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Restless legs syndrome

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https://www.readbyqxmd.com/read/29458749/efficacy-of-ferric-carboxymaltose-fcm-500-mg-dose-for-the-treatment-of-restless-legs-syndrome
#1
Yong Won Cho, Richard P Allen, Christopher J Earley
INTRODUCTION: There have been four randomized, placebo-controlled, double-blinded studies of intravenous (IV) iron in Restless Legs Syndrome (RLS), all of which delivered a final total dose of 1000 mg of iron. The purpose of this study was to evaluate effects of a lesser total dose (500 mg of iron). METHODS: Subjects with idiopathic RLS were enrolled in a randomized, double-blinded, placebo-controlled study. Subjects received either 500 mg ferric carboxymaltose (FCM) or placebo as a single infusion (Phase I)...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29458705/reliability-of-the-structured-clinical-interview-for-dsm-5-sleep-disorders-module
#2
Daniel J Taylor, Allison K Wilkerson, Kristi E Pruiksma, Jacob M Williams, Camilo J Ruggero, Willie Hale, Jim Mintz, Katherine Marczyk Organek, Karin L Nicholson, Brett T Litz, Stacey Young-McCaughan, Katherine A Dondanville, Elisa V Borah, Antoinette Brundige, Alan L Peterson
STUDY OBJECTIVES: To develop and demonstrate interrater reliability for a Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Sleep Disorders (SCISD). METHODS: The SCISD was designed to be a brief, reliable, and valid interview assessment of adult sleep disorders as defined by the DSM-5. A sample of 106 postdeployment active-duty military members seeking cognitive behavioral therapy for insomnia in a randomized clinical trial were assessed with the SCISD prior to treatment to determine eligibility...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29458704/evaluation-of-cardiovascular-risk-factors-and-restless-legs-syndrome-in-women-and-men-a-preliminary-population-based-study-in-china
#3
Yuqiong Liu, Gangqiong Liu, Ling Li, Jing Yang, Shengli Ma
STUDY OBJECTIVES: Many studies have investigated the association between restless legs syndrome (RLS) and cardiovascular risk factors, leading to conflicting results. Therefore, the aim of the current study was to determine whether RLS is associated with cardiovascular risk factors and disease. METHODS: This cross-sectional study included 5,324 consecutive subjects who visited the Physical Examination Center of The First Affiliated Hospital of Zhengzhou University for their yearly routine physical examination...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29454715/-sleepiness-continuous-positive-airway-pressure-and-the-obstructive-sleep-apnea-hypopnea-syndrome
#4
REVIEW
L Lerousseau
Excessive daytime sleepiness is a major symptom in cases of the obstructive sleep apnea-hypopnea syndrome. Most often, it is vastly improved by treatment with continuous positive airway pressure (CPAP). The most effective way to confirm its disappearance is through wakefulness maintenance testing. If residual sleepiness remains, despite CPAP, further diagnostic investigation must be carried out. Firstly, it must be assessed whether the treatment is fully effective (apnea hypopnea index<10/h) by examining flow limitations under treatment (polysomnography) and whether it is sufficiently used (>6h/night)...
February 14, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29441041/altered-brain-functional-connectome-in-migraine-with-and-without-restless-legs-syndrome-a-resting-state-functional-mri-study
#5
Fu-Chi Yang, Kun-Hsien Chou, Ai-Ling Hsu, Jong-Ling Fuh, Jiing-Feng Lirng, Hung-Wen Kao, Ching-Po Lin, Shuu-Jiun Wang
Background: Migraine is frequently comorbid with restless legs syndrome (RLS), both displaying functional connectivity (FC) alterations in multiple brain networks, although the neurological basis of this association is unknown. Methods: We performed resting-state functional magnetic resonance imaging and network-wise analysis of FC in migraine patients with and without RLS and healthy controls (CRL). Network-based statistics (NBS) and composite FC matrix analyses were performed to identify the patterns of FC changes...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29440925/chronic-back-pain-cured-by-low-dose-levodopa-is-it-a-variant-of-restless-legs-syndrome
#6
Zhi-Fen Zeng, Yan-Ran Liang, Ying Chen, Xiu-Na Jing, Su-Dan Peng, En-Xiang Tao
Chronic back pain is one of the most common reasons for missed work and visits to the doctor. This report presents 2 interesting cases of chronic back pain that were effectively relieved by low-dose levodopa. These 2 patients showed no sign of anatomical problem of the spine or relative structures, but the discomforts on the back manifested some characteristics resembling those in restless legs syndrome (RLS), and one of them actually developed RLS after many years of back problem. We believe that this type of chronic back pain might be a variant of RLS, which we would like to call "restless back", and it can be effectively treated by dopaminergic drugs...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29434568/restless-legs-syndrome-willis-ekbom-disease-is-prevalent-in-working-nurses-but-seems-not-to-be-associated-with-shift-work-schedules
#7
Siri Waage, Ståle Pallesen, Bente Elisabeth Moen, Bjørn Bjorvatn
Insomnia and excessive sleepiness are among the most commonly reported sleep problems related to shift work. Sleep-related movement disorders have, however, received far less attention in relation to such work schedules. The objective of this study was to investigate the association between different shift work schedules and the prevalence of Restless legs syndrome/Willis-Ekbom disease (RLS/WED) in a large sample of Norwegian nurses. Our hypothesis was that shift working nurses would report higher prevalence of RLS/WED compared to day workers...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29432244/pediatric-sleep-disorders
#8
Kiran Maski, Judith Owens
PURPOSE OF REVIEW: This article provides an overview of the clinical features, diagnosis, and treatment of insomnia, restless legs syndrome, periodic limb movements of sleep, parasomnias, narcolepsy, and sleep-related breathing disorders among children and adolescents. RECENT FINDINGS: Pediatric presentations of sleep disorders differ from adult presentations, making diagnosis challenging. Specific clinical syndromes, such as cataplexy in children with narcolepsy type 1, can have an altogether different presentation compared to adult-onset symptoms, contributing to diagnostic delays and potential misdiagnoses...
February 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29430200/exploring-sleep-disorders-in-patients-with-chronic-kidney-disease
#9
REVIEW
Gaurav Nigam, Macario Camacho, Edward T Chang, Muhammad Riaz
Kidney disorders have been associated with a variety of sleep-related disorders. Therefore, researchers are placing greater emphasis on finding the role of chronic kidney disease (CKD) in the development of obstructive sleep apnea and restless legs syndrome. Unfortunately, the presence of other sleep-related disorders with CKDs and non-CKDs has not been investigated with the same clinical rigor. Recent studies have revealed that myriad of sleep disorders are associated with CKDs. Furthermore, there are a few non-CKD-related disorders that are associated with sleep disorders...
2018: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29427229/diabetic-painful-neuropathy-and-restless-legs-syndrome-in-diabetes
#10
EDITORIAL
Sanjay Kalra, Anu Gupta
Restless legs syndrome (RLS) and diabetic painful neuropathy (DPN) are two distinct neurological conditions, which share many similarities. As RLS occurs frequently in persons with diabetes, the differential diagnosis and management of RLS and DPN may pose a clinical challenge. This communication describes the etiopathogenesis, clinical features, investigations, and treatment of both conditions. It highlights the similarities and differences between RLS and DPN, and helps the physician plan a rational clinical and therapeutic approach...
February 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29425580/japanese-sleep-questionnaire-for-elementary-schoolers-jsq-es-validation-and-population-based-score-distribution
#11
Ayano Kuwada, Ikuko Mohri, Ryosuke Asano, Shigeyuki Matsuzawa, Kumi Kato-Nishimura, Ikuko Hirata, Takashi Mitsuhosi, Kuriko Kagitani-Shimono, Mariko Nakanishi, Masaya Tachibana, Yuko Ohno, Masako Taniike
OBJECTIVE: The Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES) was developed to measure the sleep habits and disturbances of Japanese children. The current study aimed to present psychometric properties and describe the score distribution of the JSQ-ES. In addition, it examined correlations between the sleep and daytime behavior of school-aged children. METHOD: Guardians of 4369 elementary school children and 100 children diagnosed with sleep disorders in two clinics completed the JSQ-ES...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29425576/evidence-based-and-consensus-clinical-practice-guidelines-for-the-iron-treatment-of-restless-legs-syndrome-willis-ekbom-disease-in-adults-and-children-an-irlssg-task-force-report
#12
Richard P Allen, Daniel L Picchietti, Michael Auerbach, Yong Won Cho, James R Connor, Christopher J Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W Winkelman
BACKGROUND: Brain iron deficiency has been implicated in the pathophysiology of RLS, and current RLS treatment guidelines recommend iron treatment when peripheral iron levels are low. In order to assess the evidence on the oral and intravenous (IV) iron treatment of RLS and periodic limb movement disorder (PLMD) in adults and children, the International Restless Legs Syndrome Study Group (IRLSSG) formed a task force to review these studies and provide evidence-based and consensus guidelines for the iron treatment of RLS in adults, and RLS and PLMD in children...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29425573/diurnal-variation-of-default-mode-network-in-patients-with-restless-legs-syndrome
#13
Jeonghun Ku, Yeong Seon Lee, Hyuk Won Chang, Christopher J Earley, Richard P Allen, Yong Won Cho
OBJECTIVE: Restless legs syndrome (RLS) patients compared to controls have been found to have abnormal patterns in the default mode network (DMN) in the morning when symptom threshold is the highest and symptoms are least likely to occur. If these morning abnormalities in DMN are pertinent to disease expression, then similar or further detectable differences may be expected on a nighttime assessment when RLS symptom threshold is at its lowest. The purpose of this study was to elucidate the potential neural mechanisms underlying the circadian aspect of RLS symptom expression by assessing diurnal changes in DMN...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29423337/istradefylline-for-restless-legs-syndrome-associated-with-parkinson-s-disease
#14
Maierdanjiang Nuermaimaiti, Genko Oyama, Chayut Kasemsuk, Nobutaka Hattori
No abstract text is available yet for this article.
2018: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29422930/haplotype-association-of-the-map2k5-gene-with-antipsychotics-induced-symptoms-of-restless-legs-syndrome-among-patients-with-schizophrenia
#15
Seung-Gul Kang, Yu Jin Lee, Young-Min Park, Leen Kim, Heon-Jeong Lee
Objective: Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of MAP2K5 are associated with antipsychotics-induced RLS in schizophrenia. Methods: We assessed antipsychotics-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group...
January 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29419528/sleep-disorders-as-primary-and-secondary-factors-in-relation-with-daily-functioning-in-medical-students
#16
Deldar Morad Abdulah, Rasoul Sabri Piro
BACKGROUND: College students experience various types of sleep disorders that impact daily functioning. Previous studies have focused on the effect of one sleep disorder. OBJECTIVE: Examine factors that might relate to several sleep disorders and the impacts of sleep disorders on the daily functioning in medical students. DESIGN: Cross-sectional study. SETTING: Medical college. SUBJECTS AND METHODS: A random sample of medical students from a public university was invited to participate in a cross-sectional study using the structured SLEEP-50 self-reported questionnaire...
January 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29419360/the-prevalence-of-restless-legs-syndrome-and-its-relationship-with-demographic-characteristics-and-medical-disorders-in-postmenopausal-iranian-women
#17
Roghieh Bagheri, Parvin Abedi, Parvaneh Mousavi, Nasrin Azimi
This study was conducted to evaluate the prevalence of restless legs syndrome (RLS) and its relationship with demographic factors and medical disorders on 980 postmenopausal women. Data was gathered using a demographic questionnaire and the International Restless Legs Syndrome Scale. The prevalence of RLS was 16.02% (157/980). Women with poor economic status were 3.37 and 2.33 times more likely to have RLS than women with a good economic situation and moderate economic status (CI:2.041-5.579, P≤0.0001) and (CI: 1...
February 8, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29418021/association-between-serum-hepcidin-level-and-restless-legs-syndrome
#18
Yves Dauvilliers, Sofiene Chenini, Jérôme Vialaret, Constance Delaby, Lily Guiraud, Audrey Gabelle, Regis Lopez, Christophe Hirtz, Isabelle Jaussent, Sylvain Lehmann
BACKGROUND: To better understand the role of iron homeostasis dysregulation in restless legs syndrome, we compared serum hepcidin and ferritin levels in drug-free patients with primary restless legs syndrome and healthy controls and studied the relationship between hepcidin level and restless legs syndrome severity. METHODS: One hundred and eight drug-free patients with primary restless legs syndrome (65 women; median age, 61.5 years) and 45 controls (28 women; median age, 53...
February 8, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29412984/neurodegenerative-disorders-and-sleep
#19
REVIEW
Raman K Malhotra
Sleep disorders are commonly found in cerebral degenerative disorders. The sleep disorders may be caused by the primary symptoms of the neurologic disease or may result from damage to sleep-controlling centers in the brain. Common sleep disorders found in this population include insomnia, hypersomnia, sleep apnea, restless legs syndrome, circadian rhythm disorders, and rapid eye movement sleep behavior disorder. The latter disorder can present years before other neurologic symptoms or signs are present, serving as a precursor of neurodegenerative conditions...
March 2018: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29412983/parasomnias-and-sleep-related-movement-disorders-in-older-adults
#20
REVIEW
Alex Iranzo
Parasomnias and sleep-related movement disorders are important problems in older adults. Sleep paralysis is rare, but may occur in families. In a minority of patients with disorders of arousal, the episodes persist until the age of 70. Zolpidem and other medications may induce sleepwalking and sleep-related eating. Most patients with idiopathic rapid eye movement (REM) sleep behavior disorder eventually develop Parkinson's disease or dementia with Lewy bodies. Anti-IgLON5 disease includes abnormal behaviors in NREM and REM sleep...
March 2018: Sleep Medicine Clinics
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