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https://www.readbyqxmd.com/read/29043929/a-survey-based-study-identifies-common-but-unrecognized-symptoms-in-a-large-series-of-juvenile-huntington-s-disease
#1
Amelia D Moser, Eric Epping, Patricia Espe-Pfeifer, Erin Martin, Leah Zhorne, Katherine Mathews, Martha Nance, Denise Hudgell, Oliver Quarrell, Peg Nopoulos
AIM: The symptoms of Huntington's disease are well known, yet the symptoms of juvenile Huntington's disease (JHD) are less established due to its rarity. The study examined a cluster of symptoms considered to be common, but under-recognized in JHD: pain, itching, sleeping difficulties, psychosis and tics. MATERIALS & METHODS: A symptom survey was constructed using the online tool Qualtrics and dispersed to JHD caregivers through websites. RESULTS: A total of 33 surveys were completed...
October 18, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29042781/children-with-borderline-intellectual-functioning-and-autism-spectrum-disorder-developmental-trajectories-from-4-to-11-years-of-age
#2
Martina Barnevik Olsson, Anette Holm, Joakim Westerlund, Åsa Lundholm Hedvall, Christopher Gillberg, Elisabeth Fernell
BACKGROUND: Studies on autism have tended to focus either on those with intellectual disability (ie, those with intellectual quotient [IQ] under 70) or on the group that is referred to as "high-functioning", that is, those with borderline, average or above average IQ. The literature on cognition and daily functioning in autism spectrum disorder combined specifically with borderline intellectual functioning (IQ 70-84) is limited. METHODS: From a representative group of 208 preschool children diagnosed with autism spectrum disorder, those 50 children in the group with borderline intellectual functioning at ages 4...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29042492/validation-of-the-telephone-interview-of-cognitive-status-and-telephone-montreal-cognitive-assessment-against-detailed-cognitive-testing-and-clinical-diagnosis-of-mild-cognitive-impairment-after-stroke
#3
Vera Zietemann, Anna Kopczak, Claudia Müller, Frank Arne Wollenweber, Martin Dichgans
BACKGROUND AND PURPOSE: Assessment of cognitive status poststroke is recommended by guidelines but follow-up can often not be done in person. The Telephone Interview of Cognitive Status (TICS) and the Telephone Montreal Cognitive Assessment (T-MoCA) are considered useful screening instruments. Yet, evidence to define optimal cut-offs for mild cognitive impairment (MCI) after stroke is limited. METHODS: We studied 105 patients enrolled in the prospective DEDEMAS study (Determinants of Dementia After Stroke; NCT01334749)...
October 17, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29038479/probing-ligand-recognition-of-the-opioid-pan-antagonist-at-076-at-nociceptin-kappa-mu-and-delta-opioid-receptors-through-structure-activity-relationships
#4
V Blair Journigan, Willma E Polgar, Edward W Tuan, James Lu, Pankaj R Daga, Nurulain T Zaveri
Few opioid ligands binding to the three classic opioid receptor subtypes, mu, kappa and delta, have high affinity at the fourth opioid receptor, the nociceptin/orphanin FQ receptor (NOP). We recently reported the discovery of AT-076 (1), (R)-7-hydroxy-N-((S)-1-(4-(3-hydroxyphenyl)piperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, a pan antagonist with nanomolar affinity for all four subtypes. Since AT-076 binds with high affinity at all four subtypes, we conducted a structure-activity relationship (SAR) study to probe ligand recognition features important for pan opioid receptor activity, using chemical modifications of key pharmacophoric groups...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029679/investigating-habituation-to-premonitory-urges-in-behavior-therapy-for-tic-disorders
#5
David C Houghton, Matthew R Capriotti, Lawrence D Scahill, Sabine Wilhelm, Alan L Peterson, John T Walkup, John Piacentini, Douglas W Woods
Behavior therapy is effective for Persistent Tic Disorders (PTDs), but behavioral processes facilitating tic reduction are not well understood. One process, habituation, is thought to create tic reduction through decreases in premonitory urge severity. The current study tested whether premonitory urges decreased in youth with PTDs (N = 126) and adults with PTDs (N = 122) who participated in parallel randomized clinical trials comparing behavior therapy to psychoeducation and supportive therapy (PST). Trends in premonitory urges, tic severity, and treatment outcome were analyzed according to the predictions of a habituation model, whereby urge severity would be expected to decrease in those who responded to behavior therapy...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29027949/the-flexural-strength-and-fracture-toughness-of-tc4-based-laminated-composites-reinforced-with-ti-aluminide-and-carbide
#6
Yanhan Fei, Taotao Ai, Qunfei Niu, Wenhu Li, Xinqiang Yuan, Ran Jing, Hongfeng Dong
TiC-Ti-Al mixed powders and TC4 titanium alloy foils were overlapped layer-by-layer in the graphite die. The TC4-based laminated composite sheets reinforced by Ti aluminide and carbide were successfully fabricated via spark plasma sintering (SPS) at 1100 °C with a well-bonded interface. The composite layers were mainly composed of TiAl, Ti₃Al, Ti₂AlC, and Ti₃AlC₂ phases. The carbides particles distributed in the matrix played an important role in the deflection of cracks and the passivation of microcracks...
October 13, 2017: Materials
https://www.readbyqxmd.com/read/29017141/premonitory-urges-and-tics-in-tourette-syndrome-computational-mechanisms-and-neural-correlates
#7
REVIEW
Vasco A Conceição, Ângelo Dias, Ana C Farinha, Tiago V Maia
Tourette syndrome is characterized by open motor behaviors - tics - but another crucial aspect of the disorder is the presence of premonitory urges: uncomfortable sensations that typically precede tics and are temporarily alleviated by tics. We review the evidence implicating the somatosensory cortices and the insula in premonitory urges and the motor cortico-basal ganglia-thalamo-cortical loop in tics. We consider how these regions interact during tic execution, suggesting that the insula plays an important role as a nexus linking the sensory and emotional character of premonitory urges with their translation into tics...
October 7, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29016153/the-implementation-and-effect-of-trauma-informed-care-within-residential-youth-services-in-rural-canada-a-mixed-methods-case-study
#8
Courtney N Baker, Steven M Brown, Patricia Wilcox, Jorge M Verlenden, Corey L Black, Billie-Jo E Grant
OBJECTIVE: The prevalence and associated risks of trauma have led youth-serving institutions to adopt trauma-informed care (TIC). A limited research base has linked TIC with improved outcomes. Associations between TIC and vicarious traumatization (VT) are even less commonly studied. The purpose of this case study is to evaluate the implementation and effect of TIC within 1 residential youth services division in rural Canada using the curriculum-based Risking Connection (RC; Saakvitne et al...
October 9, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28993054/near-infrared-spectroscopy-nirs-for-a-real-time-monitoring-of-the-biogas-process
#9
Andrea Stockl, Fabian Lichti
In this research project Near-infrared spectroscopy (NIRS) was applied to monitor the content of specific process parameters in anaerobic digestion. A laboratory scaled biogas digester was constantly fed every four hours with maize- and grass silage to keep a base load with an organic loading rate (OLR) of 2.5 kg oDM/m(3) ∗ d. Daily impact loads with shredded wheat up to an OLR of 8 kg oDM/m(3) ∗ d were added in order to generate peaks at the parameters tested. The developed calibration models are capable to show changes in process parameters like volatile fatty acids (VFA), propionic acid, total inorganic carbon (TIC) and the ratio of the volatile fatty acids to the carbonate buffer (VFA/TIC)...
September 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28992712/-biologic-aspects-of-adhd-and-conduct-disorders-in-childhood-and-adolescence-selected-preventive-aspects
#10
Ivo Paclt, Nikol Přibilová
Next to environmental factors and problems with interpersonal interaction in family represent developmental findings the basic of understanding these disorders (ADHD, conduct disorders, obsessive-compulsive disorders, tic disorders etc.). Knowledges of neurodevelopment disorders represent new possibilities of prevention and treatment.
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28991227/essential-role-of-mettl3-mediated-m-6-a-modification-in-glioma-stem-like-cells-maintenance-and-radioresistance
#11
A Visvanathan, V Patil, A Arora, A S Hegde, A Arivazhagan, V Santosh, K Somasundaram
Despite advances in biology and therapeutic modalities, existence of highly tumorigenic glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine (m(6)A), one of the abundant mRNA modifications catalyzed by methyltransferase-like 3 and 14 (METTL3/14), influences various events in RNA metabolism. Here, we report the crucial role of METTL3-mediated m(6)A modification in GSC (neurosphere) maintenance and dedifferentiation of glioma cells. METTL3 expression is elevated in GSC and attenuated during differentiation...
October 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28989137/characteristic-of-malocclusion-among-saudi-special-need-group-children
#12
Thamer Alkhadra
INTRODUCTION: The present study analyzed the characteristics of malocclusions, occlusal traits among Special Health care Needs (SHCN) children with Down syndrome (DS) and autism disorder (AD) in Riyadh City, Kingdom of Saudi Arabia. MATERIALS AND METHODS: A total of 100 DS and 100 AD children from five rehabilitation centers in and around Riyadh, Kingdom of Saudi Arabia, were included in the study. Any children with history of ongoing medical treatment, extraction, or orthodontic treatment were excluded from the study...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28989131/comparison-of-hypersensitivity-in-metal-ceramic-crowns-cemented-with-zinc-phosphate-and-self-adhesive-resin-a-prospective-study
#13
Thatapudi Shankar, Mirna Garhnayak, Lokanath Garhnayak, Angurbala Dhal, Aswini K Kar
BACKGROUND: Luting agents used to fix artificial prostheses, such as fixed partial denture (FPD) to tooth are basically viscous in nature and show chemical reaction for fixation. Postcementation hypersensitivity is a frequent complaint of patients. The present study was conducted to compare postcementation hypersensitivity with zinc phosphate and self-adhesive resin in complete coverage crown. MATERIALS AND METHODS: This study included 30 patients in which 60 porcelein fused to metal crowns was placed...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28981223/-child-behavior-disorder-clinical-reasoning-in-general-practice
#14
N Kacenelenbogen
CONTEXT: in Belgium 70 % of the children aged 0 - 14 years have at least one annual contact with their family doctor, while for the same period, only 6 - 12 % of them will see a neuropaediatrician and/or a child psychiatrist, despite the fact that a diagnostic of Externalizing behavior before the age of 6 to 7 years, such as various ways of aggressiveness, of anger or of stealing will very often alert the family, the staff of creches or nursery as well as the teachers. Other children are showing signs of Internalizing behavior, very often together with depression or other forms of anxiety...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28981184/soluble-fibrin-going-for-six
#15
Samantha J Montague
Coagulopathy commonly arises in patients following traumatic injury and is a major clinical burden [1]. Trauma-induced coagulopathy (TIC) is a multi-factorial condition associated with increased thrombin generation, coagulation factor consumption and activation of fibrinolytic pathways, leading to increased generation of plasmin, fibrin and fibrin degradation products, including D-dimers [1-3]. TIC also affects platelet function, where trauma patients can present with a hypofunctional platelet phenotype even with normal platelet count, which predicts mortality and poor patient outcome [4-7]...
October 5, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28977908/cardiotoxicity-of-trastuzumab-in-patients-with-her2-positive-gastric-cancer
#16
Ji Soo Park, Jong-Chan Youn, Chi Young Shim, Geu-Ru Hong, Choong-Kun Lee, Jee Hyung Kim, Hyung Soon Park, Su Jin Heo, Seung Hoon Beom, Hyo Song Kim, Sun Young Rha, Hyun Cheol Chung, Seok-Min Kang, Minkyu Jung
Trastuzumab-induced cardiotoxicity (TIC) is the primary adverse event that limits the use of trastuzumab in HER2-positive breast cancer patients. However, the incidence and risk factors of TIC in HER2-positive gastric cancer are not known. Therefore, we evaluated the incidence and predictive factors of TIC in gastric cancer patients treated with trastuzumab in clinical practice. We reviewed cardiac dysfunction in HER2-positive gastric cancer patients between December 2005 and April 2015 in a prospectively-collected database that included prospective clinical trials at Yonsei Cancer Center, Republic of Korea...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28970361/nfkb-mediated-invasiveness-in-cd133-pancreatic-tics-is-regulated-by-autocrine-and-paracrine-activation-of-il-1-signaling
#17
Alice Nomura, Vineet K Gupta, Patricia Dauer, Nikita S Sharma, Vikas Dudeja, Nipun Merchant, Ashok Saluja, Sulagna Banerjee
Tumor-initiating cells (TICs) have been implicated in pancreatic tumor initiation, progression, and metastasis. Among different markers that define this cell population within the tumor, the CD133+ cancer stem cell (CSC) population has reliably been described in these processes. CD133 expression has also been shown to functionally promote metastasis through NF-κB activation in this population but, the mechanism is unclear. In the current study, overexpression of CD133 increased expression and secretion of IL-1β (IL1B), which activates an autocrine signaling loop that upregulates NF-κB signaling, epithelial-mesenchymal transition (EMT), and cellular invasion...
September 28, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28967919/chromosome-1q21-3-amplification-is-a-trackable-biomarker-and-actionable-target-for-breast-cancer-recurrence
#18
Jian Yuan Goh, Min Feng, Wenyu Wang, Gokce Oguz, Siti Maryam J M Yatim, Puay Leng Lee, Yi Bao, Tse Hui Lim, Panpan Wang, Wai Leong Tam, Annette R Kodahl, Maria B Lyng, Suman Sarma, Selena Y Lin, Alexander Lezhava, Yoon Sim Yap, Alvin S T Lim, Dave S B Hoon, Henrik J Ditzel, Soo Chin Lee, Ern Yu Tan, Qiang Yu
Tumor recurrence remains the main reason for breast cancer-associated mortality, and there are unmet clinical demands for the discovery of new biomarkers and development of treatment solutions to benefit patients with breast cancer at high risk of recurrence. Here we report the identification of chromosomal copy-number amplification at 1q21.3 that is enriched in subpopulations of breast cancer cells bearing characteristics of tumor-initiating cells (TICs) and that strongly associates with breast cancer recurrence...
September 25, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28967016/first-principles-investigation-of-h2s-adsorption-and-dissociation-on-titanium-carbide-surfaces
#19
Shiyan Wang, Xilin Zhang, Yanxing Zhang, Jianjun Mao, Zongxian Yang
The adsorption and dissociation reactions of H2S on TiC(001) are investigated using first-principles density functional theory calculations. The geometric and electronic structures of the adsorbed S-based species (including H2S, SH and S) on TiC(001) are analyzed in detail. It is found that the H2S is bound weakly, while SH and atomic S are bound strongly on the TiC(001) surface. The transition state calculations show that the formation of SH from H2S (H2S → SH + H) is very easy, while the presence of a co-adsorbed H will inhibit the further dissociation of SH (SH + H → S + H + H)...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28966546/tic-treatment-goes-tech-a-review-of-tichelper-com
#20
Christine A Conelea, Brianna C M Wellen
TicHelper.com ("TicHelper") is an interactive online treatment program for youth with chronic tic disorders (CTDs) or Tourette Syndrome (TS) and their parents. It is based on Comprehensive Behavioral Intervention for Tics (CBIT), an individual, outpatient therapy protocol shown to effectively reduce tics in randomized controlled trials. The TicHelper website offers a user-friendly dashboard that is effective in making it easy to navigate through different treatment modules. Modules parallel core CBIT procedures and consist of interactive exercises, informational videos, and self-report ratings...
August 2017: Cognitive and Behavioral Practice
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