Christiane Fuchs, Katherine J Stalnaker, Clifton L Dalgard, Gauthaman Sukumar, Daniel Hupalo, Jonathan M Dreyfuss, Hui Pan, Ying Wang, Linh Pham, Xunwei Wu, Ivan Jozic, R Rox Anderson, Sunghun Cho, Jon H Meyerle, Joshua Tam
Wound research has typically been performed without regard for where the wounds are located on the body, despite well-known heterogeneities in physical and biological properties between different skin areas. The skin covering the palms and soles is highly specialized, and plantar ulcers are one of the most challenging and costly wound types to manage. Using primarily the porcine model, we show that plantar skin is molecularly and functionally more distinct from nonplantar skin than previously recognized, with unique gene and protein expression profiles, broad alterations in cellular functions, constitutive activation of many wound-associated phenotypes, and inherently delayed healing...
January 17, 2024: Journal of Investigative Dermatology