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https://www.readbyqxmd.com/read/28432226/everolimus-plus-exemestane-in-advanced-breast-cancer-safety-results-of-the-ballet-study-on-patients-previously-treated-without-and-with-chemotherapy-in-the-metastatic-setting
#1
Daniele Generali, Filippo Montemurro, Roberto Bordonaro, Antonino Mafodda, Sante Romito, Andrea Michelotti, Pierluigi Piovano, Maria Teresa Ionta, Claudia Bighin, Donata Sartori, Antonio Frassoldati, Marina Elena Cazzaniga, Ferdinando Riccardi, Franco Testore, Patrizia Vici, Carlo Antonio Barone, Alessio Schirone, Federico Piacentini, Franco Nolè, Annamaria Molino, Luciano Latini, Edda Lucia Simoncini, Fausto Roila, Francesco Cognetti, Francesco Nuzzo, Jennifer Foglietta, Alessandro Marco Minisini, Francesca Goffredo, Giuseppe Portera, Gilda Ascione, Gabriella Mariani
BACKGROUND: The BALLET study was an open-label, multicenter, expanded access study designed to allow treatment with everolimus plus exemestane in postmenopausal women with hormone receptor-positive metastatic breast cancer progressed following prior endocrine therapy. A post hoc analysis to evaluate if previous chemotherapy in the metastatic setting affects the safety profile of the combination regimen of everolimus and exemestane was conducted on the Italian subset, as it represented the major part of the patients enrolled (54%)...
April 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28380256/investigation-of-the-mycobacterial-enzyme-hsad-as-a-potential-novel-target-for-anti-tubercular-agents-using-a-fragment-based-drug-design-approach
#2
Ali Ryan, Elena Polycarpou, Nathan A Lack, Dimitrios Evangelopoulos, Christian Sieg, Alice Halman, Sanjib Bhakta, Olga Eleftheriadou, Timothy D McHugh, Sebastian Keany, Edward D Lowe, Romain Ballet, Areej Abuhammad, William R Jacobs, Alessio Ciulli, Edith Sim
BACKGROUND AND PURPOSE: With the emergence of extensively drug-resistant tuberculosis there is a need for new anti-tubercular drugs that work through novel mechanisms of action. The meta cleavage product hydrolase, HsaD, has been demonstrated to be critical to the survival of Mycobacterium tuberculosis in macrophages and is encoded in an operon involved in cholesterol catabolism, which is identical in M. tuberculosis and M. bovis BCG. EXPERIMENTAL APPROACH: We generated a mutant strain of M...
April 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28377289/golgi-trafficking-defects-in-postnatal-microcephaly-the-evidence-for-golgipathies
#3
REVIEW
Sandrine Passemard, Franck Perez, Emilie Colin-Lemesre, Sowmyalakshmi Rasika, Pierre Gressens, Vincent El Ghouzzi
The Golgi apparatus plays a central role in cell homeostasis, not only in processing and maturing newly synthesized proteins and lipids but also in orchestrating their sorting, packing, routing and recycling on the way to their final destination. These multiple secretory pathways require a complex ballet of vesicular and tubular carriers that continuously bud off from donor membranes and fuse to acceptor membranes. Membrane trafficking is particularly prominent in axons, where cargo molecules have a long way to travel before they reach the synapse, and in oligodendrocytes, which require an immense increase in membrane surface in order to sheathe axons in myelin...
April 1, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28364614/life-history-and-point-prevalence-of-low-back-pain-in-pre-professional-and-professional-dancers
#4
Christopher T V Swain, Elizabeth J Bradshaw, Douglas G Whyte, Christina L Ekegren
OBJECTIVES: To investigate lifetime history and point prevalence of low back pain (LBP) in pre-professional and professional dancers and to identify any demographic or physical factors associated with LBP in dancers. DESIGN: Cross-sectional study. SETTING: One pre-professional ballet school, two pre-professional university dance programs, and a professional nationally touring ballet company. PARTICIPANTS: Male and female classical ballet and contemporary dancers aged 12 years old and above...
January 24, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28347772/bifunctional-opioid-nociceptin-hybrid-kgnop1-effectively-attenuates-pain-related-behaviour-in-a-rat-model-of-neuropathy
#5
Joanna Starnowska, Karel Guillemyn, Wioletta Makuch, Joanna Mika, Steven Ballet, Barbara Przewlocka
A bifunctional peptide containing an opioid and nociceptin receptor-binding pharmacophore, H-Dmt-D-Arg-Aba-β-Ala-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2 (KGNOP1), was tested for its analgesic properties when administered intrathecally in naïve and chronic constriction injury (CCI)-exposed rats with neuropathy-like symptoms. KGNOP1 significantly increased the acute pain threshold, as measured by the tail-flick test, and also increased the threshold of a painful reaction to mechanical and thermal stimuli in CCI-exposed rats...
March 24, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28338396/should-ballet-dancers-vary-postures-and-under-foot-surfaces-when-practicing-postural-balance
#6
Nili Steinberg, Gordon Waddington, Roger Adams, Janet Karin, Oren Tirosh
BACKGROUND: Postural balance (PB) is an important component skill for professional dancers. However, the effects of different types of postures and different underfoot surfaces on PB have not been adequately addressed. PURPOSE: The main aim of the present study was to investigate the effect of different conditions of footwear, surfaces, and standing positions on static and dynamic PB ability of young ballet dancers. METHOD: Thirty-six male and female young professional ballet dancers (aged 14-19) completed static and dynamic balance testing, measured by head and lumbar accelerometers, while standing on one leg in the turn-out position, under six different conditions: 1...
March 24, 2017: Motor Control
https://www.readbyqxmd.com/read/28319437/translation-regulator-ballet-in-meiotic-spindle
#7
Patrick Cormier
No abstract text is available yet for this article.
April 18, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28282478/the-relationship-between-muscular-strength-and-dance-injuries-a-systematic-review
#8
REVIEW
João P Moita, Alexandre Nunes, José Esteves, Raul Oliveira, Luis Xarez
BACKGROUND: The physical demands placed on dancers put them at significant risk for injury, with rates similar to ones sustained by athletes in sports at the same level of performance. Muscle strength has been suggested to play a preventative role against injury in dancers. OBJECTIVE: To systematically search and examine the available evidence on the protective role of muscle strength in dance injuries. METHODS: Five electronic databases and two dance-specific science publications were screened up to September 2015...
March 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/28264664/experience-dependent-modulation-of-alpha-and-beta-during-action-observation-and-motor-imagery
#9
Paula M Di Nota, Julie M Chartrand, Gabriella R Levkov, Rodrigo Montefusco-Siegmund, Joseph F X DeSouza
BACKGROUND: EEG studies investigating the neural networks that facilitate action observation (AO) and kinaesthetic motor imagery (KMI) have shown reduced, or desynchronized, power in the alpha (8-12 Hz) and beta (13-30 Hz) frequency bands relative to rest, reflecting efficient activation of task-relevant areas. Functional modulation of these networks through expertise in dance has been established using fMRI, with greater activation among experts during AO. While there is evidence for experience-dependent plasticity of alpha power during AO of dance, the influence of familiarity on beta power during AO, and alpha and beta activity during KMI, remain unclear...
March 6, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28242800/rupture-of-the-extensor-hood-of-the-fifth-toe-a-rare-injury
#10
Sara Venturini, Suchi Gaba, Jitendra Mangwani
Closed injuries of the extensor hood of the lesser toes are rare and seldom reported in the literature. We present the case of a woman aged 25 years who presented to the orthopaedic fracture clinic with a 2-week history of pain in the left fifth toe and inability to extend following a ballet dancing session. Investigations showed no fracture on plain radiographs, but an ultrasound scan demonstrated rupture to the extensor hood of the little toe. Successful surgical repair of the extensor hood was performed, and the patient made a good recovery with return to dancing activities...
February 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28222210/snapping-hip-syndrome-systematic-review-of-surgical-treatment
#11
Gabriele Potalivo, Walter Bugiantella
The snapping hip (SH) syndrome is characterised by an audible snapping, often accompanied by pain, which usually occurs with the flexion and extension of the hip during exercise or ordinary daily activities.The causes of SH can be classified as external, internal and intraarticular. The prevalence of asymptomatic SH in the population is unknown and the incidence of symptomatic cases is not well-defined. The painless snapping in the hip is common in the general population; the symptomatic SH with debilitating pain and weakness is often seen in those who take part in activities such as ballet and running hurdles...
March 31, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28220914/the-association-between-body-built-and-injury-occurrence-in-pre-professional-ballet-dancers-separated-analysis-for-the-injured-body-locations
#12
Petra Zaletel, Damir Sekulić, Nataša Zenić, Michael R Esco, Dorica Šajber, Miran Kondrič
OBJECTIVES: This study has aimed at identifying prevalence of injury-occurrence in 24 pre-professional-ballet-dancers (females, 16-18 years of age), and identifying the associations between the body-built and prevalence of injuries. MATERIAL AND METHODS: The sample of variables included: body mass, body height, and 3 somatotype characteristics (mesomorph, ectomorph and endomorph) and data on injuries over the preceding year. RESULTS: Dancers were mostly ectomorphic-mesomorph (endomorphy: 2...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28215758/living-autobiographically-concepts-of-aging-and-artistic-expression-in-painting-and-modern-dance
#13
Mita Banerjee, Anita Wohlmann, Ralf Dahm
This article discusses the ways in which artists have incorporated or failed to incorporate the aging process of their bodies into their art. Using Russian ballet dancer Mikhail Baryshnikov and the French painter Claude Monet as cases in point, we explore situations in which physical changes brought about by aging compromises artists' ability to engage with their artistic medium. Connecting Monet's oeuvre and Baryshnikov's dance performances to life writing accounts, we draw on John Paul Eakin's concept of "living autobiographically": In this vein, life writing research does not only have to take into account concepts of identity as they emerge from life writing narratives, but it also needs to explore the somatic, corporeal and material dimensions of these narratives...
January 2017: Journal of Aging Studies
https://www.readbyqxmd.com/read/28196030/physical-activities-and-lifestyle-factors-related-to-adolescent-idiopathic-scoliosis
#14
Kota Watanabe, Takehiro Michikawa, Ikuho Yonezawa, Masashi Takaso, Shohei Minami, Shigeru Soshi, Takashi Tsuji, Eijiro Okada, Katsumi Abe, Masamichi Takahashi, Keiko Asakura, Yuji Nishiwaki, Morio Matsumoto
BACKGROUND: In addition to genetic factors, environmental and lifestyle factors are thought to play an important role in the onset of adolescent idiopathic scoliosis (AIS). This cross-sectional study was conducted to explore lifestyle factors related to AIS. METHODS: This study included 2,759 Japanese female junior high school students who planned a secondary screening after an initial moiré topography screening indicated possible scoliosis. The students and their mothers, or guardians, were asked to fill out a questionnaire consisting of 38 questions about demographic factors, lifestyle-related factors, social factors, household environment, participation in sports, health status, and factors related to the mother's pregnancy and delivery...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28192660/in-vivo-imaging-of-the-stability-and-sustained-cargo-release-of-an-injectable-amphipathic-peptide-based-hydrogel
#15
Edith Oyen, Charlotte Martin, Vicky Caveliers, Annemieke Madder, Bruno Van Mele, Richard Hoogenboom, Sophie Hernot, Steven Ballet
Hydrogels are promising materials for biomedical applications such as tissue engineering and controlled drug release. In the past two decades, the peptide hydrogel subclass has attracted an increasing level of interest from the scientific community because of its numerous advantages, such as biocompatibility, biodegradability, and, most importantly, injectability. Here, we report on a hydrogel consisting of the amphipathic hexapeptide H-FEFQFK-NH2, which has previously shown promising in vivo properties in terms of releasing morphine...
March 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28175209/no003-ibd-nurses-as-integral-part-of-a-multidisciplinary-ibd-team-prospective-study-on-view-on-patient-outcomes
#16
S Coenen, E Weyts, P Geens, S Vermeire, M Ferrante, M Noman, V Ballet, K Vanhaecht, G Van Assche
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175200/p637-anti-infliximab-antibody-concentrations-guide-therapeutic-decision-making-in-patients-with-crohn-s-disease-losing-clinical-response
#17
E Dreesen, T Van Stappen, V Ballet, S Tops, G Compernolle, G Van Assche, M Ferrante, S Vermeire, A Gils
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175117/p496-successful-dose-de-escalation-to-adalimumab-40mg-every-three-weeks-in-patients-with-crohn-s-disease
#18
M Ferrante, S Van Steenbergen, S Bian, V Ballet, S Vermeire, G Van Assche, A Gils
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172740/p686-application-of-dried-blood-spots-for-pharmacokinetic-profiling-of-golimumab-treated-patients-with-ulcerative-colitis
#19
I Detrez, V Ballet, G Van Assche, S Vermeire, M Ferrante, A Gils
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172733/dop050-serum-proteomic-analysis-defines-novel-circulating-inflammatory-markers-for-crohn-s-disease-and-response-to-anti-tnf-therapy
#20
H Korf, J Sabino, V Ballet, M de Bruyn, G Van Assche, M Ferrante, S Vermeire
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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