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https://www.readbyqxmd.com/read/29329072/development-of-potent-and-proteolytically-stable-human-neuromedin-u-receptor-agonists
#1
An De Prins, Charlotte Martin, Yannick Van Wanseele, Louise Julie Skov, Csaba Tömböly, Dirk Tourwé, Vicky Caveliers, Ann Van Eeckhaut, Birgitte Holst, Mette Marie Rosenkilde, Ilse Smolders, Steven Ballet
Neuromedin U (NMU) is a highly conserved endogenous peptide that is involved in a wide range of physiological processes such as regulation of feeding behavior, the stress response and nociception. The major limitation to use NMU as a therapeutic is its short half-life. Here, we describe the development of a set of novel NMU-analogs based on NMU-8, by introducing unnatural amino acids into the native sequence. This approach shows that it is possible to generate molecules with increased potency and improved plasma stability without major changes of the peptidic nature or the introduction of large conjugates...
December 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29320307/musculoskeletal-injuries-in-professional-modern-dancers-a-prospective-cohort-study-of-15-years
#2
Shaw Bronner, Caroline McBride, Allison Gill
We analysed work-related musculoskeletal injuries (WMSI) in two modern dance companies to determine whether injury rates decreased and patterns altered compared to previous 3-yr and 6-yr audits (0.48 and 0.25/1000-hrs exposure respectively). In this prospectively designed 15-yr cohort study, data were collected in 30-dancer Company-1 and 12-dancer Company-2. In-house physical therapists tracked WMSI and time-loss-injuries for 159 dancers (42 dancers/yr). 15-yrs were grouped into five 3-yr blocks for comparison with prior audits...
January 10, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29301454/association-between-coping-skills-past-injury-and-hip-pain-and-function-in-adolescent-elite-female-ballet-dancers
#3
Jessica Biernacki, Andrea Stracciolini, Kelsey Griffith, Pierre d'Hemecourt, Michael Owen, Dai Sugimoto
OBJECTIVES: The purpose of this study was to investigate the relationship between coping skills and current hip pain and function scores in ballet dancers. Secondly, we examined the relationship between coping skills and past injuries. Thirdly, we investigated the association between past injuries and current pain and function scores. METHODS: This was a cross-sectional observational study. Twenty-six young elite female dancers (mean age 15.9 years, range 14-17 years) participated...
January 5, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29289495/mechanism-of-action-pharmacokinetics-efficacy-and-safety-of-transarterial-therapies-using-ethiodized-oil-preclinical-review-in-liver-cancer-models
#4
Ron C Gaba, Regina M Schwind, Sebastien Ballet
PURPOSE: To systematically review mechanism of action, pharmacokinetics (PKs), efficacy, and safety of ethiodized oil-based locoregional therapy (LRT) for liver cancer in preclinical models. MATERIALS AND METHODS: A MEDLINE search was performed from 1988 to 2016. Search terms included hepatocellular carcinoma (HCC), HCC, liver-cell carcinoma, liver, hepatic, hepatocarcinoma, transarterial or chemoembolization, TACE, animal, Lipiodol, Ethiodol, iodized oil, and/or poppy-seed oil...
December 28, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29284180/study-of-top-ballet-school-students-revealed-large-deficiencies-in-their-body-weight-and-body-fat
#5
Elżbieta Grochowska-Niedworok, Marek Kardas, Edyta Fatyga, Karolina Piórkowska-Staniek, Małgorzata Muc-Wierzgoń, Teresa Kokot
AIM: This study assessed the nutritional status and physical activity levels of 150 female students aged 10-18 from three top Polish ballet schools, where the most promising dancers go on to pursue professional ballet careers. METHODS: We analysed the girls' body composition, physical activity level (PAL) and PAL coefficient. The ballet students also completed a questionnaire. RESULTS: The results revealed large deficiencies in the body weight and body fat of the young ballerinas...
December 28, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29250342/hip-dysplasia-in-wrestlers-three-lessons-learned
#6
J W Thomas Byrd, John C Clohisy, Young-Jo Kim, F Winston Gwathmey, Kay S Jones, Michael B Millis
Hip problems due to dysplasia are commonly associated with female athletes in sports demanding supraphysiologic motion, such as ballet, gymnastics and figure skating. However, hip problems are rarely mentioned among wrestlers, a male sport in which flexibility is advantageous. Dysplasia may have a mostly unrecognized prevalence among wrestlers that can lead to problems and benefit from reorientation periacetabular osteotomy (PAO). Study design in this research is Level 4 evidence case reports. Three consecutive intercollegiate wrestlers ages 20, 21 and 22 years underwent PAO for dysplasia and are reported...
December 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29237356/the-influence-of-injury-definition-on-injury-burden-in-pre-professional-ballet-and-contemporary-dancers
#7
Sarah J Kenny, Luz Palacios-Derflingher, Jackie L Whittaker, Carolyn A Emery
Study Design Cohort study. Background Multiple operational definitions of injury exist in dance research. The influence that these different injury definitions have on epidemiological estimations of injury burden among dancers warrants investigation. Objective To describe the influence of injury definition on injury prevalence, incidence, and severity in pre-professional ballet and contemporary dancers. Methods Dancers registered in full-time pre-professional ballet [n=85, 77 females, median age 15-years (range 11-19)] and contemporary [n=60, 58 females, median age 19-years (range 17-30)] training completed weekly online questionnaires (modified Oslo Sports Trauma Research Centre's Questionnaire on Health Problems) using three injury definitions: (1) time-loss (unable to complete ≥1 class/rehearsal/performance ≥1 day(s) beyond onset); (2) medical attention; (3) any complaint...
December 13, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29226370/anti-infliximab-antibody-concentrations-can-guide-on-treatment-intensification-in-patients-with-crohn-s-disease-who-lose-clinical-response
#8
E Dreesen, T Van Stappen, V Ballet, M Peeters, G Compernolle, S Tops, K Van Steen, G Van Assche, M Ferrante, S Vermeire, A Gils
BACKGROUND: The presence of antibodies towards infliximab (ATI) is associated with lower infliximab (IFX) trough concentrations and loss of response. IFX treatment intensification is effective for restoring response in most, but not all patients with Crohn's disease (CD). AIM: To compare outcome, pharmacokinetics and immunogenicity of treatment intensification strategies in patients with CD who lost clinical response to IFX. METHODS: A retrospective cohort study was conducted, including 103 patients with CD who lost clinical response during IFX maintenance therapy and therefore received a double dose IFX (10 mg/kg) and/or a next infusion after a shortened interval...
December 11, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29193977/comment-on-in-vivo-drug-delivery-performance-of-lipiodol-based-emulsion-or-drug-eluting-beads-in-patients-with-hepatocellular-carcinoma
#9
Walter González, Jean-Marc Idée, Sebastien Ballet
No abstract text is available yet for this article.
December 1, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29192540/thoracoabdominal-breathing-motion-pattern-and-coordination-of-professional-ballet-dancers
#10
Isabella Martins Rodrigues, Gustavo Ramos Dalla Bernardina, Karine Jacon Sarro, Guido Baroni, Pietro Cerveri, Amanda Piaia Silvatti
Ballet training includes exercises of high and moderate intensities, which require breathing control for a good performance. This study describes the thoracoabdominal motion of professional dancers and compares the breathing patterns between professional dancers and non-dancers. Participants of this study were four male and four female (30.33 ± 4.64 years) professional dancers and four male and four female (22.75 ± 1.49 years) non-dancers. The participants executed two breathing manoeuvres while sitting motionless: quiet breathing (QB) and vital capacity (VC)...
December 1, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/29166988/external-focus-of-attention-enhances-children-s-learning-of-a-classical-ballet-pirouette
#11
Mariana Teixeira da Silva, Helena Thofehrn Lessa, Suzete Chiviacowsky
The purpose of the present study was to investigate the influence of instructions promoting an external versus internal focus of attention on the learning of a specific balance task, the pirouette en dehors (from fourth position), in 10-year-old novice ballet students. In addition, we sought to gain insight into learners' motivation and subjective learning experience as a function of different focus conditions. Thirty-eight children were randomly assigned to one of two groups. In the external focus (EF) group, participants were asked to focus on a spotting point on the wall in front of them for as long as possible...
December 15, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/29166985/postural-control-during-different-unipodal-positions-in-professional-ballet-dancers
#12
Michelle Costa de Mello, Arthur de Sá Ferreira, Lilian Ramiro Felicio
Classical ballet involves the performance of complex movements that require high-level motor skills and good postural control. This study explored postural sway in passé en demi-pointe position in dancers and compared single-leg standing sway (with and without visual restriction) between dancers and non-dancers. Fourteen professional dancers and 14 sex- and age-matched volunteers who were not ballet dancers participated in the study. Participants stood on a force plate on the dominant leg in the following positions: 1...
December 15, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/29166983/comparison-study-of-body-image-satisfaction-between-beginning-and-advanced-level-female-ballet-students
#13
Sally A Radell, Margaret L Keneman, Mara P Mandradjieff, Daniel D Adame, Steven P Cole
This mixed methods study compares the level of satisfaction with one's body image between beginning- and advanced-level female collegiate ballet students. Thirty-six beginning-level students were enrolled in two ballet classes, and a second group of 16 advanced-level students was enrolled in a third class. A mirror was used in the teaching of both groups. During the first and thirteenth week of a 14-week semester, students completed the Cash 69-item Body Self-Relations Questionnaire. In addition, five students from each group were randomly selected to participate in semi-structured interviews during the second and last week of the semester...
December 15, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/29152051/%C3%AF-space-screening-of-dermorphin-based-tetrapeptides-through-use-of-constrained-arylazepinone-and-quinolinone-scaffolds
#14
Olivier Van der Poorten, Robin Van Den Hauwe, Emilie Eiselt, Cecilia Betti, Karel Guillemyn, Nga N Chung, François Hallé, Frédéric Bihel, Peter W Schiller, Dirk Tourwé, Philippe Sarret, Louis Gendron, Steven Ballet
Herein, the synthesis of novel conformationally constrained amino acids, 4-amino-8-bromo-2-benzazepin-3-one (8-Br-Aba), 3-amino-3,4-dihydroquinolin-2-one, and regioisomeric 4-amino-naphthoazepinones (1- and 2-Ana), is described. Introduction of these constricted scaffolds into the N-terminal tetrapeptide of dermorphin (i.e., H-Tyr-d-Ala-Phe-Gly-NH2) induced significant shifts in binding affinity, selectivity, and in vitro activity at the μ- and δ-opioid receptors (MOP and DOP, respectively). A reported constrained μ-/δ-opioid lead tetrapeptide H-Dmt-d-Arg-Aba-Gly-NH2 was modified through application of various constrained building blocks to identify optimal spatial orientations in view of activity at the opioid receptors...
November 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29147730/on-the-skilled-plantar-flexor-motor-action-and-unique-electromyographic-activity-of-ballet-dancers
#15
Sakiko Saito, Hiroki Obata, Mayumi Kuno-Mizumura, Kimitaka Nakazawa
The study aimed to compare the ability of dance and non-dance subjects to perform fine control of a simple heel-raising/lowering movement, and to determine if there are any differences in motor unit activity in the primary plantar flexor muscles during the movement. Subjects were instructed to accurately track a sinusoidal trace with a heel-raising and lowering movement at four controlled frequencies (1, 0.5, 0.25, and 0.125 Hz). The ankle joint angle was used to characterize movement errors from the target...
November 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29138448/antimicrobial-peptides-in-frog-poisons-constitute-a-molecular-toxin-delivery-system-against-predators
#16
Constantijn Raaymakers, Elin Verbrugghe, Sophie Hernot, Tom Hellebuyck, Cecilia Betti, Cindy Peleman, Myriam Claeys, Wim Bert, Vicky Caveliers, Steven Ballet, An Martel, Frank Pasmans, Kim Roelants
Animals using toxic peptides and proteins for predation or defense typically depend on specialized morphological structures, like fangs, spines, or a stinger, for effective intoxication. Here we show that amphibian poisons instead incorporate their own molecular system for toxin delivery to attacking predators. Skin-secreted peptides, generally considered part of the amphibian immune system, permeabilize oral epithelial tissue and enable fast access of cosecreted toxins to the predator's bloodstream and organs...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29116433/safety-of-everolimus-plus-exemestane-in-patients-with-hormone-receptor-positive-her2-negative-locally-advanced-or-metastatic-breast-cancer-results-of-phase-iiib-ballet-trial-in-spain
#17
E Ciruelos, M Vidal, E Martínez de Dueñas, N Martínez-Jáñez, Y Fernández, J A García-Sáenz, L Murillo, F Carabantes, A Beliera, R Fonseca, J Gavilá
BACKGROUND: Everolimus with exemestane has shown promising activity in patients with hormone-receptor (HR)-positive HER2-negative endocrine-resistant advanced breast cancer. It is necessary, therefore, to characterize the safety profile of this new combination in the real-world clinical setting and in the broadest possible population. PATIENTS AND METHODS: Post-menopausal women with HR-positive HER2-negative advanced breast cancer progressing after prior non-steroidal aromatase inhibitors (NSAIs) were included...
November 7, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29112056/effects-of-a-resistance-training-intervention-on-strength-power-and-performance-in-adolescent-dancers
#18
Rebecca A Dowse, Mike R McGuigan, Craig Harrison
Dowse, RA, McGuigan, MR, and Harrison, C. Effects of a resistance training intervention on strength, power, and performance in adolescent dancers. J Strength Cond Res XX(X): 000-000, 2017-The aim of this study was to determine whether a 9-week resistance training program could have a significant effect on maximum lower-body strength and power, dynamic balance, and dance performance in adolescent dancers. Twelve competitive adolescent female dancers trained in jazz, ballet, and contemporary were recruited from local dance schools and assigned to a resistance training group (dance experience 9...
November 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29106341/the-long-term-impact-of-an-eating-disorder-prevention-program-for-professional-ballet-school-students-a-15-year-follow-up-study
#19
Rachel J Bar, Stephanie E Cassin, Michelle M Dionne
Eating disorder prevention programs have been assessed up to 3 years post-implementation; however, their impact on long-term resilience is unclear. The current study assessed disordered eating and body dissatisfaction in 116 dancers from a professional ballet school 15 or more years following their participation in an effective selective prevention program. Dancers who attended the ballet school during and following the program endorsed fewer thoughts and behaviours associated with bulimia, had lower lifetime prevalence of laxative use, and showed a trend toward lower lifetime rates of vomiting to control weight than those who attended the ballet school prior to the intervention...
October 2017: Eating Disorders
https://www.readbyqxmd.com/read/29106340/on-synchronicity-passing-the-torch-and-the-task-of-prevention
#20
Niva Piran
The 15-year follow-up study (Bar, Chassin & Dionne, 2017) suggests of the Dance School Ecological Prevention Program (Piran, 1999) that it may have had long-term effects on the prevention of bulimia. This pattern of findings is in line with the results of the older cohort in the original outcome evaluation study. If the results of the follow up study hold when the 15-year outcome evaluation study is compared to a control group from a similarly competitive ballet school, this would reinforce the cause of prevention in the field of sports and dance, if not beyond...
October 2017: Eating Disorders
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