Read by QxMD icon Read


Júlia García-Pindado, Tom Willemse, Rebecca Goss, Bert U W Maes, Ernest Giralt, Steven Ballet, Meritxell Teixidó
While revisiting biologically active natural peptides, the importance of the tryptophan residue became clear. In this article, the incorporation of this amino acid, brominated at different positions of the indole ring, into cyclic peptides was successfully achieved. These products demonstrated improved properties in terms of passive diffusion, permeability across membranes, biostability in human serum and cytotoxicity. Moreover, these brominated tryptophans at positions 5, 6, or 7 proved to be compatible as building blocks to prepare bicyclic stapled peptides by performing on-resin Suzuki-Miyaura cross-coupling reactions...
March 12, 2018: Biopolymers
Michael A Wewege, Rachel E Ward
OBJECTIVES: To quantitatively compare bone mineral density (BMD) outcomes between pre-professional female adolescent ballet dancers and control populations. DESIGN: Systematic review and meta-analysis. METHODS: Six electronic databases and relevant journals were systematically searched up to August 2017. Included articles examined BMD in adolescent females undergoing pre-professional ballet training and healthy age-matched controls with an available English full text...
March 2, 2018: Journal of Science and Medicine in Sport
Susan Mayes, Peter Smith, Jill Cook
OBJECTIVES: Professional ballet dancers may have hip bony morphology that predisposes them to cartilage or labral injury. However, the relationship between bony morphology and pathology has not been investigated in ballet. This study investigates associations between bony morphology, chondrolabral defects and hip pain in ballet dancers. DESIGN: Cross-sectional study. METHODS: 33 male and female professional ballet dancers, (mean age 27 years (range 19-39)), completed questionnaires with hip pain measured on a visual analogue scale; and underwent 3...
March 3, 2018: Journal of Science and Medicine in Sport
Jie Bai, Xin Liu, Le Goff Laetitia, Gargala Gilles, Francois Arnaud, Ballet Jean Jacques, Ducrotte Phillipe, Favennec Loic, Liqianhai Towledahong
Somatostatins are proteins that are involved in gastrointestinal function. However, little is known with regard to somatostatin receptor subtype (SSTR) expression changes that occur in the jejunum during low-grade inflammation and during subsequent octreotide treatment. The aim of the present study was to investigate the expression of SSTRs in the jejunums of Cryptosporidium parvum (C. parvum)-infected rats by immunohistochemisty, reverse transcription (RT) PCR and quantitative real-time RT-PCR assays. Five-day-old suckling Sprague-Dawley rats (n = 15 for each group) were orally gavaged with 105 Nouzilly isolate (NoI) oocysts...
2018: PloS One
Sarah J Kenny, Luz Palacios-Derflingher, Oluwatoyosi B A Owoeye, Jackie L Whittaker, Carolyn A Emery
Critical appraisal of research investigating risk factors for musculoskeletal injury in dancers suggests high quality reliability studies are lacking. The purpose of this study was to determine between-day reliability of pre-participation screening (PPS) components in pre-professional ballet and contemporary dancers. Thirty-eight dancers (35 female, 3 male; median age; 18 years; range: 11 to 30 years) participated. Screening components (Athletic Coping Skills Inventory-28, body mass index, percent total body fat, total bone mineral density, Foot Posture Index-6, hip and ankle range of motion, three lumbopelvic control tasks, unipedal dynamic balance, and the Y-Balance Test) were conducted one week apart...
March 15, 2018: Journal of Dance Medicine & Science
Colin J Clark, Holger J Pletsch, Jason Wu, Lucas Guillemot, Matthew Kerr, Tyrel J Johnson, Fernando Camilo, David Salvetti, Bruce Allen, David Anderson, Carsten Aulbert, Christian Beer, Oliver Bock, Andres Cuéllar, Heinz-Bernd Eggenstein, Henning Fehrmann, Michael Kramer, Shawn A Kwang, Bernd Machenschalk, Lars Nieder, Markus Ackermann, Marco Ajello, Luca Baldini, Jean Ballet, Guido Barbiellini, Denis Bastieri, Ronaldo Bellazzini, Elisabetta Bissaldi, Roger D Blandford, Elliott D Bloom, Raffaella Bonino, Eugenio Bottacini, Terri J Brandt, Johan Bregeon, Philippe Bruel, Rolf Buehler, Toby H Burnett, Sara Buson, Rob A Cameron, Regina Caputo, Patrizia A Caraveo, Elisabetta Cavazzuti, Claudia Cecchi, Eric Charles, Alexandre Chekhtman, Stefano Ciprini, Lynn R Cominsky, Denise Costantin, Sara Cutini, Filippo D'Ammando, Andrea De Luca, Rachele Desiante, Leonardo Di Venere, Mattia Di Mauro, Niccolò Di Lalla, Seth W Digel, Cecilia Favuzzi, Elizabeth C Ferrara, Anna Franckowiak, Yasushi Fukazawa, Stefan Funk, Piergiorgio Fusco, Fabio Gargano, Dario Gasparrini, Nico Giglietto, Francesco Giordano, Marcello Giroletti, Germán A Gomez-Vargas, David Green, Isabelle A Grenier, Sylvain Guiriec, Alice K Harding, John W Hewitt, Deirdre Horan, Guðlaugur Jóhannesson, Shiki Kensei, Michael Kuss, Giovanni La Mura, Stefan Larsson, Luca Latronico, Jian Li, Francesco Longo, Francesco Loparco, Michael N Lovellette, Pasquale Lubrano, Jeffrey D Magill, Simone Maldera, Alberto Manfreda, Mario N Mazziotta, Julie E McEnery, Peter F Michelson, Nestor Mirabal, Warit Mitthumsiri, Tsunefumi Mizuno, Maria Elena Monzani, Aldo Morselli, Igor V Moskalenko, Eric Nuss, Takashi Ohsugi, Nicola Omodei, Monica Orienti, Elena Orlando, Michele Palatiello, Vaidehi S Paliya, Francesco de Palma, David Paneque, Jeremy S Perkins, Massimo Persic, Melissa Pesce-Rollins, Troy A Porter, Giacomo Principe, Silvia Rainò, Riccardo Rando, Paul S Ray, Massimiliano Razzano, Anita Reimer, Olaf Reimer, Roger W Romani, Pablo M Saz Parkinson, Carmelo Sgrò, Eric J Siskind, David A Smith, Francesca Spada, Gloria Spandre, Paolo Spinelli, Jana B Thayer, David J Thompson, Diego F Torres, Eleonora Troja, Giacomo Vianello, Kent Wood, Matthew Wood
Millisecond pulsars (MSPs) are old neutron stars that spin hundreds of times per second and appear to pulsate as their emission beams cross our line of sight. To date, radio pulsations have been detected from all rotation-powered MSPs. In an attempt to discover radio-quiet gamma-ray MSPs, we used the aggregated power from the computers of tens of thousands of volunteers participating in the Einstein@Home distributed computing project to search for pulsations from unidentified gamma-ray sources in Fermi Large Area Telescope data...
February 2018: Science Advances
Sarah L Carter, Rebekha Duncan, Andries L Weidemann, Luke S Hopper
Turnout is a central element of classical ballet which involves sustained external rotation of the lower limbs during dance movements. Lower leg and foot compensation mechanisms which are often used to increase turnout have been attributed to the high incidence of lower limb injury in dancers. Evaluation of dancers' leg posture is needed to provide insight into the lower limb kinematic strategies used to achieve turnout. The primary purpose of this study was to use 3D kinematic analyses to determine the lower leg and foot compensations that are incorporated by female university dancers to accentuate their turnout...
March 2, 2018: Journal of Sports Sciences
Florian Barthélémy, Aurélia Defour, Nicolas Lévy, Martin Krahn, Marc Bartoli
Skeletal muscle undergoes many micro-membrane lesions at physiological state. Based on their sizes and magnitude these lesions are repaired via different complexes on a specific spatio-temporal manner. One of the major repair complex is a dysferlin-dependent mechanism. Accordingly, mutations in the DYSF gene encoding dysferlin results in the development of several muscle pathologies called dysferlinopathies, where abnormalities of the membrane repair process have been characterized in patients and animal models...
2018: Journal of Neuromuscular Diseases
Ana García Dantas, Diana Amado Alonso, Pedro Antonio Sánchez-Miguel, Carmen Del Río Sánchez
Body dissatisfaction constitutes an important factor in the development of eating pathologies, particularly among dancers. The aim of this research was to test the factors that dancers identified as relevant to their body dissatisfaction using an exploratory mixed method design. Participants were 369 dancers from two Spanish dance conservatories. Questionnaires assessed body dissatisfaction, abnormal eating attitudes and behaviors, and risk factors to eating disorders in the dance domain. Nine factors were found; the "teacher", the "uniform", and the "mirrors" were the most common...
February 20, 2018: Body Image
Els Pardon, Cecilia Betti, Toon Laeremans, Florent Chevillard, Karel Guillemyn, Peter Kolb, Steven Ballet, Jan Steyaert
The conformational complexity of G protein-coupled receptor (GPCR) transmembrane signaling is a central hurdle for the design of screens for receptor agonists. In their basal states, GPCRs have lower affinities for agonists compared to their G protein-bound active state conformations. Moreover, different agonists can stabilize distinct active receptor conformations and do not uniformly activate all cellular signaling pathways linked to a given receptor (agonist bias). Herein, comparative fragment screens were performed on a β2 adrenoreceptor-Nanobody fusion locked in its active state conformation by a G protein mimicking Nanobody, and the same receptor in its basal state conformation...
February 22, 2018: Angewandte Chemie
Josianne Rodrigues-Krause, Mauricio Krause, Alvaro Reischak-Oliveira
Context • Dancing has been used as a form of exercise to improve functional and metabolic outcomes during aging. The field lacks randomized, clinical trials (RCTs) evaluating metabolic outcomes related to dance interventions, but dancing may be a form of exercise that could induce positive effects on the metabolic health of older adults. However, primary studies seem very heterogonous regarding the trial designs, characteristics of the interventions, the methods for outcomes assessments, statistical powers, and methodological quality...
February 10, 2018: Alternative Therapies in Health and Medicine
Sarah Staal, Anders Sjödin, Ida Fahrenholtz, Karen Bonnesen, Anna Melin
Ballet dancers are reported to have an increased risk for energy deficiency with or without disordered eating (DE) behavior. A low ratio between measured (m) and predicted (p) resting metabolic rate (RMRratio<0.90) is a recognized surrogate marker for energy deficiency. We aimed to evaluate the prevalence of suppressed RMR using different methods to calculate pRMR and to explore associations with additional markers of energy deficiency. Female (n=20) and male (n=20) professional ballet dancers, 19-35 years of age were enrolled...
February 6, 2018: International Journal of Sport Nutrition and Exercise Metabolism
Akinobu Nishimura, Shigeto Nakazora, Naoya Ito, Aki Fukuda, Ko Kato, Akihiro Sudo
Longitudinal flexor hallucis longus (FHL) tendon tears are sometimes complicated by posterior ankle impingement syndrome (PAIS), especially in ballet dancers. In recent years, PAIS has been treated endoscopically, but it is difficult to suture FHL tendon tears endoscopically. In this report, we describe how to suture the FHL tendon endoscopically with the Meniscal Viper Repair system (Arthrex, Naples, FL). Without our endoscopic technique, when a patient is found to have a longitudinal tear of the FHL under endoscopy, we must choose to either neglect the tear or convert to an open repair...
October 2017: Arthroscopy Techniques
E Gabrielli, E Pericolini, N Ballet, E Roselletti, S Sabbatini, P Mosci, A Cayzeele Decherf, F Pélerin, S Perito, P Jüsten, A Vecchiarelli
Previously we demonstrated that the treatment with live Saccharomyces cerevisiae exerts beneficial therapeutic effects against vaginal candidiasis. Here, we address potential mechanisms particularly examining the probiotic capacity to modulate both fungus and host-related factors. We show that the S. cerevisiae-based probiotic markedly affects the expression of virulence traits of Candida albicans such as aspartyl proteinases (SAPs) as well as hyphae-associated proteins Hwp1 and Ece1 in the vaginal cavity. On the host side, the probiotic suppression of the influx of neutrophils caused by the fungus into the vaginas of the mice is likely related to: (1) lower production of interleukin-8; and (2) inhibition of SAPs expression...
January 30, 2018: Beneficial Microbes
O Van der Poorten, R Van Den Hauwe, K Hollanders, B U W Maes, D Tourwé, M Jida, S Ballet
A 3-step methodology for the synthesis of 1,5-benzothiazepin-4(5H)-one dipeptidomimetics has been elaborated via an Ugi-4CR followed by a S-trityl deprotection and an intramolecular Cu(i)-catalyzed Ullmann condensation with moderate to good yields. In silico and NMR conformational studies showed that the lowest energy conformers stabilize γ- and β-turn structures.
January 30, 2018: Organic & Biomolecular Chemistry
Olivier Van der Poorten, Baptiste Legrand, Lubomir Vezenkov, Julia Garcia-Pindado, Nadir Bettache, Astrid Knuhtsen, Daniel Sejer Pedersen, Macarena Sanchez-Navarro, Jean Martinez, Meritxell Teixido, Marcel Garcia, Dirk Tourwe, Muriel Amblard, Steven Ballet
Non-cationic and amphipathic indoloazepinone-constrained (Aia) oligomers have been synthesized as new vectors for intracellular delivery. The conformational preferences of the [L-Aia-Xxx]n oligomers were investigated using circular dichroism and NMR spectroscopy. While Boc-[L-Aia-Gly]2,4-OBn 12-13 and Boc-[L-Aia-β3-h-L-Ala]2,4-OBn 16-17 oligomers were totally or partially disordered, Boc-[L-Aia-L-Ala]2-OBn 14 induced a typical turn stabilized by C5- and C7-membered H-bond pseudo-cycles and aromatic interactions...
January 29, 2018: Chembiochem: a European Journal of Chemical Biology
Florent Chevillard, Helena Rimmer, Cecilia Betti, Els Pardon, Steven Ballet, Niek van Hilten, Jan Steyaert, Wibke E Diederich, Peter Kolb
Fragment-based drug discovery is intimately linked to fragment extension approaches that can be accelerated using software for de novo design. Although computers allow for the facile generation of millions of suggestions, synthetic feasibility is however often neglected. In this study we computationally extended, chemically synthesized, and experimentally assayed new ligands for the β2-adrenergic receptor (β2AR) by growing fragment-sized ligands. In order to address the synthetic tractability issue, our in silico workflow aims at derivatized products based on robust organic reactions...
January 24, 2018: Journal of Medicinal Chemistry
An De Prins, Charlotte Martin, Yannick Van Wanseele, Louise Julie Skov, Csaba Tömböly, Dirk Tourwé, Vicky Caveliers, Ann Van Eeckhaut, Birgitte Holst, Mette Marie Rosenkilde, Ilse Smolders, Steven Ballet
Neuromedin U (NMU) is a highly conserved endogenous peptide that is involved in a wide range of physiological processes such as regulation of feeding behavior, the stress response and nociception. The major limitation to use NMU as a therapeutic is its short half-life. Here, we describe the development of a set of novel NMU-analogs based on NMU-8, by introducing unnatural amino acids into the native sequence. This approach shows that it is possible to generate molecules with increased potency and improved plasma stability without major changes of the peptidic nature or the introduction of large conjugates...
December 14, 2017: European Journal of Medicinal Chemistry
Shaw Bronner, Caroline McBride, Allison Gill
We analysed work-related musculoskeletal injuries (WMSI) in two modern dance companies to determine whether injury rates decreased and patterns altered compared to previous 3-yr and 6-yr audits (0.48 and 0.25/1000-hrs exposure respectively). In this prospectively designed 15-yr cohort study, data were collected in 30-dancer Company-1 and 12-dancer Company-2. In-house physical therapists tracked WMSI and time-loss-injuries for 159 dancers (42 dancers/yr). 15-yrs were grouped into five 3-yr blocks for comparison with prior audits...
January 10, 2018: Journal of Sports Sciences
Jessica Biernacki, Andrea Stracciolini, Kelsey Griffith, Pierre d'Hemecourt, Michael Owen, Dai Sugimoto
OBJECTIVES: The purpose of this study was to investigate the relationship between coping skills and current hip pain and function scores in ballet dancers. Secondly, we examined the relationship between coping skills and past injuries. Thirdly, we investigated the association between past injuries and current pain and function scores. METHODS: This was a cross-sectional observational study. Twenty-six young elite female dancers (mean age 15.9 years, range 14-17 years) participated...
January 5, 2018: Physician and Sportsmedicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"