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https://www.readbyqxmd.com/read/28906086/new-formulation-for-topical-treatment-of-onychomycoses
#1
Elisa M Difonzo, Federica Scarfì, Massimiliano Galeone
BACKGROUND: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28904300/hair-mercury-levels-in-relation-to-fish-consumption-among-vietnamese-in-hanoi
#2
Van Anh Thi Hoang, Hien Thu Thi Do, Tetsuro Agusa, Chihaya Koriyama, Suminori Akiba, Yasuhiro Ishibashi, Mineshi Sakamoto, Megumi Yamamoto
People are exposed to methylmercury (MeHg) mainly through fish consumption, which is increasing in Vietnam. However, little information is available on estimating the health risk of MeHg exposure through fish consumption in Vietnam. The present study examined the association between mercury (Hg) levels in hair and selenium (Se) levels in toenails of 196 Vietnamese people and their fish consumption, using a dietary questionnaire to obtain information pertinent for assessing health risk owing to MeHg exposure...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28901783/quantification-of-manganese-and-mercury-in-toenail-in-vivo-using-portable-x-ray-fluorescence-xrf
#3
Xinxin Zhang, Aaron J Specht, Linda H Nie
BACKGROUND AND OBJECTIVE: Toenail is an advantageous biomarker to assess exposure to metals such as manganese and mercury. Toenail Mn and Hg are in general analyzed by chemical methods such as ICP-MS and AAS. In this project, a practical and convenient technology - portable x-ray florescence (XRF) - is studied for the non-invasive in vivo quantification of manganese and mercury in toenail. MATERIALS AND METHODS: The portable XRF method has advantages in that it does not require toenail clipping and it can be done in 3 minutes, which will greatly benefit human studies involving the assessment of manganese and mercury exposures...
September 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28892761/ethyl-glucuronide-in-keratinous-matrices-as-biomarker-of-alcohol-use-a-correlation-study-between-hair-and-nails
#4
Delphine Cappelle, Hugo Neels, Steven De Keukeleire, Erik Fransen, Geert Dom, Annemie Vermassen, Adrian Covaci, Cleo L Crunelle, Alexander L N van Nuijs
To quantify alcohol use, objective, specific and sensitive long-term alcohol markers are necessary. Ethyl glucuronide (EtG), a direct metabolite of alcohol, accumulates in keratinous matrices such as hair and nails, and is a specific and sensitive long-term biomarker for the detection of chronic alcohol consumption. So far, research has primarily focused on the detection of EtG in hair, and studies on its measurement in nails are scarce. In this article, we assessed EtG concentrations in hair, finger- and toenails from the same individuals in order to evaluate the direct correlation between the matrices...
August 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28880601/onychomycosis-infectionsdo-polymerase-chain-reaction-and-culture-reports-agree
#5
Aditya K Gupta, Kerry-Ann Nakrieko
BACKGROUND: Mycological culture is the traditional method for identifying infecting agents of onychomycosis despite high false-negative results, slower processing, and complications surrounding nondermatophyte mold (NDM) infections. Molecular polymerase chain reaction (PCR) methods are faster and suited for ascertaining NDM infections. METHODS: To measure agreement between culture and PCR methods for identification of infecting species of suspected onychomycosis, single toenail samples from 167 patients and repeated serial samples from 43 patients with suspected onychomycosis were processed by culture and PCR for identification of 16 dermatophytes and five NDMs...
July 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28867366/assessment-of-saliva-hair-and-toenails-as-biomarkers-of-low-level-exposure-to-manganese-from-drinking-water-in-children
#6
Ruth Ntihabose, Céline Surette, Delphine Foucher, Olivier Clarisse, Maryse F Bouchard
We evaluated hair, toenails, and saliva (whole and supernatant) as biomarkers of exposure to manganese (Mn) in 274 school age children (6-13 years) consuming well water in southeastern New Brunswick, Canada. Mn concentrations in tap water ranged from <0.03 to 1046μgL(-1) (geometric mean 5.96μgL(-1)). The geometric mean of Mn intake resulting from the consumption of water was 0.25 (0-34.95) μg kg(-1)day(-1). Both Mn concentration in water and Mn intake were significantly correlated with Mn in hair (r=0...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28860708/onychomadesis-associated-with-chemotherapy-case-report-and-mini-literature-review
#7
Ang Li, Yanqiong Li, Lingzhi Ge, Ping Li, Wenfei Li
The side effects of chemotherapy drugs have increased in recent years, and some side effects can lead to onychomadesis. A 72-year-old woman who was diagnosed with an invasive ductal carcinoma of the right breast underwent a modified radical mastectomy in April 2015, followed by chemotherapy with capecitabine and nanoparticle albumin-bound paclitaxel (nab-paclitaxel). Subsequently, the patient experienced palmoplantar redness, pain, onycholysis, a transparent serous exudate, and onychomadesis. The chemotherapy was discontinued, and the patient was treated with oral vitamin B6, a polymyxin ointment, and a high-energy red light...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28859750/acquired-idiopathic-true-transverse-leukonychia
#8
Ali Hadi, Dana Stern
A 34-year-old man from Djibouti presented with a 14-year history of relapsing and remitting transverse white bands on the fingernails with sparing of the toenails. Examination revealed several transverse, white bands following the contour of the lunula on seven of his fingernails that did not fade upon compression of the digits (Figure). There was no onycholysis. No other skin lesions were noted. The patient reported having lived for 4 years (2000-2004) in a house that had well water as its primary water supply...
2017: Skinmed
https://www.readbyqxmd.com/read/28856784/topical-antifungal-treatment-prevents-recurrence-of-toenail-onychomycosis-following-cure
#9
Avner Shemer, Aditya K Gupta, Adaia Kamshov, Meir Babaev, Renata Farhi, C Ralph Daniel, Kelly A Foley
Recurrence rates are high for onychomycosis, with prophylactic topical antifungal use proposed to counter recurrence. Although this is a reasonable action for many clinicians, few studies have been conducted on the efficacy of topical prophylaxis. A retrospective chart review (2010-2015) was conducted in patients receiving oral terbinafine or itraconazole for toenail onychomycosis. Following complete cure, a topical antifungal (amorolfine, bifonazole, ciclopirox olamine, or terbinafine spray) was used weekly as prophylaxis...
August 30, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28818805/association-between-consumption-of-private-well-water-contaminated-by-low-levels-of-arsenic-and-dysglycemia-in-a-rural-region-of-quebec-canada
#10
Éric Lampron-Goulet, Fabien Gagnon, Marie-France Langlois
The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c - higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada...
August 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28818358/black-toenail-sign-in-melas-syndrome
#11
Matthew T Whitehead, Michael Wien, Bonmyong Lee, Nancy Bass, Andrea Gropman
BACKGROUND: Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome is a mitochondrial disorder often causing progressive brain injury that is not confined to large arterial territories. Severe insults ultimately lead to gyral necrosis affecting the cortex and juxtacortical white matter; the neuroimaging correlate is partial gyral signal suppression on T2/FLAIR sequences that resemble black toenails. We aimed to characterize the imaging features and the natural history of MELAS-related gyral necrosis...
July 12, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28752090/dr-buzby-s-toegrips-%C3%A2-application-results-in-minimal-changes-in-kinetic-gait-parameters-in-normal-dogs
#12
James K Roush, Leslie E Moore, Walter C Renberg
Poor traction on slick surfaces is difficult for dogs with neurologic deficits, osteoarthritis, or recovering from injury or surgery. Many dogs respond inappropriately to slick surfaces by decreasing digital pad-floor contact and extending their toenails. A device marketed to increase paw-floor friction in dogs was evaluated. Fifteen normal dogs underwent kinetic gait analysis before and after application of Dr. Buzby's ToeGrips(®). Ground reaction forces, including vertical peak force (VPF) and impulse for each limb, were measured and compared between pre- and post-application values...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28749415/association-between-toenail-magnesium-and-type-2-diabetes-in-chinese-adults
#13
Jiguo Zhang, Huijun Wang, Zhihong Wang, Ji Zhang, Bing Zhang
Previous studies have showed an inverse association between magnesium level and type 2 diabetes, but the results are inconsistent, and the evidence relates only to dietary and serum magnesium. Moreover, it is not certain how these findings are applicable to Asian people. This study was designed to examine the association between toenail magnesium and type 2 diabetes in Chinese adults. The sample was 5683 adults aged 18 years or older from the 2009 China Health and Nutrition Survey. We used hemoglobin A1c equal to or greater than 6...
July 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28710932/measurement-of-239-pu-in-keratinous-materials-a-potential-non-invasive-bioassay-for-monitoring-human-exposure
#14
John W N Brown, John D Brockman, J David Robertson
The use of hair, toenail, and fingernail as non-invasive monitors of occupational and environmental exposure to (239)Pu are reported. Volunteers from US national laboratories and individuals with suspected environmental exposure to Pu were recruited to participate in the study. The exposure history of cases was assessed using a short questionnaire. Levels of Pu in keratinous materials collected from the exposed individuals were above the limit of detection in 5 of 7 cases with concentrations ranging from 0...
July 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28707751/oral-antifungal-medication-for-toenail-onychomycosis
#15
REVIEW
Sanne Kreijkamp-Kaspers, Kate Hawke, Linda Guo, George Kerin, Sally Em Bell-Syer, Parker Magin, Sophie V Bell-Syer, Mieke L van Driel
BACKGROUND: Fungal infection of the toenails, also called onychomycosis, is a common problem that causes damage to the nail's structure and physical appearance. For those severely affected, it can interfere with normal daily activities. Treatment is taken orally or applied topically; however, traditionally topical treatments have low success rates due to the nail's physical properties. Oral treatments also appear to have shorter treatment times and better cure rates. Our review will assist those needing to make an evidence-based choice for treatment...
July 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28706389/current-mycological-profile-of-onychomycosis-in-kashmir-valley-a-hospital-based-study
#16
Nazir Asifa, Kanth Farhath
INTRODUCTION: Onychomycosis is a common nail ailment associated with significant physical and psychological morbidity. It is caused by dermatophytes, nondermatophytic molds, and yeasts. Increased prevalence in the recent years is attributed to enhanced longevity, comorbid conditions such as diabetes, avid sports participation, and emergence of HIV. AIMS AND OBJECTIVES: This study was undertaken to identify the mycological profile and etiological agents associated with this infection...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28681095/nail-patella-syndrome
#17
REVIEW
Ralph Witzgall
The pathognomonic symptoms of patients with nail-patella syndrome are their small or absent patellae and dysplastic or absent finger- and toenails. Many of the patients suffer from renal symptoms which also affect their prognosis. In 1998, mutations in the gene encoding the transcription factor LMX1B were identified as underlying this autosomal-dominant disease. The LMX1B gene is expressed in a variety of tissues, and the symptoms are reflected nicely by its expression pattern. LMX1B is essential for dorso-ventral pattern formation in the limbs, for differentiation of the anterior portions of the eyes, for development of certain neuron populations in the central nervous system, and for the differentiation and maintenance of podocytes...
August 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28681027/epidemiological-survey-of-dermatophytosis-in-damascus-syria-from-2008-to-2016
#18
M T Ismail, A Al-Kafri
BACKGROUND AND PURPOSE: It is important to follow annually the probable changes in distribution pattern of dermatophytosis and its etiological agents in different communities. In this study, we determined the prevalence of dermatophytosis and its causative agents in Damascus, Syria, between 2008 and 2016. MATERIALS AND METHODS: A total of 4080 outpatients who visited the dermatological clinics in Damascus, were evaluated. The specimens were collected from clinically suspected tinea...
September 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28678089/children-receiving-hematopoietic-stem-cell-transplantation-are-at-increased-risk-of-onychocryptosis-requiring-surgical-management
#19
Brian Ezekian, Brian R Englum, Brian F Gilmore, Jina Kim, Harold J Leraas, Timothy A Driscoll, Elisabeth T Tracy, Henry E Rice
PURPOSE: At our institution, a high proportion of children with onychocryptosis (ingrown toenail) requiring surgical intervention were noted to have a history of hematopoietic stem cell transplantation (HSCT). We analyzed the characteristics of patients who underwent surgical intervention for onychocryptosis and examined our institutional HSCT database to determine if an association exists between onychocryptosis and HSCT. MATERIALS AND METHODS: Surgical cases for onychocryptosis performed from 2000 to 2012 were identified...
July 3, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28670355/a-retrospective-study-of-non-thermal-laser-therapy-for-the-treatment-of-toenail-onychomycosis
#20
Kerry Zang, Robert Sullivan, Steven Shanks
Objective: The objective of this study was to assess the efficacy of non-thermal laser therapy for treating toenail onychomycosis. Design: This retrospective study analyzed the results of three nonrandomized, open-label studies. The device used was a 635nm/405nm dual-diode laser. Affected toenails were treated for 12 minutes weekly for 2 or 4 weeks. Setting: Treatments occurred in clinic and private office settings. Participants: Subjects with onychomycosis-infected toenails were enrolled. Measurements: Fifty great toenails were included in the analysis based on visually identifiable onychomycosis; thickened, discolored nail plate; and confirmed etiology of onychomycosis...
May 2017: Journal of Clinical and Aesthetic Dermatology
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