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https://www.readbyqxmd.com/read/27908422/toenail-mercury-and-dyslipidemia-interaction-with-selenium
#1
Kyong Park, Eunmin Seo
BACKGROUND: Although compelling evidences from in vivo and in vitro studies exist, limited studies have examined the association between chronic mercury exposure and dyslipidemia. Particularly, data are sparse regarding the influence of selenium on this association of mercury with dyslipidemia in humans. PURPOSE: The purpose of the current study was to examine the associations of toenail mercury with dyslipidemia and its components, and to examine whether selenium in toenails modifies these associations...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27906614/development-of-new-forms-of-self-injurious-behavior-following-total-dental-extraction-in-lesch-nyhan-disease
#2
Livia Gisbert de la Cuadra, Rosa J Torres, Luis M Beltrán, Arantxa Sánchez, Juan G Puig
We report two Lesch-Nyhan Disease (LND) patients who developed new forms of self-injurious behavior following total dental extraction. Patients 1 and 2 were submitted to total teeth extraction at the age of 13 and 8 years, respectively, due to continuous self-biting, not prevented by mouth guards. Severity of dystonia was markedly reduced and quality of life improved. After 12 and 17 months, respectively, patient 1 started rubbing one foot against other and scratching toenails with his hands, and patient 2 stuck his legs and feet against hard objects...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27876085/onychomycosis-in-diabetic-patients-in-fako-division-of-cameroon-prevalence-causative-agents-associated-factors-and-antifungal-sensitivity-patterns
#3
Marvlyn Eba, Anna Longdoh Njunda, Rene Njikam Mouliom, Emmanuel Tebit Kwenti, Anold Nsoh Fuh, Gordon Takop Nchanji, Julius Atashili
BACKGROUND: Onychomycosis is an infection of the nail unit by a fungus. This is a very common infection amongst diabetics. Its occurrence among diabetics in Fako division is unknown. In this study we provide information on the characteristics of onychomycosis in diabetics in Fako division, Cameroon. METHODS: A cross-sectional descriptive and analytical hospital-based study was conducted in two diabetic clinics in the Buea and Limbe regional hospitals. We recruited 152 consenting diabetics into the study...
November 22, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27873356/nail-psoriasis-a-systematic-evaluation-in-313-children-with-psoriasis
#4
Diane Pourchot, Christine Bodemer, Alice Phan, Anne-Claire Bursztejn, Smaïl Hadj-Rabia, Franck Boralevi, Juliette Miquel, Thomas Hubiche, Eve Puzenat, Anne-Laure Souillet, Ingrid Kupfer, Maryam Piram, Alain Beauchet, Emmanuel Mahé
BACKGROUND/OBJECTIVES: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis. METHODS: We performed a multicenter, cross-sectional study in 23 French dermatology centers. All children seen during the 1-year study were systematically included...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27856773/real-world-efficacy-of-1064-nm-nd-yag-laser-for-the-treatment-of-onychomycosis
#5
REVIEW
Jason K Rivers, Brianne J Vestvik, Jonathan Berkowitz
BACKGROUND: Onychomycosis is a cosmetic and, at times, medical concern; therefore, effective and safe alternatives to treatment are needed. OBJECTIVE: To determine the efficacy of a 1064-nm Nd:YAG laser for the treatment of onychomycosis in a real-world setting. METHODS: A single-centre retrospective chart review was conducted between 2012 and 2013. One hundred consecutive patients with a culture- and/or potassium hydroxide-confirmed diagnosis of onychomycosis were treated at least twice...
November 16, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27852988/clinical-characteristics-of-acquired-ungual-fibrokeratoma
#6
Sewon Hwang, Miri Kim, Baik Kee Cho, Hyun Jeong Park
BACKGROUND: Acquired ungual fibrokeratomas are uncommon fibrous tissue tumors located in the ungual area. Though there are many reports of this entity, only some reports have reviewed the clinical features of the tumor. AIMS: The aim of this study was to clarify the clinical characteristics of acquired ungual fibrokeratomas. METHODS: We reviewed twenty patients who were treated surgically at our clinic from 2003 to 2014 for acquired ungual fibrokeratomas confirmed on histopathological examination...
November 11, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27843933/onychomycosis-practical-approaches-to-minimize-relapse-and-recurrence
#7
REVIEW
Antonella Tosti, Boni E Elewski
INTRODUCTION: Toenail onychomycosis is a common disease in which treatment options are limited and treatment failures and disease recurrence are frequently encountered. It usually requires many months of treatment, and recurrence may occur in more than half of the patients within 1 year or more after the infection has been eradicated. Data on long-term treatment, follow-up and recurrence are limited. OBJECTIVE: Our objective is to interpret these data and recommend practical approaches that should minimize recurrence based on our clinical experience...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27826474/analysis-of-the-survival-of-arterialized-venous-toenail-flap-with-reference-to-changes-in-blood-circulation-during-the-postoperative-period-in-2-patients
#8
Naohiro Ishii, Yusuke Shimizu, Marie Aoki, Ayaka Suzuki, Kazuo Kishi
Various techniques for nail reconstruction have been reported until now; however, a simple one providing good esthetic results was difficult to find. Arterialized venous toenail flap is a free flap that includes the nail bed and matrix with a pedicle formed solely by the subcutaneous vein of the toe. The use of this flap is minimally invasive and easy, and the flap has a high survival rate. The mechanism of graft survival remains unknown given the nonphysiologic circulation. To the best of our knowledge, no studies have explained this mechanism with reference to detailed postoperative course...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27825389/maternal-arsenic-exposure-and-gestational-diabetes-and-glucose-intolerance-in-the-new-hampshire-birth-cohort-study
#9
Shohreh F Farzan, Anala Gossai, Yu Chen, Lisa Chasan-Taber, Emily Baker, Margaret Karagas
BACKGROUND: Gestational diabetes mellitus (GDM) is a major pregnancy complication with detrimental effects for both mothers and their children. Accumulating evidence has suggested a potential role for arsenic (As) exposure in the development of GDM, but current studies have not assessed As exposure from water, urine or toenail samples. METHODS: We investigated the association between As exposure and risk of glucose intolerance and GDM among 1151 women enrolled in the New Hampshire Birth Cohort Study...
November 8, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27825175/update-on-efinaconazole-10-topical-solution-for-the-treatment-of-onychomycosis
#10
A K Gupta, C Studholme
Efinaconazole 10% nail solution is a novel topical antifungal drug for the treatment of onychomycosis. Two Phase III trials were completed using efinaconazole 10% nail solution, where 17.8% and 15.2% of patients achieved complete cure, and 55.2% and 53.4% achieved mycological cure. Several post hoc analyses were carried out using data from Phase III trials to determine the efficacy of efinaconazole with respect to disease duration, disease progression, and comorbidities of diabetes or tinea pedis with onychomycosis...
November 2016: Skin Therapy Letter
https://www.readbyqxmd.com/read/27824223/onychomycosis-by-paecilomyces-lilacinus
#11
Paolo Pontini, Alberto Gorani, Stefano Veraldi
The authors describe a case of onychomycosis by Paecilomyces lilacinus in an 81-year-old Caucasian woman. The infection was characterized clinically by yellow-brown discoloration of the nail plate, distal-lateral onycholysis and subungual hyperkeratosis of the first left toenail. Microscopic examination showed irregular hyphae. Four cultures showed the development of lilac and powdery colonies. Conidiophores with divergent long narrow terminal phialides were observed at microscopic examination of culture samples...
December 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27821220/outdoor-stocking-density-in-free-range-laying-hens-effects-on-behaviour-and-welfare
#12
D L M Campbell, G N Hinch, J A Downing, C Lee
Free-range laying hen systems are increasing within Australia and research is needed to determine optimal outdoor stocking densities. Six small (n=150 hens) experimental flocks of ISA Brown laying hens were housed with access to ranges simulating one of three outdoor stocking densities with two pen replicates per density: 2000 hens/ha, 10 000 hens/ha or 20 000 hens/ha. Birds were provided daily range access from 21 to 36 weeks of age and the range usage of 50% of hens was tracked using radio-frequency identification technology...
November 8, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27817781/-a-gene-study-of-a-family-with-hidrotic-ectodermal-dysplasia
#13
Wen-Xing Qiao, Li Liu
OBJECTIVE: To investigate the clinical features and molecular mechanism of hidrotic ectodermal dysplasia (HED). METHODS: A clinical and gene study was performed for five generations (91 people) in the family of one proband with HED. GJB6 gene detection was performed for 7 patients and 3 normal people in this family. RESULTS: Among the 91 people in this family, there were 17 HED patients, who were manifested as having dysplasia of the fingernails and toenails and sparse or absent hair or body hair...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27810017/toenail-paronychia
#14
REVIEW
Adam Lomax, James Thornton, Dishan Singh
Paronychia is an inflammation of the tissues alongside the nail. It may be acute or chronic and can be seen in isolation or in association with an ingrowing toenail. Acute paronychial infections develop when a disruption occurs between the seal of the nail fold and the nail plate, providing a portal of entry for invading organisms. The treatment of paronychia associated with an ingrowing toenail is aimed at treating the causal toenail. In paronychia not associated with an ingrowing toenail, antibiotics may cure an early infection but surgical drainage of an abscess is often required...
December 2016: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27741506/clinical-and-genomic-evaluation-of-a-chinese-patient-with-a-novel-deletion-associated-with-phelan-mcdermid-syndrome
#15
Dongzhu Lei, Shaoyuan Li, Santasree Banerjee, Haoqing Zhang, Caiyun Li, Shuai Hou, Danjing Chen, Haiying Yan, Hanmei Li, Huan Huan Peng, Saijun Liu, Xinxin Zhang, Zhiyu Peng, Jian Wang, Huanming Yang, Hui Huang, Jing Wu
Phelan-McDermid syndrome is a neurodevelopmental disorder caused by the terminal deletion of chromosome 22 (22q13) followed by the loss of function of the SHANK3 gene. Various terminal deletions of chromosome 22q13 are associated with Phelan-McDermid with a spectrum of phenotypic severity. Here, we have done a clinical molecular study of a Chinese proband with Phelan-McDermid syndrome. Both the proband and her younger brother are associated with this syndrome while their parents are phenotypically normal. We used a karyotype in order to detect the genotype of the proband and her younger brother...
October 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27741345/topical-treatment-of-onychomycosis-and-clinically-meaningful-outcomes
#16
Aditya K Gupta, Andrew Korotzer
BACKGROUND: Although a completely normal nail would be the ideal outcome when treating onychomycosis, this is not always achievable and long treatment courses or patient expectations can impact patient adherence. METHODS: We analyzed cure rates from a number of subpopulations derived from the two pivotal phase III studies with efinaconazole topical solution (10%) to provide some insights into clinically meaningful treatment outcomes and support for effective long-term management programs...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27734499/onychocryptosis-a-long-term-retrospective-and-comparative-follow-up-study-of-surgical-and-phenol-chemical-matricectomy-in-520-procedures
#17
David Romero-Pérez, Isabel Betlloch-Mas, Belén Encabo-Durán
BACKGROUND: Onychocryptosis or ingrown toenail is a common condition for which there are several treatment options. Surgical matricectomy (SM) is the classical procedure, whereas chemical matricectomy with phenol (CMP) is the most widely used nowadays. OBJECTIVES: This study was designed to evaluate the success rate, postoperative comfort, postoperative complications, and patient satisfaction provided by each of these procedures. METHODS: A retrospective study of all patients who underwent surgery for ingrown toenail over a 5-year period was performed...
October 12, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27703019/chemical-and-physical-strategies-in-onychomycosis-topical-treatment-a-review
#18
Tamara Angelo, Lívia Neves Borgheti-Cardoso, Guilherme Martins Gelfuso, Stephânia Fleury Taveira, Tais Gratieri
Onychomycosis is a fungal infection of the fingernails or toenails caused by dermatophytes, nondermatophytes, moulds, and yeasts. This condition affects around 10-30% people worldwide, negatively influencing patients' quality of life, with severe outcomes in some cases. Since the nail unit acts as a barrier to exogenous substances, its physiological features hampers drug penetration, turning the onychomycosis treatment a challenge. Currently, there are several oral and topical therapies available; nevertheless, cure rates are still low and relapse rates achieves 10-53%...
October 4, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27699147/onychomycosis-due-to-chaetomium-globosum-with-yellowish-black-discoloration-and-periungual-inflammation
#19
Dongmei Shi, Guixia Lu, Huan Mei, G Sybren de Hoog, Hailin Zheng, Guanzhao Liang, Yongnian Shen, Tianhang Li, Weida Liu
Onychomycosis is usually caused by dermatophytes, although also other filamentous and yeast-like fungi are associated with nail invasion. Chaetomium is an environmental genus of ascomycetes exhibiting a certain degree of extremotolerance. We report the first case of onychomycosis in a 46-year-old woman in China caused by Chaetomium globosum. The patient showed yellowish black discoloration with periungual inflammation on the left first toenail. We confirmed the causative agent, C. globosum, by KOH mount, culture, micromorphology and DNA sequence analysis...
September 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27693976/cumulative-arsenic-exposure-is-associated-with-fungal-infections-two-cohort-studies-based-on-southwestern-and-northeastern-basins-in-taiwan
#20
Ling-I Hsu, Yu-Wen Cheng, Chien-Jen Chen, Meei-Maan Wu, Kuang-Hung Hsu, Hung-Yi Chiou, Chih-Hung Lee
Long-term arsenic exposure results in atherosclerosis and cancers, along with aberrant immune responses. Animal-based and epidemiological studies indicate that arsenic exposure increases susceptibility to viral and bacterial infections. This study aimed to assess whether arsenic exposure is associated with the development of fungal infection, which is substantially attributed to as a cause of aberrant immunity. Based on two well-established cohorts from two basins in southwestern (SW; high arsenic area) and northeastern (NE; low arsenic area) Taiwan (n=297 and 2738, respectively), the arsenic exposure in well water was estimated using HPLC-ICP-MS...
September 29, 2016: Environment International
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