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https://www.readbyqxmd.com/read/28333964/optimizing-ultrasound-molecular-imaging-of-secreted-frizzled-related-protein-2-expression-in-angiosarcoma
#1
James K Tsuruta, Nicholas P Schaub, Juan D Rojas, Jason Streeter, Nancy Klauber-DeMore, Paul Dayton
Secreted frizzled related protein 2 (SFRP2) is a tumor endothelial marker expressed in angiosarcoma. Previously, we showed ultrasound molecular imaging with SFRP2-targeted contrast increased average video pixel intensity (VI) of angiosarcoma vessels by 2.2 ± 0.6 VI versus streptavidin contrast. We hypothesized that redesigning our contrast agents would increase imaging performance. Improved molecular imaging reagents were created by combining NeutrAvidin™-functionalized microbubbles with biotinylated SFRP2 or IgY control antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/28331502/a-qualitative-exploration-of-the-experiences-of-children-and-adolescents-with-tourette-syndrome
#2
Kim R Edwards, Sandra Mendlowitz, Elana Jackson, Claire Champigny, Matt Specht, Paul Arnold, Daniel Gorman, Gina Dimitropoulos
OBJECTIVE: The purpose of this qualitative study was to explore the experiences of youth with Tourette Syndrome (TS). METHOD: Thirteen participants with TS were recruited from a large tertiary care hospital to complete semi-structured interviews and two questionnaires pertaining to demographic information and tic severity. Thematic analysis was utilized to systematically analyze the data. RESULTS: Three main themes were identified: 1) beliefs about TS; 2) TS related distress and impairment; and, 3) coping with TS...
2017: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28329579/habit-tic-nail-deformity-a-rare-presentation-in-an-8-year-old-boy
#3
S El-Heis, Al Abadie
Habit tic nail deformity is a nail dystrophy resulting from habitual, repetitive trauma to the nail. It is usually acquired in adulthood, however, we report a case of habit tic nail deformity in an 8 year old boy. The diagnosis was made clinically with further history revealing that the boy repeatedly rubbed his thumbnails and pushed the cuticles. Emollient cream (Balneum®) was recommended twice daily and both the patient and his mother were educated on the behavioral nature of this condition. There was marked improvement at 6 months of treatment and further improvement at 12 months...
November 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28322891/effect-of-antipsychotics-on-mitochondrial-bioenergetics-of-rat-ovarian-theca-cells
#4
Ekramy Elmorsy, Ayat Al-Ghafari, Amal Misbah Aggour, Soaad Mohamed Mosad, Raheela Khan, Saad Amer
BACKGROUND: Antipsychotics (APs) are widely prescribed drugs, which are well known to cause reproductive adverse effects through mechanisms yet to be determined. The purpose of this study was to investigate the effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells as a possible mechanism of reproductive toxicity. METHODS: Isolated rat's theca interstitial cells (TICs) were treated with two typical (chlorpromazine [CPZ] and haloperidol [HAL]) and two atypical APs (risperidone [RIS] and clozapine [CLZ])...
March 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28319068/iron-addiction-a-novel-therapeutic-target-in-ovarian-cancer
#5
D Basuli, L Tesfay, Z Deng, B Paul, Y Yamamoto, G Ning, W Xian, F McKeon, M Lynch, C P Crum, P Hegde, M Brewer, X Wang, L D Miller, N Dyment, F M Torti, S V Torti
Ovarian cancer is a lethal malignancy that has not seen a major therapeutic advance in over 30 years. We demonstrate that ovarian cancer exhibits a targetable alteration in iron metabolism. Ferroportin (FPN), the iron efflux pump, is decreased, and transferrin receptor (TFR1), the iron importer, is increased in tumor tissue from patients with high grade but not low grade serous ovarian cancer. A similar profile of decreased FPN and increased TFR1 is observed in a genetic model of ovarian cancer tumor-initiating cells (TICs)...
March 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28300946/kraepelin-s-views-on-obsessive-neurosis-a-comparison-with-dsm-5-criteria-for-obsessive-compulsive-disorder
#6
Holger Steinberg, Dirk Carius, Leonardo F Fontenelle
Emil Kraepelin (1856-1926) is considered one of the founders of modern psychiatric nosology. However, his conceptualization of obsessive-compulsive phenomena is relatively understudied. In this article, we compare and contrast excerpts from the eighth edition (1909-1915) of Kraepelin's Textbook of Clinical Psychiatry focusing on what Kraepelin called "obsessive neurosis" and related "original pathological conditions" with the current DSM-5 criteria for obsessive-compulsive disorder (OCD). Consistently with DSM-5 OCD, Kraepelin described obsessive neurosis as characterized by obsessive ideas, compulsive acts, or both together...
March 13, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28300008/prevalence-of-suicide-attempt-and-clinical-characteristics-of-suicide-attempters-with-obsessive-compulsive-disorder-a-report-from-the-international-college-of-obsessive-compulsive-spectrum-disorders-icocs
#7
Bernardo Dell'Osso, Beatrice Benatti, Chiara Arici, Carlotta Palazzo, A Carlo Altamura, Eric Hollander, Naomi Fineberg, Dan J Stein, Humberto Nicolini, Nuria Lanzagorta, Donatella Marazziti, Stefano Pallanti, Michael van Ameringen, Christine Lochner, Oguz Karamustafalioglu, Luchezar Hranov, Martijn Figee, Lynne Drummond, Carolyn I Rodriguez, John Grant, Damiaan Denys, Jose M Menchon, Joseph Zohar
OBJECTIVE: Obsessive-compulsive disorder (OCD) is associated with variable risk of suicide and prevalence of suicide attempt (SA). The present study aimed to assess the prevalence of SA and associated sociodemographic and clinical features in a large international sample of OCD patients. METHODS: A total of 425 OCD outpatients, recruited through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network, were assessed and categorized in groups with or without a history of SA, and their sociodemographic and clinical features compared through Pearson's chi-squared and t tests...
March 16, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28299943/the-value-of-combining-conventional-diffusion-weighted-and-dynamic-contrast-enhanced-mr-imaging-for-the-diagnosis-of-parotid-gland-tumors
#8
Xiaofeng Tao, Gongxin Yang, Pingzhong Wang, Yingwei Wu, Wenjing Zhu, Huimin Shi, Xin Gong, Weiqing Gao, Qiang Yu
OBJECTIVE: The aim of this study was to determine the value of combining conventional MRI, diffusion-weighted (DWI) and dynamic contrast enhanced MRI (DCE-MRI) in diagnosing solid neoplasms in the parotid gland. METHODS: A total of 148 subjects (101 with benign and 47 with malignant tumors) were evaluated with conventional MRI, DWI and DCE-MRI prior to surgery and pathologic verification. The items observed with conventional MRI included the shape, capsule and signal intensity of parotid masses...
March 16, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28289952/tic-severity-and-treatment-in-children-the-effect-of-comorbid-attention-deficit-hyperactivity-disorder-and-obsessive-compulsive-behaviors
#9
Tamara Pringsheim
While attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder have been shown to have major impacts on quality of life in individuals with Tourette syndrome, there is comparatively little data on how the presence of these comorbidities influence tic severity and treatment. 114 children (mean age 10.25 years) were extensively clinically phenotyped at a single specialty clinic. While there was no difference in Yale Global Tic Severity Scale (YGTSS) scores in children with versus without ADHD, children with obsessive compulsive behaviors had significantly higher YGTSS scores (p = 0...
March 13, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28289551/tic-exacerbation-in-adults-with-tourette-syndrome-a-case-series
#10
Sara M Schaefer, Christopher A Chow, Elan D Louis, Daphne Robakis
BACKGROUND: Tourette syndrome (TS) has been described as peaking in adolescence with subsequent regression. We report patients who were diagnosed with TS during childhood who experienced a latent period (significant reduction in or absence of tics) followed by tic re-emergence in adulthood. METHODS: We performed a retrospective chart review of outpatients over age 21 seen at the Yale neurology clinic between January 2012 and July 2016 who were diagnosed with childhood-onset tics, and who experienced a latent period of greater than 1 year followed by an exacerbation...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28288328/case-control-exploratory-study-of-cerebrospinal-fluid-chemokines-cytokines-and-lymphocyte-subsets-in-childhood-tourette-syndrome-with-positive-streptococcal-markers
#11
Michael R Pranzatelli, Elizabeth D Tate, Tyler J Allison
A longstanding question is whether neuroinflammation is present in children symptomatic for Tourette syndrome (TS) with positive streptococcal serology and throat cultures. The objective was to directly test for it using modern hypothesis-driven approaches. Profiling studies for 14 immune cell types (flow cytometry), 7 chemokines/cytokines (ELISA), oligoclonal bands, and other immunoglobulins were performed in this IRB-approved study of 5 children with TS and streptococcal markers compared to data from 26 non-inflammatory pediatric neurological controls...
March 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28287611/fam83a-is-amplified-and-promotes-cancer-stem-cell-like-traits-and-chemoresistance-in-pancreatic-cancer
#12
S Chen, J Huang, Z Liu, Q Liang, N Zhang, Y Jin
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), contribute to tumorigenesis, resistance to chemoradiotherapy and recurrence in human cancers, suggesting targeting CSCs may represent a potential therapeutic strategy. In the current study, we found family with sequence similarity 83, member A (FAM83A) is significantly overexpressed and associated with poorer overall survival and disease-free survival in pancreatic cancer. Overexpression of FAM83A markedly promoted, whereas inhibition of FAM83A decreased, CSC-like traits and chemoresistance both in vitro and in an in vivo mouse model of pancreatic cancer...
March 13, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28285739/neuropsychiatric-comorbidities-in-adults-with-phenylketonuria-a-retrospective-cohort-study
#13
Deborah A Bilder, Joyce A Kobori, Jessica L Cohen-Pfeffer, Erin M Johnson, Elaina R Jurecki, Mitzie L Grant
Adults with phenylketonuria (PKU) may experience neurologic and psychiatric disorders, including intellectual disability, anxiety, depression, and neurocognitive dysfunction. Identifying the prevalence and prevalence ratios of these conditions will inform clinical treatment. This nested, case-controlled study used International Classification of Diseases, Ninth Revision (ICD-9) codes from the MarketScan® insurance claims databases from 2006 to 2012 and healthcare claims data for US-based employer and government-sponsored health plans...
March 6, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28285251/neurodevelopmental-disorders-in-young-violent-offenders-overlap-and-background-characteristics
#14
Eva Billstedt, Henrik Anckarsäter, Märta Wallinius, Björn Hofvander
Neurodevelopmental disorders (Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), tic disorder, intellectual disability (ID)), in prison populations have received increased attention but the focus has generally been on one single condition leaving out the global picture. This study assessed the prevalence and overlap of neurodevelopmental disorders (NDD) in a consecutive cohort (n=270) of young adult male offenders (age 18-25 years), sentenced for "hands-on" violent offences and serving prison time in Swedish prisons...
March 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28283569/the-novel-chloroplast-outer-membrane-kinase-koc1-is-a-required-component-of-the-plastid-protein-import-machinery
#15
Mónica Zufferey, Cyrille Montandon, Véronique Douet, Emilie Demarsy, Birgit Agne, Sacha Baginsky, Felix Kessler
The biogenesis and maintenance of cell organelles such as mitochondria and chloroplasts requires the import of many proteins from the cytosol, a process that is controlled by phosphorylation. In the case of chloroplasts, the import of hundreds of different proteins depends on Translocons at the Outer and Inner Chloroplast membrane (TOC and TIC, respectively) complexes. The essential protein TOC159 functions thereby as an import receptor. It has an N-terminal acidic (A) domain that extends into the cytosol, controls receptor specificity, and is highly phosphorylated in vivo...
March 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28280480/the-efficacy-and-tolerability-of-the-clonidine-transdermal-patch-in-the-treatment-for-children-with-tic-disorders-a-prospective-open-single-group-self-controlled-study
#16
Pan-Pan Song, Li Jiang, Xiu-Juan Li, Si-Qi Hong, Shuang-Zi Li, Yue Hu
BACKGROUND: To evaluate the efficacy and tolerability of a clonidine transdermal patch in the treatment of children with tic disorders (TD) and to establish a predictive model for patients. METHODS: Forty-one patients who met the inclusion criteria entered into 12 weeks of prospective, open, single-group, self-controlled treatment with a clonidine transdermal patch. The Yale Global Tic Severity Scale (YGTSS) was employed before therapy (baseline) and at 4, 8, and 12 weeks after therapy...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28272733/-an-update-on-the-pharmacological-treatment-of-attention-deficit-hyperactivity-disorder-lisdexamphetamine-and-extended-release-guanfacine
#17
REVIEW
D Martin Fernandez-Mayoralas, A L Fernandez-Perrone, N Munoz-Jareno, A Fernandez-Jaen
INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental disorders in the child population. Its treatment is complex and must include psychoeducational, environmental and pharmacological measures. In recent years, the main novelties as regards its pharmacological treatment have been the appearance of lisdexamphetamine and extended-release guanfacine. AIMS: The increase in the number of drugs available for the treatment of ADHD makes it possible to treat and cover a very wide range of different clinical situations...
March 13, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28272727/-an-unusual-presentation-of-painful-tic-convulsive
#18
S Romano-Feinholz, M P Medina, F E Nares-Lopez, J L Soto-Hernandez, R Revuelta-Gutierrez
INTRODUCTION: The term 'painful tic convulsive' is used to describe the syndrome involving concomitant hemifacial spasm and ipsilateral trigeminal neuralgia. Vascular compression of the fifth and seventh cranial nerves is the most common cause, involving the entry and exit zone of rootlets coming from the brainstem; nevertheless, different etiologies of this syndrome has been previously reported. Treatment for this disease is based on surgical microvascular decompression of the nerve rootlets, but still a topic of debate...
March 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28268393/biomechanical-analysis-of-a-fall-velocities-at-impact
#19
Norbert Noury, Julien Poujaud, Pierre Cousin, Nicolas Poujaud
There are numerous research works focusing on falls of the elderly, proposing various technologies for its detection; however, few research works attempted to describe the mechanical phenomenon itself. In this study, we analyzed the kine(ma)tics of human falls with a simplified biomechanical model of human segments. We present some results based on data found in the literature and in our own laboratory experiments, to conclude that fall velocities at impact can reach values from 3.78 m.s-1 (center of mass) to 6...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268105/prolonged-striatal-disinhibition-as-a-chronic-animal-model-of-tic-disorders
#20
Esther Vinner, Michal Israelashvili, Izhar Bar-Gad
BACKGROUND: Experimental findings and theoretical models have associated Tourette syndrome with abnormal striatal inhibition. The expression of tics, the hallmark symptom of this disorder, has been transiently induced in non-human primates and rodents by the injection of GABAA antagonists into the striatum, leading to temporary disinhibition. NEW METHOD: The novel chronic model of tic expression utilizes mini-osmotic pumps implanted subcutaneously in the rat back for prolonged infusion of bicuculline into the dorsolateral striatum...
March 4, 2017: Journal of Neuroscience Methods
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