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Dongzhu Lei, Shaoyuan Li, Santasree Banerjee, Haoqing Zhang, Caiyun Li, Shuai Hou, Danjing Chen, Haiying Yan, Hanmei Li, Huan Huan Peng, Saijun Liu, Xinxin Zhang, Zhiyu Peng, Jian Wang, Huanming Yang, Hui Huang, Jing Wu
Phelan-McDermid syndrome is a neurodevelopmental disorder caused by the terminal deletion of chromosome 22 (22q13) followed by the loss of function of the SHANK3 gene. Various terminal deletions of chromosome 22q13 are associated with Phelan-McDermid with a spectrum of phenotypic severity. Here, we have done a clinical molecular study of a Chinese proband with Phelan-McDermid syndrome. Both the proband and her younger brother are associated with this syndrome while their parents are phenotypically normal. We used a karyotype in order to detect the genotype of the proband and her younger brother...
October 10, 2016: Oncotarget
Aditya K Gupta, Andrew Korotzer
BACKGROUND: Although a completely normal nail would be the ideal outcome when treating onychomycosis, this is not always achievable and long treatment courses or patient expectations can impact patient adherence. METHODS: We analyzed cure rates from a number of subpopulations derived from the two pivotal phase III studies with efinaconazole topical solution (10%) to provide some insights into clinically meaningful treatment outcomes and support for effective long-term management programs...
October 1, 2016: Journal of Drugs in Dermatology: JDD
David Romero-Pérez, Isabel Betlloch-Mas, Belén Encabo-Durán
BACKGROUND: Onychocryptosis or ingrown toenail is a common condition for which there are several treatment options. Surgical matricectomy (SM) is the classical procedure, whereas chemical matricectomy with phenol (CMP) is the most widely used nowadays. OBJECTIVES: This study was designed to evaluate the success rate, postoperative comfort, postoperative complications, and patient satisfaction provided by each of these procedures. METHODS: A retrospective study of all patients who underwent surgery for ingrown toenail over a 5-year period was performed...
October 12, 2016: International Journal of Dermatology
Tamara Angelo, Lívia Neves Borgheti-Cardoso, Guilherme Martins Gelfuso, Stephânia Fleury Taveira, Tais Gratieri
Onychomycosis is a fungal infection of the fingernails or toenails caused by dermatophytes, nondermatophytes, moulds, and yeasts. This condition affects around 10-30% people worldwide, negatively influencing patients' quality of life, with severe outcomes in some cases. Since the nail unit acts as a barrier to exogenous substances, its physiological features hampers drug penetration, turning the onychomycosis treatment a challenge. Currently, there are several oral and topical therapies available; nevertheless, cure rates are still low and relapse rates achieves 10-53%...
October 4, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Dongmei Shi, Guixia Lu, Huan Mei, G Sybren de Hoog, Hailin Zheng, Guanzhao Liang, Yongnian Shen, Tianhang Li, Weida Liu
Onychomycosis is usually caused by dermatophytes, although also other filamentous and yeast-like fungi are associated with nail invasion. Chaetomium is an environmental genus of ascomycetes exhibiting a certain degree of extremotolerance. We report the first case of onychomycosis in a 46-year-old woman in China caused by Chaetomium globosum. The patient showed yellowish black discoloration with periungual inflammation on the left first toenail. We confirmed the causative agent, C. globosum, by KOH mount, culture, micromorphology and DNA sequence analysis...
September 2016: Medical Mycology Case Reports
Ling-I Hsu, Yu-Wen Cheng, Chien-Jen Chen, Meei-Maan Wu, Kuang-Hung Hsu, Hung-Yi Chiou, Chih-Hung Lee
Long-term arsenic exposure results in atherosclerosis and cancers, along with aberrant immune responses. Animal-based and epidemiological studies indicate that arsenic exposure increases susceptibility to viral and bacterial infections. This study aimed to assess whether arsenic exposure is associated with the development of fungal infection, which is substantially attributed to as a cause of aberrant immunity. Based on two well-established cohorts from two basins in southwestern (SW; high arsenic area) and northeastern (NE; low arsenic area) Taiwan (n=297 and 2738, respectively), the arsenic exposure in well water was estimated using HPLC-ICP-MS...
September 29, 2016: Environment International
Aditya K Gupta, Kelly A Foley, Deanne Daigle
BACKGROUND: Despite the fact that lasers are presently indicated for the cosmetic outcome "temporary increase in clear nail", these devices are increasingly used to treat onychomycosis and particularly in patients who are unwilling or unable to take oral antifungal medication. The US Food and Drug Administration (FDA) recently issued draft guidance for medical device trials for onychomycosis. OBJECTIVE: This review evaluates the quality of laser trials for onychomycosis and compares the design guidelines for medical devices and antifungal drugs...
August 10, 2016: Journal of Dermatological Treatment
Ivette A G Deckers, Piet A van den Brandt, Manon van Engeland, Frederik J van Schooten, Roger W L Godschalk, András P Keszei, Janneke G F Hogervorst, Leo J Schouten
We investigated the ion transport mechanism (ITM) in renal cell cancer (RCC) etiology using gene-environment interactions between candidate single nucleotide polymorphisms (SNPs) and associated environmental factors, including dietary intakes of sodium, potassium and fluid, hypertension and diuretic medication. A literature-based selection of 13 SNPs in ten ITM genes were successfully genotyped in toenail DNA of 3,048 subcohort members and 419 RCC cases from the Netherlands Cohort Study. Diet and lifestyle were measured with baseline questionnaires...
September 30, 2016: Scientific Reports
James Q Del Rosso
Topical antifungal management of toenail onychomycosis has been fraught with several therapeutic challenges including difficulty gaining access to the site of infection and the need for prolonged durations of therapy. In addition, there has been a marked lack of information on the impact of toenail polish application on drug penetration after application. This article reviews available data from studies evaluating the effect of nail polish on antifungal drag penetration using ex vivo laboratory models with cadaver fingernail plates with both tavaborole 5% solution and efinaconazole 10% solution...
August 2016: Journal of Clinical and Aesthetic Dermatology
Yasemin Oz, Iman Qoraan, Ali Oz, Ilknur Balta
BACKGROUND: Diabetes patients are particularly susceptible to fungal infections because their vascular and immunological systems are compromised. OBJECTIVES: The present study aimed to determine prevalences of tinea pedis and onychomycosis, factors predisposing to their development, and antifungal susceptibilities of causative fungal species against fluconazole, itraconazole, and terbinafine in patients with type 2 diabetes mellitus (DM). METHODS: Study groups were defined according to hemoglobin A1C rates of ≥6...
September 26, 2016: International Journal of Dermatology
W P Silva-Rocha, M F de Azevedo, G M Chaves
OBJECTIVE: Dermatomycoses are superficial fungal infections which affect the skin, hair and nails of humans and animals. Male and female patients of all ages are affected by this condition. The main etiological agents of dermatomycoses are the dermatophytes fungi of the genera Trichophyton, Microsporum and Epidermophyton, while the main yeasts belong to the genera Candida, Malassezia and Trichosporon. The variation in the distribution of dermatomycoses worldwide justify the conduction of epidemiological studies in order to contribute for the better understanding of patterns of mycological cutaneous infections...
September 20, 2016: Journal de Mycologie Médicale
Marie Chinazzo, Gérard Lorette, Robert Baran, Antoine Finon, Élie Saliba, Annabel Maruani
INTRODUCTION: The anatomy and embryology of the nail are well known, and nail abnormalities are a feature of many genodermatoses. However, the physiological aspect is not well described. We aimed to analyse the physiological features of nails in healthy newborns. METHODS: We performed an observational, prospective study at University Hospital Center of Tours between July and October 2015. Newborns were included by a dermatologist assistant during the systematic examination on release of the mother from the hospital...
September 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Colinda C J M Simons, Leo J Schouten, Roger W Godschalk, Manon van Engeland, Piet A van den Brandt, Frederik J van Schooten, Matty P Weijenberg
The energy restriction (ER)-colorectal cancer (CRC) association is inconsistent in literature. To strengthen the biological plausibility of the ER-CRC association, we investigated whether genetic variation in the insulin-like growth factor (IGF) pathway, a putative underlying mechanism, modulated this association in the Netherlands Cohort Study. Participants completed a questionnaire (n = 120,852) and provided toenail clippings for DNA (∼75%) at baseline. Individuals living in a Western city during the Hunger Winter (1944-45) or Western rural versus non-Western area were exposed to (severe) ER at young age...
September 20, 2016: International Journal of Cancer. Journal International du Cancer
Joanna Busquets, Mounica Banala, Carmen Campanelli, Joya Sahu, Jason B Lee
This report highlights a rare case of a woman with horizontal ridging and tenderness of the right great toenail associated with dyspigmentation of 5 years' duration. Histopathology revealed a cystic structure with an epithelial lining mostly reminiscent of an isthmus-catagen cyst admixed with the presence of both an intermittent, focal granular layer and an eosinophilic cuticle surrounding pink, laminated keratin, most consistent with a diagnosis of subungual onycholemmal cyst (SOC). It is a rare and distinctive nail abnormality occurring in the dermis of the nail bed...
August 2016: Cutis; Cutaneous Medicine for the Practitioner
Pooja Chitgopeker, Hillary Johnson-Jahangir
Onychocryptosis, also known as ingrown toenail, is caused by growth of the lateral edge of the nail into the nail fold. This results in inflammation of the invaded tissue. It is a common problem with ~70% of cases occurring in people between the ages of 12-30 years and causes significant discomfort, pain, and restriction in activity [1]. There is no standard treatment for onychocryptosis and numerous methods have been used, from conservative approaches such as proper nail trimming techniques to more invasive surgical procedures...
2016: Dermatology Online Journal
P W Crous, M J Wingfield, D M Richardson, J J Le Roux, D Strasberg, J Edwards, F Roets, V Hubka, P W J Taylor, M Heykoop, M P Martín, G Moreno, D A Sutton, N P Wiederhold, C W Barnes, J R Carlavilla, J Gené, A Giraldo, V Guarnaccia, J Guarro, M Hernández-Restrepo, M Kolařík, J L Manjón, I G Pascoe, E S Popov, M Sandoval-Denis, J H C Woudenberg, K Acharya, A V Alexandrova, P Alvarado, R N Barbosa, I G Baseia, R A Blanchette, T Boekhout, T I Burgess, J F Cano-Lira, A Čmoková, R A Dimitrov, M Yu Dyakov, M Dueñas, A K Dutta, F Esteve-Raventós, A G Fedosova, J Fournier, P Gamboa, D E Gouliamova, T Grebenc, M Groenewald, B Hanse, G E St J Hardy, B W Held, Ž Jurjević, T Kaewgrajang, K P D Latha, L Lombard, J J Luangsa-Ard, P Lysková, N Mallátová, P Manimohan, A N Miller, M Mirabolfathy, O V Morozova, M Obodai, N T Oliveira, M E Ordóñez, E C Otto, S Paloi, S W Peterson, C Phosri, J Roux, W A Salazar, A Sánchez, G A Sarria, H-D Shin, B D B Silva, G A Silva, M Th Smith, C M Souza-Motta, A M Stchigel, M M Stoilova-Disheva, M A Sulzbacher, M T Telleria, C Toapanta, J M Traba, N Valenzuela-Lopez, R Watling, J Z Groenewald
Novel species of fungi described in the present study include the following from Australia: Vermiculariopsiella eucalypti, Mulderomyces natalis (incl. Mulderomyces gen. nov.), Fusicladium paraamoenum, Neotrimmatostroma paraexcentricum, and Pseudophloeospora eucalyptorum on leaves of Eucalyptus spp., Anungitea grevilleae (on leaves of Grevillea sp.), Pyrenochaeta acaciae (on leaves of Acacia sp.), and Brunneocarpos banksiae (incl. Brunneocarpos gen. nov.) on cones of Banksia attenuata. Novel foliicolous taxa from South Africa include Neosulcatispora strelitziae (on Strelitzia nicolai), Colletotrichum ledebouriae (on Ledebouria floridunda), Cylindrosympodioides brabejum (incl...
June 2016: Persoonia
Hiromitsu Noguchi, Masataro Hiruma, Tadahiko Matsumoto, Rui Kano, Hironobu Ihn
The patient was a 73-year-old healthy female farmer who had been treated with terbinafine for 25.5 months by a primary physician. She exhibited a discoloration and thickening of the right big toenail. She had no concomitant paronychia. Direct microscopy revealed chlamydoconidia and hyphae, and periodic acid-Schiff stained nail specimen showed septate hyphae. On the basis of these morphological features and gene analysis, the final diagnosis was ungual hyalohyphomycosis caused by Fusarium proliferatum. Topical application of 10% efinaconazole solution cured the disease in 10 months...
September 8, 2016: Journal of Dermatology
K Diongue, M A Diallo, M Ndiaye, A S Badiane, M C Seck, A Diop, Y D Ndiaye, D Ndiaye
INTRODUCTION: Superficial fungal infections, particularly of the skin, scalp and nails are very common and have been reported worldwide. The most common causative agents of these mycoses are dermatophytes, yeasts and molds. However, these agents vary with time and depend on many factors including the geography. The objective of this study was to identify the causative agents of superficial mycoses diagnosed at the Le Dantec University Hospital in Dakar (Senegal). MATERIAL AND METHODS: The study concerned 1851 outpatients received in the parasitological and mycological laboratory of Le Dantec hospital during the period from January 2011 to December 2015...
August 31, 2016: Journal de Mycologie Médicale
Abraham R Mwesigye, Scott D Young, Elizabeth H Bailey, Susan B Tumwebaze
The mining and processing of copper in Kilembe, Western Uganda, from 1956 to 1982 left over 15 Mt. of tailings containing cupriferous and cobaltiferous pyrite dumped within a mountain river valley. This pilot study was conducted to assess the nature and extent of risk to local populations from metal contamination arising from those mining activities. We determined trace element concentrations in mine tailings, soils, locally cultivated foods, house dust, drinking water and human biomarkers (toenails) using ICP-MS analysis of acid digested samples...
August 26, 2016: Science of the Total Environment
Todd M Everson, David A Armstrong, Brian P Jackson, Benjamin B Green, Margaret R Karagas, Carmen J Marsit
Cadmium (Cd) is a ubiquitous environmental contaminant implicated as a developmental toxicant, yet the underlying mechanisms that confer this toxicity are unknown. Mother-infant pairs from a Rhode Island birth cohort were investigated for the potential effects of maternal Cd exposure on fetal growth, and the possible role of the PCDHAC1 gene on this association. Mothers with higher toenail Cd concentrations were at increased odds of giving birth to an infant that was small for gestational age or with a decreased head circumference...
October 2016: Reproductive Toxicology
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