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https://www.readbyqxmd.com/read/28329183/remote-traumatic-brain-injury-is-associated-with-motor-dysfunction-in-older-military-veterans
#1
Raquel C Gardner, Carrie B Peltz, Kimbra Kenney, Kenneth E Covinsky, Ramon Diaz-Arrastia, Kristine Yaffe
Background: Traumatic brain injury (TBI) has been identified as a risk factor for Parkinson's disease (PD). Motor dysfunction among TBI-exposed elders without PD has not been well characterized. We sought to determine whether remote TBI is a risk factor for motor dysfunction on exam and functionally relevant motor dysfunction in day-to-day life among independently living elders without PD. Methods: This is a cross-sectional cohort study of independently living retired military veterans aged 50 or older with (n = 78) and without (n = 85) prior TBI-all without diagnosed PD...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28322535/neuropsychological-rehabilitation-and-psychotherapy-of-adult-traumatic-brain-injury-patients-with-depression-a-systematic-review-and-meta-analysis
#2
Zeng-Qiang Liu, Xue Zeng, Chen-Yang Duan
INTRODUCTION: There is still insufficient appreciation whether neuropsychological rehabilitation and psychotherapy are effective in attenuating depression following traumatic brain injury (TBI). This knowledge gap was addressed in the present systematic review and meta- analysis of the literature. EVIDENCE ACQUISITION: We conducted electronic database (Medline, PsychINFO, Scopus) searches (time frame: January 1, 2005 - December 31, 2015) for clinical studies that had tested neuropsychological rehabilitation and psychotherapy in adult TBI survivors with depression...
March 21, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28291465/long-term-outcomes-and-needs-of-military-service-members-after-noncombat-related-traumatic-brain-injury
#3
Kelly J Miller, Jan E Kennedy, Karen A Schwab
OBJECTIVES: Assess the prevalence of self-identified unmet service needs in a military sample an average of 5 years following noncombat traumatic brain injury (TBI). Examine relationships between unmet needs and background, injury-related and outcome variables. METHODS: The study sample consisted of 89 veterans and service members who sustained non-combat TBI between 1999 and 2003, selected from enrollees in the Defense and Veterans Brain Injury Center TBI registry...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28291463/streamlining-participant-recruitment-for-tbi-and-ptsd-research-studies
#4
Shristi Joshi, Kerri Dunbar, Patricia Taylor, Kelli L Sullivan, Mariam M Afzal, Christina Song, Maulik Purohit, Michael J Roy
OBJECTIVES: Recruitment of participants for traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) studies is a major challenge, causing delays in study timelines and even study failures. To address this challenge, the Center for Neuroscience and Regenerative Medicine (CNRM) Recruitment Core developed procedures for identification, screening, and referral of participants from screening studies to a broad range of TBI and PTSD studies. METHODS: Participants were recruited from civilian hospitals, Military Treatment Facilities, and through various events and presentations...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28287287/reporting-of-symptoms-associated-with-concussion-by-oef-oif-ond-veterans-comparison-between-research-and-clinical-contexts
#5
Colleen E Jackson, Leslie Nordstrom, Jennifer R Fonda, Catherine B Fortier, William P Milberg, Regina E McGlinchey
OBJECTIVE: Veterans from recent military conflicts frequently report persisting symptoms associated with concussion well beyond the expected period of recovery following mild traumatic brain injury. This study examined differences in the reporting of symptoms associated with concussion between clinical and research contexts. METHODS: This naturalistic comparison included 91 Veterans from Operations Enduring Freedom (OEF), Iraqi Freedom (OIF) and New Dawn (OND). All participants were enrolled in a longitudinal study focused on traumatic brain injury and stress-related disorders and had also completed a VHA Comprehensive TBI Evaluation...
March 13, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28281095/a-national-study-on-the-effects-of-concussion-in-collegiate-athletes-and-us-military-service-academy-members-the-ncaa-dod-concussion-assessment-research-and-education-care-consortium-structure-and-methods
#6
Steven P Broglio, Michael McCrea, Thomas McAllister, Jaroslaw Harezlak, Barry Katz, Dallas Hack, Brian Hainline
BACKGROUND: The natural history of mild traumatic brain injury (TBI) or concussion remains poorly defined and no objective biomarker of physiological recovery exists for clinical use. The National Collegiate Athletic Association (NCAA) and the US Department of Defense (DoD) established the Concussion Assessment, Research and Education (CARE) Consortium to study the natural history of clinical and neurobiological recovery after concussion in the service of improved injury prevention, safety and medical care for student-athletes and military personnel...
March 9, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28243574/5-year-imaging-sequelae-of-concussive-blast-injury-and-relation-to-early-clinical-outcome
#7
Christine L Mac Donald, Jason Barber, Jalal Andre, Nicole Evans, Chris Panks, Samantha Sun, Kody Zalewski, R Elizabeth Sanders, Nancy Temkin
Current imaging diagnostic techniques are often insensitive to the underlying pathological changes following mild traumatic brain injury (TBI) or concussion so much so that the explicit definition of these uncomplicated mild brain injuries includes the absence of radiological findings. In the US military, this is complicated by the natural tendency of service members to down play symptoms for fear of removal from their unit particularly in combat making it challenging for clinicians to definitively diagnose and determine course of treatment...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28211592/a-methodology-for-assessing-deployment-trauma-and-its-consequences-in-oef-oif-ond-veterans-the-tracts-longitudinal-prospective-cohort-study
#8
Regina E McGlinchey, William P Milberg, Jennifer R Fonda, Catherine Brawn Fortier
Many US veterans of Afghanistan and Iraq have multiple physical and psychiatric problems. A major focus of research has been on determining the effects of mild Traumatic Brain Injury (mTBI), but mTBI is rarely diagnosed in the absence of co-occurring conditions such as blast exposure, post-traumatic stress disorder (PTSD), depression, substance abuse, etc. These potentially interactive psychological and physical conditions produce complex patterns of cognitive, psychological, and physical symptoms that impede civilian reintegration and complicate efficient and effective treatment planning...
February 17, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28195958/rehospitalization-in-the-first-year-following-veteran-and-service-member-tbi-a-va-tbi-model-systems-study
#9
Johanna Tran, Flora Hammond, Kristen Dams-OʼConnor, Xinyu Tang, Blessen Eapen, Marissa McCarthy, Risa Nakase-Richardson
OBJECTIVE: To determine the incidence and causes of rehospitalization following military or Veteran traumatic brain injury (TBI). SETTING: Department of Veterans Affairs (VA) Veterans Health Administration Polytrauma Rehabilitation Centers (VHA PRCs). PARTICIPANTS: Consecutive sample of VHA TBI Model System participants (N = 401). DESIGN: Prospective observational cohort study. MAIN MEASURES: Number and type of rehospitalizations in first year post-TBI...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28135424/traumatic-brain-injury-incidence-clinical-overview-and-policies-in-the-us-military-health-system-since-2000
#10
Thomas M Swanson, Brad M Isaacson, Cherina M Cyborski, Louis M French, Jack W Tsao, Paul F Pasquina
Exposure to explosive armaments during Operation Iraqi Freedom and Operation Enduring Freedom contributed to approximately 14% of the 352 612 traumatic brain injury (TBI) diagnoses in the US military between 2000 and 2016. The US Department of Defense issued guidelines in 2009 to (1) standardize TBI diagnostic criteria; (2) classify TBI according to mechanism and severity; (3) categorize TBI symptoms as somatic, psychological, or cognitive; and (4) systematize types of care given during the acute and rehabilitation stages of TBI treatment...
March 2017: Public Health Reports
https://www.readbyqxmd.com/read/28121256/traumatic-brain-injury-in-iraq-and-afghanistan-veterans-new-results-from-a-national-random-sample-study
#11
Lisa K Lindquist, Holly C Love, Eric B Elbogen
This study randomly sampled post-9/11 military veterans and reports on causes, predictors, and frequency of traumatic brain injury (TBI) (N=1,388). A total of 17.3% met criteria for TBI during military service, with about one-half reporting multiple head injuries, which were related to higher rates of posttraumatic stress disorder, depression, back pain, and suicidal ideation. The most common mechanisms of TBI included blasts (33.1%), objects hitting head (31.7%), and fall (13.5%). TBI was associated with enlisted rank, male gender, high combat exposure, and sustaining TBI prior to military service...
January 25, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28098495/psychometric-characteristics-of-the-insomnia-severity-index-in-veterans-with-history-of-traumatic-brain-injury
#12
Christopher N Kaufmann, Henry J Orff, Raeanne C Moore, Lisa Delano-Wood, Colin A Depp, Dawn M Schiehser
OBJECTIVE/BACKGROUND: The Insomnia Severity Index (ISI) is a widely used self-report measure of insomnia symptoms. However, to date this measure has not been validated or well-characterized in veterans who have experienced traumatic brain injury (TBI). This study assessed the psychometric properties and convergent, divergent, construct, and discriminate validity of the ISI in veterans with a history of TBI. PARTICIPANTS: Eighty-three veterans with history of TBI were seen in the VA San Diego Healthcare System as part of a research protocol...
January 18, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28060206/tbi-and-treatment-response-in-a-randomized-trial-of-acceptance-and-commitment-therapy
#13
Jessica Bomyea, Ariel J Lang, Paula P Schnurr
OBJECTIVE: Traumatic brain injury (TBI) occurs in a substantial minority of military personnel, and commonly is associated with mental health disorders and postconcussive symptoms (PCS). The implications of TBI for mental health treatment are not well understood. The present study sought to describe psychotherapy response in veterans with and without TBI. DESIGN: This is a secondary analysis from a 2-group randomized controlled trial. SETTING, PARTICIPANTS, AND MEASURES: One hundred and sixty male and female veterans participated in a multisite randomized controlled trial of Acceptance and Commitment Therapy versus Present Centered Therapy; a subset of 129 veterans were included in these analyses...
January 5, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/27997672/caring-for-our-wounded-warriors-a-qualitative-examination-of-health-related-quality-of-life-in-caregivers-of-individuals-with-military-related-traumatic-brain-injury
#14
Noelle E Carlozzi, Tracey A Brickell, Louis M French, Angelle Sander, Anna L Kratz, David S Tulsky, Nancy D Chiaravalloti, Elizabeth A Hahn, Michael Kallen, Amy M Austin, Jennifer A Miner, Rael T Lange
The purpose of this study was to develop a conceptual framework that captures aspects of health-related quality of life (HRQOL) for caregivers of individuals with military-related traumatic brain injury (TBI). We analyzed qualitative data from nine focus groups composed of caregivers of wounded warriors with a medically documented TBI. Focus group participants were recruited through hospital-based and/or community outreach efforts at the Walter Reed National Military Medical Center, the University of Michigan, and Hearts of Valor support groups (Tennessee and Washington)...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27986702/a-systems-science-approach-to-understanding-polytrauma-and-blast-related-injury-bayesian-network-model-of-data-from-a-survey-of-the-florida-national-guard
#15
Peter A Toyinbo, Rodney D Vanderploeg, Heather G Belanger, Andrea M Spehar, William A Lapcevic, Steven G Scott
We sought to further define the epidemiology of the complex, multiple injuries collectively known as polytrauma/blast-related injury (PT/BRI). Using a systems science approach, we performed Bayesian network modeling to find the most accurate representation of the complex system of PT/BRI and identify key variables for understanding the subsequent effects of blast exposure in a sample of Florida National Guard members (1,443 deployed to Operation Enduring Freedom/Operation Iraqi Freedom and 1,655 not deployed) who completed an online survey during the period from 2009 to 2010...
January 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27931783/reduced-p3b-brain-response-during-sustained-visual-attention-is-associated-with-remote-blast-mtbi-and-current-ptsd-in-u-s-military-veterans
#16
Casey S Gilmore, Craig A Marquardt, Seung Suk Kang, Scott R Sponheim
Approximately 275,000 American service members deployed to Iraq or Afghanistan have sustained a mild traumatic brain injury (mTBI), with 75% of these incidents involving an explosive blast. Combat-related mTBI is frequently associated with comorbid mental health disorders, especially posttraumatic stress disorder (PTSD). Attention problems, including sustained attention, are common cognitive complaints of veterans with TBI and PTSD. The present study sought to examine neural correlates of sustained attention in veterans with blast mTBI and/or current PTSD...
December 5, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27903275/cell-cycle-inhibition-reduces-inflammatory-responses-neuronal-loss-and-cognitive-deficits-induced-by-hypobaria-exposure-following-traumatic-brain-injury
#17
Jacob W Skovira, Junfang Wu, Jessica J Matyas, Alok Kumar, Marie Hanscom, Shruti V Kabadi, Raymond Fang, Alan I Faden
BACKGROUND: Traumatic brain injury (TBI) patients in military settings can be exposed to prolonged periods of hypobaria (HB) during aeromedical evacuation. Hypobaric exposure, even with supplemental oxygen to prevent hypoxia, worsens outcome after experimental TBI, in part by increasing neuroinflammation. Cell cycle activation (CCA) after TBI has been implicated as a mechanism contributing to both post-traumatic cell death and neuroinflammation. Here, we examined whether hypobaric exposure in rats subjected to TBI increases CCA and microglial activation in the brain, as compared to TBI alone, and to evaluate the ability of a cyclin-dependent kinase (CDK) inhibitor (CR8) to reduce such changes and improve behavioral outcomes...
December 1, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27901414/cognitive-deficits-and-inflammatory-response-resulting-from-mild-to-moderate-traumatic-brain-injury-in-rats-are-exacerbated-by-repeated-pre-exposure-to-an-innate-stress-stimulus
#18
Michaël Ogier, Amor Belmeguenai, Thomas Lieutaud, Béatrice Georges, Sandrine Bouvard, Emilie Carré, Frédéric Canini, Laurent Bezin
Traumatic brain injury (TBI) is common in both military and civilian populations, and often results in neurobehavioral sequelae that impair quality of life in both patients and their families. Although individuals who are chronically exposed to stress are more likely to experience TBI, it is still unknown whether pre-injury stress influences the outcome after TBI. The present study tested whether behavioral and cognitive long-term outcome after TBI in rats is affected by prior exposure to an innate stress stimulus...
January 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27863701/the-many-wounds-of-war-the-association-of-service-related-and-clinical-characteristics-with-problems-with-the-law-in-iraq-and-afghanistan-veterans
#19
Autumn Backhaus, Shadi Gholizadeh, Kathryn M Godfrey, James Pittman, Niloofar Afari
Previous research has demonstrated that veterans with posttraumatic stress disorder (PTSD) are at higher risk for aggression, hostility, and anger, potentially leading to problems with the law or disciplinary action while in the military. There have been calls for increased consideration of the unique aspects of the judicial system in legal matters with veterans involved. The bulk of the research so far has considered the link between PTSD, traumatic brain injury (TBI), and combat exposure, but little is known about the potential role of chronic pain and Military Sexual Trauma (MST) in a veteran's experience of anger, aggression, and discipline while in the military and legal concerns...
November 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/27834544/active-duty-service-members-who-sustain-a-traumatic-brain-injury-have-chronically-elevated-peripheral-concentrations-of-a%C3%AE-40-and-lower-ratios-of-a%C3%AE-42-40
#20
Natasha Lejbman, Anlys Olivera, Morgan Heinzelmann, Rebekah Feng, Sijung Yun, Hyung-Suk Kim, Jessica Gill
PRIMARY OBJECTIVE: Excessive accumulation of amyloid beta (Aβ) and tau have been observed in older individuals with chronic neurological symptoms related to a traumatic brain injury (TBI), yet little is known about the possible role of Aβ in younger active duty service members following a TBI. The purpose of the study was to determine if Aβ 40 or 42 related to sustaining a TBI or to chronic neurological symptoms in a young cohort of military personnel. RESEARCH DESIGN: This was a cross-sectional study of active duty service members who reported sustaining a TBI and provided self-report of neurological and psychological symptoms and provided blood...
2016: Brain Injury: [BI]
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