keyword
MENU ▼
Read by QxMD icon Read
search

Tics

keyword
https://www.readbyqxmd.com/read/28734459/the-roles-of-phasic-and-tonic-dopamine-in-tic%C3%A2-learning-and-expression
#1
REVIEW
Tiago V Maia, Vasco A Conceição
Tourette syndrome (TS) prominently involves dopaminergic disturbances, but the precise nature of those disturbances has remained elusive. A substantial body of empirical work and recent computational models have characterized the specific roles of phasic and tonic dopamine (DA) in action learning and selection, respectively. Using insights from this work and models, we suggest that TS involves increases in both phasic and tonic DA, which produce increased propensities for tic learning and expression, respectively...
June 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28729778/effect-of-contrast-enhanced-ultrasound-on-differential-diagnosis-of-intrahepatic-cholangiocarcinoma-and-arterial-phase-enhanced-hepatic-inflammatory-lesions
#2
Shanshan Yin, Qiuli Cui, Kun Yan, Wei Yang, Wei Wu, Liping Bao, Minhua Chen
OBJECTIVE: To investigate differential diagnosis between intrahepatic cholangiocarcinoma (ICC) and arterial phase enhanced hepatic inflammatory lesions in patients without liver cirrhosis using contrast-enhanced ultrasound (CEUS). METHODS: ICC and hepatic inflammatory lesions cases with CEUS and pathological diagnosis between Sep 2013 and Oct 2016 were investigated retrospectively. Imaging features of conventional ultrasound and CEUS were analyzed. The parameters of time intensity curve (TIC), including the arrival time, peak intensity (PI) in the lesions, the starting time for washout, and the intensity difference at 3 min (ΔI3) after contrast agent infection between the lesion and the liver parenchyma, were compared between ICC and hepatic inflammatory lesions...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28723227/extended-release-guanfacine-does-not-show-a-large-effect-on-tic-severity-in-children-with-chronic-tic-disorders
#3
Tanya K Murphy, Thomas V Fernandez, Barbara J Coffey, Omar Rahman, Allison Gavaletz, Camille E Hanks, Caitlin S Tillberg, Laura Ibanez Gomez, Denis G Sukhodolsky, Lily Katsovich, Lawrence Scahill
OBJECTIVE: To evaluate the tolerability, safety, and preliminary efficacy of extended-release guanfacine in children with chronic tic disorders, including Tourette's disorder (collectively referred to as CTD). METHODS: This was a multisite, 8-week, randomized, double-blind, placebo-controlled trial. The primary outcome measure was the Yale Global Tic Severity Scale (YGTSS) total score. Key secondary outcomes included the Improvement item of Clinical Global Impressions-Improvement (CGI-I) scale and the Tic Symptom Self-report (TSSR)...
July 19, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28722101/-gilles-de-la-tourette-syndrome-symptoms-causes-and-therapy
#4
Ewgeni Jakubovski, Kirsten R Müller-Vahl
Gilles de la Tourette syndrome is a chronic neuropsychiatric movement disease with combined motor tics and at least one vocal tic for a minimum period of 1 year. It typically begins in the childhood (under 18 years of age).Most of the patients with Tourette syndrome have comorbidities, which often impair their quality of life more than the tics themselves.There are reported abnormalities in the cortico-striato-thalamo-cortical regions as well as in the neurotransmission of dopamine and other neurotransmission systems...
June 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28716772/chewing-induced-facial-dystonia-a-rare-presentation-of-task-specific-dystonia
#5
Chandramohan Sharma, Banshi Lal Kumawat, Ankur Garg, Kaushik Kumar Rana
This case is an addition to scarce literature available for a rare condition, chewing-induced task-specific dystonia. The patient was a 63-year-old woman who presented with a 4-year history of progressive difficulty in eating food only during chewing associated with abnormal facial grimaces without any difficulty in drinking, swallowing, speaking or singing. Examination revealed dystonia of facial muscles every time she chewed but absent during drinking and speaking. As movements were consistent and reproducible with the specific task, other differential diagnosis like motor tics, psychogenic disorder, tardive dystonia and parkinsonism syndrome were excluded leading to a diagnosis of task-specific facial dystonia triggered by chewing...
July 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28712880/the-role-of-oxidative-stress-in-antipsychotics-induced-ovarian-toxicity
#6
Ekramy Elmorsy, Ayat Al-Ghafari, Amal Misbah Aggour, Raheela Khan, Saad Amer
This study tested the hypothesis that oxidative stress could be an underlying mechanism for APs-induced ovarian cytotoxicity and reproductive dysfunction. Rat ovarian theca interstitial cells (TICs) were isolated and treated with four APs [chlorpromazine (CPZ), haloperidol (HAL), risperidone (RIS) and clozapine (CLZ)]. MTT assay was used to test the effects of these antipsychotics on TICs viability and to estimate their 50% inhibitory concentrations (IC50s). The effects of APs (IC50s and 1μM concentrations) on the activities of caspases-3, -8 and -9, reactive oxygen species (ROS) production, total intracellular glutathione and lipid peroxidation (LPO) in TICs were assessed...
July 13, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28708864/abnormal-lateralization-of-fine-motor-actions-in-tourette-syndrome-persists-into-adulthood
#7
D Martino, C Delorme, E Pelosin, A Hartmann, Y Worbe, L Avanzino
Youth with Tourette syndrome (TS) exhibit, compared to healthy, abnormal ability to lateralize digital sequential tasks. It is unknown whether this trait is related to inter-hemispheric connections, and whether it is preserved or lost in patients with TS persisting through adult life. We studied 13 adult TS patients and 15 age-matched healthy volunteers. All participants undertook: 1) a finger opposition task, performed with the right hand (RH) only or with both hands, using a sensor-engineered glove in synchrony with a metronome at 2 Hz; we calculated a lateralization index [(single RH-bimanual RH)/single RH X 100) for percentage of correct movements (%CORR); 2) MRI-based diffusion tensor imaging and probabilistic tractography of inter-hemispheric corpus callosum (CC) connections between supplementary motor areas (SMA) and primary motor cortices (M1)...
2017: PloS One
https://www.readbyqxmd.com/read/28700343/cardiotoxicity-of-trastuzumab-in-patients-with-her2-positive-gastric-cancer
#8
Ji Soo Park, Jong-Chan Youn, Chi Young Shim, Geu-Ru Hong, Choong-Kun Lee, Jee Hyung Kim, Hyung Soon Park, Su Jin Heo, Seung Hoon Beom, Hyo Song Kim, Sun Young Rha, Hyun Cheol Chung, Seok-Min Kang, Minkyu Jung
Trastuzumab-induced cardiotoxicity (TIC) is the primary adverse event that limits the use of trastuzumab in HER2-positive breast cancer patients. However, the incidence and risk factors of TIC in HER2-positive gastric cancer are not known. Therefore, we evaluated the incidence and predictive factors of TIC in gastric cancer patients treated with trastuzumab in clinical practice. We reviewed cardiac dysfunction in HER2-positive gastric cancer patients between December 2005 and April 2015 in a prospectively-collected database that included prospective clinical trials at Yonsei Cancer Center, Republic of Korea...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28697832/-efficacy-of-clonidine-transdermal-patch-in-treatment-of-moderate-to-severe-tic-disorders-in-children
#9
Jing-Min Guo, Xiao-Xi Shi, Shi-Wei Yang, Qin-Fang Qian, Yan Huang, Yan-Qin Xie, Ping Ou
OBJECTIVE: To investigate the difference in the efficacy between clonidine transdermal patch and haloperidol tablets in the treatment of moderate to severe tic disorders in children. METHODS: A total of 134 children with moderate to severe tic disorders were randomly divided into clonidine group (n=70) and haloperidol group (n=64). The clonidine and haloperidol groups were treated with clonidine transdermal patch and haloperidol tablets respectively, and the treatment lasted for 8 weeks in both groups...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28697023/clot-dynamics-and-mortality-the-ma-r-ratio
#10
Stephanie A Savage, Ben L Zarzaur, Timothy H Pohlman, Brian L Brewer, Louis J Magnotti, Martin A Croce, Garrett H Lim, Ali C Martin
INTRODUCTION: The coagulopathy of trauma, illustrated by a short R-time, is common and well understood. The physiology behind this may be early thrombin burst with rapid clot formation. Rapid consumption of fibrinogen, however, may result in weak clot and substrate depletion, resulting in low MA. While these characteristics are interesting, utilizing TEG to identify those at risk for subsequent bleeding diathesis, especially in those who do not demonstrate early signs of physiologic derangement, is challenging...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28694557/overexpression-of-mir-24-is-involved-in-the-formation-of-hypocoagulation-state-after-severe-trauma-by-inhibiting-the-synthesis-of-coagulation-factor-x
#11
Lu-Jia Chen, Lian Yang, Xing Cheng, Yin-Kai Xue, Li-Bo Chen
BACKGROUND: Dysregulation of microRNAs may contribute to the progression of trauma-induced coagulopathy (TIC). We aimed to explore the biological function that miRNA-24-3p (miR-24) might have in coagulation factor deficiency after major trauma and TIC. METHODS: 15 healthy volunteers and 36 severe trauma patients (Injury Severity Score ≥ 16 were enrolled. TIC was determined as the initial international normalized ratio >1.5. The miR-24 expression and concentrations of factor X (FX) and factor XII in plasma were measured...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694195/hemoglobins-emerging-roles-in-mental-disorders-metabolical-genetical-and-immunological-aspects
#12
REVIEW
Meric A Altinoz, Bahri Ince
Hemoglobin (Hb) expression in the central nervous system is recently shown. Cooccurences of mental disorders (mainly bipolar disorder (BD) and tic disorders) with β- or α-thalassemia trait or erythrocytosis were witnessed, which may be due to peripheral or central hypoxia/hyperoxia or haplotypal gene interactions. β-Globin genes reside at 11p15.5 close to tyrosine hydroxylase, dopamine receptor DRD4 and Brain Derived Neurotrophic Factor, which involve in psychiatric diseases. α-Globin genes reside at 16p13...
July 8, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28693150/dhfr-and-mdr1-upregulation-is-associated-with-chemoresistance-in-osteosarcoma-stem-like-cells
#13
Yu-Hsien Lee, Hui-Wen Yang, Li-Chiu Yang, Ming-Yi Lu, Lo-Lin Tsai, Shun-Fa Yang, Yu-Feng Huang, Ming-Yung Chou, Cheng-Chia Yu, Fang-Wei Hu
Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS-TICs) were isolated and enriched from the osteosarcoma U2OS and MG-63 cell lines using sphere formation assays and serum-depleted media. These enriched OS-TICs showed the expression of several typical cancer stemness markers, including octamer-binding transcription factor 4, Nanog homeobox, cluster of differentiation (CD)117, Nestin and CD133, and the expression of ATP binding cassette subfamily G member 2, multidrug resistance protein 1 (MDR1) and dihydrofolate reductase (DHFR)...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691501/factors-contributing-to-hospital-stay-and-total-inpatient-charges-in-total-ankle-arthroplasty-review-of-the-national-inpatient-sample
#14
Jason L Codding, Benjamin M Zmistowski, Daniel E Davis, Mitchell G Maltenfort, David I Pedowitz
Total ankle arthroplasty (TAA) is commonly performed for end-stage ankle osteoarthritis. Given rising costs and declining reimbursements, identifying variables increasing length of stay (LOS) and total inpatient charges (TICs) of TAA is necessary for providing cost-effective care. The National Inpatient Sample (NIS) database was reviewed between 1993 and 2010, identifying LOS and TIC for TAA. Using a multivariate analysis, patient comorbidities, demographics, payment, and hospital details were evaluated. Median LOS decreased from 5 to 2 days, whereas median TICs increased from $21 382...
July 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28691324/diagnostic-value-of-contrast-enhanced-ultrasonography-and-time-intensity-curve-in-differential-diagnosis-of-cervical-metastatic-and-tuberculous-lymph-nodes
#15
Qiu-Li Cui, Shan-Shan Yin, Zhi-Hui Fan, Wei Yang, Song Wang, Kun Yan
OBJECTIVES: To evaluate the diagnostic value of contrast-enhanced ultrasonography (CEUS) in the differential diagnosis of tuberculous and metastatic lymph nodes. METHODS: Nineteen cervical tuberculous lymph nodes and 43 cervical metastatic lymph nodes were investigated. The CEUS perfusion patterns and parameters of time-intensity curve (TIC) were analyzed. Diagnostic accuracy and consistency of two physicians were compared before and after CEUS and TIC analysis...
July 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28690116/evaluating-pathologic-response-of-breast-cancer-to-neoadjuvant-chemotherapy-with-computer-extracted-features-from-contrast-enhanced-ultrasound-videos
#16
Qi Zhang, Congcong Yuan, Wei Dai, Lei Tang, Jun Shi, Zuoyong Li, Man Chen
PURPOSE: To extract quantitative perfusion and texture features with computer assistance from contrast-enhanced ultrasound (CEUS) videos of breast cancer before and after neoadjuvant chemotherapy (NAC), and to evaluate pathologic response to NAC with these features. METHODS: Forty-two CEUS videos with 140,484 images were acquired from 21 breast cancer patients pre- and post-NAC. Time-intensity curve (TIC) features were calculated including the difference between area under TIC within a tumor and that within a computer-detected reference region (AUT_T-R)...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28688234/separation-and-characterization-of-unknown-impurities-in-cefonicid-sodium-by-trap-free-two-dimensional-liquid-chromatography-combined-with-ion-trap-time-of-flight-mass-spectrometry
#17
Jian Wang, Yu Xu, Yunfeng Zhang, Hong Wang, Weihui Zhong
RATIONALE: Seven unknown antibiotic impurities in cefonicid sodium were separated and characterized by a trap-free two-dimensional liquid chromatography coupled to high resolution ion trap/time-of-flight mass spectrometry s2D LC-IT-TOF MS) with positive and negative modes of electrospray ionization method. Trap-free two-dimensional liquid chromatography and online demineralization technique made it possible to characterize cefonicid sodium in the condition of the official standard, and the TIC chromatogram of LC-MS was in conformity with the LC chromatogram of the official analytical method in the peak sequence of impurities...
July 8, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28687006/glycolytic-reprogramming-through-pck2-regulates-tumor-initiation-of-prostate-cancer-cells
#18
Jiangsha Zhao, Jieran Li, Teresa W M Fan, Steven X Hou
Tumor-initiating cells (TICs) play important roles in tumor progression and metastasis. Identifying the factors regulating TICs may open new avenues in cancer therapy. Here, we show that TIC-enriched prostate cancer cell clones use more glucose and secrete more lactate than TIC-low clones. We determined that elevated levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. Information from prostate cancer patient databases revealed that higher PCK2 levels correlated with more aggressive tumors and lower survival rates...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28686554/geographic-differences-in-persistent-organic-pollutant-levels-of-yellowfin-tuna
#19
Sascha C T Nicklisch, Lindsay T Bonito, Stuart Sandin, Amro Hamdoun
BACKGROUND: Fish are a source of persistent organic pollutants (POPs) in the human diet. Although species, trophic level, and means of production are typically considered in predicting fish pollutant load, and thus recommendations of consumption, capture location is usually not accounted for. OBJECTIVES: Yellowfin tuna (Thunnus albacares) are harvested from across the world's oceans and are widely consumed. Here, we determined geographic variation in the overall mass, concentration, and composition of POPs in yellowfin and examined the differences in levels of several POP congeners of potential relevance to human health...
June 26, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28686474/randomized-double-blind-placebo-controlled-trial-demonstrates-the-efficacy-and-safety-of-oral-aripiprazole-for-the-treatment-of-tourette-s-disorder-in-children-and-adolescents
#20
Floyd Sallee, Eva Kohegyi, Joan Zhao, Robert McQuade, Kevin Cox, Raymond Sanchez, Alet van Beek, Margaretta Nyilas, William Carson, Roger Kurlan
OBJECTIVES: Aripiprazole modulates dopaminergic and serotonergic pathways that may play a role in the pathogenesis of Tourette's disorder (TD). This trial evaluated the efficacy and safety of oral aripiprazole in the suppression of tics in children and adolescents with TD. METHODS: This phase 3, randomized, double-blind, placebo-controlled trial (ClinicalTrials.gov , NCT01727700) recruited patients who were 7-17 years old with a diagnosis of TD from hospitals, private practices, and research clinics at 76 sites in the United States, Canada, Hungary, and Italy...
July 7, 2017: Journal of Child and Adolescent Psychopharmacology
keyword
keyword
17337
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"