Minzhi Chen, Minjuan Lu, Xujun Feng, Meijing Wu, Xiaoqing Luo, Ruiqi Xiang, Ren Luo, Hang Wu, Zhonghua Liu, Meichi Wang, Xi Zhou
Polypeptide toxins are major bioactive components found in venomous animals. Many polypeptide toxins can specifically act on targets, such as ion channels and voltage-gated sodium (Nav) channels, in the nervous, muscle, and cardiovascular systems of the recipient to increase defense and predation efficiency. In this study, a novel polypeptide toxin, LmNaTx15, was isolated from the venom of the scorpion Lychas mucronatus, and its activity was analyzed. LmNaTx15 slowed the fast inactivation of Nav1.2, Nav1.3, Nav1...
October 31, 2023: Toxicon: Official Journal of the International Society on Toxinology