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https://www.readbyqxmd.com/read/28816926/feasibility-and-relevance-of-antipsychotic-safety-monitoring-in-children-with-tourette-syndrome-a-prospective-longitudinal-study
#1
Tamara Pringsheim, Josephine Ho, Justyna R Sarna, Tracy Hammer, Scott Patten
PURPOSE/BACKGROUND: Antipsychotics are efficacious for tics and are increasingly prescribed to children with behavioral disorders. Antipsychotics have important adverse effects, and systematic monitoring of drug safety is infrequently performed. The objectives of this study were to determine the feasibility of antipsychotic safety monitoring in children with Tourette Syndrome using a defined protocol and to evaluate the risk of adverse effects with chronic use. METHODS/PROCEDURES: A prospective longitudinal study of children prescribed antipsychotics was performed...
August 14, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28816835/acute-worsening-of-tics-on-varenicline
#2
Shivam Om Mittal, Bryan T Klassen, Anhar Hassan, James H Bower, Elizabeth A Coon
OBJECTIVE: The aim of this study was to report worsening of Tourette syndrome (TS) in 2 patients treated with varenicline. BACKGROUND: Abnormal dopaminergic signaling is likely involved in the pathophysiology of TS. Varenicline is a partial α4β2 nicotinic acetylcholine agonist that enhances dopamine release. Therefore, the use of varenicline may influence tics in patients with TS. METHOD: We analyzed and described 2 case studies on patients with significant worsening of tics after treatment with varenicline...
August 14, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28815684/cognitive-psychophysiological-treatment-of-bodily-focused-repetitive-behaviors-in-adults-an-open-trial
#3
Kieron O'Connor, Marc Lavoie, Benoît Desaulniers, Jean-Sébastien Audet
BACKGROUND: Body-focused repetitive behaviors (BFRBs), such as hair pulling, skin picking, and nail biting, are repetitive, destructive, and nonfunctional habits that cause significant distress. Separate BFRBs form a cohesive group and could be assessed as part of the Tourette/tic spectrum or obsessive-compulsive spectrum of disorders. The treatment of choice is either antidepressant or behavioral treatment, both of which have shown effectiveness. The cognitive psychophysiological (CoPs) model focuses on the tension and emotional build up that triggers habits by addressing cognitive-behavioral, emotional and psychophysiological processes preceding onset rather than the habit itself...
August 16, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28807495/the-colorful-spectrum-of-tourette-syndrome-and-its-medical-surgical-and-behavioral-therapies
#4
Jan Roth
Tourette syndrome (TS) is a common neuropsychiatric disorder, more common in males than females, with onset before age 18. TS is characterized by multiple motor tics and one or more vocal/phonic tics, persisting for more than a year. Tics are unvoluntary, abrupt, rapid, repetitive, but non-rhythmic movements or sounds (vocalizations). They are preceded by an inner urge. Tics can be temporarily suppressed, but this leads to a powerful re-emergence. The performance of tics results in immediate but transient relief...
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28805580/tourette-syndrome-and-chronic-tic-disorders-the-clinical-spectrum-beyond-tics
#5
Davide Martino, Christos Ganos, Tamara M Pringsheim
The clinical surveillance and active management of Tourette syndrome (TS) and other primary chronic tic disorders cannot be limited to tics, as these patients manifest a spectrum of sensory-, behavioral-, cognitive-, and sleep-related problems that have a major impact on their functioning and quality of life, influencing enormously clinical decision making on a routine basis. The sensory phenomena of primary tic disorders consist of premonitory urges and heightened sensitivity to external somatosensory and interoceptive stimuli...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28801977/isolation-identification-and-characterization-of-lignin-degrading-bacteria-from-qinling-china
#6
C-X Yang, T Wang, L-N Gao, H-J Yin, X Lü
AIMS: Lignin is an aromatic heteropolymer forming a physical barrier and is a big challenge in biomass utilization. This paper firstly investigated lignin-degradation bacteria from rotten wood in Qinling Mountain. METHODS AND RESULTS: 19 potential strains were selected and ligninolytic enzyme activities were determined during 84 h. The strains which had higher enzymes activities were selected. Further the biodegradation of wheat straw lignin and alkali lignin was evaluated, which indicated Burkholderia sp...
August 12, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28801636/inhibition-of-hypoxic-response-decreases-stemness-and-reduces-tumorigenic-signaling-due-to-impaired-assembly-of-hif1-transcription-complex-in-pancreatic-cancer
#7
Olivia McGinn, Vineet K Gupta, Patricia Dauer, Nivedita Arora, Nikita Sharma, Alice Nomura, Vikas Dudeja, Ashok Saluja, Sulagna Banerjee
Pancreatic tumors are renowned for their extremely hypoxic centers, resulting in upregulation of a number of hypoxia mediated signaling pathways including cell proliferation, metabolism and cell survival. Previous studies from our laboratory have shown that Minnelide, a water-soluble pro-drug of triptolide (anti-cancer compound), decreases viability of cancer cells in vitro as well as in vivo. However, its mechanism of action remain elusive. In the current study we evaluated the effect of Minnelide, on hypoxia mediated oncogenic signaling as well as stemness in pancreatic cancer...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801514/bilateral-painful-tic-convulsif
#8
Valentina Fenech, Julian Cassar, Ludvic Zrinzo, Malcolm Vella
'Painful tic convulsif' (PTC) describes the coexistence of hemifacial spasm and trigeminal neuralgia. In this report, we describe a unique presentation of bilateral PTC in a man with bilateral hemifacial spasm and trigeminal neuralgia secondary to neurovascular conflict of all four cranial nerves. Following failed medical and radiofrequency therapy, microvascular decompression of three of the four involved nerves was performed, where the offending vessels were mobilised and Teflon used to prevent conflict recurrence...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28798371/evidence-for-enhanced-multi-component-behaviour-in-tourette-syndrome-an-eeg-study
#9
Valerie C Brandt, Ann-Kathrin Stock, Alexander Münchau, Christian Beste
Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-component behaviour was collected from 15 patients with Tourette syndrome (mean age = 30.40 ± 11.10) and 15 healthy controls (27.07 ± 5.44), using the stop-change task. In this task, participants are asked to sometimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative Go stimulus (change cue)...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796977/a-novel-de-novo-20q13-11q13-12-microdeletion-in-a-boy-with-neurodevelopmental-disorders-case-report
#10
Joanna Bernaciak, Barbara Wiśniowiecka-Kowalnik, Jennifer Castañeda, Anna Kutkowska-Kaźmierczak, Beata Nowakowska
Copy-number variants (CNVs) are an important cause of human neurodevelopmental disorders. We present the first case of a 424 kb de novo 20q13.11q13.12 microdeletion in a patient with attention deficit disorder, tics and autistic behaviors, such as emotional and behavioral problems, and movement stereotypes. This region includes three genes expressed in the brain: SFRS6, PTPRT and L3MBTL. Our results suggest that loss of the chromosomal region 20q13.11q13.12 is causative for the clinical findings observed in the patient...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28796166/speechlessness-in-gilles-de-la-tourette-syndrome-cannabis-based-medicines-improve-severe-vocal-blocking-tics-in-two-patients
#11
Ewgeni Jakubovski, Kirsten Müller-Vahl
We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical cannabis at a dose of 1 × 0.1 g cannabis daily. Case 2: a 16-year old patient initially received dronabinol at a maximum dose of 22.4-33.6 mg daily. Both treatments provided significant symptom improvement of vocal blocking tics as well as of comorbid conditions and were well tolerated...
August 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28796062/usefulness-of-anterior-cervical-fusion-using-titanium-interbody-cage-for-treatment-of-cervical-degenerative-disease-with-preoperative-segmental-kyphosis
#12
Kunihiko Hosoi, Hitoshi Tonomura, Ryota Takatori, Masateru Nagae, Yasuo Mikami, Toru Osawa, Yuji Arai, Hiroyoshi Fujiwara, Toshikazu Kubo
Favorable bone fusion and clinical results have been reported for anterior cervical fusion (ACF) using titanium interbody cage (TIC). This method might induce postoperative subsidence and local kyphosis, but the relationship between radiological changes and preoperative local alignment is not known. The purpose of the present study is to investigate the impact of preoperative local alignment on the clinical and radiological outcomes of ACF using TIC.The study enrolled 36 patients (mean age 49.8 years) who underwent single-level ACF using TIC for cervical degenerative diseases...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28789621/tics-as-an-initial-manifestation-of-juvenile-huntington-s-disease-case-report-and-literature-review
#13
Shi-Shuang Cui, Ru-Jing Ren, Ying Wang, Gang Wang, Sheng-Di Chen
BACKGROUND: Huntington's disease (HD) is an autosomal dominant disorder, typically characterized by chorea due to a trinucleotide repeat expansion in the HTT gene, although the clinical manifestations of patients with juvenile HD (JHD) are atypical. CASE PRESENTATION: A 17-year-old boy with initial presentation of tics attended our clinic and his DNA analysis demonstrated mutation in the HTT gene (49 CAG repeats). After treatment, his symptoms improved. Furthermore, we performed literature review through searching the databases and summarized clinical features in 33 JHD patients...
August 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28775146/inhibition-of-the-v-atpase-by-archazolid-a-a-new-strategy-to-inhibit-emt
#14
Henriette Merk, Philipp Messer, Maximilian A Ardelt, Don C Lamb, Stefan Zahler, Rolf Müller, Angelika M Vollmar, Johanna Pachmayr
Epithelial-mesenchymal transition (EMT) induces tumor-initiating cells (TICs) which account for tumor recurrence, metastasis and therapeutic resistance. Strategies to interfere with EMT are rare but urgently needed to improve cancer therapy. By using the myxobacterial natural compound Archazolid A as a tool, we elucidate the V-ATPase, a multimeric proton pump that regulates lysosomal acidification, as a crucial player in EMT and identify the inhibition of V-ATPase by Archazolid A as promising strategy to block EMT...
August 3, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28774611/tic-tox-a-preliminary-discussion-on-identifying-the-forcing-agents-of-dbp-mediated-toxicity-of-disinfected-water
#15
Michael J Plewa, Elizabeth D Wagner, Susan D Richardson
The disinfection of drinking water is a major public health achievement; however, an unintended consequence of disinfection is the generation of disinfection by-products (DBPs). Many of the identified DBPs exhibit in vitro and in vivo toxicity, generate a diversity of adverse biological effects, and may be hazards to the public health and the environment. Only a few DBPs are regulated by several national and international agencies and it is not clear if these regulated DBPs are the forcing agents that drive the observed toxicity and their associated health effects...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28774039/influence-of-sintering-temperature-on-the-microstructure-and-mechanical-properties-of-in-situ-reinforced-titanium-composites-by-inductive-hot-pressing
#16
Cristina Arévalo, Isabel Montealegre-Meléndez, Enrique Ariza, Michael Kitzmantel, Cristina Rubio-Escudero, Erich Neubauer
This research is focused on the influence of processing temperature on titanium matrix composites reinforced through Ti, Al, and B₄C reactions. In order to investigate the effect of Ti-Al based intermetallic compounds on the properties of the composites, aluminum powder was incorporated into the starting materials. In this way, in situ TixAly were expected to form as well as TiB and TiC. The specimens were fabricated by the powder metallurgy technique known as inductive hot pressing (iHP), using a temperature range between 900 °C and 1400 °C, at 40 MPa for 5 min...
November 11, 2016: Materials
https://www.readbyqxmd.com/read/28774025/the-microwave-assisted-green-synthesis-of-tic-powders
#17
Hui Wang, Wencheng Zhu, Yanchun Liu, Lingke Zeng, Luyi Sun
Titanium carbide (TiC) is an important engineering material and has found widespread applications. Currently, TiC is typically synthesized through carbothermal reduction, requiring a high temperature (ca. 1700-2300 °C) and long reaction time (ca. 10-20 h), which is not eco-friendly. During a conventional reaction path, anatase TiO₂ (A-TiO₂) was first converted to rutile TiO₂ (R-TiO₂), which was subsequently reduced to TiC. Herein, we explored the synthesis of TiC powders with the assistance of microwave heating...
November 8, 2016: Materials
https://www.readbyqxmd.com/read/28773934/tic-reinforcement-composite-coating-produced-using-graphite-of-the-cast-iron-by-laser-cladding
#18
Yanhui Liu, Weicheng Qu, Yu Su
In this study, a TiC-reinforced composite coating was produced to improve the wear resistance of a pearlite matrix grey iron using a pre-placed Ti powder by laser cladding. Results of scanning electron microscopy (SEM), X-ray diffractometer (XRD), and energy dispersive X-ray spectroscopy (EDS) confirmed that the coating was composed of TiC particles and two kinds of α-Fe phase. The fine TiC particles were only a few microns in size and uniformly distributed on the matrix phase in the composite coating. The microstructure characteristic of the composite coating resulted in the microhardness rising to about 1000 HV0...
September 30, 2016: Materials
https://www.readbyqxmd.com/read/28773827/study-on-the-impact-resistance-of-bionic-layered-composite-of-tic-tib%C3%A2-al-from-al-ti-b%C3%A2-c-system
#19
Qian Zhao, Yunhong Liang, Zhihui Zhang, Xiujuan Li, Luquan Ren
Mechanical property and impact resistance mechanism of bionic layered composite was investigated. Due to light weight and high strength property, white clam shell was chosen as bionic model for design of bionic layered composite. The intercoupling model between hard layer and soft layer was identical to the layered microstructure and hardness tendency of the white clam shell, which connected the bionic design and fabrication. TiC-TiB₂ reinforced Al matrix composites fabricated from Al-Ti-B₄C system with 40 wt...
August 20, 2016: Materials
https://www.readbyqxmd.com/read/28773140/microstructures-and-properties-of-plasma-sprayed-ni-based-coatings-reinforced-by-tin-c1-xnxti-generated-from-in-situ-solid-gas-reaction
#20
Wenquan Wang, Wenmo Li, Hongyong Xu
The strengthening hard phases TiN/C1-xNxTi were generated by in-situ solid-gas reaction in Ni-based composite coatings prepared using a plasma spray welding process to reinforce the wear resistance of the coatings. The microstructures and properties of the coatings were investigated. The results showed that the coatings mainly consisted of phases such as TiN, C1-xNxTi, TiC, etc. A small amount of CrB, M₇C₃, and M23C₆ were also detected in the coatings by micro-analysis method. Compared with the originally pure NiCrBSi coatings, the hardness of the NiCrBSi coatings reinforced by in-situ solid-gas reaction was 900 HV0...
July 11, 2017: Materials
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