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Plantar ulcer

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https://www.readbyqxmd.com/read/29932927/administration-of-a-co-crystal-of-tramadol-and-celecoxib-in-a-1-1-molecular-ratio-produces-synergistic-antinociceptive-effects-in-a-postoperative-pain-model-in-rats
#1
Manuel Merlos, Enrique Portillo-Salido, Alex Brenchat, Bertrand Aubel, Jordi Buxens, Angels Fisas, Xavier Codony, Luz Romero, Daniel Zamanillo, José Miguel Vela
Drug combination for the treatment of pain is common clinical practice. Co-crystal of Tramadol-Celecoxib (CTC) consists of two active pharmaceutical ingredients (APIs), namely the atypical opioid tramadol and the preferential cyclooxygenase-2 inhibitor celecoxib, at a 1:1 molecular ratio. In this study, a non-formulated 'raw' form of CTC administered in suspension (referred to as ctcsusp ) was compared with both tramadol and celecoxib alone in a rat plantar incision postoperative pain model. For comparison, the strong opioids morphine and oxycodone, and a tramadol plus acetaminophen combination at a molecular ratio of 1:17 were also tested...
June 19, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29932753/plantar-pressure-distribution-in-patients-with-diabetic-peripheral-neuropathy-and-a-first-ray-amputation
#2
Iona Borg, Stephen Mizzi, Cynthia Formosa
BACKGROUND: Elevated dynamic plantar pressures are a consistent finding in diabetic patients with peripheral neuropathy, with implications for plantar foot ulceration. This study aimed to investigate whether a first-ray amputation affects plantar pressures and plantar pressure distribution patterns in individuals living with diabetes and peripheral neuropathy. METHODS: A nonexperimental matched-subject design was conducted. Twenty patients living with diabetes and peripheral neuropathy were recruited...
May 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29924227/solitary-plantar-basal-cell-carcinoma
#3
Maura Simonetti Junqueira Bourroul, Ludmila Lopes Trindade, Vanessa Soares do Nascimento, Anderson da Costa Lino Costa, Ubirajara Honorato da Silva
Basal cell carcinoma is the most frequent skin cancer, generally located in hair-bearing, sunlight-exposed areas. Basal cell carcinoma usually occurs on the head and neck, but very rarely on extra-facial locations. We report a case of a 65-year-old woman presenting with a solitary non-healing ulcer on the sole of the right foot for two years. Histopathological examination showed a typical nodular basal cell carcinoma, confirmed by positivity to Ber-EP4 on immunohistochemistry. There was no history of trauma, exposure to noxious agents, basal cell nevus syndrome, or xeroderma pigmentosum...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29906277/can-ultrasound-measures-of-intrinsic-foot-muscles-and-plantar-soft-tissues-predict-future-diabetes-related-foot-disease-a-systematic-review
#4
Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
https://www.readbyqxmd.com/read/29890399/effect-of-different-casting-design-characteristics-on-offloading-the-diabetic-foot
#5
Manon Westra, Jaap J van Netten, Hendrik A Manning, Jeff G van Baal, Sicco A Bus
BACKGROUND: Non-removable knee-high devices, such as a total contact cast (TCC), are recommended for offloading diabetic plantar forefoot ulcers. However, it is insufficiently known how each of the different design characteristics of these devices contribute to offloading the diabetic foot. RESEARCH QUESTION: What is the offloading effect of the different design characteristics that make up a non-removable knee-high cast for people with diabetes and active or previous plantar forefoot ulcers? METHODS: Sixteen persons with diabetes, peripheral neuropathy and a healed or active plantar forefoot ulcer had their plantar pressures measured during walking in a non-removable knee-high device (TCC), in that device made removable (BTCC), in that device made below-ankle (cast shoe), in that cast shoe worn with a different walking sole and in a newly made cast shoe without a custom-moulded foot-device interface...
May 22, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29863794/role-of-anaerobes-in-polymicrobial-communities-and-biofilms-complicating-diabetic-foot-ulcers
#6
Steven L Percival, Matthew Malone, Dieter Mayer, Anne-Marie Salisbury, Gregory Schultz
Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) present a complex pathology for clinicians to manage. This is partly attributed to the multi-factorial nature of the disease, which may include; altered foot architecture leading to excessive plantar pressures and frictional forces peripheral arterial disease and loss of protective sensation. In addition, to the above co-morbid variables, it is understood that a delayed wound healing state may be perpetuated by the presence of microorganisms residing in the wound tissue...
June 4, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29804922/an-innovative-application-of-the-free-vascularized-medial-femoral-condyle-flap-in-the-prevention-of-recurring-neuropathic-ulcer-in-the-diabetic-foot-a-case-report
#7
Martin Grohmann, Stefan Benedikt, Anna Vasilyeva, Heinz Bürger, Abigail Forbes, Michael Valentin Schintler
Despite various therapy options, the prophylactic and symptomatic treatment of recurrent ulcerations in the diabetic foot are still challenging. We report the application of a free vascularized medial femoral condyle flap to prevent the recurrence of pressure ulcer in a patient with diabetic foot syndrome. Our patient had type 2 diabetes and presented with pressure ulcers and osteomyelitis of metatarsal heads 2 and 3 after a great toe amputation. We chose to use a medial femoral condyle flap as a damper in the area of the metatarsal heads because of the relatively young age and good vascularity of our patient...
May 24, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29796321/mistaken-diabetic-ulcers-a-case-of-bilateral-foot-verrucous-carcinoma
#8
Vanessa Di Palma, Jill P Stone, Andrew Schell, Jeffrey C Dawes
Verrucous carcinoma (VC) is a rare, low-grade, and well-differentiated variant of squamous cell carcinoma. These tumors are slow-growing and exophytic and have a negligible incidence of metastasis. Treatment is complete surgical resection, ideally by Mohs micrographic surgery, to ensure adequate clear margins. Cutaneous VC predominantly occurs on the plantar surface of the foot and rarely occurs in multiple sites. This case study describes the fourth reported occurrence of bilateral VC of the feet in a woman with chronic diabetic foot ulcers...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29791638/assessment-of-ulceration-risk-in-diabetic-individuals
#9
Luz Marina Alfonso Dutra, Maria Rita Carvalho Garbi Novaes, Manuela Costa Melo, Danyelle Lorrane Carneiro Veloso, Dayane Leticia Faustino, Leila Maria Sales Sousa
OBJECTIVE: To identify the risk factors for foot ulceration through the tracing of diabetic peripheral neuropathy and peripheral arterial disease in individuals with type I and II diabetes, who were assisted in reference centers of the Federal District, Brazil. METHOD: a cross-sectional and analytical study, with the assessment of 117 individuals in outpatient clinics of the Federal District. Continuous variables were compared through Mann-Whitney test, and categorized variables, through Chi-square test for univariate analysis and Logistics regression test for multivariate analysis...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29786410/percutaneous-deep-venous-arterialization-in-patients-with-critical-limb-ischemia-a-technical-note
#10
Steven Kum, Eline Huizing, Michiel A Schreve, Çagdas Ünlü, Roberto Ferraresi, Lasitha B Samarakoon, Daniel A van den Heuvel
Critical limb ischemia (CLI) is the presentation of end stage peripheral arterial disease and typically presents with rest pain, ulceration and gangrene. The outcome of conservative treatment is poor and often leads to amputations. Arterial revascularization plays an important role in amputation prevention. Unfortunately, a significant percentage of CLI patients cannot be revascularized and subsequently end up with a palliative amputation. This has led to the need and exploration of new treatment options in this no option subgroup of CLI...
May 22, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29784531/comparison-of-pedal-soft-tissue-thickness-between-those-with-and-without-diabetes
#11
Sangho Oh, Junhyung Kim, Jaehoon Choi, Woonhyeok Jeong, Hyukwon Chang, Soyoung Lee
Ulceration is a serious consequence of diabetes that can lead to disability in patients with diabetes. One of the risk factors for ulceration is high foot pressure. The thickness of the pedal soft tissue is important because it has a cushioning effect. Soft tissue atrophy causes elevation in the plantar pressure, which, in turn, causes ischemia. Therefore, we investigated the severity of pedal soft tissue atrophy caused by diabetes and aging. From February 2009 to February 2016, we examined the feet of 261 patients treated in our hospital using magnetic resonance imaging...
May 18, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29782449/does-the-shoe-fit-considerations-for-proper-shoe-fitting
#12
Marie Mantini Blazer, Laura Beth Jamrog, Lauren Lindsay Schnack
It is important to be properly evaluated for shoes to avoid complications. Ill-fitting shoes can lead to pathologies in different populations. The focus of this article is to review the components and function of a basic athletic-type shoe, general shoe-fitting techniques, and selecting appropriate footwear for various populations including those with diabetes, elderly, and females. Poorly fitting shoes can exacerbate structural foot deformities. Unevenly distributed plantar pressures and wear can lead to ulcerations in diabetic populations...
May 2018: Orthopaedic Nursing
https://www.readbyqxmd.com/read/29748781/plantar-blood-flow-response-to-accumulated-pressure-stimulus-in-diabetic-people-with-different-peak-plantar-pressure-a-non-randomized-clinical-trial
#13
Fang Pu, Weiyan Ren, Hongyuan Fu, Xuan Zheng, Min Yang, Yih-Kuen Jan, Yubo Fan
The aim of this study was to investigate the plantar blood flow response to the same accumulated pressure stimulus in diabetic patients with different peak plantar pressure (PPP), which is important for assessing the risk of diabetic foot ulcer. Eleven diabetic subjects with high PPP (PPP ≥ 207 kPa) and 8 diabetic subjects with low PPP (PPP < 207 kPa) were asked to walk naturally on a treadmill so as to induce an accumulated stimulus of 73,000 kPa·s on their first metatarsal head, which was monitored with a sensorized insole...
May 11, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29745908/local-use-of-granulocyte-macrophages-colony-stimulating-factor-in-treatment-of-chronic-diabetic-neuropathic-ulcer-case-review
#14
E Karlafti, Ch Savopoulos, A Hatzitolios, T Didangelos
One of the main causes of amputations in patients with Diabetes Mellitus patients is a chronic diabetic foot ulcer. The authors present a clinical case and discussion of a successful use of Granulocyte-Macrophages Colony Stimulating Factor (GM-CSF) treatment for the promotion of healing of a chronic diabetic foot ulcer. A 65 year-old woman was admitted to the Diabetes Center with complaints of a deep non-healing chronic foot ulcer for the last 18 months. At the examination a 5 cm ulcer on the plantar surface of the right foot was revealed...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29718811/a-total-offloading-foot-brace-for-treatment-of-diabetic-foot-ulcers-results-from-a-halted-randomized-controlled-trial
#15
David J Johnson, Barbara J Saar, Andrew J Shevitz, Ann H Kim, Lori Hammer, Daniel E Kendrick, Pamela Moorehead, Vikram S Kashyap
INTRODUCTION: Foot offloading is the mainstay treatment for plantar diabetic foot ulcers (DFUs). OBJECTIVE: This multicenter, single-blinded, randomized controlled trial evaluates the efficacy of a total offloading foot brace for healing plantar DFUs. MATERIALS AND METHODS: Seventeen patients were randomized to standard therapy (ie, reducing stress and pressure via mechanical offloading) or offloading foot brace. Comparison of plantar pressures was performed using digital pressure sensing films...
April 18, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29705236/comparison-of-the-complication-incidence-in-open-versus-endoscopic-gastrocnemius-recession-a-retrospective-medical-record-review
#16
Richard C Harris, Kristin L Strannigan, Jason Piraino
Gastrocnemius recession is a practical and effective procedure to address gastrocnemius equinus. It has been shown that an equinus deformity can lead to the development of plantar fasciitis, osteoarthritis, and foot ulcerations. The 2 approaches to gastrocnemius recession are open and endoscopic. Both are viable options; however, both also have associated complications. We compared and evaluated the postoperative complications associated with these procedures. The electronic database of our orthopedics division at the University of Florida College of Medicine, Jacksonville, was retrospectively searched to identify all cases of gastrocnemius recession (Current Procedural Terminology [CPT] code 27687), and unlisted arthroscopy (CPT code 29999) from February 2006 to February 2016...
April 25, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29693624/gait-shear-and-plantar-pressure-monitoring-a-non-invasive-ofs-based-solution-for-e-health-architectures
#17
Cátia Tavares, M Fátima Domingues, Anselmo Frizera-Neto, Tiago Leite, Cátia Leitão, Nélia Alberto, Carlos Marques, Ayman Radwan, Eduardo Rocon, Paulo André, Paulo Antunes
In an era of unprecedented progress in sensing technology and communication, health services are now able to closely monitor patients and elderly citizens without jeopardizing their daily routines through health applications on their mobile devices in what is known as e-Health. Within this field, we propose an optical fiber sensor (OFS) based system for the simultaneous monitoring of shear and plantar pressure during gait movement. These parameters are considered to be two key factors in gait analysis that can help in the early diagnosis of multiple anomalies, such as diabetic foot ulcerations or in physical rehabilitation scenarios...
April 25, 2018: Sensors
https://www.readbyqxmd.com/read/29671368/the-efficacy-of-topical-human-amniotic-membrane-mesenchymal-stem-cell-conditioned-medium-hammsc-cm-and-a-mixture-of-topical-hammsc-cm-vitamin-c-and-hammsc-cm-vitamin-e-on-chronic-plantar-ulcers-in-leprosy-a-randomized-control-trial
#18
C R S Prakoeswa, F R Natallya, D Harnindya, A Thohiroh, R N Oktaviyanti, K D Pratiwi, M A Rubianti, B Yogatri, P I Primasari, N Herwanto, M D Alinda, B H Kusumaputra, L Astari, M Y Listiawan, I Agusni, F A Rantam
BACKGROUND: Healing of chronic plantar ulcers in leprosy (CPUL) typically takes a long time due to impaired neurological function, thereby reducing the levels of growth factors and cytokines. Cytokines can be found in metabolite products from amniotic membrane stem cells. Chronic ulcers are frequently characterized by high levels of reactive oxygen species. Vitamin E (α-tocopherol) is widely used in skin lesions, owing to its antioxidant and anti-inflammatory properties. Vitamin C also has antioxidant, anti-inflammatory, and collagen synthesis properties which are useful in wound healing...
May 10, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29666111/decreasing-an-offloading-device-s-size-and-offsetting-its-imposed-limb-length-discrepancy-lead-to-improved-comfort-and-gait
#19
Ryan T Crews, Joseph Candela
OBJECTIVE: Patient adherence is a challenge in offloading diabetic foot ulcers (DFUs) with removable cast walkers (RCWs). The size and weight of an RCW, changes to gait, and imposed limb length discrepancies may all discourage adherence. This study sought to determine whether RCW size and provision of a contralateral limb lift affected users' comfort and gait. RESEARCH DESIGN AND METHODS: Twenty-five individuals at risk for DFUs completed several 20-m walking trials under five footwear conditions: bilateral standardized shoes, a knee-high RCW with shoe with or without an external shoe lift contralaterally, and an ankle-high RCW with shoe with or without an external shoe lift contralaterally...
April 17, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29590230/duration-of-type-2-diabetes-is-a-predictor-of-elevated-plantar-foot-pressure
#20
Brooke Falzon, Cynthia Formosa, Liberato Camilleri, Alfred Gatt
AIMS: Elevated plantar pressure is considered a significant risk factor for ulceration in diabetes mellitus. The aim of this study was to determine whether duration of diabetes could affect plantar pressure in patients with no known significant comorbidity or foot pathology. METHODS: Participants with type 2 diabetes, but without known confounding factors that could alter peak pressure, were matched for age, weight, and gender and categorized into 3 groups of diabetes duration: group 1 (1-5 yr), group 2 (6-10 yr), and group 3 (11-15 yr)...
2018: Review of Diabetic Studies: RDS
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