Read by QxMD icon Read


Valentina Cuccio, Vittorio Gallese
The nature of concepts has always been a hotly debated topic in both philosophy and psychology and, more recently, also in cognitive neuroscience. Different accounts have been proposed of what concepts are. These accounts reflect deeply different conceptions of how the human mind works. In the last decades, two diametrically opposed theories of human cognition have been discussed and empirically investigated: the Computational Theory of Mind, on the one hand (Fodor 1983 The modularity of mind: an essay on faculty psychology ; Pylyshyn 1984 Computation and cognition: toward a foundation for cognitive science ), and Embodied Cognition (Barsalou 2008 Annu...
August 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Zhengyang Chen, Shufeng Yang, Jingshe Li, Hao Guo, Hongbo Zheng
Hot working is a key process in the production of superalloys; however, it may result in the formation of inclusions that affect the superalloy performance. Therefore, the effects of hot working on inclusions in a superalloy must be studied. GH4738 superalloy was manufactured, herein, by vacuum induction melting and vacuum arc remelting. Hot working was performed by unidirectional drawing, upsetting and drawing, and upsetting/drawing with radial forging. The types and distributions of inclusions after these three hot working processes and those in an original ingot were analyzed using scanning electron microscopy, energy dispersive spectroscopy, and Image-Pro Plus software...
June 15, 2018: Materials
Axel Sauter, Harald Breivik
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li, Bo Xiang
BACKGROUND: Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs. MAIN BODY: Recent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs...
June 15, 2018: Journal of Experimental & Clinical Cancer Research: CR
Lourdes M DelRosso, Kenneth Martin, Oliviero Bruni, Raffaele Ferri
INTRODUCTION: For several years, pineal cysts have been considered an incidental finding on brain MRI's even though research and case reports have shown a possible association of pineal cysts with headaches and sleep disturbances. This pilot study aims to evaluate sleep disorders in school-age children with an incidental pineal cyst in an otherwise normal brain MRI. METHOD: Children aged 6-12 years, who were referred for evaluation of headaches, tics, or syncope, and had an incidental pineal cyst on an otherwise normal brain MRI were included and compared to a control group of children with the same referral reasons but with a normal MRI and to a cohort of normal controls...
May 16, 2018: Sleep Medicine
Catherine J Libby, Sixue Zhang, Gloria A Benavides, Sarah E Scott, Yanjie Li, Matthew Redmann, Anh Nhat Tran, Arphaxad Otamias, Victor Darley-Usmar, Marek Napierala, Jianhua Zhang, Corinne Elizabeth Augelli-Szafran, Wei Zhang, Anita B Hjelmeland
Tumor heterogeneity has hampered the development of novel effective therapeutic options for aggressive cancers, including the deadly primary adult brain tumor glioblastoma (GBM). Intratumoral heterogeneity is partially attributed to the tumor initiating cell (TIC) subset that contains highly tumorigenic, stem-like cells. TICs display metabolic plasticity but can have a reliance on aerobic glycolysis. Elevated expression of GLUT1 and GLUT3 is present in many cancer types, with GLUT3 being preferentially expressed in brain TICs (BTICs) to increase survival in low nutrient tumor microenvironments, leading to tumor maintenance...
June 15, 2018: ACS Chemical Biology
Andrew Swayne, Linda Tjoa, Simon Broadley, Sasha Dionisio, David Gillis, Leslie Jacobson, Mark R Woodhall, Andrew McNabb, Daniel Schweitzer, Ben Tsang, Angela Vincent, Sarosh R Irani, Richard Wong, Patrick Waters, Stefan Blum
INTRODUCTION: Antibodies to glycine receptors (GlyR-Abs) were first defined in progressive encephalopathy with rigidity and myoclonus (PERM), but subsequently identified in other clinical presentations. We aimed to assess the clinical associations of all patients identified with GlyR-Abs in Queensland, Australia between April 2014 to May 2017, and compared these to cases reported in the literature. METHODS: A literature review identified the clinical features of all published GlyR-Ab positive cases through online databases...
June 15, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ning Zheng, Rui Li, Wenjuan Liu, Shuo Shao, Shan Jiang
OBJECTIVES: To determine the diagnostic value of combining conventional MRI, diffusion-weighted (DWI) and dynamic contrast enhanced MRI (DCE-MRI) in salivary gland tumors. METHODS: Forty-five patients with salivary gland tumors were evaluated with conventional MRI, DWI and DCE-MRI prior to surgery and confirmed by pathologic findings. The apparent diffusion coefficient (ADC) was calculated from DWI that was obtained with a factor of 0 and 1000 s/mm2 . A time-intensity curve (TIC) was obtained from DCE-MRI...
June 14, 2018: British Journal of Radiology
Leejin Kim, Sungmin Myoung
Background: The aim of this study was to explore the comorbidity of Attention-Deficit Hyperactivity Disorder (ADHD) for the Korean national health insurance data (NHID) by using association rule mining (ARM). Methods: We used data categorized mental disorder according to the international classification of disease, 10th revision (ICD-10) diagnosis system from NHID from 2011 to 2013 in youths aged 18 yr or younger. Overall, 211420 subjects, comorbid cases with ADHD were present in 105784...
April 2018: Iranian Journal of Public Health
Anat Lavie, Maya Ram, Shaul Lev, Yair Blecher, Uri Amikam, Yael Shulman, Tomer Avnon, Eran Weiner, Ariel Many
BACKGROUND: Preeclampsia is among the most common medical complications of pregnancy. The clinical utility of invasive hemodynamic monitoring in preeclampsia (e.g., Swan-Ganz catheter) is controversial. Thoracic impedance cardiography (TIC) and Doppler echocardiography are noninvasive techniques but they both have important limitations. NICaS™ (NI Medical, PetachTikva, Israel) is a noninvasive cardiac system for determining cardiac output (CO) that utilizes regional impedance cardiography (RIC) by noninvasively measuring the impedance signal in the periphery...
June 14, 2018: BMC Pregnancy and Childbirth
Khaoula Mkadmini Hammi, Majdi Hammami, Christophe Rihouey, Didier Le Cerf, Riadh Ksouri, Hatem Majdoub
Gas chromatography coupled to mass spectrometer (GC-MS) was used to identify and to quantify neutral sugars that constitute the water soluble polysaccharides from Zizyphus lotus fruit. The trimethylsilyl (TMS) method was successfully used for derivatization of the monosaccharides units of extracted polysaccharides that were released by hydrolysis method. Sugars were identified based on their retention times compared with those of standards and the NIST MS Spectral Library. All sugars were quantified in TIC (Total Ion Current) mode using calibration curves...
June 2018: Data in Brief
Mei-Yin Lee, Huei-Shyong Wang, Chen-Jung Chen, Mei-Hua Lee
AIMS AND OBJECTIVES: To explore and describe the experience of social adjustment of adolescents with Tourette syndrome in Taiwan. BACKGROUND: Although Tourette syndrome is a non-life-threatening disease, the inherent difficulties in controlling tics and comorbidities can cause long-term physical and psychological issues, as well as social maladjustment among adolescents. Good social adjustment can promote mental health among adolescents. Currently, it is not clear how adolescents with Tourette syndrome can self-adjust and maintain harmonious social interaction with others...
June 12, 2018: Journal of Clinical Nursing
Zhaojun Li, Yun Bai, Wanbin Li, Feng Gao, Yi Kuang, Lianfang Du, Xianghong Luo
Inflammatory activity plays a central role in the development of carotid rupture-vulnerable atherosclerotic plaques, which is one of the major contributors to acute ischemic stroke. Our objective was to characterize carotid intraplaque neovascularizations (INP) using contrast-enhanced ultrasound (CEUS) and evaluate plaque burden through exploring the relationship between INP and cell count of peripheral leukocytes. Sixty-two patients with large artery atherosclerosis (LAA) were enrolled in this study. CEUS was performed to characterize the carotid artery plaques...
June 11, 2018: Scientific Reports
Xiahan Sang, Yu Xie, Dundar E Yilmaz, Roghayyeh Lotfi, Mohamed Alhabeb, Alireza Ostadhossein, Babak Anasori, Weiwei Sun, Xufan Li, Kai Xiao, Paul R C Kent, Adri C T van Duin, Yury Gogotsi, Raymond R Unocic
Developing strategies for atomic-scale controlled synthesis of new two-dimensional (2D) functional materials will directly impact their applications. Here, using in situ aberration-corrected scanning transmission electron microscopy, we obtain direct insight into the homoepitaxial Frank-van der Merwe atomic layer growth mechanism of TiC single adlayers synthesized on surfaces of Ti3 C2 MXene substrates with the substrate being the source material. Activated by thermal exposure and electron-beam irradiation, hexagonal TiC single adlayers form on defunctionalized surfaces of Ti3 C2 MXene at temperatures above 500 °C, generating new 2D materials Ti4 C3 and Ti5 C4 ...
June 11, 2018: Nature Communications
Jiaojiao Gao, Jinpeng Song, Ming Lv
TiC0.7 N0.3 -HfC-WC-Ni-Mo cermet tool materials were fabricated by hot pressing technology at 1450 °C. The effects of WC (tungsten carbide) content on the microstructure and mechanical properties of TiC0.7 N0.3 -HfC-WC-Ni-Mo cermet tool materials were investigated. The results showed that the TiC0.7 N0.3 -HfC-WC-Ni-Mo cermets were mainly composed of TiC0.7 N0.3 , Ni, and (Ti, Hf, W, Mo)(C, N); there were three phases: a dark phase, a gray phase, and a light gray phase. The dark phase was the undissolved TiC0...
June 8, 2018: Materials
Frank Berenpas, Sven Schiemanck, Anita Beelen, Frans Nollet, Vivian Weerdesteyn, Alexander Geurts
BACKGROUND: Contralesional 'drop foot' after stroke is usually treated with an ankle-foot orthosis (AFO). However, AFOs may hamper ankle motion during stance. Peroneal functional electrical stimulation (FES) is an alternative treatment that provides active dorsiflexion and allows normal ankle motion. Despite this theoretical advantage of FES, the kinematic and kinetic differences between AFO and FES have been scarcely investigated. OBJECTIVE: To test whether walking with implanted FES leads to improvements in stance stability, propulsion, and swing initiation compared to AFO...
June 6, 2018: Restorative Neurology and Neuroscience
Chih-Wei Hsu, Liang-Jen Wang, Pao-Yen Lin
BACKGROUND: While previous studies have investigated the effect of repetitive transcranial magnetic stimulation (rTMS) in treating Tourette syndrome (TS), the results remain inconclusive. OBJECTIVE: We aim to systematically review the existing literature related to the efficacy of rTMS in TS and synthesize the results through meta-analysis. METHODS: We searched for PubMed, Embase, Cochrane Library, and databases without language restriction through January 1, 2018, and included randomized-controlled and open-label trials that assessed the treatment effect of rTMS for tic symptoms...
June 5, 2018: Brain Stimulation
Hong-Hua Li, Ling Shan, Bing Wang, Lin Du, Zhi-Da Xu, Fei-Yong Jia
The aim of this study is to evaluate serum 25-hydroxyvitamin D[25(OH)D] levels in children with tic disorders and to explore the relationship between serum 25(OH)D level and tic severity. Children (n = 179, 31 females, 148 males, mean age at diagnosis: 8.0 ± 2.7 years old, age ranged from 3 to 14.5 years old) who were diagnosed with a tic disorder were enrolled as case group, 189 healthy children were recruited as control group. Serum level of 25(OH)D of each child was measured by high performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS)...
May 31, 2018: Psychiatry Research
Victoria Pile, Sally Robinson, Marta Topor, Tammy Hedderly, Jennifer Y F Lau
Many individuals with Tourette syndrome and chronic tic disorders (TS/CTDs) report poor social functioning and comorbid social anxiety. Yet limited research has investigated the role of cognitive factors that highlight social threats in youth with TS/CTD, and whether these biases underlie tic severity and co-occurring social anxiety. This study examined whether selective attention to social threat is enhanced young people with TS/CTDs compared to healthy controls, and whether attention biases are associated with tic severity and social anxiety...
June 7, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
Christine A Conelea, Brianna Wellen, Douglas W Woods, Deanna J Greene, Kevin J Black, Matthew Specht, Michael B Himle, Han-Joo Lee, Matthew Capriotti
Tic suppression is the primary target of tic disorder treatment, but factors that influence voluntary tic inhibition are not well understood. Several studies using the Tic Suppression Task have demonstrated significant inter-individual variability in tic suppressibility but have individually been underpowered to address correlates of tic suppression. The present study explored patterns and clinical correlates of reward-enhanced tic suppression in youth with tic disorders using a large, pooled dataset. Individual-level data from nine studies using the Tic Suppression Task were pooled, yielding a sample of 99 youth with tic disorders...
2018: Frontiers in Psychiatry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"