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Christopher M Cielo, Lourdes M DelRosso, Ignacio E Tapia, Sarah N Biggs, Gillian M Nixon, Lisa J Meltzer, Joel Traylor, Ji Young Kim, Carole L Marcus
INTRODUCTION: Little is known about the pediatric population at an increased risk of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD). Polysomnographic data from the Caffeine for Apnea of Prematurity-Sleep (CAPS) study showed a high prevalence of elevated periodic limb movement index (PLMI) in a cohort of ex-preterm children, but the clinical importance of this finding, such as association with RLS, is unknown. We hypothesized that ex-preterm children would have a high prevalence of RLS and PLMD...
February 2017: Sleep Medicine
Juan Lv, Xuefang Hao, Qian Li, Mary Akpanyung, Abdelilah Nejjari, Agnaldo Luis Neve, Xiangkui Ren, Yakai Feng, Changcan Shi, Wencheng Zhang
In this work, a biodegradable star-shaped copolymer poly(lactide-co-3(S)-methyl-morpholine-2,5-dione)6 (Star-(PLMD)6) was synthesized via ring-opening polymerization (ROP), and subsequently a gene carrier Star-PLMD-g-PEI-g-PEG-CREDVW was prepared by grafting polyethyleneimine (PEI), polyethylene glycol (PEG) and targeting peptide REDV onto Star-(PLMD)6. This gene carrier could form stable micelles to condense pEGFP-ZNF580 through electrostatic interaction. The resulting complexes were biocompatible and showed high efficiency in gene delivery...
January 17, 2017: Biomaterials Science
Jamile Marinho Bezerra de Oliveira Moura, Adriana Costa de Souza Martins Câmara, Cassiano Francisco Weege Nonaka, Leão Pereira Pinto, Lélia Batista de Souza
BACKGROUND: Squamous cell carcinoma (SCC) of the oral cavity is a malignant epithelial tumor that most commonly involves the tongue, and mainly affects men between the fifth and seventh decades of life. This study compared the lymphatic vessel density and VEGF-C expression in SCCs of the tongue between young and old patients. METHODS: Thirty-four SCCs of the tongue, 17 diagnosed in young patients (≤40y) and 17 diagnosed in old patients (>50y), were evaluated by immunohistochemistry...
December 2016: Pathology, Research and Practice
Thomas J Dye, Sejal V Jain, Narong Simakajornboon
OBJECTIVES: Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) are thought to center around a genetically mediated sensitivity to iron insufficiency. Previous studies have shown the effectiveness of short-term iron therapy in children with low iron storage. Little is known, however, about long-term iron treatment in children with RLS and PLMD. Therefore, we performed this study to assess the long-term effect of iron therapy in children with RLS and PLMD. METHODS: A retrospective chart review was performed for children who met the following criteria: A) diagnosed as having either RLS or PLMD, B) started on iron supplementation, C) followed up for >2 years in a sleep clinic...
February 12, 2016: Sleep Medicine
Narong Simakajornboon, Thomas J Dye, Arthur S Walters
Recent studies have shown that restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) are common in pediatric population. The diagnostic criteria for Pediatric RLS have recently been updated to simplify and integrate with newly revised adult RLS criteria. Management of RLS and PLMD involves pharmacologic and nonpharmacologic interventions. Children with low iron storage are likely to benefit from iron therapy. Although, there is limited information on pharmacologic therapy, there are emerging literatures showing the effectiveness of dopaminergic medications in the management of RLS and PLMD in children...
September 2015: Sleep Medicine Clinics
Christian Veauthier, Gunnar Gaede, Helena Radbruch, Klaus-Dieter Wernecke, Friedemann Paul
Quality of Life (QoL) is decreased in multiple sclerosis (MS), but studies about the impact of sleep disorders (SD) on health-related quality of Life (HRQoL) are lacking. From our original cohort, a cross-sectional polysomnographic (PSG) study in consecutive MS patients, we retrospectively analysed the previously unpublished data of the Nottingham Health Profile (NHP). Those MS patients suffering from sleep disorders (n = 49) showed significantly lower HRQoL compared to MS patients without sleep disorders (n = 17)...
2015: International Journal of Molecular Sciences
Sheau-Hwa Wong, Beng-Yeong Ng
INTRODUCTION: Chronic insomnia is associated with many physical and psychiatric illnesses, and its underlying aetiology needs to be identified in order to achieve safe and effective treatment. Obstructive sleep apnoea (OSA) and periodic limb movement disorder (PLMD) are common primary sleep disorders that can lead to chronic insomnia. Patients with these conditions are evaluated using polysomnography (PSG). METHODS: The PSG records of 106 patients with chronic insomnia who presented to a multidisciplinary sleep clinic in Singapore over a five-year period were reviewed...
June 2015: Singapore Medical Journal
S Kotterba
Sleep disorders can be diagnosed in approximately 15 % of the population and have been shown to increase with age. The relationship between sleep disorders and neurological disorders, however, is still insufficiently considered in the clinical practice. Sleep disorders can be an early symptom of the disease, such as the presence of rapid eye movement (REM) sleep behavior disorder (RBD) as an early indicator of neurodegeneration. Sleep disorders have also been shown to be a main symptom of various neurological syndromes, such as in restless legs syndrome (RLS), periodic limb movement disorder (PLMD) and narcolepsy...
June 2015: Der Nervenarzt
Maria Gardani, Eleni Morfiri, Allan Thomson, Brian O'Neill, Thomas M McMillan
OBJECTIVE: To explore the presence and types of sleep disorders in chronic patients with severe traumatic brain injury (TBI) undergoing inpatient rehabilitation using formal diagnostic criteria based on the International Classification of Sleep Disorders, 2nd edition. DESIGN: Cross-sectional study. SETTING: Inpatient brain injury rehabilitation units. PARTICIPANTS: Chronic inpatients with severe TBI (N=30) were evaluated during rehabilitation...
September 2015: Archives of Physical Medicine and Rehabilitation
Kirk J Brower
Insomnia in patients with alcohol dependence has increasingly become a target of treatment due to its prevalence, persistence, and associations with relapse and suicidal thoughts, as well as randomized controlled studies demonstrating efficacy with behavior therapies and non-addictive medications. This article focuses on assessing and treating insomnia that persists despite 4 or more weeks of sobriety in alcohol-dependent adults. Selecting among the various options for treatment follows a comprehensive assessment of insomnia and its multifactorial causes...
June 2015: Alcohol
Julie Anja Engelhard Christensen, Poul Jennum, Henriette Koch, Rune Frandsen, Marielle Zoetmulder, Lars Arvastson, Søren Rahn Christensen, Helge Bjarrup Dissing Sorensen
OBJECTIVE: Patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) are at high risk of developing Parkinson's disease (PD). As wake/sleep-regulation is thought to involve neurons located in the brainstem and hypothalamic areas, we hypothesize that the neurodegeneration in iRBD/PD is likely to affect wake/sleep and REM/non-REM (NREM) sleep transitions. METHODS: We determined the frequency of wake/sleep and REM/NREM sleep transitions and the stability of wake (W), REM and NREM sleep as measured by polysomnography (PSG) in 27 patients with PD, 23 patients with iRBD, 25 patients with periodic leg movement disorder (PLMD) and 23 controls...
January 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Christian Veauthier
Sleep disorders are common in patients with multiple sclerosis (MS) and play a crucial role in health and quality of life; however, they are often overlooked. The most important sleep disorders in this context are as follows: insomnia, restless legs syndrome, periodic limb movement disorders, and sleep-related breathing disorders (SRBD). It is unclear if MS-related processes (lesions, brain atrophy) can cause symptomatic forms of sleep apnea. MS-related narcolepsy-like symptoms are described in the literature and, in some cases, have resolved with methylprednisolone pulse therapy...
May 2015: Current Neurology and Neuroscience Reports
Lydia S Dugdale
No abstract text is available yet for this article.
November 2014: Hastings Center Report
Jacob Kempfner, Helge B D Sorensen, Miki Nikolic, Poul Jennum
SUMMARY: Idiopathic rapid-eye-movement (REM) sleep behavior disorder (iRBD) is most likely the earliest sign of Parkinson's Disease (PD) and is characterized by REM sleep without atonia (RSWA) and consequently increased muscle activity. However, some muscle twitching in normal subjects occurs during REM sleep. PURPOSE: There are no generally accepted methods for evaluation of this activity and a normal range has not been established. Consequently, there is a need for objective criteria...
October 2014: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Victor W Rosenfeld, Dana N Rutledge, John M Stern
PURPOSE: Characterize the polysomnographic (PSG) and quantitative EEG (qEEG) features of fibromyalgia and determine whether fibromyalgia patients differ in these measures when compared with a control sleep disorder population. METHODS: All undergoing all-night PSG for evaluation of a sleep disorder were evaluated for fibromyalgia. The PSGs were interpreted for routine sleep measures, and qEEG was performed to measure the delta and alpha frequency power during non-rapid eye movement sleep...
April 2015: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Mary Grace Umlauf, Anneliese C Bolland, Kathleen A Bolland, Sara Tomek, John M Bolland
Although sleep problems are associated with negative outcomes among adolescents, studies have not focused on sleep disorder symptoms among adolescents living in impoverished neighborhoods and how sleep problems may be related to two factors common in those environments: hopelessness and exposure to violence. This study used data from the longitudinal Mobile Youth Survey (MYS; N = 11,838, 49% female, 93% African-American) to examine trajectories of sleep problems by age (10-18 years) among impoverished adolescents as a function of gender, feelings of hopelessness, and exposure to violence...
February 2015: Journal of Youth and Adolescence
Sabine Scholle, Hans Christoph Scholle
OBJECTIVE: Age specific reference values of leg movements (LMS) and periodic leg movements (PLMS) in sleep considering their true periodicity to evaluate sleep pathologies, especially possible childhood RLS or PLMD. METHODS: In a prospective first night study of 52 healthy children/adolescents divided into six age groups from 1 to 18 years, polysomnographies were conducted and scored considering AASM rules. The frequency of LMS and PLMS were evaluated for NREM, REM, total sleep time (TST), including attention to time structure (inter-leg movement intervals, time distribution during the night) and periodicity of LMS...
September 2014: Sleep Medicine
Ozlem Abakay, Abdurrahman Abakay, Yilmaz Palanci, Hatice Yuksel, Hadice Selimoglu Sen, Osman Evliyaoglu, Abdullah Cetin Tanrikulu
PURPOSE: This study was aimed to assess potential correlations between periodic leg movement (PLM) index, hepcidin levels, and iron status in patients with obstructive sleep apnea syndrome (OSAS). METHODS: Forty-four newly diagnosed OSAS patients and 49 non-apneic controls were enrolled in this study. All patients underwent polysomnographic evaluation. The hepcidin, iron, ferritin, total iron binding capacity, and C-reactive protein levels were measured. RESULTS: The mean age was 47...
May 2015: Sleep & Breathing, Schlaf & Atmung
Nicole E Neerings-Verberkmoes, Monique H M Vlak, Lonneke M L de Lau, Hans L Hamburger
OBJECTIVE: To determine the sensitivity, specificity and the positive and negative predictive value of taking a detailed sleep history for making the diagnosis of psychophysiological insomnia. DESIGN: Retrospective case file study. METHOD: We examined 767 patients referred to the Amsterdam Centre for Sleep and Wake Disorders, and who underwent polysomnography for the first time between 1 January and 31 December 2010. We compared the probable diagnosis made following history-taking with the final diagnosis made after polysomnography...
2014: Nederlands Tijdschrift Voor Geneeskunde
K R Bharath Kumar Reddy, Michael Teik Chung Lim, Theodric Jun Lee, Daniel Yam Thiam Goh, Mahesh Babu Ramamurthy
OBJECTIVES: To investigate the indications for conducting polysomnography studies and their outcomes. METHODS: Retrospective analysis of pediatric polysomnography studies performed over a four-year period (2009-2012). RESULTS: 425 diagnostic studies and 100 non-invasive positive-pressure ventilation titration studies were conducted. Of these, 389 were performed in male children. Obstructive sleep apnea was the most common diagnosis; 49.6% (211 studies)...
June 2014: Indian Pediatrics
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