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https://www.readbyqxmd.com/read/28211592/a-methodology-for-assessing-deployment-trauma-and-its-consequences-in-oef-oif-ond-veterans-the-tracts-longitudinal-prospective-cohort-study
#1
Regina E McGlinchey, William P Milberg, Jennifer R Fonda, Catherine Brawn Fortier
Many US veterans of Afghanistan and Iraq have multiple physical and psychiatric problems. A major focus of research has been on determining the effects of mild Traumatic Brain Injury (mTBI), but mTBI is rarely diagnosed in the absence of co-occurring conditions such as blast exposure, post-traumatic stress disorder (PTSD), depression, substance abuse, etc. These potentially interactive psychological and physical conditions produce complex patterns of cognitive, psychological, and physical symptoms that impede civilian reintegration and complicate efficient and effective treatment planning...
February 17, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28195958/rehospitalization-in-the-first-year-following-veteran-and-service-member-tbi-a-va-tbi-model-systems-study
#2
Johanna Tran, Flora Hammond, Kristen Dams-OʼConnor, Xinyu Tang, Blessen Eapen, Marissa McCarthy, Risa Nakase-Richardson
OBJECTIVE: To determine the incidence and causes of rehospitalization following military or Veteran traumatic brain injury (TBI). SETTING: Department of Veterans Affairs (VA) Veterans Health Administration Polytrauma Rehabilitation Centers (VHA PRCs). PARTICIPANTS: Consecutive sample of VHA TBI Model System participants (N = 401). DESIGN: Prospective observational cohort study. MAIN MEASURES: Number and type of rehospitalizations in first year post-TBI...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28135424/traumatic-brain-injury-incidence-clinical-overview-and-policies-in-the-us-military-health-system-since-2000
#3
Thomas M Swanson, Brad M Isaacson, Cherina M Cyborski, Louis M French, Jack W Tsao, Paul F Pasquina
Exposure to explosive armaments during Operation Iraqi Freedom and Operation Enduring Freedom contributed to approximately 14% of the 352 612 traumatic brain injury (TBI) diagnoses in the US military between 2000 and 2016. The US Department of Defense issued guidelines in 2009 to (1) standardize TBI diagnostic criteria; (2) classify TBI according to mechanism and severity; (3) categorize TBI symptoms as somatic, psychological, or cognitive; and (4) systematize types of care given during the acute and rehabilitation stages of TBI treatment...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28121256/traumatic-brain-injury-in-iraq-and-afghanistan-veterans-new-results-from-a-national-random-sample-study
#4
Lisa K Lindquist, Holly C Love, Eric B Elbogen
This study randomly sampled post-9/11 military veterans and reports on causes, predictors, and frequency of traumatic brain injury (TBI) (N=1,388). A total of 17.3% met criteria for TBI during military service, with about one-half reporting multiple head injuries, which were related to higher rates of posttraumatic stress disorder, depression, back pain, and suicidal ideation. The most common mechanisms of TBI included blasts (33.1%), objects hitting head (31.7%), and fall (13.5%). TBI was associated with enlisted rank, male gender, high combat exposure, and sustaining TBI prior to military service...
January 25, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28098495/psychometric-characteristics-of-the-insomnia-severity-index-in-veterans-with-history-of-traumatic-brain-injury
#5
Christopher N Kaufmann, Henry J Orff, Raeanne C Moore, Lisa Delano-Wood, Colin A Depp, Dawn M Schiehser
OBJECTIVE/BACKGROUND: The Insomnia Severity Index (ISI) is a widely used self-report measure of insomnia symptoms. However, to date this measure has not been validated or well-characterized in veterans who have experienced traumatic brain injury (TBI). This study assessed the psychometric properties and convergent, divergent, construct, and discriminate validity of the ISI in veterans with a history of TBI. PARTICIPANTS: Eighty-three veterans with history of TBI were seen in the VA San Diego Healthcare System as part of a research protocol...
January 18, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28060206/tbi-and-treatment-response-in-a-randomized-trial-of-acceptance-and-commitment-therapy
#6
Jessica Bomyea, Ariel J Lang, Paula P Schnurr
OBJECTIVE: Traumatic brain injury (TBI) occurs in a substantial minority of military personnel, and commonly is associated with mental health disorders and postconcussive symptoms (PCS). The implications of TBI for mental health treatment are not well understood. The present study sought to describe psychotherapy response in veterans with and without TBI. DESIGN: This is a secondary analysis from a 2-group randomized controlled trial. SETTING, PARTICIPANTS, AND MEASURES: One hundred and sixty male and female veterans participated in a multisite randomized controlled trial of Acceptance and Commitment Therapy versus Present Centered Therapy; a subset of 129 veterans were included in these analyses...
January 5, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/27997672/caring-for-our-wounded-warriors-a-qualitative-examination-of-health-related-quality-of-life-in-caregivers-of-individuals-with-military-related-traumatic-brain-injury
#7
Noelle E Carlozzi, Tracey A Brickell, Louis M French, Angelle Sander, Anna L Kratz, David S Tulsky, Nancy D Chiaravalloti, Elizabeth A Hahn, Michael Kallen, Amy M Austin, Jennifer A Miner, Rael T Lange
The purpose of this study was to develop a conceptual framework that captures aspects of health-related quality of life (HRQOL) for caregivers of individuals with military-related traumatic brain injury (TBI). We analyzed qualitative data from nine focus groups composed of caregivers of wounded warriors with a medically documented TBI. Focus group participants were recruited through hospital-based and/or community outreach efforts at the Walter Reed National Military Medical Center, the University of Michigan, and Hearts of Valor support groups (Tennessee and Washington)...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27986702/a-systems-science-approach-to-understanding-polytrauma-and-blast-related-injury-bayesian-network-model-of-data-from-a-survey-of-the-florida-national-guard
#8
Peter A Toyinbo, Rodney D Vanderploeg, Heather G Belanger, Andrea M Spehar, William A Lapcevic, Steven G Scott
We sought to further define the epidemiology of the complex, multiple injuries collectively known as polytrauma/blast-related injury (PT/BRI). Using a systems science approach, we performed Bayesian network modeling to find the most accurate representation of the complex system of PT/BRI and identify key variables for understanding the subsequent effects of blast exposure in a sample of Florida National Guard members (1,443 deployed to Operation Enduring Freedom/Operation Iraqi Freedom and 1,655 not deployed) who completed an online survey during the period from 2009 to 2010...
January 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27931783/reduced-p3b-brain-response-during-sustained-visual-attention-is-associated-with-remote-blast-mtbi-and-current-ptsd-in-u-s-military-veterans
#9
Casey S Gilmore, Craig A Marquardt, Seung Suk Kang, Scott R Sponheim
Approximately 275,000 American service members deployed to Iraq or Afghanistan have sustained a mild traumatic brain injury (mTBI), with 75% of these incidents involving an explosive blast. Combat-related mTBI is frequently associated with comorbid mental health disorders, especially posttraumatic stress disorder (PTSD). Attention problems, including sustained attention, are common cognitive complaints of veterans with TBI and PTSD. The present study sought to examine neural correlates of sustained attention in veterans with blast mTBI and/or current PTSD...
December 5, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27903275/cell-cycle-inhibition-reduces-inflammatory-responses-neuronal-loss-and-cognitive-deficits-induced-by-hypobaria-exposure-following-traumatic-brain-injury
#10
Jacob W Skovira, Junfang Wu, Jessica J Matyas, Alok Kumar, Marie Hanscom, Shruti V Kabadi, Raymond Fang, Alan I Faden
BACKGROUND: Traumatic brain injury (TBI) patients in military settings can be exposed to prolonged periods of hypobaria (HB) during aeromedical evacuation. Hypobaric exposure, even with supplemental oxygen to prevent hypoxia, worsens outcome after experimental TBI, in part by increasing neuroinflammation. Cell cycle activation (CCA) after TBI has been implicated as a mechanism contributing to both post-traumatic cell death and neuroinflammation. Here, we examined whether hypobaric exposure in rats subjected to TBI increases CCA and microglial activation in the brain, as compared to TBI alone, and to evaluate the ability of a cyclin-dependent kinase (CDK) inhibitor (CR8) to reduce such changes and improve behavioral outcomes...
December 1, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27901414/cognitive-deficits-and-inflammatory-response-resulting-from-mild-to-moderate-traumatic-brain-injury-in-rats-are-exacerbated-by-repeated-pre-exposure-to-an-innate-stress-stimulus
#11
Michaël Ogier, Amor Belmeguenai, Thomas Lieutaud, Béatrice Georges, Sandrine Bouvard, Emilie Carré, Frédéric Canini, Laurent Bezin
Traumatic brain injury (TBI) is common in both military and civilian populations, and often results in neurobehavioral sequelae that impair quality of life in both patients and their families. Although individuals who are chronically exposed to stress are more likely to experience TBI, it is still unknown whether pre-injury stress influences the outcome after TBI. The present study tested whether behavioral and cognitive long-term outcome after TBI in rats is affected by prior exposure to an innate stress stimulus...
January 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27863701/the-many-wounds-of-war-the-association-of-service-related-and-clinical-characteristics-with-problems-with-the-law-in-iraq-and-afghanistan-veterans
#12
Autumn Backhaus, Shadi Gholizadeh, Kathryn M Godfrey, James Pittman, Niloofar Afari
Previous research has demonstrated that veterans with posttraumatic stress disorder (PTSD) are at higher risk for aggression, hostility, and anger, potentially leading to problems with the law or disciplinary action while in the military. There have been calls for increased consideration of the unique aspects of the judicial system in legal matters with veterans involved. The bulk of the research so far has considered the link between PTSD, traumatic brain injury (TBI), and combat exposure, but little is known about the potential role of chronic pain and Military Sexual Trauma (MST) in a veteran's experience of anger, aggression, and discipline while in the military and legal concerns...
November 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/27834544/active-duty-service-members-who-sustain-a-traumatic-brain-injury-have-chronically-elevated-peripheral-concentrations-of-a%C3%AE-40-and-lower-ratios-of-a%C3%AE-42-40
#13
Natasha Lejbman, Anlys Olivera, Morgan Heinzelmann, Rebekah Feng, Sijung Yun, Hyung-Suk Kim, Jessica Gill
PRIMARY OBJECTIVE: Excessive accumulation of amyloid beta (Aβ) and tau have been observed in older individuals with chronic neurological symptoms related to a traumatic brain injury (TBI), yet little is known about the possible role of Aβ in younger active duty service members following a TBI. The purpose of the study was to determine if Aβ 40 or 42 related to sustaining a TBI or to chronic neurological symptoms in a young cohort of military personnel. RESEARCH DESIGN: This was a cross-sectional study of active duty service members who reported sustaining a TBI and provided self-report of neurological and psychological symptoms and provided blood...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27799776/hyperbaric-oxygen-therapy-as-a-potential-treatment-for-post-traumatic-stress-disorder-associated-with-traumatic-brain-injury
#14
REVIEW
David J Eve, Martin R Steele, Paul R Sanberg, Cesar V Borlongan
Traumatic brain injury (TBI) describes the presence of physical damage to the brain as a consequence of an insult and frequently possesses psychological and neurological symptoms depending on the severity of the injury. The recent increased military presence of US troops in Iraq and Afghanistan has coincided with greater use of improvised exploding devices, resulting in many returning soldiers suffering from some degree of TBI. A biphasic response is observed which is first directly injury-related, and second due to hypoxia, increased oxidative stress, and inflammation...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27794484/prospective-tracking-and-analysis-of-traumatic-brain-injury-in-veterans-and-military-personnel
#15
Nytzia E Licona, Joyce S Chung, John H Poole, Rose M Salerno, Nancy M Laurenson, Odette A Harris
OBJECTIVE: To describe the ongoing Clinical Tracking Form (CTF) study of the Defense and Veterans Brain Injury Center (DVBIC). DESIGN: Prospective longitudinal study. Data at baseline and postinjury are collected on participants through interview and questionnaire, review of medical records, and periodic follow-ups throughout their lifetime. SETTING: A regional DVBIC site located at a Veterans Affairs Medical Center. PARTICIPANTS: Participants (N=211; age range, 18-75y) were enrolled between January 1, 2005, and December 31, 2012, at a regional DVBIC site...
February 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27750113/laboratory-impulsivity-and-depression-in-blast-exposed-military-personnel-with-post-concussion-syndrome
#16
James M Bjork, Thomas K Burroughs, Laura M Franke, Treven C Pickett, Sade E Johns, F Gerard Moeller, William C Walker
In military populations, traumatic brain injury (TBI) also holds potential to increase impulsivity and impair mood regulation due to blast injury effects on ventral frontal cortex - to put military personnel at risk for suicide or substance abuse. We assessed a linkage between depression and impaired behavioral inhibition in 117 blast-exposed service members (SM) and veterans with post-concussion syndrome (PCS), where PCS was defined using a Rivermead Postconcussive Symptom Questionnaire (RPQ) modified to clarify whether each symptom worsened compared to pre-blast...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27747799/prevalence-of-central-nervous-system-polypharmacy-and-associations-with-overdose-and-suicide-related-behaviors-in-iraq-and-afghanistan-war-veterans-in-va-care-2010-2011
#17
Garen A Collett, Kangwon Song, Carlos A Jaramillo, Jennifer S Potter, Erin P Finley, Mary Jo Pugh
BACKGROUND: The increase in the quantities of central nervous system (CNS)-acting medications prescribed has coincided with increases in overdose mortality, suicide-related behaviors, and unintentional deaths in military personnel deployed in support of the wars in Iraq and Afghanistan. Data on the extent and impact of prescribing multiple CNS drugs among Iraq and Afghanistan Veterans (IAVs) are sparse. OBJECTIVES: We sought to identify the characteristics of IAVs with CNS polypharmacy and examine the association of CNS polypharmacy with drug overdose and suicide-related behaviors controlling for known risk factors...
March 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27743528/mild-traumatic-brain-injury-and-suicide-risk-among-a-clinical-sample-of-deployed-military-personnel-evidence-for-a-serial-mediation-model-of-anger-and-depression
#18
Ian H Stanley, Thomas E Joiner, Craig J Bryan
Research has demonstrated a robust link between traumatic brain injuries (TBIs) and suicide risk. Yet, few studies have investigated factors that account for this link. Utilizing a clinical sample of deployed military personnel, this study aimed to examine a serial meditation model of anger and depression in the association of mild TBI and suicide risk. A total of 149 military service members referred for evaluation/treatment of a suspected head injury at a military hospital participated in the present study (92...
October 7, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27737725/inflammation-relates-to-chronic-behavioral-and-neurological-symptoms-in-military-with-traumatic-brain-injuries
#19
Christina Devoto, Lindsay Arcurio, Joseph Fetta, Mary Ley, Tamar Rodney, Rebekah Kanefsky, Jessica Gill
Studies have shown that the presence of acute inflammation during recovery is indicative of poor outcomes after a traumatic brain injury (TBI); however, the role of chronic inflammation in predicting post-TBI related symptoms remains poorly understood. The purpose of this study was to compare inflammatory biomarkers (TNF-α, IL-6 and IL-10) in active duty personnel who either sustained or did not sustain a TBI. Service members were also assessed for post-traumatic stress disorder (PTSD), depression, and quality-of-life (QOL) through self-reported measures...
October 12, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27720798/blast-waves-from-detonated-military-explosive-reduce-glur1-and-synaptophysin-levels-in-hippocampal-slice-cultures
#20
Marquitta Smith, Thuvan Piehler, Richard Benjamin, Karen L Farizatto, Morgan C Pait, Michael F Almeida, Vladimir V Ghukasyan, Ben A Bahr
Explosives create shockwaves that cause blast-induced neurotrauma, one of the most common types of traumatic brain injury (TBI) linked to military service. Blast-induced TBIs are often associated with reduced cognitive and behavioral functions due to a variety of factors. To study the direct effects of military explosive blasts on brain tissue, we removed systemic factors by utilizing rat hippocampal slice cultures. The long-term slice cultures were briefly sealed air-tight in serum-free medium, lowered into a 37°C water-filled tank, and small 1...
October 5, 2016: Experimental Neurology
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