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Image fusion radiation therapy

Tae-Kyum Kim, Wonik Cho, Sang Min Youn, Ung-Kyu Chang
INTRODUCTION: Perioperative irradiation is often combined with spine tumor surgery. Radiation is known to be detrimental to healing process of bone fusion. We tried to investigate bone fusion rate in spine tumor surgery cases with perioperative radiation therapy (RT) and to analyze significant factors affecting successful bone fusion. METHODS: Study cohort was 33 patients who underwent spinal tumor resection and bone graft surgery combined with perioperative RT...
November 2016: Journal of Korean Neurosurgical Society
David A Woodrum, Krzysztof R Gorny, Bernadette Greenwood, Lance A Mynderse
Prostate cancer is the most commonly diagnosed noncutaneous cancer and second-leading cause of death in men. Many patients with clinically organ-confined prostate cancer undergo definitive, curative treatment of the whole gland with either radical prostatectomy or radiation therapy. However, many men are reluctant to take the definitive step due to potential morbidity associated with either therapy. A growing interest in active surveillance or focal therapy has emerged as realistic alternatives for many patients...
September 2016: Seminars in Interventional Radiology
Min Zhang, Ligong Nie, Jiayong Zhang
BACKGROUND: Lung cancer with brain metastasis had poor prognosis. Crizotinib had been confirmed to be used in ROS1 (C-ros oncogene 1 receptor tyrosine kinase) rearranged lung adenocarcinoma, but its efficacy in lung cancer with brain metastasis was poor due to the blood brain barrier. In the present study, we reported one case of ROS1 fusion lung adenocarcinoma with symptomatic brain matastasis, who was treated with brain metastases resection, crizotinib, and whole brain radiotherapy plus boost to residual brain metastasis...
August 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Hossein Arabi, Nikolaos Koutsouvelis, Michel Rouzaud, Raymond Miralbell, Habib Zaidi
Magnetic resonance imaging (MRI)-guided attenuation correction (AC) of positron emission tomography (PET) data and/or radiation therapy (RT) treatment planning is challenged by the lack of a direct link between MRI voxel intensities and electron density. Therefore, even if this is not a trivial task, a pseudo-computed tomography (CT) image must be predicted from MRI alone. In this work, we propose a two-step (segmentation and fusion) atlas-based algorithm focusing on bone tissue identification to create a pseudo-CT image from conventional MRI sequences and evaluate its performance against the conventional MRI segmentation technique and a recently proposed multi-atlas approach...
September 7, 2016: Physics in Medicine and Biology
Pete Bridge, Shane Dempsey, Eileen Giles, Sharon Maresse, Giulia McCorkell, Craig Opie, Caroline Wright, Mary-Ann Carmichael
INTRODUCTION: This article presents the results of a single-day census of radiation therapy (RT) treatment and technology use in Australia. The primary aim of the study was to ascertain patterns of RT practice and technology in use across Australia. These data were primarily collated to inform curriculum development of academic programs, thereby ensuring that training is matched to workforce patterns of practice. METHODS: The study design was a census method with all 59 RT centres in Australia being invited to provide quantitative summary data relating to patient case mix and technology use on a randomly selected but common date...
December 2015: Journal of Medical Radiation Sciences
Constantinos Zamboglou, Hans-Christian Rischke, Philipp Tobias Meyer, Sven Knobe, Natalja Volgeova-Neher, Michael Kollefrath, Cordula Annette Jilg, Anca Ligia Grosu, Dimos Baltas, Malte Kroenig
PURPOSE: We present a novel method for treatment of locally recurrent prostate cancer (PCa) following radiation therapy: focal, multimodal image guided high-dose-rate (HDR) brachytherapy. MATERIAL AND METHODS: We treated two patients with recurrent PCa after primary (#1) or adjuvant (#2) external beam radiation therapy. Multiparametric magnetic resonance imaging (mpMRI), choline, positron emission tomography combined with computed tomography (PET/CT), or prostate-specific membrane antigen (PSMA)-PET combined with CT identified a single intraprostatic lesion...
June 2016: Journal of Contemporary Brachytherapy
Yuanshui Zheng, Randall Johnson, Gary Larson
PURPOSE: Failure mode and effects analysis (FMEA) is a widely used tool to evaluate safety or reliability in conventional photon radiation therapy. However, reports about FMEA application in proton therapy are scarce. The purpose of this study is to apply FMEA in safety improvement of proton treatment planning at their center. METHODS: The authors performed an FMEA analysis of their proton therapy treatment planning process using uniform scanning proton beams. The authors identified possible failure modes in various planning processes, including image fusion, contouring, beam arrangement, dose calculation, plan export, documents, billing, and so on...
June 2016: Medical Physics
Edward W Jung, David L Jung, Ehsan H Balagamwala, Lilyana Angelov, John H Suh, Toufik Djemil, Anthony Magnelli, Samuel T Chao
PURPOSE: Chordoma is a radioresistant tumor that presents a therapeutic challenge with spine involvement, as high doses of radiation are needed for local control while limiting dose to the spinal cord. The purpose of this study is to determine the efficacy and safety of single-fraction spine stereotactic body radiation therapy for the treatment of spine chordoma. METHODS: A retrospective review of our institutional database from 2006 to 2013 identified 8 patients (12 cases) with chordoma of the spine who were treated with spine stereotactic body radiation therapy...
June 3, 2016: Technology in Cancer Research & Treatment
Gabriella Cattari, Elena Delmastro, Sara Bresciani, Sergio Gribaudo, Antonella Melano, Flavio Giannelli, Maria Tessa, Renato Chiarlone, Tindaro Scolaro, Marco Krengli, Alessandro Urgesi, Pietro Gabriele
PURPOSE: We focused the attention on radiation therapy practices about the gynecological malignancies in Piedmont, Liguria, and Valle d'Aosta to know the current treatment practice and to improve the quality of care. MATERIAL AND METHODS: We proposed a cognitive survey to evaluate the standard practice patterns for gynecological cancer management, adopted from 2012 to 2014 by radiotherapy (RT) centers with a large amount of gynecological cancer cases. There were three topics: 1...
April 2016: Journal of Contemporary Brachytherapy
Yosuke Tsuruga, Toshiya Kamiyama, Hirofumi Kamachi, Shingo Shimada, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Hideki Yokoo, Akinobu Taketomi
AIM: To evaluate the usefulness of the functional hepatic resection rate (FHRR) calculated using 3D computed tomography (CT)/(99m)Tc-galactosyl-human serum albumin (GSA) single-photon emission computed tomography (SPECT) fusion imaging for surgical decision making. METHODS: We enrolled 57 patients who underwent bi- or trisectionectomy at our institution between October 2013 and March 2015. Of these, 26 patients presented with hepatocellular carcinoma, 12 with hilar cholangiocarcinoma, six with intrahepatic cholangiocarcinoma, four with liver metastasis, and nine with other diseases...
May 7, 2016: World Journal of Gastroenterology: WJG
Caleb R Dulaney, Daniel O Osula, Eddy S Yang, Soroush Rais-Bahrami
Tremendous technological advancements in prostate radiotherapy have decreased treatment toxicity and improved clinical outcomes for men with prostate cancer. While these advances have allowed for significant treatment volume reduction and whole-organ dose escalation, further improvement in prostate radiotherapy has been limited by classic techniques for diagnosis and risk stratification. Developments in prostate imaging, image-guided targeted biopsy, next-generation gene expression profiling, and targeted molecular therapies now provide information to stratify patients and select treatments based on tumor biology...
2016: Prostate Cancer
Faisal Ahmed, Vikren Sarkar, David K Gaffney, Bill Salter, Matthew M Poppe
PURPOSE: To evaluate radiation dose delivered to pelvic lymph nodes, if daily Image Guided Radiation Therapy (IGRT) was implemented with treatment shifts based on the primary site (primary clinical target volume [CTV]). Our secondary goal was to compare dosimetric coverage with patient outcomes. MATERIALS AND METHODS: A total of 10 female patients with gynecologic malignancies were evaluated retrospectively after completion of definitive intensity-modulated radiation therapy (IMRT) to their pelvic lymph nodes and primary tumor site...
2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Judit Kalincsák, Zoltán László, Zsolt Sebestyén, Péter Kovács, Zsolt Horváth, Tamás Dóczi, Mangel László
BACKGROUND AND PURPOSE: Treatment of central nervous system (CNS) tumors has always played an important role in development of radiotherapy techniques. Precise patient immobilisation, non-coplanar field arrangement, conformal treatment, arc therapy, radiosurgery, application of image fusion to radiation planning or re-irradiation were first introduced into clinical routine in the treatment of brain tumors. METHODS: A modern multifunctional radiation instrument, Novalis TX has been installed at the University of Pécs two years ago...
November 30, 2015: Ideggyógyászati Szemle
C K Cramer, S W Yoon, M Reinsvold, K M Joo, H Norris, R C Hood, J D Adamson, R C Klein, D G Kirsch, M Oldham
BACKGROUND: Despite the clinical benefit of whole brain radiotherapy (WBRT), patients and physicians are concerned by the long-term impact on cognitive functioning. Many studies investigating the molecular and cellular impact of WBRT have used rodent models. However, there has not been a rodent protocol comparable to the recently reported Radiation Therapy Oncology Group (RTOG) protocol for WBRT with hippocampal avoidance (HA) which is intended to spare cognitive function. The aim of this study was to develop a hippocampal-sparing WBRT protocol in Wistar rats...
2015: PloS One
Antonio Pierro, Savino Cilla, Vincenzo Picardi, Marica Ferro, Gabriella Macchia, Francesco Deodato, Milly Buwenge, Giuseppina Sallustio, Alessio G Morganti
Craniopharyngiomas (CPs) are rare benign suprasellar tumors. The standard treatment for CP is complete surgical resection or partial resection followed by adjuvant radiotherapy (RT). Adjuvant RT is typically administered at a total dose of 54 Gy with 1.8 Gy/fraction. The current study reported the case of a young patient affected by recurrent craniopharyngioma, who was treated with irradiation subsequent to several surgical resections. Image fusion and intensity-modulated radiation therapy techniques were employed to deliver a high total dose (63 Gy with 2...
October 2015: Oncology Letters
Monzer A Chehab, Waleed Brinjikji, Alexander Copelan, Aradhana M Venkatesan
The interventional radiologist is increasingly called upon to successfully access challenging biopsy and ablation targets, which may be difficult based on poor visualization, small size, or the proximity of vulnerable regional anatomy. Complex therapeutic procedures, including tumor ablation and transarterial oncologic therapies, can be associated with procedural risk, significant procedure time, and measurable radiation time. Navigation tools, including electromagnetic, optical, laser, and robotic guidance systems, as well as image fusion platforms, have the potential to facilitate these complex interventions with the potential to improve lesion targeting, reduce procedure time, and radiation dose, and thus potentially improve patient outcomes...
December 2015: Seminars in Interventional Radiology
Remi M Ajiboye, Scott D Nelson, Arya N Shamie
BACKGROUND: Yolk sac tumors (YST) are malignant neoplasms. They are a subtype of germ cell tumors and typically originate in the gonads although extragonadal origins of such tumors have been described. Yolk sac tumors are commonly found in the gonads of infants and children and are extremely rare in adults. The goal of this case report is to describe the clinical presentation of a rare case of metastatic extragonadal yolk sac tumor originating from the mediastinum and causing an acute conus medullaris syndrome in an adult male...
2015: International Journal of Spine Surgery
Zhaohui Han, John C Bondeson, John H Lewis, Edward G Mannarino, Scott A Friesen, Matthew M Wagar, Tracy A Balboni, Brian M Alexander, Nils D Arvold, David J Sher, Fred L Hacker
PURPOSE: The purposes of this study were (1) to evaluate the initial setup accuracy and intrafraction motion for spine stereotactic body radiation therapy (SBRT) using stereotactic body frames (SBFs) and (2) to validate an in-house-developed SBF using a commercial SBF as a benchmark. METHODS AND MATERIALS: Thirty-two spine SBRT patients (34 sites, 118 fractions) were immobilized with the Elekta and in-house (BHS) SBFs. All patients were set up with the Brainlab ExacTrac system, which includes infrared and stereoscopic kilovoltage x-ray-based positioning...
January 2016: Practical Radiation Oncology
Maroie Barkati, Dany Simard, Daniel Taussky, Guila Delouya
INTRODUCTION: We assessed the inter- and intra-observer variability in contouring the prostate bed for radiation therapy planning using MRI compared with computed tomography (CT). METHODS: We selected 15 patients with prior radical prostatectomy. All had CT and MRI simulation for planning purposes. Image fusions were done between CT and MRI. Three radiation oncologists with several years of experience in treating prostate cancer contoured the prostate bed first on CT and then on MRI...
April 2016: Journal of Medical Imaging and Radiation Oncology
Min Zhu, Chao Liu, Shuangshuang Ren, Zintong Lin, Leiying Miao, Weibin Sun
Gemination or fusion is a rare occurrence in the mandibular posterior teeth. The aim of this article is to describe the problems encountered and the strategy employed in treating such cases. A 34 years old patient came with the complaint of spontaneous and radiating pain in the right mandibular posterior region. The tooth in concern was an anomalous 'double' second mandibular molar diagnosed as having necrotic pulp with chronic apical abscess of endodontic origin. The present case emphasizes the importance of identifying anatomical anomalies during treatment of fused teeth with supernumerary tooth, and the need for the use of advanced imaging modalities like CBCT which is a critical aid in the diagnosis of such cases...
2015: International Journal of Clinical and Experimental Medicine
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