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https://www.readbyqxmd.com/read/29675716/disturbances-of-sleep-and-alertness-in-parkinson-s-disease
#1
REVIEW
Aleksandar Videnovic
PURPOSE OF REVIEW: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Sleep dysfunction is one of the most common non-motor manifestations of PD that has gained significant interest over the past two decades due to its impact on the daily lives of PD patients, poorly understood mechanisms, and limited treatment options. In this review, we discuss the most common sleep disorders in PD and present recent investigations that have broadened our understanding of the epidemiology, clinical manifestations, diagnosis, and treatment of disturbed sleep and alertness in PD...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29674254/the-association-between-obesity-and-restless-legs-syndrome-a-systemic-review-and-meta-analysis-of-observational-studies
#2
REVIEW
Song Lin, Huaqi Zhang, Tianlin Gao, Feng Zhong, Yongye Sun, Jing Cai, Aiguo Ma
OBJECTIVE: Restless legs syndrome (RLS) has been reported to occur more frequently in obese individuals than in those with normal weight. In this study, a systematic review and meta-analysis was performed to explore the relationship between obesity and RLS. METHODS: Published articles were identified through a comprehensive review of PUBMED and EMBASE from inception to the 16th December 2017. Data from studies reporting relative risks, odds ratios, or hazard ratios comparing the risk of RLS among individuals with obesity versus people with normal weight were analyzed...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29664425/assessment-of-cardiac-autonomic-functions-by-heart-rate-variability-in-patients-with-restless-leg-syndrome
#3
Abdülmelik Yıldız, Cennet Yıldız, Ahmet Karakurt
OBJECTIVE: The aim of the present study was to investigate cardiac autonomic effects in restless leg syndrome (RLS) using heart rate variability (HRV). METHODS: A total of 35 patients with RLS and 35 healthy individuals were enrolled in the study. The severity of RLS symptoms was assessed using the International Restless Legs Syndrome Study Group rating scale (IRLS). The correlation between the severity of RLS symptoms and HRV parameters measured on an electrocardiogram was analyzed...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29663852/decreased-sleep-quality-in-parkinson-s-patients-is-associated-with-higher-anxiety-and-depression-prevalence-and-severity-and-correlates-with-pain-intensity-and-quality
#4
Abdul Qayyum Rana, Abdul Rehman M Qureshi, Yazan Shamli Oghli, Yosuf Saqib, Bilal Mohammed, Zainab Sarfraz, Ruqqiyah Rana
OBJECTIVE: Pain, poor sleep quality, restless legs syndrome (RLS), and other symptoms are frequently reported by patients with Parkinson's disease (PD). However, the impact that pain severity and interference has on non-motor symptoms (NMS) has not been extensively studied. The objective of the present study is to explore the relationship between sleep quality in PD to pain and other NMS that affect quality of life. METHODS: The study included 100 PD patients and 100 age and gender-matched controls assessed for pain severity and pain interference using the Brief Pain Inventory and sleep quality using the Pittsburgh Sleep Quality Index...
April 17, 2018: Neurological Research
https://www.readbyqxmd.com/read/29623817/restless-legs-syndrome-in-patients-infected-with-helicobacter-pylori
#5
Farzaneh Rezvani, Mohammad Sayadnasiri, Omid Rezaei
Objective Although the etiology of restless legs syndrome (RLS) is yet to be discovered, some studies have mentioned the effect of infectious diseases in occurrence of RLS. This study aims to determine the association between common Helicobacter pylori (H. pylori) infection and occurrence of RLS. Methods In this descriptive analytical cross-sectional study, patients with RLS who were referred to the Internal Medicine Clinic of Fayazbakhsh Hospital in Tehran from September to December 2016 were evaluated. Patients with underlying diseases that would lead to secondary RLS were excluded from the study...
April 6, 2018: Neurological Research
https://www.readbyqxmd.com/read/29615884/central-disorders-of-hypersomnolence-restless-legs-syndrome-and-surgery-with-general-anesthesia-patient-perceptions
#6
Vincent LaBarbera, Paul S García, Donald L Bliwise, Lynn M Trotti
Introduction: The importance of obstructive sleep apnea in patients undergoing surgery with general anesthesia is well-defined, but the surgical and anesthetic implications of other sleep disorders are less clear. We sought to evaluate response to surgery with general anesthesia in patients with central disorders of hypersomnolence or restless legs syndrome. Methods: We surveyed patients on their most recent surgical procedure with general anesthesia, querying about procedure, recovery, and any changes in sleep disorder symptomatology following the procedure...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29610943/restless-legs-syndrome-is-a-relevant-comorbidity-in-patients-with-inflammatory-bowel-disease
#7
Janek Becker, Felix Berger, Katharina A Schindlbeck, Denis Poddubnyy, Peter M Koch, Jan C Preiß, Britta Siegmund, Frank Marzinzik, Jochen Maul
BACKGROUND AND AIMS: In patients with inflammatory bowel disease (IBD), restless legs syndrome (RLS) may occur as an extraintestinal disease manifestation. Iron deficiency (ID) or folate deficiency/vitamin B12 deficiency (FD/VB12 D) has previously been described to cause RLS. Here, we determined the prevalence and severity of RLS in IBD patients and evaluated the effect of iron and/or folic acid/vitamin B12 supplementation. METHODS: Patients were screened for ID and RLS by a gastroenterologist...
April 3, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29609719/the-association-between-vitamin-d-level-and-restless-legs-syndrome-a-population-based-case-control-study
#8
Siraj Wali, Samah Alsafadi, Bahaa Abaalkhail, Iman Ramadan, Badr Abulhamail, Moaiyyad Kousa, Reem Alshamrani, Hanan Faruqui, Abdulaziz Faruqui, Mohamed Alama, Mohamed Hamed
STUDY OBJECTIVES: The pathophysiology of restless legs syndrome (RLS) may be related to abnormalities in central dopamine pathways. Vitamin D may play a role in the pathophysiology of RLS by modulating the dopaminergic system. The aim of our study is to examine the possible link between RLS and vitamin D deficiency. METHODS: The total number of subjects enrolled was 201, including 78 patients with RLS based on the International RLS Study Group (IRLSSG) diagnostic criteria and 123 controls...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29606605/investigation-of-non-motor-symptoms-in-first-degree-relatives-of-patients-with-parkinson-s-disease
#9
Jiang-Bing Liu, Jun-Ling Leng, Xin-Jiang Zhang, Zhao-Xia Wang, Zuo-Wei Duan, Cheng-Jie Mao, Chun-Feng Liu
OBJECTIVE: Non-motor symptoms (NMS) are important prodromal characteristics of Parkinson's disease (PD). However, the incidence of NMS in first-degree relatives, such as siblings of PD patients, is still unknown. METHODS: A total of 98 PD patients of the Affiliated Hospital of Yangzhou University were recruited; 210 siblings of these patients were included in a first-degree relatives (FDR) group and 250 healthy individuals were included in a control group. Various scales were used to assess NMS, including depression, anxiety, cognitive function, sleep status, constipation, daytime sleepiness, Rapid-Eye-Movement Sleep Behavior Disorder (RBD), and Restless Legs Syndrome (RLS)...
March 27, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29602660/management-of-treatment-failure-in-restless-legs-syndrome-willis-ekbom-disease
#10
REVIEW
Diego Garcia-Borreguero, Irene Cano-Pumarega, Rafael Marulanda
Dopaminergic drugs have been widely used over the last decades for the treatment of restless legs syndrome (RLS)/Willis-Ekbom disease (WED). While the majority of studies show an initial improvement in symptoms, longer studies and clinical experience show that either treatment efficacy decreases with time, and/or augmentation develops: dopaminergic augmentation has been reported to be the main reason for treatment discontinuation and treatment failure in RLS/WED. The current review discusses the main reasons for treatment failure in RLS/WED and outlines the most recent expert-based strategies to prevent and manage it...
January 9, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29599901/management-of-restless-legs-syndrome-in-chronic-liver-disease-a-challenge-for-the-correct-diagnosis-and-therapy
#11
Rita Moretti, Paola Caruso, Marzia Tecchiolli, Silvia Gazzin, Claudio Tiribelli
AIM: To investigate the association between restless legs syndrome (RLS) and well-defined chronic liver disease, and the possible therapeutic options. METHODS: Two hundred and eleven patients with chronic liver disease, complaining of sleep disturbances, painful leg sensation and daily sleepiness, were included. Patients with persistent alcohol intake, recent worsening of clinical conditions, or hepatitis C virus were excluded. Diagnosis of RLS was suggested by the Johns Hopkins questionnaire and verified by fulfilling the diagnostic criteria by Allen...
March 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29599746/peripheral-dopamine-in-restless-legs-syndrome
#12
Ulrike H Mitchell, J Daniel Obray, Erik Hunsaker, Brandon T Garcia, Travis J Clarke, Sandra Hope, Scott C Steffensen
Objective/Background: Restless Legs Syndrome (RLS) is a dopamine-dependent disorder characterized by a strong urge to move. The objective of this study was to evalulate blood levels of dopamine and other catecholamines and blood D2-subtype dopamine receptors (D2Rs) in RLS. Patients/Methods: Dopamine levels in blood samples from age-matched unmedicated RLS subjects, medicated RLS subjects and Controls were evaluated with high performance liquid chromatography and dopamine D2R white blood cell (WBC) expression levels were determined with fluorescence-activated cell sorting and immunocytochemistry...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29587340/genetic-variations-associated-with-sleep-disorders-in-patients-with-schizophrenia-a-systematic-review
#13
REVIEW
Konstantinos Assimakopoulos, Katerina Karaivazoglou, Maria Skokou, Marina Kalogeropoulou, Panagiotis Kolios, Philippos Gourzis, George P Patrinos, Evangelia Eirini Tsermpini
Background: Schizophrenic patients commonly suffer from sleep disorders which are associated with acute disease severity, worsening prognoses and a poorer quality of life. Research is attempting to disentangle the complex interplay between schizophrenia and sleep disturbances by focusing not only on demographic and clinical characteristics, but also on the identification of genetic factors. Methods: Here, we performed a systematic literature review on the topic of genetic variations in sleep-disordered schizophrenic patients in an attempt to identify high quality investigations reporting scientifically sound and clinically useful data...
March 24, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29577828/restless-legs-syndrome-in-multiple-sclerosis-patients-a-contributing-factor-for-fatigue-impaired-functional-capacity-and-diminished-health-related-quality-of-life
#14
Christoforos D Giannaki, Panagiotis Aristotelous, Manos Stefanakis, Georgios M Hadjigeorgiou, Mauro Manconi, Eleni Leonidou, Giorgos K Sakkas, Marios Pantzaris
Objectives Restless legs syndrome (RLS) symptoms are common in Multiple Sclerosis (MS) patients. The aim of the current study was to examine for the first time whether RLS could affect the functional capacity and various contributing parameters related to quality of life and fatigue in MS patients. Methods According to their RLS status, 50 relapsing-remitting MS patients were divided into the RLS (n = 10) and non-RLS groups (n = 40). Specific questionnaires were used in order to assess the health-related quality of life (HRQoL), fatigue levels, sleep quality, daily sleepiness, and depression symptoms of the patients...
March 26, 2018: Neurological Research
https://www.readbyqxmd.com/read/29561180/non-pharmacological-interventions-for-restless-legs-syndrome-a-systematic-review-of-randomised-controlled-trials
#15
Eloise G Harrison, Jennifer L Keating, Prue E Morgan
INTRODUCTION: Restless legs syndrome (RLS) is a sensorimotor disorder characterised by an uncomfortable urge to move the legs. Management is primarily pharmacological. Effects for non-pharmacological, non-surgical options are published but lack systematic examination. OBJECTIVES: To synthesise results of non-pharmacological/non-surgical treatment compared to no-treatment controls or alternative treatment for RLS on any relevant outcome. METHODS: Databases and reference lists of reviews were searched for randomised controlled trials (RCTs) comparing non-pharmacological treatment to alternative or no treatment controls for idiopathic RLS...
March 21, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29560376/reflection-impulsivity-perceptual-decision-making-in-patients-with-restless-legs-syndrome
#16
Beatrice Heim, Marie-Theres Pertl, Ambra Stefani, Anna Heidbreder, Laura Zamarian, Elisabeth Brandauer, Bruno Averbeck, Margarete Delazer, Klaus Seppi, Birgit Högl, Werner Poewe, Atbin Djamshidian
Objectives: The objective of this study was to investigate perceptual decision-making and reflection impulsivity in drug naïve patients with restless legs syndrome (RLS) and patients with dopaminergic therapy. Methods: A total of 35 RLS patients (20 who were drug naïve regarding dopaminergic medication and 15 patients treated with dopaminergic therapy without augmentation or impulse control disorders) were included in this study. We used the Beads task and the Pixel task which assess reflection impulsivity and perceptual decision-making, respectively...
March 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29554362/screening-for-idiopathic-rem-sleep-behavior-disorder-usefulness-of-actigraphy
#17
A Stefani, A Heidbreder, E Brandauer, M Guaita, L M Neier, T Mitterling, J Santamaria, A Iranzo, A Videnovic, C Trenkwalder, F Sixel-Döring, G K Wenning, A Chade, W Poewe, O S Gershanik, B Högl
Study objective: To evaluate the utility of multimodal low-cost approaches including actigraphy, a wrist-worn device monitoring rest/activity cycles, in identifying patients with idiopathic REM sleep behavior disorder (iRBD). Methods: Seventy patients diagnosed with sleep disorders causing different motor manifestations during sleep (iRBD, sleep apnea, restless legs syndrome) and 20 subjects without any relevant motor manifestation during sleep, underwent video-polysomnography (vPSG) and two-week actigraphy, completed six validated RBD screening questionnaires, and sleep apps use was assessed...
March 15, 2018: Sleep
https://www.readbyqxmd.com/read/29550236/clinically-oriented-subtyping-of-chronic-insomnia-of-childhood
#18
Oliviero Bruni, Stefania Sette, Marco Angriman, Emma Baumgartner, Lara Selvaggini, Cristina Belli, Raffaele Ferri
OBJECTIVES: To identify different profiles of pediatric insomnia, based on the most frequent clinical presentations (nocturnal awakenings, difficulty in falling asleep, nocturnal restlessness, early morning awakenings). STUDY DESIGN: A structured parent interview was conducted in 338 children (mean age 21.29 months, SD 10.56) referred by pediatricians because of insomnia resistant to behavioral approaches and common drug treatments. The aim was to assess the characteristics of insomnia in children, together with family sleep-related history...
March 15, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29539610/migraine-and-headache-prevalence-and-associated-comorbidities-in-a-large-saudi-sample
#19
Taim Muayqil, Bandar N Al-Jafen, Zaid Al-Saaran, Mohammed Al-Shammari, Abdulrahman Alkthiry, Wejdan S Muhammad, Rozan Murshid, Mohammed H Alanazy
BACKGROUND: We aimed to assess the prevalence of headache and migraine, along with comorbidities, in a large -Saudi sample. METHODS: Self-reported information was collected about headache, migraine and migraine comorbidities including depression, restless legs syndrome (RLS), syncope, bruxism, hypertension and ischaemic disease. The OR was estimated using logistic regression for any associations with headache and migraine. We then analyzed to find a trend of increasing migraine symptoms for each significant comorbidity...
March 14, 2018: European Neurology
https://www.readbyqxmd.com/read/29530369/adherence-and-persistence-to-ropinirole-pramipexole-and-gabapentin-in-patients-with-newly-diagnosed-restless-legs-syndrome
#20
Juhyeun Kim, Abraham G Hartzema
STUDY OBJECTIVES: The objective of this study is to assess adherence and persistence of ropinirole, pramipexole, and gabapentin; to investigate factors associated with non-adherence and non-persistence in restless legs syndrome (RLS) patients. METHODS: We used the 2008-2014 Marketscan® Research Databases to conduct a retrospective data analysis. The study included newly diagnosed RLS patients who initiated ropinirole, pramipexole, or gabapentin therapy. During 365 days of follow-up, mean medication possession ratios (MPRs) for adherence and the proportion of adherent users were calculated...
April 2018: Sleep Medicine
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