-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-against-experimental-colitis-by-modulating-systemic-immune-milieu
#5
Byung-Chul Lee, Nari Shin, Jin Young Lee, Insung Kang, Jae-Jun Kim, Seung Eun Lee, Soon Won Choi, Gill A Webster, Kyung-Sun Kang
Human adult stem cells, including umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs), have recently been considered a promising alternative treatment for inflammatory bowel disease (IBD) due to their unique immunomodulatory properties and ability to promote tissue regeneration. However, despite many years of research and pre-clinical studies, results from clinical trials using these cells have been diverse and conflicting. This discrepancy is caused by several factors, such as poor engraftment, low survival rate, and donor-dependent variation of the cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29875586/human-umbilical-cord-derived-mesenchymal-stem-cells-reduce-monosodium-iodoacetate-induced-apoptosis-in-cartilage
#6
Yu-Hsun Chang, Kun-Chi Wu, Hwan-Wun Liu, Tang-Yuan Chu, Dah-Ching Ding
Objective: The present study investigated the therapeutic potential and underlying mechanisms of human umbilical cord mesenchymal stem cells (HUCMSCs) on joint cartilage destruction induced by monosodium iodoacetate (MIA) in mice. Materials and Methods: HUCMSCs were tested for mesenchymal stem cell (MSC) characteristics including surface markers by flow cytometry and mesoderm differentiation (adipogenesis, osteogenesis, and chondrogenesis). Terminal deoxynucleotidyl transferase dUTP nick end labeling assay and Western blot assay were used to evaluate MIA-induced chondrocyte apoptosis...
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29871514/significant-improvement-of-acute-complete-spinal-cord-injury-patients-diagnosed-by-a-combined-criteria-implanted-with-neuroregen-scaffolds-and-mesenchymal-stem-cells
#7
Zhifeng Xiao, Fengwu Tang, Yannan Zhao, Guang Han, Na Yin, Xing Li, Bing Chen, Sufang Han, Xianfeng Jiang, Chen Yun, Changyu Zhao, Shixiang Cheng, Sai Zhang, Jianwu Dai
Stem cells and biomaterials transplantation hold a promising treatment for functional recovery in spinal cord injury (SCI) animal models. However, the functional recovery of complete SCI patients was still a huge challenge in clinic. Additionally, there is no clinical standard procedure available to diagnose precisely an acute patient as complete SCI. Here, two acute SCI patients, with injury at thoracic 11 (T11) and cervical 4 (C4) level respectively, were judged as complete injury by a stricter method combined with American Spinal Injury Association (ASIA) Impairment Scale, magnetic resonance imaging (MRI) and nerve electrophysiology...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29867527/the-reparative-abilities-of-menstrual-stem-cells-modulate-the-wound-matrix-signals-and-improve-cutaneous-regeneration
#8
Jimena Cuenca, Alice Le-Gatt, Valentina Castillo, Jose Belletti, Macarena Díaz, Mónica Kurte G, Paz L Gonzalez, Francisca Alcayaga-Miranda, Christina M A P Schuh, Fernando Ezquer, Marcelo Ezquer, Maroun Khoury
Considerable advances have been made toward understanding the cellular and molecular mechanism of wound healing, however, treatments for chronic wounds remain elusive. Emerging concepts utilizing mesenchymal stem cells (MSCs) from umbilical cord, adipose tissue and bone marrow have shown therapeutical advantages for wound healing. Based on this positive outcome, efforts to determine the optimal sources for MSCs are required in order to improve their migratory, angiogenic, immunomodulatory, and reparative abilities...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29861743/treatment-of-full-thickness-rotator-cuff-tendon-tear-using-umbilical-cord-blood-derived-mesenchymal-stem-cells-and-polydeoxyribonucleotides-in-a-rabbit-model
#9
Dong Rak Kwon, Gi-Young Park, Sang Chul Lee
Objective: The aim of this study was to investigate regenerative effects of ultrasound- (US-) guided injection with human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) and/or polydeoxyribonucleotide (PDRN) injection in a chronic traumatic full-thickness rotator cuff tendon tear (FTRCTT) in a rabbit model. Methods: Rabbits ( n = 32) were allocated into 4 groups. After a 5 mm sized FTRCTT just proximal to the insertion site on the subscapularis tendon was created by excision, the wound was immediately covered by a silicone tube to prevent natural healing...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29861739/evaluation-of-the-curative-effect-of-umbilical-cord-mesenchymal-stem-cell-therapy-for-knee-arthritis-in-dogs-using-imaging-technology
#10
Bei-Ying Zhang, Bing-Yun Wang, Shao-Chuan Li, Dong-Zhang Luo, Xiaoshu Zhan, Sheng-Feng Chen, Zhi-Sheng Chen, Can-Ying Liu, Hui-Qin Ji, Yin-Shan Bai, Dong-Sheng Li, Yang He
Objective: The aim of this study was to assess the efficacy of canine umbilical cord mesenchymal stem cells (UC-MSCs) on the treatment of knee osteoarthritis in dogs. Methods: Eight dogs were evenly assigned to two groups. The canine model of knee osteoarthritis was established by surgical manipulation of knee articular cartilage on these eight dogs. UC-MSCs were isolated from umbilical cord Wharton's jelly by 0.1% type collagenase I and identified by immunofluorescence staining and adipogenic and osteogenic differentiation in vitro ...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29848167/exosomes-derived-from-bone-mesenchymal-stem-cells-repair-traumatic-spinal-cord-injury-via-suppressing-the-activation-of-a1-neurotoxic-reactive-astrocytes
#11
Wei Liu, Yongxiang Wang, Fangyi Gong, Yuluo Rong, Yongjun Luo, Pengyu Tang, Zheng Zhou, Zhimin Zhou, Tao Xu, Tao Jiang, Siting Yang, Guoyong Yin, Jian Chen, Jin Fan, Weihua Cai
Mesenchymal stem cell (MSC) transplantation is now considered as an effective treatment strategy for traumatic spinal cord injury (SCI). However, several key issues remain unresolved, including low survival rates, cell dedifferentiation, and tumor formation. Recent studies have demonstrated that the therapeutic effect of transplanted stem cells is primarily paracrine-mediated. Exosomes are an important paracrine factor that can be used as a direct therapeutic agent. However, there are few reports on the application of exosomes derived from bone MSCs (BMSCs-Exos) in treating SCI...
May 31, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29845511/umbilical-cord-mesenchymal-stem-cells-conditioned-medium-promotes-a%C3%AE-25-35-phagocytosis-by-modulating-autophagy-and-a%C3%AE-degrading-enzymes-in-bv2-cells
#12
Zhihao Xu, Wenbin Nan, Xiaoyue Zhang, Yuliang Sun, Jichao Yang, Kecheng Lu, Yalin Liu, Yaoxin Gao, Fen Yang, Wenchao Mao, Xuekun Xing, Jiang Du, Han Li, Yonghai Li, Huigen Feng, Zhiqing Yuan, Juntang Lin
Mesenchymal stem cell (MSC) therapy is a promising prospect for the treatment of Alzheimer's disease (AD); however, the underlying mechanisms by which MSCs mediate positive effects are still unclear. We speculated that MSCs mediate microglial autophagy and enhance the clearance of Aβ. To test this hypothesis, we cultured BV2 microglial cells with umbilical cord mesenchymal stem cells conditioned medium (ucMSCs-CM) in the presence or absence of Aβ25-35 oligomers. We investigated BV2 cell proliferation, cell death, and Aβ25-35 phagocytosis as well as protein expression levels of LC3, Beclin-1, p62, insulin-degrading enzyme (IDE), and neprilysin (Nep) with western blotting...
May 29, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29843192/cd73-cd90-cd105-and-cadherin-11-rt-pcr-screening-for-mesenchymal-stem-cells-from-cryopreserved-human-cord-tissue
#13
Hung Pham, Richard Tonai, Miya Wu, Chiara Birtolo, Monica Chen
Background and Objectives: Mesenchymal stem cells (MSCs) are self-renewing, non-specialized cells used clinically in tissue regeneration and sourced from bone marrow, peripheral blood, umbilical cord blood and umbilical cord tissue (UCT). To demonstrate an alternative method for MSC detection, cryopreserved UCT and expanded MSC were screened for MSC markers CD73, CD90, CD105 and CDH-11 by RT-PCR. Methods and Results: Human UCT were washed, sectioned, cryopreserved with 10% DMSO and stored in the vapor phase of liquid nitrogen...
May 30, 2018: International Journal of Stem Cells
https://www.readbyqxmd.com/read/29805590/suppression-of-tumor-cell-proliferation-and-migration-by-human-umbilical-cord-mesenchymal-stem-cells-a-possible-role-for-apoptosis-and-wnt-signaling
#14
Yin Yuan, Chang Zhou, Xuan Chen, Changli Tao, Huiqing Cheng, Xin Lu
Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential therapeutic tools for solid tumors. However, there are numerous inconsistent results regarding the effects of hUCMSCs on tumors, and the mechanisms underlying this remain poorly understood. The present study further examined this controversial issue by analyzing the molecular mechanisms of the inhibitory effects of hUCMSCs on the proliferation and migration of the human lung cancer A549 cell line and the human hepatocellular carcinoma (HCC) BEL7402 cell line in vitro ...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29804170/validation-of-reference-and-identity-defining-genes-in-human-mesenchymal-stem-cells-cultured-under-unrelated-fetal-bovine-serum-batches-for-basic-science-and-clinical-application
#15
Federica Banfi, Alessandra Colombini, Carlotta Perucca Orfei, Valentina Parazzi, Enrico Ragni
The molecular profile of human mesenchymal stem cells (MSCs) have emerged as a key factor in defining their identity. Nevertheless, the effect of fetal bovine serum (FBS) batches or origin on MSC molecular signature has been neglected. In this frame, chemical fingerprint of FBS batches from unrelated countries showed strong correlation between chemical composition and country of origin. Thus, the aim of this study was to evaluate in stem cells isolated from bone marrow (BMMSCs) and umbilical cord-blood (CBMSCs) the effects of independently collected FBS batches on both twelve commonly used reference genes (RGs) and a selected panel of thirty-eight genes crucial for MSC definition in both research and clinical settings...
May 26, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29789652/small-hypoxia-primed-mesenchymal-stem-cells-attenuate-graft-versus-host-disease
#16
YongHwan Kim, Hye Jin Jin, Jinbeom Heo, Hyein Ju, Hye-Yeon Lee, Sujin Kim, Seungun Lee, Jisun Lim, Sang Young Jeong, JiHye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hyun Ho Hwang, Hwan Yeul Yu, Chae-Min Ryu, Hong Bae Jeon, Dong-Myung Shin
Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases due to their immunosuppressive capacity. Here, we show that Small MSCs primed with Hypoxia and Calcium ions (SHC-MSCs) exhibit enhanced stemness and immunomodulatory functions for treating allogeneic conflicts. Compared with naïve cultured human umbilical cord blood-derived MSCs, SHC-MSCs were resistant to passage-dependent senescence mediated via the monocyte chemoattractant protein-1 and p53/p21 cascade and secreted large amounts of pro-angiogenic and immunomodulatory factors, resulting in suppression of T-cell proliferation...
May 22, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29789615/il-37-isoform-d-downregulates-pro-inflammatory-cytokines-expression-in-a-smad3-dependent-manner
#17
Mingsheng Zhao, Yulan Li, Chun Guo, Liyang Wang, Hongxia Chu, Faliang Zhu, Yan Li, Xiaoyan Wang, Qun Wang, Wei Zhao, Yongyu Shi, WanJun Chen, Lining Zhang
IL-37 is a new member of IL-1 family and possesses five different isoforms (named as IL-37 a-e). IL-37b has been demonstrated as a physiological suppressor of immune responses. However, the function of other isoforms remains unknown. Here, we show that IL-37d possesses anti-inflammatory roles both in vitro and in vivo. Firstly, IL-37d is expressed in peripheral blood mononuclear cells (PBMCs) and umbilical cords-derived mesenchymal stem cells (UCMSCs). Secondly, IL-37d overexpression markedly inhibits IL-1β-induced IL-6 production in A549 cells...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29778021/the-homing-of-human-umbilical-cord-derived-mesenchymal-stem-cells-and-the-subsequent-modulation-of-macrophage-polarization-in-type-2-diabetic-mice
#18
Yaqi Yin, Haojie Hao, Yu Cheng, Jieqing Gao, Jiejie Liu, Zongyan Xie, Qi Zhang, Li Zang, Weidong Han, Yiming Mu
Umbilical cord-derived mesenchymal stem cells (UC-MSCs), with both immunomodulatory and pro-regenerative properties, are promising for the treatment of type 2 diabetes mellitus (T2DM). As efficient cell therapy largely relies on appropriate homing to target tissues, knowing where and to what extent injected UC-MSCs have homed is critically important. However, bio-distribution data for UC-MSCs in T2DM subjects are extremely limited. Beneficial effects of UC-MSCs on T2DM subjects are associated with increased M2 macrophages, but no systemic evaluation of M2 macrophages has been performed in T2DM individuals...
May 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29776835/the-combination-of-mannitol-and-temozolomide-increases-the-effectiveness-of-stem-cell-treatment-in-a-chronic-stroke-model
#19
Chunggab Choi, Hye Min Kim, Jeeheun Shon, Jiae Park, Hyeong-Taek Kim, Suk Ho Kang, Seung-Hun Oh, Nam Keun Kim, Ok Joon Kim
BACKGROUND: The blood-brain barrier (BBB) presents a significant challenge to the therapeutic efficacy of stem cells in chronic stroke. Various methods have been developed to increase BBB permeability, but these are associated with adverse effects and are, therefore, not clinically applicable. We recently identified that combination drug treatment of mannitol and temozolomide improved BBB permeability in vitro. Here, we investigated whether this combination could increase the effectiveness of stem cell treatment in an animal model of chronic ischemic stroke...
May 15, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29767256/umbilical-cord%C3%A2-derived-mesenchymal-stem-cells-can-inhibit-the-biological-functions-of-melanoma-a375-cells
#20
Wei Wang, Li Li, Fei Chen, Yu Yang
Tumor tropism is an important property of mesenchymal stem cells (MSCs) that has been used in tumor‑targeting therapies. However, the effects of MSCs on tumors remain controversial. The aim of the present study was to investigate the effects of MSCs on A375 melanoma cells. Umbilical cord‑derived mesenchymal stem cells (UCMSCs) were co‑cultured with A375 cells. MTT and Transwell assays were used to assess cell proliferation and invasion, while flow cytometry was performed to detect the apoptosis and the cell cycle distribution of A375 cells...
May 16, 2018: Oncology Reports
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