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https://www.readbyqxmd.com/read/28081231/physical-activity-energy-expenditure-nutritional-habits-quality-of-sleep-and-stress-levels-in-shift-working-health-care-personnel
#1
Frederick Charles Roskoden, Janine Krüger, Lena Johanna Vogt, Simone Gärtner, Hans Joachim Hannich, Antje Steveling, Markus M Lerch, Ali A Aghdassi
BACKGROUND: Among health care personnel working regular hours or rotating shifts can affect parameters of general health and nutrition. We have investigated physical activity, sleep quality, metabolic activity and stress levels in health care workers from both groups. METHODS: We prospectively recruited 46 volunteer participants from the workforce of a University Medical Department of which 23 worked in rotating shifts (all nursing) and 21 non-shift regular hours (10 nursing, 13 clerical staff)...
2017: PloS One
https://www.readbyqxmd.com/read/28078710/cancer-stem-cells-cscs-in-melanoma-there-s-smoke-but-is-there-fire
#2
REVIEW
Constance E Brinckerhoff
Cancer stem cells (CSCs), also called Tumor Initiating Cells (TICs), can be defined as cancer cells that are present within solid tumors or hematological cancers, which have characteristics associated with normal stem cells, but which can give rise to all cell types found in a particular cancer sample. CSCs, therefore, are transformed stem cells, which can self-renew, differentiate into diverse progenies, and drive continuous tumor growth. (Villani et al. 2015) (Zhou et al., 2009)(Kreso & Dick, 2014)(Schatton et al...
January 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28077676/a-ptk7-targeted-antibody-drug-conjugate-reduces-tumor-initiating-cells-and-induces-sustained-tumor-regressions
#3
Marc Damelin, Alexander Bankovich, Jeffrey Bernstein, Justin Lucas, Liang Chen, Samuel Williams, Albert Park, Jorge Aguilar, Elana Ernstoff, Manoj Charati, Russell Dushin, Monette Aujay, Christina Lee, Hanna Ramoth, Milly Milton, Johannes Hampl, Sasha Lazetic, Virginia Pulito, Edward Rosfjord, Yongliang Sun, Lindsay King, Frank Barletta, Alison Betts, Magali Guffroy, Hadi Falahatpisheh, Christopher J O'Donnell, Robert Stull, Marybeth Pysz, Paul Escarpe, David Liu, Orit Foord, Hans Peter Gerber, Puja Sapra, Scott J Dylla
Disease relapse after treatment is common in triple-negative breast cancer (TNBC), ovarian cancer (OVCA), and non-small cell lung cancer (NSCLC). Therapies that target tumor-initiating cells (TICs) should improve patient survival by eliminating the cells that can drive tumor recurrence and metastasis. We demonstrate that protein tyrosine kinase 7 (PTK7), a highly conserved but catalytically inactive receptor tyrosine kinase in the Wnt signaling pathway, is enriched on TICs in low-passage TNBC, OVCA, and NSCLC patient-derived xenografts (PDXs)...
January 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28074882/immunomagnetic-separation-of-tumor-initiating-cells-by-screening-two-surface-markers
#4
Chen Sun, Yuan-Pang Hsieh, Sai Ma, Shuo Geng, Zhenning Cao, Liwu Li, Chang Lu
Isolating tumor initiating cells (TICs) often requires screening of multiple surface markers, sometimes with opposite preferences. This creates a challenge for using bead-based immunomagnetic separation (IMS) that typically enriches cells based on one abundant marker. Here, we propose a new strategy that allows isolation of CD44(+)/CD24(-) TICs by IMS involving both magnetic beads coated by anti-CD44 antibody and nonmagnetic beads coated by anti-CD24 antibody (referred to as two-bead IMS). Cells enriched with our approach showed significant enhancement in TIC marker expression (examined by flow cytometry) and improved tumorsphere formation efficiency...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074769/-neuroradiological-changes-by-suppression-of-tics
#5
Sara Bohn Larsen, Camilla Birgitte Sørensen, Liselotte Skov, Nanette Mol Debes
Tourette's syndrome is characterized by involuntary tics. First choice of treatment has been pharmacological, but recently, behavioural therapy teaching patients to suppress their tics has been introduced. Neuroimaging studies have shown an increased activity in the prefrontal cortex, temporal lobes and caudate nucleus, and a decreased activity in globus pallidus and putamen during inhibition of tics. The activity in the frontal lobes changes with age, probably caused by a lack of compensatory hypertrophy. In order to fully understand the mechanism behind behavioural therapy further studies are needed...
January 2, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28071825/systematic-review-of-severity-scales-and-screening-instruments-for-tics-critique-and-recommendations
#6
Davide Martino, Tamara M Pringsheim, Andrea E Cavanna, Carlo Colosimo, Andreas Hartmann, James F Leckman, Sheng Luo, Alexander Munchau, Christopher G Goetz, Glenn T Stebbins, Pablo Martinez-Martin
BACKGROUND: Several clinician, informant, and self-report instruments for tics and associated phenomena have been developed that differ in construct, comprehensiveness, and ease of administration. OBJECTIVE: A Movement Disorders Society subcommittee aimed to rate psychometric quality of severity and screening instruments for tics and related sensory phenomena. METHODS: Following the methodology adopted by previous Movement Disorders Society subcommittee papers, a review of severity and screening instruments for tics was completed, applying a classification as "recommended," "suggested," or "listed" to each instrument...
January 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28070162/contrast-enhanced-ultrasonography-in-evaluation-of-the-therapeutic-effect-of-chemotherapy-for-patients-with-liver-metastases
#7
Naoyuki Ueda, Haruki Nagira, Naoko Sannomiya, Saeko Ikunishi, Yuiko Hattori, Akira Kamida, Yuki Koyanagi, Kenta Shimabayashi, Kengo Sato, Hiroaki Saito, Yasuaki Hirooka
BACKGROUND: The therapeutic effect of chemotherapy for liver metastases is currently determined by changes in tumor diameter depicted on computed tomography (CT) and magnetic resonance imaging, but it cannot accurately determine if there is central necrosis. Furthermore, due to the risk of radiation exposure and high cost, frequent examination using these methods places a heavy burden on patients. Meanwhile, real-time observation of blood flow and vessel morphology within tumors has become possible by contrast-enhanced ultrasonography (CEUS)...
December 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/28067618/structure-and-function-of-the-mycobacterial-transcription-initiation-complex-with-the-essential-regulator-rbpa
#8
Elizabeth A Hubin, Allison Fay, Catherine Xu, James M Bean, Ruth M Saecker, Michael S Glickman, Seth A Darst, Elizabeth A Campbell
RbpA and CarD are essential transcription regulators in mycobacteria. Mechanistic analyses of promoter open complex (RPo) formation establish thatRbpA and CarD cooperatively stimulate formation of anintermediate (RP2) leading to RPo; formation of RP2 islikely a bottleneck step at the majority of mycobacterial promoters. Once RPo forms, CarD also disfavors its isomerization back to RP2.We determined a 2.76 Å-resolution crystal structure of a mycobacterial transcription initiation complex (TIC) with RbpA as well as a CarD/RbpA/TIC model...
January 9, 2017: ELife
https://www.readbyqxmd.com/read/28059107/single-cell-time-lapse-analysis-reveals-that-podoplanin-enhances-cell-survival-and-colony-formation-capacity-of-squamous-cell-carcinoma-cells
#9
Tomoyuki Miyashita, Youichi Higuchi, Motohiro Kojima, Atsushi Ochiai, Genichiro Ishii
Tumor initiating cells (TICs) are characterized by high clonal expansion capacity. We previously reported that podoplanin is a TIC-specific marker for the human squamous cell carcinoma cell line A431. The aim of this study is to explore the molecular mechanism underlying the high clonal expansion potential of podoplanin-positive A431cells using Fucci imaging. Single podoplanin-positive cells created large colonies at a significantly higher frequency than single podoplanin-negative cells, whereas no difference was observed between the two types of cells with respect to cell cycle status...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28058728/untargeted-metabolomic-profiling-of-seminal-plasma-in-non-obstructive-azoospermia-men-a-non-invasive-detection-of-spermatogenesis
#10
Kambiz Gilany, Ahmad Mani-Varnosfaderani, Arash Minai-Tehrani, Fateme Mirzajani, Alireza Ghassempour, Mohammed Reza Sadeghi, Mehdi Amini, Hassan Rezadoost
Male factor infertility is involved in almost half of all infertile couples. Lack of the ejaculated sperm due to testicular malfunction has been reported in 6-10% of infertile, a condition named non-obstructive azoospermia (NOA). In this study, we investigated untargeted metabolomic profiling of the seminal plasma in NOA men using gas chromatography-mass spectrometry (GC-MS) and advance chemometrics. In this regard, the seminal plasma fluids of 11 NOA men with TESE-negative (AZN), 9 NOA men with TESE-positive (AZP) and 10 fertile (F) healthy men (as a control group) were collected...
January 6, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28054659/hardness-of-cubic-solid-solutions
#11
Faming Gao
We demonstrate that a hardening rule exists in cubic solid solutions with various combinations of ionic, covalent and metallic bonding. It is revealed that the hardening stress ∆τFcg is determined by three factors: shear modulus G, the volume fraction of solute atoms fv, and the size misfit degree δb. A simple hardening correlation in KCl-KBr solid-solution is proposed as ∆τFcg = 0.27 G. It is applied to calculate the hardening behavior of the Ag-Au, KCl-KBr, InP-GaP, TiN-TiC, HfN-HfC, TiC-NbC and ZrC-NbC solid-solution systems...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28054361/the-metabolic-sensor-akin10-modulates-the-arabidopsis-circadian-clock-in-a-light-dependent-manner
#12
Jieun Shin, Alfredo Sánchez-Villarreal, Amanda M Davis, Shen-Xiu Du, Kenneth W Berendzen, Csaba Koncz, Zhaojun Ding, Cuiling Li, Seth J Davis
Plants generate rhythmic metabolism during the repetitive day/night cycle. The circadian clock produces internal biological rhythms to synchronize numerous metabolic processes such that they occur at the required time of day. Metabolism conversely influences clock function by controlling circadian period and phase, and the expression of core-clock genes. Here we show that AKIN10, a catalytic subunit of the evolutionarily conserved key energy sensor Snf1 (sucrose non-fermenting 1)-related kinase 1 (SnRK1) complex, plays an important role in the circadian clock...
January 5, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28052035/brca1-iris-overexpression-promotes-and-maintains-the-tumor-initiating-phenotype-implications-for-triple-negative-breast-cancer-early-lesions
#13
Abhilasha Sinha, Bibbin T Paul, Lisa M Sullivan, Hillary Sims, Ahmed El Bastawisy, Hend F Yousef, Abdel-Rahman N Zekri, Abeer A Bahnassy, Wael M ElShamy
Tumor-initiating cells (TICs) are cancer cells endowed with self-renewal, multi-lineage differentiation, increased chemo-resistance, and in breast cancers the CD44+/CD24-/ALDH1+ phenotype. Triple negative breast cancers show lack of BRCA1 expression in addition to enhanced basal, epithelial-to-mesenchymal transition (EMT), and TIC phenotypes. BRCA1-IRIS (hereafter IRIS) is an oncogene produced by the alternative usage of the BRCA1 locus. IRIS is involved in induction of replication, transcription of selected oncogenes, and promoting breast cancer cells aggressiveness...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28045563/multivariable-regression-model-of-the-euroqol-5-dimension-questionnaire-in-patients-seeking-outpatient-low-vision-rehabilitation
#14
Alexis G Malkin, Judith E Goldstein, Robert W Massof
PURPOSE: To understand the source of between-person variance in baseline health utilities estimated from EuroQol 5-dimension questionnaire (EQ-5D) responses of a representative sample of the US low vision outpatient population prior to rehabilitation. METHODS: A prospective, observational study of 779 new low vision patients at 28 clinic centers in the US. The EQ-5D, Activity Inventory (AI), Telephone Interview for Cognitive Status (TICS), Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) physical functioning component, and Geriatric Depression Scale (GDS) were administered by telephone interview prior to rehabilitation...
January 3, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28045379/xps-investigation-of-titanium-contact-formation-to-zno-nanowires
#15
Chris Barnett, Ambroise Casting, Daniel Jones, Aled Lewis, Lewys Jenkins, Richard Cobley, Thierry Maffeis
Ti is often used to form an initial Ohmic interface between ZnO and Au due to its low work function, and the TiO<sub>2</sub>/ZnO heterojunction is also of great importance for many practical applications of nanoparticles. Here, Ti has been controllably deposited onto hydrothermally grown ZnO nanowires and the formation of metal-semiconductor contact has been investigated using x-ray photoelectron spectroscopy (XPS), photoluminescence (PL) spectroscopy and scanning electron microscopy (SEM). XPS results showed that that the Ti initially reacts with surface oxygen species to form TiO<sub>2</sub>, and further deposition results in the formation of oxides with oxidation state numbers lower than four, and eventually metallic Ti on top of the TiO<sub>2</sub>...
January 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28039814/specific-executive-control-impairments-in-tourette-syndrome-the-role-of-response-inhibition
#16
Asaf Yaniv, Noa Benaroya-Milshtein, Tamar Steinberg, Dafna Ruhrrman, Alan Apter, Michal Lavidor
BACKGROUND: Tourette syndrome (TS) is a childhood-onset disorder characterized by motor and vocal tics. While cognitive features of common comorbid conditions such as attention deficit hyperactive disorder and obsessive compulsive disorder have been widely investigated, the cognitive profile of TS patients remains to be precisely defined. In this regard, the executive functions system (EF) is of especial interest. AIMS: The aim of the study was to delineate the various components of executive processes in adult TS patients...
December 28, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28038439/revisiting-stigma-exposure-to-tourette-in-an-ordinary-setting-increases-stigmatization
#17
Menachem Ben-Ezra, Sharon Anavi-Goffer, Ella Arditi, Pazit Ron, Rachel Paryenta Atia, Yonat Rate, Krzysztof Kaniasty
Stigma toward people with mental disorders is frequently studied yet less is known about prejudice toward persons with tic disorders, especially sufferers of Gilles de la Tourette Syndrome (GTS). We examined stigmatizing attributions concerning a GTS patient in an online study with participants randomly assigned to one of two video clip conditions: the experimental group saw to a person with Tourette syndrome; the control group watched a nature scenic footage. Results revealed that participants in the experimental condition exhibited higher scores on a stigma questionnaire...
November 29, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28032854/do-cannabinoids-have-a-role-to-play-in-tourette%C3%A2-s-syndrome
#18
Karen García, Gabriel Rada
It has been suggested that the use of cannabinoids might play a role in the treatment of Tourette’s syndrome, but there is no consensus. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified seven systematic reviews including two randomized trials addressing the question of this article. We extracted data, combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded it is not clear whether cannabinoids reduce tics in Tourette’s syndrome, and they are probably associated to frequent adverse effects...
December 9, 2016: Medwave
https://www.readbyqxmd.com/read/28032202/pediatric-obsessive-compulsive-disorder-with-tic-symptoms-clinical-presentation-and-treatment-outcome
#19
Davíð R M A Højgaard, Gudmundur Skarphedinsson, Judith Becker Nissen, Katja A Hybel, Tord Ivarsson, Per Hove Thomsen
: Some studies have shown that children and adolescents with obsessive-compulsive disorder (OCD) and co-morbid tics differ from those without co-morbid tics in terms of several demographic and clinical characteristics. However, not all studies have confirmed these differences. This study examined children and adolescents with OCD and with possible or definite tic specifiers according to the DSM-5 in order to see whether they differ from patients without any tic symptoms regarding clinical presentation and outcome of cognitive behavioral therapy (CBT)...
December 28, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28031527/tumor-initiating-cells-of-breast-and-prostate-origin-show-alterations-in-the-expression-of-genes-related-to-iron-metabolism
#20
Zuzana Rychtarcikova, Sandra Lettlova, Veronika Tomkova, Vlasta Korenkova, Lucie Langerova, Ekaterina Simonova, Polina Zjablovskaja, Meritxell Alberich-Jorda, Jiri Neuzil, Jaroslav Truksa
The importance of iron in the growth and progression of tumors has been widely documented. In this report, we show that tumor-initiating cells (TICs), represented by spheres derived from the MCF7 cell line, exhibit higher intracellular labile iron pool, mitochondrial iron accumulation and are more susceptible to iron chelation. TICs also show activation of the IRP/IRE system, leading to higher iron uptake and decrease in iron storage, suggesting that level of properly assembled cytosolic iron-sulfur clusters (FeS) is reduced...
December 22, 2016: Oncotarget
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