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https://www.readbyqxmd.com/read/27929714/unusual-surprises-in-glaucoma-filtering-surgeries-lessons-learned-and-review-of-literature
#1
Aparna Rao, Debananda Padhy, Avik Kumar Roy, Sirisha Senthil
PURPOSE: To describe an unusual series of complications after glaucoma filtering surgeries with their clinical findings and outcome after tailored non-conventional modes of therapy. PATIENTS AND METHODS: Eighteen patients who underwent re-interventions (medical or surgical) after glaucoma filtering surgeries during the period at two tertiary centers, excluding those that required conventional modes of treatment (medical control or re-trabeculectomy, simple wound closure for traumatic wound dehiscence, bleb revision or needling, laser iridotomy), were included...
December 8, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27920588/appraisal-of-bleb-using-trio-of-intraocular-pressure-morphology-on-slit-lamp-and-gonioscopy
#2
Shreya Thatte, Rimpi Rana, Neeraj Gaur
PURPOSE: The aim of this study was to assess bleb function using Wuerzburg bleb classification score (WBCS) for bleb morphology on slit lamp, intraocular pressure (IOP), and gonioscopy. METHODS: A total of randomly selected 30 eyes posttrabeculectomy were assessed for bleb function with the trio of bleb morphology, IOP, and gonioscopy. Bleb was assessed using the WBCS of 0-12 on slit lamp, IOP was assessed using applanation tonometry, and visualization of inner ostium and iridectomy were assessed using gonioscopy...
2016: Ophthalmology and Eye Diseases
https://www.readbyqxmd.com/read/27920489/bleb-related-infections-clinical-characteristics-risk-factors-and-outcomes-in-an-asian-population
#3
Zhu Li Yap, You Chuen Chin, Judy Yu-Fen Ku, Tat Keong Chan, Gillian Teh, Monisha Esther Nongpiur, Tin Aung, Shamira A Perera
PURPOSE: Comparison of the demographic, ocular, systemic and microbiological characteristics of eyes with bleb related infection (BRI) and bleb related endophthalmitis (BRE). METHODS: Retrospective chart review of patients with BRI from January 1996-July 2013. Identification done via the center's longstanding endophthalmitis audit, BRI audit and laboratory database identifying all conjunctival swabs from blebs. Blebitis was defined as anterior segment inflammation with mucopurulent material in or around the bleb, with anterior chamber cells but no hypopyon...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27910904/melanosome-transfer-to-keratinocyte-in-the-chicken-embryonic-skin-is-mediated-by-vesicle-release-associated-with-rho-regulated-membrane-blebbing
#4
Ryosuke Tadokoro, Hidetaka Murai, Ken-Ichiro Sakai, Takahiro Okui, Yasuhiro Yokota, Yoshiko Takahashi
During skin pigmentation in amniotes, melanin synthesized in the melanocyte is transferred to keratinocytes by a particle called the melanosome. Previous studies, mostly using dissociated cultured cells, have proposed several different models that explain how the melanosome transfer is achieved. Here, using a technique that labels the plasma membrane of melanocytes within a three-dimensional system that mimics natural tissues, we have visualized the plasma membrane of melanocytes with EGFP in chicken embryonic skin...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905335/incidence-of-short-term-complications-and-associated-factors-after-primary-trabeculectomy-in-chiang-mai-university-hospital
#5
Thidarat Leeungurasatien, Preeyanuch Khunsongkiet, Kassara Pathanapitoon, Damrong Wiwatwongwana
BACKGROUND: To determine the incidence of early postoperative complications and associated factors after primary trabeculectomy in Thai glaucoma patients. DESIGN: This was a retrospective observational study performed in Chiang Mai University Hospital. PARTICIPANTS: One hundred and eighteen glaucoma patients participated in the study. METHODS: All glaucoma patients underwent primary trabeculectomy with mitomycin C (MMC) using fornix-based conjunctival flap technique between December 2011 and May 2013...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27896557/cytotoxic-and-apoptotic-activities-of-extract-of-amaranthus-spinosus-l-in-allium-cepa-and-human-erythrocytes
#6
V Prajitha, J E Thoppil
The present study examined the apoptosis inducing effects of Amaranthus spinosus L. aqueous extract in Allium cepa root meristematic cells and human erythrocytes. Cytogenetic assay revealed many apoptosis inducing cytogenetic aberrations viz., cytoplasmic breakage, cytoplasmic disintegration, cytoplasmic shrinkage, receding of cytoplasm, cytoplasmic vacuolation, enucleated cell, ghost cell, nuclear vacuolation, nuclear fragmentation and nuclear disintegration. A remarkable modification of red blood cell surface morphology was observed in the result of RBC assay...
November 28, 2016: Cytotechnology
https://www.readbyqxmd.com/read/27893886/integrin-%C3%AE-5%C3%AE-1-inhibition-by-clt-28643-reduces-postoperative-wound-healing-in-a-mouse-model-of-glaucoma-filtration-surgery
#7
Tine Van Bergen, Grit Zahn, Patrizia Caldirola, Mario Fsadni, Ninus Caram-Lelham, Evelien Vandewalle, Lieve Moons, Ingeborg Stalmans
Purpose: To evaluate the therapeutic potential of the small molecule integrin α5β1 inhibitor, CLT-28643, to improve the filtering surgery outcome in a mouse model. Different dose regimens and administration routes of the inhibitor were compared with mitomycin C (MMC), the gold standard in clin ical practice. Methods: The efficacy of CLT-28643 on surgical outcome was studied in a mouse model for filtering surgery (n = 40 eyes from 20 mice per group). Single and repeated subconjunctival (SCJ) injections (1 or 2 μg) and topical eye drops (10 μg) of the integrin inhibitor were compared with 2-minute administration of MMC 0...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27889376/the-cytoplasmic-domain-of-mt1-mmp-is-dispensable-for-migration-augmentation-but-necessary-to-mediate-viability-of-mcf-7-breast-cancer-cells
#8
Mario A Cepeda, Jacob Jh Pelling, Caitlin L Evered, Hon S Leong, Sashko Damjanovski
Membrane-type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease that regulates ECM degradation, proMMP-2 activation, and varied cellular processes including migration and viability. MT1-MMP is believed to be a central mediator of tumourigenesis whose role is dictated by its functionally distinct protein domains. Both the localization and signal transduction capabilities of MT1-MMP are dependent on its cytoplasmic domain, exemplifying diverse regulatory functions. To further our understanding of the multifunctional contributions of MT1-MMP to cellular processes, we overexpressed cytoplasmic domain altered constructs in MCF-7 breast cancer cells and analyzed migration and viability in 2D culture conditions, morphology in 3D Matrigel culture, and tumorigenic ability in vivo...
November 23, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27882440/hemodynamic-changes-in-a-middle-cerebral-artery-aneurysm-at-follow-up-times-before-and-after-its-rupture-a-case-report-and-a-review-of-the-literature
#9
A Sejkorová, K D Dennis, H Švihlová, O Petr, G Lanzino, A Hejčl, D Dragomir-Daescu
Hemodynamic parameters play a significant role in the development of cerebral aneurysms. Parameters such as wall shear stress (WSS) or velocity could change in time and may contribute to aneurysm growth and rupture. However, the hemodynamic changes at the rupture location remain unclear because it is difficult to obtain data prior to rupture. We analyzed a case of a ruptured middle cerebral artery (MCA) aneurysm for which we acquired imaging data at three time points, including at rupture. A patient with an observed MCA aneurysm was admitted to the emergency department with clinical symptoms of a subarachnoid hemorrhage...
November 24, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27879436/cytological-bone-marrow-cell-differential-counts-and-morphologic-findings-in-healthy-cynomolgus-monkeys-macaca-fascicularis-from-nonclinical-toxicology-studies
#10
Caitlyn M Carter, Laura C Cregar, Adam D Aulbach
Cytological bone marrow evaluation is utilized in nonclinical toxicology studies to characterize hematopoietic effects when the combined interpretation of histologic and complete blood count data does not yield sufficient information. Results from cytological bone marrow examination should be interpreted in the context of variability observed in concurrent control animals with consideration of cytologist experience and historical/published data. Cytological bone marrow differential counts and cellular morphologic findings from 130 (66 male, 64 female) healthy control cynomolgus monkeys from nonclinical toxicology studies were retrospectively analyzed...
November 22, 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27877086/ginsenoside-rg1-protects-against-oxidative-stress-induced-neuronal-apoptosis-through-myosin-iia-actin-related-cytoskeletal-reorganization
#11
Yan Wang, Qian Liu, Yingqiong Xu, Yuanyuan Zhang, Yanni Lv, Yisha Tan, Nan Jiang, Guosheng Cao, Xiaonan Ma, Jingrong Wang, Zhengyu Cao, Boyang Yu, Junping Kou
Oxidative stress-induced cytoskeletal dysfunction of neurons has been implicated as a crucial cause of cell apoptosis or death in the central nervous system (CNS) diseases, such as neurodegenerative and psychiatric diseases. The application of neuroprotectants rescuing the neurons from cytoskeletal damage and apoptosis can be a potential treatment for these CNS diseases. Ginsenoside Rg1 (Rg1), one of the major active components of ginseng, has been reported possessing notable neuroprotective activities. However, there is rare report about its effect on cytoskeleton and its undergoing mechanism...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27875350/pediatric-glaucoma-review-of-recent-literature
#12
Annette Giangiacomo, Allen Beck
PURPOSE OF REVIEW: The purpose of this review is to update the clinician on the recent work in the field of pediatric glaucoma. RECENT FINDINGS: Using the iCare tonometer to measure intraocular pressure (IOP) in children is highly successful. New data from the Infant Aphakia Treatment Study show that after 5 years of follow-up the risk of developing glaucoma is similar between patients that receive initial intraocular lens implantation and those who are left aphakic...
December 7, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27867571/role-of-oxidative-stress-and-outcome-of-various-surgical-approaches-among-patients-with-bullous-lung-disease-candidate-for-surgical-interference
#13
Ahmed Farouk, Mohammed H Hassan, Mohammed Alaa Nady, Mohammed Farouk Abdel Hafez
BACKGROUND: Bullous lung disease is characterized by formation of blebs, bullae and emphysema. We investigate the role of oxidative stress in the pathogenesis of bullous lung disease and compare between conventional thoracotomy versus video assisted thoracoscopic approach in surgical management of such patients. METHODS: This study was a prospective case control study and it was carried out on 21 patients (16 males and 5 females) with bullous lung disease selected as candidate for surgical interference...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27857488/porosity-of-bleb-capsule-declines-rapidly-with-fluid-challenge
#14
Surinder S Pandav, Craig M Ross, Faisal Thattaruthody, Ritambhra Nada, Nirbhai Singh, Natasha Gautam, Stephen Beirne, Gordon G Wallace, Mark B Sherwood, Jonathan G Crowston, Michael Coote
INTRODUCTION: The porosity of the fibrous capsule around a glaucoma drainage device (GDD) may be the most important functional attribute. The factors that determine capsular porosity are not well understood. Failed GDD surgeries are usually associated with thick impervious capsules and components of aqueous have been implicated in this process. PURPOSE: In this study, we interrogated the effect of passage of nonaqueous fluid on capsular porosity in mature (but aqueous naïve) blebs in a previously reported GDD model (the "Center for Eye Research Australia Implant")...
September 2016: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/27857486/blebs-barriers-and-bagpipes-why-is-it-so-hard
#15
Michael Coote
: Doug Johnson was a clinician-scientist who made great contributions to the understanding of outflow from the eye. This lecture is in honour of Doug and explores the author's understanding of outflow in the surgical context. HOW TO CITE THIS ARTICLE: Coote M. Blebs, Barriers, and Bagpipes: Why is It so Hard? J Curr Glaucoma Pract 2016; 10(3):79-84.
September 2016: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/27856617/pdgfr%C3%AE-regulates-craniofacial-development-through-homodimers-and-functional-heterodimers-with-pdgfr%C3%AE
#16
Katherine A Fantauzzo, Philippe Soriano
Craniofacial development is a complex morphogenetic process, disruptions in which result in highly prevalent human birth defects. While platelet-derived growth factor (PDGF) receptor α (PDGFRα) has well-documented functions in this process, the role of PDGFRβ in murine craniofacial development is not well established. We demonstrate that PDGFRα and PDGFRβ are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing...
November 17, 2016: Genes & Development
https://www.readbyqxmd.com/read/27855617/eryptosis-ally-or-enemy
#17
Marilena Briglia, Maria Antonia Rossi, Caterina Faggio
Prior to senescence, erythrocytes may, experience injury which compromises their integrity and thus triggers suicidal erythrocyte death or eryptosis. This mechanism is characterised by cell shrinkage, cell membrane blebbing, and cell membrane phospholipid scrambling after phosphatidylserine exposure on the cell surface that is identified by macrophages which engulf and degrade the eryptotic cells. The term eryptosis also includes typical mechanisms, which contribute to the triggering of this process. Among them: oxidative stress, Ca2+ entry with an increase in cytosolic Ca2+ activity ([Ca ]i) and the activation of p38 kinase, which is a kinase expressed in human erythrocytes and activated after hyperosmotic shock...
November 18, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27855213/effects-of-osmolality-on-paracellular-transport-in-mdck-ii-cells
#18
Shinsaku Tokuda, Toyohiro Hirai, Mikio Furuse
Epithelia separate apical and basal compartments, and movement of substances via the paracellular pathway is regulated by tight junctions. Claudins are major constituents of tight junctions and involved in the regulation of tight junction permeability. On the other hand, the osmolality in the extracellular environment fluctuates in association with life activity. However, effects of osmotic changes on the permeaibility of claudins are poorly understood. Therefore, we investigated the effects of osmotic changes on the paracellular transport in MDCK II cells...
2016: PloS One
https://www.readbyqxmd.com/read/27854239/kshv-entry-and-trafficking-in-target-cells-hijacking-of-cell-signal-pathways-actin-and-membrane-dynamics
#19
REVIEW
Binod Kumar, Bala Chandran
Kaposi's sarcoma associated herpesvirus (KSHV) is etiologically associated with human endothelial cell hyperplastic Kaposi's sarcoma and B-cell primary effusion lymphoma. KSHV infection of adherent endothelial and fibroblast cells are used as in vitro models for infection and KSHV enters these cells by host membrane bleb and actin mediated macropinocytosis or clathrin endocytosis pathways, respectively. Infection in endothelial and fibroblast cells is initiated by the interactions between multiple viral envelope glycoproteins and cell surface associated heparan sulfate (HS), integrins (α3β1, αVβ3 and αVβ5), and EphA2 receptor tyrosine kinase (EphA2R)...
November 14, 2016: Viruses
https://www.readbyqxmd.com/read/27852140/impact-of-pregnancy-on-the-size-of-small-cerebral-aneurysm
#20
Hiroaki Tanaka, Shinji Katsuragi, Kayo Tanaka, Naoko Iwanaga, Jun Yoshimatsu, Jun C Takahashi, Tomoaki Ikeda
OBJECTIVE: Because the management of cerebral aneurysms during pregnancy remains controversial, the objective of this study was to perform a retrospective review of pregnant women with cerebral aneurysms to determine whether pregnancy is a risk factor for aneurysm rupture. METHODS: The change in size of aneurysms during pregnancy was examined by performing repeat magnetic resonance angiography in 5 pregnant women with cerebral aneurysms between 2005 and 2013. The outcome examined was development of subarachnoid hemorrhage...
November 16, 2016: Journal of Maternal-fetal & Neonatal Medicine
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