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https://www.readbyqxmd.com/read/28421664/intermediate-and-long-term-outcome-of-piggyback-drainage-connecting-glaucoma-drainage-device-to-a-device-in-situ-for-improved-intraocular-pressure-control
#1
Edward Dervan, Edward Lee, Antonio Giubilato, Tina Khanam, Panayiotis Maghsoudlou, William H Morgan
IMPORTANCE: This study provides results of a treatment option for patients with failed primary glaucoma drainage device BACKGROUND: To describe and evaluate the long term intraocular pressure (IOP) control and complications of a new technique joining a second glaucoma drainage device (GDD) directly to an existing GDD: termed "piggyback drainage". DESIGN: A retrospective, interventional cohort study PARTICIPANTS: 18 eyes of 17 patients who underwent piggyback drainage between 2004 and 2013 inclusive...
April 19, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28418499/sphingosine-1-phosphate-s1p-related-response-of-human-conjunctival-fibroblasts-after-filtration-surgery-for-glaucoma
#2
Yuka Aoyama-Araki, Megumi Honjo, Takatoshi Uchida, Reiko Yamagishi, Kuniyuki Kano, Junken Aoki, Makoto Aihara
Purpose: To investigate levels of sphingosine-1-phosphate (S1P) in aqueous fluid samples taken before and after filtration surgery and S1P-induced human conjunctival fibroblast (HCF) responses. Methods: Levels of S1P and its related sphingophospholipids in aqueous fluid obtained immediately before and after filtration surgery were determined by liquid chromatography-tandem mass spectrometry. HCFs were used for all in vitro experiments. The expression of five S1P receptor subtypes in HCFs was examined by quantitative real-time PCR...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28408469/cell-wall-deficient-l-form-bacteria-in-the-21st-century-a-personal-perspective
#3
REVIEW
Jeff Errington
The peptidoglycan (PG) cell wall is a defining feature of the bacteria. It emerged very early in evolution and must have contributed significantly to the success of these organisms. The wall features prominently in our thinking about bacterial cell function, and its synthesis involves the action of several dozen proteins that are normally essential for viability. Surprisingly, it turns out to be relatively simple to generate bacterial genetic variants called L-forms that completely lack PG. They grow robustly provided that lack of the cell wall is compensated for by an osmoprotective growth medium...
April 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28400372/risk-factors-for-bleb-related-infection-following-trabeculectomy-surgery-ocular-surface-findings-a-case-control-study
#4
Poornima A Rai, Keith Barton, Ian E Murdoch
PURPOSE: Bleb-related infection (BRI) is a devastating complication of trabeculectomy surgery. The aim of this study was to identify ocular risk factors for BRI with specific emphasis on ocular surface parameters. It has been suggested that the frequency has increased since the introduction of antimetabolites, particularly mitomycin C. DESIGN: A case-control study. METHOD: A clinical study of BRI following trabeculectomy surgery to investigate risk factors by documenting historical data review from patients records, self-reported questionnaire specific to ocular surface symptoms and a repeat detailed clinical examination of the lid, ocular surface and tear film...
October 18, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28389703/use-of-subconjunctival-injections-of-5-fluorouracil-to-rescue-and-prolong-intraocular-pressure-reduction-for-a-failing-ahmed-glaucoma-implant
#5
Kevin Kaplowitz, Sarah Khodadadeh, Samantha Wang, Daniel Lee, James C Tsai
PURPOSE: 5-Fluorouracil (5-FU) has been well described for a failing trabeculectomy bleb, but not for aqueous shunts. We sought to determine whether subconjunctival 5-FU prolongs the intraocular pressure (IOP) efficacy of Ahmed shunts. METHODS: We included all patients with Ahmed FP-7 implantation by one surgeon at Yale University. Patients with <3 months follow-up were excluded. Injections were done on a case-by-case basis, usually for IOP > 21 on >2 medications...
April 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28382282/ursodeoxycholic-acid-induces-death-receptor-mediated-apoptosis-in-prostate-cancer-cells
#6
Won Sup Lee, Ji Hyun Jung, Radha Panchanathan, Jeong Won Yun, Dong Hoon Kim, Hye Jung Kim, Gon Sup Kim, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi, Jin-Myung Jung
BACKGROUND: Bile acids have anti-cancer properties in a certain types of cancers. We determined anticancer activity and its underlying molecular mechanism of ursodeoxycholic acid (UDCA) in human DU145 prostate cancer cells. METHODS: Cell viability was measured with an MTT assay. UDCA-induced apoptosis was determined with flow cytometric analysis. The expression levels of apoptosis-related signaling proteins were examined with Western blotting. RESULTS: UDCA treatment significantly inhibited cell growth of DU145 in a dose-dependent manner...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28380098/algorithm-approach-for-revision-surgery-following-late-onset-bleb-complications-after-trabeculectomy-long-term-follow-up
#7
Claudio I Perez, María J Oportus, Felipe Mellado, Felipe Valenzuela, Cristián Cartes, Daniela López-Ponce, Daniela Salinas-Toro, Remigio López-Solís, Leonidas Traipe
Purpose: The aim of this study was to introduce a reproducible algorithm for the surgical management of late-onset (>2 months) bleb complications after trabeculectomy with mitomycin C. Methods: We performed a retrospective review of eyes treated using a reproducible algorithm approach by a single surgeon for the surgical management of late-onset bleb complications from July 2006 to April 2014. Exclusion criteria were bleb revision with less than 3 months of follow-up or bleb revision combined with other glaucoma procedures at the time of surgery...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28379649/grafts-in-glaucoma-surgery-a-review-of-the-literature
#8
Sahil Thakur, Parul Ichhpujani, Suresh Kumar
Patients with bleb leakage, dehiscence, or infection after trabeculectomy need urgent bleb salvaging to prevent vision loss. Patients who have undergone a glaucoma drainage device surgery may have tube erosion, which is yet another devastating and outcome-compromising complication. The bleb or the tube in such cases needs to be patched by a biologic tissue, which is roofed by the conjunctiva and acts as a barrier against external infections. Sclera, pericardium, cornea, and dura mater are the commonly used patch graft materials...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28377926/platinum-based-drugs-differentially-affect-the-ultrastructure-of-breast-cancer-cell-types
#9
Shadia Al-Bahlani, Buthaina Al-Dhahli, Kawther Al-Adawi, Abdurahman Al-Nabhani, Mohamed Al-Kindi
Breast cancer (BC) is the most common cause of cancer-related death worldwide. Although platinum-based drugs (PBDs) are effective anticancer agents, responsive patients eventually become resistant. While resistance of some cancers to PBDs has been explored, the cellular responses of BC cells are not studied yet. Therefore, we aim to assess the differential effects of PBDs on BC ultrastructure. Three representative cells were treated with different concentrations and timing of Cisplatin, Carboplatin, and Oxaliplatin...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28371125/comparison-of-bleb-morphology-between-trabeculectomy-and-deep-sclerectomy-using-a-clinical-grading-scale-and-anterior-segment-optical-coherence-tomography
#10
Lawrence J Oh, Eugene Wong, Julie Lam, Colin I Clement
IMPORTANCE: This study highlights the role of the filtration bleb for IOP management following Trabeculectomy (TRAB) and deep sclerectomy (DS) in Glaucoma. BACKGROUND: This study serves to analyse the bleb morphology and IOP using the Indiana bleb appearance grading scale (IBAGS) and the anterior-segment optical coherence tomography (AS-OCT) postoperatively and at 3 months. DESIGN: Retrospective study by a single surgeon. PARTICIPANTS: 28 patients with open-angle glaucoma were recruited into the study, 14 in each of the TRAB (fornix) and DS groups...
March 30, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28369000/initial-trabeculectomy-with-mitomycin-c-for-secondary-glaucoma-associated-with-uveitis-in-beh%C3%A3-et-disease-patients
#11
Keiko Komae, Mitsuko Takamoto, Rie Tanaka, Makoto Aihara, Kazuyoshi Ohtomo, Kimiko Okinaga, Junko Matsuda, Hisae Nakahara, Yujiro Fujino, Toshikatsu Kaburaki
PURPOSE: To examine clinical outcomes following an initial trabeculectomy with mitomycin-C for secondary glaucoma associated with uveitis in Behçet disease (BD) patients. DESIGN: Retrospective interventional case series. PATIENTS AND METHODS: Twenty-two eyes in 18 patients with uveitic glaucoma (UG) associated with Behçet disease who underwent an initial trabeculectomy with mitomycin-C between January 1996 and August 2014 were retrospectively reviewed...
March 31, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28368960/ubiquitinated-proteins-isolated-from-tumor-cells-are-efficient-substrates-for-antigen-cross-presentation
#12
Guangjie Yu, Tarsem Moudgil, Zhihua Cui, Yongbin Mou, Lixin Wang, Bernard A Fox, Hong-Ming Hu
We have previously shown that inhibition of the proteasome causes defective ribosomal products to be shunted into autophagosomes and subsequently released from tumor cells as defective ribosomal products in Blebs (DRibbles). These DRibbles serve as an excellent source of antigens for cross-priming of tumor-specific T cells. Here, we examine the role of ubiquitinated proteins (Ub-proteins) in this pathway. Using purified Ub-proteins from tumor cells that express endogenous tumor-associated antigen or exogenous viral antigen, we tested the ability of these proteins to stimulate antigen-specific T-cell responses, by activation of monocyte-derived dendritic cells generated from human peripheral blood mononuclear cells...
March 31, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28365272/erk1-2-signaling-is-required-for-the-initiation-but-not-progression-of-tgf%C3%AE-induced-lens-epithelial-to-mesenchymal-transition-emt
#13
Magdalena C Wojciechowski, Leila Mahmutovic, Daisy Y Shu, Frank J Lovicu
Transforming Growth Factor Beta (TGFβ) potently induces lens epithelial to mesenchymal transition (EMT). The resultant mesenchymal cells resemble those found in plaques of human forms of subcapsular cataract. Smad signaling has long been implicated as the sole driving force of TGFβ-mediated activity. Rat lens epithelial explants were used to examine the role of the Smad-independent signaling, namely the MAPK/ERK1/2 signaling pathway, in the initiation and progression of TGFβ-induced EMT. Phase contrast microscopy was used to observe the morphological changes associated with TGFβ-induced EMT in this model, including cell elongation, cell membrane blebbing, cell loss as indicated by the area of bare capsule and capsular wrinkling...
March 30, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28359219/modification-of-sample-processing-for-the-limulus-amebocyte-lysate-assay-enhances-detection-of-inflammogenic-endotoxin-in-intact-bacteria-and-organic-dust
#14
Kimberly A Hoppe Parr, Suzana Hađina, Brita Kilburg-Basnyat, Yifang Wang, Dulce Chavez, Peter S Thorne, Jerrold P Weiss
The pro-inflammatory potency and causal relationship with asthma of inhaled endotoxins have underscored the importance of accurately assessing the endotoxin content of organic dusts. The Limulus amebocyte lysate (LAL) assay has emerged as the preferred assay, but its ability to measure endotoxin in intact bacteria and organic dusts with similar sensitivity as purified endotoxin is unknown. We used metabolically radiolabeled Neisseria meningitidis and both rough and smooth Escherichia coli to compare dose-dependent activation in the LAL with purified endotoxin from these bacteria and shed outer membrane (OM) blebs...
April 2017: Innate Immunity
https://www.readbyqxmd.com/read/28358901/custom-rt-qpcr-array-for-glaucoma-filtering-surgery-prognosis
#15
Iñaki Rodriguez-Agirretxe, Iker Garcia, Javier Soria, Tatiana Maria Suarez, Arantxa Acera
Excessive subconjunctival scarring is the main reason of failure of glaucoma filtration surgery. We analyzed conjunctival and systemic gene expression patterns after non penetrating deep sclerectomy (NPDS). To find expression patterns related to surgical failure and their correlation with the clinical outcomes. This study consisted of two consecutive stages. The first was a prospective analysis of wound-healing gene expression profile of six patients after NPDS. Conjunctival samples and peripheral blood samples were collected before and 15, 90,180, and 360 days after surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28355172/eyepass-glaucoma-implant-in-open-angle-glaucoma-after-failed-conventional-medical-therapy-clinical-results-of-a-5-year-follow-up
#16
Barbara Wittmann, Cord Huchzermeyer, Robert Rejdak, Udo Reulbach, Thomas Dietlein, Bettina Hohberger, Anselm Jünemann
PURPOSE OF THE STUDY: The purpose of the study was to evaluate the long-term safety and intraocular pressure (IOP) lowering effect of the Eyepass glaucoma implant (GMP Vision Solutions, Inc.). PATIENTS AND METHODS: The prospective study included 15 patients (16 eyes) with primary open-angle glaucoma who underwent an implantation of the Y-shaped Eyepass glaucoma implant. This shunt diverts aqueous from the anterior chamber directly into Schlemm's canal to increase outflow and to lower the IOP...
April 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28352215/myosin-iia-related-actomyosin-contractility-mediates-oxidative-stress-induced-neuronal-apoptosis
#17
Yan Wang, Yingqiong Xu, Qian Liu, Yuanyuan Zhang, Zhen Gao, Mingzhu Yin, Nan Jiang, Guosheng Cao, Boyang Yu, Zhengyu Cao, Junping Kou
Oxidative stress-induced neuronal apoptosis plays an important role in the progression of central nervous system (CNS) diseases. In our study, when neuronal cells were exposed to hydrogen peroxide (H2O2), an exogenous oxidant, cell apoptosis was observed with typical morphological changes including membrane blebbing, neurite retraction and cell contraction. The actomyosin system is considered to be responsible for the morphological changes, but how exactly it regulates oxidative stress-induced neuronal apoptosis and the distinctive functions of different myosin II isoforms remain unclear...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28345564/innovations-in-glaucoma-surgery-from-dr-rajendra-prasad-centre-for-ophthalmic-sciences
#18
Tanuj Dada, Neha Midha, Pooja Shah, Talvir Sidhu, Dewang Angmo, Ramanjit Sihota
Trabeculectomy surgery is the current standard of care in glaucoma for achieving a low target intraocular pressure if medical therapy is not adequate. Augmentation of trabeculectomy with antimetabolites brought a revolutionary change in the long-term success rates of trabeculectomy, but along with it came a plethora of complications. There still is a big window for therapeutic innovations on this subject. The foremost target for these innovations is to modulate the wound healing response after glaucoma drainage surgery...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28337343/long-term-outcomes-of-primary-trabeculectomy-in-diabetic-patients-without-retinopathy-with-primary-angle-closure-glaucoma
#19
Jian Liu, Miaomiao Zhang, Bin Li, Jianrong Wang
Purpose. To evaluate primary trabeculectomy with adjunctive mitomycin-C (MMC) in diabetic patients without retinopathy with primary angle-closure glaucoma (PACG). Design. This is a retrospective case series comparison. Participants. This retrospective trial compared outcomes of 88 eyes that underwent trabeculectomy in patients with diabetes mellitus (DM) without retinopathy and in 97 patients without DM. Methods. In this study, the intraocular pressure (IOP), visual acuity, visual field, and postoperative complications were compared between the two groups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28333953/involvement-of-%C3%AE-and-%C3%AE-actin-isoforms-in-actin-cytoskeleton-organization-and-migration-abilities-of-bleb-forming-human-colon-cancer-cells
#20
Aleksandra Simiczyjew, Antonina Joanna Mazur, Ewelina Dratkiewicz, Dorota Nowak
Amoeboid movement is characteristic for rounded cells, which do not form strong adhesion contacts with the ECM and use blebs as migratory protrusions. It is well known that actin is the main component of mature forms of these structures, but the exact role fulfilled by non-muscle actin isoforms β- and γ- in bleb formation and migration of these cells is still not fully understood. The aim of this study was to establish the role of β- and γ-actin in migration of bleb-forming cancer cells using isoform-specific antibodies and expression of fluorescently tagged actin isoforms...
2017: PloS One
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