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https://www.readbyqxmd.com/read/28640115/management-of-neovascular-glaucoma-with-intravitreal-ranibizumab-panretinal-photocoagulation-and-subsequent-5-fluorouracil-augmented-trabeculectomy-a-case-report
#1
Xinyue Zhao, Zhi Wang, Xiaobo Yang
RATIONALE: Neovascular glaucoma (NVG) is one of the most refractory types of glaucoma caused by high ischemic retinal disorders, resulting in severe visual loss. Intravitreal injections of ranibizumab have been reported to have anatomical and functional success in treating NVG. PATIENT CONCERNS-DIAGNOSES-INTERVENTIONS: We report a case with neovascular glaucoma due to central retinal vein occlusion who received combination therapy with intravitreal ranibizumab (IVR) injection, panretinal photocoagulation (PRP) and subsequent 5-fluorouracil (5-FU) augmented trabeculectomy...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28626816/evaluation-of-topical-bevacizumab-as-an-adjunct-to-mitomycin-c-augmented-trabeculectomy
#2
Reza Zarei, Masoumeh Masoumpour, Sasan Moghimi, Ghasem Fakhraei, Yadollah Eslami, Masoud Mohammadi
PURPOSE: To investigate the safety and synergistic effect of topical bevacizumab after trabeculectomy surgery with mitomycin C (MMC). METHODS: In this prospective, non-randomized, comparative interventional study, 40 eyes from 40 patients with uncontrolled open-angle glaucoma were studied after they underwent primary trabeculectomy with mitomycin C (0.02% for 2 min). Following the procedure topical bevacizumab (4 mg/mL) was used for 2 weeks 4 times daily in group A...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28626446/gnrh-induces-erk-dependent-bleb-formation-in-gonadotrope-cells-involving-recruitment-of-members-of-a-gnrh-receptor-associated-signalosome-to-the-blebs
#3
Liat Rahamim-Ben Navi, Anna Tsukerman, Alona Feldman, Philippa Melamed, Melanija Tomić, Stanko S Stojilkovic, Ulrich Boehm, Rony Seger, Zvi Naor
We have previously described a signaling complex (signalosome) associated with the GnRH receptor (GnRHR). We now report that GnRH induces bleb formation in the gonadotrope-derived LβT2 cells. The blebs appear within ~2 min at a turnover rate of ~2-3 blebs/min and last for at least 90 min. Formation of the blebs requires active ERK1/2 and RhoA-ROCK but not active c-Src. Although the following ligands stimulate ERK1/2 in LβT2 cells: EGF > GnRH > PMA > cyclic adenosine monophosphate (cAMP), they produced little or no effect on bleb formation as compared to the robust effect of GnRH (GnRH > PMA > cAMP > EGF), indicating that ERK1/2 is required but not sufficient for bleb formation possibly due to compartmentalization...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28624462/evaluation-on-antiviral-activity-of-coumarin-derivatives-against-spring-viraemia-of-carp-virus-in-epithelioma-papulosum-cyprini-cells
#4
Lei Liu, Yang Hu, Yu-Feng Shen, Gao-Xue Wang
As one of the most serious pathogens in the freshwater aquatic environment, spring viraemia of carp virus (SVCV) can induce a high mortality rate in several cyprinid fishes. In this study, we designed and synthesized a total of 44 coumarin derivatives to evaluate the anti-SVCV activity. By comparing the inhibitory concentration at half-maximal activity (IC50), two imidazole coumarins (B4 and C2) were selected, with maximum inhibitory rates on SVCV more than 90%. Mechanistically, B4 or C2 did not affect viral adhesion and delivery from endosomes to the cytosol...
June 14, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28617656/sarcocystis-pantherophis-n-sp-from-eastern-rat-snakes-pantherophis-alleghaniensis-definitive-hosts-and-interferon-gamma-gene-knockout-mice-as-experimental-intermediate-hosts
#5
Shiv Verma, David Lindsay, Joseph Mowery, Benjamin Rosenthal, J P Dubey
Here we report a new species, Sarcocystis pantherophisi n. sp. with the Eastern rat snake (Pantherophis alleghaniensis) as natural definitive host and the interferon gamma gene knockout (KO) mouse as the experimental intermediate host. Sporocysts (n = 15) from intestinal contents of the snake were 17.3 x 10.9 µm. Sporocysts were orally infective to interferon gamma KO mice but not to laboratory raised albino outbred house mice (Mus musculus). The interferon gamma KO mice developed schizont-associated neurological signs and schizonts were cultivated in vitro from the brain...
June 15, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28615876/microscopic-investigation-to-determine-the-effect-of-beauveria-bassiana-bals-vuill-and-cymbopogon-citratus-dc-stapf-treatment-on-different-life-stages-of-musca-domestica-l
#6
Sapna Mishra, Peeyush Kumar, Anushree Malik
Microscopic investigation was done to determine the effect of entomopathogenic fungi, Beauveria bassiana and essential oil of Cymbopogon citratus on different life stages of Musca domestica. Scanning electron microscopy investigation of fungal infected larvae showed sluggish movement, rigor, and failure of body to balance in water. Treated larvae also revealed varied level of cuticle shrinkage and extreme dehydration. Surface of B. bassiana infected pupae showed varied stage of mycelial growth, while the cadaver of adult fly was observed to have extensive fungal growth covering their entire body surface...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28615113/risk-factors-and-long-term-outcomes-in-patients-with-low-intraocular-pressure-after-trabeculectomy
#7
Victoria L Tseng, Carole H Kim, Pablo T Romero, Fei Yu, Kenneth W Robertson-Brown, Lam Phung, Daniel Raygoza, Joseph Caprioli, Anne L Coleman
PURPOSE: To examine risk factors for low intraocular pressure (IOP) after trabeculectomy and to describe long-term outcomes in these eyes. DESIGN: Retrospective case-control study. PARTICIPANTS: Cases with low IOP included all patients with IOP ≤5 mmHg on 3 or more consecutive visits 3 months or later after trabeculectomy. Control patients without low IOP after trabeculectomy were randomly selected at a 1:2 case-to-control ratio. METHODS: A case-control study was performed of patients undergoing trabeculectomy at the Stein Eye Institute...
June 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28608271/repeated-subretinal-surgery-and-removal-of-subretinal-decalin-is-well-tolerated-evidence-from-a-porcine-model
#8
Nina Buus Sørensen, Kristian Klemp, Troels Wesenberg Kjær, Steffen Heegaard, Morten la Cour, Jens Folke Kiilgaard
PURPOSE: Subretinal perfluorocarbon liquid (PFCL) is a serious complication that can occur after retinal detachment repair. It is possible to remove the PFCL surgically, but retinal damage related to the procedure is unknown. Also, increasing interest in subretinal treatment makes it relevant to examine the functional and morphological consequences of repeated subretinal manipulation. We hypothesized that PFCL in a porcine model can be injected in the subretinal space and removed with minimal effect on retinal structure and function...
June 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28600745/safety-and-effectiveness-of-gold-glaucoma-micro-shunt-for-reducing-intraocular-pressure-in-japanese-patients-with-open-angle-glaucoma
#9
Masaki Tanito, Etsuo Chihara
PURPOSE: To assess the safety and effectiveness of the SOLX gold shunt (GS) in reducing intraocular pressure (IOP) in Japanese patients with open angle glaucoma (OAG). METHODS: 24 eyes of 24 subjects [mean age of 68.9 ± 12.7 years; 13 (54%) women; 16 (67%) POAG, 7 (29%) pseudoexfoliation glaucoma, and 1 (4%) steroid response glaucoma] were implanted with the GS either with or without cataract surgery. Best-corrected visual acuity (BCVA), IOP, corneal endothelial cell density (CECD), anterior chamber (AC) flare, surgical complications, and required interventions were monitored at baseline, and 1 day, 1 week, 1, 3 and 6 months, and 1 year postoperatively...
June 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28597562/reprogramming-progeria-fibroblasts-re-establishes-a-normal-epigenetic-landscape
#10
Zhaoyi Chen, Wing Y Chang, Alton Etheridge, Hilmar Strickfaden, Zhigang Jin, Gareth Palidwor, Ji-Hoon Cho, Kai Wang, Sarah Y Kwon, Carole Doré, Angela Raymond, Akitsu Hotta, James Ellis, Rita A Kandel, F Jeffrey Dilworth, Theodore J Perkins, Michael J Hendzel, David J Galas, William L Stanford
Ideally, disease modeling using patient-derived induced pluripotent stem cells (iPSCs) enables analysis of disease initiation and progression. This requires any pathological features of the patient cells used for reprogramming to be eliminated during iPSC generation. Hutchinson-Gilford progeria syndrome (HGPS) is a segmental premature aging disorder caused by the accumulation of the truncated form of Lamin A known as Progerin within the nuclear lamina. Cellular hallmarks of HGPS include nuclear blebbing, loss of peripheral heterochromatin, defective epigenetic inheritance, altered gene expression, and senescence...
June 8, 2017: Aging Cell
https://www.readbyqxmd.com/read/28592362/toxoplasma-gondii-apoptosis-and-cellular-division-alterations-after-in-vitro-treatment-with-copper-ii-complexes
#11
J A Portes, C S Motta, N F Azeredo, C Fernandes, A Horn, W De Souza, R A DaMatta, S H Seabra
Toxoplasma gondii is the causative agent of toxoplasmosis, which is one of the most common parasitic diseases in the world. Toxoplasmosis causes severe damage to immunocompromised hosts, and the most frequently used therapy is the combination of pyrimethamine and sulfadiazine, which has side effects. Thus, there is a need for new therapies that target T. gondii. Herein, we present the anti-Toxoplasma effect of two new copper(II) complexes: [(H2L1) Cu (μ-Cl)2 Cu(H2L1)] Cl2·5H2O (1) and [(H2L2) Cu (μ-Cl)2 Cu(H2L2)] Cl2·6H2O (2)...
April 20, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28587399/cytotoxic-and-apoptotic-activities-of-black-widow-spiderling-extract-against-hela-cells
#12
Xiaozhen Peng, Zhipan Dai, Qian Lei, Long Liang, Shuai Yan, Xianchun Wang
Black widow spiders contain toxic components not only in the venom glands but also in other parts of the spider body, including the legs and abdomen. Additionally, both the eggs and newborn spiderlings of the black widow spider contain venom. It is important to investigate their potential effects on cancer cells. In the present study, the effects of newborn black widow spiderling extract on human HeLa cells were evaluated in vitro. When applied at different concentrations, the total extract decreased HeLa cell viability in a dose-dependent manner, with an IC50 value of 158 µg/ml...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28586797/in-vivo-confocal-imaging-of-the-conjunctiva-as-a-predictive-tool-for-the-glaucoma-filtration-surgery-outcome
#13
Rodolfo Mastropasqua, Vincenzo Fasanella, Lorenza Brescia, Francesco Oddone, Cesare Mariotti, Silvio Di Staso, Luca Agnifili
Purpose: To examine the preoperative conjunctival dendritic cell density (DCD), goblet cell density (GCD), and stromal meshwork reflectivity (SMR) in glaucomatous patients undergoing filtration surgery, using in vivo confocal microscopy (IVCM). Methods: Sixty-six patients were enrolled. At baseline, IVCM was performed at the site planned for surgery, and was repeated after 12 months at bleb site. Surgery was successful when a one-third reduction of baseline IOP was obtained at the last follow-up...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28583831/investigations-into-the-killing-activity-of-an-antimicrobial-peptide-active-against-extensively-antibiotic-resistant-k-pneumoniae-and-p-aeruginosa
#14
Hessel van der Weide, Jlenia Brunetti, Alessandro Pini, Luisa Bracci, Chiara Ambrosini, Pietro Lupetti, Eugenio Paccagnini, Mariangela Gentile, Andrea Bernini, Neri Niccolai, Denise Vermeulen-de Jongh, Irma A J M Bakker-Woudenberg, Wil H F Goessens, John P Hays, Chiara Falciani
SET-M33 is a multimeric antimicrobial peptide active against Gram-negative bacteria in vitro and in vivo. Insights into its killing mechanism could elucidate correlations with selectivity. SET-M33 showed concentration-dependent bactericidal activity against colistin-susceptible and resistant isolates of P. aeruginosa and K. pneumoniae. Scanning and transmission microscopy studies showed that SET-M33 generated cell blisters, blebs, membrane stacks and deep craters in K. pneumoniae and P. aeruginosa cells. NMR analysis and CD spectra in the presence of sodium dodecyl sulfate micelles showed a transition from an unstructured state to a stable α-helix, driving the peptide to arrange itself on the surface of micelles...
June 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28574500/subconjunctival-implantation-of-ologen-collagen-matrix-to-treat-ocular-hypotony-after-filtration-glaucoma-surgery
#15
M Tanito, A Okada, Y Mori, I Sano, Y Ikeda, E Fujihara
PurposeTo report the results of subconjunctival ologen Collagen Matrix implantation to manage ocular hypotony after filtration glaucoma surgery.Patients and methodsThis retrospective observational case series included 12 consecutive implantations of ologen in nine eyes of nine Japanese subjects (five men, four women; mean age±SD, 72.1±12.7 years) who underwent subconjunctival implantation of the device to treat hypotony after glaucoma filtration surgery. Demographic data and surgical results were collected by chart review...
June 2, 2017: Eye
https://www.readbyqxmd.com/read/28569085/acrylamide-derived-cytotoxic-anti-proliferative-and-apoptotic-effects-on-a549-cells
#16
S Kacar, D Vejselova, H M Kutlu, V Sahinturk
BACKGROUND: Acrylamide is a very common compound even reaching up to our daily foods. It has been studied in a wealth of cell lines on which it proved to have various toxic effects. Among these cell lines, human lung adenocarcinoma cell line (A549) is one of that on which acrylamide's toxicity has not been studied well yet. AIM: We intended to determine the half maximal inhibitory concentration (IC50) dose of acrylamide and to investigate its cytotoxic, anti-proliferative and apoptotic effects on A549 cells...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28557611/lamin-a-and-microtubules-collaborate-to-maintain-nuclear-morphology
#17
Zeshan Tariq, Haoyue Zhang, Alexander Chia-Liu, Yang Shen, Yantenew Gete, Zheng-Mei Xiong, Claire Tocheny, Leonard Campanello, Di Wu, Wolfgang Losert, Kan Cao
Lamin A (LA) is a critical structural component of the nuclear lamina. Mutations within the LA gene (LMNA) lead to several human disorders, most striking of which is Hutchinson-Gilford Progeria Syndrome (HGPS), a premature aging disorder. HGPS cells are best characterized by an abnormal nuclear morphology known as nuclear blebbing, which arises due to the accumulation of progerin, a dominant mutant form of LA. The microtubule (MT) network is known to mediate changes in nuclear morphology in the context of specific events such as mitosis, cell polarization, nucleus positioning and cellular migration...
May 30, 2017: Nucleus
https://www.readbyqxmd.com/read/28555041/the-effect-of-dry-eye-disease-on-scar-formation-in-rabbit-glaucoma-filtration-surgery
#18
Hong Ji, Yingting Zhu, Yingying Zhang, Yu Jia, Yiqing Li, Jian Ge, Yehong Zhuo
The success rate of glaucoma filtration surgery is closely related to conjunctival inflammation, and the main mechanism of dry eye disease (DED) is inflammation. The aim of this study was to evaluate the effect of DED on bleb scar formation after rabbit glaucoma filtration surgery. Sixteen New Zealand white rabbits were randomly divided into control and DED groups. A DED model was induced by twice-daily topical administration of 0.1% benzalkonium chloride (BAC) drops for three weeks. Ocular examinations were performed to verify the DED model...
May 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28552580/engineered-proteins-program-mammalian-cells-to-target-inflammatory-disease-sites
#19
Anam Qudrat, Abdullah Al Mosabbir, Kevin Truong
Disease sites in atherosclerosis and cancer feature cell masses (e.g., plaques/tumors), a low pH extracellular microenvironment, and various pro-inflammatory cytokines such as tumor necrosis factor α (TNFα). The ability to engineer a cell to seek TNFα sources allows for targeted therapeutic delivery. To accomplish this, here we introduced a system of proteins: an engineered TNFα chimeric receptor (named TNFR1chi), a previously engineered Ca(2+)-activated RhoA (named CaRQ), vesicular stomatitis virus glycoprotein G (VSVG), and thymidine kinase...
June 22, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28542372/revision-of-encapsulated-blebs-after-trabeculectomy-long-term-comparison-of-standard-bleb-needling-and-modified-needling-procedure-combined-with-transconjunctival-scleral-flap-sutures
#20
P Laspas, P D Culmann, F H Grus, V Prokosch-Willing, A Poplawksi, N Pfeiffer, E M Hoffmann
PURPOSE: To compare two surgical approaches for treating encapsulated blebs after trabeculectomy with mitomycin C, in terms of the development of intraocular pressure and progression of glaucoma in a long-term follow up: 1. bleb needling alone vs. 2. a combined approach of needling with additional transconjunctival scleral flap sutures, to prevent early ocular hypotony. METHODS: Forty-six patients with failing blebs after trabeculectomy with mitomycin C were enrolled in this study...
2017: PloS One
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