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https://www.readbyqxmd.com/read/28636929/intrinsic-functional-connectivity-alteration-of-dorsal-and-rostral-anterior-cingulate-cortex-in-obsessive-compulsive-disorder-a-resting-fmri-study
#1
Zongfeng Zhang, Qing Fan, Yajing Zhu, Ling Tan, Yongjun Chen, Rui Gao, Haiyin Zhang, Yao Li, Zeping Xiao
Cortico-striato-thalamo-cortical (CSTC) circuit has been implicated in OCD pathophysiology by converging neuroimaging findings. The anterior cingulate cortex (ACC), as an important part within CSTC circuit, plays a critical role in OCD etiology. The ACC can be divided into dorsal and rostral parts anatomically, which are involved in cognitive process and emotional function, respectively. However, the diverse function of intrinsic signals from dorsal and rostral ACC regions remains unclear in OCD study. In this work, we applied resting-state functional magnetic resonance imaging (rs-fMRI) technology to investigate and differentiate the functional connectivity (FC) characteristics between dACC and rACC in unmedicated OCD patients...
June 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28636705/inflammation-in-the-neurocircuitry-of-obsessive-compulsive-disorder
#2
Sophia Attwells, Elaine Setiawan, Alan A Wilson, Pablo M Rusjan, Romina Mizrahi, Laura Miler, Cynthia Xu, Margaret Anne Richter, Alan Kahn, Stephen J Kish, Sylvain Houle, Lakshmi Ravindran, Jeffrey H Meyer
Importance: For a small percentage of obsessive-compulsive disorder (OCD) cases exhibiting additional neuropsychiatric symptoms, it was proposed that neuroinflammation occurs in the basal ganglia as an autoimmune response to infections. However, it is possible that elevated neuroinflammation, inducible by a diverse range of mechanisms, is important throughout the cortico-striato-thalamo-cortical circuit of OCD. Identifying brain inflammation is possible with the recent advance in positron emission tomography (PET) radioligands that bind to the translocator protein (TSPO)...
June 21, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28636668/microbiota-in-anorexia-nervosa-the-triangle-between-bacterial-species-metabolites-and-psychological-tests
#3
Francesca Borgo, Alessandra Riva, Alberto Benetti, Maria Cristina Casiraghi, Sara Bertelli, Stefania Garbossa, Simona Anselmetti, Silvio Scarone, Antonio E Pontiroli, Giulia Morace, Elisa Borghi
Anorexia nervosa (AN) is a psychiatric disease with devastating physical consequences, with a pathophysiological mechanism still to be elucidated. Metagenomic studies on anorexia nervosa have revealed profound gut microbiome perturbations as a possible environmental factor involved in the disease. In this study we performed a comprehensive analysis integrating data on gut microbiota with clinical, anthropometric and psychological traits to gain new insight in the pathophysiology of AN. Fifteen AN women were compared with fifteen age-, sex- and ethnicity-matched healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28636577/comorbidity-and-suicidality-in-patients-diagnosed-with-panic-disorder-agoraphobia-and-major-depression
#4
Borjanka Batinic, Goran Opacic, Tijana Ignjatov, David S Baldwin
BACKGROUND: Comorbidity of anxiety and depression (both current and lifetime) is associated with greater chronicity and an increased risk of suicidality. We wished to ascertain which symptom clusters had the strongest association with suicidality. Our aims were (1) to examine the presence of current comorbidity and suicidality in patients diagnosed with panic disorder/agoraphobia (PD/A) and major depression (MD), and their relationship with duration of psychiatric treatment and frequency of hospital admission; and (2) to examine which coexisting symptoms were most strongly predictive of suicidality in sub-groups and the overall group...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28634107/chronic-pramipexole-treatment-induces-compulsive-behavior-in-rats-with-6-ohda-lesions-of-the-substantia-nigra-and-ventral-tegmental-area
#5
D Dardou, L Reyrolle, C Chassain, F Durif
Dopamine replacement therapy (DRT) reduces motor symptoms in Parkinson's disease (PD), but also induces impulsive-compulsive behavior (ICB) in up to 25% of PD patients. These non-motor side effects of DRT generally follow a gradual transition from impulsive to compulsive-like-i.e. repetitive, compelled, and non-pleasurable-behavior. Here, we investigated the effect of chronic pramipexole (PPX) treatment on the onset of compulsive-like behavior, measured via the post-training signal attenuation (PTSA) procedure, in rats with dopaminergic lesions...
June 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28632120/basolateral-amygdala-ventromedial-prefrontal-cortex-connectivity-predicts-cognitive-behavioural-therapy-outcome-in-adults-with-obsessive-compulsive-disorder
#6
Miquel A Fullana, Xi Zhu, Pino Alonso, Narcís Cardoner, Eva Real, Clara López-Solà, Cinto Segalàs, Marta Subirà, Hanga Galfalvy, José M Menchón, H Blair Simpson, Rachel Marsh, Carles Soriano-Mas
BACKGROUND: Cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences in basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict CBT outcome in patients with OCD. METHODS: We investigated whether BLA-vmPFC resting-state functional connectivity (rs-fc) predicts CBT outcome in patients with OCD...
June 20, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28632074/isopropyl-alcohol-swabs-as-a-preferred-substance-of-abuse
#7
Aditi Sharma, Jonathan D Morrow
The authors describe the treatment of a 36-year-old woman who presented with excessive consumption of antiseptic alcohol swabs. Her behavior was diagnosed as a severe substance use disorder with isopropyl alcohol as the primary drug of choice. Diagnostic and treatment challenges involved in the case are discussed in detail, with particular focus on the differential diagnosis for this unusual presentation, including obsessive compulsive disorder, pica, and intentional self-injurious behavior. A brief review of the literature on non-ethanol ingestion for the purposes of intoxication is included, as well as clinical information about the potential dangers posed by isopropyl alcohol consumption...
February 26, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28632003/factor-structure-of-the-urdu-version-of-the-spence-children-s-anxiety-scale-in-pakistan
#8
Farah Qadir, Aneela Maqsood, Najam Us-Sahar, Nadia Bukhtawer, Amna Khalid, Regina Pauli, Catherine Gilvarry, Girmay Medhin, Cecilia A Essau
Spence Children's Anxiety Scale (SCAS) is one of the most commonly used self-report questionnaires to measure symptoms of anxiety disorders in adolescents. Despite its common use, studies that examine the psychometric properties of SCAS in Pakistan is lacking. Therefore, the purpose of this study was to examine the psychometric properties of the Urdu translated version of the SCAS among adolescents in Pakistan. A total of 1277 students (708 boys and 569 girls), aged 13 to17 years, who had been recruited from 13 schools in Rawalpindi, Pakistan participated in the study...
March 3, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28631520/striatal-changes-underlie-mpep-mediated-suppression-of-the-acquisition-and-expression-of-pramipexole-induced-place-preference-in-an-alpha-synuclein-rat-model-of-parkinson-s-disease
#9
Simon Loiodice, Portia McGhan, Vitalina Gryshkova, Renaud Fleurance, David Dardou, Aziz Hafidi, Andre Nogueira da Costa, Franck Durif
Impulsive-compulsive disorders in Parkinson's disease patients have been described as behavioural or substance addictions including pathological gambling or compulsive medication use of dopamine replacement therapy. A substantial gap remains in the understanding of these disorders. We previously demonstrated that the rewarding effect of the D2/D3 agonist pramipexole was enhanced after repeated exposure to L-dopa and alpha-synuclein mediated dopaminergic nigral loss with specific transcriptional signatures suggesting a key involvement of the glutamatergic pathway...
June 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28631412/psychopathology-in-pediatric-bone-marrow-transplantation-survivors-and-their-mothers
#10
Aslı Sürer Adanir, Gülseren Taşkiran, O Alphan Küpesiz, Esin Özatalay
BACKGROUND: Bone Marrow Transplantation(BMT) is used to treat children with various hematologic, oncologic and metabolic diseases. While the treatment is lifesaving, it is also found to be related with anxiety, posttraumatic stress disorder, depression and psychosocial problems both in children and parents. METHODS: The aim of this study was to investigate psychopathology in pediatric BMT survivors and their mothers compared to the healthy controls. All children were interviewed using Kiddie Schedule for Affective Disorders and Schizophrenia for assessing the life-long psychopathology...
June 20, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28628809/distrust-of-the-senses-and-its-association-with-obsessive-compulsive-symptoms
#11
Shiu F Wong, Alishia D Williams, Jessica R Grisham
BACKGROUND AND OBJECTIVES: Leading cognitive theories of OCD suggests that despite prevalent and persistent doubt, individuals with OCD do not have perceptual deficits. An alternate cognitive theory, the Seeking Proxies for Internal States hypothesis (SPIS), proposes that sensory distrust in OCD stems from actual deficits in accessing internal states. Consistent with the SPIS, previous research has found that high-OC individuals were less accurate than low-OC individuals in producing target levels of muscle tension in a biofeedback task and that OC symptoms were positively associated with reliance on an external proxy...
June 13, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28627133/mesocorticolimbic-hemodynamic-response-in-parkinson-s-disease-patients-with-compulsive-behaviors
#12
Daniel O Claassen, Adam J Stark, Charis A Spears, Kalen J Petersen, Nelleke C van Wouwe, Robert M Kessler, David H Zald, Manus J Donahue
BACKGROUND: PD patients treated with dopamine therapy can develop maladaptive impulsive and compulsive behaviors, manifesting as repetitive participation in reward-driven activities. This behavioral phenotype implicates aberrant mesocorticolimbic network function, a concept supported by past literature. However, no study has investigated the acute hemodynamic response to dopamine agonists in this subpopulation. OBJECTIVES: We tested the hypothesis that dopamine agonists differentially alter mesocortical and mesolimbic network activity in patients with impulsive-compulsive behaviors...
June 19, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28622206/bupropion-augmentation-in-a-case-of-compulsive-buying-disorder
#13
Gianna Sepede, Giuseppe Di Iorio, Fabiola Sarchione, Federica Fiori, Massimo Di Giannantonio
BACKGROUND: Compulsive buying disorder (CBD) is a condition characterized by excessive preoccupations, impulses, and behaviors regarding buying, resulting in serious psychological, social, and financial problems. Even though it has not been included in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, "behavioral addictions" section, CBD is a hot topic in current clinical psychiatry, because of its relevant prevalence (at least 5% in adult populations) and severe effect on quality of life...
June 16, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28617566/randomized-double-blind-placebo-controlled-trial-of-n-acetylcysteine-augmentation-for-treatment-resistant-obsessive-compulsive-disorder
#14
Daniel L C Costa, Juliana B Diniz, Guaraci Requena, Marinês A Joaquim, Christopher Pittenger, Michael H Bloch, Euripedes C Miguel, Roseli G Shavitt
OBJECTIVE: To evaluate the efficacy of serotonin reuptake inhibitor (SRI) augmentation with N-acetylcysteine (NAC), a glutamate modulator and antioxidant medication, for treatment-resistant obsessive-compulsive disorder (OCD). METHODS: We conducted a randomized, double-blind, placebo-controlled, 16-week trial of NAC (3,000 mg daily) in adults (aged 18-65 years) with treatment-resistant OCD, established according to DSM-IV criteria. Forty subjects were recruited at an OCD-specialized outpatient clinic at a tertiary hospital (May 2012-October 2014)...
June 6, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28617347/repetitive-behaviours-and-restricted-interests-in-individuals-with-down-syndrome-one-way-of-managing-their-world
#15
Sheila Glenn
This paper argues that the repetitive behaviour and restrictive interests (RBRI) displayed by individuals with Down syndrome have mostly positive functions. However, as research has developed from interests in Obsessional Compulsive Disorder or Autistic Spectrum Disorder, unfortunately a view has arisen that RBRI in individuals with Down syndrome are also likely to be pathological. This is particularly the case in adults. The paper reviews: (a) measures employed and the perspectives that have been used; (b) the development in typically developing individuals, those with Down syndrome, and those with other conditions associated with intellectual disability; (c) positive and possible negative effects of RBRI; and (d) the need for more research...
June 15, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28615788/shared-or-induced-obsessive-compulsive-disorder-a-case-report-with-critical-review
#16
Snehil Gupta, Sathya Prakash, Pratap Sharan
No abstract text is available yet for this article.
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28615782/comment-on-dance-like-movements-in-obsessive-compulsive-disorder
#17
Pooja Yudhishthir Palkar, Anand Ajit Kumthekar
No abstract text is available yet for this article.
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28615781/-radio-inside-my-head-a-curious-case-of-early-onset-stuck-song-syndrome-or-obsessive-compulsive-disorder-with-predominant-musical-obsession
#18
Subrata Naskar, Robin Victor, Kamal Nath, Hasina Anjuman Choudhury
Musical obsessions also called "stuck song syndrome" is a topic of limited research. It is among the most poorly understood and rare phenomenology. There are only a few cases reported across the world which describes it. Subjects usually present with complaints of continuous play of a musical tune in the head which the subject is unable to remove. Because of its similarity in presentation with auditory musical hallucination, it presents a diagnostic dilemma to the clinician. Here, we present the case of a 25-year-old man who presented with this particular phenomenon, and the approach we took to manage it...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28615780/converging-neurobiological-evidence-in-primary-polydipsia-resembling-obsessive-compulsive-disorder
#19
Karthick Subramanian, Tess Maria Rajan, Vikas Menon, Ravi Philip Rajkumar
Compulsive water drinking can have phenomenological and pharmacotherapeutic similarities with obsessive-compulsive disorder (OCD). Substantiating neurobiological evidence is lacking for such an association. We report a patient who was referred with a diagnosis of primary polydipsia with no signs of organic pathology in structural neuroimaging. However, positron emission tomography revealed basal ganglia hypometabolism indicating that primary polydipsia with compulsive water drinking is neurobiologically related to OCD...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28608743/obsessive-compulsive-disorder-which-genes-which-functions-which-pathways-an-integrated-holistic-view-regarding-ocd-and-its-complex-genetic-etiology
#20
Ali Bozorgmehr, Mohammad Ghadirivasfi, Esmaeil Shahsavand Ananloo
Obsessive-compulsive disorder (OCD) is characterized by recurrent obtrusive and repetitive acts typically occurred following anxiety. In the last two decades, studies done on the gene sequences, large-scale and point mutations and gene-gene, gene-environment and gene-drug interactions have led to the discovery of hundreds of genes associated with OCD. Although each gene in turn is a part of the etiology of this disorder; however, OCD, like other mental disorders is complex and a comprehensive and integrated view is necessary to understand its genetic basis...
June 13, 2017: Journal of Neurogenetics
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